ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	8.94606325
2	DNA methylation involved in gamete generation (GO:0043046)	8.88551768
3	lipopolysaccharide biosynthetic process (GO:0009103)	8.47285859
4	protein-chromophore linkage (GO:0018298)	8.45765647
5	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.70818160
6	regulation of meiosis I (GO:0060631)	7.63242379
7	lipopolysaccharide metabolic process (GO:0008653)	7.38217373
8	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.06342082
9	regulation of protein glycosylation (GO:0060049)	6.93248112
10	sulfate transmembrane transport (GO:1902358)	6.92304048
11	regulation of pigment cell differentiation (GO:0050932)	6.81096426
12	positive regulation of developmental pigmentation (GO:0048087)	6.77104189
13	piRNA metabolic process (GO:0034587)	6.72341325
14	paraxial mesoderm development (GO:0048339)	6.28116565
15	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	6.26730651
16	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.24384690
17	sulfate transport (GO:0008272)	5.83715237
18	negative regulation of glycoprotein metabolic process (GO:1903019)	5.70844304
19	tachykinin receptor signaling pathway (GO:0007217)	5.65711948
20	L-phenylalanine catabolic process (GO:0006559)	5.42918261
21	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.42918261
22	ribonucleoprotein complex disassembly (GO:0032988)	5.34565495
23	heme transport (GO:0015886)	5.29859543
24	notochord development (GO:0030903)	4.99537795
25	tyrosine metabolic process (GO:0006570)	4.98146058
26	SMAD protein complex assembly (GO:0007183)	4.88817349
27	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.70352190
28	organelle disassembly (GO:1903008)	4.65795143
29	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.54040181
30	L-phenylalanine metabolic process (GO:0006558)	4.54040181
31	positive regulation of meiosis (GO:0045836)	4.40599914
32	negative regulation of stem cell proliferation (GO:2000647)	4.30660633
33	serotonin receptor signaling pathway (GO:0007210)	4.28684208
34	vitamin transmembrane transport (GO:0035461)	4.24262673
35	centriole replication (GO:0007099)	4.23620171
36	regulation of odontogenesis (GO:0042481)	4.17351572
37	positive regulation of meiotic cell cycle (GO:0051446)	4.08674991
38	meiotic chromosome segregation (GO:0045132)	4.08219107
39	glycerol metabolic process (GO:0006071)	4.01223291
40	regulation of interleukin-5 production (GO:0032674)	3.93359086
41	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.93256458
42	nodal signaling pathway (GO:0038092)	3.88863742
43	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.88652938
44	regulation of hair follicle development (GO:0051797)	3.83764376
45	regulation of transforming growth factor beta2 production (GO:0032909)	3.82933344
46	DNA damage induced protein phosphorylation (GO:0006975)	3.81822080
47	iron coordination entity transport (GO:1901678)	3.73231744
48	germinal center formation (GO:0002467)	3.69997789
49	response to mercury ion (GO:0046689)	3.68850881
50	aromatic amino acid family catabolic process (GO:0009074)	3.64738764
51	rhodopsin mediated signaling pathway (GO:0016056)	3.64661775
52	alditol metabolic process (GO:0019400)	3.60718947
53	flavonoid metabolic process (GO:0009812)	3.57560282
54	embryonic process involved in female pregnancy (GO:0060136)	3.55439941
55	pantothenate metabolic process (GO:0015939)	3.55400777
56	sympathetic nervous system development (GO:0048485)	3.52667640
57	sulfur compound transport (GO:0072348)	3.50780475
58	regulation of gonadotropin secretion (GO:0032276)	3.50447652
59	regulation of developmental pigmentation (GO:0048070)	3.36360593
60	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.35229313
61	negative regulation of neural precursor cell proliferation (GO:2000178)	3.30371999
62	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.26694815
63	inflammatory response to antigenic stimulus (GO:0002437)	3.25342216
64	aspartate family amino acid catabolic process (GO:0009068)	3.25249245
65	toxin metabolic process (GO:0009404)	3.23289114
66	cellular response to gamma radiation (GO:0071480)	3.23109055
67	protein retention in ER lumen (GO:0006621)	3.22561083
68	urate metabolic process (GO:0046415)	3.18739882
69	response to epinephrine (GO:0071871)	3.18179390
70	aromatic amino acid family metabolic process (GO:0009072)	3.15992619
71	DNA methylation (GO:0006306)	3.12626264
72	DNA alkylation (GO:0006305)	3.12626264
73	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.11832412
74	regulation of translational termination (GO:0006449)	3.07844518
75	heart valve formation (GO:0003188)	3.02357380
76	negative regulation of cell-matrix adhesion (GO:0001953)	3.00460547
77	regulation of keratinocyte proliferation (GO:0010837)	2.99401523
78	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.97427580
79	somite rostral/caudal axis specification (GO:0032525)	2.95887642
80	dicarboxylic acid catabolic process (GO:0043649)	2.92673451
81	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.90921795
82	uterus development (GO:0060065)	2.90482521
83	DNA deamination (GO:0045006)	2.90365860
84	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.89612912
85	organic cation transport (GO:0015695)	2.85640139
86	positive regulation of fatty acid oxidation (GO:0046321)	2.85605332
87	cofactor transport (GO:0051181)	2.82919396
88	polyol biosynthetic process (GO:0046173)	2.78527857
89	lysine metabolic process (GO:0006553)	2.77110945
90	lysine catabolic process (GO:0006554)	2.77110945
91	membrane lipid biosynthetic process (GO:0046467)	2.75348593
92	regulation of hair cycle (GO:0042634)	2.70917967
93	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.70643501
94	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.69135654
95	centriole assembly (GO:0098534)	2.68853293
96	organ induction (GO:0001759)	2.68849484
97	adaptation of signaling pathway (GO:0023058)	2.68808850
98	sphingosine metabolic process (GO:0006670)	16.3352988
99	diol metabolic process (GO:0034311)	14.9467589
100	sphingoid metabolic process (GO:0046519)	13.3463984

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	4.75131627
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.59053198
3	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.25482232
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.24048898
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.11834762
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.01759462
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.74150725
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.72262630
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.59722039
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55081090
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43557028
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.25773683
13	P300_19829295_ChIP-Seq_ESCs_Human	2.25499937
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.09117121
15	EGR1_19032775_ChIP-ChIP_M12_Human	2.00822944
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.94270915
17	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.92159429
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89880691
19	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.89572298
20	NANOG_19829295_ChIP-Seq_ESCs_Human	1.88349041
21	SOX2_19829295_ChIP-Seq_ESCs_Human	1.88349041
22	VDR_22108803_ChIP-Seq_LS180_Human	1.81641790
23	HOXB7_26014856_ChIP-Seq_BT474_Human	1.76303561
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.74741540
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.70099337
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67294596
27	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.65587105
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59460461
29	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.59392003
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55307555
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55307555
32	TCF4_23295773_ChIP-Seq_U87_Human	1.52759986
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.52611923
34	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.51400942
35	STAT1_20625510_ChIP-Seq_HELA_Human	1.50038072
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49978519
37	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.46241765
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44683996
39	AR_25329375_ChIP-Seq_VCAP_Human	1.44469139
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42744234
41	STAT3_23295773_ChIP-Seq_U87_Human	1.42437668
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39246072
43	OCT4_20526341_ChIP-Seq_ESCs_Human	1.39077085
44	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.37018018
45	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.34139215
46	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.33345222
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.32854018
48	NCOR_22424771_ChIP-Seq_293T_Human	1.31335183
49	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.27375331
50	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.27323913
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26905313
52	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.26878462
53	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.26002983
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25467543
55	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.25245228
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20834508
57	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.19003335
58	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16677001
59	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.16519717
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16338729
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.13775975
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12992695
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12992695
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12849518
65	AR_19668381_ChIP-Seq_PC3_Human	1.12337889
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12249640
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11750154
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11210191
69	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.10852982
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10764977
71	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.10690044
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.10549733
73	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.09969463
74	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.08987601
75	CDX2_22108803_ChIP-Seq_LS180_Human	1.05998935
76	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04501749
77	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.04464393
78	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04454823
79	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.03891061
80	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.02729982
81	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.01910999
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01869534
83	CEBPB_22108803_ChIP-Seq_LS180_Human	1.01207736
84	CBP_20019798_ChIP-Seq_JUKART_Human	1.00983356
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00983356
86	STAT1_17558387_ChIP-Seq_HELA_Human	1.00503946
87	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00289391
88	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00126007
89	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00000862
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.99802408
91	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.97225807
92	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.96553722
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96390043
94	GATA3_26560356_Chip-Seq_TH1_Human	0.96275020
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96011967
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95967873
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.95423776
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94463859
99	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.94451871
100	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93425392

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.37340422
2	MP0003136_yellow_coat_color	7.71301475
3	MP0005171_absent_coat_pigmentation	7.34361987
4	MP0002653_abnormal_ependyma_morphology	5.81652807
5	MP0003045_fibrosis	4.60080090
6	MP0003646_muscle_fatigue	4.32093913
7	MP0003890_abnormal_embryonic-extraembry	3.95337654
8	MP0003879_abnormal_hair_cell	3.06792592
9	MP0004381_abnormal_hair_follicle	3.02567191
10	MP0000569_abnormal_digit_pigmentation	2.83083414
11	MP0002138_abnormal_hepatobiliary_system	2.43099314
12	MP0004147_increased_porphyrin_level	2.30705140
13	MP0005085_abnormal_gallbladder_physiolo	2.29800748
14	MP0005075_abnormal_melanosome_morpholog	2.22370455
15	MP0005670_abnormal_white_adipose	2.13808137
16	MP0000749_muscle_degeneration	2.08556818
17	MP0002938_white_spotting	1.91202963
18	MP0002168_other_aberrant_phenotype	1.86850604
19	MP0005365_abnormal_bile_salt	1.72041297
20	MP0003195_calcinosis	1.57198715
21	MP0003705_abnormal_hypodermis_morpholog	1.35873497
22	MP0002095_abnormal_skin_pigmentation	1.29171475
23	MP0010352_gastrointestinal_tract_polyps	1.29106616
24	MP0002075_abnormal_coat/hair_pigmentati	1.21994339
25	MP0001501_abnormal_sleep_pattern	1.20738636
26	MP0002160_abnormal_reproductive_system	1.16222493
27	MP0005395_other_phenotype	1.15395456
28	MP0003137_abnormal_impulse_conducting	1.10760884
29	MP0003252_abnormal_bile_duct	1.09849485
30	MP0001984_abnormal_olfaction	1.06432452
31	MP0004233_abnormal_muscle_weight	1.06145936
32	MP0003300_gastrointestinal_ulcer	0.91846967
33	MP0001186_pigmentation_phenotype	0.90377735
34	MP0005174_abnormal_tail_pigmentation	0.90163812
35	MP0005330_cardiomyopathy	0.88452662
36	MP0002735_abnormal_chemical_nociception	0.84303564
37	MP0002269_muscular_atrophy	0.82483241
38	MP0002102_abnormal_ear_morphology	0.79832937
39	MP0003950_abnormal_plasma_membrane	0.74570324
40	MP0004043_abnormal_pH_regulation	0.73372799
41	MP0001324_abnormal_eye_pigmentation	0.70857999
42	MP0000534_abnormal_ureter_morphology	0.69827795
43	MP0005319_abnormal_enzyme/_coenzyme	0.69169973
44	MP0005389_reproductive_system_phenotype	0.68211240
45	MP0002272_abnormal_nervous_system	0.65235895
46	MP0000427_abnormal_hair_cycle	0.65043364
47	MP0002277_abnormal_respiratory_mucosa	0.63496323
48	MP0006054_spinal_hemorrhage	0.63320002
49	MP0002254_reproductive_system_inflammat	0.62340650
50	MP0002928_abnormal_bile_duct	0.59175949
51	MP0009745_abnormal_behavioral_response	0.57444881
52	MP0001486_abnormal_startle_reflex	0.57091202
53	MP0000015_abnormal_ear_pigmentation	0.56061656
54	MP0002163_abnormal_gland_morphology	0.56058114
55	MP0005551_abnormal_eye_electrophysiolog	0.53433291
56	MP0003937_abnormal_limbs/digits/tail_de	0.53037267
57	MP0008569_lethality_at_weaning	0.52813482
58	MP0002876_abnormal_thyroid_physiology	0.52314955
59	MP0002332_abnormal_exercise_endurance	0.50916131
60	MP0001970_abnormal_pain_threshold	0.49870738
61	MP0001800_abnormal_humoral_immune	0.49436340
62	MP0005410_abnormal_fertilization	0.48978563
63	MP0003880_abnormal_central_pattern	0.48621418
64	MP0009764_decreased_sensitivity_to	0.48525321
65	MP0003283_abnormal_digestive_organ	0.47917398
66	MP0005646_abnormal_pituitary_gland	0.47341979
67	MP0002396_abnormal_hematopoietic_system	0.47184461
68	MP0002751_abnormal_autonomic_nervous	0.45919482
69	MP0004145_abnormal_muscle_electrophysio	0.45520700
70	MP0008770_decreased_survivor_rate	0.45170285
71	MP0005360_urolithiasis	0.44169996
72	MP0005377_hearing/vestibular/ear_phenot	0.44051938
73	MP0003878_abnormal_ear_physiology	0.44051938
74	MP0009046_muscle_twitch	0.43271329
75	MP0000383_abnormal_hair_follicle	0.41811360
76	MP0008872_abnormal_physiological_respon	0.41711375
77	MP0002971_abnormal_brown_adipose	0.41239143
78	MP0008874_decreased_physiological_sensi	0.40483674
79	MP0002064_seizures	0.38886963
80	MP0002229_neurodegeneration	0.38763735
81	MP0002733_abnormal_thermal_nociception	0.38636817
82	MP0005076_abnormal_cell_differentiation	0.37775808
83	MP0005379_endocrine/exocrine_gland_phen	0.37434217
84	MP0004130_abnormal_muscle_cell	0.37373353
85	MP0004484_altered_response_of	0.36853209
86	MP0003763_abnormal_thymus_physiology	0.36694656
87	MP0008875_abnormal_xenobiotic_pharmacok	0.34119177
88	MP0002572_abnormal_emotion/affect_behav	0.31598804
89	MP0001661_extended_life_span	0.31561845
90	MP0000377_abnormal_hair_follicle	0.31267385
91	MP0002148_abnormal_hypersensitivity_rea	0.30847527
92	MP0005253_abnormal_eye_physiology	0.29124770
93	MP0000372_irregular_coat_pigmentation	0.28517243
94	MP0003866_abnormal_defecation	0.27823879
95	MP0001968_abnormal_touch/_nociception	0.27799467
96	MP0003959_abnormal_lean_body	0.27580295
97	MP0000470_abnormal_stomach_morphology	0.26282970
98	MP0005620_abnormal_muscle_contractility	0.26168179
99	MP0002106_abnormal_muscle_physiology	0.25999017
100	MP0000026_abnormal_inner_ear	0.24702133

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	9.63452146
2	Focal motor seizures (HP:0011153)	9.44636183
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.54329481
4	Parakeratosis (HP:0001036)	7.27240068
5	Acanthocytosis (HP:0001927)	7.04301635
6	Aplastic anemia (HP:0001915)	5.85691374
7	Dialeptic seizures (HP:0011146)	4.68168081
8	Proximal amyotrophy (HP:0007126)	4.51448871
9	Congenital ichthyosiform erythroderma (HP:0007431)	4.35728532
10	Pancreatic cysts (HP:0001737)	4.25290122
11	Colon cancer (HP:0003003)	4.22574039
12	Rectal prolapse (HP:0002035)	3.99443183
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.90468501
14	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.88305676
15	Focal seizures (HP:0007359)	3.79061870
16	Potter facies (HP:0002009)	3.74928335
17	Facial shape deformation (HP:0011334)	3.74928335
18	Vertebral arch anomaly (HP:0008438)	3.65087659
19	Erythroderma (HP:0001019)	3.58696209
20	Scapular winging (HP:0003691)	3.53201833
21	Spontaneous hematomas (HP:0007420)	3.48140783
22	Hematochezia (HP:0002573)	3.43785445
23	Difficulty walking (HP:0002355)	3.43192794
24	Poikilocytosis (HP:0004447)	3.28385863
25	Abnormality of the renal cortex (HP:0011035)	3.20556472
26	Radial bowing (HP:0002986)	3.18393858
27	Pendular nystagmus (HP:0012043)	3.09904534
28	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.07681138
29	Ulnar claw (HP:0001178)	3.07018734
30	Stomach cancer (HP:0012126)	3.03630424
31	Overlapping toe (HP:0001845)	3.00219816
32	Enlarged kidneys (HP:0000105)	2.97690974
33	Type I transferrin isoform profile (HP:0003642)	2.97585371
34	Conjunctival telangiectasia (HP:0000524)	2.88325977
35	IgM deficiency (HP:0002850)	2.78825638
36	Bilateral sensorineural hearing impairment (HP:0008619)	2.78612432
37	Esophageal varix (HP:0002040)	2.76187240
38	Ulnar bowing (HP:0003031)	2.72837115
39	Abnormality of the vocal cords (HP:0008777)	2.63692005
40	Progressive inability to walk (HP:0002505)	2.61636458
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.59039118
42	Type II lissencephaly (HP:0007260)	2.53725597
43	Hypoplastic iliac wings (HP:0002866)	2.50781750
44	Cerebellar dysplasia (HP:0007033)	2.44426786
45	Gangrene (HP:0100758)	2.43617945
46	Synostosis of carpal bones (HP:0005048)	2.41076191
47	Decreased circulating renin level (HP:0003351)	2.39204727
48	Petechiae (HP:0000967)	2.33005576
49	Tubulointerstitial fibrosis (HP:0005576)	2.29297215
50	Broad ribs (HP:0000885)	2.29255325
51	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.27655390
52	Abnormality of the renal medulla (HP:0100957)	2.26408874
53	Abnormality of the shoulder girdle musculature (HP:0001435)	2.24093320
54	Cystic liver disease (HP:0006706)	2.23942755
55	Hypokalemia (HP:0002900)	2.22704176
56	Autoimmune hemolytic anemia (HP:0001890)	2.21273304
57	Hypoalbuminemia (HP:0003073)	2.19628109
58	Abnormal albumin level (HP:0012116)	2.19628109
59	Congenital stationary night blindness (HP:0007642)	2.17857818
60	Inability to walk (HP:0002540)	2.15205396
61	Dehydration (HP:0001944)	2.12457634
62	Portal hypertension (HP:0001409)	2.11468353
63	Abnormality of macular pigmentation (HP:0008002)	2.09138231
64	Tubular atrophy (HP:0000092)	2.04967390
65	Tarsal synostosis (HP:0008368)	2.04183815
66	Severe visual impairment (HP:0001141)	2.02523279
67	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.02000322
68	Chronic diarrhea (HP:0002028)	2.01896322
69	Pancreatic fibrosis (HP:0100732)	1.98477073
70	Albinism (HP:0001022)	1.97388199
71	Pancytopenia (HP:0001876)	1.96255345
72	Abnormality of potassium homeostasis (HP:0011042)	1.94690214
73	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.94127148
74	Abnormality of the hepatic vasculature (HP:0006707)	1.92927258
75	Opisthotonus (HP:0002179)	1.90910396
76	Synostosis involving bones of the lower limbs (HP:0009138)	1.89338083
77	Synostosis involving bones of the feet (HP:0009140)	1.89338083
78	Bowed forearm bones (HP:0003956)	1.88721766
79	Bowing of the arm (HP:0006488)	1.88721766
80	Lack of skin elasticity (HP:0100679)	1.88336925
81	Gastrointestinal stroma tumor (HP:0100723)	1.87735194
82	Palpitations (HP:0001962)	1.87186396
83	Abnormal protein N-linked glycosylation (HP:0012347)	1.87094216
84	Abnormal protein glycosylation (HP:0012346)	1.87094216
85	Abnormal glycosylation (HP:0012345)	1.87094216
86	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87094216
87	Recurrent sinusitis (HP:0011108)	1.85582474
88	Neoplasm of the colon (HP:0100273)	1.83136938
89	Colitis (HP:0002583)	1.81249347
90	Palmoplantar keratoderma (HP:0000982)	1.80405603
91	Nephronophthisis (HP:0000090)	1.78301448
92	Peripheral hypomyelination (HP:0007182)	1.73032883
93	Aortic valve stenosis (HP:0001650)	1.72931852
94	Retinitis pigmentosa (HP:0000510)	1.72429459
95	Horizontal nystagmus (HP:0000666)	1.69296518
96	Carpal bone hypoplasia (HP:0001498)	1.64576549
97	Prostate neoplasm (HP:0100787)	1.62660432
98	Thickened calvaria (HP:0002684)	1.62121193
99	Lipoatrophy (HP:0100578)	1.60553382
100	Purpura (HP:0000979)	1.59415611

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.37570183
2	LATS2	6.30882993
3	ZAK	3.47746147
4	MAP2K2	2.71616251
5	PRKD3	2.63768626
6	FRK	2.45809306
7	STK38	2.41465862
8	ACVR1B	2.38708840
9	TAOK3	2.32497802
10	STK3	2.20464174
11	NLK	2.17774023
12	LATS1	10.4264486
13	MELK	1.70177080
14	BMPR1B	1.57713913
15	GRK5	1.35545614
16	NEK2	1.06735066
17	EIF2AK3	1.04729735
18	TAF1	1.02348988
19	PIK3CG	1.02206108
20	PRKAA2	0.95227555
21	KSR2	0.93739755
22	GRK7	0.92820776
23	PDPK1	0.83973853
24	IRAK3	0.77546388
25	MAP3K2	0.77355039
26	TGFBR2	0.76887482
27	MAPKAPK3	0.75069150
28	CSNK1A1L	0.72125904
29	TGFBR1	0.71485459
30	ADRBK2	0.67741286
31	NEK9	0.67131268
32	MOS	0.66839737
33	PINK1	0.66671250
34	MAP2K1	0.61585376
35	DAPK2	0.59531541
36	ADRBK1	0.56835648
37	PIM1	0.55896164
38	PRKD1	0.46818654
39	NUAK1	0.46729273
40	DAPK1	0.43967895
41	EIF2AK2	0.40686183
42	TTK	0.40619103
43	STK10	0.40506329
44	NME1	0.34476613
45	STK11	0.34411829
46	VRK2	0.34288961
47	TLK1	0.31646135
48	CHEK2	0.31210142
49	PRKCI	0.27379408
50	IRAK2	0.26393301
51	TNK2	0.26312349
52	GRK1	0.25833518
53	IKBKB	0.22283377
54	PLK1	0.21823477
55	GRK6	0.21600034
56	TXK	0.21545878
57	IRAK4	0.20457661
58	WNK4	0.19012711
59	ITK	0.17514264
60	CSNK1D	0.17456884
61	VRK1	0.15790371
62	OXSR1	0.14361305
63	NEK1	0.13965416
64	MAP2K7	0.12028184
65	MAPK7	0.12005778
66	STK24	0.10662597
67	BUB1	0.09582069
68	MAP3K7	0.09328607
69	ABL1	0.07969250
70	JAK2	0.07824647
71	MAPK3	0.07573443
72	STK39	0.07275172
73	IKBKE	0.06309543
74	MAPKAPK5	0.06260180
75	TEC	0.05604347
76	LMTK2	0.05575266
77	TESK2	0.05438239
78	PRKACA	0.04732458
79	PLK3	0.04339175
80	PRKCE	0.03910358
81	MAP3K4	0.03881672
82	AKT2	0.03147359
83	CDK3	0.02983216
84	CAMK2B	0.02600480
85	FER	0.02467492
86	MAPK1	0.00976483
87	MAP3K1	0.00274878
88	MATK	-0.0453525
89	PRKCG	-0.0443609
90	PRKG2	-0.0390806
91	MAP3K14	-0.0359843
92	ATR	-0.0351965
93	CCNB1	-0.0272055
94	CSNK1A1	-0.0233840
95	CHUK	-0.0219473
96	PRKCH	-0.0182065
97	IRAK1	-0.0157807
98	PTK2B	-0.0151206
99	WNK3	-0.0080313
100	CAMK2A	-0.0037984

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	9.39359028
2	Phototransduction_Homo sapiens_hsa04744	4.49371586
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.82850810
4	Sphingolipid metabolism_Homo sapiens_hsa00600	3.71708734
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.32062949
6	Nicotine addiction_Homo sapiens_hsa05033	2.74446770
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.49348408
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.26873111
9	Taste transduction_Homo sapiens_hsa04742	2.15126031
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.95190556
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.89886846
12	Morphine addiction_Homo sapiens_hsa05032	1.87880241
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.87327906
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64974528
15	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.52589567
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.50571688
17	One carbon pool by folate_Homo sapiens_hsa00670	1.49877914
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48770528
19	Histidine metabolism_Homo sapiens_hsa00340	1.39744047
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33303699
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.25607402
22	GABAergic synapse_Homo sapiens_hsa04727	1.19805045
23	Viral myocarditis_Homo sapiens_hsa05416	1.09913015
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06759252
25	Calcium signaling pathway_Homo sapiens_hsa04020	1.04418815
26	Tyrosine metabolism_Homo sapiens_hsa00350	1.02510384
27	ABC transporters_Homo sapiens_hsa02010	0.99773913
28	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.99466523
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98192178
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97225775
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93680988
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.91473708
33	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.89155920
34	Serotonergic synapse_Homo sapiens_hsa04726	0.79604531
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73698170
36	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72792284
37	Butanoate metabolism_Homo sapiens_hsa00650	0.71059082
38	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.68896004
39	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.66823924
40	Basal transcription factors_Homo sapiens_hsa03022	0.65499398
41	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.61558391
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61134403
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59215079
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.58742388
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.56753533
46	Bile secretion_Homo sapiens_hsa04976	0.56736981
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55298731
48	VEGF signaling pathway_Homo sapiens_hsa04370	0.54568132
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.54015762
50	Colorectal cancer_Homo sapiens_hsa05210	0.53788249
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53432648
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50429348
53	Homologous recombination_Homo sapiens_hsa03440	0.48992490
54	Retinol metabolism_Homo sapiens_hsa00830	0.44265888
55	Olfactory transduction_Homo sapiens_hsa04740	0.44161785
56	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.44005424
57	Adherens junction_Homo sapiens_hsa04520	0.43035594
58	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42868940
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42443547
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41649469
61	Fatty acid degradation_Homo sapiens_hsa00071	0.41428544
62	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.40628719
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39748067
64	Salivary secretion_Homo sapiens_hsa04970	0.39261963
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.38622036
66	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.37423722
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36710238
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.34063292
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.33192077
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33076894
71	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32529745
72	Hippo signaling pathway_Homo sapiens_hsa04390	0.32176631
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31009015
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.30721302
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.28819032
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28338495
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27899302
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27558172
79	African trypanosomiasis_Homo sapiens_hsa05143	0.27258193
80	Fanconi anemia pathway_Homo sapiens_hsa03460	0.26301529
81	Thyroid cancer_Homo sapiens_hsa05216	0.24976070
82	Asthma_Homo sapiens_hsa05310	0.24054649
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22789059
84	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22561867
85	Tuberculosis_Homo sapiens_hsa05152	0.22232981
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.22092926
87	Metabolic pathways_Homo sapiens_hsa01100	0.21296375
88	Cell cycle_Homo sapiens_hsa04110	0.19174620
89	Circadian entrainment_Homo sapiens_hsa04713	0.18285399
90	Peroxisome_Homo sapiens_hsa04146	0.18017411
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.16009804
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.14916798
93	Folate biosynthesis_Homo sapiens_hsa00790	0.14860845
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.13256587
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.12963257
96	Oocyte meiosis_Homo sapiens_hsa04114	0.12142687
97	Gastric acid secretion_Homo sapiens_hsa04971	0.11150081
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.10284437
99	Melanogenesis_Homo sapiens_hsa04916	0.09812144
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.09539797

COX4I1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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