ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	6.97442905
2	nucleoside transmembrane transport (GO:1901642)	5.41118131
3	GDP-mannose metabolic process (GO:0019673)	4.90774320
4	peptidyl-histidine modification (GO:0018202)	4.90069413
5	mannose metabolic process (GO:0006013)	4.80340740
6	response to pheromone (GO:0019236)	4.37060767
7	male meiosis I (GO:0007141)	4.30373552
8	synapsis (GO:0007129)	4.24045815
9	ribosomal small subunit assembly (GO:0000028)	4.23066763
10	nucleoside transport (GO:0015858)	4.10346162
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.08514518
12	ATP synthesis coupled proton transport (GO:0015986)	4.08514518
13	respiratory chain complex IV assembly (GO:0008535)	4.00917844
14	protein complex biogenesis (GO:0070271)	3.92748862
15	piRNA metabolic process (GO:0034587)	3.88843073
16	ribosomal small subunit biogenesis (GO:0042274)	3.84844041
17	cytochrome complex assembly (GO:0017004)	3.84482422
18	lipopolysaccharide biosynthetic process (GO:0009103)	3.71170140
19	ribonucleoprotein complex disassembly (GO:0032988)	3.67537343
20	protein polyglutamylation (GO:0018095)	3.64736295
21	peroxisome fission (GO:0016559)	3.63409015
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.57037101
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.57037101
24	DNA deamination (GO:0045006)	3.55480050
25	negative regulation of mast cell activation (GO:0033004)	3.53690531
26	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.47566779
27	negative regulation of telomere maintenance (GO:0032205)	3.45724024
28	L-fucose catabolic process (GO:0042355)	3.43786612
29	fucose catabolic process (GO:0019317)	3.43786612
30	L-fucose metabolic process (GO:0042354)	3.43786612
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.43583809
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.36300757
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.36300757
34	NADH dehydrogenase complex assembly (GO:0010257)	3.36300757
35	cellular ketone body metabolic process (GO:0046950)	3.35130830
36	ubiquinone biosynthetic process (GO:0006744)	3.31056603
37	protein-cofactor linkage (GO:0018065)	3.29777528
38	behavioral response to nicotine (GO:0035095)	3.26777985
39	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.26734091
40	amine catabolic process (GO:0009310)	3.21020447
41	cellular biogenic amine catabolic process (GO:0042402)	3.21020447
42	negative regulation of execution phase of apoptosis (GO:1900118)	3.20733078
43	resolution of meiotic recombination intermediates (GO:0000712)	3.20480766
44	viral transcription (GO:0019083)	3.19188363
45	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.18988228
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.15999180
47	translational elongation (GO:0006414)	3.15361644
48	intracellular protein transmembrane import (GO:0044743)	3.13611592
49	translational termination (GO:0006415)	3.12855241
50	regulation of cilium movement (GO:0003352)	3.12029053
51	deoxyribonucleotide catabolic process (GO:0009264)	3.11528810
52	meiosis I (GO:0007127)	3.10945679
53	ketone body metabolic process (GO:1902224)	3.07671802
54	purine deoxyribonucleotide catabolic process (GO:0009155)	3.07363683
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.07273163
56	ubiquinone metabolic process (GO:0006743)	3.05641796
57	sulfur compound transport (GO:0072348)	3.02731823
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.01554094
59	positive regulation of defense response to virus by host (GO:0002230)	3.00908304
60	protein localization to peroxisome (GO:0072662)	2.99778044
61	protein targeting to peroxisome (GO:0006625)	2.99778044
62	establishment of protein localization to peroxisome (GO:0072663)	2.99778044
63	lipopolysaccharide metabolic process (GO:0008653)	2.98804358
64	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.97336930
65	interferon-gamma production (GO:0032609)	2.93261524
66	cellular biogenic amine biosynthetic process (GO:0042401)	2.93258763
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.93131578
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.91936891
69	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.90371894
70	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.90359380
71	regulation of meiosis I (GO:0060631)	2.90148980
72	pantothenate metabolic process (GO:0015939)	2.90145515
73	indolalkylamine metabolic process (GO:0006586)	2.90130458
74	male meiosis (GO:0007140)	2.86744984
75	reciprocal meiotic recombination (GO:0007131)	2.86323039
76	reciprocal DNA recombination (GO:0035825)	2.86323039
77	cofactor transport (GO:0051181)	2.84073260
78	short-chain fatty acid metabolic process (GO:0046459)	2.82637749
79	amine biosynthetic process (GO:0009309)	2.81255784
80	reproduction (GO:0000003)	2.80399228
81	coenzyme A biosynthetic process (GO:0015937)	2.80184913
82	metallo-sulfur cluster assembly (GO:0031163)	2.79545566
83	iron-sulfur cluster assembly (GO:0016226)	2.79545566
84	deoxyribose phosphate catabolic process (GO:0046386)	2.79283056
85	forebrain morphogenesis (GO:0048853)	2.77719511
86	pyrimidine nucleotide catabolic process (GO:0006244)	2.74851642
87	positive regulation of prostaglandin secretion (GO:0032308)	2.72686632
88	negative regulation of cAMP-mediated signaling (GO:0043951)	2.72540781
89	positive regulation of icosanoid secretion (GO:0032305)	2.72149873
90	mannosylation (GO:0097502)	2.69369374
91	cell proliferation in forebrain (GO:0021846)	2.66369085
92	amino acid salvage (GO:0043102)	2.66054634
93	L-methionine salvage (GO:0071267)	2.66054634
94	L-methionine biosynthetic process (GO:0071265)	2.66054634
95	modified amino acid transport (GO:0072337)	2.64158893
96	electron transport chain (GO:0022900)	2.63313228
97	positive regulation of fatty acid transport (GO:2000193)	2.62826307
98	preassembly of GPI anchor in ER membrane (GO:0016254)	2.62203708
99	replication fork processing (GO:0031297)	2.61886115
100	respiratory electron transport chain (GO:0022904)	2.61592174

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.06322057
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.88880665
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.61022534
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.47261507
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.24808602
6	VDR_22108803_ChIP-Seq_LS180_Human	3.11517969
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.09846731
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.06854125
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.51787423
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.33308811
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.30408923
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29895302
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28400049
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.25759885
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.08338185
16	TP53_22573176_ChIP-Seq_HFKS_Human	1.95256157
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.93669005
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.93306893
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93011919
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.92832194
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.79993845
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.77301762
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74950886
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.67582853
25	FUS_26573619_Chip-Seq_HEK293_Human	1.66743379
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66435438
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.64699088
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62833099
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.61778430
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60011415
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.58800807
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58395943
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57752844
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55072556
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.53968764
36	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.52715157
37	EWS_26573619_Chip-Seq_HEK293_Human	1.52190867
38	P300_19829295_ChIP-Seq_ESCs_Human	1.47684246
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.44515986
40	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.44281964
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42431150
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.41822691
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33971753
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33971753
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33745962
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33217849
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.28145347
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.27923459
49	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.24725207
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22963375
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21820460
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.21228003
53	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.20411316
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20151659
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20151659
56	AR_20517297_ChIP-Seq_VCAP_Human	1.18778239
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17552375
58	MYC_19829295_ChIP-Seq_ESCs_Human	1.16103627
59	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15387703
60	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.15304976
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11912187
62	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10737284
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10334628
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09442173
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08340404
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07724627
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07724627
68	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04789952
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04770835
70	RBPJ_21746931_ChIP-Seq_IB4_Human	1.04218632
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.03998798
72	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03411231
73	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.03222453
74	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02561052
75	GATA3_26560356_Chip-Seq_TH2_Human	1.02200825
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02131401
77	PHF8_20622853_ChIP-Seq_HELA_Human	1.01722553
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.01616893
79	GABP_19822575_ChIP-Seq_HepG2_Human	1.01423699
80	OCT4_20526341_ChIP-Seq_ESCs_Human	0.98829196
81	STAT3_23295773_ChIP-Seq_U87_Human	0.98339000
82	ETV1_20927104_ChIP-Seq_GIST48_Human	0.97498877
83	KDM5A_27292631_Chip-Seq_BREAST_Human	0.96168040
84	BCAT_22108803_ChIP-Seq_LS180_Human	0.96163198
85	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.95650878
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94724029
87	TCF4_23295773_ChIP-Seq_U87_Human	0.93781453
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92950078
89	CDX2_22108803_ChIP-Seq_LS180_Human	0.92693069
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92498837
91	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91519181
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.90807591
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90729514
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89712030
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88040301
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87864046
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.87049331
98	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.86735245
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.86735245
100	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.86648787

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.99824991
2	MP0002102_abnormal_ear_morphology	3.68966013
3	MP0002638_abnormal_pupillary_reflex	3.58577138
4	MP0009379_abnormal_foot_pigmentation	2.91664825
5	MP0006292_abnormal_olfactory_placode	2.70632030
6	MP0002876_abnormal_thyroid_physiology	2.48619657
7	MP0008877_abnormal_DNA_methylation	2.45898330
8	MP0003136_yellow_coat_color	2.41225341
9	MP0005379_endocrine/exocrine_gland_phen	2.28846960
10	MP0001986_abnormal_taste_sensitivity	2.26812206
11	MP0002277_abnormal_respiratory_mucosa	2.17904262
12	MP0008875_abnormal_xenobiotic_pharmacok	2.07386177
13	MP0003011_delayed_dark_adaptation	2.06814876
14	MP0002837_dystrophic_cardiac_calcinosis	2.03490989
15	MP0002160_abnormal_reproductive_system	2.03124065
16	MP0002163_abnormal_gland_morphology	1.98360479
17	MP0003195_calcinosis	1.96867462
18	MP0008995_early_reproductive_senescence	1.89288463
19	MP0002653_abnormal_ependyma_morphology	1.88671079
20	MP0002095_abnormal_skin_pigmentation	1.86293462
21	MP0005174_abnormal_tail_pigmentation	1.79213653
22	MP0005377_hearing/vestibular/ear_phenot	1.79098179
23	MP0003878_abnormal_ear_physiology	1.79098179
24	MP0006072_abnormal_retinal_apoptosis	1.74951461
25	MP0001485_abnormal_pinna_reflex	1.68377767
26	MP0001529_abnormal_vocalization	1.64558636
27	MP0005645_abnormal_hypothalamus_physiol	1.63141368
28	MP0000015_abnormal_ear_pigmentation	1.57669788
29	MP0001661_extended_life_span	1.56795835
30	MP0003787_abnormal_imprinting	1.54320186
31	MP0000427_abnormal_hair_cycle	1.52454697
32	MP0005551_abnormal_eye_electrophysiolog	1.51923539
33	MP0005084_abnormal_gallbladder_morpholo	1.49116088
34	MP0005389_reproductive_system_phenotype	1.45242769
35	MP0005253_abnormal_eye_physiology	1.45050797
36	MP0002210_abnormal_sex_determination	1.42035741
37	MP0006276_abnormal_autonomic_nervous	1.39050123
38	MP0000569_abnormal_digit_pigmentation	1.38509576
39	MP0003880_abnormal_central_pattern	1.35955848
40	MP0002938_white_spotting	1.33477683
41	MP0002249_abnormal_larynx_morphology	1.32823007
42	MP0000372_irregular_coat_pigmentation	1.31749893
43	MP0001502_abnormal_circadian_rhythm	1.31446961
44	MP0001968_abnormal_touch/_nociception	1.31120061
45	MP0005646_abnormal_pituitary_gland	1.28019298
46	MP0001348_abnormal_lacrimal_gland	1.26813021
47	MP0002127_abnormal_cardiovascular_syste	1.24372412
48	MP0000778_abnormal_nervous_system	1.22072458
49	MP0002735_abnormal_chemical_nociception	1.21533375
50	MP0002234_abnormal_pharynx_morphology	1.18897044
51	MP0005365_abnormal_bile_salt	1.17920182
52	MP0004142_abnormal_muscle_tone	1.16795739
53	MP0008775_abnormal_heart_ventricle	1.16754547
54	MP0003698_abnormal_male_reproductive	1.16055484
55	MP0001764_abnormal_homeostasis	1.14787884
56	MP0002282_abnormal_trachea_morphology	1.14234219
57	MP0008058_abnormal_DNA_repair	1.13459851
58	MP0005503_abnormal_tendon_morphology	1.11327281
59	MP0001905_abnormal_dopamine_level	1.09571653
60	MP0001929_abnormal_gametogenesis	1.07426947
61	MP0000049_abnormal_middle_ear	1.05894718
62	MP0005075_abnormal_melanosome_morpholog	1.05276840
63	MP0008872_abnormal_physiological_respon	1.04113729
64	MP0002736_abnormal_nociception_after	0.99871521
65	MP0005083_abnormal_biliary_tract	0.99552408
66	MP0002272_abnormal_nervous_system	0.99011524
67	MP0000653_abnormal_sex_gland	0.98571797
68	MP0008789_abnormal_olfactory_epithelium	0.97588193
69	MP0004133_heterotaxia	0.97537137
70	MP0001145_abnormal_male_reproductive	0.97271992
71	MP0000631_abnormal_neuroendocrine_gland	0.93400184
72	MP0000026_abnormal_inner_ear	0.91566429
73	MP0004043_abnormal_pH_regulation	0.89110151
74	MP0003786_premature_aging	0.87441550
75	MP0002572_abnormal_emotion/affect_behav	0.87114118
76	MP0001293_anophthalmia	0.85957863
77	MP0005410_abnormal_fertilization	0.85285114
78	MP0002928_abnormal_bile_duct	0.85202940
79	MP0003806_abnormal_nucleotide_metabolis	0.85018720
80	MP0002733_abnormal_thermal_nociception	0.84843547
81	MP0004924_abnormal_behavior	0.84798815
82	MP0005386_behavior/neurological_phenoty	0.84798815
83	MP0001486_abnormal_startle_reflex	0.84262930
84	MP0002752_abnormal_somatic_nervous	0.82540654
85	MP0009046_muscle_twitch	0.82420273
86	MP0001542_abnormal_bone_strength	0.82073995
87	MP0002177_abnormal_outer_ear	0.82020388
88	MP0001984_abnormal_olfaction	0.81908688
89	MP0003123_paternal_imprinting	0.81249883
90	MP0003183_abnormal_peptide_metabolism	0.79307934
91	MP0001270_distended_abdomen	0.79081404
92	MP0000647_abnormal_sebaceous_gland	0.78820094
93	MP0002557_abnormal_social/conspecific_i	0.78808742
94	MP0001119_abnormal_female_reproductive	0.78621003
95	MP0001501_abnormal_sleep_pattern	0.77812552
96	MP0000383_abnormal_hair_follicle	0.76520901
97	MP0000678_abnormal_parathyroid_gland	0.76183268
98	MP0009745_abnormal_behavioral_response	0.74630715
99	MP0000230_abnormal_systemic_arterial	0.71018172
100	MP0001963_abnormal_hearing_physiology	0.69309399

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.15258123
2	Pancreatic cysts (HP:0001737)	3.39924539
3	Increased CSF lactate (HP:0002490)	3.37645843
4	Nephronophthisis (HP:0000090)	3.35078393
5	Global brain atrophy (HP:0002283)	3.31736967
6	Increased hepatocellular lipid droplets (HP:0006565)	3.26366076
7	Congenital stationary night blindness (HP:0007642)	3.26215077
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.24517999
9	Dyskinesia (HP:0100660)	3.22926646
10	Mitochondrial inheritance (HP:0001427)	3.22828114
11	Tubular atrophy (HP:0000092)	3.17610398
12	Lipid accumulation in hepatocytes (HP:0006561)	3.17447561
13	Abnormality of midbrain morphology (HP:0002418)	3.06710885
14	Molar tooth sign on MRI (HP:0002419)	3.06710885
15	Carpal bone hypoplasia (HP:0001498)	3.04793615
16	Methylmalonic acidemia (HP:0002912)	3.04183563
17	Hepatocellular necrosis (HP:0001404)	2.87573701
18	Hepatic necrosis (HP:0002605)	2.86350087
19	Neurodegeneration (HP:0002180)	2.85944049
20	Abnormality of the renal medulla (HP:0100957)	2.84091169
21	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.83526685
22	Pancreatic fibrosis (HP:0100732)	2.83456336
23	Delayed CNS myelination (HP:0002188)	2.78282258
24	Renal Fanconi syndrome (HP:0001994)	2.76336866
25	Abnormality of the renal cortex (HP:0011035)	2.74437501
26	Brushfield spots (HP:0001088)	2.65520368
27	Acute necrotizing encephalopathy (HP:0006965)	2.55838656
28	Rib fusion (HP:0000902)	2.54015172
29	Small epiphyses (HP:0010585)	2.47548817
30	CNS demyelination (HP:0007305)	2.45436376
31	Renal cortical cysts (HP:0000803)	2.44441933
32	Abnormal number of erythroid precursors (HP:0012131)	2.44327416
33	Absent thumb (HP:0009777)	2.42435519
34	Tubulointerstitial abnormality (HP:0001969)	2.41049911
35	Abnormality of renal resorption (HP:0011038)	2.39937577
36	True hermaphroditism (HP:0010459)	2.39721547
37	Abnormality of alanine metabolism (HP:0010916)	2.39609278
38	Hyperalaninemia (HP:0003348)	2.39609278
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.39609278
40	Hyperglycinemia (HP:0002154)	2.37280735
41	Type II lissencephaly (HP:0007260)	2.33307724
42	Hypobetalipoproteinemia (HP:0003563)	2.32692178
43	Tachypnea (HP:0002789)	2.28846793
44	Methylmalonic aciduria (HP:0012120)	2.28802979
45	Patent foramen ovale (HP:0001655)	2.27085246
46	Increased serum lactate (HP:0002151)	2.26523755
47	Reticulocytopenia (HP:0001896)	2.25965317
48	Akinesia (HP:0002304)	2.25753467
49	Sclerocornea (HP:0000647)	2.21677359
50	Parakeratosis (HP:0001036)	2.20430444
51	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.19848821
52	Acanthocytosis (HP:0001927)	2.18735709
53	Irregular vertebral endplates (HP:0003301)	2.18497834
54	Attenuation of retinal blood vessels (HP:0007843)	2.16739889
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.14513239
56	Ketoacidosis (HP:0001993)	2.13922091
57	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.13889714
58	Pendular nystagmus (HP:0012043)	2.13458586
59	Hip dysplasia (HP:0001385)	2.12744266
60	Progressive macrocephaly (HP:0004481)	2.12320130
61	Lissencephaly (HP:0001339)	2.11723269
62	Ketosis (HP:0001946)	2.10551619
63	Abnormal mitochondria in muscle tissue (HP:0008316)	2.09149139
64	Chronic hepatic failure (HP:0100626)	2.08195729
65	Flat capital femoral epiphysis (HP:0003370)	2.08046329
66	Opisthotonus (HP:0002179)	2.06477203
67	Abnormality of fatty-acid metabolism (HP:0004359)	2.04613477
68	Septo-optic dysplasia (HP:0100842)	2.02915255
69	Amblyopia (HP:0000646)	2.02885527
70	Respiratory difficulties (HP:0002880)	2.02885053
71	Microretrognathia (HP:0000308)	2.02179489
72	Acute encephalopathy (HP:0006846)	2.01521559
73	Decreased central vision (HP:0007663)	2.01226682
74	Adrenal hypoplasia (HP:0000835)	2.00058996
75	Hypothermia (HP:0002045)	1.98096786
76	Epiphyseal stippling (HP:0010655)	1.96042248
77	Agitation (HP:0000713)	1.95413929
78	Congenital, generalized hypertrichosis (HP:0004540)	1.95241785
79	Stenosis of the external auditory canal (HP:0000402)	1.95234345
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92916238
81	Decreased muscle mass (HP:0003199)	1.91986398
82	Abnormality of urine glucose concentration (HP:0011016)	1.91105308
83	Glycosuria (HP:0003076)	1.91105308
84	Abnormal drinking behavior (HP:0030082)	1.90871357
85	Polydipsia (HP:0001959)	1.90871357
86	Medial flaring of the eyebrow (HP:0010747)	1.86181101
87	Exertional dyspnea (HP:0002875)	1.84734600
88	Irregular epiphyses (HP:0010582)	1.84112924
89	Abnormal epiphyseal ossification (HP:0010656)	1.83352416
90	Severe muscular hypotonia (HP:0006829)	1.82847116
91	Optic disc pallor (HP:0000543)	1.82439359
92	Abnormality of the parathyroid morphology (HP:0011766)	1.81397145
93	Lactic acidosis (HP:0003128)	1.80388423
94	Cystic liver disease (HP:0006706)	1.80038374
95	Impulsivity (HP:0100710)	1.80008328
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.79954403
97	Autoimmune thrombocytopenia (HP:0001973)	1.78126054
98	Febrile seizures (HP:0002373)	1.77851111
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.73955704
100	Increased intramyocellular lipid droplets (HP:0012240)	1.72431158

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	3.97493344
2	FRK	3.33697759
3	STK39	3.11450228
4	WNK4	3.06667550
5	TRIM28	2.71008796
6	PINK1	2.56597282
7	ZAK	2.35815171
8	NUAK1	2.30243565
9	MAP3K4	2.24244690
10	INSRR	2.20446062
11	BMPR2	2.11707032
12	GRK1	1.96128708
13	LIMK1	1.91977977
14	ADRBK2	1.85324620
15	STK16	1.69003720
16	BCKDK	1.55846055
17	PAK3	1.51955435
18	OXSR1	1.50733071
19	WNK3	1.50466179
20	MAP4K2	1.45484062
21	ABL2	1.37459310
22	MAP2K4	1.36525737
23	MAP2K6	1.35042155
24	STK38L	1.28536806
25	BMPR1B	1.23173950
26	PRKCQ	1.20054694
27	DAPK2	1.15878935
28	ADRBK1	1.15639516
29	DYRK2	1.11044900
30	CASK	1.09133538
31	STK38	1.08743448
32	TLK1	1.07965265
33	MAPK13	1.04289066
34	BCR	1.04199856
35	NME1	1.03192329
36	PIK3CA	0.95980078
37	PIK3CG	0.94800723
38	MAP2K7	0.91857345
39	CLK1	0.91021638
40	STK3	0.90201030
41	TEC	0.89928192
42	CAMKK2	0.89053845
43	PRKCE	0.88496083
44	TXK	0.87868335
45	PKN1	0.87184803
46	WNK1	0.86259146
47	CCNB1	0.85932601
48	TNK2	0.82571497
49	GRK7	0.78927470
50	PRKCI	0.77424556
51	MATK	0.76065343
52	EPHA4	0.74961066
53	KIT	0.73195120
54	ATR	0.72664385
55	SRPK1	0.70028974
56	LATS1	0.69822065
57	AKT2	0.68549132
58	PAK2	0.68190051
59	EIF2AK3	0.67364244
60	PRKD2	0.66550583
61	MUSK	0.66348210
62	PRKCG	0.66108283
63	PIM2	0.62121703
64	EGFR	0.62036152
65	CDK8	0.62026973
66	OBSCN	0.61922766
67	LRRK2	0.61381028
68	KDR	0.61199233
69	CAMK1	0.60537020
70	MKNK2	0.58833116
71	AURKA	0.58614447
72	TESK2	0.58261805
73	PLK4	0.58014474
74	PRKCH	0.57589375
75	BRAF	0.57376848
76	CSNK1E	0.56440266
77	ACVR1B	0.56173991
78	MAP3K6	0.55341599
79	LCK	0.55259247
80	TIE1	0.55120179
81	TGFBR1	0.54856886
82	PRKACA	0.54724092
83	NEK1	0.54624430
84	PRKAA2	0.52586899
85	TAOK3	0.51292512
86	IGF1R	0.49207502
87	PRKCA	0.45482644
88	GRK5	0.45308879
89	PASK	0.44979801
90	PLK1	0.44573869
91	CAMK2A	0.43699838
92	PRKD3	0.43122853
93	PLK2	0.40690612
94	MINK1	0.39691349
95	RPS6KA5	0.39535912
96	CSF1R	0.38390492
97	MKNK1	0.37682020
98	INSR	0.37572308
99	NTRK2	0.36003025
100	SYK	0.35437913

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.38097308
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.25635082
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.20836511
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.96812574
5	Parkinsons disease_Homo sapiens_hsa05012	2.56182778
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.30898593
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25004015
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.22949013
9	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.19036026
10	RNA polymerase_Homo sapiens_hsa03020	2.10788305
11	Sulfur metabolism_Homo sapiens_hsa00920	2.09443682
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08374782
13	Phototransduction_Homo sapiens_hsa04744	2.01433027
14	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.92427305
15	Butanoate metabolism_Homo sapiens_hsa00650	1.87084274
16	Alzheimers disease_Homo sapiens_hsa05010	1.84637461
17	Peroxisome_Homo sapiens_hsa04146	1.83535958
18	Sulfur relay system_Homo sapiens_hsa04122	1.82456870
19	Proteasome_Homo sapiens_hsa03050	1.80900394
20	Huntingtons disease_Homo sapiens_hsa05016	1.74841975
21	Caffeine metabolism_Homo sapiens_hsa00232	1.73855152
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.70725655
23	Homologous recombination_Homo sapiens_hsa03440	1.69587810
24	RNA degradation_Homo sapiens_hsa03018	1.63731055
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.52230859
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51913721
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.50464463
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.44147042
29	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.37162352
30	Regulation of autophagy_Homo sapiens_hsa04140	1.32236307
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30695413
32	Asthma_Homo sapiens_hsa05310	1.29347790
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.28390212
34	Protein export_Homo sapiens_hsa03060	1.26220806
35	Taste transduction_Homo sapiens_hsa04742	1.14652414
36	One carbon pool by folate_Homo sapiens_hsa00670	1.12062503
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09319559
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05293497
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.03940766
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.02914244
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00995294
42	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.00172301
43	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.99313132
44	Retinol metabolism_Homo sapiens_hsa00830	0.98020377
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97394274
46	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.96992692
47	Basal transcription factors_Homo sapiens_hsa03022	0.96479096
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92333556
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91961919
50	ABC transporters_Homo sapiens_hsa02010	0.90343969
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89779845
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89337964
53	Purine metabolism_Homo sapiens_hsa00230	0.88123495
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87790626
55	Olfactory transduction_Homo sapiens_hsa04740	0.85798674
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84691531
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84312612
58	Metabolic pathways_Homo sapiens_hsa01100	0.83306601
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81968752
60	Propanoate metabolism_Homo sapiens_hsa00640	0.80621360
61	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78358663
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77449466
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77088054
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76519264
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.75155580
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70744639
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69705756
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.68226206
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64365712
70	Nicotine addiction_Homo sapiens_hsa05033	0.62120709
71	Allograft rejection_Homo sapiens_hsa05330	0.60786019
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59992929
73	Serotonergic synapse_Homo sapiens_hsa04726	0.59475696
74	GABAergic synapse_Homo sapiens_hsa04727	0.59139031
75	RNA transport_Homo sapiens_hsa03013	0.58922592
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.56249545
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.56127969
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54521387
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53679667
80	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.51433834
81	Morphine addiction_Homo sapiens_hsa05032	0.51144662
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.50073773
83	Histidine metabolism_Homo sapiens_hsa00340	0.49716684
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.47767708
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.47024930
86	Base excision repair_Homo sapiens_hsa03410	0.46393000
87	Spliceosome_Homo sapiens_hsa03040	0.44550737
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43672177
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.43286888
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42734076
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.42322699
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41949701
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41501084
94	Folate biosynthesis_Homo sapiens_hsa00790	0.40923203
95	Insulin secretion_Homo sapiens_hsa04911	0.37488196
96	Circadian entrainment_Homo sapiens_hsa04713	0.37218971
97	Glutathione metabolism_Homo sapiens_hsa00480	0.34073630
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.31725357
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.27303395
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.24102983

COX4I1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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