COX4I2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.34785665
2regulation of DNA methylation (GO:0044030)6.78805353
3response to parathyroid hormone (GO:0071107)5.75075097
4endocardial cushion morphogenesis (GO:0003203)5.73273569
5response to BMP (GO:0071772)5.65794600
6cellular response to BMP stimulus (GO:0071773)5.65794600
7cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.39759934
8regulation of steroid hormone secretion (GO:2000831)5.31150092
9keratan sulfate catabolic process (GO:0042340)5.27853122
10negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)5.26097292
11cell aggregation (GO:0098743)5.17757151
12cartilage condensation (GO:0001502)5.17757151
13negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.15566079
14regulation of acrosome reaction (GO:0060046)5.11173743
15cardiac myofibril assembly (GO:0055003)4.90870288
16positive regulation of digestive system process (GO:0060456)4.88490171
17regulation of meiosis I (GO:0060631)4.85993734
18mesenchyme morphogenesis (GO:0072132)4.85767039
19positive regulation of endothelial cell differentiation (GO:0045603)4.81754222
20meiotic cell cycle (GO:0051321)4.78594977
21negative regulation of striated muscle cell apoptotic process (GO:0010664)4.77369651
22surfactant homeostasis (GO:0043129)4.75733039
23ganglion development (GO:0061548)4.75376276
24positive regulation of catecholamine secretion (GO:0033605)4.73680829
25sarcomere organization (GO:0045214)4.69277952
26notochord development (GO:0030903)4.63955934
27piRNA metabolic process (GO:0034587)4.61258134
28sympathetic nervous system development (GO:0048485)4.57069768
29body morphogenesis (GO:0010171)4.56557731
30cardiac muscle tissue morphogenesis (GO:0055008)4.52849084
31negative regulation of norepinephrine secretion (GO:0010700)4.43497091
32actin-myosin filament sliding (GO:0033275)4.43386920
33muscle filament sliding (GO:0030049)4.43386920
34oocyte development (GO:0048599)4.38283837
35glycine transport (GO:0015816)4.36688421
36retina vasculature morphogenesis in camera-type eye (GO:0061299)4.32864554
37positive regulation of calcium ion import (GO:0090280)4.32423955
38female gamete generation (GO:0007292)4.31445055
39cellular response to prostaglandin stimulus (GO:0071379)4.26109474
40replacement ossification (GO:0036075)4.25210963
41endochondral ossification (GO:0001958)4.25210963
42regulation of corticosteroid hormone secretion (GO:2000846)4.22773109
43endothelial cell morphogenesis (GO:0001886)4.20318974
44cellular response to zinc ion (GO:0071294)4.19169189
45regulation of cardioblast differentiation (GO:0051890)4.17801618
46positive regulation of gastrulation (GO:2000543)4.17502901
47chondrocyte development (GO:0002063)4.16665554
48enteric nervous system development (GO:0048484)4.14099830
49cell migration involved in heart development (GO:0060973)4.13387391
50muscle tissue morphogenesis (GO:0060415)4.11709881
51myofibril assembly (GO:0030239)4.10654014
52regulation of endothelial cell differentiation (GO:0045601)4.08391814
53regulation of non-canonical Wnt signaling pathway (GO:2000050)4.07776916
54ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.05341094
55relaxation of smooth muscle (GO:0044557)4.04937297
56multicellular organism reproduction (GO:0032504)3.97526106
57heart valve formation (GO:0003188)3.95654996
58retinal cone cell development (GO:0046549)3.93296260
59actin-mediated cell contraction (GO:0070252)3.89822189
60negative regulation of reproductive process (GO:2000242)3.85544091
61paraxial mesoderm development (GO:0048339)3.85033211
62collagen fibril organization (GO:0030199)3.82878389
63regulation of striated muscle cell apoptotic process (GO:0010662)3.79487729
64dopaminergic neuron differentiation (GO:0071542)3.78988071
65atrioventricular valve morphogenesis (GO:0003181)3.72679618
66protein kinase C signaling (GO:0070528)3.72463945
67regulation of cell maturation (GO:1903429)3.71136831
68mesenchymal cell proliferation (GO:0010463)3.70080275
69regulation of cytokine production involved in inflammatory response (GO:1900015)3.69514720
70cAMP biosynthetic process (GO:0006171)3.67693288
71chemical homeostasis within a tissue (GO:0048875)3.64670113
72regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.63592984
73cardiac muscle cell development (GO:0055013)3.63330287
74regulation of female receptivity (GO:0045924)3.59949789
75negative regulation of multicellular organism growth (GO:0040015)3.58972767
76triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.56801696
77neuron fate determination (GO:0048664)3.55844885
78regulation of norepinephrine secretion (GO:0014061)3.54482012
79regulation of heart morphogenesis (GO:2000826)3.52305534
80cardiac cell development (GO:0055006)3.51552026
81primitive streak formation (GO:0090009)3.51234858
82regulation of cardiac muscle cell apoptotic process (GO:0010665)3.50080529
83cartilage development (GO:0051216)3.49222138
84adult heart development (GO:0007512)3.46769596
85outflow tract septum morphogenesis (GO:0003148)3.46383890
86positive regulation of cAMP-mediated signaling (GO:0043950)3.44415787
87positive regulation of cartilage development (GO:0061036)3.43678708
88positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.40655503
89cardiac muscle contraction (GO:0060048)3.40532680
90positive regulation of steroid hormone secretion (GO:2000833)3.40111935
91regulation of gonadotropin secretion (GO:0032276)3.39837727
92ectodermal placode formation (GO:0060788)3.36075281
93regulation of cardioblast proliferation (GO:0003264)3.34208467
94regulation of secondary heart field cardioblast proliferation (GO:0003266)3.34208467
95regulation of sequestering of triglyceride (GO:0010889)3.33364329
96aggressive behavior (GO:0002118)3.33245916
97negative regulation of circadian rhythm (GO:0042754)3.33244253
98diacylglycerol metabolic process (GO:0046339)3.29059807
99cGMP-mediated signaling (GO:0019934)3.27803081
100endothelial tube morphogenesis (GO:0061154)3.27344318
101morphogenesis of an endothelium (GO:0003159)3.27344318
102adrenergic receptor signaling pathway (GO:0071875)3.27054981
103hyperosmotic salinity response (GO:0042538)3.26958180
104response to prostaglandin E (GO:0034695)3.26231345
105heart valve morphogenesis (GO:0003179)3.22356179
106negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21753793
107regulation of steroid hormone biosynthetic process (GO:0090030)3.21067463
108cell proliferation involved in kidney development (GO:0072111)3.20997452
109endocardial cushion development (GO:0003197)3.18153866
110female mating behavior (GO:0060180)3.17693915
111negative regulation of hormone metabolic process (GO:0032351)3.17110511
112triglyceride catabolic process (GO:0019433)3.16858194
113transcytosis (GO:0045056)3.15562791
114embryonic skeletal joint morphogenesis (GO:0060272)3.13865253
115labyrinthine layer development (GO:0060711)3.13531849
116cardiac epithelial to mesenchymal transition (GO:0060317)3.12785326
117coronary vasculature morphogenesis (GO:0060977)3.11903220
118positive regulation of humoral immune response (GO:0002922)3.10824604
119polyol transport (GO:0015791)3.10770729
120positive regulation of uterine smooth muscle contraction (GO:0070474)3.10661577
121positive regulation of reproductive process (GO:2000243)3.10040216
122relaxation of cardiac muscle (GO:0055119)3.06218503
123viral transcription (GO:0019083)3.05713432
124lung vasculature development (GO:0060426)3.02043486
125actomyosin structure organization (GO:0031032)3.01819954
126negative regulation of lipase activity (GO:0060192)3.00751924
127neural crest cell development (GO:0014032)3.00019137
128L-amino acid import (GO:0043092)2.99802371
129post-embryonic morphogenesis (GO:0009886)2.99724586
130DNA methylation involved in gamete generation (GO:0043046)2.99333289
131adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.99104967
132negative regulation of hormone biosynthetic process (GO:0032353)2.98156099
133protein retention in ER lumen (GO:0006621)2.95814100
134regulation of uterine smooth muscle contraction (GO:0070472)2.95341180
135negative regulation of catecholamine secretion (GO:0033604)2.95021226
136oxidative phosphorylation (GO:0006119)2.90674194
137limb bud formation (GO:0060174)2.90183475
138mesenchymal cell development (GO:0014031)2.90141998
139positive regulation of chondrocyte differentiation (GO:0032332)2.89721094
140peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.89012067
141regulation of smooth muscle cell differentiation (GO:0051150)2.88490060
142negative regulation of smooth muscle cell differentiation (GO:0051151)2.88054535
143regulation of integrin-mediated signaling pathway (GO:2001044)2.87797710
144heart trabecula formation (GO:0060347)2.87599253
145regulation of relaxation of muscle (GO:1901077)2.87244521
146positive regulation of extracellular matrix organization (GO:1903055)2.86674961
147regulation of transforming growth factor beta2 production (GO:0032909)2.84613481
148regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.83831339
149male meiosis (GO:0007140)2.83807180
150reproduction (GO:0000003)2.83651302
151regulation of meiosis (GO:0040020)2.82152996
152translational termination (GO:0006415)2.81601816
153regulation of calcium ion import (GO:0090279)2.80774535
154chondrocyte differentiation (GO:0002062)2.79306242
155neutral lipid catabolic process (GO:0046461)2.78277409
156acylglycerol catabolic process (GO:0046464)2.78277409
157actin filament-based movement (GO:0030048)2.76413983
158creatine metabolic process (GO:0006600)2.74969768
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74968385
160bone development (GO:0060348)2.73887351
161sphingomyelin metabolic process (GO:0006684)2.72907068
162otic vesicle formation (GO:0030916)2.72681698
163somite rostral/caudal axis specification (GO:0032525)2.72486932
164positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.71607789
165sleep (GO:0030431)2.71245441
166positive regulation of cardiac muscle tissue development (GO:0055025)2.69790618
167male meiosis I (GO:0007141)2.69277122
168ventricular cardiac muscle cell development (GO:0055015)2.69090578
169positive regulation of triglyceride lipase activity (GO:0061365)2.68453088
170positive regulation of lipoprotein lipase activity (GO:0051006)2.68453088
171phosphorelay signal transduction system (GO:0000160)2.68365786
172negative regulation of muscle contraction (GO:0045932)2.67860087
173brown fat cell differentiation (GO:0050873)2.67342650
174regulation of endocrine process (GO:0044060)2.65281642
175regulation of macrophage chemotaxis (GO:0010758)2.61464203
176regulation of phospholipid biosynthetic process (GO:0071071)2.60887126
177negative regulation of homotypic cell-cell adhesion (GO:0034111)2.59249730
178ventricular septum morphogenesis (GO:0060412)2.58483103
179type B pancreatic cell development (GO:0003323)2.53171646
180positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.52485236
181germ cell migration (GO:0008354)2.51324986
182regulation of spindle organization (GO:0090224)2.50940286
183positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.50807594
184regulation of reproductive process (GO:2000241)2.50343205
185glycogen biosynthetic process (GO:0005978)2.50167560
186glucan biosynthetic process (GO:0009250)2.50167560
187regulation of histone H3-K9 methylation (GO:0051570)2.50015547
188complement activation, alternative pathway (GO:0006957)2.49501580
189parturition (GO:0007567)2.49144260
190negative regulation of retinoic acid receptor signaling pathway (GO:0048387)12.6185315
191regulation of retinoic acid receptor signaling pathway (GO:0048385)10.8422769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.95243032
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.64358706
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.14583622
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.96940145
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.96940145
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.96940145
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.73710986
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.49411459
9GATA1_22025678_ChIP-Seq_K562_Human3.17020594
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89063941
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.77239177
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68054234
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.61586428
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61244972
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.59691105
16CLOCK_20551151_ChIP-Seq_293T_Human2.57262250
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.56978188
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56912922
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.51058378
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.42232134
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39800633
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32919617
23TBX20_22328084_ChIP-Seq_HEART_Mouse2.16609183
24TBX20_22080862_ChIP-Seq_HEART_Mouse2.16609183
25ZNF263_19887448_ChIP-Seq_K562_Human2.11555440
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.10605660
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09542723
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05372199
29EZH2_22144423_ChIP-Seq_EOC_Human12.1312599
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.99671159
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.99064346
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.96166245
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95471185
34E2F7_22180533_ChIP-Seq_HELA_Human1.84391367
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81942695
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81274198
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79649425
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78707291
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.76650739
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.76087577
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74742307
42NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.68515959
43ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.66670467
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.58376496
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58224771
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56414877
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55070877
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51508054
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.50223813
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47199233
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45070372
52ISL1_27105846_Chip-Seq_CPCs_Mouse1.44140831
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.42936595
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42842764
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42331984
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.41858805
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40475143
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.40301910
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37536483
60CTCF_21964334_Chip-Seq_Bcells_Human1.37020445
61MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34337729
62GATA4_21415370_ChIP-Seq_HL-1_Mouse1.33448629
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.33019339
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32470847
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32357470
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31963471
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31441241
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.30486256
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.29256733
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28940281
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26882581
72AR_21909140_ChIP-Seq_LNCAP_Human1.26606157
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26256611
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25337634
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.24679223
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22992125
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22992125
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22648795
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22001209
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21545848
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.19858538
82CSB_26484114_Chip-Seq_FIBROBLAST_Human1.18318027
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18229839
84CJUN_26792858_Chip-Seq_BT549_Human1.16907406
85XRN2_22483619_ChIP-Seq_HELA_Human1.16882921
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16444650
87NANOG_20526341_ChIP-Seq_ESCs_Human1.16279529
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15496320
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15227107
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15099543
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13965289
92SRF_21415370_ChIP-Seq_HL-1_Mouse1.13837826
93CBP_21632823_ChIP-Seq_H3396_Human1.12194912
94GF1_26923725_Chip-Seq_HPCs_Mouse1.10822174
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.10452283
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10437392
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08973678
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08711494
99EGR1_19032775_ChIP-ChIP_M12_Human1.07369658
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07087159
101ELK1_19687146_ChIP-ChIP_HELA_Human1.04700173
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.02525384
103SA1_22415368_ChIP-Seq_MEFs_Mouse1.00629936
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00568417
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00318852
106NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99404905
107TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99088086
108AR_25329375_ChIP-Seq_VCAP_Human0.98674768
109BCAT_22108803_ChIP-Seq_LS180_Human0.97586034
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97489175
111SOX2_20726797_ChIP-Seq_SW620_Human0.96507111
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96119818
113MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95992273
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95002322
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.94057980
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92661346
117TTF2_22483619_ChIP-Seq_HELA_Human0.92424555
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91914181
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91913652
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91863451
121SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90227654
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89539897
123BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89394433
124ETS1_20019798_ChIP-Seq_JURKAT_Human0.88111362
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87600722
126KLF4_19829295_ChIP-Seq_ESCs_Human0.87238268
127ATF3_27146783_Chip-Seq_COLON_Human0.85796851
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85428357
129TBL1_22424771_ChIP-Seq_293T_Human0.84970927
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.84091224
131EZH2_27294783_Chip-Seq_ESCs_Mouse0.83705211
132MYC_22102868_ChIP-Seq_BL_Human0.83517878
133LXR_22158963_ChIP-Seq_LIVER_Mouse0.83318064
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83318012
135RACK7_27058665_Chip-Seq_MCF-7_Human0.82943994
136SMAD_19615063_ChIP-ChIP_OVARY_Human0.82926325
137SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82129727
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80775304
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80218325
140SMAD4_21799915_ChIP-Seq_A2780_Human0.80123471
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80114418
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78113148
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77472106
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77032302
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76826389
146TAL1_26923725_Chip-Seq_HPCs_Mouse0.75517535
147WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74797762
148SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74528619
149STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.73063588
150CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72538810
151CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71814802
152TCF4_23295773_ChIP-Seq_U87_Human0.70283516
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.69337627
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.69317371
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.68985482
156CBP_20019798_ChIP-Seq_JUKART_Human0.68985482
157RXR_22108803_ChIP-Seq_LS180_Human0.67352860
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.67301274
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67301274
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.66921544
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.66667907
162SMC1_22415368_ChIP-Seq_MEFs_Mouse0.66266180
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.66193383
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65495099
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.65482480
166SOX2_21211035_ChIP-Seq_LN229_Human0.65269877

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.29804591
2MP0003123_paternal_imprinting6.01922171
3MP0003122_maternal_imprinting3.83109532
4MP0003646_muscle_fatigue3.58067061
5MP0002638_abnormal_pupillary_reflex3.39943464
6MP0005503_abnormal_tendon_morphology3.36415594
7MP0009379_abnormal_foot_pigmentation3.14510503
8MP0004084_abnormal_cardiac_muscle3.12552226
9MP0003787_abnormal_imprinting3.10669040
10MP0008789_abnormal_olfactory_epithelium3.02044570
11MP0005360_urolithiasis3.00583808
12MP0003136_yellow_coat_color2.99984966
13MP0000751_myopathy2.87380160
14MP0002282_abnormal_trachea_morphology2.86295467
15MP0006292_abnormal_olfactory_placode2.78641309
16MP0000749_muscle_degeneration2.52980805
17MP0004134_abnormal_chest_morphology2.50918844
18MP0005394_taste/olfaction_phenotype2.48805202
19MP0005499_abnormal_olfactory_system2.48805202
20MP0006138_congestive_heart_failure2.46985103
21MP0009840_abnormal_foam_cell2.46055116
22MP0003279_aneurysm2.36644336
23MP0002933_joint_inflammation2.34315206
24MP0010368_abnormal_lymphatic_system2.29914703
25MP0003121_genomic_imprinting2.25136539
26MP0005395_other_phenotype2.24586525
27MP0005670_abnormal_white_adipose2.22385447
28MP0008438_abnormal_cutaneous_collagen2.09663082
29MP0004145_abnormal_muscle_electrophysio1.96649658
30MP0001879_abnormal_lymphatic_vessel1.95537948
31MP0003879_abnormal_hair_cell1.95179266
32MP0004272_abnormal_basement_membrane1.90575694
33MP0009250_abnormal_appendicular_skeleto1.90517644
34MP0002127_abnormal_cardiovascular_syste1.89920575
35MP0004036_abnormal_muscle_relaxation1.88335717
36MP0008775_abnormal_heart_ventricle1.85010528
37MP0005666_abnormal_adipose_tissue1.84239765
38MP0001958_emphysema1.80569419
39MP0000163_abnormal_cartilage_morphology1.80042486
40MP0002234_abnormal_pharynx_morphology1.78374498
41MP0000762_abnormal_tongue_morphology1.76793800
42MP0002139_abnormal_hepatobiliary_system1.76011875
43MP0002972_abnormal_cardiac_muscle1.75456558
44MP0005647_abnormal_sex_gland1.74821849
45MP0003699_abnormal_female_reproductive1.67040157
46MP0009384_cardiac_valve_regurgitation1.62743490
47MP0001270_distended_abdomen1.60757902
48MP0003890_abnormal_embryonic-extraembry1.60215610
49MP0005385_cardiovascular_system_phenoty1.59634189
50MP0001544_abnormal_cardiovascular_syste1.59634189
51MP0005275_abnormal_skin_tensile1.53725072
52MP0003567_abnormal_fetal_cardiomyocyte1.53484221
53MP0008877_abnormal_DNA_methylation1.51654436
54MP0004215_abnormal_myocardial_fiber1.47383472
55MP0005645_abnormal_hypothalamus_physiol1.47011530
56MP0006276_abnormal_autonomic_nervous1.45186430
57MP0002909_abnormal_adrenal_gland1.44958674
58MP0005330_cardiomyopathy1.43402755
59MP0005375_adipose_tissue_phenotype1.43018371
60MP0004085_abnormal_heartbeat1.42150268
61MP0003942_abnormal_urinary_system1.41020090
62MP0002115_abnormal_skeleton_extremities1.40031215
63MP0005410_abnormal_fertilization1.39339342
64MP0004484_altered_response_of1.39061969
65MP0002837_dystrophic_cardiac_calcinosis1.35777830
66MP0004087_abnormal_muscle_fiber1.31267064
67MP0003705_abnormal_hypodermis_morpholog1.31150140
68MP0005508_abnormal_skeleton_morphology1.29383912
69MP0005623_abnormal_meninges_morphology1.29368652
70MP0003566_abnormal_cell_adhesion1.27980706
71MP0002971_abnormal_brown_adipose1.27946328
72MP0005379_endocrine/exocrine_gland_phen1.27880753
73MP0005646_abnormal_pituitary_gland1.27268913
74MP0003959_abnormal_lean_body1.26798030
75MP0000343_altered_response_to1.24748276
76MP0000049_abnormal_middle_ear1.23934666
77MP0010630_abnormal_cardiac_muscle1.21869277
78MP0004130_abnormal_muscle_cell1.17635700
79MP0001502_abnormal_circadian_rhythm1.17044063
80MP0002210_abnormal_sex_determination1.15977263
81MP0002138_abnormal_hepatobiliary_system1.15398782
82MP0004782_abnormal_surfactant_physiolog1.15165470
83MP0003283_abnormal_digestive_organ1.14879859
84MP0010329_abnormal_lipoprotein_level1.14549704
85MP0002106_abnormal_muscle_physiology1.14258261
86MP0010234_abnormal_vibrissa_follicle1.14022555
87MP0005620_abnormal_muscle_contractility1.13486193
88MP0010030_abnormal_orbit_morphology1.11770433
89MP0000230_abnormal_systemic_arterial1.11025637
90MP0002113_abnormal_skeleton_development1.10783025
91MP0000767_abnormal_smooth_muscle1.10521444
92MP0006054_spinal_hemorrhage1.09572392
93MP0009278_abnormal_bone_marrow1.09186728
94MP0001929_abnormal_gametogenesis1.08937053
95MP0002109_abnormal_limb_morphology1.06396533
96MP0005369_muscle_phenotype1.01770329
97MP0000003_abnormal_adipose_tissue1.00018573
98MP0002089_abnormal_postnatal_growth/wei0.99735488
99MP0004510_myositis0.99377802
100MP0003385_abnormal_body_wall0.98943942
101MP0002128_abnormal_blood_circulation0.98724564
102MP0000266_abnormal_heart_morphology0.97539947
103MP0003119_abnormal_digestive_system0.97133610
104MP0000653_abnormal_sex_gland0.95746297
105MP0003186_abnormal_redox_activity0.95519725
106MP0000750_abnormal_muscle_regeneration0.93938773
107MP0005334_abnormal_fat_pad0.93454797
108MP0003941_abnormal_skin_development0.92637767
109MP0003221_abnormal_cardiomyocyte_apopto0.92153891
110MP0003828_pulmonary_edema0.92088479
111MP0006036_abnormal_mitochondrial_physio0.91192714
112MP0003935_abnormal_craniofacial_develop0.88915954
113MP0005388_respiratory_system_phenotype0.88776415
114MP0002133_abnormal_respiratory_system0.88776415
115MP0002161_abnormal_fertility/fecundity0.87846731
116MP0005167_abnormal_blood-brain_barrier0.87065025
117MP0002233_abnormal_nose_morphology0.85938611
118MP0002925_abnormal_cardiovascular_devel0.85461090
119MP0001175_abnormal_lung_morphology0.85370935
120MP0009115_abnormal_fat_cell0.85057465
121MP0001984_abnormal_olfaction0.84450206
122MP0000566_synostosis0.82845394
123MP0005595_abnormal_vascular_smooth0.82249674
124MP0002796_impaired_skin_barrier0.82150540
125MP0001177_atelectasis0.81124999
126MP0001614_abnormal_blood_vessel0.80962394
127MP0000537_abnormal_urethra_morphology0.80080741
128MP0000759_abnormal_skeletal_muscle0.79745378
129MP0005390_skeleton_phenotype0.79615068
130MP0001881_abnormal_mammary_gland0.78540795
131MP0000631_abnormal_neuroendocrine_gland0.78211541
132MP0000747_muscle_weakness0.76101635
133MP0002108_abnormal_muscle_morphology0.75796484
134MP0002295_abnormal_pulmonary_circulatio0.74534643
135MP0005187_abnormal_penis_morphology0.74351690
136MP0003137_abnormal_impulse_conducting0.73931068
137MP0002269_muscular_atrophy0.73874751
138MP0003115_abnormal_respiratory_system0.73509748
139MP0000516_abnormal_urinary_system0.72835217
140MP0005367_renal/urinary_system_phenotyp0.72835217
141MP0003950_abnormal_plasma_membrane0.72140647
142MP0003937_abnormal_limbs/digits/tail_de0.69564110
143MP0002009_preneoplasia0.69494397
144MP0005332_abnormal_amino_acid0.68770954
145MP0002160_abnormal_reproductive_system0.68161929
146MP0002163_abnormal_gland_morphology0.68030869
147MP0004185_abnormal_adipocyte_glucose0.67941134
148MP0001119_abnormal_female_reproductive0.66741827
149MP0008004_abnormal_stomach_pH0.66601563
150MP0000534_abnormal_ureter_morphology0.66282034
151MP0003690_abnormal_glial_cell0.65632841
152MP0002249_abnormal_larynx_morphology0.65434903
153MP0005164_abnormal_response_to0.65084821
154MP0001784_abnormal_fluid_regulation0.61323876

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.87004841
2Irregular epiphyses (HP:0010582)7.75542518
3Vitreoretinal degeneration (HP:0000655)6.63718454
4Hypoplastic ischia (HP:0003175)5.48686214
5Small epiphyses (HP:0010585)5.45490686
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.17837403
7Flat capital femoral epiphysis (HP:0003370)5.09594947
8Cupped ribs (HP:0000887)4.86169902
9Delayed epiphyseal ossification (HP:0002663)4.76758055
10Abnormality of the ischium (HP:0003174)4.75925618
11Abnormal tarsal ossification (HP:0008369)4.70600277
12Axonal loss (HP:0003447)4.47375595
13Supernumerary spleens (HP:0009799)4.25742900
14Muscle stiffness (HP:0003552)4.20358920
15Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.20303496
16Absent epiphyses (HP:0010577)4.20303496
17Bundle branch block (HP:0011710)4.14019910
18Muscle fiber inclusion bodies (HP:0100299)4.12401579
19Genu varum (HP:0002970)4.12201151
20Type 1 muscle fiber predominance (HP:0003803)4.11094386
21Neonatal short-limb short stature (HP:0008921)4.05321830
22Flat acetabular roof (HP:0003180)4.03731161
23Nemaline bodies (HP:0003798)3.92651078
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.92370384
25Osteomalacia (HP:0002749)3.90114950
26Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.84732385
27Abnormality of femoral epiphyses (HP:0006499)3.84732385
28Osteoarthritis (HP:0002758)3.83347856
29Metaphyseal cupping (HP:0003021)3.71085034
30Depressed nasal tip (HP:0000437)3.65467120
31Patent foramen ovale (HP:0001655)3.57415696
32Abnormality of the epiphysis of the femoral head (HP:0010574)3.51626668
33Hyperlipoproteinemia (HP:0010980)3.46475591
34Abnormal foot bone ossification (HP:0010675)3.38311937
35Complement deficiency (HP:0004431)3.30016028
36Abnormality of the femoral head (HP:0003368)3.29619513
37Mild short stature (HP:0003502)3.20966508
38Metaphyseal dysplasia (HP:0100255)3.19297222
39Flattened epiphyses (HP:0003071)3.18837074
40Exercise-induced muscle cramps (HP:0003710)3.17664281
41Septo-optic dysplasia (HP:0100842)3.16706753
42Anterior segment dysgenesis (HP:0007700)3.08852691
43Abnormality of the pubic bones (HP:0003172)3.07181241
44Short tibia (HP:0005736)3.06450417
45Enlarged penis (HP:0000040)3.05612344
46Hyporeflexia of lower limbs (HP:0002600)3.03954719
47Asymmetric septal hypertrophy (HP:0001670)2.98896761
48Torticollis (HP:0000473)2.95425239
49Nausea (HP:0002018)2.94745667
50Absent septum pellucidum (HP:0001331)2.93341149
51Abnormality of the vertebral endplates (HP:0005106)2.89815053
52Short femoral neck (HP:0100864)2.89541340
53Mesomelia (HP:0003027)2.88374939
54EMG: myopathic abnormalities (HP:0003458)2.86172648
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.84901563
56Metaphyseal irregularity (HP:0003025)2.80926887
57Irregular vertebral endplates (HP:0003301)2.78802337
58Neck muscle weakness (HP:0000467)2.76819392
59Hypercortisolism (HP:0001578)2.74381209
60Arthropathy (HP:0003040)2.74060467
61Carpal bone hypoplasia (HP:0001498)2.72725276
62Cholecystitis (HP:0001082)2.67809965
63Abnormal gallbladder physiology (HP:0012438)2.67809965
64Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.66945881
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.66307843
66Hypoplasia of the fovea (HP:0007750)2.62718502
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.62718502
68Impulsivity (HP:0100710)2.62128718
69Abnormality of carpal bone ossification (HP:0006257)2.61285722
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.59407403
71Coxa vara (HP:0002812)2.59353766
72Glossoptosis (HP:0000162)2.59353194
73Heart block (HP:0012722)2.59342868
74Platyspondyly (HP:0000926)2.59002228
75Limited elbow extension (HP:0001377)2.57785530
76Beaking of vertebral bodies (HP:0004568)2.56780581
77Abnormality of the phalanges of the 2nd finger (HP:0009541)2.56739212
78Limited hip movement (HP:0008800)2.55004280
79Abnormality of abdominal situs (HP:0011620)2.54171332
80Abdominal situs inversus (HP:0003363)2.54171332
81Muscle hypertrophy of the lower extremities (HP:0008968)2.53999856
82Male infertility (HP:0003251)2.53566098
83Hip contracture (HP:0003273)2.51764993
84Waddling gait (HP:0002515)2.50969878
85Lip pit (HP:0100267)2.48801883
86Azoospermia (HP:0000027)2.48795813
87Increased connective tissue (HP:0009025)2.48537673
88Increased variability in muscle fiber diameter (HP:0003557)2.46465184
89Abnormality of skeletal muscle fiber size (HP:0012084)2.44224238
90Abnormal atrioventricular conduction (HP:0005150)2.42576038
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41516669
92Abnormal vertebral ossification (HP:0100569)2.39194092
93Protuberant abdomen (HP:0001538)2.38527291
94Maternal diabetes (HP:0009800)2.38244428
95Conjunctival telangiectasia (HP:0000524)2.36257380
96Lumbar hyperlordosis (HP:0002938)2.36158311
97Abnormality of incisor morphology (HP:0011063)2.35698223
98Abnormality of complement system (HP:0005339)2.34152773
99Enlarged epiphyses (HP:0010580)2.33086769
100Exostoses (HP:0100777)2.32114200
101Wrist flexion contracture (HP:0001239)2.30899696
102Craniofacial dystonia (HP:0012179)2.29432995
103Abnormality of the fovea (HP:0000493)2.29340405
104Focal dystonia (HP:0004373)2.29277755
105Gonadotropin excess (HP:0000837)2.28785258
106Abnormality of the septum pellucidum (HP:0007375)2.27544140
107Skin pits (HP:0100276)2.27114162
108Bone cyst (HP:0012062)2.26179332
109Abnormality of the proximal phalanges of the hand (HP:0009834)2.26106411
110Distal lower limb muscle weakness (HP:0009053)2.26091414
111Myotonia (HP:0002486)2.26025062
112Infertility (HP:0000789)2.24026633
113Oligodactyly (hands) (HP:0001180)2.23962272
114Ovoid vertebral bodies (HP:0003300)2.23214673
115Midline defect of the nose (HP:0004122)2.22563520
116Proximal tubulopathy (HP:0000114)2.21355489
117Striae distensae (HP:0001065)2.20722604
118Thoracolumbar scoliosis (HP:0002944)2.20204674
119Abnormality of the phalanges of the hallux (HP:0010057)2.19681070
120Menstrual irregularities (HP:0000858)2.18740533
121Rhabdomyolysis (HP:0003201)2.18671965
122Pulmonary artery stenosis (HP:0004415)2.16230971
123Distal arthrogryposis (HP:0005684)2.15332563
124Premature ovarian failure (HP:0008209)2.14797814
125Abnormality of sulfur amino acid metabolism (HP:0004339)2.13847197
126Myokymia (HP:0002411)2.12274543
127Muscle fiber splitting (HP:0003555)2.12213143
128Cervical subluxation (HP:0003308)2.11950890
129Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11421282
130Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11024780
131Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.10027487
132Hypophosphatemic rickets (HP:0004912)2.09230301
133Aplasia of the musculature (HP:0100854)2.08773507
134Diastasis recti (HP:0001540)2.08121005
135Generalized aminoaciduria (HP:0002909)2.06790757
136Hypoalphalipoproteinemia (HP:0003233)2.05877288
137Facial hemangioma (HP:0000329)2.05815121
138Partial duplication of the phalanx of hand (HP:0009999)2.05305762
139Reticulocytopenia (HP:0001896)2.04701796
140Aplasia/hypoplasia of the femur (HP:0005613)2.03373209
141Sudden death (HP:0001699)2.02472677
142Exercise-induced myalgia (HP:0003738)2.01599929
143Polycythemia (HP:0001901)2.01504532
144Abnormality of the anterior chamber (HP:0000593)2.01356756
145Polar cataract (HP:0010696)2.01053389
146Round ear (HP:0100830)2.01035592
147Abnormal ossification of hand bones (HP:0005921)1.98636641
148Abnormality of the left ventricular outflow tract (HP:0011103)1.98452673
149Subaortic stenosis (HP:0001682)1.98452673
150Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.98379812
151Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98249107
152Abnormality of the calf musculature (HP:0001430)1.97751058
153Vertebral hypoplasia (HP:0008417)1.97133701
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.97133701
155Median cleft lip (HP:0000161)1.97120334
156Abnormality of the phalanges of the 5th finger (HP:0004213)1.96561809
157Shallow orbits (HP:0000586)1.96378459
158Lipoatrophy (HP:0100578)1.95421967
159Abnormal hand bone ossification (HP:0010660)1.95294632
160Abnormality of purine metabolism (HP:0004352)1.94744118
161Thickened calvaria (HP:0002684)1.94696760
162Increased muscle lipid content (HP:0009058)1.94506641
163Radial bowing (HP:0002986)1.94070118
164Systemic lupus erythematosus (HP:0002725)1.93601298
165Stillbirth (HP:0003826)1.92387692
166Micromelia (HP:0002983)1.91941542
167Atrial fibrillation (HP:0005110)1.90803975
168Vascular tortuosity (HP:0004948)1.89562520
169Broad phalanx (HP:0006009)1.89100169
170Myoglobinuria (HP:0002913)1.89067316
171Ventricular tachycardia (HP:0004756)1.87271378
172Prominent supraorbital ridges (HP:0000336)1.86888145
173Barrel-shaped chest (HP:0001552)1.85992278
174Abnormality of the lumbar spine (HP:0100712)1.81561466
175Broad long bones (HP:0005622)1.80194255
176Fibular hypoplasia (HP:0003038)1.78525693
177Decreased circulating renin level (HP:0003351)1.77779505
178Growth hormone excess (HP:0000845)1.75836231
179Sprengel anomaly (HP:0000912)1.73378915
180Hepatoblastoma (HP:0002884)1.72861456
181Supraventricular tachycardia (HP:0004755)1.72783974
182Abnormality of the 2nd finger (HP:0004100)1.72469977
183Calf muscle hypertrophy (HP:0008981)1.71947447
184Flared metaphyses (HP:0003015)1.71889251
185Subacute progressive viral hepatitis (HP:0006572)1.71506269
186Primary atrial arrhythmia (HP:0001692)1.71270706
187Long clavicles (HP:0000890)1.71087531
188Supraventricular arrhythmia (HP:0005115)1.70348772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.51785915
2STK38L5.01437427
3ARAF4.55273765
4MAP3K134.08452403
5OBSCN4.08338511
6DDR24.04587458
7MAP3K93.92213066
8MYLK3.82475045
9MAP3K33.17694771
10TIE13.08911339
11MOS2.91909029
12ZAK2.74587575
13MAPK72.55667435
14TGFBR12.24254439
15EPHB22.03576130
16TESK12.02303117
17TRIB31.92843048
18PIK3CA1.89956494
19LIMK11.87403904
20PIK3CG1.85467504
21CDK91.64346830
22TTN1.63878267
23AKT31.60473287
24TAOK31.59356642
25PHKG21.55782440
26PHKG11.55782440
27PRKG21.54399200
28KSR21.52266756
29PKN21.51735596
30MAP3K101.49609510
31BRAF1.47437835
32PINK11.45773258
33PRKG11.44618789
34PDGFRA1.44387600
35ILK1.43333902
36MKNK11.43127083
37RAF11.42234927
38GRK11.42071839
39PKN11.38036853
40NLK1.33509076
41CDK81.32506588
42PLK21.28308583
43GRK51.26966697
44RIPK11.24674654
45NME11.23700595
46MAPK151.21270171
47BUB11.20798647
48NME21.20558437
49ERBB31.19486980
50BRSK21.19076666
51BMPR1B1.12517100
52TGFBR21.12036795
53STK31.10753314
54MAPKAPK31.09178940
55AURKA1.08171555
56CDK191.08079911
57CDK31.07793095
58CSNK1G31.00161483
59MKNK20.99805689
60PLK40.98393568
61EIF2AK10.95802089
62MAP3K40.94582776
63TTK0.89297167
64MAPK120.87220104
65CSNK1G10.82166745
66PLK30.81836771
67MAP2K10.81607330
68PRKCI0.76994578
69KIT0.76318439
70FLT30.74915740
71LATS10.72476721
72LATS20.71973276
73PRKACB0.71486320
74LMTK20.70927666
75WEE10.70646472
76DMPK0.69226535
77NTRK20.68753939
78MAP2K70.67711095
79MAP3K70.66435101
80TRPM70.66366003
81VRK10.65518220
82PIM10.63822807
83EIF2AK20.61295795
84LRRK20.60986012
85TRIM280.60413753
86PAK20.60325442
87KDR0.59839466
88MELK0.59740669
89NEK60.59602373
90EPHB10.59539107
91ROCK10.58109464
92BCKDK0.57959575
93MAP2K20.57688222
94PRKD10.57244890
95EIF2AK30.56904264
96CAMK2A0.54692278
97DYRK30.54307326
98PTK20.54083494
99CSNK1G20.52751278
100CSNK1A1L0.52059348
101DAPK30.51257308
102MUSK0.48208971
103EPHA40.46399105
104TYRO30.46160210
105EPHA30.45910689
106PRKAA20.44946864
107CDK40.44822334
108CAMK10.44807805
109PTK2B0.44153757
110PDPK10.43849024
111CDK120.42052385
112MAP2K40.41731527
113TAOK20.41410699
114NUAK10.40431045
115PRKCZ0.39071588
116SGK2230.38625567
117SGK4940.38625567
118PRKACG0.38135401
119RPS6KA40.37561586
120ACVR1B0.36894541
121CDK70.36188701
122PDK20.36032733
123BRSK10.35484165
124SRPK10.35460944
125GSK3A0.34697375
126CAMK2D0.34367384
127PDGFRB0.34125365
128AURKB0.33462140
129PIM20.33299685
130MAP2K30.32496028
131ROCK20.32222195
132CAMK2G0.32135990
133MAPK40.31200136
134AKT20.30381042
135CDC42BPA0.28685035
136IRAK10.28349166
137RPS6KA10.28082225
138TEC0.27912534
139PRKD30.26752028
140CASK0.26682567
141PAK10.26296131
142MARK30.25405544
143FER0.25310261
144PRKACA0.24885870
145PLK10.24468142
146ABL20.24021152
147DYRK1A0.23935784
148CSNK2A10.20910692
149NEK90.19639692
150PAK30.17842511
151FGFR10.17585770
152BCR0.16893719
153MET0.16860658

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.74192520
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.73267174
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.72342958
4ECM-receptor interaction_Homo sapiens_hsa045123.60876407
5Dilated cardiomyopathy_Homo sapiens_hsa054143.43461640
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.28893645
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.91834629
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84927799
9Sulfur relay system_Homo sapiens_hsa041222.82410006
10Parkinsons disease_Homo sapiens_hsa050122.78800967
11* Cardiac muscle contraction_Homo sapiens_hsa042602.70931501
12* Oxidative phosphorylation_Homo sapiens_hsa001902.44326328
13Protein digestion and absorption_Homo sapiens_hsa049742.42484244
14PPAR signaling pathway_Homo sapiens_hsa033202.27388339
15TGF-beta signaling pathway_Homo sapiens_hsa043501.99025966
16Galactose metabolism_Homo sapiens_hsa000521.97460094
17Basal cell carcinoma_Homo sapiens_hsa052171.89163912
18Huntingtons disease_Homo sapiens_hsa050161.87654081
19Focal adhesion_Homo sapiens_hsa045101.82003358
20Circadian rhythm_Homo sapiens_hsa047101.72534404
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69882999
22Oocyte meiosis_Homo sapiens_hsa041141.69798074
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66937313
24Ovarian steroidogenesis_Homo sapiens_hsa049131.63006433
25Alzheimers disease_Homo sapiens_hsa050101.60646810
26Vitamin digestion and absorption_Homo sapiens_hsa049771.59440544
27Hippo signaling pathway_Homo sapiens_hsa043901.55434384
28Ribosome_Homo sapiens_hsa030101.54991254
29RNA polymerase_Homo sapiens_hsa030201.51186905
30Histidine metabolism_Homo sapiens_hsa003401.50557186
31Phenylalanine metabolism_Homo sapiens_hsa003601.47696469
32Fatty acid elongation_Homo sapiens_hsa000621.45735550
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43564238
34DNA replication_Homo sapiens_hsa030301.42510119
35* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34894512
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29032633
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26118210
38Vibrio cholerae infection_Homo sapiens_hsa051101.25913922
39Carbon metabolism_Homo sapiens_hsa012001.25272093
40Olfactory transduction_Homo sapiens_hsa047401.23876135
41Biosynthesis of amino acids_Homo sapiens_hsa012301.23759867
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22360363
43Dorso-ventral axis formation_Homo sapiens_hsa043201.21767040
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.21439715
45HIF-1 signaling pathway_Homo sapiens_hsa040661.20381212
46Proteasome_Homo sapiens_hsa030501.19885998
47Complement and coagulation cascades_Homo sapiens_hsa046101.19591173
48Starch and sucrose metabolism_Homo sapiens_hsa005001.19220021
49Hedgehog signaling pathway_Homo sapiens_hsa043401.15716479
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11722725
51Cell cycle_Homo sapiens_hsa041101.11585101
52Caffeine metabolism_Homo sapiens_hsa002321.09413199
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05876076
54Tyrosine metabolism_Homo sapiens_hsa003501.05375124
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02971056
56Arginine biosynthesis_Homo sapiens_hsa002201.02823063
57Fructose and mannose metabolism_Homo sapiens_hsa000511.02247426
58PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01910784
59Melanogenesis_Homo sapiens_hsa049161.01876086
60Purine metabolism_Homo sapiens_hsa002301.00286637
61Bile secretion_Homo sapiens_hsa049760.98964763
62Base excision repair_Homo sapiens_hsa034100.97365329
63Renin secretion_Homo sapiens_hsa049240.96722098
64Cocaine addiction_Homo sapiens_hsa050300.96623543
65Glutathione metabolism_Homo sapiens_hsa004800.95841163
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95735143
67Arginine and proline metabolism_Homo sapiens_hsa003300.94122613
68RNA transport_Homo sapiens_hsa030130.93655647
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.93644339
70Malaria_Homo sapiens_hsa051440.91650643
71Folate biosynthesis_Homo sapiens_hsa007900.91037474
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90359108
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.90271560
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.87765789
75Morphine addiction_Homo sapiens_hsa050320.86446442
76Thyroid cancer_Homo sapiens_hsa052160.86163697
77Taste transduction_Homo sapiens_hsa047420.85986782
78N-Glycan biosynthesis_Homo sapiens_hsa005100.85225804
79Pyrimidine metabolism_Homo sapiens_hsa002400.85066270
80Glycerolipid metabolism_Homo sapiens_hsa005610.83398902
81Thyroid hormone synthesis_Homo sapiens_hsa049180.82746423
82Pyruvate metabolism_Homo sapiens_hsa006200.82489883
83Notch signaling pathway_Homo sapiens_hsa043300.82172481
84Proteoglycans in cancer_Homo sapiens_hsa052050.80442354
85Amoebiasis_Homo sapiens_hsa051460.80014936
86Linoleic acid metabolism_Homo sapiens_hsa005910.76726280
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76644873
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75995641
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75508872
90Viral myocarditis_Homo sapiens_hsa054160.75499420
91Tight junction_Homo sapiens_hsa045300.75186081
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74077802
93Prion diseases_Homo sapiens_hsa050200.73880110
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73502071
95Fatty acid degradation_Homo sapiens_hsa000710.70025796
96Amphetamine addiction_Homo sapiens_hsa050310.69747384
97Platelet activation_Homo sapiens_hsa046110.69311356
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.68894810
99Spliceosome_Homo sapiens_hsa030400.67524608
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66833515
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66752459
102ABC transporters_Homo sapiens_hsa020100.65656334
103Adherens junction_Homo sapiens_hsa045200.64207168
104Mineral absorption_Homo sapiens_hsa049780.63186431
105Pathways in cancer_Homo sapiens_hsa052000.62838432
106Glucagon signaling pathway_Homo sapiens_hsa049220.62049903
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61851162
108HTLV-I infection_Homo sapiens_hsa051660.61260728
109Chemical carcinogenesis_Homo sapiens_hsa052040.58507222
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.57670275
111Circadian entrainment_Homo sapiens_hsa047130.57046912
112Protein export_Homo sapiens_hsa030600.56327173
113GABAergic synapse_Homo sapiens_hsa047270.56159256
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55721794
115Staphylococcus aureus infection_Homo sapiens_hsa051500.55367129
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54964865
117Pentose phosphate pathway_Homo sapiens_hsa000300.54737636
118Wnt signaling pathway_Homo sapiens_hsa043100.53034731
119Fat digestion and absorption_Homo sapiens_hsa049750.52163412
120Nucleotide excision repair_Homo sapiens_hsa034200.50913328
121One carbon pool by folate_Homo sapiens_hsa006700.50726791
122RNA degradation_Homo sapiens_hsa030180.50182539
123AMPK signaling pathway_Homo sapiens_hsa041520.49307256
124Sphingolipid metabolism_Homo sapiens_hsa006000.48895205
125Gap junction_Homo sapiens_hsa045400.47919393
126Oxytocin signaling pathway_Homo sapiens_hsa049210.47199384
127Serotonergic synapse_Homo sapiens_hsa047260.47152611
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.45733720
129Arachidonic acid metabolism_Homo sapiens_hsa005900.44730489
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.43915541
131Small cell lung cancer_Homo sapiens_hsa052220.42500839
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42251636
133beta-Alanine metabolism_Homo sapiens_hsa004100.41968774
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.41401011
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40749665
136Mismatch repair_Homo sapiens_hsa034300.39971691
137Insulin signaling pathway_Homo sapiens_hsa049100.39720486
138* Metabolic pathways_Homo sapiens_hsa011000.38754331
139Legionellosis_Homo sapiens_hsa051340.37729469
140Insulin resistance_Homo sapiens_hsa049310.37129554
141cAMP signaling pathway_Homo sapiens_hsa040240.36326579
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36093061
143Basal transcription factors_Homo sapiens_hsa030220.35986812
144Propanoate metabolism_Homo sapiens_hsa006400.35638870
145Long-term depression_Homo sapiens_hsa047300.35120296
146Calcium signaling pathway_Homo sapiens_hsa040200.33373901
147Choline metabolism in cancer_Homo sapiens_hsa052310.32278917
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31582992
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30239694
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30056106
151Ras signaling pathway_Homo sapiens_hsa040140.29112169
152Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28402388
153GnRH signaling pathway_Homo sapiens_hsa049120.26230743
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24211059
155Tryptophan metabolism_Homo sapiens_hsa003800.22274424

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »