COX5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.25480139
2ATP synthesis coupled proton transport (GO:0015986)7.70114695
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.70114695
4oxidative phosphorylation (GO:0006119)7.14262485
5* respiratory electron transport chain (GO:0022904)6.64544768
6* electron transport chain (GO:0022900)6.46714266
7tricarboxylic acid cycle (GO:0006099)6.44710546
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.44515532
9ribosomal small subunit biogenesis (GO:0042274)6.26672712
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.60680328
11cotranslational protein targeting to membrane (GO:0006613)5.51482855
12protein targeting to ER (GO:0045047)5.49462494
13chaperone-mediated protein transport (GO:0072321)5.42717932
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.29772677
15protein localization to endoplasmic reticulum (GO:0070972)5.23718412
16maturation of SSU-rRNA (GO:0030490)5.22642501
17viral life cycle (GO:0019058)4.92333710
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.89480358
19cellular protein complex disassembly (GO:0043624)4.89315485
20ATP biosynthetic process (GO:0006754)4.80640362
21ribosomal large subunit biogenesis (GO:0042273)4.68570475
22translational initiation (GO:0006413)4.67394145
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.61820784
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.50378108
25NADH metabolic process (GO:0006734)4.47264863
26protein complex disassembly (GO:0043241)4.24974511
27DNA deamination (GO:0045006)4.22970840
28purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.18796268
29purine nucleoside triphosphate biosynthetic process (GO:0009145)4.16411759
30regulation of acyl-CoA biosynthetic process (GO:0050812)4.14020912
31regulation of cofactor metabolic process (GO:0051193)4.13026903
32regulation of coenzyme metabolic process (GO:0051196)4.13026903
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.10235310
34macromolecular complex disassembly (GO:0032984)4.08988887
35regulation of mitochondrial translation (GO:0070129)4.07289988
36aerobic respiration (GO:0009060)3.97750711
37sarcomere organization (GO:0045214)3.92830084
38carnitine shuttle (GO:0006853)3.91480990
39ribonucleoside triphosphate biosynthetic process (GO:0009201)3.85346413
40quinone biosynthetic process (GO:1901663)3.84277111
41ubiquinone biosynthetic process (GO:0006744)3.84277111
42purine nucleoside monophosphate biosynthetic process (GO:0009127)3.83248049
43purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.83248049
44ribonucleoprotein complex biogenesis (GO:0022613)3.79651845
45cellular component biogenesis (GO:0044085)3.79295741
46protein targeting to membrane (GO:0006612)3.77829168
47lysine metabolic process (GO:0006553)3.76021083
48lysine catabolic process (GO:0006554)3.76021083
49protein neddylation (GO:0045116)3.71189153
50negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.70460777
51actin-myosin filament sliding (GO:0033275)3.69742936
52muscle filament sliding (GO:0030049)3.69742936
53termination of RNA polymerase III transcription (GO:0006386)3.67052235
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.67052235
55succinate metabolic process (GO:0006105)3.65514915
56pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.61720701
57fatty acid transmembrane transport (GO:1902001)3.60959232
58inner mitochondrial membrane organization (GO:0007007)3.60835937
59nucleoside triphosphate biosynthetic process (GO:0009142)3.50422710
60branched-chain amino acid catabolic process (GO:0009083)3.48653525
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48568557
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.48568557
63NADH dehydrogenase complex assembly (GO:0010257)3.48568557
64regulation of cellular respiration (GO:0043457)3.47910058
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.46784201
66mitochondrial transport (GO:0006839)3.45315945
672-deoxyribonucleotide biosynthetic process (GO:0009265)3.43431214
68deoxyribose phosphate biosynthetic process (GO:0046385)3.43431214
69pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.41955292
702-oxoglutarate metabolic process (GO:0006103)3.40821140
71protein complex biogenesis (GO:0070271)3.38639327
72ribosomal small subunit assembly (GO:0000028)3.38380327
73mitochondrial respiratory chain complex assembly (GO:0033108)3.37666177
74heart process (GO:0003015)3.35218704
75heart contraction (GO:0060047)3.35218704
76negative regulation of ligase activity (GO:0051352)3.35096961
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.35096961
78pyrimidine nucleotide catabolic process (GO:0006244)3.34919292
79ribonucleoside monophosphate biosynthetic process (GO:0009156)3.34718199
80cellular respiration (GO:0045333)3.33666744
81fatty acid beta-oxidation (GO:0006635)3.32074482
82* hydrogen ion transmembrane transport (GO:1902600)3.29406985
83telomere maintenance via semi-conservative replication (GO:0032201)3.28759219
84mRNA catabolic process (GO:0006402)3.28186047
85establishment of protein localization to mitochondrial membrane (GO:0090151)3.27930870
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.27577062
87ubiquinone metabolic process (GO:0006743)3.27026693
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26180102
89nucleoside monophosphate biosynthetic process (GO:0009124)3.24582620
90nucleoside diphosphate biosynthetic process (GO:0009133)3.22723661
91cellular ketone body metabolic process (GO:0046950)3.22606227
92proteasome assembly (GO:0043248)3.21889780
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21403196
94negative regulation of potassium ion transmembrane transport (GO:1901380)3.19554177
95oxaloacetate metabolic process (GO:0006107)3.18458616
96regulation of sulfur metabolic process (GO:0042762)3.18148148
97nucleobase-containing small molecule interconversion (GO:0015949)3.17082837
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17048581
99DNA strand elongation involved in DNA replication (GO:0006271)3.16430029
100spliceosomal snRNP assembly (GO:0000387)3.12795422
101viral transcription (GO:0019083)3.11461298
102cytochrome complex assembly (GO:0017004)3.10947095
103pseudouridine synthesis (GO:0001522)3.10567390
104positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.10095268
105* hydrogen transport (GO:0006818)3.09789527
106pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.09520975
107RNA catabolic process (GO:0006401)3.08462641
108cardiac muscle cell development (GO:0055013)3.08005340
109GTP biosynthetic process (GO:0006183)3.07845697
110translational termination (GO:0006415)3.07663916
111aspartate family amino acid catabolic process (GO:0009068)3.07196383
112rRNA processing (GO:0006364)3.06752709
113cardiac muscle contraction (GO:0060048)3.05058740
114establishment of protein localization to mitochondrion (GO:0072655)3.04120357
115DNA strand elongation (GO:0022616)3.02501355
116branched-chain amino acid metabolic process (GO:0009081)3.02453488
117carnitine transmembrane transport (GO:1902603)3.02142887
118protein targeting to mitochondrion (GO:0006626)3.01896246
119translational elongation (GO:0006414)2.99889078
120protein localization to mitochondrion (GO:0070585)2.99537961
121galactose catabolic process (GO:0019388)2.99142953
122deoxyribonucleotide catabolic process (GO:0009264)2.98747974
123purine ribonucleoside biosynthetic process (GO:0046129)2.97542978
124purine nucleoside biosynthetic process (GO:0042451)2.97542978
125tricarboxylic acid metabolic process (GO:0072350)2.96343849
126guanosine-containing compound biosynthetic process (GO:1901070)2.96227064
127establishment of integrated proviral latency (GO:0075713)2.95605694
128amino-acid betaine transport (GO:0015838)2.94910669
129carnitine transport (GO:0015879)2.94910669
130regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94818813
131mitochondrial fusion (GO:0008053)2.94808590
132regulation of sequestering of triglyceride (GO:0010889)2.94398313
133metallo-sulfur cluster assembly (GO:0031163)2.93776262
134iron-sulfur cluster assembly (GO:0016226)2.93776262
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93083749
136rRNA metabolic process (GO:0016072)2.93049354
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92851840
138cardiac myofibril assembly (GO:0055003)2.91936376
139actin-mediated cell contraction (GO:0070252)2.88321982
140glyoxylate metabolic process (GO:0046487)2.88215842
141regulation of cellular amino acid metabolic process (GO:0006521)2.88134048
142formation of translation preinitiation complex (GO:0001731)2.87844683
143regulation of skeletal muscle contraction (GO:0014819)2.86247927
144respiratory chain complex IV assembly (GO:0008535)2.81743815
145cardiac cell development (GO:0055006)2.80372076
146fatty acid catabolic process (GO:0009062)2.80055331
147negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79548177
148fatty acid oxidation (GO:0019395)2.78555746
149ketone body metabolic process (GO:1902224)2.78335933
150cytidine metabolic process (GO:0046087)2.77806169
151cytidine catabolic process (GO:0006216)2.77806169
152cytidine deamination (GO:0009972)2.77806169
153acetyl-CoA metabolic process (GO:0006084)2.76835514
154translation (GO:0006412)2.75343288
155* proton transport (GO:0015992)2.74241975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84138927
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.61820805
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.92932908
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45616806
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.23946930
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12072743
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.09909396
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04265587
9E2F7_22180533_ChIP-Seq_HELA_Human2.93762639
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.90818396
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.86765294
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86193205
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.66099071
14* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57894445
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43080141
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36949972
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31597821
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31108856
19* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25608181
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12759248
21DCP1A_22483619_ChIP-Seq_HELA_Human2.07061730
22ZNF263_19887448_ChIP-Seq_K562_Human2.02968173
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02530324
24STAT3_1855785_ChIP-Seq_MESCs_Mouse2.02097707
25XRN2_22483619_ChIP-Seq_HELA_Human2.01687488
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.96553283
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95536488
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.91574022
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85493798
30* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.84755571
31VDR_23849224_ChIP-Seq_CD4+_Human1.83140898
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77458627
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77416170
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76270090
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.71791992
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70820935
37GABP_19822575_ChIP-Seq_HepG2_Human1.70569864
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68248026
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.66321187
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64094827
41* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62993351
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59274244
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58773103
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58085420
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54577159
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54531036
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53550873
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53137209
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48859770
50* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46715140
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44270447
52TTF2_22483619_ChIP-Seq_HELA_Human1.43182030
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42527019
54FOXP3_21729870_ChIP-Seq_TREG_Human1.42438501
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39612618
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38363178
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26910435
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26068212
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25019907
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24689574
61* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24246146
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24098431
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.23111344
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22982310
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22186048
66* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22161028
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21717332
68AR_21909140_ChIP-Seq_LNCAP_Human1.21430895
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.20848146
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.19672035
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18320544
72MYC_18940864_ChIP-ChIP_HL60_Human1.17246731
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16925993
74* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15861521
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15746647
76* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15144021
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14349060
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14248238
79* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12029837
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09715166
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08295295
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07653524
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05939666
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05850287
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99988040
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99897665
87CIITA_25753668_ChIP-Seq_RAJI_Human0.98644788
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98638435
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.98578684
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94994567
91BCL6_27268052_Chip-Seq_Bcells_Human0.94848757
92GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94775990
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94352225
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.94200765
95ELK1_19687146_ChIP-ChIP_HELA_Human0.93883360
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93684331
97ATF3_27146783_Chip-Seq_COLON_Human0.93294307
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93191331
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.93032196
100* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92996985
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91835212
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91753106
103* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91665519
104* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91459461
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89371257
106KDM5A_27292631_Chip-Seq_BREAST_Human0.87707417
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87508358
108* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85844178
109* CTCF_26484167_Chip-Seq_Bcells_Mouse0.85101516
110* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84975982
111LXR_22158963_ChIP-Seq_LIVER_Mouse0.84949094
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82823002
113VDR_21846776_ChIP-Seq_THP-1_Human0.79797214
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78743563
115P68_20966046_ChIP-Seq_HELA_Human0.77801248
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77123291
117SA1_27219007_Chip-Seq_Bcells_Human0.77035240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.61112448
2MP0003806_abnormal_nucleotide_metabolis4.14950184
3MP0004084_abnormal_cardiac_muscle4.06036989
4MP0006036_abnormal_mitochondrial_physio3.86872041
5MP0002837_dystrophic_cardiac_calcinosis3.59428062
6MP0004215_abnormal_myocardial_fiber3.41803020
7MP0000751_myopathy3.39853489
8MP0005330_cardiomyopathy3.39188110
9MP0000749_muscle_degeneration3.21486626
10MP0004036_abnormal_muscle_relaxation2.93220419
11MP0006035_abnormal_mitochondrial_morpho2.66600135
12MP0005360_urolithiasis2.59635079
13MP0000750_abnormal_muscle_regeneration2.50822802
14MP0003221_abnormal_cardiomyocyte_apopto2.42449240
15MP0003186_abnormal_redox_activity2.31940471
16MP0004130_abnormal_muscle_cell2.29603453
17MP0004087_abnormal_muscle_fiber2.28481928
18MP0001529_abnormal_vocalization2.25264849
19MP0006292_abnormal_olfactory_placode2.21417390
20MP0002269_muscular_atrophy2.20815788
21MP0008775_abnormal_heart_ventricle2.18780173
22MP0002972_abnormal_cardiac_muscle2.17765678
23MP0008058_abnormal_DNA_repair2.16513985
24MP0003693_abnormal_embryo_hatching2.16502885
25MP0005085_abnormal_gallbladder_physiolo2.15298287
26MP0002139_abnormal_hepatobiliary_system2.07627028
27MP0002106_abnormal_muscle_physiology2.01366992
28MP0009840_abnormal_foam_cell1.99142890
29MP0005620_abnormal_muscle_contractility1.98863178
30MP0001544_abnormal_cardiovascular_syste1.98436485
31MP0005385_cardiovascular_system_phenoty1.98436485
32MP0004484_altered_response_of1.97543768
33MP0003137_abnormal_impulse_conducting1.95386923
34MP0002332_abnormal_exercise_endurance1.91803361
35MP0005332_abnormal_amino_acid1.87278335
36MP0004957_abnormal_blastocyst_morpholog1.82640496
37MP0005266_abnormal_metabolism1.78755924
38MP0000747_muscle_weakness1.76209378
39MP0010630_abnormal_cardiac_muscle1.70998361
40MP0004145_abnormal_muscle_electrophysio1.70931272
41MP0008789_abnormal_olfactory_epithelium1.66175657
42MP0000372_irregular_coat_pigmentation1.64876533
43MP0002163_abnormal_gland_morphology1.59289153
44MP0001188_hyperpigmentation1.53037376
45MP0005319_abnormal_enzyme/_coenzyme1.49835215
46MP0002234_abnormal_pharynx_morphology1.49100101
47MP0000759_abnormal_skeletal_muscle1.48459779
48MP0001905_abnormal_dopamine_level1.46861882
49MP0004043_abnormal_pH_regulation1.45297311
50MP0003567_abnormal_fetal_cardiomyocyte1.45150874
51MP0003195_calcinosis1.45069547
52MP0005369_muscle_phenotype1.43021767
53MP0002822_catalepsy1.42244826
54MP0004233_abnormal_muscle_weight1.35422731
55MP0005365_abnormal_bile_salt1.34557746
56MP0003828_pulmonary_edema1.33769715
57MP0006138_congestive_heart_failure1.33612472
58MP0000343_altered_response_to1.33400765
59MP0003786_premature_aging1.30994047
60MP0008875_abnormal_xenobiotic_pharmacok1.30820848
61MP0005666_abnormal_adipose_tissue1.26305263
62MP0005083_abnormal_biliary_tract1.26264943
63MP0008007_abnormal_cellular_replicative1.25057131
64MP0005670_abnormal_white_adipose1.23335252
65MP0005499_abnormal_olfactory_system1.22809569
66MP0005394_taste/olfaction_phenotype1.22809569
67MP0005584_abnormal_enzyme/coenzyme_acti1.22184975
68MP0002653_abnormal_ependyma_morphology1.19846088
69MP0005165_increased_susceptibility_to1.19368408
70MP0009643_abnormal_urine_homeostasis1.16731807
71MP0004858_abnormal_nervous_system1.14247379
72MP0005451_abnormal_body_composition1.13747855
73MP0000358_abnormal_cell_content/1.08011114
74MP0002127_abnormal_cardiovascular_syste1.06112780
75MP0001346_abnormal_lacrimal_gland1.05896635
76MP0009697_abnormal_copulation1.04475645
77MP0004142_abnormal_muscle_tone1.02557635
78MP0005645_abnormal_hypothalamus_physiol1.01974780
79MP0009046_muscle_twitch1.00249626
80MP0001853_heart_inflammation1.00240398
81MP0002638_abnormal_pupillary_reflex1.00210375
82MP0002160_abnormal_reproductive_system1.00030518
83MP0002938_white_spotting0.99215348
84MP0003718_maternal_effect0.94292186
85MP0000678_abnormal_parathyroid_gland0.93892540
86MP0000313_abnormal_cell_death0.93123708
87MP0003111_abnormal_nucleus_morphology0.92742923
88MP0000049_abnormal_middle_ear0.92529961
89MP0000566_synostosis0.92373992
90MP0003077_abnormal_cell_cycle0.91120185
91MP0004085_abnormal_heartbeat0.90301875
92MP0010030_abnormal_orbit_morphology0.90129078
93MP0005376_homeostasis/metabolism_phenot0.89517568
94MP0001764_abnormal_homeostasis0.88017791
95MP0006276_abnormal_autonomic_nervous0.84744409
96MP0001730_embryonic_growth_arrest0.84706640
97MP0005636_abnormal_mineral_homeostasis0.83371374
98MP0000350_abnormal_cell_proliferation0.83076118
99MP0005423_abnormal_somatic_nervous0.82840037
100MP0002971_abnormal_brown_adipose0.82412232
101MP0009379_abnormal_foot_pigmentation0.82192832
102MP0008932_abnormal_embryonic_tissue0.81521097
103MP0003878_abnormal_ear_physiology0.81129860
104MP0005377_hearing/vestibular/ear_phenot0.81129860
105MP0001666_abnormal_nutrient_absorption0.80476538
106MP0010329_abnormal_lipoprotein_level0.79655585
107MP0000609_abnormal_liver_physiology0.79649177
108MP0001881_abnormal_mammary_gland0.77477018
109MP0005646_abnormal_pituitary_gland0.76721691
110MP0003880_abnormal_central_pattern0.76675046
111MP0002118_abnormal_lipid_homeostasis0.76571647
112MP0004147_increased_porphyrin_level0.76422759
113MP0001756_abnormal_urination0.73011142
114MP0004510_myositis0.72811820
115MP0008872_abnormal_physiological_respon0.72735736
116MP0010094_abnormal_chromosome_stability0.72526663
117MP0004019_abnormal_vitamin_homeostasis0.72325221
118MP0003191_abnormal_cellular_cholesterol0.71839775
119MP0006072_abnormal_retinal_apoptosis0.71825948
120MP0004185_abnormal_adipocyte_glucose0.71824502
121MP0003656_abnormal_erythrocyte_physiolo0.69464080
122MP0001293_anophthalmia0.69022748
123MP0005535_abnormal_body_temperature0.68671012
124MP0000266_abnormal_heart_morphology0.67270959
125MP0003136_yellow_coat_color0.67039115
126MP0001984_abnormal_olfaction0.66681707
127MP0002210_abnormal_sex_determination0.66141369
128MP0000490_abnormal_crypts_of0.65761963
129MP0003011_delayed_dark_adaptation0.65550903
130MP0005379_endocrine/exocrine_gland_phen0.63874238
131MP0002272_abnormal_nervous_system0.63793564
132MP0003984_embryonic_growth_retardation0.62756429
133MP0002090_abnormal_vision0.62420023
134MP0003123_paternal_imprinting0.62324221
135MP0000230_abnormal_systemic_arterial0.62302558
136MP0001727_abnormal_embryo_implantation0.61280788
137MP0002088_abnormal_embryonic_growth/wei0.60938668
138MP0000598_abnormal_liver_morphology0.60105544
139MP0002736_abnormal_nociception_after0.59959431
140MP0000631_abnormal_neuroendocrine_gland0.59353762
141MP0004133_heterotaxia0.54998182
142MP0002078_abnormal_glucose_homeostasis0.53636451
143MP0001697_abnormal_embryo_size0.53374533
144MP0001672_abnormal_embryogenesis/_devel0.53103130
145MP0005380_embryogenesis_phenotype0.53103130
146MP0002080_prenatal_lethality0.51661549
147MP0003315_abnormal_perineum_morphology0.51271166

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.65471236
2Abnormal mitochondria in muscle tissue (HP:0008316)5.55625090
3Acute encephalopathy (HP:0006846)5.19803807
4Hepatic necrosis (HP:0002605)5.19459306
5Mitochondrial inheritance (HP:0001427)4.80428202
6Hepatocellular necrosis (HP:0001404)4.69400472
7Increased CSF lactate (HP:0002490)4.63148749
8Progressive macrocephaly (HP:0004481)4.60085402
9Cerebral edema (HP:0002181)4.46489001
10Myoglobinuria (HP:0002913)4.38562667
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.16516086
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.16516086
13Rhabdomyolysis (HP:0003201)4.11709120
14Sudden death (HP:0001699)3.99746439
15Exercise-induced muscle cramps (HP:0003710)3.99552310
16Lactic acidosis (HP:0003128)3.99115101
17Increased muscle lipid content (HP:0009058)3.96408551
18Reticulocytopenia (HP:0001896)3.93920986
19Macrocytic anemia (HP:0001972)3.90743627
20Dicarboxylic aciduria (HP:0003215)3.83279615
21Abnormality of dicarboxylic acid metabolism (HP:0010995)3.83279615
22Increased intramyocellular lipid droplets (HP:0012240)3.82355141
23Palpitations (HP:0001962)3.78739026
24Increased serum pyruvate (HP:0003542)3.68111969
25Abnormality of glycolysis (HP:0004366)3.68111969
26Exercise-induced myalgia (HP:0003738)3.66381134
27Respiratory failure (HP:0002878)3.61641239
28Exercise intolerance (HP:0003546)3.58100230
29Lipid accumulation in hepatocytes (HP:0006561)3.57711676
30Ventricular tachycardia (HP:0004756)3.56142076
31Increased serum lactate (HP:0002151)3.52211772
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.45435245
33Abnormality of alanine metabolism (HP:0010916)3.45435245
34Hyperalaninemia (HP:0003348)3.45435245
35Abnormality of fatty-acid metabolism (HP:0004359)3.45156235
36Hypoglycemic coma (HP:0001325)3.40441555
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.32144738
38Increased hepatocellular lipid droplets (HP:0006565)3.30519625
39Nausea (HP:0002018)3.26413019
40Lethargy (HP:0001254)3.24026918
41Calf muscle hypertrophy (HP:0008981)3.19477862
42Hyperglycinuria (HP:0003108)3.17803789
43Hyperammonemia (HP:0001987)3.17469249
44Generalized aminoaciduria (HP:0002909)3.10425168
45Multiple enchondromatosis (HP:0005701)3.10291881
46Ragged-red muscle fibers (HP:0003200)3.02500201
47Muscle hypertrophy of the lower extremities (HP:0008968)2.99063586
48Ketoacidosis (HP:0001993)2.88586132
49Microvesicular hepatic steatosis (HP:0001414)2.84569395
50Pallor (HP:0000980)2.82119329
51Lipoatrophy (HP:0100578)2.79499070
52Conjunctival hamartoma (HP:0100780)2.78232532
53Proximal tubulopathy (HP:0000114)2.76236154
54Myokymia (HP:0002411)2.75795972
55Muscle stiffness (HP:0003552)2.73676413
56CNS demyelination (HP:0007305)2.70661753
57Muscle fiber splitting (HP:0003555)2.69743104
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67148684
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63084629
60Ketosis (HP:0001946)2.58691788
61Abnormality of glycine metabolism (HP:0010895)2.57698072
62Abnormality of serine family amino acid metabolism (HP:0010894)2.57698072
63Atrial fibrillation (HP:0005110)2.50911345
64Supraventricular tachycardia (HP:0004755)2.48695431
65Dilated cardiomyopathy (HP:0001644)2.48503706
66Right ventricular cardiomyopathy (HP:0011663)2.47677833
67Vomiting (HP:0002013)2.46803721
68Abnormality of urine glucose concentration (HP:0011016)2.43464480
69Glycosuria (HP:0003076)2.43464480
70Primary atrial arrhythmia (HP:0001692)2.41447458
71Supraventricular arrhythmia (HP:0005115)2.40190691
72Metabolic acidosis (HP:0001942)2.39632581
73Bundle branch block (HP:0011710)2.38921630
74Optic disc pallor (HP:0000543)2.38152914
75Leukodystrophy (HP:0002415)2.38135482
76Gout (HP:0001997)2.37262500
77Syncope (HP:0001279)2.36716629
78Hyperglycinemia (HP:0002154)2.34983073
79Asymmetric septal hypertrophy (HP:0001670)2.34930596
80Methylmalonic aciduria (HP:0012120)2.34329386
81Muscle fiber inclusion bodies (HP:0100299)2.34257978
82Abnormality of the calf musculature (HP:0001430)2.34178241
83Pheochromocytoma (HP:0002666)2.34059099
84Neuroendocrine neoplasm (HP:0100634)2.33618238
85Ventricular arrhythmia (HP:0004308)2.31690422
86Neoplasm of the adrenal gland (HP:0100631)2.31050652
87Progressive muscle weakness (HP:0003323)2.30999653
88Ventricular fibrillation (HP:0001663)2.30613578
89Microretrognathia (HP:0000308)2.29980562
90Type I transferrin isoform profile (HP:0003642)2.29973947
91Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27604528
92Renal Fanconi syndrome (HP:0001994)2.24866064
93Emotional lability (HP:0000712)2.24502136
94Neoplasm of head and neck (HP:0012288)2.24017166
95Esophageal neoplasm (HP:0100751)2.24017166
96Abnormality of cells of the erythroid lineage (HP:0012130)2.23612008
97Respiratory difficulties (HP:0002880)2.22975445
98Myopathic facies (HP:0002058)2.22546228
99Abnormality of serum amino acid levels (HP:0003112)2.21515122
100Exertional dyspnea (HP:0002875)2.20962203
101Cerebral hypomyelination (HP:0006808)2.20156516
102Testicular atrophy (HP:0000029)2.18954963
103Abnormal number of erythroid precursors (HP:0012131)2.18211699
104Myotonia (HP:0002486)2.14619165
1053-Methylglutaconic aciduria (HP:0003535)2.13380952
106Aplastic anemia (HP:0001915)2.12851902
107Nemaline bodies (HP:0003798)2.12139188
108X-linked dominant inheritance (HP:0001423)2.12030264
109EMG: myopathic abnormalities (HP:0003458)2.11093633
110Abnormality of the anterior horn cell (HP:0006802)2.10616486
111Degeneration of anterior horn cells (HP:0002398)2.10616486
112Heart block (HP:0012722)2.10062065
113Reduced antithrombin III activity (HP:0001976)2.06180701
114Abnormality of renal resorption (HP:0011038)2.05721452
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05643031
116Areflexia of lower limbs (HP:0002522)2.02604101
117Gliosis (HP:0002171)2.00716158
118Subaortic stenosis (HP:0001682)1.99382206
119Hyperphosphaturia (HP:0003109)1.87295221
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81836880
121Abnormal protein N-linked glycosylation (HP:0012347)1.81836880
122Abnormal protein glycosylation (HP:0012346)1.81836880
123Abnormal glycosylation (HP:0012345)1.81836880
124Pancytopenia (HP:0001876)1.78484347
125Rimmed vacuoles (HP:0003805)1.76907357
126Abnormality of reticulocytes (HP:0004312)1.74417135
127Cerebral palsy (HP:0100021)1.68276462
128Calcaneovalgus deformity (HP:0001848)1.67083453
129Opisthotonus (HP:0002179)1.66646013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.99915854
2BCKDK4.38090212
3VRK24.19894659
4NME24.13729511
5OBSCN3.22980731
6PDK43.14164150
7PDK33.14164150
8BUB12.62471466
9CDK192.50030056
10MYLK2.40376772
11WEE12.39836698
12TTN2.39700364
13EIF2AK12.35277373
14NME12.32078865
15LMTK22.24409840
16MAP3K112.11154237
17PHKG12.05465499
18PHKG22.05465499
19PKN22.04402820
20PDK21.91034763
21KDR1.80082201
22PINK11.79181174
23ARAF1.70366444
24STK241.63568069
25STK161.56758420
26MAPKAPK31.53829778
27TESK11.51508147
28TESK21.48210419
29TRIB31.46849140
30LIMK11.46186154
31PIM21.30938028
32ILK1.30796390
33ZAK1.30157136
34MAP2K31.26430823
35PLK41.22813774
36CSNK1G31.21093375
37SCYL21.18152112
38EIF2AK31.16769045
39MAP2K71.10138007
40TTK1.10039962
41MAP3K121.08580030
42STK38L1.07436874
43ABL21.06216537
44CHEK20.95279733
45BRAF0.94089416
46NEK20.93948137
47CSNK1G20.92236197
48MAP3K50.90675862
49CCNB10.89810386
50MAP2K60.89675533
51RPS6KB20.87913338
52MAP4K20.86073104
53AURKA0.82266981
54ERN10.81925548
55MUSK0.81697780
56EPHA20.81367181
57CDK80.80206200
58RPS6KA50.78899523
59CSNK1A1L0.78705300
60DMPK0.77619098
61TAOK20.76740233
62PAK40.76526032
63CDK140.76482378
64DAPK30.76426904
65ACVR1B0.76160026
66CDK11A0.75742958
67CSNK1G10.75523037
68AURKB0.75251432
69ATR0.75131462
70BRSK20.74328961
71PLK10.69565125
72DYRK30.68424543
73PIK3CA0.67289969
74MINK10.67235823
75CDK150.65103288
76MAP3K30.63719730
77NEK90.63548044
78CAMK2G0.63416055
79LRRK20.62611549
80MAP3K80.62088142
81LATS20.62053777
82CDK180.59699481
83STK40.58878701
84FLT30.58091622
85RPS6KA40.57654632
86WNK40.57497299
87VRK10.57290031
88AKT20.57091179
89CAMK2D0.55477617
90PRKG20.54094490
91MAPK120.52890764
92EPHA40.51056450
93TRIM280.49987396
94PBK0.49078007
95MAPKAPK50.47936273
96TIE10.47628461
97BRSK10.47570853
98GRK70.46485566
99PAK10.46439078
100CDK40.45422427
101CDC70.44888072
102PLK30.39811727
103CHEK10.39017413
104CSNK1E0.37750808
105CSNK2A10.37391978
106CSNK1A10.36565455
107DYRK1B0.35906210
108GRK60.35043714
109CAMK2B0.33540235
110CAMK2A0.32181630
111TLK10.32042516
112KSR20.31842553
113CDK20.31779921
114PRKACA0.31528416
115RAF10.31395379
116IRAK30.30766807
117PRKAA10.30453435
118MARK10.30096810
119MAP2K40.29721942
120PRKCI0.28874937
121MAPK110.28715208
122MST1R0.28587926
123DYRK20.26706094
124PRKCD0.26470260
125TAOK10.26151328
126CSNK2A20.25463954
127NUAK10.25145047
128PRKCG0.24781408
129SRPK10.24731459
130CDK70.24561020
131MAP3K90.24245003
132PIK3CG0.23125428
133MAP2K20.21476791
134PRKACG0.19435443
135TBK10.19109114
136DAPK10.18401958
137MAP3K70.17189518

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.88709283
2* Oxidative phosphorylation_Homo sapiens_hsa001904.27409508
3Parkinsons disease_Homo sapiens_hsa050124.11813049
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.65857415
5Propanoate metabolism_Homo sapiens_hsa006402.91233964
6Huntingtons disease_Homo sapiens_hsa050162.86408539
7Alzheimers disease_Homo sapiens_hsa050102.77246988
8Proteasome_Homo sapiens_hsa030502.72138928
9Ribosome_Homo sapiens_hsa030102.70000165
10* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.67379088
11Carbon metabolism_Homo sapiens_hsa012002.64444504
12* Cardiac muscle contraction_Homo sapiens_hsa042602.62429789
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61625778
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44162495
15Fatty acid degradation_Homo sapiens_hsa000712.40787349
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13461811
17Pyruvate metabolism_Homo sapiens_hsa006202.05675347
18DNA replication_Homo sapiens_hsa030301.92304122
19Protein export_Homo sapiens_hsa030601.80337827
20Biosynthesis of amino acids_Homo sapiens_hsa012301.70906544
21Fatty acid metabolism_Homo sapiens_hsa012121.62307157
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55088028
23Butanoate metabolism_Homo sapiens_hsa006501.36657418
24Mismatch repair_Homo sapiens_hsa034301.35355149
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34178047
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32739464
27Pyrimidine metabolism_Homo sapiens_hsa002401.29070955
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.27132991
29RNA polymerase_Homo sapiens_hsa030201.25263672
30Folate biosynthesis_Homo sapiens_hsa007901.22190051
31Pentose phosphate pathway_Homo sapiens_hsa000301.19994291
32Peroxisome_Homo sapiens_hsa041461.17471067
33Sulfur relay system_Homo sapiens_hsa041221.17322060
34beta-Alanine metabolism_Homo sapiens_hsa004101.07353582
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06374035
36Sulfur metabolism_Homo sapiens_hsa009201.05197107
37Fructose and mannose metabolism_Homo sapiens_hsa000511.05071857
38Galactose metabolism_Homo sapiens_hsa000520.99032908
39Glutathione metabolism_Homo sapiens_hsa004800.98380957
40Tryptophan metabolism_Homo sapiens_hsa003800.98379628
41Arginine biosynthesis_Homo sapiens_hsa002200.96428722
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96205797
43PPAR signaling pathway_Homo sapiens_hsa033200.95987256
44Fatty acid elongation_Homo sapiens_hsa000620.94450940
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93468125
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90673073
47Fanconi anemia pathway_Homo sapiens_hsa034600.89813804
48Base excision repair_Homo sapiens_hsa034100.89371622
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.89367856
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87108668
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85737846
52Arginine and proline metabolism_Homo sapiens_hsa003300.85502674
53Starch and sucrose metabolism_Homo sapiens_hsa005000.84026100
54* Metabolic pathways_Homo sapiens_hsa011000.83798463
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79373611
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.77006235
57Spliceosome_Homo sapiens_hsa030400.70455068
58RNA transport_Homo sapiens_hsa030130.70420214
59One carbon pool by folate_Homo sapiens_hsa006700.70372847
60Nucleotide excision repair_Homo sapiens_hsa034200.69015947
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68855743
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68732615
63Fat digestion and absorption_Homo sapiens_hsa049750.68317512
64Phenylalanine metabolism_Homo sapiens_hsa003600.67579693
65Homologous recombination_Homo sapiens_hsa034400.67176685
66Asthma_Homo sapiens_hsa053100.66957578
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66483782
68Selenocompound metabolism_Homo sapiens_hsa004500.65775508
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65463151
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65302135
71Collecting duct acid secretion_Homo sapiens_hsa049660.63954744
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.59897034
73Purine metabolism_Homo sapiens_hsa002300.59470306
74Dilated cardiomyopathy_Homo sapiens_hsa054140.56440981
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56128907
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55022807
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46994465
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43613664
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42913606
80Tyrosine metabolism_Homo sapiens_hsa003500.42131806
81Vibrio cholerae infection_Homo sapiens_hsa051100.41079645
82Caffeine metabolism_Homo sapiens_hsa002320.40357835
83Non-homologous end-joining_Homo sapiens_hsa034500.38277518
84Basal transcription factors_Homo sapiens_hsa030220.37749527
85Chemical carcinogenesis_Homo sapiens_hsa052040.36900084
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34881994
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.34797588
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34051473
89Systemic lupus erythematosus_Homo sapiens_hsa053220.33846889
90Synaptic vesicle cycle_Homo sapiens_hsa047210.28481652
91RNA degradation_Homo sapiens_hsa030180.27587466
92Steroid biosynthesis_Homo sapiens_hsa001000.25489223
93mRNA surveillance pathway_Homo sapiens_hsa030150.24616054
94Glycerolipid metabolism_Homo sapiens_hsa005610.24262238
95Glucagon signaling pathway_Homo sapiens_hsa049220.23250131
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22906714
97Vitamin digestion and absorption_Homo sapiens_hsa049770.22856654
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.21148930
99Viral myocarditis_Homo sapiens_hsa054160.21074004
100Oocyte meiosis_Homo sapiens_hsa041140.19997182
101Bile secretion_Homo sapiens_hsa049760.19893325
102Insulin signaling pathway_Homo sapiens_hsa049100.19764697
103HIF-1 signaling pathway_Homo sapiens_hsa040660.19463233
104Legionellosis_Homo sapiens_hsa051340.18516513
105Cell cycle_Homo sapiens_hsa041100.17715138
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16758422
107p53 signaling pathway_Homo sapiens_hsa041150.14287739
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.13012821
109Histidine metabolism_Homo sapiens_hsa003400.12364293
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.11618915
111Fatty acid biosynthesis_Homo sapiens_hsa000610.11605517
112Arachidonic acid metabolism_Homo sapiens_hsa005900.10833161
113Regulation of autophagy_Homo sapiens_hsa041400.10539518
114Insulin resistance_Homo sapiens_hsa049310.09863330
115Allograft rejection_Homo sapiens_hsa053300.09696479
116N-Glycan biosynthesis_Homo sapiens_hsa005100.09243644
117Autoimmune thyroid disease_Homo sapiens_hsa053200.08956813
118AMPK signaling pathway_Homo sapiens_hsa041520.08893797
119Phototransduction_Homo sapiens_hsa047440.07324720
120Rheumatoid arthritis_Homo sapiens_hsa053230.06313860
121Retinol metabolism_Homo sapiens_hsa008300.05312501
122Epstein-Barr virus infection_Homo sapiens_hsa051690.01999540

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