COX5AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.57806349
2ribosomal small subunit biogenesis (GO:0042274)7.43628366
3translational termination (GO:0006415)7.16993410
4response to misfolded protein (GO:0051788)6.38547744
5translational elongation (GO:0006414)6.22804846
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.01983812
7protein targeting to ER (GO:0045047)5.88926725
8cotranslational protein targeting to membrane (GO:0006613)5.87999499
9viral life cycle (GO:0019058)5.79118613
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.62864802
11protein localization to endoplasmic reticulum (GO:0070972)5.46819701
12ribosomal small subunit assembly (GO:0000028)5.45831243
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.45431018
14ATP synthesis coupled proton transport (GO:0015986)5.45431018
15cellular protein complex disassembly (GO:0043624)5.41745898
16L-serine metabolic process (GO:0006563)5.36987127
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.26336071
18ubiquinone biosynthetic process (GO:0006744)5.12041143
19regulation of protein heterodimerization activity (GO:0043497)4.86817475
20DNA replication checkpoint (GO:0000076)4.84277906
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.79111708
22translational initiation (GO:0006413)4.61945794
23ubiquinone metabolic process (GO:0006743)4.52790636
24ribonucleoprotein complex disassembly (GO:0032988)4.49396796
25macromolecular complex disassembly (GO:0032984)4.46702401
26protein complex disassembly (GO:0043241)4.46496722
27protein neddylation (GO:0045116)4.45320071
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.44107330
29S-adenosylmethionine metabolic process (GO:0046500)4.34768600
30regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.25965602
31regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.25965602
32protein complex biogenesis (GO:0070271)4.20087795
33quinone biosynthetic process (GO:1901663)4.19313430
34mitochondrial respiratory chain complex I assembly (GO:0032981)4.18143362
35NADH dehydrogenase complex assembly (GO:0010257)4.18143362
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18143362
37translation (GO:0006412)4.13264803
38protein deneddylation (GO:0000338)4.11578745
39cellular response to arsenic-containing substance (GO:0071243)4.04490526
40organelle disassembly (GO:1903008)4.00282850
41positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.96938989
42mitochondrial respiratory chain complex assembly (GO:0033108)3.95995235
43protein targeting to membrane (GO:0006612)3.94473279
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.91183360
45regulation of translational elongation (GO:0006448)3.83568857
46deoxyribose phosphate biosynthetic process (GO:0046385)3.83125421
472-deoxyribonucleotide biosynthetic process (GO:0009265)3.83125421
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.67420573
49respiratory electron transport chain (GO:0022904)3.66455511
50electron transport chain (GO:0022900)3.60392484
51protein targeting to mitochondrion (GO:0006626)3.56430469
52ATP biosynthetic process (GO:0006754)3.53238055
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.47033360
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46628712
55pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.46431031
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.45218746
57cerebral cortex neuron differentiation (GO:0021895)3.45167365
58cellular component biogenesis (GO:0044085)3.45148838
59ribonucleoprotein complex biogenesis (GO:0022613)3.45054472
60membrane repolarization during action potential (GO:0086011)3.43203699
61protein heterotetramerization (GO:0051290)3.37776696
62pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.31972198
63positive regulation of skeletal muscle tissue development (GO:0048643)3.30404357
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29558043
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29558043
66hypothalamus development (GO:0021854)3.27782506
67GTP biosynthetic process (GO:0006183)3.25699128
68ribonucleoside triphosphate biosynthetic process (GO:0009201)3.25318706
69respiratory system process (GO:0003016)3.24925977
70mRNA catabolic process (GO:0006402)3.24360005
71establishment of protein localization to mitochondrion (GO:0072655)3.22087470
72nonmotile primary cilium assembly (GO:0035058)3.17100535
73guanosine-containing compound biosynthetic process (GO:1901070)3.15945907
74regulation of neurotransmitter uptake (GO:0051580)3.15195616
75pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12851825
76serine family amino acid biosynthetic process (GO:0009070)3.11984760
77ear development (GO:0043583)3.10951435
78protein localization to mitochondrion (GO:0070585)3.10401761
79misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.09518920
80rRNA processing (GO:0006364)3.07938330
81UTP biosynthetic process (GO:0006228)3.06960695
82L-methionine biosynthetic process (GO:0071265)3.06264403
83amino acid salvage (GO:0043102)3.06264403
84L-methionine salvage (GO:0071267)3.06264403
85face development (GO:0060324)3.05624480
86ribosomal large subunit biogenesis (GO:0042273)3.03474636
87positive regulation of hair follicle development (GO:0051798)3.02242170
88positive regulation of hair cycle (GO:0042635)3.02242170
89nucleoside triphosphate biosynthetic process (GO:0009142)3.01378826
90mitochondrion transport along microtubule (GO:0047497)3.01000466
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01000466
92polarized epithelial cell differentiation (GO:0030859)2.98570901
93rRNA metabolic process (GO:0016072)2.96430536
94cytochrome complex assembly (GO:0017004)2.93316970
95RNA catabolic process (GO:0006401)2.92714328
96establishment of monopolar cell polarity (GO:0061162)2.92273560
97establishment or maintenance of monopolar cell polarity (GO:0061339)2.92273560
98respiratory chain complex IV assembly (GO:0008535)2.92178167
99maturation of SSU-rRNA (GO:0030490)13.5967565
100chaperone-mediated protein transport (GO:0072321)10.6059575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.87291522
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.65768103
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.64363998
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.40979548
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.20104126
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07183578
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04568974
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96596741
9SRY_22984422_ChIP-ChIP_TESTIS_Rat2.92762840
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.88099217
11XRN2_22483619_ChIP-Seq_HELA_Human2.63549960
12YY1_21170310_ChIP-Seq_MESCs_Mouse2.48177648
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44906395
14ZNF263_19887448_ChIP-Seq_K562_Human2.41934779
15TTF2_22483619_ChIP-Seq_HELA_Human2.37442214
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29660668
17POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.27345625
18VDR_23849224_ChIP-Seq_CD4+_Human2.23275683
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18280119
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06111157
21FOXP3_21729870_ChIP-Seq_TREG_Human1.96955750
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.94315249
23KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.91036662
24RNF2_27304074_Chip-Seq_NSC_Mouse1.89647900
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89492926
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.86530665
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78375617
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.77097502
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76358882
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74031049
31GABP_19822575_ChIP-Seq_HepG2_Human1.73491173
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.72693258
33DCP1A_22483619_ChIP-Seq_HELA_Human1.70583324
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69476777
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.67595193
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62421412
37MYC_18940864_ChIP-ChIP_HL60_Human1.61474256
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60287470
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60196629
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58989384
41KDM5A_27292631_Chip-Seq_BREAST_Human1.57400345
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.56874414
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50297583
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47448628
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45922237
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42439128
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40657439
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39637864
49CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39210667
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37096405
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35768890
52TP53_22573176_ChIP-Seq_HFKS_Human1.25334622
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24339601
54EWS_26573619_Chip-Seq_HEK293_Human1.21924714
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19871852
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19871852
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17435229
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.17001595
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16779722
60FOXP1_21924763_ChIP-Seq_HESCs_Human1.16065943
61HTT_18923047_ChIP-ChIP_STHdh_Human1.15272052
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.14973893
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12892209
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11951733
65ZNF274_21170338_ChIP-Seq_K562_Hela1.11070003
66EZH2_22144423_ChIP-Seq_EOC_Human1.11063692
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10613943
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10327228
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09938058
70CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09025015
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08966726
72NCOR_22424771_ChIP-Seq_293T_Human1.05556939
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04002973
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02589600
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.00402172
76CTCF_26484167_Chip-Seq_Bcells_Mouse0.99956453
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99439998
78ERA_21632823_ChIP-Seq_H3396_Human0.98007666
79TP63_19390658_ChIP-ChIP_HaCaT_Human0.97910641
80CIITA_25753668_ChIP-Seq_RAJI_Human0.97678060
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97030721
82NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94897603
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94402300
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92826822
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.91937443
86REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89767705
87TAF2_19829295_ChIP-Seq_ESCs_Human0.89246700
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88439467
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88439467
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88439467
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87970196
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.86164623
93P68_20966046_ChIP-Seq_HELA_Human0.85837166
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.85716307
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85406320
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84929803
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84749737
98SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84528416
99SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.83153613
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82446407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology4.66865885
2MP0009379_abnormal_foot_pigmentation3.94132296
3MP0001529_abnormal_vocalization3.33125299
4MP0006292_abnormal_olfactory_placode3.24676491
5MP0005379_endocrine/exocrine_gland_phen3.14391596
6MP0004858_abnormal_nervous_system2.98215173
7MP0004885_abnormal_endolymph2.93241178
8MP0003136_yellow_coat_color2.31944378
9MP0000631_abnormal_neuroendocrine_gland2.31225257
10MP0010030_abnormal_orbit_morphology2.26874138
11MP0009053_abnormal_anal_canal2.22404952
12MP0000537_abnormal_urethra_morphology2.22359056
13MP0000566_synostosis2.18762281
14MP0004145_abnormal_muscle_electrophysio2.18125922
15MP0005646_abnormal_pituitary_gland2.16958239
16MP0008260_abnormal_autophagy2.05964606
17MP0003941_abnormal_skin_development2.02273340
18MP0005423_abnormal_somatic_nervous1.99799645
19MP0001348_abnormal_lacrimal_gland1.99037283
20MP0003123_paternal_imprinting1.96433521
21MP0006035_abnormal_mitochondrial_morpho1.84091108
22MP0006036_abnormal_mitochondrial_physio1.83905386
23MP0005083_abnormal_biliary_tract1.81390074
24MP0002234_abnormal_pharynx_morphology1.80604525
25MP0000049_abnormal_middle_ear1.72752997
26MP0002160_abnormal_reproductive_system1.63020339
27MP0003315_abnormal_perineum_morphology1.62017653
28MP0000778_abnormal_nervous_system1.61809370
29MP0002277_abnormal_respiratory_mucosa1.58103365
30MP0000678_abnormal_parathyroid_gland1.51757365
31MP0004142_abnormal_muscle_tone1.51689879
32MP0002653_abnormal_ependyma_morphology1.49040946
33MP0003567_abnormal_fetal_cardiomyocyte1.43598801
34MP0003786_premature_aging1.43276844
35MP0000428_abnormal_craniofacial_morphol1.41079002
36MP0005187_abnormal_penis_morphology1.39993558
37MP0001905_abnormal_dopamine_level1.37254319
38MP0003879_abnormal_hair_cell1.36702348
39MP0002938_white_spotting1.36607837
40MP0003122_maternal_imprinting1.35639183
41MP0001293_anophthalmia1.34086374
42MP0003646_muscle_fatigue1.32424993
43MP0001299_abnormal_eye_distance/1.31684251
44MP0001346_abnormal_lacrimal_gland1.27198836
45MP0002638_abnormal_pupillary_reflex1.25670660
46MP0005360_urolithiasis1.21444454
47MP0003942_abnormal_urinary_system1.20170793
48MP0004147_increased_porphyrin_level1.16255404
49MP0009046_muscle_twitch1.15885797
50MP0003186_abnormal_redox_activity1.15455945
51MP0002249_abnormal_larynx_morphology1.15101128
52MP0005386_behavior/neurological_phenoty1.14198682
53MP0004924_abnormal_behavior1.14198682
54MP0002095_abnormal_skin_pigmentation1.14099174
55MP0002837_dystrophic_cardiac_calcinosis1.11548843
56MP0009250_abnormal_appendicular_skeleto1.09522715
57MP0005389_reproductive_system_phenotype1.06868938
58MP0006276_abnormal_autonomic_nervous1.06755148
59MP0003283_abnormal_digestive_organ1.04896236
60MP0000647_abnormal_sebaceous_gland1.03727414
61MP0000026_abnormal_inner_ear1.03376468
62MP0003119_abnormal_digestive_system1.02231895
63MP0003221_abnormal_cardiomyocyte_apopto0.99892984
64MP0009745_abnormal_behavioral_response0.92561619
65MP0005084_abnormal_gallbladder_morpholo0.91274611
66MP0008932_abnormal_embryonic_tissue0.90935384
67MP0001963_abnormal_hearing_physiology0.90851507
68MP0002177_abnormal_outer_ear0.89739009
69MP0005551_abnormal_eye_electrophysiolog0.87816190
70MP0002282_abnormal_trachea_morphology0.87456848
71MP0008789_abnormal_olfactory_epithelium0.87342778
72MP0002210_abnormal_sex_determination0.86488228
73MP0001286_abnormal_eye_development0.86294393
74MP0002233_abnormal_nose_morphology0.85528866
75MP0003938_abnormal_ear_development0.85393325
76MP0002116_abnormal_craniofacial_bone0.83638544
77MP0003693_abnormal_embryo_hatching0.83291307
78MP0000955_abnormal_spinal_cord0.79809370
79MP0002932_abnormal_joint_morphology0.79139519
80MP0003011_delayed_dark_adaptation0.78598031
81MP0002064_seizures0.78552864
82MP0002736_abnormal_nociception_after0.75675468
83MP0002557_abnormal_social/conspecific_i0.75359159
84MP0008058_abnormal_DNA_repair0.74421448
85MP0003806_abnormal_nucleotide_metabolis0.74298628
86MP0008877_abnormal_DNA_methylation0.72694544
87MP0002733_abnormal_thermal_nociception0.72558858
88MP0009780_abnormal_chondrocyte_physiolo0.71638603
89MP0003385_abnormal_body_wall0.71066767
90MP0003755_abnormal_palate_morphology0.69683619
91MP0001340_abnormal_eyelid_morphology0.69239622
92MP0003937_abnormal_limbs/digits/tail_de0.68122966
93MP0000343_altered_response_to0.66915035
94MP0000653_abnormal_sex_gland0.66529156
95MP0002132_abnormal_respiratory_system0.65726580
96MP0009764_decreased_sensitivity_to0.64344617
97MP0004130_abnormal_muscle_cell0.62341642
98MP0002752_abnormal_somatic_nervous0.62305705
99MP0003121_genomic_imprinting0.60335455
100MP0000516_abnormal_urinary_system0.59744222

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.18539779
2Macrocytic anemia (HP:0001972)4.82528903
33-Methylglutaconic aciduria (HP:0003535)4.53499928
4Reticulocytopenia (HP:0001896)4.50328485
5Lipid accumulation in hepatocytes (HP:0006561)4.28905974
6Acute necrotizing encephalopathy (HP:0006965)4.16517419
7Abnormal mitochondria in muscle tissue (HP:0008316)3.75858203
8Increased hepatocellular lipid droplets (HP:0006565)3.67600827
9Increased serum lactate (HP:0002151)3.65828719
10Mitochondrial inheritance (HP:0001427)3.62889281
11Increased muscle lipid content (HP:0009058)3.58494178
12Acute encephalopathy (HP:0006846)3.51328624
13Increased intramyocellular lipid droplets (HP:0012240)3.49805667
14Abnormality of lateral ventricle (HP:0030047)3.43677544
15Increased CSF lactate (HP:0002490)3.31404285
16Maternal diabetes (HP:0009800)3.31289698
17Progressive macrocephaly (HP:0004481)3.31185663
18Renal Fanconi syndrome (HP:0001994)3.27227954
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22034117
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22034117
21Medial flaring of the eyebrow (HP:0010747)3.15337931
22Coronal craniosynostosis (HP:0004440)3.11925822
23Gait imbalance (HP:0002141)3.08570346
24Absent septum pellucidum (HP:0001331)2.99281973
25Respiratory difficulties (HP:0002880)2.95777567
26Congenital primary aphakia (HP:0007707)2.87280568
27Pallor (HP:0000980)2.85144953
28Abnormality of cells of the erythroid lineage (HP:0012130)2.81344160
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79299465
30Exertional dyspnea (HP:0002875)2.76824480
31Vaginal atresia (HP:0000148)2.76578406
32Genital tract atresia (HP:0001827)2.75605303
33Increased serum pyruvate (HP:0003542)2.68161471
34Abnormality of alanine metabolism (HP:0010916)2.65609475
35Hyperalaninemia (HP:0003348)2.65609475
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65609475
37Lactic acidosis (HP:0003128)2.59672913
38Poor coordination (HP:0002370)2.53618251
39Hepatocellular necrosis (HP:0001404)2.52661476
40Abnormality of cochlea (HP:0000375)2.52433744
41Abnormal number of erythroid precursors (HP:0012131)2.50648093
42Turricephaly (HP:0000262)2.50520560
43Optic nerve hypoplasia (HP:0000609)2.49896052
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48269286
45Abnormality of the septum pellucidum (HP:0007375)2.46209374
46Delayed CNS myelination (HP:0002188)2.43010725
47Nephrogenic diabetes insipidus (HP:0009806)2.41738362
48Rib fusion (HP:0000902)2.40755170
49Status epilepticus (HP:0002133)2.39759921
50Congenital stationary night blindness (HP:0007642)2.35107162
51Poor suck (HP:0002033)2.32280222
52True hermaphroditism (HP:0010459)2.30944673
53Pancreatic fibrosis (HP:0100732)2.30819159
54Myokymia (HP:0002411)2.27606231
55Cleft eyelid (HP:0000625)2.26425613
56Progressive microcephaly (HP:0000253)2.22785331
57Adrenal hypoplasia (HP:0000835)2.17261379
58Cerebral edema (HP:0002181)2.17097818
59Hepatic necrosis (HP:0002605)2.16943266
60Abnormality of the parietal bone (HP:0002696)2.15787373
61Exercise intolerance (HP:0003546)2.15056193
62Pancreatic cysts (HP:0001737)2.14231090
63Absent thumb (HP:0009777)2.12003346
64Cortical visual impairment (HP:0100704)2.11939007
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09879247
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09310242
67Birth length less than 3rd percentile (HP:0003561)2.09131335
68Sensory axonal neuropathy (HP:0003390)2.07959123
69Abnormality of renal resorption (HP:0011038)2.06929140
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.03615895
71Absent/shortened dynein arms (HP:0200106)2.03615895
72Abnormal rod and cone electroretinograms (HP:0008323)2.01998950
73Absent eyebrow (HP:0002223)1.98115524
74Respiratory failure (HP:0002878)1.96001622
75Long foot (HP:0001833)1.95437533
76Wide intermamillary distance (HP:0006610)1.92169253
77Bilateral microphthalmos (HP:0007633)1.89637231
78Polycystic ovaries (HP:0000147)1.86251477
79Abnormality of the phalanges of the hallux (HP:0010057)1.86181660
80Leukodystrophy (HP:0002415)1.86093762
81Myotonia (HP:0002486)1.85517997
82Specific learning disability (HP:0001328)1.85085771
83Morphological abnormality of the inner ear (HP:0011390)1.84768053
84Hyperglycinemia (HP:0002154)1.84192556
85Abnormality of glycolysis (HP:0004366)1.82916611
86Triphalangeal thumb (HP:0001199)1.78710256
87Hyperventilation (HP:0002883)1.73893217
88Partial duplication of the phalanx of hand (HP:0009999)1.73677511
89Abnormal respiratory motile cilium physiology (HP:0012261)1.71905085
90Broad hallux (HP:0010055)1.71092361
91Anophthalmia (HP:0000528)1.70705152
92Hyperphosphaturia (HP:0003109)1.70627322
93Lethargy (HP:0001254)1.67202171
94Growth hormone deficiency (HP:0000824)1.66428966
95Overriding aorta (HP:0002623)1.65335879
96Abnormal ciliary motility (HP:0012262)1.63486730
97Abnormality of the middle phalanges of the toes (HP:0010183)1.63370141
98Glycosuria (HP:0003076)1.62826624
99Abnormality of urine glucose concentration (HP:0011016)1.62826624
100Morphological abnormality of the middle ear (HP:0008609)1.61708731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.94941265
2NME24.33246607
3EPHB24.08635179
4PLK23.65152111
5PRKD33.16945296
6STK32.85892681
7WNK42.76264152
8GRK12.48730574
9PIK3CA2.28908595
10PAK62.16286862
11BUB11.96926095
12PASK1.66497819
13ERBB21.60381010
14BMPR1B1.58968564
15RPS6KA41.54463201
16DYRK21.53321820
17PIM21.51710765
18PDK21.47733338
19TNIK1.45983798
20PLK31.41595003
21ADRBK21.35165891
22PNCK1.30429789
23CAMK1G1.24832710
24LATS11.20722132
25MAPK131.18116149
26CCNB11.17899116
27DMPK1.15876131
28RPS6KA51.15390720
29CSNK2A21.05633013
30LRRK21.03133991
31CSNK1A10.98279719
32ABL20.98077852
33NEK10.97431872
34PAK20.96533379
35ZAK0.95673541
36TYK20.92797729
37CAMKK20.92522861
38TRIM280.92009653
39MAP2K60.89593682
40DYRK30.85666402
41MARK10.83661061
42CDK140.82515503
43CSNK2A10.82322118
44AURKB0.80006296
45MOS0.78890900
46CAMK1D0.76496338
47CAMK2A0.76444253
48TGFBR10.74278177
49CAMK10.73857485
50ATR0.73548636
51PRKCQ0.72495641
52PINK10.69813198
53MARK30.69370543
54IKBKB0.68156421
55EIF2AK20.65734079
56KIT0.65694530
57SGK10.65021419
58PRKG10.64158148
59PRKCI0.62889225
60INSRR0.62206166
61CSNK1G20.62201996
62PRKG20.61347152
63PRKCZ0.61158834
64WNK10.60682233
65TLK10.58211796
66CSNK1G30.57739280
67OBSCN0.56862223
68PLK10.53319237
69NUAK10.52999403
70PRKCG0.52980697
71TEC0.52812506
72PRKACA0.51721568
73MAPK150.51102873
74PAK10.50883035
75PAK30.50807132
76CHEK20.49880090
77IRAK40.49552487
78AKT10.48081530
79TXK0.48049975
80CAMKK10.47573275
81PHKG20.46527127
82PHKG10.46527127
83RPS6KA20.46248781
84PRKCA0.46185803
85DAPK20.45700558
86STK110.45509603
87RPS6KA60.44743057
88IRAK30.44480925
89UHMK10.44463624
90PRKCD0.42951458
91PLK40.42296293
92CSNK1E0.40798078
93IKBKE0.39010444
94FRK0.36312445
95PDGFRB0.36017900
96MINK10.35925990
97RPS6KA30.35161031
98PRKCE0.34868206
99PRKACB0.34468607
100PRKDC0.33703749

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.54032150
2Oxidative phosphorylation_Homo sapiens_hsa001904.17902257
3Parkinsons disease_Homo sapiens_hsa050123.55839733
4Nitrogen metabolism_Homo sapiens_hsa009103.32439304
5Sulfur relay system_Homo sapiens_hsa041222.84816270
6Huntingtons disease_Homo sapiens_hsa050162.68394578
7One carbon pool by folate_Homo sapiens_hsa006702.59919433
8RNA polymerase_Homo sapiens_hsa030202.57842277
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42993150
10Alzheimers disease_Homo sapiens_hsa050102.37028352
11Cardiac muscle contraction_Homo sapiens_hsa042602.19580763
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02251134
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66393333
14Pyrimidine metabolism_Homo sapiens_hsa002401.65819631
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.65194682
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52043412
17Proteasome_Homo sapiens_hsa030501.49234593
18Protein export_Homo sapiens_hsa030601.43952216
19Pyruvate metabolism_Homo sapiens_hsa006201.40456839
20DNA replication_Homo sapiens_hsa030301.35911694
21Caffeine metabolism_Homo sapiens_hsa002321.33849819
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31874395
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31213918
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25839049
25Fat digestion and absorption_Homo sapiens_hsa049751.20516607
26Dorso-ventral axis formation_Homo sapiens_hsa043201.18876534
27Homologous recombination_Homo sapiens_hsa034401.18520134
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17709710
29Linoleic acid metabolism_Homo sapiens_hsa005911.16623714
30Fanconi anemia pathway_Homo sapiens_hsa034601.15530877
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15117829
32Steroid biosynthesis_Homo sapiens_hsa001001.15066129
33Phototransduction_Homo sapiens_hsa047441.13873214
34Sulfur metabolism_Homo sapiens_hsa009201.10653092
35Tryptophan metabolism_Homo sapiens_hsa003801.03768999
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02299995
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.00762482
38Fatty acid degradation_Homo sapiens_hsa000710.96774925
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94121929
40RNA degradation_Homo sapiens_hsa030180.89325858
41Retinol metabolism_Homo sapiens_hsa008300.89135737
42Nucleotide excision repair_Homo sapiens_hsa034200.88466960
43Collecting duct acid secretion_Homo sapiens_hsa049660.87015900
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84269925
45Basal transcription factors_Homo sapiens_hsa030220.83462011
46Arginine and proline metabolism_Homo sapiens_hsa003300.82845112
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82426853
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80451909
49Spliceosome_Homo sapiens_hsa030400.79363084
50Metabolic pathways_Homo sapiens_hsa011000.76440739
51Basal cell carcinoma_Homo sapiens_hsa052170.74976787
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.74903011
53Purine metabolism_Homo sapiens_hsa002300.71640395
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70261156
55Arachidonic acid metabolism_Homo sapiens_hsa005900.67740575
56Glycerolipid metabolism_Homo sapiens_hsa005610.66147931
57Ether lipid metabolism_Homo sapiens_hsa005650.64825387
58Lysine degradation_Homo sapiens_hsa003100.63183903
59RNA transport_Homo sapiens_hsa030130.63035450
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62743111
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.61211771
62Selenocompound metabolism_Homo sapiens_hsa004500.58439166
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55910992
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54455960
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52514304
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47561594
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47441323
68Chemical carcinogenesis_Homo sapiens_hsa052040.46480259
69Vitamin digestion and absorption_Homo sapiens_hsa049770.44820626
70Olfactory transduction_Homo sapiens_hsa047400.43044284
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42968151
72Peroxisome_Homo sapiens_hsa041460.42437313
73Nicotine addiction_Homo sapiens_hsa050330.39087535
74Cell cycle_Homo sapiens_hsa041100.38577741
75Asthma_Homo sapiens_hsa053100.38507879
76Tyrosine metabolism_Homo sapiens_hsa003500.38399017
77Protein digestion and absorption_Homo sapiens_hsa049740.38365421
78Base excision repair_Homo sapiens_hsa034100.38296400
79Mismatch repair_Homo sapiens_hsa034300.37217877
80Arginine biosynthesis_Homo sapiens_hsa002200.36589531
81Folate biosynthesis_Homo sapiens_hsa007900.35750427
82beta-Alanine metabolism_Homo sapiens_hsa004100.34805102
83Mineral absorption_Homo sapiens_hsa049780.33108885
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32322996
85Biosynthesis of amino acids_Homo sapiens_hsa012300.32310605
86Hedgehog signaling pathway_Homo sapiens_hsa043400.31581904
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31361634
88Non-homologous end-joining_Homo sapiens_hsa034500.30983599
89Oocyte meiosis_Homo sapiens_hsa041140.29786701
90Phenylalanine metabolism_Homo sapiens_hsa003600.29022380
91Pancreatic secretion_Homo sapiens_hsa049720.28748053
92Regulation of autophagy_Homo sapiens_hsa041400.26315542
93Gastric acid secretion_Homo sapiens_hsa049710.25317833
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23689930
95Propanoate metabolism_Homo sapiens_hsa006400.19962317
96Butanoate metabolism_Homo sapiens_hsa006500.19924137
97ABC transporters_Homo sapiens_hsa020100.19606321
98Insulin secretion_Homo sapiens_hsa049110.17564559
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16706525
100Hippo signaling pathway_Homo sapiens_hsa043900.16159158

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