Rank | Gene Set | Z-score |
---|---|---|
1 | ATP synthesis coupled proton transport (GO:0015986) | 9.52740232 |
2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 9.52740232 |
3 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 8.68561323 |
4 | * respiratory electron transport chain (GO:0022904) | 8.44503696 |
5 | * electron transport chain (GO:0022900) | 8.21400660 |
6 | oxidative phosphorylation (GO:0006119) | 7.08843101 |
7 | tricarboxylic acid cycle (GO:0006099) | 5.92490053 |
8 | ATP biosynthetic process (GO:0006754) | 5.69237967 |
9 | viral transcription (GO:0019083) | 5.22365179 |
10 | translational termination (GO:0006415) | 5.01419123 |
11 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.99033811 |
12 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.92662494 |
13 | inner mitochondrial membrane organization (GO:0007007) | 4.75714847 |
14 | ribosomal small subunit assembly (GO:0000028) | 4.72007797 |
15 | protein complex biogenesis (GO:0070271) | 4.69213275 |
16 | sarcomere organization (GO:0045214) | 4.65127410 |
17 | ribosomal small subunit biogenesis (GO:0042274) | 4.60110691 |
18 | * hydrogen ion transmembrane transport (GO:1902600) | 4.53653734 |
19 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 4.51216746 |
20 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.50628617 |
21 | translational elongation (GO:0006414) | 4.48046625 |
22 | NADH metabolic process (GO:0006734) | 4.47769635 |
23 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.46859258 |
24 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.46859258 |
25 | NADH dehydrogenase complex assembly (GO:0010257) | 4.46859258 |
26 | regulation of mitochondrial translation (GO:0070129) | 4.36755320 |
27 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.30925475 |
28 | protein targeting to ER (GO:0045047) | 4.28595844 |
29 | proteasome assembly (GO:0043248) | 4.27237125 |
30 | protein neddylation (GO:0045116) | 4.24502565 |
31 | cotranslational protein targeting to membrane (GO:0006613) | 4.23475460 |
32 | ubiquinone biosynthetic process (GO:0006744) | 4.17752970 |
33 | quinone biosynthetic process (GO:1901663) | 4.17752970 |
34 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.12207512 |
35 | aerobic respiration (GO:0009060) | 4.08548508 |
36 | termination of RNA polymerase III transcription (GO:0006386) | 4.07737344 |
37 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.07737344 |
38 | protein localization to endoplasmic reticulum (GO:0070972) | 4.04773089 |
39 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.97483116 |
40 | cellular protein complex disassembly (GO:0043624) | 3.94643706 |
41 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.91755727 |
42 | viral life cycle (GO:0019058) | 3.91471856 |
43 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.90662077 |
44 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.90662077 |
45 | DNA deamination (GO:0045006) | 3.90283137 |
46 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 3.89432073 |
47 | protein targeting to membrane (GO:0006612) | 3.80754415 |
48 | * proton transport (GO:0015992) | 3.79359948 |
49 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 3.76835734 |
50 | succinate metabolic process (GO:0006105) | 3.75953117 |
51 | mitochondrial transport (GO:0006839) | 3.74917353 |
52 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.73756267 |
53 | * hydrogen transport (GO:0006818) | 3.73147391 |
54 | actin-myosin filament sliding (GO:0033275) | 3.71489167 |
55 | muscle filament sliding (GO:0030049) | 3.71489167 |
56 | cardiac myofibril assembly (GO:0055003) | 3.70586401 |
57 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.68844548 |
58 | cellular component biogenesis (GO:0044085) | 3.65920306 |
59 | cardiac muscle contraction (GO:0060048) | 3.65173063 |
60 | heart process (GO:0003015) | 3.60858117 |
61 | heart contraction (GO:0060047) | 3.60858117 |
62 | pseudouridine synthesis (GO:0001522) | 3.59409155 |
63 | regulation of oxidative phosphorylation (GO:0002082) | 3.59116142 |
64 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.59021520 |
65 | regulation of cofactor metabolic process (GO:0051193) | 3.58572521 |
66 | regulation of coenzyme metabolic process (GO:0051196) | 3.58572521 |
67 | translational initiation (GO:0006413) | 3.57917644 |
68 | ubiquinone metabolic process (GO:0006743) | 3.56552068 |
69 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.50738253 |
70 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.49548668 |
71 | cellular ketone body metabolic process (GO:0046950) | 3.48301536 |
72 | respiratory chain complex IV assembly (GO:0008535) | 3.47352699 |
73 | regulation of cellular respiration (GO:0043457) | 3.44425801 |
74 | heme biosynthetic process (GO:0006783) | 3.44090133 |
75 | chaperone-mediated protein transport (GO:0072321) | 3.43787963 |
76 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.42926824 |
77 | lysine catabolic process (GO:0006554) | 3.40948974 |
78 | lysine metabolic process (GO:0006553) | 3.40948974 |
79 | ribosomal large subunit biogenesis (GO:0042273) | 3.39944458 |
80 | protein-cofactor linkage (GO:0018065) | 3.39649580 |
81 | translation (GO:0006412) | 3.39408288 |
82 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.38763185 |
83 | regulation of relaxation of muscle (GO:1901077) | 3.37775697 |
84 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.35582019 |
85 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.34711444 |
86 | * generation of precursor metabolites and energy (GO:0006091) | 3.33828243 |
87 | myofibril assembly (GO:0030239) | 3.32736967 |
88 | regulation of cell communication by electrical coupling (GO:0010649) | 3.31927156 |
89 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.30548409 |
90 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.29403490 |
91 | rRNA modification (GO:0000154) | 3.27956057 |
92 | cytochrome complex assembly (GO:0017004) | 3.27563588 |
93 | protein targeting to mitochondrion (GO:0006626) | 3.27553085 |
94 | protein complex disassembly (GO:0043241) | 3.26887692 |
95 | ribonucleoside monophosphate biosynthetic process (GO:0009156) | 3.24281260 |
96 | cellular respiration (GO:0045333) | 3.24126687 |
97 | GTP biosynthetic process (GO:0006183) | 3.23722886 |
98 | maturation of SSU-rRNA (GO:0030490) | 3.23549938 |
99 | carnitine shuttle (GO:0006853) | 3.22049048 |
100 | intracellular protein transmembrane import (GO:0044743) | 3.21838991 |
101 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.21617360 |
102 | establishment of protein localization to mitochondrion (GO:0072655) | 3.21454507 |
103 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.20835084 |
104 | negative regulation of ligase activity (GO:0051352) | 3.20835084 |
105 | purine nucleoside biosynthetic process (GO:0042451) | 3.20156855 |
106 | purine ribonucleoside biosynthetic process (GO:0046129) | 3.20156855 |
107 | regulation of actin filament-based movement (GO:1903115) | 3.16766504 |
108 | protein localization to mitochondrion (GO:0070585) | 3.15972806 |
109 | ketone body metabolic process (GO:1902224) | 3.15862826 |
110 | macromolecular complex disassembly (GO:0032984) | 3.15185207 |
111 | iron-sulfur cluster assembly (GO:0016226) | 3.13989855 |
112 | metallo-sulfur cluster assembly (GO:0031163) | 3.13989855 |
113 | aspartate family amino acid catabolic process (GO:0009068) | 3.13644346 |
114 | nucleoside monophosphate biosynthetic process (GO:0009124) | 3.13638899 |
115 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.13363475 |
116 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.13229324 |
117 | cytidine metabolic process (GO:0046087) | 3.12850556 |
118 | cytidine catabolic process (GO:0006216) | 3.12850556 |
119 | cytidine deamination (GO:0009972) | 3.12850556 |
120 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.11968215 |
121 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.11968215 |
122 | mRNA catabolic process (GO:0006402) | 3.11619431 |
123 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.03032583 |
124 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.02561798 |
125 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.99993736 |
126 | cullin deneddylation (GO:0010388) | 2.94825144 |
127 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.94313455 |
128 | spliceosomal snRNP assembly (GO:0000387) | 2.94309560 |
129 | rRNA processing (GO:0006364) | 2.93185857 |
130 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.89603553 |
131 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.89603553 |
132 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.89603553 |
133 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.88560183 |
134 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.88560183 |
135 | protein targeting (GO:0006605) | 2.86640840 |
136 | RNA catabolic process (GO:0006401) | 2.85352109 |
137 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.85020384 |
138 | base-excision repair, AP site formation (GO:0006285) | 2.82716806 |
139 | rRNA metabolic process (GO:0016072) | 2.79735900 |
140 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 10.3345529 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.16302905 |
2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.71222503 |
3 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 3.77225731 |
4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.67661868 |
5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.66751651 |
6 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.41100247 |
7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.31513488 |
8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.18019742 |
9 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.04790465 |
10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.00148216 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.99616457 |
12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.96536323 |
13 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.79525345 |
14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.64219017 |
15 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.57392500 |
16 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.55040277 |
17 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.36257621 |
18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.28349768 |
19 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.25324942 |
20 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.19921936 |
21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.19366466 |
22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.17150268 |
23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.14069510 |
24 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.12860492 |
25 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.10998668 |
26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.10911621 |
27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.10392841 |
28 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 2.04933235 |
29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.02368692 |
30 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.01154638 |
31 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.98498792 |
32 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.77257995 |
33 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.73884678 |
34 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.73361813 |
35 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72520501 |
36 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.72338792 |
37 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.71063633 |
38 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.68044080 |
39 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.66253651 |
40 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.65862647 |
41 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.60753304 |
42 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.60361918 |
43 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.60076089 |
44 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.58551327 |
45 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.57161576 |
46 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.57077728 |
47 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.53967481 |
48 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.50474461 |
49 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.49065549 |
50 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.48424681 |
51 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.46937516 |
52 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.46412047 |
53 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.44902864 |
54 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.40435025 |
55 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38266171 |
56 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35981719 |
57 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.32837423 |
58 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.31981277 |
59 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.31001193 |
60 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.24381825 |
61 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.19708056 |
62 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.18642218 |
63 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.17309080 |
64 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.17031061 |
65 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.16179548 |
66 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.15795626 |
67 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.13220495 |
68 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.13182653 |
69 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.12889781 |
70 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.11975090 |
71 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.11705409 |
72 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.10910085 |
73 | * POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10784868 |
74 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.10361673 |
75 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.08905976 |
76 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.08275577 |
77 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.06994547 |
78 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.04988370 |
79 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.04767344 |
80 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.04743543 |
81 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.04410049 |
82 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.03162617 |
83 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.02668848 |
84 | VDR_22108803_ChIP-Seq_LS180_Human | 1.02084292 |
85 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.01457665 |
86 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.00716077 |
87 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.00628829 |
88 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.00139791 |
89 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.99651299 |
90 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.99417793 |
91 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98753724 |
92 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.98013493 |
93 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.97369640 |
94 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.97018637 |
95 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.96233747 |
96 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.95737474 |
97 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.95651212 |
98 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.92925112 |
99 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92862498 |
100 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.92469055 |
101 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.92361946 |
102 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.92330532 |
103 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.92180556 |
104 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.92004295 |
105 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.91517301 |
106 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.90617810 |
107 | SA1_27219007_Chip-Seq_Bcells_Human | 0.90492846 |
108 | P68_20966046_ChIP-Seq_HELA_Human | 0.88683217 |
109 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.88542628 |
110 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.88168148 |
111 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.88120839 |
112 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.88073167 |
113 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.86730308 |
114 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.85780811 |
115 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.85335061 |
116 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.83676987 |
117 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83499864 |
118 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.83278477 |
119 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.81288154 |
120 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.80889876 |
121 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.80740333 |
122 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.78808221 |
123 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.77120136 |
124 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.76799117 |
125 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.76305057 |
126 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.75960401 |
127 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.75874066 |
128 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.73887552 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002837_dystrophic_cardiac_calcinosis | 5.89124315 |
2 | MP0003646_muscle_fatigue | 5.86520695 |
3 | MP0004215_abnormal_myocardial_fiber | 4.27880692 |
4 | MP0004084_abnormal_cardiac_muscle | 4.18522407 |
5 | MP0000751_myopathy | 4.02720151 |
6 | MP0006036_abnormal_mitochondrial_physio | 3.87851575 |
7 | MP0005330_cardiomyopathy | 3.57162472 |
8 | MP0000749_muscle_degeneration | 3.54376535 |
9 | MP0004036_abnormal_muscle_relaxation | 3.21871288 |
10 | MP0003806_abnormal_nucleotide_metabolis | 2.67711146 |
11 | MP0003137_abnormal_impulse_conducting | 2.59422865 |
12 | MP0006035_abnormal_mitochondrial_morpho | 2.54842619 |
13 | MP0002972_abnormal_cardiac_muscle | 2.48989255 |
14 | MP0009379_abnormal_foot_pigmentation | 2.48002429 |
15 | MP0006292_abnormal_olfactory_placode | 2.38687576 |
16 | MP0008775_abnormal_heart_ventricle | 2.37046609 |
17 | MP0000750_abnormal_muscle_regeneration | 2.35051684 |
18 | MP0004043_abnormal_pH_regulation | 2.34787321 |
19 | MP0004087_abnormal_muscle_fiber | 2.30553865 |
20 | MP0004484_altered_response_of | 2.17272548 |
21 | MP0003011_delayed_dark_adaptation | 2.16133650 |
22 | MP0003136_yellow_coat_color | 2.09840207 |
23 | MP0004130_abnormal_muscle_cell | 2.07450408 |
24 | MP0005385_cardiovascular_system_phenoty | 2.04705360 |
25 | MP0001544_abnormal_cardiovascular_syste | 2.04705360 |
26 | MP0005620_abnormal_muscle_contractility | 2.03061637 |
27 | MP0003221_abnormal_cardiomyocyte_apopto | 1.96802987 |
28 | MP0002106_abnormal_muscle_physiology | 1.91908341 |
29 | MP0002269_muscular_atrophy | 1.86488504 |
30 | MP0003186_abnormal_redox_activity | 1.79843712 |
31 | MP0002277_abnormal_respiratory_mucosa | 1.78918371 |
32 | MP0002638_abnormal_pupillary_reflex | 1.78257398 |
33 | MP0000747_muscle_weakness | 1.67072563 |
34 | MP0010630_abnormal_cardiac_muscle | 1.66676407 |
35 | MP0005360_urolithiasis | 1.66063123 |
36 | MP0004145_abnormal_muscle_electrophysio | 1.63494650 |
37 | MP0004147_increased_porphyrin_level | 1.62020304 |
38 | MP0006138_congestive_heart_failure | 1.61792646 |
39 | MP0003718_maternal_effect | 1.56461764 |
40 | MP0000759_abnormal_skeletal_muscle | 1.55343667 |
41 | MP0009046_muscle_twitch | 1.54956229 |
42 | MP0005266_abnormal_metabolism | 1.52675856 |
43 | MP0002822_catalepsy | 1.48293583 |
44 | MP0004085_abnormal_heartbeat | 1.47013797 |
45 | MP0002332_abnormal_exercise_endurance | 1.46751589 |
46 | MP0005332_abnormal_amino_acid | 1.46552481 |
47 | MP0005369_muscle_phenotype | 1.45649299 |
48 | MP0001529_abnormal_vocalization | 1.41380135 |
49 | MP0002272_abnormal_nervous_system | 1.37801534 |
50 | MP0005085_abnormal_gallbladder_physiolo | 1.36655816 |
51 | MP0003195_calcinosis | 1.36566222 |
52 | MP0002938_white_spotting | 1.34471690 |
53 | MP0005646_abnormal_pituitary_gland | 1.33451568 |
54 | MP0003828_pulmonary_edema | 1.31711078 |
55 | MP0006072_abnormal_retinal_apoptosis | 1.30532740 |
56 | MP0005666_abnormal_adipose_tissue | 1.29287314 |
57 | MP0005636_abnormal_mineral_homeostasis | 1.28939854 |
58 | MP0001968_abnormal_touch/_nociception | 1.28707432 |
59 | MP0002653_abnormal_ependyma_morphology | 1.28461585 |
60 | MP0009745_abnormal_behavioral_response | 1.28014921 |
61 | MP0008995_early_reproductive_senescence | 1.26637777 |
62 | MP0005083_abnormal_biliary_tract | 1.26177190 |
63 | MP0008058_abnormal_DNA_repair | 1.25797921 |
64 | MP0003656_abnormal_erythrocyte_physiolo | 1.24518655 |
65 | MP0004019_abnormal_vitamin_homeostasis | 1.24093216 |
66 | MP0005645_abnormal_hypothalamus_physiol | 1.22279641 |
67 | MP0000343_altered_response_to | 1.20615870 |
68 | MP0001984_abnormal_olfaction | 1.19065429 |
69 | MP0004233_abnormal_muscle_weight | 1.19057171 |
70 | MP0009643_abnormal_urine_homeostasis | 1.18431592 |
71 | MP0003786_premature_aging | 1.15785483 |
72 | MP0010030_abnormal_orbit_morphology | 1.14900674 |
73 | MP0002163_abnormal_gland_morphology | 1.14811062 |
74 | MP0005451_abnormal_body_composition | 1.14618003 |
75 | MP0005165_increased_susceptibility_to | 1.14296639 |
76 | MP0002139_abnormal_hepatobiliary_system | 1.11556827 |
77 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.11321171 |
78 | MP0005423_abnormal_somatic_nervous | 1.11029755 |
79 | MP0005319_abnormal_enzyme/_coenzyme | 1.10556314 |
80 | MP0005551_abnormal_eye_electrophysiolog | 1.09151473 |
81 | MP0003567_abnormal_fetal_cardiomyocyte | 1.07318498 |
82 | MP0003123_paternal_imprinting | 1.05128751 |
83 | MP0002064_seizures | 1.04134271 |
84 | MP0002127_abnormal_cardiovascular_syste | 1.01317342 |
85 | MP0004142_abnormal_muscle_tone | 1.00057406 |
86 | MP0005670_abnormal_white_adipose | 0.99276908 |
87 | MP0003938_abnormal_ear_development | 0.98600933 |
88 | MP0000230_abnormal_systemic_arterial | 0.97447383 |
89 | MP0004742_abnormal_vestibular_system | 0.96563589 |
90 | MP0002734_abnormal_mechanical_nocicepti | 0.94488411 |
91 | MP0002876_abnormal_thyroid_physiology | 0.93699535 |
92 | MP0008789_abnormal_olfactory_epithelium | 0.92647419 |
93 | MP0003878_abnormal_ear_physiology | 0.92107455 |
94 | MP0005377_hearing/vestibular/ear_phenot | 0.92107455 |
95 | MP0008875_abnormal_xenobiotic_pharmacok | 0.91261205 |
96 | MP0003283_abnormal_digestive_organ | 0.90788537 |
97 | MP0004957_abnormal_blastocyst_morpholog | 0.90662772 |
98 | MP0002160_abnormal_reproductive_system | 0.90406654 |
99 | MP0002234_abnormal_pharynx_morphology | 0.87549174 |
100 | MP0000631_abnormal_neuroendocrine_gland | 0.86673225 |
101 | MP0001756_abnormal_urination | 0.85550519 |
102 | MP0003879_abnormal_hair_cell | 0.85494946 |
103 | MP0001986_abnormal_taste_sensitivity | 0.84735435 |
104 | MP0010386_abnormal_urinary_bladder | 0.82084264 |
105 | MP0009840_abnormal_foam_cell | 0.81920904 |
106 | MP0000358_abnormal_cell_content/ | 0.81530434 |
107 | MP0000049_abnormal_middle_ear | 0.81464132 |
108 | MP0001663_abnormal_digestive_system | 0.80925711 |
109 | MP0001970_abnormal_pain_threshold | 0.79917321 |
110 | MP0005535_abnormal_body_temperature | 0.79293311 |
111 | MP0005253_abnormal_eye_physiology | 0.78163485 |
112 | MP0002909_abnormal_adrenal_gland | 0.76998025 |
113 | MP0002132_abnormal_respiratory_system | 0.76843056 |
114 | MP0001765_abnormal_ion_homeostasis | 0.76679368 |
115 | MP0005408_hypopigmentation | 0.76514391 |
116 | MP0002733_abnormal_thermal_nociception | 0.75850679 |
117 | MP0002102_abnormal_ear_morphology | 0.75161586 |
118 | MP0000026_abnormal_inner_ear | 0.73696340 |
119 | MP0006276_abnormal_autonomic_nervous | 0.72855799 |
120 | MP0005376_homeostasis/metabolism_phenot | 0.72412802 |
121 | MP0002095_abnormal_skin_pigmentation | 0.71216948 |
122 | MP0001486_abnormal_startle_reflex | 0.71021082 |
123 | MP0003693_abnormal_embryo_hatching | 0.70847476 |
124 | MP0004133_heterotaxia | 0.70428155 |
125 | MP0000013_abnormal_adipose_tissue | 0.70414527 |
126 | MP0005379_endocrine/exocrine_gland_phen | 0.70001139 |
127 | MP0000372_irregular_coat_pigmentation | 0.69820058 |
128 | MP0008872_abnormal_physiological_respon | 0.68895858 |
129 | MP0005075_abnormal_melanosome_morpholog | 0.68309220 |
130 | MP0005389_reproductive_system_phenotype | 0.68006200 |
131 | MP0003638_abnormal_response/metabolism_ | 0.67943520 |
132 | MP0004510_myositis | 0.64407679 |
133 | MP0001764_abnormal_homeostasis | 0.64407491 |
134 | MP0002971_abnormal_brown_adipose | 0.63696777 |
135 | MP0005375_adipose_tissue_phenotype | 0.63374958 |
136 | MP0004185_abnormal_adipocyte_glucose | 0.63035983 |
137 | MP0005381_digestive/alimentary_phenotyp | 0.62637778 |
138 | MP0002078_abnormal_glucose_homeostasis | 0.62365046 |
139 | MP0002118_abnormal_lipid_homeostasis | 0.58482354 |
140 | MP0005084_abnormal_gallbladder_morpholo | 0.55323588 |
141 | MP0003880_abnormal_central_pattern | 0.55117122 |
142 | MP0000266_abnormal_heart_morphology | 0.54139534 |
143 | MP0004924_abnormal_behavior | 0.53962553 |
144 | MP0005386_behavior/neurological_phenoty | 0.53962553 |
145 | MP0001905_abnormal_dopamine_level | 0.53669113 |
146 | MP0001485_abnormal_pinna_reflex | 0.53470910 |
147 | MP0003315_abnormal_perineum_morphology | 0.52785284 |
148 | MP0008932_abnormal_embryonic_tissue | 0.50399186 |
149 | MP0005365_abnormal_bile_salt | 0.48994465 |
150 | MP0001727_abnormal_embryo_implantation | 0.47585608 |
151 | MP0002736_abnormal_nociception_after | 0.45873645 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 6.52767035 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.32000970 |
3 | Mitochondrial inheritance (HP:0001427) | 5.98404883 |
4 | Acute encephalopathy (HP:0006846) | 5.83033283 |
5 | Hepatocellular necrosis (HP:0001404) | 5.71219301 |
6 | Hepatic necrosis (HP:0002605) | 5.69970715 |
7 | Progressive macrocephaly (HP:0004481) | 5.41157408 |
8 | Increased CSF lactate (HP:0002490) | 5.36673360 |
9 | Increased intramyocellular lipid droplets (HP:0012240) | 4.78875919 |
10 | Increased muscle lipid content (HP:0009058) | 4.75568878 |
11 | Sudden death (HP:0001699) | 4.69873778 |
12 | Lipid accumulation in hepatocytes (HP:0006561) | 4.67514047 |
13 | Increased hepatocellular lipid droplets (HP:0006565) | 4.62314269 |
14 | Cerebral edema (HP:0002181) | 4.57623379 |
15 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.48666261 |
16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.48666261 |
17 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.28632685 |
18 | Lactic acidosis (HP:0003128) | 4.23358940 |
19 | Respiratory failure (HP:0002878) | 4.02983426 |
20 | Exercise intolerance (HP:0003546) | 3.97380470 |
21 | Ventricular tachycardia (HP:0004756) | 3.82903975 |
22 | Increased serum lactate (HP:0002151) | 3.77987062 |
23 | Myoglobinuria (HP:0002913) | 3.65820305 |
24 | Palpitations (HP:0001962) | 3.57617068 |
25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.51785188 |
26 | Renal Fanconi syndrome (HP:0001994) | 3.48068978 |
27 | Rhabdomyolysis (HP:0003201) | 3.40292679 |
28 | Dicarboxylic aciduria (HP:0003215) | 3.34726405 |
29 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.34726405 |
30 | Calf muscle hypertrophy (HP:0008981) | 3.33534539 |
31 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.31156713 |
32 | Abnormal number of erythroid precursors (HP:0012131) | 3.27039262 |
33 | Abnormality of glycolysis (HP:0004366) | 3.23323698 |
34 | Increased serum pyruvate (HP:0003542) | 3.23323698 |
35 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.14741353 |
36 | Exercise-induced muscle cramps (HP:0003710) | 3.11787849 |
37 | Myokymia (HP:0002411) | 3.09374195 |
38 | Lipoatrophy (HP:0100578) | 3.08049217 |
39 | Optic disc pallor (HP:0000543) | 3.06280890 |
40 | Exertional dyspnea (HP:0002875) | 3.06151254 |
41 | Exercise-induced myalgia (HP:0003738) | 3.01656049 |
42 | Leukodystrophy (HP:0002415) | 2.95192711 |
43 | Atrial fibrillation (HP:0005110) | 2.94674854 |
44 | Lethargy (HP:0001254) | 2.91716601 |
45 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.88027117 |
46 | Supraventricular tachycardia (HP:0004755) | 2.87636953 |
47 | Ventricular fibrillation (HP:0001663) | 2.81849422 |
48 | Primary atrial arrhythmia (HP:0001692) | 2.80706385 |
49 | Glycosuria (HP:0003076) | 2.80666684 |
50 | Abnormality of urine glucose concentration (HP:0011016) | 2.80666684 |
51 | Supraventricular arrhythmia (HP:0005115) | 2.79950779 |
52 | Ragged-red muscle fibers (HP:0003200) | 2.78548360 |
53 | Respiratory difficulties (HP:0002880) | 2.76724581 |
54 | Syncope (HP:0001279) | 2.76410018 |
55 | Muscle fiber splitting (HP:0003555) | 2.74284195 |
56 | Dilated cardiomyopathy (HP:0001644) | 2.70719466 |
57 | Ketoacidosis (HP:0001993) | 2.69616945 |
58 | Generalized aminoaciduria (HP:0002909) | 2.69269130 |
59 | CNS demyelination (HP:0007305) | 2.68753814 |
60 | Conjunctival hamartoma (HP:0100780) | 2.63961272 |
61 | Hypoglycemic coma (HP:0001325) | 2.62401679 |
62 | Prolonged QT interval (HP:0001657) | 2.60446503 |
63 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.59523571 |
64 | Abnormality of alanine metabolism (HP:0010916) | 2.59523571 |
65 | Hyperalaninemia (HP:0003348) | 2.59523571 |
66 | Abnormality of the calf musculature (HP:0001430) | 2.58267801 |
67 | 3-Methylglutaconic aciduria (HP:0003535) | 2.58138463 |
68 | Nemaline bodies (HP:0003798) | 2.51930676 |
69 | Muscle fiber inclusion bodies (HP:0100299) | 2.51303424 |
70 | Pallor (HP:0000980) | 2.50877288 |
71 | Hyperphosphaturia (HP:0003109) | 2.47428955 |
72 | Emotional lability (HP:0000712) | 2.46017493 |
73 | Reticulocytopenia (HP:0001896) | 2.43962618 |
74 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.42679478 |
75 | Right ventricular cardiomyopathy (HP:0011663) | 2.40715526 |
76 | Vomiting (HP:0002013) | 2.39976768 |
77 | Type I transferrin isoform profile (HP:0003642) | 2.39923012 |
78 | Nausea (HP:0002018) | 2.39546282 |
79 | Hyperammonemia (HP:0001987) | 2.32525147 |
80 | Macrocytic anemia (HP:0001972) | 2.31515782 |
81 | Neuroendocrine neoplasm (HP:0100634) | 2.31027164 |
82 | Pheochromocytoma (HP:0002666) | 2.30570356 |
83 | Ventricular arrhythmia (HP:0004308) | 2.30146736 |
84 | Ketosis (HP:0001946) | 2.29687421 |
85 | Muscle stiffness (HP:0003552) | 2.28051742 |
86 | Myotonia (HP:0002486) | 2.27932506 |
87 | Abnormality of renal resorption (HP:0011038) | 2.26783205 |
88 | Aplastic anemia (HP:0001915) | 2.24004070 |
89 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.23657300 |
90 | Multiple enchondromatosis (HP:0005701) | 2.22917774 |
91 | Esophageal neoplasm (HP:0100751) | 2.19115861 |
92 | Neoplasm of head and neck (HP:0012288) | 2.19115861 |
93 | Bundle branch block (HP:0011710) | 2.19005479 |
94 | Hyperglycinuria (HP:0003108) | 2.16958421 |
95 | Proximal tubulopathy (HP:0000114) | 2.16753990 |
96 | Subaortic stenosis (HP:0001682) | 2.12372161 |
97 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.12372161 |
98 | Metabolic acidosis (HP:0001942) | 2.12182169 |
99 | EMG: myopathic abnormalities (HP:0003458) | 2.10479785 |
100 | Methylmalonic aciduria (HP:0012120) | 2.08710748 |
101 | Abnormal EKG (HP:0003115) | 2.07215914 |
102 | Progressive muscle weakness (HP:0003323) | 2.06412181 |
103 | Abnormal urine phosphate concentration (HP:0012599) | 2.03110338 |
104 | Congenital, generalized hypertrichosis (HP:0004540) | 2.02077140 |
105 | Gliosis (HP:0002171) | 2.01358010 |
106 | Asymmetric septal hypertrophy (HP:0001670) | 1.99148313 |
107 | Heart block (HP:0012722) | 1.91906612 |
108 | Hyperglycinemia (HP:0002154) | 1.91147125 |
109 | X-linked dominant inheritance (HP:0001423) | 1.90893414 |
110 | Testicular atrophy (HP:0000029) | 1.90769415 |
111 | Oral leukoplakia (HP:0002745) | 1.89435401 |
112 | Blindness (HP:0000618) | 1.85079737 |
113 | Degeneration of anterior horn cells (HP:0002398) | 1.81362660 |
114 | Abnormality of the anterior horn cell (HP:0006802) | 1.81362660 |
115 | Microvesicular hepatic steatosis (HP:0001414) | 1.74403537 |
116 | Abnormal protein glycosylation (HP:0012346) | 1.74166297 |
117 | Abnormal glycosylation (HP:0012345) | 1.74166297 |
118 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.74166297 |
119 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.74166297 |
120 | Renal tubular dysfunction (HP:0000124) | 1.71323443 |
121 | Pancytopenia (HP:0001876) | 1.68552963 |
122 | Muscle fiber atrophy (HP:0100295) | 1.67919334 |
123 | Cerebral hypomyelination (HP:0006808) | 1.67362010 |
124 | Abnormality of serum amino acid levels (HP:0003112) | 1.65563690 |
125 | Reduced antithrombin III activity (HP:0001976) | 1.64109395 |
126 | Abnormality of magnesium homeostasis (HP:0004921) | 1.63676752 |
127 | Type 2 muscle fiber atrophy (HP:0003554) | 1.63471297 |
128 | Methylmalonic acidemia (HP:0002912) | 1.62995994 |
129 | Myopathic facies (HP:0002058) | 1.60375279 |
130 | Absent thumb (HP:0009777) | 1.57466731 |
131 | Progressive microcephaly (HP:0000253) | 1.54450364 |
132 | Poor suck (HP:0002033) | 1.53660091 |
133 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.51552758 |
134 | Molar tooth sign on MRI (HP:0002419) | 1.50269857 |
135 | Abnormality of midbrain morphology (HP:0002418) | 1.50269857 |
136 | Paralysis (HP:0003470) | 1.50119780 |
137 | Sparse eyelashes (HP:0000653) | 1.49100046 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 5.01404627 |
2 | NME2 | 3.99261089 |
3 | BCKDK | 3.94347011 |
4 | MYLK | 3.61568874 |
5 | LMTK2 | 3.46702881 |
6 | TLK1 | 3.28217296 |
7 | NME1 | 3.26206440 |
8 | OBSCN | 3.00207145 |
9 | NEK1 | 2.78842079 |
10 | TTN | 2.62978521 |
11 | PDK4 | 2.48615751 |
12 | PDK3 | 2.48615751 |
13 | STK16 | 2.37710901 |
14 | PHKG1 | 2.23439053 |
15 | PHKG2 | 2.23439053 |
16 | WNK4 | 2.21350303 |
17 | MUSK | 2.15537992 |
18 | MAP3K11 | 1.97479337 |
19 | PIK3CA | 1.82754918 |
20 | EIF2AK1 | 1.76741304 |
21 | CDC7 | 1.74423665 |
22 | ILK | 1.74151566 |
23 | DAPK3 | 1.73826394 |
24 | BUB1 | 1.67485558 |
25 | TESK2 | 1.66801046 |
26 | DYRK2 | 1.66763444 |
27 | PINK1 | 1.55275523 |
28 | MAP3K12 | 1.53459529 |
29 | ARAF | 1.52346918 |
30 | NUAK1 | 1.52244744 |
31 | KDR | 1.51630940 |
32 | PKN2 | 1.47769319 |
33 | WEE1 | 1.45580338 |
34 | MST4 | 1.42354672 |
35 | MST1R | 1.36985376 |
36 | VRK1 | 1.35307897 |
37 | PDK2 | 1.30399446 |
38 | GRK7 | 1.24549279 |
39 | CAMK2D | 1.21196521 |
40 | PIM2 | 1.21005964 |
41 | LIMK1 | 1.20999943 |
42 | MAP2K7 | 1.19114459 |
43 | MAPKAPK3 | 1.18777466 |
44 | ABL2 | 1.18049410 |
45 | CDK19 | 1.10466108 |
46 | STK39 | 1.09279260 |
47 | SRPK1 | 1.08356888 |
48 | MAP4K2 | 1.07747818 |
49 | GRK1 | 1.07591576 |
50 | ADRBK2 | 1.05991381 |
51 | TESK1 | 0.98903316 |
52 | TAOK3 | 0.98339087 |
53 | RPS6KA5 | 0.97682758 |
54 | INSRR | 0.90992575 |
55 | ZAK | 0.88627410 |
56 | DMPK | 0.87578196 |
57 | CSNK1G3 | 0.86836316 |
58 | BRAF | 0.85696274 |
59 | CAMK2G | 0.83517573 |
60 | BMPR1B | 0.80390294 |
61 | TRIB3 | 0.79665446 |
62 | STK24 | 0.76705599 |
63 | CSNK1G2 | 0.75979225 |
64 | CCNB1 | 0.75789025 |
65 | EPHB2 | 0.74554193 |
66 | LRRK2 | 0.74435967 |
67 | FLT3 | 0.73814213 |
68 | PRKG2 | 0.73691729 |
69 | PLK4 | 0.71231012 |
70 | MAP2K2 | 0.69897588 |
71 | AURKA | 0.69573145 |
72 | WNK3 | 0.68218946 |
73 | CSNK1G1 | 0.65903981 |
74 | PRKCG | 0.65171079 |
75 | SCYL2 | 0.63857983 |
76 | TIE1 | 0.62610832 |
77 | STK4 | 0.61191033 |
78 | PKN1 | 0.59825164 |
79 | PLK3 | 0.59529225 |
80 | AURKB | 0.58940067 |
81 | CDK8 | 0.54826994 |
82 | MAP2K6 | 0.54783742 |
83 | PBK | 0.53980432 |
84 | ROCK1 | 0.52773416 |
85 | OXSR1 | 0.52760278 |
86 | AKT2 | 0.50763227 |
87 | PRKD1 | 0.49529353 |
88 | EPHA4 | 0.49418214 |
89 | CAMK2B | 0.49272852 |
90 | MINK1 | 0.48757861 |
91 | CAMK2A | 0.48512165 |
92 | GRK6 | 0.46678542 |
93 | CSNK1A1 | 0.46469184 |
94 | MAPK15 | 0.45935219 |
95 | MAPKAPK5 | 0.45762804 |
96 | PRKACA | 0.44751188 |
97 | CAMK1 | 0.44084748 |
98 | PAK1 | 0.43607523 |
99 | RPS6KB2 | 0.43535077 |
100 | CHEK2 | 0.42277525 |
101 | BRSK1 | 0.42237002 |
102 | PAK3 | 0.41597752 |
103 | ROCK2 | 0.41301390 |
104 | CSNK2A2 | 0.39667885 |
105 | ADRBK1 | 0.39237786 |
106 | PRKCA | 0.37942557 |
107 | TTK | 0.37475868 |
108 | CSNK1A1L | 0.37101783 |
109 | CSNK2A1 | 0.36583524 |
110 | PLK1 | 0.35843300 |
111 | MAP3K5 | 0.35496505 |
112 | KSR2 | 0.34843978 |
113 | MAP3K8 | 0.33665810 |
114 | TAOK2 | 0.33442991 |
115 | UHMK1 | 0.33063438 |
116 | CSNK1E | 0.32953188 |
117 | PRKAA2 | 0.32229367 |
118 | PRKG1 | 0.31874490 |
119 | RAF1 | 0.30985434 |
120 | TBK1 | 0.30831593 |
121 | MAPK11 | 0.30627720 |
122 | MAP3K7 | 0.30407145 |
123 | CAMKK2 | 0.30192777 |
124 | PRKACG | 0.29709900 |
125 | PRKCD | 0.29438295 |
126 | PRKCI | 0.29422094 |
127 | TNIK | 0.28085472 |
128 | MAPK12 | 0.27508966 |
129 | DYRK3 | 0.26527198 |
130 | PTK2B | 0.25973230 |
131 | STK38L | 0.25712463 |
132 | GRK5 | 0.24705431 |
133 | RPS6KL1 | 0.24521241 |
134 | RPS6KC1 | 0.24521241 |
135 | DAPK1 | 0.24406499 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.76265606 |
2 | Parkinsons disease_Homo sapiens_hsa05012 | 5.32171697 |
3 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.37498503 |
4 | Alzheimers disease_Homo sapiens_hsa05010 | 3.84313136 |
5 | Ribosome_Homo sapiens_hsa03010 | 3.74266083 |
6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.65926755 |
7 | * Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.46709019 |
8 | * Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.46662457 |
9 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.93549566 |
10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.53385237 |
11 | Carbon metabolism_Homo sapiens_hsa01200 | 2.21585328 |
12 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.02794809 |
13 | Proteasome_Homo sapiens_hsa03050 | 2.02772846 |
14 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.00792978 |
15 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.95025868 |
16 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.88938977 |
17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.80797750 |
18 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.64087211 |
19 | Sulfur relay system_Homo sapiens_hsa04122 | 1.60293770 |
20 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.51994464 |
21 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.50859663 |
22 | RNA polymerase_Homo sapiens_hsa03020 | 1.48980800 |
23 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.33234581 |
24 | DNA replication_Homo sapiens_hsa03030 | 1.28918683 |
25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.25686731 |
26 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.25258887 |
27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.18698706 |
28 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.17414312 |
29 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.15064344 |
30 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.12951265 |
31 | Peroxisome_Homo sapiens_hsa04146 | 0.95384071 |
32 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.93152339 |
33 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.91065762 |
34 | Protein export_Homo sapiens_hsa03060 | 0.89573927 |
35 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.87801385 |
36 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.87682035 |
37 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.86723781 |
38 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.85834989 |
39 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.84333508 |
40 | Mismatch repair_Homo sapiens_hsa03430 | 0.83023496 |
41 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.82254114 |
42 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.81026296 |
43 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.80797627 |
44 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.79126813 |
45 | Galactose metabolism_Homo sapiens_hsa00052 | 0.70953149 |
46 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.67867952 |
47 | Basal transcription factors_Homo sapiens_hsa03022 | 0.66434044 |
48 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.66413723 |
49 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.66265005 |
50 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.66022697 |
51 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.61867863 |
52 | Homologous recombination_Homo sapiens_hsa03440 | 0.61186918 |
53 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.60692640 |
54 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.59544646 |
55 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.59274365 |
56 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.58470539 |
57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.58453103 |
58 | Purine metabolism_Homo sapiens_hsa00230 | 0.58265615 |
59 | Spliceosome_Homo sapiens_hsa03040 | 0.56539446 |
60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.55677446 |
61 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.53206278 |
62 | Mineral absorption_Homo sapiens_hsa04978 | 0.50139914 |
63 | Phototransduction_Homo sapiens_hsa04744 | 0.50033128 |
64 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.49620541 |
65 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.49511306 |
66 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.49386293 |
67 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.48234696 |
68 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.45284173 |
69 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.45016310 |
70 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.44138646 |
71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.40500789 |
72 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.40437495 |
73 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.39298954 |
74 | Nicotine addiction_Homo sapiens_hsa05033 | 0.38585023 |
75 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.38391187 |
76 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.38163129 |
77 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36908600 |
78 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.35342206 |
79 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.33844480 |
80 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.33463378 |
81 | Base excision repair_Homo sapiens_hsa03410 | 0.32906889 |
82 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.32814999 |
83 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.32091508 |
84 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.31670937 |
85 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.31167120 |
86 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.31102761 |
87 | Asthma_Homo sapiens_hsa05310 | 0.29690027 |
88 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29441323 |
89 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.29356341 |
90 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.28764111 |
91 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.27658716 |
92 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27084019 |
93 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.25021699 |
94 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.24636275 |
95 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.24042550 |
96 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.23130383 |
97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.21745807 |
98 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.20897968 |
99 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.20852351 |
100 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.19575084 |
101 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.18387693 |
102 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.18294921 |
103 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.16600715 |
104 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.15422692 |
105 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.14664029 |
106 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.14465788 |
107 | Bile secretion_Homo sapiens_hsa04976 | 0.11992986 |
108 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.11679144 |
109 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.11248025 |
110 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.09696892 |
111 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.09008309 |
112 | RNA degradation_Homo sapiens_hsa03018 | 0.08423622 |
113 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.08140905 |
114 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.07496940 |
115 | RNA transport_Homo sapiens_hsa03013 | 0.06096010 |
116 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.05811684 |
117 | Histidine metabolism_Homo sapiens_hsa00340 | 0.02026004 |
118 | Viral myocarditis_Homo sapiens_hsa05416 | 0.00800948 |
119 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | -0.0357941 |
120 | Calcium signaling pathway_Homo sapiens_hsa04020 | -0.0233018 |
121 | Alcoholism_Homo sapiens_hsa05034 | -0.0164729 |