COX5BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)9.44118571
2growth hormone secretion (GO:0030252)7.26310959
3ganglion development (GO:0061548)6.98296862
4skeletal muscle adaptation (GO:0043501)6.26183752
5muscle atrophy (GO:0014889)6.14745147
6striated muscle atrophy (GO:0014891)6.04485200
7negative regulation of muscle hypertrophy (GO:0014741)5.82936866
8regulation of skeletal muscle contraction (GO:0014819)5.57981037
9response to folic acid (GO:0051593)5.11500052
10skeletal muscle tissue regeneration (GO:0043403)4.92621087
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.79037827
12actin-myosin filament sliding (GO:0033275)4.75264819
13muscle filament sliding (GO:0030049)4.75264819
14regulation of transcription involved in cell fate commitment (GO:0060850)4.74678767
15galactose catabolic process (GO:0019388)4.67484691
16galactose metabolic process (GO:0006012)4.66173913
17positive regulation of endothelial cell differentiation (GO:0045603)4.55743432
18regulation of timing of cell differentiation (GO:0048505)4.54683198
19purine nucleotide salvage (GO:0032261)4.38689776
20positive regulation of growth hormone secretion (GO:0060124)4.38288393
21cerebral cortex neuron differentiation (GO:0021895)4.37014712
22negative regulation of catenin import into nucleus (GO:0035414)4.34735014
23spinal cord association neuron differentiation (GO:0021527)4.32215830
24response to muscle activity (GO:0014850)4.30936780
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.28362854
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.28362854
27lung secretory cell differentiation (GO:0061140)4.24976079
28secondary heart field specification (GO:0003139)4.14266636
29heart field specification (GO:0003128)4.14266636
30negative regulation of oligodendrocyte differentiation (GO:0048715)4.12463984
31negative regulation of skeletal muscle tissue development (GO:0048642)4.08354349
32auditory behavior (GO:0031223)3.94895148
33protein retention in ER lumen (GO:0006621)3.93477813
34positive regulation of actin filament depolymerization (GO:0030836)3.91938707
35epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.89384084
36microtubule nucleation (GO:0007020)3.88298352
37regulation of development, heterochronic (GO:0040034)3.85364662
38actin-mediated cell contraction (GO:0070252)3.84574820
39protein maturation by protein folding (GO:0022417)3.73249932
40regulation of plasminogen activation (GO:0010755)3.67532564
41alternative mRNA splicing, via spliceosome (GO:0000380)3.66730476
42multicellular organismal movement (GO:0050879)3.60985478
43musculoskeletal movement (GO:0050881)3.60985478
44mesenchymal cell differentiation involved in renal system development (GO:2001012)3.58248965
45mesenchymal cell differentiation involved in kidney development (GO:0072161)3.58248965
46adenosine metabolic process (GO:0046085)3.46908011
47negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.45824101
48postsynaptic membrane organization (GO:0001941)3.41827349
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.40472788
50mesonephros development (GO:0001823)3.38839335
51desmosome organization (GO:0002934)3.35281335
52regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.23314994
53white fat cell differentiation (GO:0050872)3.21630225
54cullin deneddylation (GO:0010388)3.20887244
55regulation of tight junction assembly (GO:2000810)3.18636924
56regulation of endothelial cell differentiation (GO:0045601)3.16023991
57positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.09217962
58homocysteine metabolic process (GO:0050667)3.08142894
59response to activity (GO:0014823)3.07474716
60membrane assembly (GO:0071709)3.04189931
61monocyte differentiation (GO:0030224)3.03298819
62regulation of gonadotropin secretion (GO:0032276)3.01900164
63cartilage morphogenesis (GO:0060536)3.00720220
64response to inactivity (GO:0014854)2.99950979
65response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.97512378
66positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.95917437
67DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.95481585
68forebrain neuron differentiation (GO:0021879)2.94170426
69phosphatidylglycerol biosynthetic process (GO:0006655)2.92402975
70barbed-end actin filament capping (GO:0051016)2.92266727
71synaptic vesicle maturation (GO:0016188)2.89197535
72extracellular fibril organization (GO:0043206)2.87647763
73detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.87296873
74sulfur amino acid catabolic process (GO:0000098)2.86170724
75embryonic skeletal joint morphogenesis (GO:0060272)2.85733970
76negative regulation of chondrocyte differentiation (GO:0032331)2.82963111
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.82313142
78NADH dehydrogenase complex assembly (GO:0010257)2.82313142
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82313142
80DNA damage response, signal transduction resulting in transcription (GO:0042772)2.81071748
81type B pancreatic cell proliferation (GO:0044342)2.80763206
82striated muscle adaptation (GO:0014888)2.80441012
83neuroblast proliferation (GO:0007405)2.79208724
84neuron fate commitment (GO:0048663)2.77751666
85actin filament depolymerization (GO:0030042)2.76051707
86mesenchymal cell proliferation (GO:0010463)2.75419024
87mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.75273938
88regulation of gene expression by genetic imprinting (GO:0006349)2.73869885
89protein deneddylation (GO:0000338)2.72950642
90mechanosensory behavior (GO:0007638)2.71750936
91nucleotide salvage (GO:0043173)2.70856965
92dendritic spine morphogenesis (GO:0060997)2.69700185
93glandular epithelial cell differentiation (GO:0002067)2.69629587
94embryonic cranial skeleton morphogenesis (GO:0048701)2.69447548
95response to food (GO:0032094)2.69286321
96nucleoside transmembrane transport (GO:1901642)2.67334780
97negative regulation of DNA biosynthetic process (GO:2000279)2.67186195
98negative regulation of JAK-STAT cascade (GO:0046426)2.66816333
99mitotic nuclear envelope reassembly (GO:0007084)2.65081313
100nuclear envelope reassembly (GO:0031468)2.65081313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.64198202
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.49208541
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.43171388
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97675293
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82053873
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.63597834
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.61591828
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.61591828
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.61591828
10VDR_22108803_ChIP-Seq_LS180_Human2.58976754
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53058057
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.51665379
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47079755
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.45848884
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38060049
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.32365974
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26489448
18TP53_20018659_ChIP-ChIP_R1E_Mouse2.22791925
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.13080419
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01729007
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91955382
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86502446
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.80953740
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80913260
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80913260
26EZH2_22144423_ChIP-Seq_EOC_Human1.77882231
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77737392
28ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77067285
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70404721
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64055525
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.63210527
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62499081
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61830085
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61061514
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59801614
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59712456
37LXR_22292898_ChIP-Seq_THP-1_Human1.59527660
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.56704790
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54589067
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49989610
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49680027
42BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47324708
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45440548
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45028103
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44367866
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43399362
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.40846427
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.39447834
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38643584
50TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38442984
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36958537
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36500171
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35688915
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35103210
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30304474
56CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28650115
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.28492662
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27373461
59P68_20966046_ChIP-Seq_HELA_Human1.24846888
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.24211607
61XRN2_22483619_ChIP-Seq_HELA_Human1.22676171
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20962704
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16077469
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13854002
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10612423
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.07861869
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05423446
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05146723
69REST_21632747_ChIP-Seq_MESCs_Mouse1.03182009
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02220618
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01493333
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00379629
73SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99571427
74BCOR_27268052_Chip-Seq_Bcells_Human0.99308897
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97767603
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97192658
77MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96266540
78CIITA_25753668_ChIP-Seq_RAJI_Human0.96063180
79SOX17_20123909_ChIP-Seq_XEN_Mouse0.95626265
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94021203
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93847075
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93646061
83CBP_21632823_ChIP-Seq_H3396_Human0.93273475
84EZH2_27294783_Chip-Seq_ESCs_Mouse0.93210185
85EOMES_21245162_ChIP-Seq_HESCs_Human0.93126707
86TP53_22127205_ChIP-Seq_IMR90_Human0.92782452
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.92651144
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91891519
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91743044
90CTCF_27219007_Chip-Seq_Bcells_Human0.91138183
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90638527
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90313752
93ETS1_20019798_ChIP-Seq_JURKAT_Human0.89729151
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89302160
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88723201
96GABP_17652178_ChIP-ChIP_JURKAT_Human0.88461922
97TP53_23651856_ChIP-Seq_MEFs_Mouse0.86280206
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86095734
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85657247
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85368893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.43251877
2MP0003705_abnormal_hypodermis_morpholog4.40234480
3MP0005670_abnormal_white_adipose3.77623997
4MP0000747_muscle_weakness3.45285500
5MP0008789_abnormal_olfactory_epithelium2.86795335
6MP0000751_myopathy2.78278699
7MP0000749_muscle_degeneration2.77982467
8MP0004270_analgesia2.46718306
9MP0002095_abnormal_skin_pigmentation2.39829040
10MP0000013_abnormal_adipose_tissue2.32599281
11MP0005646_abnormal_pituitary_gland2.31709570
12MP0000759_abnormal_skeletal_muscle2.26886939
13MP0005083_abnormal_biliary_tract2.24860310
14MP0002089_abnormal_postnatal_growth/wei2.22849016
15MP0010030_abnormal_orbit_morphology2.15984394
16MP0000750_abnormal_muscle_regeneration2.09438237
17MP0006072_abnormal_retinal_apoptosis2.05587641
18MP0004145_abnormal_muscle_electrophysio2.05033089
19MP0003123_paternal_imprinting1.95639944
20MP0001968_abnormal_touch/_nociception1.91666028
21MP0005394_taste/olfaction_phenotype1.85571923
22MP0005499_abnormal_olfactory_system1.85571923
23MP0002736_abnormal_nociception_after1.83019855
24MP0005423_abnormal_somatic_nervous1.79165507
25MP0001502_abnormal_circadian_rhythm1.65712282
26MP0005257_abnormal_intraocular_pressure1.65158823
27MP0002269_muscular_atrophy1.64692379
28MP0004885_abnormal_endolymph1.64260928
29MP0000534_abnormal_ureter_morphology1.62792847
30MP0009780_abnormal_chondrocyte_physiolo1.60300941
31MP0000566_synostosis1.57118540
32MP0000049_abnormal_middle_ear1.54433250
33MP0002735_abnormal_chemical_nociception1.53304270
34MP0002734_abnormal_mechanical_nocicepti1.51660351
35MP0000003_abnormal_adipose_tissue1.50218932
36MP0009745_abnormal_behavioral_response1.46911218
37MP0004036_abnormal_muscle_relaxation1.46786905
38MP0001905_abnormal_dopamine_level1.41492964
39MP0003942_abnormal_urinary_system1.40385117
40MP0000516_abnormal_urinary_system1.38904738
41MP0005367_renal/urinary_system_phenotyp1.38904738
42MP0004087_abnormal_muscle_fiber1.37381985
43MP0004147_increased_porphyrin_level1.36710989
44MP0002332_abnormal_exercise_endurance1.35909052
45MP0002106_abnormal_muscle_physiology1.33785070
46MP0008775_abnormal_heart_ventricle1.30263553
47MP0003191_abnormal_cellular_cholesterol1.20439741
48MP0000537_abnormal_urethra_morphology1.19999154
49MP0002733_abnormal_thermal_nociception1.19916862
50MP0001529_abnormal_vocalization1.18716350
51MP0005360_urolithiasis1.16823377
52MP0003786_premature_aging1.15590821
53MP0000631_abnormal_neuroendocrine_gland1.12430796
54MP0003635_abnormal_synaptic_transmissio1.11263743
55MP0005620_abnormal_muscle_contractility1.10300202
56MP0006276_abnormal_autonomic_nervous1.09197108
57MP0005369_muscle_phenotype1.07005402
58MP0002108_abnormal_muscle_morphology1.05342352
59MP0008995_early_reproductive_senescence1.04848045
60MP0001440_abnormal_grooming_behavior1.04832797
61MP0000733_abnormal_muscle_development1.03378979
62MP0000778_abnormal_nervous_system1.03236376
63MP0002896_abnormal_bone_mineralization1.00733328
64MP0004811_abnormal_neuron_physiology0.99112047
65MP0002184_abnormal_innervation0.98859473
66MP0003959_abnormal_lean_body0.96140000
67MP0002064_seizures0.92629747
68MP0002069_abnormal_eating/drinking_beha0.90638348
69MP0001299_abnormal_eye_distance/0.88765869
70MP0009250_abnormal_appendicular_skeleto0.88428244
71MP0001340_abnormal_eyelid_morphology0.86660700
72MP0002572_abnormal_emotion/affect_behav0.83726319
73MP0001542_abnormal_bone_strength0.83633439
74MP0002063_abnormal_learning/memory/cond0.83432168
75MP0004142_abnormal_muscle_tone0.81164111
76MP0002138_abnormal_hepatobiliary_system0.81099408
77MP0001970_abnormal_pain_threshold0.80948076
78MP0000955_abnormal_spinal_cord0.80882338
79MP0004924_abnormal_behavior0.79764759
80MP0005386_behavior/neurological_phenoty0.79764759
81MP0002177_abnormal_outer_ear0.79477039
82MP0003045_fibrosis0.79127627
83MP0004133_heterotaxia0.75950677
84MP0004510_myositis0.74479124
85MP0002066_abnormal_motor_capabilities/c0.73920243
86MP0000163_abnormal_cartilage_morphology0.73274744
87MP0000647_abnormal_sebaceous_gland0.73158854
88MP0003806_abnormal_nucleotide_metabolis0.72620684
89MP0001243_abnormal_dermal_layer0.72084905
90MP0001486_abnormal_startle_reflex0.71203931
91MP0003755_abnormal_palate_morphology0.70960313
92MP0002282_abnormal_trachea_morphology0.70826060
93MP0009046_muscle_twitch0.69800555
94MP0005375_adipose_tissue_phenotype0.69671782
95MP0003638_abnormal_response/metabolism_0.66826926
96MP0002067_abnormal_sensory_capabilities0.66653833
97MP0002882_abnormal_neuron_morphology0.64307740
98MP0002272_abnormal_nervous_system0.63371260
99MP0001270_distended_abdomen0.62958585
100MP0005084_abnormal_gallbladder_morpholo0.62931103

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)5.67516724
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.24033444
3Abnormality of alanine metabolism (HP:0010916)5.24033444
4Hyperalaninemia (HP:0003348)5.24033444
5Reduced subcutaneous adipose tissue (HP:0003758)5.23824436
6Action tremor (HP:0002345)4.73872093
7Mask-like facies (HP:0000298)4.26351379
8Exercise-induced myalgia (HP:0003738)4.10452167
9Myopathic facies (HP:0002058)3.92730249
10Delayed CNS myelination (HP:0002188)3.69076640
11Nemaline bodies (HP:0003798)3.67312646
12Oligomenorrhea (HP:0000876)3.55624215
13Decreased electroretinogram (ERG) amplitude (HP:0000654)3.12768408
14Congenital sensorineural hearing impairment (HP:0008527)3.07726196
15Calcaneovalgus deformity (HP:0001848)3.02538440
16Deformed tarsal bones (HP:0008119)2.98878473
17Hypoventilation (HP:0002791)2.93415917
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.90447336
19Muscle fiber inclusion bodies (HP:0100299)2.88926517
20Constricted visual fields (HP:0001133)2.87091384
21Distal arthrogryposis (HP:0005684)2.80335534
22Stenosis of the external auditory canal (HP:0000402)2.77170049
23Down-sloping shoulders (HP:0200021)2.71898606
24Hypoalphalipoproteinemia (HP:0003233)2.69092687
25Esophageal varix (HP:0002040)2.63838598
26Absent phalangeal crease (HP:0006109)2.63731414
27Periorbital edema (HP:0100539)2.63338083
28Round ear (HP:0100830)2.63037727
29Poor speech (HP:0002465)2.60419034
30Lower limb amyotrophy (HP:0007210)2.59663230
31Microglossia (HP:0000171)2.59030877
32Facial edema (HP:0000282)2.58279355
33Fatigue (HP:0012378)2.57304346
34Abnormality of the fetal cardiovascular system (HP:0010948)2.57038454
35Abnormal umbilical cord blood vessels (HP:0011403)2.57038454
36Single umbilical artery (HP:0001195)2.57038454
37Aplasia involving bones of the extremities (HP:0009825)2.56303972
38Aplasia involving bones of the upper limbs (HP:0009823)2.56303972
39Aplasia of the phalanges of the hand (HP:0009802)2.56303972
40Fibular aplasia (HP:0002990)2.46999733
41Myocardial infarction (HP:0001658)2.44105231
42Glucose intolerance (HP:0000833)2.40998612
43Supranuclear gaze palsy (HP:0000605)2.36893443
44Maternal diabetes (HP:0009800)2.36132975
45Toxemia of pregnancy (HP:0100603)2.34995927
46Ulnar deviation of the wrist (HP:0003049)2.33697312
47Insulin-resistant diabetes mellitus (HP:0000831)2.33485875
48Increased purine levels (HP:0004368)2.30600370
49Hyperuricemia (HP:0002149)2.30600370
50Absent speech (HP:0001344)2.29082048
51Heterochromia iridis (HP:0001100)2.27863613
52Shallow orbits (HP:0000586)2.27591739
53Hyperkalemia (HP:0002153)2.23156245
54Difficulty climbing stairs (HP:0003551)2.22701401
55Abnormality of the columella (HP:0009929)2.22071057
56Neoplasm of the heart (HP:0100544)2.20516347
57Ankle clonus (HP:0011448)2.19588225
58Bell-shaped thorax (HP:0001591)2.19078553
59White forelock (HP:0002211)2.17544548
60Abnormal finger flexion creases (HP:0006143)2.11009067
61Distal lower limb amyotrophy (HP:0008944)2.08862724
62Amyloidosis (HP:0011034)2.08715595
63Abnormality of the umbilical cord (HP:0010881)2.06276120
64Abnormality of the phalanges of the 2nd finger (HP:0009541)2.05964141
65Abnormality of the sella turcica (HP:0002679)2.04601632
66Conjugated hyperbilirubinemia (HP:0002908)2.02122753
67Abnormality of the middle phalanges of the toes (HP:0010183)2.00866684
68Broad metatarsal (HP:0001783)1.95829035
69Increased serum pyruvate (HP:0003542)1.95610681
70Increased connective tissue (HP:0009025)1.95571330
71Adrenal hypoplasia (HP:0000835)1.94755172
72Insulin resistance (HP:0000855)1.94237715
73Synostosis involving the elbow (HP:0003938)1.93689349
74Humeroradial synostosis (HP:0003041)1.93689349
75Patchy hypopigmentation of hair (HP:0011365)1.93552344
76Obstructive sleep apnea (HP:0002870)1.92736913
77Hepatocellular necrosis (HP:0001404)1.91965203
78Decreased subcutaneous fat (HP:0001002)1.91937930
79Bifid uvula (HP:0000193)1.91353879
80Acanthosis nigricans (HP:0000956)1.90882600
81Progressive cerebellar ataxia (HP:0002073)1.88794927
82Clonus (HP:0002169)1.88303462
83Exercise-induced muscle cramps (HP:0003710)1.83890522
84Multiple lipomas (HP:0001012)1.83476271
85Muscle stiffness (HP:0003552)1.83299186
86Postural tremor (HP:0002174)1.83069402
87Myotonia (HP:0002486)1.82330090
88Abnormality of the proximal phalanges of the hand (HP:0009834)1.81949257
89Anxiety (HP:0000739)1.80733673
90Cholecystitis (HP:0001082)1.76192201
91Abnormal gallbladder physiology (HP:0012438)1.76192201
92Ileus (HP:0002595)1.72222886
93Myoglobinuria (HP:0002913)1.72029654
94Abnormality of glycolysis (HP:0004366)1.71979473
95Hyperphosphatemia (HP:0002905)1.70861175
96Abnormality of the parietal bone (HP:0002696)1.70853686
97Epileptic encephalopathy (HP:0200134)1.70783737
982-3 toe syndactyly (HP:0004691)1.69168771
99Nonprogressive disorder (HP:0003680)1.65654422
100Myokymia (HP:0002411)1.65464508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.59051807
2TESK14.58349638
3PHKG24.20694061
4PHKG14.20694061
5LIMK13.88413194
6NME23.33145803
7LMTK23.17904097
8VRK23.09761775
9MOS2.13113319
10EPHB21.83046803
11PAK61.74769647
12SGK2231.63938149
13SGK4941.63938149
14MAP3K121.63507731
15CCNB11.55998129
16MARK11.54380684
17CSNK1G21.53359387
18CDK91.43923585
19AURKA1.42568605
20MAP3K31.39476327
21CASK1.37725927
22MAP2K71.35576047
23CSNK1G31.30307062
24DAPK11.28473873
25CSNK1A1L1.27794320
26PRKD31.27123143
27NTRK21.27110425
28ARAF1.23822400
29FGFR21.22448447
30TAF11.22070493
31EPHA21.21068057
32BCKDK1.20718303
33MAP2K31.15435100
34PIM21.11463379
35DYRK21.11079355
36OBSCN1.09985457
37SGK21.04839837
38CSNK1G11.03258413
39ABL21.01469415
40MAP4K20.97893482
41NTRK30.97886224
42SGK30.96581808
43SCYL20.94837099
44ICK0.92814450
45HIPK20.89578351
46TIE10.81935902
47JAK30.81406100
48MAPKAPK30.81091320
49GRK70.80908128
50CAMKK20.77004878
51PAK40.76188814
52MINK10.75845356
53DAPK20.72010629
54CAMK2G0.71048898
55INSRR0.69719084
56ADRBK10.69011317
57MAP3K110.68673935
58MAPK130.63485241
59WNK10.62725379
60SRPK10.59750419
61RPS6KA20.55209446
62DYRK1B0.55098416
63CAMK1D0.54502670
64MST40.51788085
65NEK90.51546116
66PDK20.49053924
67MARK20.48230189
68CSNK1A10.47797914
69CDK50.47234666
70PRKCI0.47172242
71STK160.46903946
72VRK10.45049949
73PAK10.45049311
74TYRO30.44832909
75CAMK2D0.44083158
76CAMK1G0.41952635
77CHEK20.41412701
78STK380.40599165
79CDK140.38713752
80CDK150.38313216
81GRK50.37636129
82CDK11A0.37117654
83CDK180.36766302
84PRKCE0.35442398
85FGR0.33953103
86MUSK0.33328401
87CAMKK10.32866968
88NTRK10.31328038
89BRSK10.31248847
90FER0.30108658
91CDK190.28134877
92ERN10.27837210
93PTK20.26825411
94PRKD10.26062036
95ILK0.25447182
96CAMK10.25244577
97RPS6KA50.24987934
98KDR0.23526313
99ERBB20.21996790
100GSK3A0.21353103

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.27520295
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04478811
3Proteasome_Homo sapiens_hsa030503.02035268
4Galactose metabolism_Homo sapiens_hsa000522.44853872
5Salivary secretion_Homo sapiens_hsa049702.41217633
6Sulfur relay system_Homo sapiens_hsa041222.36974386
7Morphine addiction_Homo sapiens_hsa050322.35314475
8Tight junction_Homo sapiens_hsa045302.25380737
9GABAergic synapse_Homo sapiens_hsa047272.19005661
10Collecting duct acid secretion_Homo sapiens_hsa049662.16714431
11Vibrio cholerae infection_Homo sapiens_hsa051102.16561852
12Oxidative phosphorylation_Homo sapiens_hsa001902.12427641
13Regulation of autophagy_Homo sapiens_hsa041402.03235048
14Dopaminergic synapse_Homo sapiens_hsa047281.99757236
15Nicotine addiction_Homo sapiens_hsa050331.99439364
16Arginine biosynthesis_Homo sapiens_hsa002201.96810848
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90999098
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74425008
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69704381
20Alzheimers disease_Homo sapiens_hsa050101.69198809
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67942425
22Circadian entrainment_Homo sapiens_hsa047131.66495606
23Biosynthesis of amino acids_Homo sapiens_hsa012301.66029430
24Parkinsons disease_Homo sapiens_hsa050121.54191947
25Hedgehog signaling pathway_Homo sapiens_hsa043401.48695463
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46648748
27Glutathione metabolism_Homo sapiens_hsa004801.40984658
28Cardiac muscle contraction_Homo sapiens_hsa042601.38708868
29Huntingtons disease_Homo sapiens_hsa050161.35311023
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29818881
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.26633142
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23471165
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22542398
34Glutamatergic synapse_Homo sapiens_hsa047241.22292477
35Cholinergic synapse_Homo sapiens_hsa047251.11176511
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11137981
37Alcoholism_Homo sapiens_hsa050341.08799662
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.08443338
39Adherens junction_Homo sapiens_hsa045201.07335908
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06534222
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01808183
42Circadian rhythm_Homo sapiens_hsa047101.01361713
43Carbon metabolism_Homo sapiens_hsa012000.95466734
44Serotonergic synapse_Homo sapiens_hsa047260.92800794
45mRNA surveillance pathway_Homo sapiens_hsa030150.92653171
46Folate biosynthesis_Homo sapiens_hsa007900.92588581
47Cocaine addiction_Homo sapiens_hsa050300.91550642
48Spliceosome_Homo sapiens_hsa030400.91197906
49Oxytocin signaling pathway_Homo sapiens_hsa049210.90105242
50Renin secretion_Homo sapiens_hsa049240.86883405
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83146526
52Sulfur metabolism_Homo sapiens_hsa009200.83114363
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82380380
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80620543
55Gastric acid secretion_Homo sapiens_hsa049710.80010630
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78954573
57Wnt signaling pathway_Homo sapiens_hsa043100.78034626
58Axon guidance_Homo sapiens_hsa043600.76886437
59Endocytosis_Homo sapiens_hsa041440.76799754
60Pentose phosphate pathway_Homo sapiens_hsa000300.76410565
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76367452
62Insulin secretion_Homo sapiens_hsa049110.75965560
63Ribosome_Homo sapiens_hsa030100.74506520
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74376744
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73631212
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72051028
67Oocyte meiosis_Homo sapiens_hsa041140.71312502
68Amphetamine addiction_Homo sapiens_hsa050310.70990621
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70502942
70Basal cell carcinoma_Homo sapiens_hsa052170.70448911
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70329194
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68194720
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68074308
74Hippo signaling pathway_Homo sapiens_hsa043900.67201313
75Long-term depression_Homo sapiens_hsa047300.66600077
76Glucagon signaling pathway_Homo sapiens_hsa049220.63615166
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62747735
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61691500
79RNA polymerase_Homo sapiens_hsa030200.55399671
80Fatty acid elongation_Homo sapiens_hsa000620.55147127
81Estrogen signaling pathway_Homo sapiens_hsa049150.51973836
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51686782
83Calcium signaling pathway_Homo sapiens_hsa040200.49563950
84Dilated cardiomyopathy_Homo sapiens_hsa054140.49322973
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.47406564
86Fructose and mannose metabolism_Homo sapiens_hsa000510.47058324
87Gap junction_Homo sapiens_hsa045400.46808205
88Long-term potentiation_Homo sapiens_hsa047200.46536259
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45208859
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44809956
91Taste transduction_Homo sapiens_hsa047420.44540295
92Rheumatoid arthritis_Homo sapiens_hsa053230.43976244
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.41954127
94AMPK signaling pathway_Homo sapiens_hsa041520.41942150
95GnRH signaling pathway_Homo sapiens_hsa049120.39962901
96Nitrogen metabolism_Homo sapiens_hsa009100.39129842
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38305507
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38183998
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37493317
100Viral myocarditis_Homo sapiens_hsa054160.32929260

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