COX5BP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1base-excision repair, AP site formation (GO:0006285)6.20968335
2estrogen biosynthetic process (GO:0006703)5.57185460
3protein polyglutamylation (GO:0018095)5.43604625
4negative regulation of synaptic transmission, GABAergic (GO:0032229)4.89519957
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.80605391
6axoneme assembly (GO:0035082)4.69516271
7regulation of cilium movement (GO:0003352)4.49998438
8regulation of glutamate secretion (GO:0014048)4.34026899
9ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043164.22983848
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.22848526
11negative regulation of sodium ion transport (GO:0010766)4.18920965
12pyrimidine nucleotide catabolic process (GO:0006244)4.16593546
13nonmotile primary cilium assembly (GO:0035058)4.15093892
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.07017823
15cullin deneddylation (GO:0010388)4.05092294
16protein deneddylation (GO:0000338)3.98619196
17pyrimidine nucleobase catabolic process (GO:0006208)3.96498965
18oligosaccharide biosynthetic process (GO:0009312)3.93403891
19response to pheromone (GO:0019236)3.93173978
20platelet dense granule organization (GO:0060155)3.92609882
21negative regulation of amino acid transport (GO:0051956)3.91035412
22negative regulation of potassium ion transmembrane transport (GO:1901380)3.70437393
23melanosome transport (GO:0032402)3.62253223
24secondary metabolite biosynthetic process (GO:0044550)3.58138955
25behavioral response to nicotine (GO:0035095)3.53692479
26establishment of melanosome localization (GO:0032401)3.49738513
27behavioral response to ethanol (GO:0048149)3.46703024
28inositol phosphate catabolic process (GO:0071545)3.46661167
29pigment granule transport (GO:0051904)3.43066940
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36233901
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36233901
32establishment of pigment granule localization (GO:0051905)3.31930533
33phosphorylated carbohydrate dephosphorylation (GO:0046838)3.29992050
34inositol phosphate dephosphorylation (GO:0046855)3.29992050
35negative regulation of appetite (GO:0032099)3.25955883
36negative regulation of response to food (GO:0032096)3.25955883
37negative regulation of systemic arterial blood pressure (GO:0003085)3.25151608
38melanosome localization (GO:0032400)3.23412220
39photoreceptor cell maintenance (GO:0045494)3.21103033
40ubiquinone metabolic process (GO:0006743)3.19160997
41GPI anchor metabolic process (GO:0006505)3.19152266
42regulation of amino acid transport (GO:0051955)3.18538088
43pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.18055804
44nucleobase catabolic process (GO:0046113)3.16301598
45ubiquinone biosynthetic process (GO:0006744)3.13777665
46melanin biosynthetic process (GO:0042438)3.13483055
47piRNA metabolic process (GO:0034587)3.12880423
48pigment granule localization (GO:0051875)3.08081931
49GPI anchor biosynthetic process (GO:0006506)3.06989663
50DNA demethylation (GO:0080111)3.06436373
51cellular response to leptin stimulus (GO:0044320)3.02545109
52organelle disassembly (GO:1903008)3.01301044
53C4-dicarboxylate transport (GO:0015740)2.98150096
54DNA double-strand break processing (GO:0000729)2.97849683
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97578724
56positive regulation of mitochondrial fission (GO:0090141)2.94071407
57quinone metabolic process (GO:1901661)2.91312699
58retinal rod cell development (GO:0046548)2.89450138
59nucleotide transmembrane transport (GO:1901679)2.86779292
60L-methionine biosynthetic process (GO:0071265)2.81251701
61amino acid salvage (GO:0043102)2.81251701
62L-methionine salvage (GO:0071267)2.81251701
63regulation of microtubule-based movement (GO:0060632)2.77791674
64glycolipid biosynthetic process (GO:0009247)2.76679257
65auditory receptor cell stereocilium organization (GO:0060088)2.76132803
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71174631
67DNA dealkylation (GO:0035510)2.69362400
68microtubule bundle formation (GO:0001578)2.67912691
69brain morphogenesis (GO:0048854)2.64917585
70epithelial cilium movement (GO:0003351)2.63992880
71negative regulation of neurological system process (GO:0031645)2.63984962
72melanin metabolic process (GO:0006582)2.63596796
73meiotic chromosome segregation (GO:0045132)2.63144302
74ribonucleoprotein complex disassembly (GO:0032988)2.62459093
75cilium organization (GO:0044782)2.62113797
76establishment of mitochondrion localization (GO:0051654)2.61256225
77magnesium ion transport (GO:0015693)2.61056432
78cilium assembly (GO:0042384)2.60616631
79forebrain morphogenesis (GO:0048853)2.60515025
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.58698585
81GTP biosynthetic process (GO:0006183)2.57243235
82transmission of nerve impulse (GO:0019226)2.55282290
83deoxyribonucleotide catabolic process (GO:0009264)2.51844810
84quinone biosynthetic process (GO:1901663)2.51493971
85L-fucose catabolic process (GO:0042355)2.51037948
86fucose catabolic process (GO:0019317)2.51037948
87L-fucose metabolic process (GO:0042354)2.51037948
88negative regulation of telomere maintenance (GO:0032205)2.50264749
89ketone biosynthetic process (GO:0042181)2.48563973
90protein localization to cilium (GO:0061512)2.48561580
91intraciliary transport (GO:0042073)2.47753763
92sequestering of actin monomers (GO:0042989)2.47708254
93short-chain fatty acid metabolic process (GO:0046459)2.47648493
94short-term memory (GO:0007614)2.46644291
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46348392
96glycosphingolipid biosynthetic process (GO:0006688)2.46140009
97branched-chain amino acid catabolic process (GO:0009083)2.45489743
98regulation of DNA endoreduplication (GO:0032875)2.45255472
99vesicle localization (GO:0051648)2.43289684
100regulation of potassium ion transmembrane transporter activity (GO:1901016)2.40341373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.04174740
2VDR_22108803_ChIP-Seq_LS180_Human3.68308266
3ZNF274_21170338_ChIP-Seq_K562_Hela3.31298804
4GBX2_23144817_ChIP-Seq_PC3_Human2.88039342
5IGF1R_20145208_ChIP-Seq_DFB_Human2.74334650
6FUS_26573619_Chip-Seq_HEK293_Human2.74114067
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60371591
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60044203
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52813971
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52697269
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49680354
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44679392
13EZH2_22144423_ChIP-Seq_EOC_Human2.43653577
14TAF15_26573619_Chip-Seq_HEK293_Human2.16877280
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13155635
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.03527681
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01164314
18EWS_26573619_Chip-Seq_HEK293_Human1.96098785
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94621490
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91313233
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.91265155
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87663473
23ER_23166858_ChIP-Seq_MCF-7_Human1.86376720
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85939465
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78700049
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78527853
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.72340619
28CBP_20019798_ChIP-Seq_JUKART_Human1.70848926
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70848926
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.69400239
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67410914
32P300_19829295_ChIP-Seq_ESCs_Human1.63298004
33ELK1_19687146_ChIP-ChIP_HELA_Human1.60542859
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.58468699
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53496020
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51596135
37VDR_23849224_ChIP-Seq_CD4+_Human1.51425152
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51410230
39IRF1_19129219_ChIP-ChIP_H3396_Human1.47199955
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45453210
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44553957
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41489129
43TP53_22573176_ChIP-Seq_HFKS_Human1.36705123
44MYC_18940864_ChIP-ChIP_HL60_Human1.35835424
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.35763016
46RNF2_27304074_Chip-Seq_NSC_Mouse1.33456512
47SMAD4_21799915_ChIP-Seq_A2780_Human1.31785589
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29481233
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29355251
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29219466
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27950060
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27078318
53TAL1_26923725_Chip-Seq_HPCs_Mouse1.26450511
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25377663
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25048439
56FOXP3_21729870_ChIP-Seq_TREG_Human1.24793775
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.24303312
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23697372
59REST_21632747_ChIP-Seq_MESCs_Mouse1.23279364
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21875932
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.21469906
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20183868
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19195740
64NCOR_22424771_ChIP-Seq_293T_Human1.17398314
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.17246016
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15624524
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14964494
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.14856848
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13947637
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13013055
71BCAT_22108803_ChIP-Seq_LS180_Human1.10454288
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09952217
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.09952217
74NANOG_19829295_ChIP-Seq_ESCs_Human1.09580152
75SOX2_19829295_ChIP-Seq_ESCs_Human1.09580152
76TCF4_23295773_ChIP-Seq_U87_Human1.08819128
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06391083
78AR_25329375_ChIP-Seq_VCAP_Human1.06303377
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05668141
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05136993
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04944837
82PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04870511
83TCF4_22108803_ChIP-Seq_LS180_Human1.02859926
84JUN_21703547_ChIP-Seq_K562_Human1.02454184
85RUNX2_22187159_ChIP-Seq_PCA_Human1.02326402
86AR_20517297_ChIP-Seq_VCAP_Human1.02119003
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00997093
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00478710
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.98581419
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98057297
91YY1_21170310_ChIP-Seq_MESCs_Mouse0.97723637
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.97393882
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95707648
94STAT3_23295773_ChIP-Seq_U87_Human0.94120612
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.94062597
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93549070
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93486117
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92275630
99CIITA_25753668_ChIP-Seq_RAJI_Human0.90806083
100MYC_19829295_ChIP-Seq_ESCs_Human0.88500959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.32759284
2MP0000372_irregular_coat_pigmentation3.14934398
3MP0008877_abnormal_DNA_methylation3.08894017
4MP0001529_abnormal_vocalization2.99976947
5MP0001984_abnormal_olfaction2.96284095
6MP0001968_abnormal_touch/_nociception2.95786020
7MP0006292_abnormal_olfactory_placode2.91862461
8MP0008789_abnormal_olfactory_epithelium2.80010191
9MP0005499_abnormal_olfactory_system2.58598184
10MP0005394_taste/olfaction_phenotype2.58598184
11MP0005645_abnormal_hypothalamus_physiol2.55804950
12MP0003880_abnormal_central_pattern2.48741339
13MP0005551_abnormal_eye_electrophysiolog2.38668977
14MP0005084_abnormal_gallbladder_morpholo2.33323212
15MP0006276_abnormal_autonomic_nervous2.21669215
16MP0005646_abnormal_pituitary_gland2.15792023
17MP0003122_maternal_imprinting2.13530410
18MP0001986_abnormal_taste_sensitivity2.12428673
19MP0003121_genomic_imprinting2.09878700
20MP0002638_abnormal_pupillary_reflex2.09586271
21MP0005423_abnormal_somatic_nervous1.96368313
22MP0005253_abnormal_eye_physiology1.95332195
23MP0002102_abnormal_ear_morphology1.93988383
24MP0005075_abnormal_melanosome_morpholog1.81887623
25MP0002272_abnormal_nervous_system1.73476070
26MP0002653_abnormal_ependyma_morphology1.65501420
27MP0001324_abnormal_eye_pigmentation1.65456130
28MP0002735_abnormal_chemical_nociception1.64991229
29MP0002736_abnormal_nociception_after1.64642648
30MP0002733_abnormal_thermal_nociception1.61942965
31MP0002822_catalepsy1.61488268
32MP0002837_dystrophic_cardiac_calcinosis1.59462600
33MP0000465_gastrointestinal_hemorrhage1.58219681
34MP0009046_muscle_twitch1.57860197
35MP0001486_abnormal_startle_reflex1.54344103
36MP0004147_increased_porphyrin_level1.49823126
37MP0009745_abnormal_behavioral_response1.48984171
38MP0004142_abnormal_muscle_tone1.47583037
39MP0002160_abnormal_reproductive_system1.47228625
40MP0004885_abnormal_endolymph1.43832888
41MP0002234_abnormal_pharynx_morphology1.43003408
42MP0006072_abnormal_retinal_apoptosis1.41457168
43MP0003567_abnormal_fetal_cardiomyocyte1.38778375
44MP0003718_maternal_effect1.37767947
45MP0004924_abnormal_behavior1.35986770
46MP0005386_behavior/neurological_phenoty1.35986770
47MP0008872_abnormal_physiological_respon1.35439445
48MP0000631_abnormal_neuroendocrine_gland1.34306681
49MP0005389_reproductive_system_phenotype1.33278520
50MP0000015_abnormal_ear_pigmentation1.31749605
51MP0001970_abnormal_pain_threshold1.30238637
52MP0002557_abnormal_social/conspecific_i1.28494304
53MP0001764_abnormal_homeostasis1.26793167
54MP0002572_abnormal_emotion/affect_behav1.24065024
55MP0003635_abnormal_synaptic_transmissio1.23244233
56MP0001293_anophthalmia1.21992871
57MP0008058_abnormal_DNA_repair1.20350077
58MP0002095_abnormal_skin_pigmentation1.18033499
59MP0002090_abnormal_vision1.16139502
60MP0005195_abnormal_posterior_eye1.14750984
61MP0003646_muscle_fatigue1.12661530
62MP0002734_abnormal_mechanical_nocicepti1.12296727
63MP0002876_abnormal_thyroid_physiology1.10870453
64MP0002752_abnormal_somatic_nervous1.08828457
65MP0002063_abnormal_learning/memory/cond1.07604286
66MP0008995_early_reproductive_senescence1.06902773
67MP0005670_abnormal_white_adipose1.05247051
68MP0004859_abnormal_synaptic_plasticity1.04013066
69MP0003136_yellow_coat_color1.03699104
70MP0001664_abnormal_digestion1.03421681
71MP0001905_abnormal_dopamine_level1.03097143
72MP0005391_vision/eye_phenotype0.97251466
73MP0005167_abnormal_blood-brain_barrier0.96329701
74MP0001501_abnormal_sleep_pattern0.94885529
75MP0004043_abnormal_pH_regulation0.94243423
76MP0005397_hematopoietic_system_phenotyp0.92043999
77MP0001545_abnormal_hematopoietic_system0.92043999
78MP0002067_abnormal_sensory_capabilities0.91729278
79MP0000778_abnormal_nervous_system0.90271490
80MP0001963_abnormal_hearing_physiology0.89308912
81MP0002064_seizures0.88919419
82MP0003698_abnormal_male_reproductive0.88193130
83MP0003195_calcinosis0.87672529
84MP0010094_abnormal_chromosome_stability0.86477738
85MP0001929_abnormal_gametogenesis0.84966293
86MP0000427_abnormal_hair_cycle0.84535042
87MP0002938_white_spotting0.84310722
88MP0004145_abnormal_muscle_electrophysio0.83529281
89MP0008875_abnormal_xenobiotic_pharmacok0.82804044
90MP0005410_abnormal_fertilization0.82155313
91MP0001919_abnormal_reproductive_system0.81194417
92MP0002882_abnormal_neuron_morphology0.75180690
93MP0002184_abnormal_innervation0.73526988
94MP0000026_abnormal_inner_ear0.72924791
95MP0005367_renal/urinary_system_phenotyp0.71951121
96MP0000516_abnormal_urinary_system0.71951121
97MP0005408_hypopigmentation0.71760738
98MP0000653_abnormal_sex_gland0.68308207
99MP0004811_abnormal_neuron_physiology0.68065288
100MP0003890_abnormal_embryonic-extraembry0.64052539

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)4.31062194
2Congenital stationary night blindness (HP:0007642)4.23839277
3Medial flaring of the eyebrow (HP:0010747)4.15584539
4Decreased central vision (HP:0007663)4.01194866
5Gait imbalance (HP:0002141)3.87430146
6Dyschromatopsia (HP:0007641)3.86498274
7Congenital primary aphakia (HP:0007707)3.79743276
8Reduced antithrombin III activity (HP:0001976)3.76334072
9Nephrogenic diabetes insipidus (HP:0009806)3.62262165
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.23432896
11Abnormal protein N-linked glycosylation (HP:0012347)3.23432896
12Abnormal protein glycosylation (HP:0012346)3.23432896
13Abnormal glycosylation (HP:0012345)3.23432896
14Facial hemangioma (HP:0000329)3.18717866
15Chronic hepatic failure (HP:0100626)3.06850536
16Central scotoma (HP:0000603)3.03303442
17Abolished electroretinogram (ERG) (HP:0000550)2.97047038
18Genital tract atresia (HP:0001827)2.78273094
19Vaginal atresia (HP:0000148)2.76789239
20Abnormality of midbrain morphology (HP:0002418)2.76484185
21Molar tooth sign on MRI (HP:0002419)2.76484185
22Pancreatic cysts (HP:0001737)2.73102851
23Retinal dysplasia (HP:0007973)2.71944600
24Abnormal rod and cone electroretinograms (HP:0008323)2.69728964
25Acute encephalopathy (HP:0006846)2.60579104
26Polyphagia (HP:0002591)2.58306992
27True hermaphroditism (HP:0010459)2.57193252
28Acute necrotizing encephalopathy (HP:0006965)2.54375100
29Hyperglycinemia (HP:0002154)2.49541446
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47273568
31Protruding tongue (HP:0010808)2.47008239
32Generalized hypopigmentation (HP:0007513)2.46428793
33Poor coordination (HP:0002370)2.45538359
34Nephronophthisis (HP:0000090)2.44914791
35Absent speech (HP:0001344)2.43996609
36Decreased testicular size (HP:0008734)2.41402133
37Attenuation of retinal blood vessels (HP:0007843)2.39659242
38Specific learning disability (HP:0001328)2.39152493
39Pancreatic fibrosis (HP:0100732)2.34689398
40Macular degeneration (HP:0000608)2.32122721
41Iris hypopigmentation (HP:0007730)2.31903321
42Volvulus (HP:0002580)2.28678141
43Abnormal mitochondria in muscle tissue (HP:0008316)2.28170414
44Capillary hemangiomas (HP:0005306)2.28137923
45Retinitis pigmentosa (HP:0000510)2.27752013
46Progressive macrocephaly (HP:0004481)2.26317283
47Thyroid-stimulating hormone excess (HP:0002925)2.25248492
48Failure to thrive in infancy (HP:0001531)2.24335029
49Colon cancer (HP:0003003)2.23332558
50Bony spicule pigmentary retinopathy (HP:0007737)2.23298830
513-Methylglutaconic aciduria (HP:0003535)2.20068543
52Type II lissencephaly (HP:0007260)2.19701324
53Albinism (HP:0001022)2.16211639
54Adactyly (HP:0009776)2.11646912
55Postaxial hand polydactyly (HP:0001162)2.11384867
56Abnormality of the renal cortex (HP:0011035)2.11344843
57Pachygyria (HP:0001302)2.10572478
58Pendular nystagmus (HP:0012043)2.09403850
59Abnormality of the renal medulla (HP:0100957)2.07123715
60Increased CSF lactate (HP:0002490)2.04173065
61Ocular albinism (HP:0001107)2.03909498
62Astigmatism (HP:0000483)2.03850542
63Ulnar claw (HP:0001178)2.03552936
64Abnormality of the labia minora (HP:0012880)2.01335409
65Lissencephaly (HP:0001339)2.01114266
66Dyskinesia (HP:0100660)1.99180166
67Broad foot (HP:0001769)1.99119377
68Microretrognathia (HP:0000308)1.98506382
69Renal cortical cysts (HP:0000803)1.97561862
70Vitreoretinal degeneration (HP:0000655)1.97550992
71Optic disc pallor (HP:0000543)1.94312133
72Thyroiditis (HP:0100646)1.94126863
73Mitochondrial inheritance (HP:0001427)1.92338165
74Congenital hepatic fibrosis (HP:0002612)1.91772527
75Hyperglycinuria (HP:0003108)1.88949165
76Generalized hypotonia (HP:0001290)1.87634400
77Occipital encephalocele (HP:0002085)1.83925881
78Aplasia/hypoplasia of the uterus (HP:0008684)1.82774353
79Growth hormone deficiency (HP:0000824)1.81073295
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81035117
81Amyotrophic lateral sclerosis (HP:0007354)1.80809683
82Abnormality of the columella (HP:0009929)1.80785775
83Aplasia/Hypoplasia of the macula (HP:0008059)1.80312176
84Limb dystonia (HP:0002451)1.77293414
85Photophobia (HP:0000613)1.77276479
86Hepatocellular necrosis (HP:0001404)1.76446344
87Aplasia/Hypoplasia of the lens (HP:0008063)1.76333596
88Hepatic necrosis (HP:0002605)1.76147455
89Amblyopia (HP:0000646)1.75841831
90Cheilitis (HP:0100825)1.74352334
91Narrow forehead (HP:0000341)1.74128571
92Tachypnea (HP:0002789)1.72437781
93Delayed CNS myelination (HP:0002188)1.70954331
94Self-mutilation (HP:0000742)1.70361573
95Left ventricular hypertrophy (HP:0001712)1.70208761
96Abnormality of glycine metabolism (HP:0010895)1.69673182
97Abnormality of serine family amino acid metabolism (HP:0010894)1.69673182
98Abnormality of the fovea (HP:0000493)1.69068897
99Postaxial foot polydactyly (HP:0001830)1.68193720
100Aplasia/Hypoplasia affecting the retina (HP:0008061)1.67390952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DAPK23.02491796
2BCR2.97234323
3TRIM282.85330652
4MAP2K72.83058751
5MAP3K42.54471054
6WNK32.49905292
7FRK2.38637804
8VRK22.29232321
9NUAK12.24595593
10MAPK132.18789302
11BMPR1B2.06315593
12DAPK11.90317912
13ERBB31.90113527
14TIE11.86727741
15CSNK1G31.75102017
16PLK21.72614089
17TXK1.68186233
18CDK191.63439176
19CSNK1G21.62906776
20MARK11.56538260
21TNIK1.53176616
22SIK31.52675281
23MKNK11.51628671
24BCKDK1.49672959
25ADRBK21.46695552
26DYRK21.45723954
27CSNK1A1L1.44016661
28CSNK1G11.42315777
29STK38L1.40754074
30MAP4K21.39574504
31SRPK11.33074253
32TAOK31.31643813
33PINK11.23172323
34VRK11.22865751
35UHMK11.22020204
36MARK31.18935962
37CAMKK21.17909022
38EIF2AK31.17415833
39PLK31.13776738
40MINK11.12297752
41WEE11.11758323
42GRK11.10451207
43EPHA31.09793878
44SIK21.09398090
45MKNK21.08592956
46FLT31.07440068
47MAP2K41.07390025
48PRKCG1.03248484
49GRK51.02308805
50INSRR0.98919186
51EPHA40.96740869
52BRSK20.89486294
53CASK0.82556729
54TAF10.80881211
55DYRK1B0.80769444
56NEK20.79976017
57ADRBK10.76636479
58EIF2AK20.74288735
59DYRK1A0.69752590
60CAMK2A0.68223740
61DYRK30.67574425
62ATR0.67180612
63CAMK2B0.66865079
64PLK40.63516809
65PRKCE0.63121611
66RPS6KA40.61025120
67KIT0.60488407
68MAPKAPK50.57048402
69PKN10.56502869
70KDR0.56502077
71PTK2B0.56472766
72NEK10.55156282
73DAPK30.54617446
74OXSR10.54614192
75CDK140.52942267
76ATM0.49378104
77STK110.48696761
78ACVR1B0.48649487
79TGFBR10.45682871
80ZAK0.43652238
81MAPK100.43057333
82NME10.42339800
83CSNK1D0.41927345
84PRKACA0.40546762
85PLK10.39313707
86PIM20.38373897
87GRK60.38073951
88TNK20.36982571
89CSNK2A10.36628325
90CDK60.36473915
91NTRK20.36260737
92WNK40.35634715
93PAK30.34888976
94CSNK1A10.33476219
95FER0.33460595
96MAPK40.30174852
97CDC70.30125633
98PHKG10.29810505
99PHKG20.29810505
100MAP3K50.28268601

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.39719233
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.38065394
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69283764
4Fatty acid elongation_Homo sapiens_hsa000622.49931684
5Butanoate metabolism_Homo sapiens_hsa006502.40681938
6Protein export_Homo sapiens_hsa030602.40393983
7Propanoate metabolism_Homo sapiens_hsa006402.17405676
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14363292
9Base excision repair_Homo sapiens_hsa034102.13826876
10Phototransduction_Homo sapiens_hsa047442.12108092
11Nicotine addiction_Homo sapiens_hsa050332.11094406
12Homologous recombination_Homo sapiens_hsa034402.08837860
13Non-homologous end-joining_Homo sapiens_hsa034502.00954412
14Oxidative phosphorylation_Homo sapiens_hsa001901.90335380
15RNA polymerase_Homo sapiens_hsa030201.81309198
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68439702
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67911645
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.64418273
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63317516
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.62898062
21Parkinsons disease_Homo sapiens_hsa050121.54620483
22Fanconi anemia pathway_Homo sapiens_hsa034601.50303683
23Ether lipid metabolism_Homo sapiens_hsa005651.47729309
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46198393
25Nitrogen metabolism_Homo sapiens_hsa009101.44694472
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43943007
27Peroxisome_Homo sapiens_hsa041461.43821916
28Taste transduction_Homo sapiens_hsa047421.41399026
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41086962
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35584282
31Steroid biosynthesis_Homo sapiens_hsa001001.35430135
32Linoleic acid metabolism_Homo sapiens_hsa005911.24147075
33Collecting duct acid secretion_Homo sapiens_hsa049661.22174719
34Basal transcription factors_Homo sapiens_hsa030221.20306863
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20245477
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20163559
37Regulation of autophagy_Homo sapiens_hsa041401.19995539
38Fatty acid metabolism_Homo sapiens_hsa012121.16789103
39Morphine addiction_Homo sapiens_hsa050321.15482995
40RNA degradation_Homo sapiens_hsa030181.13825804
41Selenocompound metabolism_Homo sapiens_hsa004501.13016693
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11323477
43Pyrimidine metabolism_Homo sapiens_hsa002401.08647789
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07653152
45Olfactory transduction_Homo sapiens_hsa047401.05951855
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04194448
47GABAergic synapse_Homo sapiens_hsa047271.03908050
48Huntingtons disease_Homo sapiens_hsa050161.01524388
49Synaptic vesicle cycle_Homo sapiens_hsa047211.00914384
50Circadian entrainment_Homo sapiens_hsa047130.99194818
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95599101
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94977710
53Ovarian steroidogenesis_Homo sapiens_hsa049130.94520341
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93190366
55beta-Alanine metabolism_Homo sapiens_hsa004100.91806705
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91264764
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90761891
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.87552219
59Glutamatergic synapse_Homo sapiens_hsa047240.87349561
60Metabolic pathways_Homo sapiens_hsa011000.86354744
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85505612
62Pentose phosphate pathway_Homo sapiens_hsa000300.83863324
63Proteasome_Homo sapiens_hsa030500.83813372
64Chemical carcinogenesis_Homo sapiens_hsa052040.81552476
65Purine metabolism_Homo sapiens_hsa002300.81237772
66Arginine and proline metabolism_Homo sapiens_hsa003300.80049981
67N-Glycan biosynthesis_Homo sapiens_hsa005100.79689962
68Carbon metabolism_Homo sapiens_hsa012000.79176228
69Folate biosynthesis_Homo sapiens_hsa007900.71812220
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70613168
71Pyruvate metabolism_Homo sapiens_hsa006200.69011461
72Nucleotide excision repair_Homo sapiens_hsa034200.63523312
73Alzheimers disease_Homo sapiens_hsa050100.63098110
74Tyrosine metabolism_Homo sapiens_hsa003500.62521346
75Dopaminergic synapse_Homo sapiens_hsa047280.59510451
76Biosynthesis of amino acids_Homo sapiens_hsa012300.58471043
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.57399700
78Tryptophan metabolism_Homo sapiens_hsa003800.56017558
79Salivary secretion_Homo sapiens_hsa049700.54705674
80Spliceosome_Homo sapiens_hsa030400.54416712
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54370350
82RNA transport_Homo sapiens_hsa030130.53807760
83Arachidonic acid metabolism_Homo sapiens_hsa005900.52374205
84Fat digestion and absorption_Homo sapiens_hsa049750.52017866
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50855773
86Cocaine addiction_Homo sapiens_hsa050300.49091344
87Asthma_Homo sapiens_hsa053100.47333156
88Mismatch repair_Homo sapiens_hsa034300.46608776
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.44601513
90Oocyte meiosis_Homo sapiens_hsa041140.43086366
91Retinol metabolism_Homo sapiens_hsa008300.42370244
92Fatty acid degradation_Homo sapiens_hsa000710.42251759
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40218993
94Glutathione metabolism_Homo sapiens_hsa004800.38973807
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37260203
96Long-term depression_Homo sapiens_hsa047300.37203690
97ABC transporters_Homo sapiens_hsa020100.35883274
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35185028
99Cardiac muscle contraction_Homo sapiens_hsa042600.33697155
100Caffeine metabolism_Homo sapiens_hsa002320.33458257

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