

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.20842584 |
| 2 | DNA deamination (GO:0045006) | 5.74755336 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.40089712 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.30099057 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.30099057 |
| 6 | behavioral response to nicotine (GO:0035095) | 5.17311202 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.84238863 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 4.39758516 |
| 9 | ribosomal small subunit assembly (GO:0000028) | 4.25432534 |
| 10 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.25050649 |
| 11 | rRNA modification (GO:0000154) | 4.02511043 |
| 12 | positive regulation of prostaglandin secretion (GO:0032308) | 3.96923729 |
| 13 | protein complex biogenesis (GO:0070271) | 3.82626633 |
| 14 | respiratory electron transport chain (GO:0022904) | 3.70530764 |
| 15 | electron transport chain (GO:0022900) | 3.68769016 |
| 16 | DNA double-strand break processing (GO:0000729) | 3.66931810 |
| 17 | respiratory chain complex IV assembly (GO:0008535) | 3.61608421 |
| 18 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.61191436 |
| 19 | protein deneddylation (GO:0000338) | 3.60375801 |
| 20 | nucleoside diphosphate catabolic process (GO:0009134) | 3.59381465 |
| 21 | NADH metabolic process (GO:0006734) | 3.56301835 |
| 22 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.55616415 |
| 23 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.51902725 |
| 24 | protein neddylation (GO:0045116) | 3.49637407 |
| 25 | cytochrome complex assembly (GO:0017004) | 3.47224206 |
| 26 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.46216776 |
| 27 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.44075267 |
| 28 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.44075267 |
| 29 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.43637732 |
| 30 | response to pheromone (GO:0019236) | 3.43129928 |
| 31 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.41930737 |
| 32 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.41930737 |
| 33 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.41930737 |
| 34 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.38582327 |
| 35 | hydrogen ion transmembrane transport (GO:1902600) | 3.36406868 |
| 36 | regulation of prostaglandin secretion (GO:0032306) | 3.35026823 |
| 37 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.34290450 |
| 38 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.33866160 |
| 39 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.33866160 |
| 40 | NADH dehydrogenase complex assembly (GO:0010257) | 3.33866160 |
| 41 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.31922507 |
| 42 | positive regulation of fatty acid transport (GO:2000193) | 3.29183170 |
| 43 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.23835656 |
| 44 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.23835656 |
| 45 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.22740730 |
| 46 | cullin deneddylation (GO:0010388) | 3.21746967 |
| 47 | artery smooth muscle contraction (GO:0014824) | 3.18874552 |
| 48 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.17501409 |
| 49 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.15906887 |
| 50 | amino acid salvage (GO:0043102) | 3.15102699 |
| 51 | L-methionine salvage (GO:0071267) | 3.15102699 |
| 52 | L-methionine biosynthetic process (GO:0071265) | 3.15102699 |
| 53 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.14896739 |
| 54 | positive regulation of icosanoid secretion (GO:0032305) | 3.13491112 |
| 55 | negative regulation of macroautophagy (GO:0016242) | 3.13258176 |
| 56 | protein-cofactor linkage (GO:0018065) | 3.11790916 |
| 57 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.07072423 |
| 58 | regulation of mitochondrial translation (GO:0070129) | 3.04300001 |
| 59 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.03901349 |
| 60 | spliceosomal complex assembly (GO:0000245) | 3.03001961 |
| 61 | GTP biosynthetic process (GO:0006183) | 3.02923353 |
| 62 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.02704922 |
| 63 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.02674451 |
| 64 | ATP biosynthetic process (GO:0006754) | 3.02595850 |
| 65 | rRNA methylation (GO:0031167) | 2.99389729 |
| 66 | telomere maintenance via telomerase (GO:0007004) | 2.96400430 |
| 67 | proton transport (GO:0015992) | 2.94612417 |
| 68 | hydrogen transport (GO:0006818) | 2.94193757 |
| 69 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.93500302 |
| 70 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.92297832 |
| 71 | negative regulation of ligase activity (GO:0051352) | 2.92297832 |
| 72 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.90120984 |
| 73 | cytidine metabolic process (GO:0046087) | 2.89859782 |
| 74 | cytidine catabolic process (GO:0006216) | 2.89859782 |
| 75 | cytidine deamination (GO:0009972) | 2.89859782 |
| 76 | protein targeting to mitochondrion (GO:0006626) | 2.89529897 |
| 77 | protein K6-linked ubiquitination (GO:0085020) | 2.89288864 |
| 78 | DNA damage response, detection of DNA damage (GO:0042769) | 2.89195811 |
| 79 | peptidyl-histidine modification (GO:0018202) | 2.83981376 |
| 80 | regulation of cellular amine metabolic process (GO:0033238) | 2.82872719 |
| 81 | telomere maintenance via recombination (GO:0000722) | 2.82560867 |
| 82 | signal peptide processing (GO:0006465) | 2.82290647 |
| 83 | inner mitochondrial membrane organization (GO:0007007) | 2.82138165 |
| 84 | positive regulation of ligase activity (GO:0051351) | 2.79408189 |
| 85 | regulation of action potential (GO:0098900) | 2.77574506 |
| 86 | establishment of protein localization to mitochondrion (GO:0072655) | 2.74237902 |
| 87 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.73951907 |
| 88 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.73663693 |
| 89 | tonic smooth muscle contraction (GO:0014820) | 2.70041349 |
| 90 | arginine metabolic process (GO:0006525) | 2.69201649 |
| 91 | maturation of 5.8S rRNA (GO:0000460) | 2.69117278 |
| 92 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.68283436 |
| 93 | L-phenylalanine metabolic process (GO:0006558) | 2.68283436 |
| 94 | replication fork processing (GO:0031297) | 2.67613019 |
| 95 | L-ascorbic acid metabolic process (GO:0019852) | 2.67007972 |
| 96 | protein localization to mitochondrion (GO:0070585) | 2.66762494 |
| 97 | methionine biosynthetic process (GO:0009086) | 2.65868542 |
| 98 | positive regulation of cell cycle arrest (GO:0071158) | 2.65596947 |
| 99 | glyoxylate metabolic process (GO:0046487) | 2.64422629 |
| 100 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.63701190 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.25167033 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.23108118 |
| 3 | VDR_22108803_ChIP-Seq_LS180_Human | 4.08257628 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.06789497 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.64670737 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.33815350 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.26308721 |
| 8 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.02416335 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.98566202 |
| 10 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.92607848 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.79709189 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.67206073 |
| 13 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.58544333 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.36228297 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.27473687 |
| 16 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.24275340 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.21765467 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.16309590 |
| 19 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 2.13427470 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.11462947 |
| 21 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.11090103 |
| 22 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.07395186 |
| 23 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.04790985 |
| 24 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.88812122 |
| 25 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.88555078 |
| 26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.87867944 |
| 27 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.82290107 |
| 28 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.77055599 |
| 29 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.69213049 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.68970996 |
| 31 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.67122650 |
| 32 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.64723615 |
| 33 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.58351305 |
| 34 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.54323603 |
| 35 | AR_20517297_ChIP-Seq_VCAP_Human | 1.43714512 |
| 36 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.40545614 |
| 37 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.37680931 |
| 38 | NCOR_22424771_ChIP-Seq_293T_Human | 1.37265231 |
| 39 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.35911963 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.34746762 |
| 41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.32983969 |
| 42 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31326700 |
| 43 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.30272946 |
| 44 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.29738606 |
| 45 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.27688753 |
| 46 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.27582165 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.25698580 |
| 48 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.25660265 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.23848528 |
| 50 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.23485821 |
| 51 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.23330867 |
| 52 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.23330317 |
| 53 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.23330317 |
| 54 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.23293473 |
| 55 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22207088 |
| 56 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.21769746 |
| 57 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.19339623 |
| 58 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.17528336 |
| 59 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.16614675 |
| 60 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.16055092 |
| 61 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.15288645 |
| 62 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.15288645 |
| 63 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.15169807 |
| 64 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.14704986 |
| 65 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.13159950 |
| 66 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.09018370 |
| 67 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.08524883 |
| 68 | EWS_26573619_Chip-Seq_HEK293_Human | 1.07584415 |
| 69 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.06244383 |
| 70 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.05578508 |
| 71 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.05573753 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03823469 |
| 73 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.03622130 |
| 74 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.03018669 |
| 75 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.02958122 |
| 76 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.00742033 |
| 77 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.99288047 |
| 78 | P300_19829295_ChIP-Seq_ESCs_Human | 0.96838583 |
| 79 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.96151753 |
| 80 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.94277577 |
| 81 | ERA_21632823_ChIP-Seq_H3396_Human | 0.93929930 |
| 82 | GATA3_26560356_Chip-Seq_TH2_Human | 0.93167734 |
| 83 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93030242 |
| 84 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.92112789 |
| 85 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.91922297 |
| 86 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.91047427 |
| 87 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.84617857 |
| 88 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.83867514 |
| 89 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.83469114 |
| 90 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.83360518 |
| 91 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83155963 |
| 92 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.82650858 |
| 93 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.82554996 |
| 94 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.81773840 |
| 95 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.79988276 |
| 96 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.79268538 |
| 97 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.79026137 |
| 98 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.78121933 |
| 99 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.77386563 |
| 100 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.76976993 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 3.89300297 |
| 2 | MP0005360_urolithiasis | 3.86862476 |
| 3 | MP0005084_abnormal_gallbladder_morpholo | 3.71751461 |
| 4 | MP0002138_abnormal_hepatobiliary_system | 3.61435899 |
| 5 | MP0005085_abnormal_gallbladder_physiolo | 3.41321872 |
| 6 | MP0010386_abnormal_urinary_bladder | 3.32553620 |
| 7 | MP0004145_abnormal_muscle_electrophysio | 2.75917208 |
| 8 | MP0002102_abnormal_ear_morphology | 2.72633459 |
| 9 | MP0003195_calcinosis | 2.54681567 |
| 10 | MP0008875_abnormal_xenobiotic_pharmacok | 2.51264109 |
| 11 | MP0006036_abnormal_mitochondrial_physio | 2.43186597 |
| 12 | MP0008877_abnormal_DNA_methylation | 2.30747612 |
| 13 | MP0003786_premature_aging | 2.21766350 |
| 14 | MP0002160_abnormal_reproductive_system | 2.13902980 |
| 15 | MP0006276_abnormal_autonomic_nervous | 2.13823863 |
| 16 | MP0006035_abnormal_mitochondrial_morpho | 2.11851147 |
| 17 | MP0005083_abnormal_biliary_tract | 2.07669564 |
| 18 | MP0002139_abnormal_hepatobiliary_system | 2.06927160 |
| 19 | MP0008872_abnormal_physiological_respon | 2.05647609 |
| 20 | MP0005365_abnormal_bile_salt | 2.04044547 |
| 21 | MP0001986_abnormal_taste_sensitivity | 1.95548506 |
| 22 | MP0005389_reproductive_system_phenotype | 1.90396546 |
| 23 | MP0006072_abnormal_retinal_apoptosis | 1.89797989 |
| 24 | MP0010329_abnormal_lipoprotein_level | 1.82454409 |
| 25 | MP0006054_spinal_hemorrhage | 1.74814617 |
| 26 | MP0003186_abnormal_redox_activity | 1.68590569 |
| 27 | MP0001529_abnormal_vocalization | 1.65339727 |
| 28 | MP0003646_muscle_fatigue | 1.61057529 |
| 29 | MP0009697_abnormal_copulation | 1.59680267 |
| 30 | MP0002837_dystrophic_cardiac_calcinosis | 1.59510429 |
| 31 | MP0003252_abnormal_bile_duct | 1.56312890 |
| 32 | MP0004147_increased_porphyrin_level | 1.50676802 |
| 33 | MP0003283_abnormal_digestive_organ | 1.45206813 |
| 34 | MP0008058_abnormal_DNA_repair | 1.40930420 |
| 35 | MP0001666_abnormal_nutrient_absorption | 1.40748923 |
| 36 | MP0005645_abnormal_hypothalamus_physiol | 1.37366694 |
| 37 | MP0009046_muscle_twitch | 1.37074118 |
| 38 | MP0002272_abnormal_nervous_system | 1.36544419 |
| 39 | MP0005551_abnormal_eye_electrophysiolog | 1.36161641 |
| 40 | MP0004142_abnormal_muscle_tone | 1.35420900 |
| 41 | MP0003718_maternal_effect | 1.29539002 |
| 42 | MP0003183_abnormal_peptide_metabolism | 1.27824036 |
| 43 | MP0002733_abnormal_thermal_nociception | 1.27485956 |
| 44 | MP0004019_abnormal_vitamin_homeostasis | 1.25801509 |
| 45 | MP0001919_abnormal_reproductive_system | 1.21878132 |
| 46 | MP0009745_abnormal_behavioral_response | 1.20620761 |
| 47 | MP0000358_abnormal_cell_content/ | 1.20161782 |
| 48 | MP0004885_abnormal_endolymph | 1.17893735 |
| 49 | MP0001764_abnormal_homeostasis | 1.17675473 |
| 50 | MP0008789_abnormal_olfactory_epithelium | 1.17043441 |
| 51 | MP0001905_abnormal_dopamine_level | 1.15488303 |
| 52 | MP0010094_abnormal_chromosome_stability | 1.14859877 |
| 53 | MP0003868_abnormal_feces_composition | 1.14781914 |
| 54 | MP0002163_abnormal_gland_morphology | 1.14278667 |
| 55 | MP0001970_abnormal_pain_threshold | 1.11638373 |
| 56 | MP0001968_abnormal_touch/_nociception | 1.10768711 |
| 57 | MP0002332_abnormal_exercise_endurance | 1.10637028 |
| 58 | MP0005379_endocrine/exocrine_gland_phen | 1.10002964 |
| 59 | MP0003121_genomic_imprinting | 1.08848628 |
| 60 | MP0005332_abnormal_amino_acid | 1.08604958 |
| 61 | MP0004957_abnormal_blastocyst_morpholog | 1.07581040 |
| 62 | MP0001756_abnormal_urination | 1.06675949 |
| 63 | MP0003787_abnormal_imprinting | 1.06462300 |
| 64 | MP0002876_abnormal_thyroid_physiology | 1.05685289 |
| 65 | MP0004215_abnormal_myocardial_fiber | 1.05428735 |
| 66 | MP0000372_irregular_coat_pigmentation | 0.99537600 |
| 67 | MP0004742_abnormal_vestibular_system | 0.97562690 |
| 68 | MP0002638_abnormal_pupillary_reflex | 0.96430130 |
| 69 | MP0003011_delayed_dark_adaptation | 0.89490596 |
| 70 | MP0005410_abnormal_fertilization | 0.88959366 |
| 71 | MP0000685_abnormal_immune_system | 0.88456388 |
| 72 | MP0005646_abnormal_pituitary_gland | 0.87759278 |
| 73 | MP0005636_abnormal_mineral_homeostasis | 0.87741375 |
| 74 | MP0002572_abnormal_emotion/affect_behav | 0.86812015 |
| 75 | MP0008775_abnormal_heart_ventricle | 0.86749317 |
| 76 | MP0001440_abnormal_grooming_behavior | 0.85982198 |
| 77 | MP0004484_altered_response_of | 0.85680337 |
| 78 | MP0002277_abnormal_respiratory_mucosa | 0.84168655 |
| 79 | MP0002064_seizures | 0.84096805 |
| 80 | MP0002938_white_spotting | 0.80564679 |
| 81 | MP0003122_maternal_imprinting | 0.77920002 |
| 82 | MP0002210_abnormal_sex_determination | 0.77404600 |
| 83 | MP0000230_abnormal_systemic_arterial | 0.76880000 |
| 84 | MP0003137_abnormal_impulse_conducting | 0.76603473 |
| 85 | MP0005464_abnormal_platelet_physiology | 0.74912971 |
| 86 | MP0001929_abnormal_gametogenesis | 0.73273584 |
| 87 | MP0001879_abnormal_lymphatic_vessel | 0.71471888 |
| 88 | MP0000013_abnormal_adipose_tissue | 0.70411473 |
| 89 | MP0005423_abnormal_somatic_nervous | 0.70040234 |
| 90 | MP0008995_early_reproductive_senescence | 0.69546015 |
| 91 | MP0005266_abnormal_metabolism | 0.67292151 |
| 92 | MP0002063_abnormal_learning/memory/cond | 0.66908370 |
| 93 | MP0000653_abnormal_sex_gland | 0.66504189 |
| 94 | MP0003635_abnormal_synaptic_transmissio | 0.66413775 |
| 95 | MP0001485_abnormal_pinna_reflex | 0.65268125 |
| 96 | MP0002090_abnormal_vision | 0.65245600 |
| 97 | MP0005253_abnormal_eye_physiology | 0.64433325 |
| 98 | MP0001145_abnormal_male_reproductive | 0.63910143 |
| 99 | MP0009643_abnormal_urine_homeostasis | 0.63020155 |
| 100 | MP0003880_abnormal_central_pattern | 0.61892224 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.24670284 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.12549485 |
| 3 | Abnormality of the labia minora (HP:0012880) | 4.02496973 |
| 4 | Acute encephalopathy (HP:0006846) | 3.98583991 |
| 5 | Increased CSF lactate (HP:0002490) | 3.97591562 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.77112547 |
| 7 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.71117600 |
| 8 | Abnormality of alanine metabolism (HP:0010916) | 3.71117600 |
| 9 | Hyperalaninemia (HP:0003348) | 3.71117600 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.57769997 |
| 11 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.55974657 |
| 12 | Progressive macrocephaly (HP:0004481) | 3.55683642 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.52612200 |
| 14 | Degeneration of anterior horn cells (HP:0002398) | 3.49718176 |
| 15 | Abnormality of the anterior horn cell (HP:0006802) | 3.49718176 |
| 16 | Type 2 muscle fiber atrophy (HP:0003554) | 3.46747632 |
| 17 | Renal Fanconi syndrome (HP:0001994) | 3.43709228 |
| 18 | Cerebral edema (HP:0002181) | 3.42263298 |
| 19 | Lipid accumulation in hepatocytes (HP:0006561) | 3.38571365 |
| 20 | Hepatic necrosis (HP:0002605) | 3.37193158 |
| 21 | Increased serum lactate (HP:0002151) | 3.35858467 |
| 22 | Abolished electroretinogram (ERG) (HP:0000550) | 3.20307452 |
| 23 | Exertional dyspnea (HP:0002875) | 3.07265677 |
| 24 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.00182691 |
| 25 | Parakeratosis (HP:0001036) | 2.99971297 |
| 26 | Panhypogammaglobulinemia (HP:0003139) | 2.97321629 |
| 27 | Colon cancer (HP:0003003) | 2.91894578 |
| 28 | Optic disc pallor (HP:0000543) | 2.86017022 |
| 29 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.84561780 |
| 30 | Increased serum pyruvate (HP:0003542) | 2.80387224 |
| 31 | Congenital stationary night blindness (HP:0007642) | 2.70167051 |
| 32 | Lactic acidosis (HP:0003128) | 2.69685001 |
| 33 | Lethargy (HP:0001254) | 2.67265059 |
| 34 | Muscle fiber atrophy (HP:0100295) | 2.65572571 |
| 35 | Methylmalonic aciduria (HP:0012120) | 2.62142796 |
| 36 | Abnormality of serum amino acid levels (HP:0003112) | 2.59935143 |
| 37 | Pendular nystagmus (HP:0012043) | 2.57309849 |
| 38 | Entropion (HP:0000621) | 2.54183567 |
| 39 | Spinal muscular atrophy (HP:0007269) | 2.54018898 |
| 40 | Adrenal hypoplasia (HP:0000835) | 2.53763052 |
| 41 | Abnormality of urine glucose concentration (HP:0011016) | 2.53328465 |
| 42 | Glycosuria (HP:0003076) | 2.53328465 |
| 43 | Dyschromatopsia (HP:0007641) | 2.52373543 |
| 44 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.51509697 |
| 45 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.51509697 |
| 46 | Respiratory failure (HP:0002878) | 2.46141044 |
| 47 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.46117258 |
| 48 | Abnormality of renal resorption (HP:0011038) | 2.46030236 |
| 49 | Pigmentary retinal degeneration (HP:0001146) | 2.37878186 |
| 50 | Increased intramyocellular lipid droplets (HP:0012240) | 2.35747023 |
| 51 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.33326407 |
| 52 | Abnormality of magnesium homeostasis (HP:0004921) | 2.31837567 |
| 53 | 3-Methylglutaconic aciduria (HP:0003535) | 2.27526607 |
| 54 | Myokymia (HP:0002411) | 2.22172863 |
| 55 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.16820336 |
| 56 | Nausea (HP:0002018) | 2.16016509 |
| 57 | Lissencephaly (HP:0001339) | 2.15258090 |
| 58 | Erythroderma (HP:0001019) | 2.11503839 |
| 59 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.10257205 |
| 60 | Abnormality of glycolysis (HP:0004366) | 2.09858248 |
| 61 | Methylmalonic acidemia (HP:0002912) | 2.09837633 |
| 62 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.09818593 |
| 63 | Constricted visual fields (HP:0001133) | 2.09432358 |
| 64 | Ependymoma (HP:0002888) | 2.08437028 |
| 65 | Asplenia (HP:0001746) | 2.06748863 |
| 66 | True hermaphroditism (HP:0010459) | 2.05673355 |
| 67 | Exercise intolerance (HP:0003546) | 2.05118685 |
| 68 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.04454074 |
| 69 | Pancreatic fibrosis (HP:0100732) | 2.02940281 |
| 70 | Hyperglycinemia (HP:0002154) | 2.02891729 |
| 71 | Central scotoma (HP:0000603) | 2.02864047 |
| 72 | CNS demyelination (HP:0007305) | 2.02538512 |
| 73 | Decreased muscle mass (HP:0003199) | 2.02267407 |
| 74 | Respiratory difficulties (HP:0002880) | 2.01269003 |
| 75 | X-linked dominant inheritance (HP:0001423) | 1.98617122 |
| 76 | Hyperphosphaturia (HP:0003109) | 1.98272379 |
| 77 | Generalized aminoaciduria (HP:0002909) | 1.96253449 |
| 78 | Increased muscle lipid content (HP:0009058) | 1.96009187 |
| 79 | Abnormality of midbrain morphology (HP:0002418) | 1.93764783 |
| 80 | Molar tooth sign on MRI (HP:0002419) | 1.93764783 |
| 81 | Supernumerary spleens (HP:0009799) | 1.93293297 |
| 82 | Aplastic anemia (HP:0001915) | 1.92956279 |
| 83 | Hypomagnesemia (HP:0002917) | 1.92594445 |
| 84 | Abnormality of DNA repair (HP:0003254) | 1.90321109 |
| 85 | Pancreatic cysts (HP:0001737) | 1.89678134 |
| 86 | Limb hypertonia (HP:0002509) | 1.87932097 |
| 87 | Alkalosis (HP:0001948) | 1.85822994 |
| 88 | Hyperglycinuria (HP:0003108) | 1.82210812 |
| 89 | Cerebral hypomyelination (HP:0006808) | 1.79607058 |
| 90 | Metabolic acidosis (HP:0001942) | 1.76870518 |
| 91 | Poor speech (HP:0002465) | 1.76430396 |
| 92 | Large eyes (HP:0001090) | 1.75607886 |
| 93 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 1.74115690 |
| 94 | Hypothermia (HP:0002045) | 1.73154573 |
| 95 | Vitreoretinal degeneration (HP:0000655) | 1.71747498 |
| 96 | Dicarboxylic aciduria (HP:0003215) | 1.70931524 |
| 97 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.70931524 |
| 98 | Emotional lability (HP:0000712) | 1.68836766 |
| 99 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.68726212 |
| 100 | Stenosis of the external auditory canal (HP:0000402) | 1.67842681 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK16 | 6.02851169 |
| 2 | VRK2 | 4.82189716 |
| 3 | BUB1 | 3.16071018 |
| 4 | MAP3K12 | 3.08920408 |
| 5 | PDK2 | 3.07667026 |
| 6 | MST4 | 3.03530329 |
| 7 | EIF2AK3 | 2.85786496 |
| 8 | NUAK1 | 2.80937171 |
| 9 | TAF1 | 2.62120904 |
| 10 | PLK4 | 2.45871221 |
| 11 | VRK1 | 2.30982078 |
| 12 | WNK3 | 2.28230825 |
| 13 | EIF2AK1 | 2.20008962 |
| 14 | ADRBK2 | 2.10146473 |
| 15 | TAOK3 | 1.96179830 |
| 16 | MAP4K2 | 1.80913649 |
| 17 | STK39 | 1.72247776 |
| 18 | PLK2 | 1.69565209 |
| 19 | SMG1 | 1.60760447 |
| 20 | GRK1 | 1.59591395 |
| 21 | NEK1 | 1.47195538 |
| 22 | BMPR1B | 1.39899427 |
| 23 | OXSR1 | 1.38097250 |
| 24 | PLK3 | 1.37449145 |
| 25 | PINK1 | 1.19391852 |
| 26 | DYRK2 | 1.15301017 |
| 27 | MAP2K6 | 1.15022425 |
| 28 | MAPKAPK5 | 1.14174233 |
| 29 | MYLK | 1.13946255 |
| 30 | GRK5 | 1.12614160 |
| 31 | DAPK1 | 1.11916455 |
| 32 | PHKG2 | 1.10575001 |
| 33 | PHKG1 | 1.10575001 |
| 34 | FRK | 1.09028386 |
| 35 | CDK8 | 1.09001773 |
| 36 | WNK4 | 1.08016088 |
| 37 | EIF2AK2 | 1.06950120 |
| 38 | PBK | 1.04060984 |
| 39 | BCKDK | 1.00446831 |
| 40 | STK38L | 0.97432961 |
| 41 | TIE1 | 0.95698129 |
| 42 | CCNB1 | 0.94699488 |
| 43 | CAMKK2 | 0.86963610 |
| 44 | PIK3CG | 0.81009155 |
| 45 | TESK2 | 0.72769916 |
| 46 | INSRR | 0.70135718 |
| 47 | ZAK | 0.66566295 |
| 48 | TXK | 0.65456725 |
| 49 | RIPK4 | 0.64102687 |
| 50 | NME2 | 0.63173664 |
| 51 | ILK | 0.60645423 |
| 52 | PRKCQ | 0.59003045 |
| 53 | AURKB | 0.58999063 |
| 54 | IRAK4 | 0.56921404 |
| 55 | MAP3K4 | 0.56300094 |
| 56 | MKNK1 | 0.55714069 |
| 57 | NEK2 | 0.55571190 |
| 58 | SYK | 0.55303770 |
| 59 | DAPK3 | 0.54986241 |
| 60 | PRKCG | 0.53937176 |
| 61 | TSSK6 | 0.53681218 |
| 62 | CSNK1G3 | 0.53512473 |
| 63 | SRPK1 | 0.52745454 |
| 64 | CSNK1G2 | 0.49376116 |
| 65 | PAK3 | 0.48410694 |
| 66 | TLK1 | 0.48293613 |
| 67 | PRKCI | 0.46245333 |
| 68 | FES | 0.45926753 |
| 69 | LRRK2 | 0.45805398 |
| 70 | MAP3K9 | 0.44853746 |
| 71 | TEC | 0.44431782 |
| 72 | CDC7 | 0.41893919 |
| 73 | PLK1 | 0.40900921 |
| 74 | CDK9 | 0.40674660 |
| 75 | LIMK1 | 0.40025373 |
| 76 | ITK | 0.40002747 |
| 77 | NEK9 | 0.34896035 |
| 78 | CSNK1A1L | 0.33202485 |
| 79 | ATR | 0.33190619 |
| 80 | KIT | 0.31565221 |
| 81 | PRKACA | 0.30880722 |
| 82 | CAMKK1 | 0.30799148 |
| 83 | CSNK2A2 | 0.30631637 |
| 84 | IKBKB | 0.30351930 |
| 85 | AURKA | 0.28764398 |
| 86 | ALK | 0.28751006 |
| 87 | PRKCE | 0.28739178 |
| 88 | ADRBK1 | 0.28553210 |
| 89 | OBSCN | 0.27689156 |
| 90 | PRKCA | 0.27650283 |
| 91 | PRKG1 | 0.27645221 |
| 92 | TNK2 | 0.27212918 |
| 93 | CSNK1G1 | 0.27080596 |
| 94 | NME1 | 0.26525407 |
| 95 | MKNK2 | 0.24525016 |
| 96 | TGFBR1 | 0.24379569 |
| 97 | BRSK1 | 0.23958736 |
| 98 | CSNK2A1 | 0.22588006 |
| 99 | ABL2 | 0.20908247 |
| 100 | MINK1 | 0.20800364 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.08168604 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.40725791 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 2.96668776 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 2.83844516 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.48382543 |
| 6 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.28983752 |
| 7 | DNA replication_Homo sapiens_hsa03030 | 2.20788936 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.18899417 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.07052926 |
| 10 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.00154527 |
| 11 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.90635203 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 1.87236693 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.83416611 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 1.83350378 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.73996293 |
| 16 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.72483451 |
| 17 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.69810348 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.68215762 |
| 19 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.67245873 |
| 20 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.53944646 |
| 21 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.50410224 |
| 22 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.46959270 |
| 23 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.43514123 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.42093096 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42009431 |
| 26 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.41845768 |
| 27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.36776429 |
| 28 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.36113580 |
| 29 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.34920238 |
| 30 | Peroxisome_Homo sapiens_hsa04146 | 1.32423584 |
| 31 | Base excision repair_Homo sapiens_hsa03410 | 1.30247257 |
| 32 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.27403903 |
| 33 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.27362859 |
| 34 | Asthma_Homo sapiens_hsa05310 | 1.26868152 |
| 35 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.26820929 |
| 36 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.26213924 |
| 37 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.25250676 |
| 38 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.22670522 |
| 39 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.17727001 |
| 40 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.16895720 |
| 41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.15194001 |
| 42 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.15071513 |
| 43 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.14973776 |
| 44 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.14269999 |
| 45 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.11811080 |
| 46 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.10861786 |
| 47 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.08610805 |
| 48 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.07429716 |
| 49 | RNA degradation_Homo sapiens_hsa03018 | 1.06061616 |
| 50 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.05758089 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.04193269 |
| 52 | Retinol metabolism_Homo sapiens_hsa00830 | 1.01914864 |
| 53 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.99887375 |
| 54 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.97113471 |
| 55 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.96813993 |
| 56 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.95985364 |
| 57 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.95153544 |
| 58 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.93964881 |
| 59 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.92768478 |
| 60 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.89282735 |
| 61 | RNA transport_Homo sapiens_hsa03013 | 0.87102087 |
| 62 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.86484379 |
| 63 | Purine metabolism_Homo sapiens_hsa00230 | 0.82991246 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.81012133 |
| 65 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80949624 |
| 66 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.80296993 |
| 67 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.79404647 |
| 68 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.79371952 |
| 69 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.77759023 |
| 70 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76852744 |
| 71 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.75424154 |
| 72 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.68905045 |
| 73 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.68298497 |
| 74 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.67725370 |
| 75 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.67615970 |
| 76 | Allograft rejection_Homo sapiens_hsa05330 | 0.67580062 |
| 77 | Carbon metabolism_Homo sapiens_hsa01200 | 0.65645692 |
| 78 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.63693809 |
| 79 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.62939422 |
| 80 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.61077078 |
| 81 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.60040085 |
| 82 | Phototransduction_Homo sapiens_hsa04744 | 0.58470160 |
| 83 | Nicotine addiction_Homo sapiens_hsa05033 | 0.58164929 |
| 84 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.58134886 |
| 85 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.55036090 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.54313393 |
| 87 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.53649345 |
| 88 | Sulfur relay system_Homo sapiens_hsa04122 | 0.52064403 |
| 89 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.50848456 |
| 90 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.48295697 |
| 91 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.47534529 |
| 92 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.43197958 |
| 93 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.42294641 |
| 94 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41952376 |
| 95 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.40766467 |
| 96 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.36210750 |
| 97 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.32632183 |
| 98 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.32116441 |
| 99 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.30747294 |
| 100 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.30578628 |

