COX6A1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.20842584
2DNA deamination (GO:0045006)5.74755336
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40089712
4ATP synthesis coupled proton transport (GO:0015986)5.30099057
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.30099057
6behavioral response to nicotine (GO:0035095)5.17311202
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.84238863
8chaperone-mediated protein transport (GO:0072321)4.39758516
9ribosomal small subunit assembly (GO:0000028)4.25432534
10water-soluble vitamin biosynthetic process (GO:0042364)4.25050649
11rRNA modification (GO:0000154)4.02511043
12positive regulation of prostaglandin secretion (GO:0032308)3.96923729
13protein complex biogenesis (GO:0070271)3.82626633
14respiratory electron transport chain (GO:0022904)3.70530764
15electron transport chain (GO:0022900)3.68769016
16DNA double-strand break processing (GO:0000729)3.66931810
17respiratory chain complex IV assembly (GO:0008535)3.61608421
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.61191436
19protein deneddylation (GO:0000338)3.60375801
20nucleoside diphosphate catabolic process (GO:0009134)3.59381465
21NADH metabolic process (GO:0006734)3.56301835
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.55616415
23regulation of cellular amino acid metabolic process (GO:0006521)3.51902725
24protein neddylation (GO:0045116)3.49637407
25cytochrome complex assembly (GO:0017004)3.47224206
26mitochondrial respiratory chain complex assembly (GO:0033108)3.46216776
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44075267
28intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44075267
29telomere maintenance via semi-conservative replication (GO:0032201)3.43637732
30response to pheromone (GO:0019236)3.43129928
31signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.41930737
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.41930737
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.41930737
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38582327
35hydrogen ion transmembrane transport (GO:1902600)3.36406868
36regulation of prostaglandin secretion (GO:0032306)3.35026823
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34290450
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.33866160
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.33866160
40NADH dehydrogenase complex assembly (GO:0010257)3.33866160
41DNA catabolic process, exonucleolytic (GO:0000738)3.31922507
42positive regulation of fatty acid transport (GO:2000193)3.29183170
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.23835656
44signal transduction involved in DNA damage checkpoint (GO:0072422)3.23835656
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22740730
46cullin deneddylation (GO:0010388)3.21746967
47artery smooth muscle contraction (GO:0014824)3.18874552
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.17501409
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15906887
50amino acid salvage (GO:0043102)3.15102699
51L-methionine salvage (GO:0071267)3.15102699
52L-methionine biosynthetic process (GO:0071265)3.15102699
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.14896739
54positive regulation of icosanoid secretion (GO:0032305)3.13491112
55negative regulation of macroautophagy (GO:0016242)3.13258176
56protein-cofactor linkage (GO:0018065)3.11790916
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07072423
58regulation of mitochondrial translation (GO:0070129)3.04300001
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03901349
60spliceosomal complex assembly (GO:0000245)3.03001961
61GTP biosynthetic process (GO:0006183)3.02923353
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02704922
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02674451
64ATP biosynthetic process (GO:0006754)3.02595850
65rRNA methylation (GO:0031167)2.99389729
66telomere maintenance via telomerase (GO:0007004)2.96400430
67proton transport (GO:0015992)2.94612417
68hydrogen transport (GO:0006818)2.94193757
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93500302
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92297832
71negative regulation of ligase activity (GO:0051352)2.92297832
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90120984
73cytidine metabolic process (GO:0046087)2.89859782
74cytidine catabolic process (GO:0006216)2.89859782
75cytidine deamination (GO:0009972)2.89859782
76protein targeting to mitochondrion (GO:0006626)2.89529897
77protein K6-linked ubiquitination (GO:0085020)2.89288864
78DNA damage response, detection of DNA damage (GO:0042769)2.89195811
79peptidyl-histidine modification (GO:0018202)2.83981376
80regulation of cellular amine metabolic process (GO:0033238)2.82872719
81telomere maintenance via recombination (GO:0000722)2.82560867
82signal peptide processing (GO:0006465)2.82290647
83inner mitochondrial membrane organization (GO:0007007)2.82138165
84positive regulation of ligase activity (GO:0051351)2.79408189
85regulation of action potential (GO:0098900)2.77574506
86establishment of protein localization to mitochondrion (GO:0072655)2.74237902
87nucleotide-excision repair, DNA gap filling (GO:0006297)2.73951907
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.73663693
89tonic smooth muscle contraction (GO:0014820)2.70041349
90arginine metabolic process (GO:0006525)2.69201649
91maturation of 5.8S rRNA (GO:0000460)2.69117278
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.68283436
93L-phenylalanine metabolic process (GO:0006558)2.68283436
94replication fork processing (GO:0031297)2.67613019
95L-ascorbic acid metabolic process (GO:0019852)2.67007972
96protein localization to mitochondrion (GO:0070585)2.66762494
97methionine biosynthetic process (GO:0009086)2.65868542
98positive regulation of cell cycle arrest (GO:0071158)2.65596947
99glyoxylate metabolic process (GO:0046487)2.64422629
100pyrimidine ribonucleoside catabolic process (GO:0046133)2.63701190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.25167033
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.23108118
3VDR_22108803_ChIP-Seq_LS180_Human4.08257628
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.06789497
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.64670737
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33815350
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26308721
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.02416335
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98566202
10EZH2_22144423_ChIP-Seq_EOC_Human2.92607848
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.79709189
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67206073
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58544333
14ZNF274_21170338_ChIP-Seq_K562_Hela2.36228297
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27473687
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24275340
17ELK1_19687146_ChIP-ChIP_HELA_Human2.21765467
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.16309590
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.13427470
20VDR_23849224_ChIP-Seq_CD4+_Human2.11462947
21FOXP3_21729870_ChIP-Seq_TREG_Human2.11090103
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07395186
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04790985
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88812122
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88555078
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.87867944
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82290107
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.77055599
29IGF1R_20145208_ChIP-Seq_DFB_Human1.69213049
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.68970996
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67122650
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64723615
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58351305
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.54323603
35AR_20517297_ChIP-Seq_VCAP_Human1.43714512
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40545614
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37680931
38NCOR_22424771_ChIP-Seq_293T_Human1.37265231
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35911963
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34746762
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32983969
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31326700
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30272946
44MYC_18940864_ChIP-ChIP_HL60_Human1.29738606
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27688753
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27582165
47TP53_22573176_ChIP-Seq_HFKS_Human1.25698580
48GABP_19822575_ChIP-Seq_HepG2_Human1.25660265
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23848528
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23485821
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23330867
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23330317
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.23330317
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23293473
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22207088
56DCP1A_22483619_ChIP-Seq_HELA_Human1.21769746
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19339623
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.17528336
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16614675
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.16055092
61NANOG_19829295_ChIP-Seq_ESCs_Human1.15288645
62SOX2_19829295_ChIP-Seq_ESCs_Human1.15288645
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.15169807
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14704986
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13159950
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09018370
67ER_23166858_ChIP-Seq_MCF-7_Human1.08524883
68EWS_26573619_Chip-Seq_HEK293_Human1.07584415
69TTF2_22483619_ChIP-Seq_HELA_Human1.06244383
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05578508
71TAF2_19829295_ChIP-Seq_ESCs_Human1.05573753
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03823469
73IRF1_19129219_ChIP-ChIP_H3396_Human1.03622130
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03018669
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.02958122
76MYC_19829295_ChIP-Seq_ESCs_Human1.00742033
77NOTCH1_21737748_ChIP-Seq_TLL_Human0.99288047
78P300_19829295_ChIP-Seq_ESCs_Human0.96838583
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96151753
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94277577
81ERA_21632823_ChIP-Seq_H3396_Human0.93929930
82GATA3_26560356_Chip-Seq_TH2_Human0.93167734
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93030242
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92112789
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.91922297
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91047427
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84617857
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83867514
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83469114
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83360518
91KDM5A_27292631_Chip-Seq_BREAST_Human0.83155963
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82650858
93P53_21459846_ChIP-Seq_SAOS-2_Human0.82554996
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81773840
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79988276
96STAT3_18555785_Chip-Seq_ESCs_Mouse0.79268538
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79026137
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78121933
99HTT_18923047_ChIP-ChIP_STHdh_Human0.77386563
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.76976993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.89300297
2MP0005360_urolithiasis3.86862476
3MP0005084_abnormal_gallbladder_morpholo3.71751461
4MP0002138_abnormal_hepatobiliary_system3.61435899
5MP0005085_abnormal_gallbladder_physiolo3.41321872
6MP0010386_abnormal_urinary_bladder3.32553620
7MP0004145_abnormal_muscle_electrophysio2.75917208
8MP0002102_abnormal_ear_morphology2.72633459
9MP0003195_calcinosis2.54681567
10MP0008875_abnormal_xenobiotic_pharmacok2.51264109
11MP0006036_abnormal_mitochondrial_physio2.43186597
12MP0008877_abnormal_DNA_methylation2.30747612
13MP0003786_premature_aging2.21766350
14MP0002160_abnormal_reproductive_system2.13902980
15MP0006276_abnormal_autonomic_nervous2.13823863
16MP0006035_abnormal_mitochondrial_morpho2.11851147
17MP0005083_abnormal_biliary_tract2.07669564
18MP0002139_abnormal_hepatobiliary_system2.06927160
19MP0008872_abnormal_physiological_respon2.05647609
20MP0005365_abnormal_bile_salt2.04044547
21MP0001986_abnormal_taste_sensitivity1.95548506
22MP0005389_reproductive_system_phenotype1.90396546
23MP0006072_abnormal_retinal_apoptosis1.89797989
24MP0010329_abnormal_lipoprotein_level1.82454409
25MP0006054_spinal_hemorrhage1.74814617
26MP0003186_abnormal_redox_activity1.68590569
27MP0001529_abnormal_vocalization1.65339727
28MP0003646_muscle_fatigue1.61057529
29MP0009697_abnormal_copulation1.59680267
30MP0002837_dystrophic_cardiac_calcinosis1.59510429
31MP0003252_abnormal_bile_duct1.56312890
32MP0004147_increased_porphyrin_level1.50676802
33MP0003283_abnormal_digestive_organ1.45206813
34MP0008058_abnormal_DNA_repair1.40930420
35MP0001666_abnormal_nutrient_absorption1.40748923
36MP0005645_abnormal_hypothalamus_physiol1.37366694
37MP0009046_muscle_twitch1.37074118
38MP0002272_abnormal_nervous_system1.36544419
39MP0005551_abnormal_eye_electrophysiolog1.36161641
40MP0004142_abnormal_muscle_tone1.35420900
41MP0003718_maternal_effect1.29539002
42MP0003183_abnormal_peptide_metabolism1.27824036
43MP0002733_abnormal_thermal_nociception1.27485956
44MP0004019_abnormal_vitamin_homeostasis1.25801509
45MP0001919_abnormal_reproductive_system1.21878132
46MP0009745_abnormal_behavioral_response1.20620761
47MP0000358_abnormal_cell_content/1.20161782
48MP0004885_abnormal_endolymph1.17893735
49MP0001764_abnormal_homeostasis1.17675473
50MP0008789_abnormal_olfactory_epithelium1.17043441
51MP0001905_abnormal_dopamine_level1.15488303
52MP0010094_abnormal_chromosome_stability1.14859877
53MP0003868_abnormal_feces_composition1.14781914
54MP0002163_abnormal_gland_morphology1.14278667
55MP0001970_abnormal_pain_threshold1.11638373
56MP0001968_abnormal_touch/_nociception1.10768711
57MP0002332_abnormal_exercise_endurance1.10637028
58MP0005379_endocrine/exocrine_gland_phen1.10002964
59MP0003121_genomic_imprinting1.08848628
60MP0005332_abnormal_amino_acid1.08604958
61MP0004957_abnormal_blastocyst_morpholog1.07581040
62MP0001756_abnormal_urination1.06675949
63MP0003787_abnormal_imprinting1.06462300
64MP0002876_abnormal_thyroid_physiology1.05685289
65MP0004215_abnormal_myocardial_fiber1.05428735
66MP0000372_irregular_coat_pigmentation0.99537600
67MP0004742_abnormal_vestibular_system0.97562690
68MP0002638_abnormal_pupillary_reflex0.96430130
69MP0003011_delayed_dark_adaptation0.89490596
70MP0005410_abnormal_fertilization0.88959366
71MP0000685_abnormal_immune_system0.88456388
72MP0005646_abnormal_pituitary_gland0.87759278
73MP0005636_abnormal_mineral_homeostasis0.87741375
74MP0002572_abnormal_emotion/affect_behav0.86812015
75MP0008775_abnormal_heart_ventricle0.86749317
76MP0001440_abnormal_grooming_behavior0.85982198
77MP0004484_altered_response_of0.85680337
78MP0002277_abnormal_respiratory_mucosa0.84168655
79MP0002064_seizures0.84096805
80MP0002938_white_spotting0.80564679
81MP0003122_maternal_imprinting0.77920002
82MP0002210_abnormal_sex_determination0.77404600
83MP0000230_abnormal_systemic_arterial0.76880000
84MP0003137_abnormal_impulse_conducting0.76603473
85MP0005464_abnormal_platelet_physiology0.74912971
86MP0001929_abnormal_gametogenesis0.73273584
87MP0001879_abnormal_lymphatic_vessel0.71471888
88MP0000013_abnormal_adipose_tissue0.70411473
89MP0005423_abnormal_somatic_nervous0.70040234
90MP0008995_early_reproductive_senescence0.69546015
91MP0005266_abnormal_metabolism0.67292151
92MP0002063_abnormal_learning/memory/cond0.66908370
93MP0000653_abnormal_sex_gland0.66504189
94MP0003635_abnormal_synaptic_transmissio0.66413775
95MP0001485_abnormal_pinna_reflex0.65268125
96MP0002090_abnormal_vision0.65245600
97MP0005253_abnormal_eye_physiology0.64433325
98MP0001145_abnormal_male_reproductive0.63910143
99MP0009643_abnormal_urine_homeostasis0.63020155
100MP0003880_abnormal_central_pattern0.61892224

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.24670284
2Mitochondrial inheritance (HP:0001427)4.12549485
3Abnormality of the labia minora (HP:0012880)4.02496973
4Acute encephalopathy (HP:0006846)3.98583991
5Increased CSF lactate (HP:0002490)3.97591562
6Abnormal mitochondria in muscle tissue (HP:0008316)3.77112547
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.71117600
8Abnormality of alanine metabolism (HP:0010916)3.71117600
9Hyperalaninemia (HP:0003348)3.71117600
10Increased hepatocellular lipid droplets (HP:0006565)3.57769997
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.55974657
12Progressive macrocephaly (HP:0004481)3.55683642
13Hepatocellular necrosis (HP:0001404)3.52612200
14Degeneration of anterior horn cells (HP:0002398)3.49718176
15Abnormality of the anterior horn cell (HP:0006802)3.49718176
16Type 2 muscle fiber atrophy (HP:0003554)3.46747632
17Renal Fanconi syndrome (HP:0001994)3.43709228
18Cerebral edema (HP:0002181)3.42263298
19Lipid accumulation in hepatocytes (HP:0006561)3.38571365
20Hepatic necrosis (HP:0002605)3.37193158
21Increased serum lactate (HP:0002151)3.35858467
22Abolished electroretinogram (ERG) (HP:0000550)3.20307452
23Exertional dyspnea (HP:0002875)3.07265677
24Abnormal rod and cone electroretinograms (HP:0008323)3.00182691
25Parakeratosis (HP:0001036)2.99971297
26Panhypogammaglobulinemia (HP:0003139)2.97321629
27Colon cancer (HP:0003003)2.91894578
28Optic disc pallor (HP:0000543)2.86017022
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.84561780
30Increased serum pyruvate (HP:0003542)2.80387224
31Congenital stationary night blindness (HP:0007642)2.70167051
32Lactic acidosis (HP:0003128)2.69685001
33Lethargy (HP:0001254)2.67265059
34Muscle fiber atrophy (HP:0100295)2.65572571
35Methylmalonic aciduria (HP:0012120)2.62142796
36Abnormality of serum amino acid levels (HP:0003112)2.59935143
37Pendular nystagmus (HP:0012043)2.57309849
38Entropion (HP:0000621)2.54183567
39Spinal muscular atrophy (HP:0007269)2.54018898
40Adrenal hypoplasia (HP:0000835)2.53763052
41Abnormality of urine glucose concentration (HP:0011016)2.53328465
42Glycosuria (HP:0003076)2.53328465
43Dyschromatopsia (HP:0007641)2.52373543
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.51509697
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.51509697
46Respiratory failure (HP:0002878)2.46141044
47Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46117258
48Abnormality of renal resorption (HP:0011038)2.46030236
49Pigmentary retinal degeneration (HP:0001146)2.37878186
50Increased intramyocellular lipid droplets (HP:0012240)2.35747023
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33326407
52Abnormality of magnesium homeostasis (HP:0004921)2.31837567
533-Methylglutaconic aciduria (HP:0003535)2.27526607
54Myokymia (HP:0002411)2.22172863
55Congenital ichthyosiform erythroderma (HP:0007431)2.16820336
56Nausea (HP:0002018)2.16016509
57Lissencephaly (HP:0001339)2.15258090
58Erythroderma (HP:0001019)2.11503839
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10257205
60Abnormality of glycolysis (HP:0004366)2.09858248
61Methylmalonic acidemia (HP:0002912)2.09837633
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.09818593
63Constricted visual fields (HP:0001133)2.09432358
64Ependymoma (HP:0002888)2.08437028
65Asplenia (HP:0001746)2.06748863
66True hermaphroditism (HP:0010459)2.05673355
67Exercise intolerance (HP:0003546)2.05118685
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04454074
69Pancreatic fibrosis (HP:0100732)2.02940281
70Hyperglycinemia (HP:0002154)2.02891729
71Central scotoma (HP:0000603)2.02864047
72CNS demyelination (HP:0007305)2.02538512
73Decreased muscle mass (HP:0003199)2.02267407
74Respiratory difficulties (HP:0002880)2.01269003
75X-linked dominant inheritance (HP:0001423)1.98617122
76Hyperphosphaturia (HP:0003109)1.98272379
77Generalized aminoaciduria (HP:0002909)1.96253449
78Increased muscle lipid content (HP:0009058)1.96009187
79Abnormality of midbrain morphology (HP:0002418)1.93764783
80Molar tooth sign on MRI (HP:0002419)1.93764783
81Supernumerary spleens (HP:0009799)1.93293297
82Aplastic anemia (HP:0001915)1.92956279
83Hypomagnesemia (HP:0002917)1.92594445
84Abnormality of DNA repair (HP:0003254)1.90321109
85Pancreatic cysts (HP:0001737)1.89678134
86Limb hypertonia (HP:0002509)1.87932097
87Alkalosis (HP:0001948)1.85822994
88Hyperglycinuria (HP:0003108)1.82210812
89Cerebral hypomyelination (HP:0006808)1.79607058
90Metabolic acidosis (HP:0001942)1.76870518
91Poor speech (HP:0002465)1.76430396
92Large eyes (HP:0001090)1.75607886
93Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74115690
94Hypothermia (HP:0002045)1.73154573
95Vitreoretinal degeneration (HP:0000655)1.71747498
96Dicarboxylic aciduria (HP:0003215)1.70931524
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70931524
98Emotional lability (HP:0000712)1.68836766
99Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68726212
100Stenosis of the external auditory canal (HP:0000402)1.67842681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.02851169
2VRK24.82189716
3BUB13.16071018
4MAP3K123.08920408
5PDK23.07667026
6MST43.03530329
7EIF2AK32.85786496
8NUAK12.80937171
9TAF12.62120904
10PLK42.45871221
11VRK12.30982078
12WNK32.28230825
13EIF2AK12.20008962
14ADRBK22.10146473
15TAOK31.96179830
16MAP4K21.80913649
17STK391.72247776
18PLK21.69565209
19SMG11.60760447
20GRK11.59591395
21NEK11.47195538
22BMPR1B1.39899427
23OXSR11.38097250
24PLK31.37449145
25PINK11.19391852
26DYRK21.15301017
27MAP2K61.15022425
28MAPKAPK51.14174233
29MYLK1.13946255
30GRK51.12614160
31DAPK11.11916455
32PHKG21.10575001
33PHKG11.10575001
34FRK1.09028386
35CDK81.09001773
36WNK41.08016088
37EIF2AK21.06950120
38PBK1.04060984
39BCKDK1.00446831
40STK38L0.97432961
41TIE10.95698129
42CCNB10.94699488
43CAMKK20.86963610
44PIK3CG0.81009155
45TESK20.72769916
46INSRR0.70135718
47ZAK0.66566295
48TXK0.65456725
49RIPK40.64102687
50NME20.63173664
51ILK0.60645423
52PRKCQ0.59003045
53AURKB0.58999063
54IRAK40.56921404
55MAP3K40.56300094
56MKNK10.55714069
57NEK20.55571190
58SYK0.55303770
59DAPK30.54986241
60PRKCG0.53937176
61TSSK60.53681218
62CSNK1G30.53512473
63SRPK10.52745454
64CSNK1G20.49376116
65PAK30.48410694
66TLK10.48293613
67PRKCI0.46245333
68FES0.45926753
69LRRK20.45805398
70MAP3K90.44853746
71TEC0.44431782
72CDC70.41893919
73PLK10.40900921
74CDK90.40674660
75LIMK10.40025373
76ITK0.40002747
77NEK90.34896035
78CSNK1A1L0.33202485
79ATR0.33190619
80KIT0.31565221
81PRKACA0.30880722
82CAMKK10.30799148
83CSNK2A20.30631637
84IKBKB0.30351930
85AURKA0.28764398
86ALK0.28751006
87PRKCE0.28739178
88ADRBK10.28553210
89OBSCN0.27689156
90PRKCA0.27650283
91PRKG10.27645221
92TNK20.27212918
93CSNK1G10.27080596
94NME10.26525407
95MKNK20.24525016
96TGFBR10.24379569
97BRSK10.23958736
98CSNK2A10.22588006
99ABL20.20908247
100MINK10.20800364

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.08168604
2Oxidative phosphorylation_Homo sapiens_hsa001903.40725791
3Parkinsons disease_Homo sapiens_hsa050122.96668776
4Mismatch repair_Homo sapiens_hsa034302.83844516
5Protein export_Homo sapiens_hsa030602.48382543
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28983752
7DNA replication_Homo sapiens_hsa030302.20788936
8Ribosome_Homo sapiens_hsa030102.18899417
9Nucleotide excision repair_Homo sapiens_hsa034202.07052926
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.00154527
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90635203
12Alzheimers disease_Homo sapiens_hsa050101.87236693
13Homologous recombination_Homo sapiens_hsa034401.83416611
14RNA polymerase_Homo sapiens_hsa030201.83350378
15One carbon pool by folate_Homo sapiens_hsa006701.73996293
16Propanoate metabolism_Homo sapiens_hsa006401.72483451
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69810348
18Huntingtons disease_Homo sapiens_hsa050161.68215762
19Sulfur metabolism_Homo sapiens_hsa009201.67245873
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53944646
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.50410224
22Linoleic acid metabolism_Homo sapiens_hsa005911.46959270
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43514123
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42093096
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42009431
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41845768
27Basal transcription factors_Homo sapiens_hsa030221.36776429
28Chemical carcinogenesis_Homo sapiens_hsa052041.36113580
29Arginine biosynthesis_Homo sapiens_hsa002201.34920238
30Peroxisome_Homo sapiens_hsa041461.32423584
31Base excision repair_Homo sapiens_hsa034101.30247257
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27403903
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27362859
34Asthma_Homo sapiens_hsa053101.26868152
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26820929
36Tryptophan metabolism_Homo sapiens_hsa003801.26213924
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25250676
38Nitrogen metabolism_Homo sapiens_hsa009101.22670522
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17727001
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16895720
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15194001
42Glutathione metabolism_Homo sapiens_hsa004801.15071513
43Caffeine metabolism_Homo sapiens_hsa002321.14973776
44Collecting duct acid secretion_Homo sapiens_hsa049661.14269999
45Fatty acid degradation_Homo sapiens_hsa000711.11811080
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.10861786
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.08610805
48Pyruvate metabolism_Homo sapiens_hsa006201.07429716
49RNA degradation_Homo sapiens_hsa030181.06061616
50Fat digestion and absorption_Homo sapiens_hsa049751.05758089
51Vitamin B6 metabolism_Homo sapiens_hsa007501.04193269
52Retinol metabolism_Homo sapiens_hsa008301.01914864
53Pyrimidine metabolism_Homo sapiens_hsa002400.99887375
54Fatty acid elongation_Homo sapiens_hsa000620.97113471
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96813993
56Cardiac muscle contraction_Homo sapiens_hsa042600.95985364
57Non-homologous end-joining_Homo sapiens_hsa034500.95153544
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93964881
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92768478
60beta-Alanine metabolism_Homo sapiens_hsa004100.89282735
61RNA transport_Homo sapiens_hsa030130.87102087
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86484379
63Purine metabolism_Homo sapiens_hsa002300.82991246
64Arachidonic acid metabolism_Homo sapiens_hsa005900.81012133
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80949624
66Butanoate metabolism_Homo sapiens_hsa006500.80296993
67Fanconi anemia pathway_Homo sapiens_hsa034600.79404647
68Steroid biosynthesis_Homo sapiens_hsa001000.79371952
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77759023
70Metabolic pathways_Homo sapiens_hsa011000.76852744
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75424154
72Ether lipid metabolism_Homo sapiens_hsa005650.68905045
73Selenocompound metabolism_Homo sapiens_hsa004500.68298497
74Primary immunodeficiency_Homo sapiens_hsa053400.67725370
75Autoimmune thyroid disease_Homo sapiens_hsa053200.67615970
76Allograft rejection_Homo sapiens_hsa053300.67580062
77Carbon metabolism_Homo sapiens_hsa012000.65645692
78Rheumatoid arthritis_Homo sapiens_hsa053230.63693809
79Type I diabetes mellitus_Homo sapiens_hsa049400.62939422
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.61077078
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60040085
82Phototransduction_Homo sapiens_hsa047440.58470160
83Nicotine addiction_Homo sapiens_hsa050330.58164929
84Tyrosine metabolism_Homo sapiens_hsa003500.58134886
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55036090
86Fatty acid metabolism_Homo sapiens_hsa012120.54313393
87Complement and coagulation cascades_Homo sapiens_hsa046100.53649345
88Sulfur relay system_Homo sapiens_hsa041220.52064403
89Biosynthesis of amino acids_Homo sapiens_hsa012300.50848456
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48295697
91Regulation of autophagy_Homo sapiens_hsa041400.47534529
92Glutamatergic synapse_Homo sapiens_hsa047240.43197958
93Arginine and proline metabolism_Homo sapiens_hsa003300.42294641
94Folate biosynthesis_Homo sapiens_hsa007900.41952376
95Graft-versus-host disease_Homo sapiens_hsa053320.40766467
96PPAR signaling pathway_Homo sapiens_hsa033200.36210750
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.32632183
98Glycerolipid metabolism_Homo sapiens_hsa005610.32116441
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30747294
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30578628

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »