COX6A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.36623180
2cardiac myofibril assembly (GO:0055003)8.59717923
3myofibril assembly (GO:0030239)7.92465658
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.57267943
5muscle filament sliding (GO:0030049)7.37533154
6actin-myosin filament sliding (GO:0033275)7.37533154
7negative regulation of potassium ion transmembrane transport (GO:1901380)6.88624293
8response to muscle activity (GO:0014850)6.79120365
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.76890103
10cardiac muscle contraction (GO:0060048)6.76238634
11plasma membrane repair (GO:0001778)6.47494264
12tricarboxylic acid cycle (GO:0006099)6.41235394
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.35636018
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.28689647
15cardiac muscle cell development (GO:0055013)6.25548829
16regulation of skeletal muscle contraction (GO:0014819)6.17498277
17actin-mediated cell contraction (GO:0070252)6.06862473
18regulation of relaxation of muscle (GO:1901077)6.06554724
19regulation of actin filament-based movement (GO:1903115)6.02230592
20cardiac cell development (GO:0055006)5.86846085
21actomyosin structure organization (GO:0031032)5.86235459
22adult heart development (GO:0007512)5.79799837
23skeletal muscle fiber development (GO:0048741)5.78377807
24cardiac muscle tissue morphogenesis (GO:0055008)5.68358818
25ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.57132572
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.55574826
27striated muscle contraction (GO:0006941)5.48807168
28sarcoplasmic reticulum calcium ion transport (GO:0070296)5.47895248
29heart contraction (GO:0060047)5.47742712
30heart process (GO:0003015)5.47742712
31ventricular cardiac muscle cell action potential (GO:0086005)5.46732078
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.41982989
33bundle of His cell to Purkinje myocyte communication (GO:0086069)5.39762129
34cardiac muscle hypertrophy (GO:0003300)5.30962402
35skeletal muscle adaptation (GO:0043501)5.30817308
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.27750946
37myotube cell development (GO:0014904)5.17039713
38regulation of sarcomere organization (GO:0060297)5.16272422
39heart trabecula formation (GO:0060347)5.12877432
40muscle tissue morphogenesis (GO:0060415)5.11986855
41regulation of cell communication by electrical coupling (GO:0010649)5.10549599
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.07234931
43striated muscle hypertrophy (GO:0014897)5.05693427
44carnitine shuttle (GO:0006853)5.01217791
45regulation of striated muscle contraction (GO:0006942)4.94712306
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94076531
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.87471928
48glycogen catabolic process (GO:0005980)4.85917926
49regulation of acyl-CoA biosynthetic process (GO:0050812)4.80843028
50response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.67855206
51energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64805699
52ATP synthesis coupled proton transport (GO:0015986)4.64805699
53regulation of the force of heart contraction (GO:0002026)4.63524486
54muscle fiber development (GO:0048747)4.58740755
55respiratory electron transport chain (GO:0022904)4.56871092
56glucan catabolic process (GO:0009251)4.56622801
57actin filament-based movement (GO:0030048)4.53587510
58regulation of membrane repolarization (GO:0060306)4.51546845
59muscle hypertrophy (GO:0014896)4.47324040
60glucan biosynthetic process (GO:0009250)4.46570651
61glycogen biosynthetic process (GO:0005978)4.46570651
62electron transport chain (GO:0022900)4.43423927
63regulation of cofactor metabolic process (GO:0051193)4.36988821
64regulation of coenzyme metabolic process (GO:0051196)4.36988821
65skeletal muscle tissue development (GO:0007519)4.34615282
66creatine metabolic process (GO:0006600)4.31548209
67cell communication involved in cardiac conduction (GO:0086065)4.29210623
68muscle cell cellular homeostasis (GO:0046716)4.28389786
69cellular polysaccharide catabolic process (GO:0044247)4.27742635
70fatty acid transmembrane transport (GO:1902001)4.27091264
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.23040949
72positive regulation of myotube differentiation (GO:0010831)4.20725708
73NADH metabolic process (GO:0006734)4.19465506
74positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.11097511
75skeletal muscle tissue regeneration (GO:0043403)4.06401611
76oxidative phosphorylation (GO:0006119)4.04278759
77regulation of cardiac muscle cell contraction (GO:0086004)4.03014971
78regulation of cardiac muscle contraction (GO:0055117)4.02773016
79oxygen transport (GO:0015671)3.97843077
80striated muscle atrophy (GO:0014891)3.95624972
81skeletal muscle contraction (GO:0003009)3.95317675
82regulation of ATP catabolic process (GO:1903289)3.94857639
83regulation of ATPase activity (GO:0043462)3.94857639
84cardiac muscle hypertrophy in response to stress (GO:0014898)3.94532428
85muscle hypertrophy in response to stress (GO:0003299)3.94532428
86cardiac muscle adaptation (GO:0014887)3.94532428
872-oxoglutarate metabolic process (GO:0006103)3.92888970
88regulation of sequestering of triglyceride (GO:0010889)3.89336586
89regulation of heart rate (GO:0002027)3.88129310
90negative regulation of protein localization to cell surface (GO:2000009)3.86384884
91cardiac muscle cell action potential involved in contraction (GO:0086002)3.85914369
92polysaccharide catabolic process (GO:0000272)3.84913109
93negative regulation of potassium ion transport (GO:0043267)3.83341326
94muscle cell fate commitment (GO:0042693)3.81421045
95cardiac muscle cell action potential (GO:0086001)3.79912811
96negative regulation of calcium ion transmembrane transport (GO:1903170)3.77076370
97negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.77076370
98regulation of heart contraction (GO:0008016)3.68344454
99carnitine transmembrane transport (GO:1902603)3.68252644
100muscle contraction (GO:0006936)3.67558007
101muscle adaptation (GO:0043500)3.67075329
102positive regulation of cation channel activity (GO:2001259)3.66082307
103striated muscle cell development (GO:0055002)3.64938817
104muscle organ development (GO:0007517)3.64224954
105muscle structure development (GO:0061061)3.62962850
106cell communication by electrical coupling (GO:0010644)3.59876468
107gluconeogenesis (GO:0006094)3.58570983
108negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.58380911
109negative regulation of striated muscle cell apoptotic process (GO:0010664)3.57833467
110response to inactivity (GO:0014854)3.57037089
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.56579617
112relaxation of cardiac muscle (GO:0055119)3.56471134
113glycogen metabolic process (GO:0005977)3.55110717
114regulation of cardioblast differentiation (GO:0051890)3.54394890
115regulation of sulfur metabolic process (GO:0042762)3.53985056
116muscle atrophy (GO:0014889)3.53317793
117regulation of calcium ion transmembrane transport (GO:1903169)3.52912873
118regulation of calcium ion transmembrane transporter activity (GO:1901019)3.52912873
119positive regulation of heart rate (GO:0010460)3.52379501
120response to activity (GO:0014823)3.50924954
121striated muscle adaptation (GO:0014888)3.48704020
122glucan metabolic process (GO:0044042)3.48014047
123cellular glucan metabolic process (GO:0006073)3.48014047
124fructose metabolic process (GO:0006000)3.47125558
125positive regulation of heart contraction (GO:0045823)3.44154925
126muscle system process (GO:0003012)3.43489268
127muscle organ morphogenesis (GO:0048644)3.38049439
128cardiac conduction (GO:0061337)3.37119316
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36342803
130regulation of muscle contraction (GO:0006937)3.35331998
131myoblast fusion (GO:0007520)3.34758629
132amino-acid betaine transport (GO:0015838)3.34616184
133carnitine transport (GO:0015879)3.34616184
134regulation of muscle system process (GO:0090257)3.33966184
135muscle cell development (GO:0055001)3.33324956
136ventricular cardiac muscle cell development (GO:0055015)3.33045259
137regulation of myoblast differentiation (GO:0045661)3.24511899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.75974149
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.79114754
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.73658585
4TBX20_22080862_ChIP-Seq_HEART_Mouse4.16484093
5TBX20_22328084_ChIP-Seq_HEART_Mouse4.16484093
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.06633312
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.90863437
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.56912496
9ZNF263_19887448_ChIP-Seq_K562_Human3.14669598
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.04713083
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.98979615
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80268269
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.64663338
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.46228299
15* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.31970378
16EZH2_22144423_ChIP-Seq_EOC_Human2.22197135
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21154335
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02696341
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95948344
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90676659
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88215054
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88025411
23PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.80114144
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.68949943
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63891693
26* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.61632765
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58184527
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55531232
29CLOCK_20551151_ChIP-Seq_293T_Human1.55170346
30NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50039682
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49221705
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48489711
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42304743
34CTCF_27219007_Chip-Seq_Bcells_Human1.38746100
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38722797
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38639782
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36718875
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32732822
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29679740
40VDR_22108803_ChIP-Seq_LS180_Human1.28673175
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.25912806
42DROSHA_22980978_ChIP-Seq_HELA_Human1.25675461
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24926006
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24058721
45LXR_22292898_ChIP-Seq_THP-1_Human1.20899796
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.20314042
47KDM2B_26808549_Chip-Seq_DND41_Human1.18288629
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.17547452
49* TP63_22573176_ChIP-Seq_HFKS_Human1.16941105
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.16297279
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15579359
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13106131
53GATA1_19941826_ChIP-Seq_K562_Human1.12537933
54* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11581995
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10921649
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.08599893
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08217269
58IGF1R_20145208_ChIP-Seq_DFB_Human1.08191791
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06684882
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05678490
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04663221
62P68_20966046_ChIP-Seq_HELA_Human1.04394471
63SPI1_20517297_ChIP-Seq_HL60_Human1.02775209
64AR_21572438_ChIP-Seq_LNCaP_Human1.01366295
65RACK7_27058665_Chip-Seq_MCF-7_Human1.00231080
66ELK3_25401928_ChIP-Seq_HUVEC_Human0.99379664
67ATF3_27146783_Chip-Seq_COLON_Human0.99346366
68RXR_22158963_ChIP-Seq_LIVER_Mouse0.97865585
69RUNX1_27514584_Chip-Seq_MCF-7_Human0.97301798
70* MYC_27129775_Chip-Seq_CORNEA_Mouse0.96886418
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96494125
72GATA1_22025678_ChIP-Seq_K562_Human0.95677997
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94543417
74ISL1_27105846_Chip-Seq_CPCs_Mouse0.94081601
75* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93063107
76* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92820089
77ZNF274_21170338_ChIP-Seq_K562_Hela0.92347277
78* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89434559
79* OCT4_20526341_ChIP-Seq_ESCs_Human0.89303962
80CBX2_27304074_Chip-Seq_ESCs_Mouse0.88889175
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88833407
82GATA1_19941827_ChIP-Seq_MEL_Mouse0.88802356
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88733494
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88088463
85FOXH1_21741376_ChIP-Seq_ESCs_Human0.87239866
86BCL6_27268052_Chip-Seq_Bcells_Human0.86138752
87ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85759485
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85397261
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85209422
90GATA2_19941826_ChIP-Seq_K562_Human0.84971756
91* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84796504
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.84458138
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84366012
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84323613
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84230597
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84109250
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84057720
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83591152
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83430777
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83192416
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83045702
102BCOR_27268052_Chip-Seq_Bcells_Human0.82846808
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82460351
104YY1_22570637_ChIP-Seq_MALME-3M_Human0.82316171
105CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81108190
106CRX_20693478_ChIP-Seq_RETINA_Mouse0.81068089
107CTCF_21964334_Chip-Seq_Bcells_Human0.81004293
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80258496
109PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79929464
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79777971
111SPI1_23127762_ChIP-Seq_K562_Human0.79457400
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.78020650
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77686947
114STAT1_20625510_ChIP-Seq_HELA_Human0.77455454
115TDRD3_21172665_ChIP-Seq_MCF-7_Human0.77389600
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77208714
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.76475823
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.76274881
119E2F1_20622854_ChIP-Seq_HELA_Human0.76053479
120SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75902490
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75277173
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75106326
123EGR1_19032775_ChIP-ChIP_M12_Human0.74741669
124SMC4_20622854_ChIP-Seq_HELA_Human0.73523216
125HTT_18923047_ChIP-ChIP_STHdh_Human0.73430013
126CREB1_26743006_Chip-Seq_LNCaP_Human0.73020932
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72224760
128SA1_27219007_Chip-Seq_Bcells_Human0.72187301
129GATA6_21074721_ChIP-Seq_CACO-2_Human0.71952905
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.71221650
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70680715
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.70503615
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.70075894
134DPY_21335234_ChIP-Seq_ESCs_Mouse0.69781839
135CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69410001
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69123805
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.67962760
138RNF2_18974828_ChIP-Seq_MESCs_Mouse0.67962760
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66733069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.30501729
2MP0003646_muscle_fatigue6.11241887
3MP0004084_abnormal_cardiac_muscle5.60772310
4MP0000751_myopathy5.27515001
5MP0004215_abnormal_myocardial_fiber4.60062847
6MP0004036_abnormal_muscle_relaxation4.34936026
7MP0000749_muscle_degeneration4.10928573
8MP0005330_cardiomyopathy3.86886761
9MP0004087_abnormal_muscle_fiber3.11421939
10MP0002972_abnormal_cardiac_muscle3.10677123
11MP0003137_abnormal_impulse_conducting2.82664962
12MP0000750_abnormal_muscle_regeneration2.76027748
13MP0008775_abnormal_heart_ventricle2.72021073
14MP0005620_abnormal_muscle_contractility2.71003487
15MP0002106_abnormal_muscle_physiology2.60052298
16MP0004130_abnormal_muscle_cell2.55068598
17MP0010630_abnormal_cardiac_muscle2.51384060
18* MP0001544_abnormal_cardiovascular_syste2.49360673
19* MP0005385_cardiovascular_system_phenoty2.49360673
20MP0004145_abnormal_muscle_electrophysio2.44653367
21MP0004484_altered_response_of2.43730688
22MP0006138_congestive_heart_failure2.41383353
23MP0002269_muscular_atrophy2.40485909
24MP0003828_pulmonary_edema2.18648002
25MP0005369_muscle_phenotype2.12275033
26MP0000747_muscle_weakness2.09322579
27MP0000759_abnormal_skeletal_muscle2.09043386
28MP0004085_abnormal_heartbeat2.05085849
29MP0003221_abnormal_cardiomyocyte_apopto1.94375550
30MP0006036_abnormal_mitochondrial_physio1.84114767
31MP0004233_abnormal_muscle_weight1.78010910
32MP0004510_myositis1.65014620
33MP0002127_abnormal_cardiovascular_syste1.57781316
34MP0003950_abnormal_plasma_membrane1.51506444
35MP0005666_abnormal_adipose_tissue1.48317042
36MP0002332_abnormal_exercise_endurance1.45993390
37MP0005670_abnormal_white_adipose1.37874906
38MP0004270_analgesia1.21563126
39MP0002234_abnormal_pharynx_morphology1.18500161
40MP0000343_altered_response_to1.18252122
41MP0000266_abnormal_heart_morphology1.09468057
42MP0004185_abnormal_adipocyte_glucose1.08968766
43MP0003567_abnormal_fetal_cardiomyocyte1.07705211
44MP0005165_increased_susceptibility_to1.04453906
45MP0003279_aneurysm1.03444071
46MP0006035_abnormal_mitochondrial_morpho1.02471768
47MP0005375_adipose_tissue_phenotype1.02056722
48MP0010368_abnormal_lymphatic_system1.00455549
49MP0002108_abnormal_muscle_morphology0.92064293
50MP0005266_abnormal_metabolism0.86585217
51MP0000230_abnormal_systemic_arterial0.83398361
52MP0002909_abnormal_adrenal_gland0.79400462
53MP0001661_extended_life_span0.78893644
54MP0004043_abnormal_pH_regulation0.78221198
55* MP0002128_abnormal_blood_circulation0.69842748
56MP0003806_abnormal_nucleotide_metabolis0.68774138
57MP0005623_abnormal_meninges_morphology0.66581280
58MP0000013_abnormal_adipose_tissue0.63009803
59MP0001879_abnormal_lymphatic_vessel0.61893421
60MP0003566_abnormal_cell_adhesion0.60944372
61MP0000733_abnormal_muscle_development0.59527303
62MP0000003_abnormal_adipose_tissue0.58691371
63MP0003045_fibrosis0.56998531
64MP0003705_abnormal_hypodermis_morpholog0.56838664
65MP0000767_abnormal_smooth_muscle0.55611849
66MP0004147_increased_porphyrin_level0.54878109
67MP0002971_abnormal_brown_adipose0.54636645
68MP0002078_abnormal_glucose_homeostasis0.53170418
69MP0005319_abnormal_enzyme/_coenzyme0.49988176
70MP0005451_abnormal_body_composition0.47550310
71MP0000372_irregular_coat_pigmentation0.47441527
72MP0005187_abnormal_penis_morphology0.47369898
73MP0001299_abnormal_eye_distance/0.45046706
74MP0003656_abnormal_erythrocyte_physiolo0.43589692
75MP0008961_abnormal_basal_metabolism0.41461666
76MP0008438_abnormal_cutaneous_collagen0.39896187
77MP0003879_abnormal_hair_cell0.39294352
78MP0002925_abnormal_cardiovascular_devel0.38891673
79MP0005535_abnormal_body_temperature0.37613166
80MP0002822_catalepsy0.37227472
81MP0010030_abnormal_orbit_morphology0.36642419
82MP0002638_abnormal_pupillary_reflex0.35661402
83MP0009840_abnormal_foam_cell0.35507864
84MP0005275_abnormal_skin_tensile0.35030897
85MP0003195_calcinosis0.34716697
86MP0004134_abnormal_chest_morphology0.34526462
87MP0004272_abnormal_basement_membrane0.33135565
88MP0005083_abnormal_biliary_tract0.33023205
89MP0000762_abnormal_tongue_morphology0.31813989
90MP0005334_abnormal_fat_pad0.31328192
91MP0005166_decreased_susceptibility_to0.31246565
92MP0005332_abnormal_amino_acid0.31000919
93MP0003984_embryonic_growth_retardation0.30900304
94MP0003948_abnormal_gas_homeostasis0.30250297
95MP0001614_abnormal_blood_vessel0.30039250
96MP0002877_abnormal_melanocyte_morpholog0.29941728
97MP0001784_abnormal_fluid_regulation0.29622634
98MP0002088_abnormal_embryonic_growth/wei0.29443234
99MP0002896_abnormal_bone_mineralization0.29329285
100MP0009780_abnormal_chondrocyte_physiolo0.29324705
101MP0005386_behavior/neurological_phenoty0.28952272
102MP0004924_abnormal_behavior0.28952272
103MP0005452_abnormal_adipose_tissue0.27973182
104MP0002118_abnormal_lipid_homeostasis0.27110183
105MP0005423_abnormal_somatic_nervous0.25721168
106MP0001727_abnormal_embryo_implantation0.24796972
107MP0005595_abnormal_vascular_smooth0.24095163
108MP0002114_abnormal_axial_skeleton0.24011477
109MP0002295_abnormal_pulmonary_circulatio0.23884994
110MP0004142_abnormal_muscle_tone0.23864598
111MP0001346_abnormal_lacrimal_gland0.23844038
112MP0000249_abnormal_blood_vessel0.23450951
113MP0005584_abnormal_enzyme/coenzyme_acti0.22370687
114MP0005167_abnormal_blood-brain_barrier0.22202986
115MP0009115_abnormal_fat_cell0.22081553
116MP0003011_delayed_dark_adaptation0.21745394
117MP0008569_lethality_at_weaning0.20589713
118MP0009672_abnormal_birth_weight0.19224553
119MP0005376_homeostasis/metabolism_phenot0.18930009
120MP0001853_heart_inflammation0.18008461
121MP0002734_abnormal_mechanical_nocicepti0.17954660
122MP0008874_decreased_physiological_sensi0.17716930
123MP0001943_abnormal_respiration0.17505018
124MP0002066_abnormal_motor_capabilities/c0.17390149
125MP0009250_abnormal_appendicular_skeleto0.16852552

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.68863747
2Ventricular tachycardia (HP:0004756)6.94831974
3Calf muscle hypertrophy (HP:0008981)6.80303458
4Muscle hypertrophy of the lower extremities (HP:0008968)6.32592341
5Exercise-induced myalgia (HP:0003738)6.11040967
6Exercise-induced muscle cramps (HP:0003710)6.09445636
7Muscle fiber splitting (HP:0003555)5.96677679
8Atrial fibrillation (HP:0005110)5.88103231
9Primary atrial arrhythmia (HP:0001692)5.50323143
10Abnormality of the calf musculature (HP:0001430)5.40443945
11Distal arthrogryposis (HP:0005684)5.37166790
12Supraventricular tachycardia (HP:0004755)5.32305643
13Myopathic facies (HP:0002058)5.30424573
14Hyporeflexia of lower limbs (HP:0002600)5.25587481
15Lipoatrophy (HP:0100578)5.24322881
16Supraventricular arrhythmia (HP:0005115)5.20944485
17Abnormality of the left ventricular outflow tract (HP:0011103)5.16102637
18Subaortic stenosis (HP:0001682)5.16102637
19Myoglobinuria (HP:0002913)4.81312170
20Right ventricular cardiomyopathy (HP:0011663)4.67890800
21Bundle branch block (HP:0011710)4.67073145
22Round ear (HP:0100830)4.62989061
23Centrally nucleated skeletal muscle fibers (HP:0003687)4.50312770
24EMG: myopathic abnormalities (HP:0003458)4.45624256
25Dilated cardiomyopathy (HP:0001644)4.38571520
26Palpitations (HP:0001962)4.37715842
27Syncope (HP:0001279)4.37459222
28Asymmetric septal hypertrophy (HP:0001670)4.30573929
29Ulnar deviation of the wrist (HP:0003049)4.29159539
30Prolonged QT interval (HP:0001657)4.10437587
31Increased connective tissue (HP:0009025)4.05805842
32Heart block (HP:0012722)3.80050728
33Difficulty running (HP:0009046)3.78181831
34Ventricular arrhythmia (HP:0004308)3.74491998
35Calcaneovalgus deformity (HP:0001848)3.74330648
36Rhabdomyolysis (HP:0003201)3.66724998
37Abnormal atrioventricular conduction (HP:0005150)3.58960804
38Myotonia (HP:0002486)3.58460973
39Atrioventricular block (HP:0001678)3.54683903
40Acute necrotizing encephalopathy (HP:0006965)3.46030083
41Abnormal mitochondria in muscle tissue (HP:0008316)3.42901015
42Ventricular fibrillation (HP:0001663)3.39842107
43Deformed tarsal bones (HP:0008119)3.31361643
44Absent phalangeal crease (HP:0006109)3.30480087
45Frequent falls (HP:0002359)3.19787274
46Hepatic necrosis (HP:0002605)3.17172093
47Difficulty climbing stairs (HP:0003551)3.01468893
48Acute encephalopathy (HP:0006846)2.97959173
49Abnormal EKG (HP:0003115)2.97369684
50Left ventricular hypertrophy (HP:0001712)2.95254675
51Malignant hyperthermia (HP:0002047)2.90744445
52Progressive macrocephaly (HP:0004481)2.86514710
53Hepatocellular necrosis (HP:0001404)2.85034943
54Distal lower limb muscle weakness (HP:0009053)2.80581266
55Mitochondrial inheritance (HP:0001427)2.78669981
56Ketoacidosis (HP:0001993)2.76419690
57Abnormal finger flexion creases (HP:0006143)2.72657061
58Muscle fiber inclusion bodies (HP:0100299)2.68114910
59Areflexia of lower limbs (HP:0002522)2.67494094
60Type 1 muscle fiber predominance (HP:0003803)2.66883819
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64969072
62Increased variability in muscle fiber diameter (HP:0003557)2.64687063
63Cerebral edema (HP:0002181)2.63644025
64Muscle stiffness (HP:0003552)2.62762004
65Palmoplantar keratoderma (HP:0000982)2.60975965
66Limb-girdle muscle atrophy (HP:0003797)2.57654810
67Testicular atrophy (HP:0000029)2.56448049
68Weak cry (HP:0001612)2.56080037
69Increased CSF lactate (HP:0002490)2.55371215
70Bulbar palsy (HP:0001283)2.54207425
71Hypoglycemic coma (HP:0001325)2.51983975
72Neck muscle weakness (HP:0000467)2.51665372
73Abnormality of skeletal muscle fiber size (HP:0012084)2.47758152
74Scapular winging (HP:0003691)2.45822571
75Increased muscle lipid content (HP:0009058)2.45677763
76Progressive muscle weakness (HP:0003323)2.37124986
77Exercise intolerance (HP:0003546)2.34922693
78Conjunctival hamartoma (HP:0100780)2.30665502
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28859743
80Dicarboxylic aciduria (HP:0003215)2.28859743
81Ragged-red muscle fibers (HP:0003200)2.27638002
82Respiratory failure (HP:0002878)2.26851694
83Fatigable weakness (HP:0003473)2.26781418
84Abnormality of the neuromuscular junction (HP:0003398)2.26781418
85Abnormality of fatty-acid metabolism (HP:0004359)2.25474164
86Lactic acidosis (HP:0003128)2.20882896
87Fetal akinesia sequence (HP:0001989)2.19246452
88Pheochromocytoma (HP:0002666)2.17262736
89Slender build (HP:0001533)2.16853596
90Increased intramyocellular lipid droplets (HP:0012240)2.15198547
91Rimmed vacuoles (HP:0003805)2.14836533
92Lower limb amyotrophy (HP:0007210)2.12457137
93Proximal amyotrophy (HP:0007126)2.11306711
94Abnormality of the calcaneus (HP:0008364)2.10836663
95Abnormality of the foot musculature (HP:0001436)2.09837411
96Hip contracture (HP:0003273)2.07930142
97Distal lower limb amyotrophy (HP:0008944)2.07746245
98Ketosis (HP:0001946)2.07232313
99Spinal rigidity (HP:0003306)2.04285077
100Muscular dystrophy (HP:0003560)2.03484181
101Large for gestational age (HP:0001520)2.02030157
102EMG: neuropathic changes (HP:0003445)2.01162538
103Foot dorsiflexor weakness (HP:0009027)2.01020798
104Mildly elevated creatine phosphokinase (HP:0008180)2.00149284
105Hyperkalemia (HP:0002153)1.99482684
106Gowers sign (HP:0003391)1.98150566
107Hyperinsulinemic hypoglycemia (HP:0000825)1.97266093
108Waddling gait (HP:0002515)1.97083003
109Congestive heart failure (HP:0001635)1.96725337
110Abnormality of the shoulder girdle musculature (HP:0001435)1.95281585
111Neuroendocrine neoplasm (HP:0100634)1.95086861
112Neoplasm of head and neck (HP:0012288)1.94352128
113Esophageal neoplasm (HP:0100751)1.94352128
114Nemaline bodies (HP:0003798)1.94046411
115Sudden cardiac death (HP:0001645)1.94016101
116Hypoplastic ischia (HP:0003175)1.90711456
117Hamartoma of the eye (HP:0010568)1.89202259
118Dysmetric saccades (HP:0000641)1.87795202
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83428197
120Abnormality of alanine metabolism (HP:0010916)1.83428197
121Hyperalaninemia (HP:0003348)1.83428197
122Facial diplegia (HP:0001349)1.83102094
123Respiratory insufficiency due to muscle weakness (HP:0002747)1.82629740
124Generalized muscle weakness (HP:0003324)1.79496564
125Neoplasm of the adrenal gland (HP:0100631)1.75208538
126Tinnitus (HP:0000360)1.73821417
127Congenital malformation of the right heart (HP:0011723)1.72954735
128Double outlet right ventricle (HP:0001719)1.72954735
129Limb-girdle muscle weakness (HP:0003325)1.67161587
130Popliteal pterygium (HP:0009756)1.66131460
131Type 2 muscle fiber atrophy (HP:0003554)1.59286068
132Nonprogressive disorder (HP:0003680)1.55363955
133Abnormality of the hip-girdle musculature (HP:0001445)1.54290042
134Abnormality of the musculature of the pelvis (HP:0001469)1.54290042
135Metatarsus adductus (HP:0001840)1.53038044
136Muscle fiber atrophy (HP:0100295)1.49496662
137Steppage gait (HP:0003376)1.44964174
138Shoulder girdle muscle weakness (HP:0003547)1.43374869
139Pelvic girdle muscle weakness (HP:0003749)1.42760737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.63182574
2PHKG24.29025739
3PHKG14.29025739
4OBSCN4.12399324
5MYLK3.90779582
6LMTK23.85604475
7PDK43.30331206
8PDK33.30331206
9DMPK2.98749238
10BCKDK2.70303879
11PKN22.58637920
12MUSK2.55425496
13TRIB32.51147063
14PIK3CA2.31969927
15PINK12.18437726
16NEK12.16969716
17PDK21.97293624
18TIE11.90877792
19STK241.58448805
20PAK31.53608074
21GRK71.46117783
22PRKD11.34434587
23CAMK2D1.26325719
24CDC42BPA1.23062769
25LIMK11.06794179
26MARK11.06750784
27MAPK121.05322834
28MAP3K71.04565218
29ILK1.02776399
30ROCK11.02158811
31MAPKAPK30.99946697
32STK40.99892009
33PKN10.97984452
34WNK40.97688855
35MOS0.95217118
36CCNB10.94307376
37DAPK30.93445206
38MAP2K30.93438537
39INSRR0.90348884
40PRKAA10.88949529
41MAP3K50.87167496
42EEF2K0.86304269
43NME10.84995255
44RIPK10.84742255
45STK38L0.83088220
46FLT30.82744464
47PRKAA20.80734998
48ZAK0.78905816
49TRPM70.74612019
50PDGFRA0.73280650
51CAMK40.70785460
52DYRK1B0.67270355
53RPS6KC10.66629099
54RPS6KL10.66629099
55MAP3K30.64840472
56STK380.64099774
57ERBB30.63851166
58ROCK20.63793158
59CAMK2A0.59147284
60EPHB10.58818506
61RPS6KA60.57936798
62NME20.56405921
63WNK10.55974564
64TGFBR20.55068850
65MAPK40.54072616
66PRKACB0.52590780
67MAP2K10.52086426
68KDR0.51365391
69MAP3K130.50105327
70CAMK2B0.49502719
71PRKCE0.47004474
72CAMK10.45262085
73PTK2B0.43590452
74PRKACA0.41531843
75PRKD30.39772541
76PRKACG0.39027476
77NEK90.38317074
78PDPK10.37764111
79CAMK2G0.37659099
80KSR20.36064799
81ICK0.35596730
82AKT20.35508592
83PRKCH0.34854076
84MAPKAPK50.31760830
85PIK3CG0.31075226
86MAP3K60.28762869
87SIK10.28402583
88PTK60.28199849
89PDK10.27909437
90TBK10.27711756
91RPS6KA10.26916651
92STK390.25444562
93SGK20.23884255
94TAOK20.23273470
95FER0.20974560
96PRKG20.20963291
97MAP2K40.20887705
98MAPK100.20727317
99EPHB20.20427633
100SGK30.20110984
101JAK10.20011801
102PRKG10.19814671
103ARAF0.19180738
104MAP3K10.19023327
105MTOR0.19006191
106RPS6KA20.18699188
107MARK20.18697220
108SGK10.17849959
109PRPF4B0.17621434
110TAOK10.17399898
111RPS6KA30.16404173
112CDK80.15873727
113MAPK110.15773012
114RPS6KB10.15495938
115MAP2K60.15229182
116ZAP700.14119907
117LATS20.13617325
118RPS6KB20.13598304
119RET0.11308024
120MAPK70.10738676
121FGFR40.10729244
122EPHA30.10297133
123DAPK20.09746795
124MAPK130.09683333
125MAPKAPK20.09611501
126MARK30.09132949
127MAP3K110.09066440
128MAP3K40.08181335
129SGK4940.06627378
130SGK2230.06627378
131PAK60.06619999

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.80616400
2* Cardiac muscle contraction_Homo sapiens_hsa042604.32483956
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.18657609
4Dilated cardiomyopathy_Homo sapiens_hsa054143.75362352
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.67634068
6Parkinsons disease_Homo sapiens_hsa050123.55035356
7* Oxidative phosphorylation_Homo sapiens_hsa001903.54507711
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46615591
9Propanoate metabolism_Homo sapiens_hsa006403.22015403
10Fatty acid degradation_Homo sapiens_hsa000712.67310261
11Alzheimers disease_Homo sapiens_hsa050102.64781516
12Carbon metabolism_Homo sapiens_hsa012002.41577429
13* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41550213
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.37546277
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24909957
16Huntingtons disease_Homo sapiens_hsa050162.21922990
17Fatty acid metabolism_Homo sapiens_hsa012122.01321497
18Viral myocarditis_Homo sapiens_hsa054161.82336423
19Pyruvate metabolism_Homo sapiens_hsa006201.81139664
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71582197
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48510064
22Butanoate metabolism_Homo sapiens_hsa006501.41435762
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22417404
24Fatty acid elongation_Homo sapiens_hsa000621.21054129
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14636492
26Biosynthesis of amino acids_Homo sapiens_hsa012301.07343279
27Starch and sucrose metabolism_Homo sapiens_hsa005001.05922326
28PPAR signaling pathway_Homo sapiens_hsa033201.05142326
29Insulin resistance_Homo sapiens_hsa049311.03461711
30Glucagon signaling pathway_Homo sapiens_hsa049221.02402923
31Adipocytokine signaling pathway_Homo sapiens_hsa049200.95683423
32cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95280332
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92413616
34Insulin signaling pathway_Homo sapiens_hsa049100.88345712
35Tryptophan metabolism_Homo sapiens_hsa003800.81021768
36Arginine biosynthesis_Homo sapiens_hsa002200.75772943
37Calcium signaling pathway_Homo sapiens_hsa040200.74853287
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74123732
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73059354
40Arginine and proline metabolism_Homo sapiens_hsa003300.72115331
41beta-Alanine metabolism_Homo sapiens_hsa004100.71745894
42Lysine degradation_Homo sapiens_hsa003100.69980890
43Long-term potentiation_Homo sapiens_hsa047200.67648061
44Type II diabetes mellitus_Homo sapiens_hsa049300.66249310
45AMPK signaling pathway_Homo sapiens_hsa041520.64704723
46Nitrogen metabolism_Homo sapiens_hsa009100.64481841
47Focal adhesion_Homo sapiens_hsa045100.62527029
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62079456
49HIF-1 signaling pathway_Homo sapiens_hsa040660.61921376
50Galactose metabolism_Homo sapiens_hsa000520.61228988
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.58190775
52Oxytocin signaling pathway_Homo sapiens_hsa049210.57551211
53Phenylalanine metabolism_Homo sapiens_hsa003600.56046342
54Peroxisome_Homo sapiens_hsa041460.52294239
55Tight junction_Homo sapiens_hsa045300.48759423
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47582537
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46403411
58Fructose and mannose metabolism_Homo sapiens_hsa000510.45389486
59Insulin secretion_Homo sapiens_hsa049110.44626477
60Fatty acid biosynthesis_Homo sapiens_hsa000610.43032716
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42051379
62Histidine metabolism_Homo sapiens_hsa003400.41769208
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.41123012
64Renin secretion_Homo sapiens_hsa049240.39391432
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38755428
66cAMP signaling pathway_Homo sapiens_hsa040240.38139433
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37127492
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35837787
69Gastric acid secretion_Homo sapiens_hsa049710.35148203
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34011552
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33529570
72ECM-receptor interaction_Homo sapiens_hsa045120.32319355
73Salivary secretion_Homo sapiens_hsa049700.31947218
74Circadian rhythm_Homo sapiens_hsa047100.29723023
75* Metabolic pathways_Homo sapiens_hsa011000.28948913
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27628623
77Amphetamine addiction_Homo sapiens_hsa050310.27577195
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25578488
79Amoebiasis_Homo sapiens_hsa051460.24626540
80Adherens junction_Homo sapiens_hsa045200.21731642
81Fat digestion and absorption_Homo sapiens_hsa049750.20492793
82Regulation of autophagy_Homo sapiens_hsa041400.20491425
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.20240393
84Circadian entrainment_Homo sapiens_hsa047130.20052304
85Sulfur relay system_Homo sapiens_hsa041220.18426095
86Tyrosine metabolism_Homo sapiens_hsa003500.16395085
87Renal cell carcinoma_Homo sapiens_hsa052110.15928995
88Melanogenesis_Homo sapiens_hsa049160.15430735
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15159622
90Long-term depression_Homo sapiens_hsa047300.14020190
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.11934806
92GnRH signaling pathway_Homo sapiens_hsa049120.11408866
93VEGF signaling pathway_Homo sapiens_hsa043700.10817600
94Pancreatic secretion_Homo sapiens_hsa049720.10562649
95Gap junction_Homo sapiens_hsa045400.10266232
96Ovarian steroidogenesis_Homo sapiens_hsa049130.10027837
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09843723
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09757779
99Platelet activation_Homo sapiens_hsa046110.09622306
100Purine metabolism_Homo sapiens_hsa002300.09309636
101Dorso-ventral axis formation_Homo sapiens_hsa043200.07686837
102Cholinergic synapse_Homo sapiens_hsa047250.07298194
103Taste transduction_Homo sapiens_hsa047420.07232408
104Proteoglycans in cancer_Homo sapiens_hsa052050.06304660
105Sulfur metabolism_Homo sapiens_hsa009200.06032034
106Phototransduction_Homo sapiens_hsa047440.05669434
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.04918932
108FoxO signaling pathway_Homo sapiens_hsa040680.02569053
109mTOR signaling pathway_Homo sapiens_hsa041500.02419619
110Bile secretion_Homo sapiens_hsa049760.02372210
111Glycerolipid metabolism_Homo sapiens_hsa005610.02113527
112Pentose phosphate pathway_Homo sapiens_hsa00030-0.0182732
113Notch signaling pathway_Homo sapiens_hsa04330-0.0116625
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0095860
115Toxoplasmosis_Homo sapiens_hsa05145-0.0082128
116MAPK signaling pathway_Homo sapiens_hsa04010-0.0076020

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