COX6B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.38741412
2* respiratory electron transport chain (GO:0022904)8.71074666
3* electron transport chain (GO:0022900)8.48965974
4ATP biosynthetic process (GO:0006754)5.81756661
5chaperone-mediated protein transport (GO:0072321)5.42638023
6purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.31561474
7* hydrogen ion transmembrane transport (GO:1902600)5.26451599
8purine nucleoside triphosphate biosynthetic process (GO:0009145)5.21706445
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.07869419
10protein complex biogenesis (GO:0070271)4.94569560
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.93807054
12NADH dehydrogenase complex assembly (GO:0010257)4.93807054
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.93807054
14oxidative phosphorylation (GO:0006119)4.82553043
15inner mitochondrial membrane organization (GO:0007007)4.79904343
16ribonucleoside triphosphate biosynthetic process (GO:0009201)4.61995900
17* proton transport (GO:0015992)4.59752789
18* hydrogen transport (GO:0006818)4.51914737
19viral transcription (GO:0019083)4.49761262
20mitochondrial respiratory chain complex assembly (GO:0033108)4.48730801
21protein neddylation (GO:0045116)4.43522802
22ribosomal small subunit biogenesis (GO:0042274)4.38839569
23translational termination (GO:0006415)4.27508170
24nuclear-transcribed mRNA catabolic process (GO:0000956)4.23483350
25mRNA catabolic process (GO:0006402)4.01236296
26cellular component biogenesis (GO:0044085)3.96545669
27termination of RNA polymerase III transcription (GO:0006386)3.91366518
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.91366518
29nucleoside triphosphate biosynthetic process (GO:0009142)3.89518445
30cotranslational protein targeting to membrane (GO:0006613)3.85101681
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.80772063
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80046634
33protein targeting to ER (GO:0045047)3.77565544
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74242746
35ribonucleoprotein complex biogenesis (GO:0022613)3.73949746
36sequestering of actin monomers (GO:0042989)3.66933853
37RNA catabolic process (GO:0006401)3.64814484
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64355437
39protein localization to endoplasmic reticulum (GO:0070972)3.60813416
40GTP biosynthetic process (GO:0006183)3.55878318
41mitochondrial transport (GO:0006839)3.53667966
42establishment of protein localization to membrane (GO:0090150)3.53207686
43regulation of cellular amino acid metabolic process (GO:0006521)3.50819198
44regulation of mitochondrial translation (GO:0070129)3.48564271
45regulation of oxidative phosphorylation (GO:0002082)3.48073524
46ATP hydrolysis coupled proton transport (GO:0015991)3.47906736
47energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.47906736
48protein targeting (GO:0006605)3.45468596
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45157763
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45141746
51negative regulation of ligase activity (GO:0051352)3.45141746
52aerobic respiration (GO:0009060)3.44883572
53cellular protein complex disassembly (GO:0043624)3.44084955
54translational elongation (GO:0006414)3.42521592
55tricarboxylic acid cycle (GO:0006099)3.38482865
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37158446
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32555597
58viral life cycle (GO:0019058)3.32012315
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26798643
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26798643
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26478700
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26478700
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26478700
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21240602
65purine nucleoside monophosphate biosynthetic process (GO:0009127)3.19987598
66purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.19987598
67protein targeting to mitochondrion (GO:0006626)3.18981394
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16805778
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.16805778
70* generation of precursor metabolites and energy (GO:0006091)3.14891746
71establishment of protein localization to mitochondrion (GO:0072655)3.14825849
72establishment of protein localization to organelle (GO:0072594)3.13310813
73respiratory chain complex IV assembly (GO:0008535)3.12568342
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.11280957
75rRNA modification (GO:0000154)3.10629565
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10477729
77rRNA processing (GO:0006364)3.06266612
78protein localization to mitochondrion (GO:0070585)3.04044073
79neuron cell-cell adhesion (GO:0007158)3.02118084
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01287485
81fatty acid elongation (GO:0030497)3.00312978
82nucleoside monophosphate biosynthetic process (GO:0009124)2.99717909
83NADH metabolic process (GO:0006734)2.95288578
84RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95049481
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95049481
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94615536
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94155849
88regulation of cellular respiration (GO:0043457)2.92739295
89rRNA metabolic process (GO:0016072)2.92736975
90spliceosomal snRNP assembly (GO:0000387)2.92417875
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.91145991
92positive regulation of ligase activity (GO:0051351)2.88092138
93* substantia nigra development (GO:0021762)2.86463677
94quinone biosynthetic process (GO:1901663)2.86143317
95ubiquinone biosynthetic process (GO:0006744)2.86143317
96base-excision repair, AP site formation (GO:0006285)2.86069917
97ribosomal small subunit assembly (GO:0000028)2.84580764
98UTP biosynthetic process (GO:0006228)2.84450827
99calcium-mediated signaling using intracellular calcium source (GO:0035584)2.83298535
100axon ensheathment in central nervous system (GO:0032291)2.82676511
101central nervous system myelination (GO:0022010)2.82676511
102purine nucleoside biosynthetic process (GO:0042451)2.82310101
103purine ribonucleoside biosynthetic process (GO:0046129)2.82310101
104dopamine transport (GO:0015872)2.82245101
105regulation of acyl-CoA biosynthetic process (GO:0050812)2.79631772
106cellular response to epinephrine stimulus (GO:0071872)2.79379737
107succinate metabolic process (GO:0006105)2.78693516
108cytochrome complex assembly (GO:0017004)2.78092577
109regulation of cell communication by electrical coupling (GO:0010649)2.77996189
110cellular ketone body metabolic process (GO:0046950)2.77280816
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75197303
112translation (GO:0006412)2.75089993
113translational initiation (GO:0006413)2.73523384
114intracellular protein transmembrane import (GO:0044743)2.71973302
115response to epinephrine (GO:0071871)2.69631864
116cellular respiration (GO:0045333)2.68958275
117ubiquinone metabolic process (GO:0006743)2.68055834
118protein complex disassembly (GO:0043241)2.67541702
119UTP metabolic process (GO:0046051)2.62938285
120protein targeting to membrane (GO:0006612)2.62113183
121ribosomal large subunit biogenesis (GO:0042273)2.59690041
122macromolecular complex disassembly (GO:0032984)2.56954577
123maturation of SSU-rRNA (GO:0030490)2.54279094
124proteasome assembly (GO:0043248)2.54054214
125regulation of cofactor metabolic process (GO:0051193)2.52892010
126regulation of coenzyme metabolic process (GO:0051196)2.52892010
127regulation of dopamine metabolic process (GO:0042053)2.52748986
128regulation of catecholamine metabolic process (GO:0042069)2.52748986
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47087641
130protein-cofactor linkage (GO:0018065)2.46397778
131ketone body metabolic process (GO:1902224)2.46150929
132ribonucleoside monophosphate biosynthetic process (GO:0009156)2.43945704
133regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.43671905
134regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.41442089
135negative regulation of protein localization to cell surface (GO:2000009)2.41316686
136positive regulation of action potential (GO:0045760)2.37391589
137positive regulation of synapse assembly (GO:0051965)2.36920296
138mitochondrial ATP synthesis coupled proton transport (GO:0042776)11.5082089
139energy coupled proton transport, down electrochemical gradient (GO:0015985)10.6926877
140ATP synthesis coupled proton transport (GO:0015986)10.6926877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.83051021
2EZH2_22144423_ChIP-Seq_EOC_Human4.57141523
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37043360
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.14492573
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.11363004
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.87304431
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87289805
8XRN2_22483619_ChIP-Seq_HELA_Human2.66558270
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64057114
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56895646
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.51130071
12GBX2_23144817_ChIP-Seq_PC3_Human2.40002347
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38418833
14VDR_22108803_ChIP-Seq_LS180_Human2.38085526
15TAF15_26573619_Chip-Seq_HEK293_Human2.36048253
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30088573
17VDR_23849224_ChIP-Seq_CD4+_Human2.28356875
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27313916
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23110741
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22829977
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.18934515
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.16976604
23FOXP3_21729870_ChIP-Seq_TREG_Human2.13942186
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13465359
25ELK1_19687146_ChIP-ChIP_HELA_Human2.07587129
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99706270
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98375389
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98246615
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92286228
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.89814825
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88469242
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85461198
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85327767
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.85134559
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84168239
36GABP_19822575_ChIP-Seq_HepG2_Human1.83229877
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81702357
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76729957
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75084128
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70708401
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69857523
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69857523
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69318001
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66700361
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66209273
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65928550
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63496662
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.63416030
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62341528
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58578693
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57533828
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53976336
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52088818
54FUS_26573619_Chip-Seq_HEK293_Human1.51553360
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50736153
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50145916
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49257926
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48629766
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.48134365
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45610377
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44217841
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42358250
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42166592
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41906664
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.37058040
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35645389
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.33799172
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32518729
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32383198
70REST_21632747_ChIP-Seq_MESCs_Mouse1.31508700
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31455540
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30461726
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25064030
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24681178
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23392107
76ER_23166858_ChIP-Seq_MCF-7_Human1.22707938
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20957691
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20846371
79P300_19829295_ChIP-Seq_ESCs_Human1.20543629
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20366816
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19098683
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.17783495
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17669472
84ZNF274_21170338_ChIP-Seq_K562_Hela1.17159481
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.17108939
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16641105
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15544078
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15491967
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13091286
90KDM5A_27292631_Chip-Seq_BREAST_Human1.09756716
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09629624
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.09461963
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08873086
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08618367
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08237993
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.07291341
97HTT_18923047_ChIP-ChIP_STHdh_Human1.06833781
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06265623
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05793574
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.05682680
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04887833
102* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03162068
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02727088
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02072805
105DCP1A_22483619_ChIP-Seq_HELA_Human1.01731758
106RNF2_27304074_Chip-Seq_ESCs_Mouse1.00766310
107SMAD3_21741376_ChIP-Seq_EPCs_Human0.99426182
108EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99371174
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.98669948
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98525663
111AR_21572438_ChIP-Seq_LNCaP_Human0.97999260
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97698448
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97560760
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97132761
115IRF1_19129219_ChIP-ChIP_H3396_Human0.96740313
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.96607956
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96138173
118PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95825248
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94283087
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93782778
121SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93437393
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93055169
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.92330359
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.90241292
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89639401
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89460850
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89350973
128E2F7_22180533_ChIP-Seq_HELA_Human0.89181413
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88830734
130ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88419141
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87888541
132JUN_21703547_ChIP-Seq_K562_Human0.87602180
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87137529
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.87130779
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86050996
136SOX2_16153702_ChIP-ChIP_HESCs_Human0.86009536
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85605015
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83992148
139MYC_18555785_ChIP-Seq_MESCs_Mouse0.83750750
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83703344
141ZNF263_19887448_ChIP-Seq_K562_Human0.83575983
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83321320
143MYC_18940864_ChIP-ChIP_HL60_Human0.82246403
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.81528981
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81425759
146RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81155602
147MYCN_18555785_ChIP-Seq_MESCs_Mouse0.80571736
148MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80457710
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80081938
150BCAT_22108803_ChIP-Seq_LS180_Human0.79460104
151TTF2_22483619_ChIP-Seq_HELA_Human0.79383296
152RNF2_27304074_Chip-Seq_NSC_Mouse0.77996440
153PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77221054
154MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.76747167
155IGF1R_20145208_ChIP-Seq_DFB_Human0.75920877
156PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75327253
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75220221
158NANOG_19829295_ChIP-Seq_ESCs_Human0.75209070
159ERG_20517297_ChIP-Seq_VCAP_Human0.75098291
160SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.74123040
161* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72545497
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71983967
163BCL6_27268052_Chip-Seq_Bcells_Human0.71633444
164CIITA_25753668_ChIP-Seq_RAJI_Human0.70570653
165CTCF_20526341_ChIP-Seq_ESCs_Human0.69096475
166TP53_22573176_ChIP-Seq_HFKS_Human0.68953650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.66988256
2MP0003880_abnormal_central_pattern4.20800880
3MP0009379_abnormal_foot_pigmentation3.97978660
4MP0001529_abnormal_vocalization3.36952398
5MP0003186_abnormal_redox_activity2.93924646
6MP0006276_abnormal_autonomic_nervous2.69826618
7MP0004215_abnormal_myocardial_fiber2.62124448
8MP0000751_myopathy2.60908797
9MP0006036_abnormal_mitochondrial_physio2.38831150
10MP0006292_abnormal_olfactory_placode2.37769533
11MP0001905_abnormal_dopamine_level2.37480288
12MP0008058_abnormal_DNA_repair2.33499828
13MP0003646_muscle_fatigue2.33027820
14MP0010030_abnormal_orbit_morphology2.27111410
15MP0002736_abnormal_nociception_after2.17424750
16MP0000372_irregular_coat_pigmentation2.12802244
17MP0001968_abnormal_touch/_nociception2.11486512
18MP0002938_white_spotting2.08493869
19MP0004142_abnormal_muscle_tone2.06254336
20MP0009745_abnormal_behavioral_response2.05602098
21MP0008995_early_reproductive_senescence2.04409921
22MP0001440_abnormal_grooming_behavior2.02621400
23MP0002064_seizures1.95359341
24MP0004036_abnormal_muscle_relaxation1.91684806
25MP0002272_abnormal_nervous_system1.88899226
26MP0006035_abnormal_mitochondrial_morpho1.88080544
27MP0003123_paternal_imprinting1.86302385
28MP0003635_abnormal_synaptic_transmissio1.85659924
29MP0003718_maternal_effect1.85450808
30MP0009046_muscle_twitch1.81315420
31MP0003137_abnormal_impulse_conducting1.79187466
32MP0002822_catalepsy1.77072422
33MP0005330_cardiomyopathy1.76713430
34MP0002653_abnormal_ependyma_morphology1.75866887
35MP0004084_abnormal_cardiac_muscle1.74225331
36MP0004957_abnormal_blastocyst_morpholog1.74148821
37MP0002277_abnormal_respiratory_mucosa1.72875083
38MP0000749_muscle_degeneration1.71557501
39MP0002572_abnormal_emotion/affect_behav1.69827990
40MP0000566_synostosis1.65579590
41MP0001486_abnormal_startle_reflex1.60944645
42MP0008789_abnormal_olfactory_epithelium1.60940808
43MP0002734_abnormal_mechanical_nocicepti1.59393006
44MP0003786_premature_aging1.58960823
45MP0004043_abnormal_pH_regulation1.58545419
46MP0004270_analgesia1.56283362
47MP0005084_abnormal_gallbladder_morpholo1.55445647
48MP0003693_abnormal_embryo_hatching1.50968917
49MP0003329_amyloid_beta_deposits1.49570155
50MP0002735_abnormal_chemical_nociception1.49048355
51MP0005386_behavior/neurological_phenoty1.48106801
52MP0004924_abnormal_behavior1.48106801
53MP0004484_altered_response_of1.47257151
54MP0004145_abnormal_muscle_electrophysio1.46947552
55MP0002063_abnormal_learning/memory/cond1.43097464
56MP0002972_abnormal_cardiac_muscle1.40730642
57MP0002067_abnormal_sensory_capabilities1.39348697
58MP0001970_abnormal_pain_threshold1.38952937
59MP0005423_abnormal_somatic_nervous1.38945539
60MP0002638_abnormal_pupillary_reflex1.37346005
61MP0002733_abnormal_thermal_nociception1.32817779
62MP0005620_abnormal_muscle_contractility1.32688591
63MP0001485_abnormal_pinna_reflex1.31783043
64MP0004085_abnormal_heartbeat1.31441092
65MP0004859_abnormal_synaptic_plasticity1.30518907
66MP0001501_abnormal_sleep_pattern1.29617873
67MP0002332_abnormal_exercise_endurance1.24004357
68MP0005670_abnormal_white_adipose1.23480119
69MP0005408_hypopigmentation1.22690107
70MP0004742_abnormal_vestibular_system1.21867114
71MP0008932_abnormal_embryonic_tissue1.21574534
72MP0005379_endocrine/exocrine_gland_phen1.19539974
73MP0001727_abnormal_embryo_implantation1.19351560
74MP0010386_abnormal_urinary_bladder1.16399149
75MP0000778_abnormal_nervous_system1.15187032
76MP0002163_abnormal_gland_morphology1.14624750
77MP0005394_taste/olfaction_phenotype1.14434974
78MP0005499_abnormal_olfactory_system1.14434974
79MP0003136_yellow_coat_color1.14370162
80MP0005535_abnormal_body_temperature1.13666402
81MP0002184_abnormal_innervation1.12134510
82MP0008872_abnormal_physiological_respon1.11948564
83MP0000920_abnormal_myelination1.11850638
84MP0000013_abnormal_adipose_tissue1.10296779
85MP0003315_abnormal_perineum_morphology1.09210447
86MP0006072_abnormal_retinal_apoptosis1.06950352
87MP0002106_abnormal_muscle_physiology1.06309870
88MP0000750_abnormal_muscle_regeneration1.05615915
89MP0002095_abnormal_skin_pigmentation1.05540169
90MP0008775_abnormal_heart_ventricle1.05527293
91MP0003806_abnormal_nucleotide_metabolis1.03905291
92MP0001984_abnormal_olfaction1.03222243
93MP0001346_abnormal_lacrimal_gland1.02893082
94MP0001764_abnormal_homeostasis1.02616277
95MP0001293_anophthalmia1.02150188
96MP0008004_abnormal_stomach_pH1.02075684
97MP0003938_abnormal_ear_development1.01977843
98MP0000747_muscle_weakness0.99258370
99MP0005551_abnormal_eye_electrophysiolog0.98160529
100MP0000631_abnormal_neuroendocrine_gland0.98069500
101MP0004019_abnormal_vitamin_homeostasis0.97067521
102MP0002557_abnormal_social/conspecific_i0.96811566
103MP0005451_abnormal_body_composition0.96566846
104MP0002066_abnormal_motor_capabilities/c0.96094620
105MP0005365_abnormal_bile_salt0.94605989
106MP0005646_abnormal_pituitary_gland0.93131994
107MP0003077_abnormal_cell_cycle0.92550735
108MP0002132_abnormal_respiratory_system0.92350205
109MP0003878_abnormal_ear_physiology0.91672224
110MP0005377_hearing/vestibular/ear_phenot0.91672224
111MP0005085_abnormal_gallbladder_physiolo0.91600465
112MP0005369_muscle_phenotype0.90326336
113MP0001664_abnormal_digestion0.89942679
114MP0000230_abnormal_systemic_arterial0.89242782
115MP0002160_abnormal_reproductive_system0.89211460
116MP0006138_congestive_heart_failure0.89134533
117MP0005385_cardiovascular_system_phenoty0.88981799
118MP0001544_abnormal_cardiovascular_syste0.88981799
119MP0005409_darkened_coat_color0.88817588
120MP0002139_abnormal_hepatobiliary_system0.88763699
121MP0005636_abnormal_mineral_homeostasis0.88561793
122MP0002210_abnormal_sex_determination0.87997987
123MP0005645_abnormal_hypothalamus_physiol0.87678773
124MP0000462_abnormal_digestive_system0.86850647
125MP0010094_abnormal_chromosome_stability0.86475103
126MP0005332_abnormal_amino_acid0.84567695
127MP0004087_abnormal_muscle_fiber0.84091720
128MP0002229_neurodegeneration0.83832948
129MP0001188_hyperpigmentation0.82403657
130MP0008875_abnormal_xenobiotic_pharmacok0.82332374
131MP0005171_absent_coat_pigmentation0.81675174
132MP0003195_calcinosis0.80696552
133MP0000026_abnormal_inner_ear0.80385838
134MP0002876_abnormal_thyroid_physiology0.80174826
135MP0004130_abnormal_muscle_cell0.80103966
136MP0003011_delayed_dark_adaptation0.79923566
137MP0000358_abnormal_cell_content/0.79471539
138MP0004147_increased_porphyrin_level0.79425359
139MP0000538_abnormal_urinary_bladder0.79340816
140MP0005083_abnormal_biliary_tract0.79201239
141MP0002752_abnormal_somatic_nervous0.77728860
142MP0001963_abnormal_hearing_physiology0.77138155
143MP0002882_abnormal_neuron_morphology0.76879448
144MP0003111_abnormal_nucleus_morphology0.75931385
145MP0000343_altered_response_to0.75540770
146MP0005266_abnormal_metabolism0.74174394
147MP0008007_abnormal_cellular_replicative0.72624652
148MP0004133_heterotaxia0.72358637
149MP0009697_abnormal_copulation0.71389189
150MP0003121_genomic_imprinting0.71006873
151MP0005253_abnormal_eye_physiology0.70377316
152MP0002234_abnormal_pharynx_morphology0.69193660
153MP0005410_abnormal_fertilization0.67676952
154MP0009333_abnormal_splenocyte_physiolog0.67066390
155MP0003638_abnormal_response/metabolism_0.66630035
156MP0000049_abnormal_middle_ear0.65735574
157MP0009643_abnormal_urine_homeostasis0.63450971

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.97222388
2Abnormal mitochondria in muscle tissue (HP:0008316)7.31527767
3Progressive macrocephaly (HP:0004481)6.84937410
4Acute encephalopathy (HP:0006846)6.79089857
5* Mitochondrial inheritance (HP:0001427)6.65538580
6Hepatocellular necrosis (HP:0001404)6.05179350
7* Increased CSF lactate (HP:0002490)5.65915120
8Hepatic necrosis (HP:0002605)5.48408778
9Cerebral edema (HP:0002181)5.03604336
10Increased serum pyruvate (HP:0003542)4.34546244
11Abnormality of glycolysis (HP:0004366)4.34546244
12Respiratory failure (HP:0002878)4.28480906
13Optic disc pallor (HP:0000543)4.09772767
14Leukodystrophy (HP:0002415)3.96032477
15* Lactic acidosis (HP:0003128)3.92628512
16* Exercise intolerance (HP:0003546)3.86242906
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.80475572
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.80475572
19* Increased hepatocellular lipid droplets (HP:0006565)3.70947560
20* Lipid accumulation in hepatocytes (HP:0006561)3.50077018
213-Methylglutaconic aciduria (HP:0003535)3.46903292
22* Increased intramyocellular lipid droplets (HP:0012240)3.36256422
23* Increased serum lactate (HP:0002151)3.35282686
24Abnormality of cells of the erythroid lineage (HP:0012130)3.28209096
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20700431
26Sudden death (HP:0001699)3.19514497
27* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.18216180
28* Renal Fanconi syndrome (HP:0001994)3.14006044
29Muscle hypertrophy of the lower extremities (HP:0008968)3.11368380
30* Increased muscle lipid content (HP:0009058)3.10205907
31Aplastic anemia (HP:0001915)3.04556080
32Calf muscle hypertrophy (HP:0008981)2.92228277
33* Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.87498934
34Abnormal number of erythroid precursors (HP:0012131)2.86732439
35X-linked dominant inheritance (HP:0001423)2.84257962
36Pheochromocytoma (HP:0002666)2.78678586
37CNS demyelination (HP:0007305)2.78502356
38Neuroendocrine neoplasm (HP:0100634)2.77683741
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.74479247
40Lethargy (HP:0001254)2.73383593
41Generalized aminoaciduria (HP:0002909)2.69912961
42Parakeratosis (HP:0001036)2.69282841
43Oral leukoplakia (HP:0002745)2.68086131
44Emotional lability (HP:0000712)2.61494019
45Macrocytic anemia (HP:0001972)2.57260279
46Congenital, generalized hypertrichosis (HP:0004540)2.57009497
47Conjunctival hamartoma (HP:0100780)2.43679827
48Myokymia (HP:0002411)2.42043188
49Palpitations (HP:0001962)2.37288059
50Type I transferrin isoform profile (HP:0003642)2.37090363
51Focal motor seizures (HP:0011153)2.26896614
52Abnormality of placental membranes (HP:0011409)2.26222440
53Amniotic constriction ring (HP:0009775)2.26222440
54Cerebral hemorrhage (HP:0001342)2.18711342
55Absent thumb (HP:0009777)2.14644985
56Vomiting (HP:0002013)2.14509558
57Abnormal hemoglobin (HP:0011902)2.13367678
58Syncope (HP:0001279)2.09774334
59Pancytopenia (HP:0001876)2.04262013
60Abnormal pupillary function (HP:0007686)2.03080182
61Exercise-induced myalgia (HP:0003738)2.01853849
62* Glycosuria (HP:0003076)2.00858634
63* Abnormality of urine glucose concentration (HP:0011016)2.00858634
64Sensory axonal neuropathy (HP:0003390)2.00213332
65Reticulocytopenia (HP:0001896)2.00158226
66Abnormality of the calf musculature (HP:0001430)1.99789151
67* Abnormality of renal resorption (HP:0011038)1.99260829
68Dicarboxylic aciduria (HP:0003215)1.98575517
69Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98575517
70Congenital ichthyosiform erythroderma (HP:0007431)1.97240284
71Colon cancer (HP:0003003)1.96940104
72Prolonged QT interval (HP:0001657)1.96654786
73Ventricular fibrillation (HP:0001663)1.96424557
74Gliosis (HP:0002171)1.95346592
75Nausea (HP:0002018)1.94411629
76Abnormality of the anterior horn cell (HP:0006802)1.93592542
77Degeneration of anterior horn cells (HP:0002398)1.93592542
78Abnormality of alanine metabolism (HP:0010916)1.93562179
79Hyperalaninemia (HP:0003348)1.93562179
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93562179
81Myotonia (HP:0002486)1.92605736
82Abnormality of reticulocytes (HP:0004312)1.92241844
83Septo-optic dysplasia (HP:0100842)1.90212161
84Methylmalonic aciduria (HP:0012120)1.88835888
85Ventricular tachycardia (HP:0004756)1.87219599
86Myoglobinuria (HP:0002913)1.86602355
87Partial duplication of thumb phalanx (HP:0009944)1.85898174
88* Hyperphosphaturia (HP:0003109)1.85371062
89Pallor (HP:0000980)1.84994737
90Ketoacidosis (HP:0001993)1.84353638
91* Exertional dyspnea (HP:0002875)1.83496874
92Hyperglycinemia (HP:0002154)1.82881939
93Ragged-red muscle fibers (HP:0003200)1.81723961
94Muscle fiber splitting (HP:0003555)1.81111713
95Blindness (HP:0000618)1.80426132
96Muscle stiffness (HP:0003552)1.80330165
97Partial duplication of the phalanx of hand (HP:0009999)1.80267501
98* Respiratory difficulties (HP:0002880)1.80118641
99Pancreatic fibrosis (HP:0100732)1.79975721
100Atonic seizures (HP:0010819)1.79363540
101Methylmalonic acidemia (HP:0002912)1.79011625
102Hyperventilation (HP:0002883)1.76025386
103Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75549451
104Abnormality of midbrain morphology (HP:0002418)1.73823108
105Molar tooth sign on MRI (HP:0002419)1.73823108
106Rib fusion (HP:0000902)1.73383418
107Hypoplastic left heart (HP:0004383)1.72058776
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71368847
109Abnormal protein N-linked glycosylation (HP:0012347)1.71368847
110Abnormal protein glycosylation (HP:0012346)1.71368847
111Abnormal glycosylation (HP:0012345)1.71368847
112Delusions (HP:0000746)1.71130796
113Rhabdomyolysis (HP:0003201)1.71029309
114Retinal dysplasia (HP:0007973)1.70535844
115Limb dystonia (HP:0002451)1.69586018
116Anxiety (HP:0000739)1.69556639
117Microvesicular hepatic steatosis (HP:0001414)1.68494701
118Progressive external ophthalmoplegia (HP:0000590)1.68390544
119Neurofibrillary tangles (HP:0002185)1.66640529
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65631493
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.65631493
122Rimmed vacuoles (HP:0003805)1.64510263
123Exercise-induced muscle cramps (HP:0003710)1.62479818
124Sclerocornea (HP:0000647)1.61904059
125Depressed nasal ridge (HP:0000457)1.61706376
126Sparse eyelashes (HP:0000653)1.61339748
127Lipoatrophy (HP:0100578)1.60653096
128Supraventricular tachycardia (HP:0004755)1.60374707
129Pancreatic cysts (HP:0001737)1.59973793
130Abnormality of fatty-acid metabolism (HP:0004359)1.59521457
131Atrial fibrillation (HP:0005110)1.59353006
132Rough bone trabeculation (HP:0100670)1.59313316
133True hermaphroditism (HP:0010459)1.59195360
134Muscle fiber atrophy (HP:0100295)1.59008734
135Reduced antithrombin III activity (HP:0001976)1.58969742
136Testicular atrophy (HP:0000029)1.58501018
137Concave nail (HP:0001598)1.57610297
138Cleft eyelid (HP:0000625)1.55192239
139Absent septum pellucidum (HP:0001331)1.54147905
140Type 2 muscle fiber atrophy (HP:0003554)1.50285855
141Metabolic acidosis (HP:0001942)1.50281611
142Abnormality of serum amino acid levels (HP:0003112)1.49911662
143Triphalangeal thumb (HP:0001199)1.43629262
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.43574538
145Maternal diabetes (HP:0009800)1.42945186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.85674532
2NME13.81036662
3STK393.43169853
4MAP3K123.29684749
5MYLK2.85951371
6TESK22.70569469
7OXSR12.59999344
8WNK42.59447950
9ZAK2.47098427
10NME22.45278857
11PNCK2.28182103
12CCNB12.10801984
13CDC72.09737718
14PBK2.09311884
15OBSCN2.07586261
16STK162.03411726
17GRK72.02966184
18CDK192.02596788
19ARAF2.01029293
20CASK1.97908963
21LMTK21.97160109
22MST41.95214853
23TESK11.78186691
24TNIK1.71734867
25MUSK1.70787097
26EPHA41.70145092
27PHKG21.67065500
28PHKG11.67065500
29TAF11.61522467
30MAP2K71.61196293
31GRK51.58947197
32TLK11.58871399
33MARK11.56762663
34LRRK21.54554065
35BCKDK1.48819705
36MAP3K41.46298998
37SRPK11.45398914
38LIMK11.44922560
39NUAK11.40531435
40BCR1.39144424
41WNK31.34611263
42NEK11.28972936
43FGR1.24084346
44CAMK2D1.23716925
45NTRK31.23107302
46PDK31.21955746
47PDK41.21955746
48CAMK2A1.21536464
49CAMK2B1.20723746
50NEK21.16104295
51UHMK11.15932950
52MAP2K41.12371641
53MAPK131.11550946
54MAPKAPK51.06232031
55PKN11.05869118
56RIPK41.01315133
57VRK11.01232833
58DAPK31.00707610
59ADRBK10.97756004
60DYRK20.97559233
61ABL20.96816674
62CAMK2G0.96103536
63MINK10.95865087
64ROCK20.95803173
65ADRBK20.92374102
66BMPR1B0.92204159
67DYRK30.89646190
68PLK20.87877479
69CDK80.87123135
70PAK30.86940376
71AURKB0.86755541
72PRKCE0.84080769
73PTK2B0.82452335
74PIK3CA0.80963325
75CSNK2A20.80782103
76RPS6KA50.79562668
77ILK0.79490458
78PLK30.78877993
79MAP4K20.76562003
80EIF2AK10.76247994
81CSNK1G30.75854196
82PDK20.75800392
83NTRK20.74658436
84DAPK10.73566830
85PRKACA0.71807442
86BRAF0.68984999
87GRK60.67531392
88WEE10.67435208
89CSNK2A10.67319931
90BMPR20.66705309
91CHEK20.65949196
92PLK10.65275889
93CDK50.64773880
94MAP3K110.63454495
95BRSK10.63214298
96BUB10.62927362
97TXK0.62124855
98PIM20.61620774
99NTRK10.60059872
100PINK10.59772048
101PRKCG0.59174483
102STK40.59118831
103FES0.58902868
104MAPK120.57932799
105CDK140.56798063
106TTK0.55963968
107GRK10.55563707
108PLK40.55492885
109PIK3CG0.54876710
110MST1R0.53263506
111PASK0.51110221
112TIE10.51087228
113KDR0.50544435
114TTN0.50121735
115MAP3K90.50064894
116PAK10.49934390
117CAMKK20.48194745
118ROCK10.47330637
119EPHB20.45452959
120RPS6KB20.45114322
121PRKCI0.44686270
122CDK11A0.43606532
123CDK150.43310503
124ATR0.43119770
125MAPK40.43099071
126CSNK1G20.42854186
127MAPK150.42320760
128CDK180.41596242
129INSRR0.39053389
130CAMK10.37801941
131ERBB40.37693921
132PAK40.37689600
133PRKCQ0.36704471
134CSNK1E0.36625750
135PRKCA0.36554991
136PRKG10.35770281
137DAPK20.34802769
138MAP2K60.34559780
139AURKA0.34036288
140CSNK1G10.33621230
141WNK10.32764567
142MAPKAPK30.31274660
143CSNK1A1L0.30246911
144BRSK20.30237296
145CSNK1A10.30049483
146PRKCD0.29208691
147IKBKB0.26414924

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.81364935
2Parkinsons disease_Homo sapiens_hsa050125.78384539
3Alzheimers disease_Homo sapiens_hsa050104.53615375
4Huntingtons disease_Homo sapiens_hsa050163.98850212
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.69553696
6Ribosome_Homo sapiens_hsa030103.56237454
7* Cardiac muscle contraction_Homo sapiens_hsa042603.43353582
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.45013477
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41466904
10Proteasome_Homo sapiens_hsa030502.28199213
11DNA replication_Homo sapiens_hsa030302.00509204
12Fatty acid elongation_Homo sapiens_hsa000621.97001762
13Mismatch repair_Homo sapiens_hsa034301.96708854
14Collecting duct acid secretion_Homo sapiens_hsa049661.85289513
15Homologous recombination_Homo sapiens_hsa034401.76434880
16Protein export_Homo sapiens_hsa030601.69247653
17Propanoate metabolism_Homo sapiens_hsa006401.65092443
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55186563
19Pyruvate metabolism_Homo sapiens_hsa006201.48390207
20Butanoate metabolism_Homo sapiens_hsa006501.48108754
21Sulfur metabolism_Homo sapiens_hsa009201.40725726
22Spliceosome_Homo sapiens_hsa030401.40569832
23Nicotine addiction_Homo sapiens_hsa050331.38799550
24Base excision repair_Homo sapiens_hsa034101.37797723
25RNA polymerase_Homo sapiens_hsa030201.35615505
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34396352
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34391737
28Nucleotide excision repair_Homo sapiens_hsa034201.30818940
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30146802
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16756075
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13509223
32Vibrio cholerae infection_Homo sapiens_hsa051101.12976545
33Carbon metabolism_Homo sapiens_hsa012001.01476054
34One carbon pool by folate_Homo sapiens_hsa006700.97535996
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94950942
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90794740
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89339413
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87173647
39Synaptic vesicle cycle_Homo sapiens_hsa047210.86293339
40Basal transcription factors_Homo sapiens_hsa030220.84761007
41Fatty acid degradation_Homo sapiens_hsa000710.84169656
42* Metabolic pathways_Homo sapiens_hsa011000.83844472
43Fanconi anemia pathway_Homo sapiens_hsa034600.82369858
44Fatty acid metabolism_Homo sapiens_hsa012120.81883112
45RNA degradation_Homo sapiens_hsa030180.81611560
46Serotonergic synapse_Homo sapiens_hsa047260.81227527
47GABAergic synapse_Homo sapiens_hsa047270.79055918
48Tyrosine metabolism_Homo sapiens_hsa003500.76785068
49Phenylalanine metabolism_Homo sapiens_hsa003600.75076178
50RNA transport_Homo sapiens_hsa030130.69945192
51Systemic lupus erythematosus_Homo sapiens_hsa053220.69789570
52Glutathione metabolism_Homo sapiens_hsa004800.66717032
53Taste transduction_Homo sapiens_hsa047420.65767856
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63068865
55Peroxisome_Homo sapiens_hsa041460.61077819
56Steroid biosynthesis_Homo sapiens_hsa001000.60495892
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59233455
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58501939
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58493002
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57632193
61Arginine and proline metabolism_Homo sapiens_hsa003300.55841839
62Morphine addiction_Homo sapiens_hsa050320.54284157
63Dilated cardiomyopathy_Homo sapiens_hsa054140.53931477
64Glutamatergic synapse_Homo sapiens_hsa047240.53265698
65Ether lipid metabolism_Homo sapiens_hsa005650.52665963
66Nitrogen metabolism_Homo sapiens_hsa009100.51654798
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49802345
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.49358623
69Renin secretion_Homo sapiens_hsa049240.48815119
70Calcium signaling pathway_Homo sapiens_hsa040200.48259141
71Histidine metabolism_Homo sapiens_hsa003400.47256105
72Pyrimidine metabolism_Homo sapiens_hsa002400.46789587
73beta-Alanine metabolism_Homo sapiens_hsa004100.46409943
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45476965
75Gastric acid secretion_Homo sapiens_hsa049710.45377197
76Rheumatoid arthritis_Homo sapiens_hsa053230.45286836
77Amphetamine addiction_Homo sapiens_hsa050310.45236826
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44325564
79Phototransduction_Homo sapiens_hsa047440.43550404
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43526372
81Circadian entrainment_Homo sapiens_hsa047130.43347995
82Salivary secretion_Homo sapiens_hsa049700.43236665
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43113444
84Dopaminergic synapse_Homo sapiens_hsa047280.42745747
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42669081
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.42143321
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41531544
88Vitamin digestion and absorption_Homo sapiens_hsa049770.39390718
89Linoleic acid metabolism_Homo sapiens_hsa005910.38925969
90Long-term depression_Homo sapiens_hsa047300.37976758
91Arachidonic acid metabolism_Homo sapiens_hsa005900.37719637
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.36759514
93Mineral absorption_Homo sapiens_hsa049780.35903039
94Tryptophan metabolism_Homo sapiens_hsa003800.32689721
95Chemical carcinogenesis_Homo sapiens_hsa052040.32577797
96Long-term potentiation_Homo sapiens_hsa047200.32200314
97Galactose metabolism_Homo sapiens_hsa000520.32014943
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31593811
99Caffeine metabolism_Homo sapiens_hsa002320.31328152
100Alcoholism_Homo sapiens_hsa050340.30726163
101Cholinergic synapse_Homo sapiens_hsa047250.30155824
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29857210
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29568232
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.29351215
105PPAR signaling pathway_Homo sapiens_hsa033200.28428550
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28344191
107Sulfur relay system_Homo sapiens_hsa041220.28315731
108Purine metabolism_Homo sapiens_hsa002300.28184055
109Pentose phosphate pathway_Homo sapiens_hsa000300.26489512
110Retinol metabolism_Homo sapiens_hsa008300.26164430
111Fat digestion and absorption_Homo sapiens_hsa049750.25865315
112Oxytocin signaling pathway_Homo sapiens_hsa049210.25830967
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.25762333
114Cocaine addiction_Homo sapiens_hsa050300.25584928
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.25569967
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25403154
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.24067721
118Arginine biosynthesis_Homo sapiens_hsa002200.23890581
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23246623
120Epstein-Barr virus infection_Homo sapiens_hsa051690.22208738
121Asthma_Homo sapiens_hsa053100.21867509
122Pancreatic secretion_Homo sapiens_hsa049720.21270644
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20274783
124Axon guidance_Homo sapiens_hsa043600.20101727
125Folate biosynthesis_Homo sapiens_hsa007900.18860556
126Regulation of autophagy_Homo sapiens_hsa041400.18819634
127Biosynthesis of amino acids_Homo sapiens_hsa012300.17644079
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17413930
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16930648
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16612270
131Insulin secretion_Homo sapiens_hsa049110.16487460
132Cell cycle_Homo sapiens_hsa041100.16102105
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15957550
134Olfactory transduction_Homo sapiens_hsa047400.15780095
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15558349
136Gap junction_Homo sapiens_hsa045400.15202865
137N-Glycan biosynthesis_Homo sapiens_hsa005100.14714595
138Phagosome_Homo sapiens_hsa041450.13763939
139Sphingolipid metabolism_Homo sapiens_hsa006000.13576312
140Fructose and mannose metabolism_Homo sapiens_hsa000510.12874936

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »