COX6B1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.41971487
2interferon-gamma production (GO:0032609)5.37530629
3positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.56660100
4regulation of chronic inflammatory response (GO:0002676)4.16607232
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13590928
6positive regulation of humoral immune response (GO:0002922)4.06797572
7regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.99924818
8pseudouridine synthesis (GO:0001522)3.91188263
9lymph node development (GO:0048535)3.74271193
10positive regulation of T cell mediated cytotoxicity (GO:0001916)3.68072947
11GTP biosynthetic process (GO:0006183)3.67843121
12cellular response to interleukin-15 (GO:0071350)3.66224314
13regulation of T cell mediated cytotoxicity (GO:0001914)3.64186200
14tryptophan metabolic process (GO:0006568)3.61069739
15T-helper cell differentiation (GO:0042093)3.59429370
16CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.59429370
17positive regulation of T cell differentiation in thymus (GO:0033089)3.56970891
18cullin deneddylation (GO:0010388)3.55222790
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.49757169
20cytidine deamination (GO:0009972)3.48898695
21cytidine metabolic process (GO:0046087)3.48898695
22cytidine catabolic process (GO:0006216)3.48898695
23positive regulation of granulocyte differentiation (GO:0030854)3.46157639
24alpha-beta T cell differentiation (GO:0046632)3.42997139
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35108018
26regulation of inflammatory response to antigenic stimulus (GO:0002861)3.30215728
27protein deneddylation (GO:0000338)3.28271216
28regulation of gamma-delta T cell differentiation (GO:0045586)3.27618249
29termination of RNA polymerase III transcription (GO:0006386)3.26164967
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.26164967
31UTP biosynthetic process (GO:0006228)3.24744921
32alpha-beta T cell differentiation involved in immune response (GO:0002293)3.23025868
33alpha-beta T cell activation involved in immune response (GO:0002287)3.23025868
34T cell differentiation involved in immune response (GO:0002292)3.23025868
35tryptophan catabolic process (GO:0006569)3.22578773
36indole-containing compound catabolic process (GO:0042436)3.22578773
37indolalkylamine catabolic process (GO:0046218)3.22578773
38inner mitochondrial membrane organization (GO:0007007)3.20905024
39aldehyde catabolic process (GO:0046185)3.17965014
40exogenous drug catabolic process (GO:0042738)3.17275939
41indolalkylamine metabolic process (GO:0006586)3.16969242
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.14706329
43alpha-beta T cell activation (GO:0046631)3.14503869
44positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.12374305
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.12117218
46regulation of regulatory T cell differentiation (GO:0045589)3.10310223
47regulation of cellular amino acid metabolic process (GO:0006521)3.08243882
48positive regulation of defense response to virus by host (GO:0002230)3.07781300
49regulation of oxidative phosphorylation (GO:0002082)3.06944814
50kynurenine metabolic process (GO:0070189)3.05796357
51regulation of T cell receptor signaling pathway (GO:0050856)3.03213931
52microtubule severing (GO:0051013)3.02488794
53auditory receptor cell stereocilium organization (GO:0060088)2.99840192
54cellular ketone body metabolic process (GO:0046950)2.98761726
55UTP metabolic process (GO:0046051)2.98036135
56protein complex biogenesis (GO:0070271)2.97013192
57Peyers patch development (GO:0048541)2.96821929
58mucosal-associated lymphoid tissue development (GO:0048537)2.96821929
59mast cell activation (GO:0045576)2.92768547
60pyrimidine ribonucleoside catabolic process (GO:0046133)2.91851767
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89998454
62ATP synthesis coupled proton transport (GO:0015986)2.89924201
63energy coupled proton transport, down electrochemical gradient (GO:0015985)2.89924201
64positive regulation of B cell mediated immunity (GO:0002714)2.89226611
65positive regulation of immunoglobulin mediated immune response (GO:0002891)2.89226611
66water-soluble vitamin biosynthetic process (GO:0042364)2.87016934
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86969238
68ribosome assembly (GO:0042255)2.86847326
69drug catabolic process (GO:0042737)2.86228802
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85795315
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85795315
72glyoxylate metabolic process (GO:0046487)2.84807076
73electron transport chain (GO:0022900)2.81988714
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79971482
75regulation of gamma-delta T cell activation (GO:0046643)2.77267126
76respiratory electron transport chain (GO:0022904)2.76796057
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75167328
78mitochondrial respiratory chain complex assembly (GO:0033108)2.73761831
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73562671
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69497361
81regulation of cell killing (GO:0031341)2.67957225
82regulation of B cell receptor signaling pathway (GO:0050855)2.67849106
83antigen processing and presentation via MHC class Ib (GO:0002475)2.65976250
84dopamine transport (GO:0015872)2.65755717
85rRNA modification (GO:0000154)2.64273546
86purine nucleotide salvage (GO:0032261)2.63025966
87respiratory chain complex IV assembly (GO:0008535)2.62853655
88ketone body metabolic process (GO:1902224)2.61156562
89positive regulation of cell killing (GO:0031343)2.60877979
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60731250
91response to interleukin-15 (GO:0070672)2.58560470
92CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.57770374
93inositol phosphate catabolic process (GO:0071545)2.57486821
94proteasome assembly (GO:0043248)2.57381829
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57222419
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.57222419
97NADH dehydrogenase complex assembly (GO:0010257)2.57222419
98neurotransmitter catabolic process (GO:0042135)2.55491167
99aromatic amino acid family catabolic process (GO:0009074)2.55341719
100cytochrome complex assembly (GO:0017004)2.54430774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04236123
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77000614
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.74995953
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.62497229
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.56220909
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51097504
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.31089214
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.05262560
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92930437
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.86831631
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86273708
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.70128892
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68329771
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62552639
15VDR_23849224_ChIP-Seq_CD4+_Human2.55136980
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53563205
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.52595022
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.36929001
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.33605383
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32423430
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19708766
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.11366721
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10382087
24FOXP3_21729870_ChIP-Seq_TREG_Human2.07476661
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.96184316
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.85305769
27GATA3_26560356_Chip-Seq_TH2_Human1.77694514
28TP53_22573176_ChIP-Seq_HFKS_Human1.75680505
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68828419
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65270462
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57575077
32GATA1_22025678_ChIP-Seq_K562_Human1.56548084
33MYB_26560356_Chip-Seq_TH2_Human1.56192752
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52859552
35VDR_22108803_ChIP-Seq_LS180_Human1.51148875
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47778748
37IGF1R_20145208_ChIP-Seq_DFB_Human1.39436491
38ZNF274_21170338_ChIP-Seq_K562_Hela1.38532308
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37845698
40AR_20517297_ChIP-Seq_VCAP_Human1.36943385
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33546127
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31622410
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31142040
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27324125
45NCOR_22424771_ChIP-Seq_293T_Human1.26589611
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.22732283
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22732283
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22483048
49GATA3_27048872_Chip-Seq_THYMUS_Human1.22247749
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16074515
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13454828
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13242597
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.13234862
54ER_23166858_ChIP-Seq_MCF-7_Human1.12761809
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12446098
56CBP_20019798_ChIP-Seq_JUKART_Human1.12446098
57ELK1_19687146_ChIP-ChIP_HELA_Human1.12367079
58FOXH1_21741376_ChIP-Seq_EPCs_Human1.10430272
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10051809
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09797070
61SOX2_19829295_ChIP-Seq_ESCs_Human1.08083914
62NANOG_19829295_ChIP-Seq_ESCs_Human1.08083914
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07838949
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07784500
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07484679
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.05712833
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05292398
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.05110929
69MYC_18940864_ChIP-ChIP_HL60_Human1.04237761
70DCP1A_22483619_ChIP-Seq_HELA_Human1.03599953
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03442230
72GABP_19822575_ChIP-Seq_HepG2_Human1.03350436
73ELF5_23300383_ChIP-Seq_T47D_Human1.03215273
74RUNX_20019798_ChIP-Seq_JUKART_Human1.03156429
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01486240
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00570680
77MYB_26560356_Chip-Seq_TH1_Human1.00516455
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99718061
79ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98972075
80HOXB7_26014856_ChIP-Seq_BT474_Human0.98251929
81SPI1_23547873_ChIP-Seq_NB4_Human0.98060295
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97820458
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96929672
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96876094
85STAT1_20625510_ChIP-Seq_HELA_Human0.95893113
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94706670
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92406421
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92297885
89MYC_19829295_ChIP-Seq_ESCs_Human0.91985606
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91720118
91BCAT_22108803_ChIP-Seq_LS180_Human0.91035744
92ERG_20517297_ChIP-Seq_VCAP_Human0.90877703
93P300_27268052_Chip-Seq_Bcells_Human0.90814614
94GATA3_26560356_Chip-Seq_TH1_Human0.89509249
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.88965664
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88923713
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88718652
98HTT_18923047_ChIP-ChIP_STHdh_Human0.88368479
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87634742
100NANOG_20526341_ChIP-Seq_ESCs_Human0.87589129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.59566949
2MP0002102_abnormal_ear_morphology3.21349221
3MP0003195_calcinosis3.19928731
4MP0005671_abnormal_response_to3.18116346
5MP0009785_altered_susceptibility_to2.98470393
6MP0000685_abnormal_immune_system2.85948358
7MP0003436_decreased_susceptibility_to2.83801174
8MP0003806_abnormal_nucleotide_metabolis2.83111739
9MP0005377_hearing/vestibular/ear_phenot2.62176465
10MP0003878_abnormal_ear_physiology2.62176465
11MP0001835_abnormal_antigen_presentation2.56424435
12MP0003763_abnormal_thymus_physiology2.37172621
13MP0008872_abnormal_physiological_respon2.26896331
14MP0001501_abnormal_sleep_pattern2.10149172
15MP0005000_abnormal_immune_tolerance2.06976219
16MP0002148_abnormal_hypersensitivity_rea2.06187837
17MP0008875_abnormal_xenobiotic_pharmacok2.04332283
18MP0004381_abnormal_hair_follicle1.99785558
19MP0002138_abnormal_hepatobiliary_system1.94752060
20MP0002837_dystrophic_cardiac_calcinosis1.94178306
21MP0009333_abnormal_splenocyte_physiolog1.82687954
22MP0001800_abnormal_humoral_immune1.82376764
23MP0005645_abnormal_hypothalamus_physiol1.78424169
24MP0005085_abnormal_gallbladder_physiolo1.69201984
25MP0008877_abnormal_DNA_methylation1.69180811
26MP0003252_abnormal_bile_duct1.68448188
27MP0002139_abnormal_hepatobiliary_system1.68342397
28MP0005075_abnormal_melanosome_morpholog1.66877545
29MP0003866_abnormal_defecation1.66430474
30MP0006072_abnormal_retinal_apoptosis1.60847795
31MP0004147_increased_porphyrin_level1.59794324
32MP0003646_muscle_fatigue1.57804372
33MP0002723_abnormal_immune_serum1.56424161
34MP0009764_decreased_sensitivity_to1.50036793
35MP0005025_abnormal_response_to1.47363932
36MP0005551_abnormal_eye_electrophysiolog1.47004270
37MP0001790_abnormal_immune_system1.45559170
38MP0005387_immune_system_phenotype1.45559170
39MP0002452_abnormal_antigen_presenting1.45497555
40MP0001819_abnormal_immune_cell1.44802108
41MP0002420_abnormal_adaptive_immunity1.44763977
42MP0010155_abnormal_intestine_physiology1.44220343
43MP0003786_premature_aging1.43641143
44MP0001845_abnormal_inflammatory_respons1.43091262
45MP0001873_stomach_inflammation1.40333281
46MP0005332_abnormal_amino_acid1.39572018
47MP0001533_abnormal_skeleton_physiology1.36974860
48MP0005084_abnormal_gallbladder_morpholo1.34713497
49MP0005646_abnormal_pituitary_gland1.34393445
50MP0006036_abnormal_mitochondrial_physio1.29246294
51MP0009780_abnormal_chondrocyte_physiolo1.28560926
52MP0008469_abnormal_protein_level1.23702309
53MP0001919_abnormal_reproductive_system1.23674248
54MP0005636_abnormal_mineral_homeostasis1.22077010
55MP0005423_abnormal_somatic_nervous1.20062353
56MP0008058_abnormal_DNA_repair1.19717430
57MP0002405_respiratory_system_inflammati1.18037495
58MP0002876_abnormal_thyroid_physiology1.15656380
59MP0005389_reproductive_system_phenotype1.15293749
60MP0003011_delayed_dark_adaptation1.13450591
61MP0005365_abnormal_bile_salt1.11711123
62MP0000689_abnormal_spleen_morphology1.10478798
63MP0002419_abnormal_innate_immunity1.10058572
64MP0003186_abnormal_redox_activity1.09308944
65MP0003172_abnormal_lysosome_physiology1.08565047
66MP0005410_abnormal_fertilization1.08253329
67MP0002398_abnormal_bone_marrow1.08230406
68MP0009643_abnormal_urine_homeostasis1.07615514
69MP0003724_increased_susceptibility_to1.06199931
70MP0009697_abnormal_copulation1.05646780
71MP0000716_abnormal_immune_system1.05613865
72MP0001764_abnormal_homeostasis1.05552776
73MP0004885_abnormal_endolymph1.04161517
74MP0005165_increased_susceptibility_to1.03912212
75MP0000703_abnormal_thymus_morphology1.03876509
76MP0002693_abnormal_pancreas_physiology1.01535297
77MP0005319_abnormal_enzyme/_coenzyme0.98700445
78MP0005310_abnormal_salivary_gland0.98085463
79MP0001666_abnormal_nutrient_absorption0.95266586
80MP0001765_abnormal_ion_homeostasis0.94651176
81MP0005253_abnormal_eye_physiology0.91190979
82MP0002272_abnormal_nervous_system0.90059151
83MP0000013_abnormal_adipose_tissue0.89698664
84MP0001968_abnormal_touch/_nociception0.88654207
85MP0002722_abnormal_immune_system0.85155643
86MP0000372_irregular_coat_pigmentation0.85147949
87MP0010386_abnormal_urinary_bladder0.83929466
88MP0002429_abnormal_blood_cell0.83320608
89MP0001485_abnormal_pinna_reflex0.76845337
90MP0010329_abnormal_lipoprotein_level0.76273309
91MP0009046_muscle_twitch0.76143057
92MP0000609_abnormal_liver_physiology0.74583084
93MP0000427_abnormal_hair_cycle0.73670537
94MP0001756_abnormal_urination0.72335013
95MP0005360_urolithiasis0.71505864
96MP0002006_tumorigenesis0.69833938
97MP0002136_abnormal_kidney_physiology0.67286481
98MP0010368_abnormal_lymphatic_system0.66439204
99MP0002160_abnormal_reproductive_system0.66420368
100MP0001944_abnormal_pancreas_morphology0.66259056

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.34072063
2Optic neuritis (HP:0100653)4.34072063
3Severe combined immunodeficiency (HP:0004430)3.77809042
4Elevated erythrocyte sedimentation rate (HP:0003565)3.76283954
5Mitochondrial inheritance (HP:0001427)3.72828128
6Aplastic anemia (HP:0001915)3.69998980
7Orchitis (HP:0100796)3.69592908
8Acute necrotizing encephalopathy (HP:0006965)3.66781111
9Myositis (HP:0100614)3.51862803
10Increased CSF lactate (HP:0002490)3.49428337
11Lipid accumulation in hepatocytes (HP:0006561)3.42963160
12Hepatic necrosis (HP:0002605)3.42559227
13Thyroiditis (HP:0100646)3.40436696
14Increased hepatocellular lipid droplets (HP:0006565)3.39922282
15Stomatitis (HP:0010280)3.37710161
16Hepatocellular necrosis (HP:0001404)3.33215019
17Acute encephalopathy (HP:0006846)3.25491725
18Abnormal mitochondria in muscle tissue (HP:0008316)3.21311302
19Progressive macrocephaly (HP:0004481)3.15959068
20Hypothermia (HP:0002045)3.01249205
21Keratoconjunctivitis sicca (HP:0001097)2.89126627
22Combined immunodeficiency (HP:0005387)2.87653710
23Keratoconjunctivitis (HP:0001096)2.85369230
24Anorexia (HP:0002039)2.85153868
25IgG deficiency (HP:0004315)2.84798154
26Abnormality of the renal cortex (HP:0011035)2.71617205
27Autoimmune thrombocytopenia (HP:0001973)2.69121530
28Renal Fanconi syndrome (HP:0001994)2.68739278
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65339081
30Cerebral edema (HP:0002181)2.64729652
31Autoimmune hemolytic anemia (HP:0001890)2.61142750
32Encephalitis (HP:0002383)2.60136093
33Increased intramyocellular lipid droplets (HP:0012240)2.59926179
34Congenital stationary night blindness (HP:0007642)2.57241141
35Abnormality of B cell number (HP:0010975)2.54914324
36Methylmalonic aciduria (HP:0012120)2.48221899
37Increased serum lactate (HP:0002151)2.47492176
38Congenital, generalized hypertrichosis (HP:0004540)2.47224399
39Methylmalonic acidemia (HP:0002912)2.45864209
40Gastrointestinal infarctions (HP:0005244)2.42027056
41Gangrene (HP:0100758)2.41927759
423-Methylglutaconic aciduria (HP:0003535)2.41910531
43Abnormality of T cell physiology (HP:0011840)2.38154510
44Hypoproteinemia (HP:0003075)2.38107420
45Increased muscle lipid content (HP:0009058)2.36681498
46Glycosuria (HP:0003076)2.36502047
47Abnormality of urine glucose concentration (HP:0011016)2.36502047
48Abnormality of T cells (HP:0002843)2.35632578
49Pancreatic cysts (HP:0001737)2.35458170
50Aplasia/hypoplasia of the uterus (HP:0008684)2.31110814
51Polydipsia (HP:0001959)2.30212355
52Abnormal drinking behavior (HP:0030082)2.30212355
53Abnormality of methionine metabolism (HP:0010901)2.29029911
54Abnormality of T cell number (HP:0011839)2.28505771
55Abnormality of alanine metabolism (HP:0010916)2.28439555
56Hyperalaninemia (HP:0003348)2.28439555
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28439555
58Mesangial abnormality (HP:0001966)2.25826524
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24010035
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23798929
61Pigmentary retinal degeneration (HP:0001146)2.22025994
62Abnormality of eosinophils (HP:0001879)2.22000219
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21441386
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21441386
65Renal cortical cysts (HP:0000803)2.20649556
66Lactic acidosis (HP:0003128)2.19964908
67Chronic diarrhea (HP:0002028)2.17768598
68T lymphocytopenia (HP:0005403)2.16845103
69Type 2 muscle fiber atrophy (HP:0003554)2.14411288
70Chronic hepatic failure (HP:0100626)2.13959839
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13569340
72Dicarboxylic aciduria (HP:0003215)2.13569340
73Ketosis (HP:0001946)2.13306819
74Hemoptysis (HP:0002105)2.10425484
75Abnormality of the prostate (HP:0008775)2.09293127
76Cerebral hypomyelination (HP:0006808)2.06774108
77Hypomagnesemia (HP:0002917)2.06556319
78Abnormality of vitamin B metabolism (HP:0004340)2.04037501
79Lethargy (HP:0001254)2.04030387
80Pancreatitis (HP:0001733)2.02063880
81Generalized aminoaciduria (HP:0002909)1.98987190
82Recurrent bronchitis (HP:0002837)1.95814846
83B lymphocytopenia (HP:0010976)1.95471436
84Pulmonary infiltrates (HP:0002113)1.94830273
85Chronic otitis media (HP:0000389)1.94408875
86Hyperphosphaturia (HP:0003109)1.93672853
87Oral leukoplakia (HP:0002745)1.93012995
88Vasculitis (HP:0002633)1.91493051
89Abnormality of the vitamin B12 metabolism (HP:0004341)1.89799596
90Respiratory failure (HP:0002878)1.88756406
91Muscle fiber atrophy (HP:0100295)1.86748033
92Testicular atrophy (HP:0000029)1.86539664
93Pancytopenia (HP:0001876)1.86077189
94Stomach cancer (HP:0012126)1.84797707
95Exertional dyspnea (HP:0002875)1.83262952
96Hypoplasia of the uterus (HP:0000013)1.82228925
97Polyuria (HP:0000103)1.80321845
98Keratitis (HP:0000491)1.79658264
99Tubular atrophy (HP:0000092)1.77918146
100Abnormality of endocrine pancreas physiology (HP:0012093)1.77342134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.04549177
2MAP4K23.52699426
3TAOK33.42748038
4TLK12.99116387
5MST42.69812301
6STK392.46466554
7EIF2AK32.22482582
8ADRBK22.16083532
9MAP3K142.13382334
10WNK42.04412909
11VRK21.92137993
12MAP3K121.86591378
13FRK1.85149731
14PASK1.83888016
15MAP2K61.78397256
16ZAK1.75905700
17MAP4K11.70190119
18NUAK11.67405471
19SIK21.64516418
20IKBKE1.63492963
21SRPK11.62421915
22NLK1.58406578
23GRK11.58117986
24TEC1.52517284
25TSSK61.45262520
26OXSR11.44047725
27ITK1.41083173
28IKBKB1.37562746
29GRK61.33357203
30SIK31.29713908
31MAPKAPK31.29106831
32PINK11.24855087
33NEK11.18847181
34STK161.18435933
35SCYL21.13332228
36EPHA31.06507163
37PHKG21.03523973
38PHKG11.03523973
39INSRR0.99304518
40BCKDK0.98007519
41DAPK10.97828567
42TNK20.91317333
43CHUK0.86952303
44CDK80.86733899
45BMPR20.86108624
46SYK0.83641135
47TYK20.83414990
48PIK3CG0.82714143
49ALK0.79425366
50JAK30.75224200
51BTK0.73535445
52TESK20.71302180
53KIT0.69572606
54VRK10.67784414
55CAMKK20.66978012
56LYN0.66973751
57TBK10.62168137
58NME10.62078620
59IRAK40.61771501
60LCK0.60542326
61KDR0.58724250
62FER0.55090554
63RIPK40.54537343
64FES0.51049618
65BUB10.50379732
66MAP3K130.49509746
67PRKCQ0.48522908
68CLK10.47443708
69CAMKK10.46045211
70RPS6KA50.45859649
71TESK10.45724686
72MYLK0.45351915
73MAP3K110.44260498
74FGFR40.43823215
75EIF2AK20.42499539
76PAK30.42234166
77IGF1R0.42062986
78FGFR30.41954841
79MAPKAPK50.40811908
80MARK30.38741378
81JAK10.37297879
82MAP2K20.34596820
83RPS6KB20.34463825
84TRPM70.34360572
85ILK0.31394313
86IRAK10.28995578
87WNK30.26812436
88IRAK30.26529958
89TAF10.26107230
90ZAP700.25723217
91DAPK20.24468987
92MAPK130.23465820
93HCK0.22752807
94MAPK110.22547505
95ABL10.21963734
96PRKCA0.21424952
97OBSCN0.19976755
98MKNK10.19705953
99MAP3K40.19092998
100MKNK20.18362354

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.08031632
2RNA polymerase_Homo sapiens_hsa030203.51442059
3Protein export_Homo sapiens_hsa030603.26462770
4Oxidative phosphorylation_Homo sapiens_hsa001903.12519909
5Primary immunodeficiency_Homo sapiens_hsa053402.78368067
6One carbon pool by folate_Homo sapiens_hsa006702.74468684
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36179789
8Parkinsons disease_Homo sapiens_hsa050122.32734663
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09171365
10Sulfur metabolism_Homo sapiens_hsa009202.04393788
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99990409
12Linoleic acid metabolism_Homo sapiens_hsa005911.98358591
13Type I diabetes mellitus_Homo sapiens_hsa049401.89826225
14Nitrogen metabolism_Homo sapiens_hsa009101.74213651
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69796796
16Caffeine metabolism_Homo sapiens_hsa002321.67297476
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.65481093
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63069908
19RNA degradation_Homo sapiens_hsa030181.61767740
20Ribosome_Homo sapiens_hsa030101.56621210
21Pyrimidine metabolism_Homo sapiens_hsa002401.54752908
22Phototransduction_Homo sapiens_hsa047441.50697379
23Alzheimers disease_Homo sapiens_hsa050101.49833944
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.42098455
25Tryptophan metabolism_Homo sapiens_hsa003801.40921708
26Asthma_Homo sapiens_hsa053101.38708283
27Butanoate metabolism_Homo sapiens_hsa006501.37081205
28Allograft rejection_Homo sapiens_hsa053301.36233601
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.35795100
30Graft-versus-host disease_Homo sapiens_hsa053321.35144727
31Huntingtons disease_Homo sapiens_hsa050161.30586140
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29695163
33Homologous recombination_Homo sapiens_hsa034401.27759627
34Autoimmune thyroid disease_Homo sapiens_hsa053201.27495592
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25869749
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23795922
37Antigen processing and presentation_Homo sapiens_hsa046121.23036304
38Propanoate metabolism_Homo sapiens_hsa006401.21643700
39Purine metabolism_Homo sapiens_hsa002301.19627217
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14807869
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.14533788
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14015526
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.05829685
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03952208
45Regulation of autophagy_Homo sapiens_hsa041400.99934814
46Arachidonic acid metabolism_Homo sapiens_hsa005900.99208518
47Selenocompound metabolism_Homo sapiens_hsa004500.97868006
48Collecting duct acid secretion_Homo sapiens_hsa049660.97599473
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93396773
50Hematopoietic cell lineage_Homo sapiens_hsa046400.93205150
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91414327
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91377080
53Chemical carcinogenesis_Homo sapiens_hsa052040.89541255
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87071519
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84471375
56Basal transcription factors_Homo sapiens_hsa030220.83789328
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83206294
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.78542357
59T cell receptor signaling pathway_Homo sapiens_hsa046600.78102149
60Ether lipid metabolism_Homo sapiens_hsa005650.76036073
61Rheumatoid arthritis_Homo sapiens_hsa053230.74906215
62Retinol metabolism_Homo sapiens_hsa008300.72517480
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71422497
64Peroxisome_Homo sapiens_hsa041460.70067759
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67920806
66Metabolic pathways_Homo sapiens_hsa011000.67827624
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67266323
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.65159761
69Measles_Homo sapiens_hsa051620.63908556
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63263988
71Cardiac muscle contraction_Homo sapiens_hsa042600.63142660
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61349486
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61095374
74ABC transporters_Homo sapiens_hsa020100.60483918
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59724131
76Fatty acid biosynthesis_Homo sapiens_hsa000610.59673723
77Nucleotide excision repair_Homo sapiens_hsa034200.58415394
78Mismatch repair_Homo sapiens_hsa034300.57763355
79Spliceosome_Homo sapiens_hsa030400.57515110
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57394719
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50894355
82Fatty acid metabolism_Homo sapiens_hsa012120.49425598
83Staphylococcus aureus infection_Homo sapiens_hsa051500.47921881
84Fatty acid elongation_Homo sapiens_hsa000620.47489706
85Complement and coagulation cascades_Homo sapiens_hsa046100.45992535
86Fat digestion and absorption_Homo sapiens_hsa049750.45260907
87RNA transport_Homo sapiens_hsa030130.43225777
88beta-Alanine metabolism_Homo sapiens_hsa004100.41026457
89Epstein-Barr virus infection_Homo sapiens_hsa051690.37080884
90Olfactory transduction_Homo sapiens_hsa047400.35152811
91Fatty acid degradation_Homo sapiens_hsa000710.34296012
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.33824350
93Vitamin B6 metabolism_Homo sapiens_hsa007500.30862216
94Ovarian steroidogenesis_Homo sapiens_hsa049130.30596430
95Herpes simplex infection_Homo sapiens_hsa051680.30388170
96Mineral absorption_Homo sapiens_hsa049780.30267806
97Fanconi anemia pathway_Homo sapiens_hsa034600.25292246
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24458967
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23466861
100Tyrosine metabolism_Homo sapiens_hsa003500.22765206

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