COX6B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.38989501
2DNA deamination (GO:0045006)5.07349506
3ribosomal small subunit assembly (GO:0000028)4.95943265
4DNA replication initiation (GO:0006270)4.46176514
5viral transcription (GO:0019083)4.41690418
6DNA strand elongation involved in DNA replication (GO:0006271)4.34774896
7ribosomal small subunit biogenesis (GO:0042274)4.32341971
8telomere maintenance via semi-conservative replication (GO:0032201)4.31681088
9translational termination (GO:0006415)4.27794947
10chromatin remodeling at centromere (GO:0031055)4.22562488
11platelet dense granule organization (GO:0060155)4.20997739
12CENP-A containing nucleosome assembly (GO:0034080)4.20371691
13protein localization to chromosome, centromeric region (GO:0071459)4.18365351
14DNA strand elongation (GO:0022616)4.13986157
15mitotic metaphase plate congression (GO:0007080)4.11997471
16DNA replication checkpoint (GO:0000076)4.04962999
17maturation of SSU-rRNA (GO:0030490)4.00857494
18protein localization to kinetochore (GO:0034501)3.95102114
19detection of light stimulus involved in visual perception (GO:0050908)3.87958823
20detection of light stimulus involved in sensory perception (GO:0050962)3.87958823
21histone exchange (GO:0043486)3.87479629
22translational elongation (GO:0006414)3.86906342
23kinetochore organization (GO:0051383)3.84320169
24kinetochore assembly (GO:0051382)3.84153426
25telomere maintenance via recombination (GO:0000722)3.81543518
26detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.79698742
27DNA replication-independent nucleosome assembly (GO:0006336)3.74731852
28DNA replication-independent nucleosome organization (GO:0034724)3.74731852
29fucose catabolic process (GO:0019317)3.74172710
30L-fucose metabolic process (GO:0042354)3.74172710
31L-fucose catabolic process (GO:0042355)3.74172710
32protein-cofactor linkage (GO:0018065)3.71187850
33DNA replication-dependent nucleosome organization (GO:0034723)3.70284169
34DNA replication-dependent nucleosome assembly (GO:0006335)3.70284169
35mitotic sister chromatid segregation (GO:0000070)3.67527346
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.61882126
37preassembly of GPI anchor in ER membrane (GO:0016254)3.56850693
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56744203
39metaphase plate congression (GO:0051310)3.56062939
40cotranslational protein targeting to membrane (GO:0006613)3.54735703
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54649248
42translational initiation (GO:0006413)3.54330836
43meiotic chromosome segregation (GO:0045132)3.53846270
44mitotic recombination (GO:0006312)3.53052549
45protein targeting to ER (GO:0045047)3.51693464
46respiratory chain complex IV assembly (GO:0008535)3.51121610
47protein K6-linked ubiquitination (GO:0085020)3.46846027
48cornea development in camera-type eye (GO:0061303)3.42848345
49mitotic nuclear envelope disassembly (GO:0007077)3.40741142
50water-soluble vitamin biosynthetic process (GO:0042364)3.39855372
51NADH dehydrogenase complex assembly (GO:0010257)3.39576805
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39576805
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.39576805
54cellular protein complex disassembly (GO:0043624)3.38631786
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.37012460
56telomere maintenance via telomere lengthening (GO:0010833)3.35877834
57protein complex biogenesis (GO:0070271)3.35361882
58ribonucleoprotein complex biogenesis (GO:0022613)3.34772461
59viral life cycle (GO:0019058)3.34038253
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32439063
61attachment of spindle microtubules to kinetochore (GO:0008608)3.31997801
62protein localization to endoplasmic reticulum (GO:0070972)3.31389377
63piRNA metabolic process (GO:0034587)3.30744141
64tryptophan catabolic process (GO:0006569)3.29608804
65indole-containing compound catabolic process (GO:0042436)3.29608804
66indolalkylamine catabolic process (GO:0046218)3.29608804
67indolalkylamine metabolic process (GO:0006586)3.28723549
68axoneme assembly (GO:0035082)3.28455413
69cellular response to ATP (GO:0071318)3.26752482
70establishment of integrated proviral latency (GO:0075713)3.24163254
71establishment of chromosome localization (GO:0051303)3.23509086
72response to pheromone (GO:0019236)3.23254943
73rRNA modification (GO:0000154)3.22804596
74cellular ketone body metabolic process (GO:0046950)3.22728926
75neural tube formation (GO:0001841)3.22623695
76mitochondrial respiratory chain complex assembly (GO:0033108)3.20435271
77DNA unwinding involved in DNA replication (GO:0006268)3.17666070
78ribosomal large subunit biogenesis (GO:0042273)3.16144115
79fusion of sperm to egg plasma membrane (GO:0007342)3.15975802
80formation of translation preinitiation complex (GO:0001731)3.14413498
81pseudouridine synthesis (GO:0001522)3.12568697
82nuclear envelope disassembly (GO:0051081)3.12191012
83membrane disassembly (GO:0030397)3.12191012
84spliceosomal snRNP assembly (GO:0000387)3.11691564
85protein complex disassembly (GO:0043241)3.11591502
86cytochrome complex assembly (GO:0017004)3.10051920
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09585966
88nephron tubule morphogenesis (GO:0072078)3.09453555
89nephron epithelium morphogenesis (GO:0072088)3.09453555
90mitotic chromosome condensation (GO:0007076)3.08889917
91ribosome biogenesis (GO:0042254)3.08504550
92rRNA processing (GO:0006364)3.08420150
93binding of sperm to zona pellucida (GO:0007339)3.06819649
94motile cilium assembly (GO:0044458)3.04235261
95sister chromatid segregation (GO:0000819)3.03856465
96microtubule depolymerization (GO:0007019)3.03467560
97meiotic cell cycle (GO:0051321)3.02836429
98heme biosynthetic process (GO:0006783)3.02012084
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01809546
100transcription-coupled nucleotide-excision repair (GO:0006283)3.01488483
101chromatin assembly or disassembly (GO:0006333)3.00753776
102rRNA metabolic process (GO:0016072)3.00133653
103cilium or flagellum-dependent cell motility (GO:0001539)2.99492485
104axonemal dynein complex assembly (GO:0070286)2.99291318
105synaptic transmission, cholinergic (GO:0007271)2.98421424
106regulation of double-strand break repair via homologous recombination (GO:0010569)2.97582608
107kynurenine metabolic process (GO:0070189)2.96577451
108sperm-egg recognition (GO:0035036)2.96008970
109reciprocal DNA recombination (GO:0035825)2.95335195
110reciprocal meiotic recombination (GO:0007131)2.95335195
111organic cation transport (GO:0015695)2.95087392
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94698333
113protein localization to chromosome (GO:0034502)2.94324144
114regulation of spindle organization (GO:0090224)2.93452794
115dopamine transport (GO:0015872)2.93415925
116regulation of nuclear cell cycle DNA replication (GO:0033262)2.93141378
117negative regulation of telomere maintenance (GO:0032205)2.92843840
118neuronal action potential (GO:0019228)2.92756107
119nuclear-transcribed mRNA catabolic process (GO:0000956)2.92483500
120ATP synthesis coupled proton transport (GO:0015986)2.90397568
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90397568
122macromolecular complex disassembly (GO:0032984)2.90350409
123protoporphyrinogen IX metabolic process (GO:0046501)2.90201882
124protoporphyrinogen IX biosynthetic process (GO:0006782)2.89800065
125kidney morphogenesis (GO:0060993)2.89723823
126regulation of action potential (GO:0098900)2.88865390
127photoreceptor cell development (GO:0042461)2.88319590
128regulation of histone H3-K9 methylation (GO:0051570)2.87573565
129maturation of 5.8S rRNA (GO:0000460)2.87396992
130deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87007535
131ketone body metabolic process (GO:1902224)2.86912697
132meiosis I (GO:0007127)2.86360388
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85583839
134epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85470342
135mismatch repair (GO:0006298)2.84039288
136chromosome condensation (GO:0030261)2.83899759
137DNA methylation involved in gamete generation (GO:0043046)2.83045326
138mitotic cell cycle arrest (GO:0071850)2.82133905
139male meiosis I (GO:0007141)2.82001933
140epithelial cilium movement (GO:0003351)2.81433610
141regulation of chromosome segregation (GO:0051983)2.81232272
142termination of RNA polymerase II transcription (GO:0006369)2.81082252
143positive regulation of chromosome segregation (GO:0051984)2.80641314
144chromosome segregation (GO:0007059)2.80511261
145spliceosomal complex assembly (GO:0000245)2.80169427
146auditory receptor cell stereocilium organization (GO:0060088)2.79868751
147male meiosis (GO:0007140)2.79211982
148mRNA catabolic process (GO:0006402)2.79188341
149synaptonemal complex assembly (GO:0007130)2.78514073
150tryptophan metabolic process (GO:0006568)2.78484505
151translation (GO:0006412)2.78235669
152estrogen biosynthetic process (GO:0006703)2.76992009
153positive regulation of defense response to virus by host (GO:0002230)2.75072623
154spinal cord motor neuron differentiation (GO:0021522)2.74955692
155transepithelial transport (GO:0070633)2.74508275
156protein polyglutamylation (GO:0018095)2.73144472
157L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70346412
158mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69841618
159negative regulation of transcription regulatory region DNA binding (GO:2000678)2.69424791
160GPI anchor metabolic process (GO:0006505)2.69243885
161somite development (GO:0061053)2.67343834
162regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.64064581
163regulation of mitotic spindle checkpoint (GO:1903504)2.64064581
164mannosylation (GO:0097502)2.64059283
165adaptation of signaling pathway (GO:0023058)2.60387879
166tRNA modification (GO:0006400)2.60339449
167rhodopsin mediated signaling pathway (GO:0016056)2.59225802
168photoreceptor cell maintenance (GO:0045494)2.56849415
169regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55948700
170eye photoreceptor cell development (GO:0042462)2.55303492
171multicellular organism reproduction (GO:0032504)2.53608249
172regulation of hexokinase activity (GO:1903299)2.53135079
173regulation of glucokinase activity (GO:0033131)2.53135079
174sulfation (GO:0051923)2.52960379
175protein localization to cilium (GO:0061512)2.52817339
176cilium morphogenesis (GO:0060271)2.51681262
177gamma-aminobutyric acid transport (GO:0015812)2.51206054
178regulation of translation, ncRNA-mediated (GO:0045974)2.50296866
179negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50296866
180negative regulation of translation, ncRNA-mediated (GO:0040033)2.50296866
181amine catabolic process (GO:0009310)2.50007542
182cellular biogenic amine catabolic process (GO:0042402)2.50007542
183tRNA processing (GO:0008033)2.48965757
184regulation of hippo signaling (GO:0035330)2.48389905
185C-terminal protein amino acid modification (GO:0018410)2.47948633
186anterograde synaptic vesicle transport (GO:0048490)2.47367654
187positive regulation of gastrulation (GO:2000543)2.46572541
188establishment of protein localization to mitochondrial membrane (GO:0090151)2.45959560
189inner ear receptor stereocilium organization (GO:0060122)2.45934133
190nonmotile primary cilium assembly (GO:0035058)2.44120161
191regulation of skeletal muscle contraction (GO:0014819)2.43954372
192C-terminal protein lipidation (GO:0006501)2.43513879
193indole-containing compound metabolic process (GO:0042430)2.43506417
194cAMP catabolic process (GO:0006198)2.43269367
195purinergic nucleotide receptor signaling pathway (GO:0035590)2.42342856
196regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.41971312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.58348382
2ZNF274_21170338_ChIP-Seq_K562_Hela4.11303101
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.06220771
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.05676020
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.71630468
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64006092
7VDR_22108803_ChIP-Seq_LS180_Human3.52309122
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50311120
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.47609939
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.44892190
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93658615
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85611699
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81812982
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.78170227
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68945456
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65184213
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.60316360
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.57283749
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43053492
20EZH2_22144423_ChIP-Seq_EOC_Human2.41422718
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41195512
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37513516
23XRN2_22483619_ChIP-Seq_HELA_Human2.20821843
24IGF1R_20145208_ChIP-Seq_DFB_Human2.19400371
25GBX2_23144817_ChIP-Seq_PC3_Human2.19362859
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17649379
27VDR_23849224_ChIP-Seq_CD4+_Human2.11841305
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11722567
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03323681
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01186247
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.99605928
32EWS_26573619_Chip-Seq_HEK293_Human1.98987262
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94527974
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89878501
35FUS_26573619_Chip-Seq_HEK293_Human1.88796164
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85874405
37AR_21909140_ChIP-Seq_LNCAP_Human1.85860822
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85783536
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85589742
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84390594
41DCP1A_22483619_ChIP-Seq_HELA_Human1.83293996
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.83111170
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81939942
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.81913820
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81793198
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80634277
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80237359
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78203036
49GABP_19822575_ChIP-Seq_HepG2_Human1.77715388
50FOXP3_21729870_ChIP-Seq_TREG_Human1.77699955
51TP53_22573176_ChIP-Seq_HFKS_Human1.75258715
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.74049818
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72729484
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69867466
55TTF2_22483619_ChIP-Seq_HELA_Human1.69408343
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.68513466
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67097057
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66486228
59P300_19829295_ChIP-Seq_ESCs_Human1.65953763
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63830390
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60845495
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60101256
63* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59888119
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.58633712
65IRF1_19129219_ChIP-ChIP_H3396_Human1.55427133
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55300117
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53811610
68BCAT_22108803_ChIP-Seq_LS180_Human1.52751559
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49363863
70ER_23166858_ChIP-Seq_MCF-7_Human1.49112421
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49038840
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47870768
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.45915232
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45915232
75TAF15_26573619_Chip-Seq_HEK293_Human1.44796639
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43276854
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41637831
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40647925
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39909110
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38360084
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37743389
82* ERA_21632823_ChIP-Seq_H3396_Human1.37361296
83REST_21632747_ChIP-Seq_MESCs_Mouse1.36878734
84* GATA3_21878914_ChIP-Seq_MCF-7_Human1.36133886
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35500044
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35014141
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33179032
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.32704530
89NCOR_22424771_ChIP-Seq_293T_Human1.32092290
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31311859
91* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31014185
92* MYC_19829295_ChIP-Seq_ESCs_Human1.30591999
93ELK1_19687146_ChIP-ChIP_HELA_Human1.29313837
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27870855
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26852913
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26791787
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26147958
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25997690
99KDM5A_27292631_Chip-Seq_BREAST_Human1.25104427
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24741037
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22955136
102ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22785215
103SOX2_19829295_ChIP-Seq_ESCs_Human1.22490240
104NANOG_19829295_ChIP-Seq_ESCs_Human1.22490240
105HOXB7_26014856_ChIP-Seq_BT474_Human1.22198029
106P53_21459846_ChIP-Seq_SAOS-2_Human1.21957005
107TAF2_19829295_ChIP-Seq_ESCs_Human1.21318738
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20937841
109CIITA_25753668_ChIP-Seq_RAJI_Human1.20906695
110RNF2_27304074_Chip-Seq_NSC_Mouse1.19211808
111NANOG_20526341_ChIP-Seq_ESCs_Human1.19156273
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18525986
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.17117406
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16201349
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15436115
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14993387
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14716353
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14060530
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13707983
120CBP_20019798_ChIP-Seq_JUKART_Human1.13707983
121AR_20517297_ChIP-Seq_VCAP_Human1.11534454
122AR_25329375_ChIP-Seq_VCAP_Human1.10622863
123EZH2_27294783_Chip-Seq_ESCs_Mouse1.10402171
124RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10251910
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09522004
126* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08513507
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07045754
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06343237
129TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06224308
130SCL_19346495_ChIP-Seq_HPC-7_Human1.05208533
131MYC_22102868_ChIP-Seq_BL_Human1.04946827
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04820366
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04630445
134STAT3_23295773_ChIP-Seq_U87_Human1.03728534
135OCT4_20526341_ChIP-Seq_ESCs_Human1.03647711
136TCF4_22108803_ChIP-Seq_LS180_Human1.03407705
137KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03226940
138REST_18959480_ChIP-ChIP_MESCs_Mouse1.03117472
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03097281
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03097281
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02688425
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02216361
143SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01844788
144MYC_18940864_ChIP-ChIP_HL60_Human1.01742031
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01251768
146CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01205631
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00646300
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00453013
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00229920
150SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00124644
151E2F1_20622854_ChIP-Seq_HELA_Human0.99528826
152CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99384808
153KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99365566
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99290601
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.98965043
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98242770
157AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98003789
158VDR_21846776_ChIP-Seq_THP-1_Human0.97730451
159RUNX2_22187159_ChIP-Seq_PCA_Human0.97615549
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97123628
161EZH2_27304074_Chip-Seq_ESCs_Mouse0.96942726
162SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96620841
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96426306
164NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95733769
165JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95675880
166* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94944799
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.94359720
168RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91933835
169TP63_19390658_ChIP-ChIP_HaCaT_Human0.91871341
170KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91792469
171KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91792469
172KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91792469
173CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91470476
174KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87172324
175NOTCH1_21737748_ChIP-Seq_TLL_Human0.84685155
176PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84569969
177TFEB_21752829_ChIP-Seq_HELA_Human0.84464781
178SPI1_23547873_ChIP-Seq_NB4_Human0.83441997
179PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82771580
180SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80285526
181GATA1_26923725_Chip-Seq_HPCs_Mouse0.80164123
182GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80107162
183SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78516724
184NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77998341
185NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77657403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.59689227
2MP0010094_abnormal_chromosome_stability4.36197322
3MP0008057_abnormal_DNA_replication4.32202703
4MP0003111_abnormal_nucleus_morphology4.24811745
5MP0004957_abnormal_blastocyst_morpholog4.00317193
6MP0003077_abnormal_cell_cycle3.86344363
7MP0005410_abnormal_fertilization3.37965585
8MP0008058_abnormal_DNA_repair3.20160997
9MP0008007_abnormal_cellular_replicative2.86704995
10MP0001986_abnormal_taste_sensitivity2.83626997
11MP0003656_abnormal_erythrocyte_physiolo2.64445169
12MP0008877_abnormal_DNA_methylation2.58203647
13MP0005551_abnormal_eye_electrophysiolog2.46980998
14MP0001968_abnormal_touch/_nociception2.45130610
15MP0001929_abnormal_gametogenesis2.41699486
16MP0001545_abnormal_hematopoietic_system2.40129991
17MP0005397_hematopoietic_system_phenotyp2.40129991
18MP0008932_abnormal_embryonic_tissue2.35611078
19MP0004147_increased_porphyrin_level2.29934621
20MP0002653_abnormal_ependyma_morphology2.23596314
21MP0002396_abnormal_hematopoietic_system2.19257328
22MP0002210_abnormal_sex_determination2.16675759
23MP0008875_abnormal_xenobiotic_pharmacok2.13432622
24MP0002638_abnormal_pupillary_reflex2.04987948
25MP0006072_abnormal_retinal_apoptosis2.03737250
26MP0000490_abnormal_crypts_of2.02582490
27MP0003786_premature_aging2.02242208
28MP0005084_abnormal_gallbladder_morpholo2.01612147
29MP0005377_hearing/vestibular/ear_phenot2.00091153
30MP0003878_abnormal_ear_physiology2.00091153
31MP0006292_abnormal_olfactory_placode2.00073595
32MP0002928_abnormal_bile_duct1.99473020
33MP0000350_abnormal_cell_proliferation1.98205200
34MP0005645_abnormal_hypothalamus_physiol1.96354653
35MP0003195_calcinosis1.94417443
36MP0001145_abnormal_male_reproductive1.91238714
37MP0003806_abnormal_nucleotide_metabolis1.91104926
38MP0003718_maternal_effect1.90701544
39MP0003698_abnormal_male_reproductive1.89756811
40MP0002736_abnormal_nociception_after1.85150336
41MP0001730_embryonic_growth_arrest1.83813716
42MP0005171_absent_coat_pigmentation1.80305318
43MP0005253_abnormal_eye_physiology1.80290595
44MP0002277_abnormal_respiratory_mucosa1.77075048
45MP0004885_abnormal_endolymph1.75836070
46MP0004043_abnormal_pH_regulation1.75050124
47MP0000653_abnormal_sex_gland1.73755654
48MP0008872_abnormal_physiological_respon1.73211834
49MP0002837_dystrophic_cardiac_calcinosis1.70353310
50MP0002132_abnormal_respiratory_system1.69850755
51MP0002735_abnormal_chemical_nociception1.67283676
52MP0005423_abnormal_somatic_nervous1.65108341
53MP0004142_abnormal_muscle_tone1.63523256
54MP0001502_abnormal_circadian_rhythm1.63480301
55MP0002876_abnormal_thyroid_physiology1.59786400
56MP0009745_abnormal_behavioral_response1.58790764
57MP0000313_abnormal_cell_death1.51494816
58MP0003880_abnormal_central_pattern1.50783410
59MP0001697_abnormal_embryo_size1.48020202
60MP0000631_abnormal_neuroendocrine_gland1.46776753
61MP0006276_abnormal_autonomic_nervous1.44465935
62MP0002272_abnormal_nervous_system1.43861373
63MP0004133_heterotaxia1.42706203
64MP0003123_paternal_imprinting1.40680014
65MP0002019_abnormal_tumor_incidence1.40195639
66MP0004808_abnormal_hematopoietic_stem1.40055244
67MP0010307_abnormal_tumor_latency1.39974192
68MP0003186_abnormal_redox_activity1.39118583
69MP0001501_abnormal_sleep_pattern1.38969678
70MP0001485_abnormal_pinna_reflex1.37935316
71MP0005380_embryogenesis_phenotype1.37855261
72MP0001672_abnormal_embryogenesis/_devel1.37855261
73MP0005083_abnormal_biliary_tract1.36182307
74MP0002085_abnormal_embryonic_tissue1.35139007
75MP0005646_abnormal_pituitary_gland1.32815409
76MP0002080_prenatal_lethality1.31737948
77MP0002161_abnormal_fertility/fecundity1.31211057
78MP0001293_anophthalmia1.28459480
79MP0001486_abnormal_startle_reflex1.28332700
80MP0003787_abnormal_imprinting1.27970267
81MP0001970_abnormal_pain_threshold1.26562911
82MP0002733_abnormal_thermal_nociception1.24340355
83MP0008789_abnormal_olfactory_epithelium1.23540315
84MP0002102_abnormal_ear_morphology1.22297889
85MP0002084_abnormal_developmental_patter1.21657958
86MP0002909_abnormal_adrenal_gland1.21624855
87MP0009333_abnormal_splenocyte_physiolog1.21585613
88MP0001756_abnormal_urination1.17798099
89MP0002086_abnormal_extraembryonic_tissu1.17215798
90MP0001905_abnormal_dopamine_level1.16703103
91MP0002572_abnormal_emotion/affect_behav1.16663860
92MP0010386_abnormal_urinary_bladder1.15521375
93MP0009379_abnormal_foot_pigmentation1.14978289
94MP0001919_abnormal_reproductive_system1.14876329
95MP0006054_spinal_hemorrhage1.14346548
96MP0004742_abnormal_vestibular_system1.13683512
97MP0000026_abnormal_inner_ear1.13448381
98MP0003984_embryonic_growth_retardation1.13302347
99MP0002160_abnormal_reproductive_system1.12027385
100MP0000427_abnormal_hair_cycle1.10825238
101MP0008995_early_reproductive_senescence1.09525294
102MP0002751_abnormal_autonomic_nervous1.09105659
103MP0001873_stomach_inflammation1.08728514
104MP0006036_abnormal_mitochondrial_physio1.08564752
105MP0002088_abnormal_embryonic_growth/wei1.07652888
106MP0003137_abnormal_impulse_conducting1.07460129
107MP0009046_muscle_twitch1.06865713
108MP0001984_abnormal_olfaction1.06204807
109MP0005075_abnormal_melanosome_morpholog1.06137574
110MP0001119_abnormal_female_reproductive1.02657044
111MP0002234_abnormal_pharynx_morphology1.02554905
112MP0002557_abnormal_social/conspecific_i1.00150110
113MP0010352_gastrointestinal_tract_polyps0.99108607
114MP0002254_reproductive_system_inflammat0.98907826
115MP0002398_abnormal_bone_marrow0.98830394
116MP0005332_abnormal_amino_acid0.98746047
117MP0002184_abnormal_innervation0.97435909
118MP0003119_abnormal_digestive_system0.96523803
119MP0003315_abnormal_perineum_morphology0.95465015
120MP0004019_abnormal_vitamin_homeostasis0.94905448
121MP0000689_abnormal_spleen_morphology0.93262333
122MP0005195_abnormal_posterior_eye0.93190563
123MP0002722_abnormal_immune_system0.91602939
124MP0001324_abnormal_eye_pigmentation0.90687785
125MP0000778_abnormal_nervous_system0.90521603
126MP0002064_seizures0.90129063
127MP0003136_yellow_coat_color0.88774588
128MP0004215_abnormal_myocardial_fiber0.88161597
129MP0002752_abnormal_somatic_nervous0.87473804
130MP0004197_abnormal_fetal_growth/weight/0.87379572
131MP0001963_abnormal_hearing_physiology0.86501571
132MP0000358_abnormal_cell_content/0.85876990
133MP0004264_abnormal_extraembryonic_tissu0.85492871
134MP0002067_abnormal_sensory_capabilities0.84840255
135MP0005167_abnormal_blood-brain_barrier0.84712078
136MP0000372_irregular_coat_pigmentation0.83317487
137MP0000703_abnormal_thymus_morphology0.82940802
138MP0000230_abnormal_systemic_arterial0.82931590
139MP0000858_altered_metastatic_potential0.82568246
140MP0005394_taste/olfaction_phenotype0.82018927
141MP0005499_abnormal_olfactory_system0.82018927
142MP0003699_abnormal_female_reproductive0.81879056
143MP0001849_ear_inflammation0.81787375
144MP0005085_abnormal_gallbladder_physiolo0.81110433
145MP0003122_maternal_imprinting0.80592915
146MP0002063_abnormal_learning/memory/cond0.80323116
147MP0000538_abnormal_urinary_bladder0.80030912
148MP0003635_abnormal_synaptic_transmissio0.78380625
149MP0003567_abnormal_fetal_cardiomyocyte0.78075708
150MP0009278_abnormal_bone_marrow0.77901540
151MP0000566_synostosis0.77583577
152MP0000383_abnormal_hair_follicle0.77337835
153MP0005266_abnormal_metabolism0.77151458
154MP0005174_abnormal_tail_pigmentation0.76445961
155MP0002429_abnormal_blood_cell0.76040330
156MP0005389_reproductive_system_phenotype0.73678342
157MP0003011_delayed_dark_adaptation0.72363305
158MP0003763_abnormal_thymus_physiology0.71789147
159MP0003890_abnormal_embryonic-extraembry0.71149686
160MP0003941_abnormal_skin_development0.71024322
161MP0001915_intracranial_hemorrhage0.65778152
162MP0003121_genomic_imprinting0.64133481
163MP0003646_muscle_fatigue0.63192595
164MP0005384_cellular_phenotype0.62804135
165MP0005501_abnormal_skin_physiology0.62740611
166MP0002938_white_spotting0.60501287
167MP0006035_abnormal_mitochondrial_morpho0.59900387
168MP0001853_heart_inflammation0.59081460
169MP0002249_abnormal_larynx_morphology0.58845230
170MP0000477_abnormal_intestine_morphology0.58767141
171MP0005621_abnormal_cell_physiology0.57178934
172MP0010030_abnormal_orbit_morphology0.56387653
173MP0002095_abnormal_skin_pigmentation0.55997238
174MP0002405_respiratory_system_inflammati0.55783860
175MP0002282_abnormal_trachea_morphology0.52314459
176MP0005395_other_phenotype0.52227893
177MP0000716_abnormal_immune_system0.51369038
178MP0002092_abnormal_eye_morphology0.50478932
179MP0003937_abnormal_limbs/digits/tail_de0.50006868
180MP0001286_abnormal_eye_development0.49842736

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)6.01670780
2Abnormality of cells of the erythroid lineage (HP:0012130)5.98447632
3Abnormality of the heme biosynthetic pathway (HP:0010472)5.63769404
4Birth length less than 3rd percentile (HP:0003561)4.81410911
5Reticulocytopenia (HP:0001896)4.69407401
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.58840164
7Aplastic anemia (HP:0001915)4.51066564
8Congenital stationary night blindness (HP:0007642)4.30146751
9Breast hypoplasia (HP:0003187)4.10974276
10Chromsome breakage (HP:0040012)3.95246323
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.85215902
12Abnormality of midbrain morphology (HP:0002418)3.77549918
13Molar tooth sign on MRI (HP:0002419)3.77549918
14Attenuation of retinal blood vessels (HP:0007843)3.72866971
15True hermaphroditism (HP:0010459)3.65237220
16Absent/shortened dynein arms (HP:0200106)3.45852182
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.45852182
18Pallor (HP:0000980)3.41725203
19Type II lissencephaly (HP:0007260)3.36294832
20Oral leukoplakia (HP:0002745)3.35939943
21Polydipsia (HP:0001959)3.33488730
22Abnormal drinking behavior (HP:0030082)3.33488730
23Chronic hepatic failure (HP:0100626)3.32711644
24Abnormal respiratory motile cilium morphology (HP:0005938)3.16382716
25Abnormal respiratory epithelium morphology (HP:0012253)3.16382716
26Meckel diverticulum (HP:0002245)3.15951196
27Abnormality of the preputium (HP:0100587)3.10864433
28Abnormality of the ileum (HP:0001549)3.09135969
29Abnormal respiratory motile cilium physiology (HP:0012261)3.08559768
30Macrocytic anemia (HP:0001972)3.03801040
31Supernumerary spleens (HP:0009799)3.02730849
32Abnormality of chromosome stability (HP:0003220)2.98670638
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.96449629
34Abnormality of the renal medulla (HP:0100957)2.95641141
35Myelodysplasia (HP:0002863)2.92703741
36Patellar aplasia (HP:0006443)2.92081532
37Lipid accumulation in hepatocytes (HP:0006561)2.91732565
38Tubular atrophy (HP:0000092)2.83778289
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82438015
40Chronic bronchitis (HP:0004469)2.80184528
4111 pairs of ribs (HP:0000878)2.79065135
42Increased hepatocellular lipid droplets (HP:0006565)2.78870571
43Selective tooth agenesis (HP:0001592)2.77824020
44Abolished electroretinogram (ERG) (HP:0000550)2.76167364
45Abnormality of reticulocytes (HP:0004312)2.75453364
46Duodenal stenosis (HP:0100867)2.73917165
47Small intestinal stenosis (HP:0012848)2.73917165
48Aplasia/Hypoplasia of the patella (HP:0006498)2.70285598
49Abnormal rod and cone electroretinograms (HP:0008323)2.69656550
50Rhinitis (HP:0012384)2.69288767
51Cerebellar dysplasia (HP:0007033)2.66339683
52Polyuria (HP:0000103)2.65129161
53Abnormality of the renal cortex (HP:0011035)2.64367843
54Cystic liver disease (HP:0006706)2.61759892
55Abnormal spermatogenesis (HP:0008669)2.58004534
56Decreased central vision (HP:0007663)2.57275951
57Mitochondrial inheritance (HP:0001427)2.57267608
58Absent thumb (HP:0009777)2.55791634
59Impulsivity (HP:0100710)2.55026277
60Medulloblastoma (HP:0002885)2.51951348
61Bone marrow hypocellularity (HP:0005528)2.49234431
62Carpal bone hypoplasia (HP:0001498)2.49006274
63Medial flaring of the eyebrow (HP:0010747)2.45919670
64Duplicated collecting system (HP:0000081)2.42382743
65Sloping forehead (HP:0000340)2.41119054
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39780149
67Increased CSF lactate (HP:0002490)2.38019595
68Hypomagnesemia (HP:0002917)2.37896684
69Renal Fanconi syndrome (HP:0001994)2.37590235
70Bony spicule pigmentary retinopathy (HP:0007737)2.37235416
71Abnormality of the anterior horn cell (HP:0006802)2.36507308
72Degeneration of anterior horn cells (HP:0002398)2.36507308
73Acute necrotizing encephalopathy (HP:0006965)2.36490841
74Sclerocornea (HP:0000647)2.35718481
75Retinal dysplasia (HP:0007973)2.31666187
76Abnormality of abdominal situs (HP:0011620)2.31230508
77Abdominal situs inversus (HP:0003363)2.31230508
78Optic disc pallor (HP:0000543)2.29535640
79Lissencephaly (HP:0001339)2.28857088
80Rough bone trabeculation (HP:0100670)2.28450982
81Microretrognathia (HP:0000308)2.27605020
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26565691
83Infertility (HP:0000789)2.25594282
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24615271
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24615271
86Absent radius (HP:0003974)2.24351344
87Abnormal ciliary motility (HP:0012262)2.23321196
88Abnormal biliary tract physiology (HP:0012439)2.22615803
89Bile duct proliferation (HP:0001408)2.22615803
90Poikilocytosis (HP:0004447)2.21592400
91Pancytopenia (HP:0001876)2.21464141
92Triphalangeal thumb (HP:0001199)2.20655539
93Abnormality of the pons (HP:0007361)2.20151452
94Nasal polyposis (HP:0100582)2.19515269
95Abnormality of the duodenum (HP:0002246)2.19374209
96Male pseudohermaphroditism (HP:0000037)2.18997284
97Chorioretinal atrophy (HP:0000533)2.18339025
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18086997
99Abnormal albumin level (HP:0012116)2.17719095
100Hypoalbuminemia (HP:0003073)2.17719095
101Muscle fiber atrophy (HP:0100295)2.17671036
102Mesangial abnormality (HP:0001966)2.17414391
103Decreased circulating renin level (HP:0003351)2.16522346
104Male infertility (HP:0003251)2.14552428
105Abnormal urine output (HP:0012590)2.14161574
106Nephroblastoma (Wilms tumor) (HP:0002667)2.13536820
107Abnormality of the renal collecting system (HP:0004742)2.13439360
108Abnormality of alanine metabolism (HP:0010916)2.12310976
109Hyperalaninemia (HP:0003348)2.12310976
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12310976
111Clubbing of toes (HP:0100760)2.10793648
112Type I transferrin isoform profile (HP:0003642)2.10594800
113Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10277186
114Absent forearm bone (HP:0003953)2.09540881
115Aplasia involving forearm bones (HP:0009822)2.09540881
116Congenital hepatic fibrosis (HP:0002612)2.08240653
1173-Methylglutaconic aciduria (HP:0003535)2.08137361
118Keratoconus (HP:0000563)2.07796713
119Increased corneal curvature (HP:0100692)2.07796713
120Hypoplasia of the pons (HP:0012110)2.07246387
121Anencephaly (HP:0002323)2.06845247
122Ependymoma (HP:0002888)2.06823859
123Tracheoesophageal fistula (HP:0002575)2.06806657
124Short middle phalanx of the 5th finger (HP:0004220)2.06775270
125Rib fusion (HP:0000902)2.06512291
126Acute encephalopathy (HP:0006846)2.06465105
127Cerebral hypomyelination (HP:0006808)2.06251285
128Missing ribs (HP:0000921)2.05823918
129Hyperglycinuria (HP:0003108)2.05619143
130Pendular nystagmus (HP:0012043)2.05014191
131Occipital encephalocele (HP:0002085)2.04827042
132Premature ovarian failure (HP:0008209)2.04758143
133Large for gestational age (HP:0001520)2.04111960
134Rhabdomyosarcoma (HP:0002859)2.03916439
135Hepatocellular necrosis (HP:0001404)2.03674545
136Abnormal lung lobation (HP:0002101)2.02017690
137Type 2 muscle fiber atrophy (HP:0003554)2.00392099
138Hypothermia (HP:0002045)1.99471482
139Inability to walk (HP:0002540)1.97458134
140Secondary amenorrhea (HP:0000869)1.97066132
141Progressive inability to walk (HP:0002505)1.96766318
142Ectopic kidney (HP:0000086)1.95980152
143Embryonal renal neoplasm (HP:0011794)1.95478359
144Acute lymphatic leukemia (HP:0006721)1.95127859
145Basal cell carcinoma (HP:0002671)1.94731885
146Thrombocytosis (HP:0001894)1.94184943
147Premature graying of hair (HP:0002216)1.93806015
148Abnormal mitochondria in muscle tissue (HP:0008316)1.92017794
149Cleft eyelid (HP:0000625)1.91724766
150Optic nerve hypoplasia (HP:0000609)1.89182404
151Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88312126
152Abnormality of renal excretion (HP:0011036)1.88274752
153Multiple enchondromatosis (HP:0005701)1.88020587
154Progressive macrocephaly (HP:0004481)1.87779623
155Congenital, generalized hypertrichosis (HP:0004540)1.86958509
156Pancreatic cysts (HP:0001737)1.86727638
157Gait imbalance (HP:0002141)1.86702183
158Tetany (HP:0001281)1.85988368
159Colon cancer (HP:0003003)1.85907760
160Increased serum lactate (HP:0002151)1.84787231
161Abnormality of the nasal mucosa (HP:0000433)1.84717856
162Horseshoe kidney (HP:0000085)1.84598701
163Hyperventilation (HP:0002883)1.84257414
164Azoospermia (HP:0000027)1.83945865
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.83852032
166Pancreatic fibrosis (HP:0100732)1.83187198
167Squamous cell carcinoma (HP:0002860)1.83074501
168Constricted visual fields (HP:0001133)1.81756264
169Exertional dyspnea (HP:0002875)1.81614854
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.80096175
171Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79875199
172Asplenia (HP:0001746)1.79653784
173Bronchiectasis (HP:0002110)1.79560506
174Congenital primary aphakia (HP:0007707)1.79489742
175Aplasia/hypoplasia of the uterus (HP:0008684)1.79053212
176Nephronophthisis (HP:0000090)1.78508911
177Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76476388
178Furrowed tongue (HP:0000221)1.76001737
179Postaxial foot polydactyly (HP:0001830)1.75654051
180Hepatic necrosis (HP:0002605)1.75572551
181Methylmalonic aciduria (HP:0012120)1.75061774
182Testicular atrophy (HP:0000029)1.73762070
183Tachypnea (HP:0002789)1.72085959
184Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69487437
185Glycosuria (HP:0003076)1.69380256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.31722074
2BUB13.97826758
3MAPK153.78481404
4CDC73.75268712
5FRK3.51996632
6ADRBK23.42028921
7WNK43.25629684
8NEK23.06285419
9BRSK22.97619282
10VRK12.72397205
11MAP4K22.70551740
12INSRR2.56937242
13PINK12.55380602
14EIF2AK12.52618526
15BMPR1B2.44751486
16WNK32.43218015
17PLK42.40573183
18TTK2.37635825
19GRK12.29387715
20NME22.27463854
21DYRK32.26002994
22STK162.23394958
23CDK72.04183720
24PLK12.00236107
25SRPK11.96493349
26TAOK31.88982410
27NUAK11.87456573
28STK391.86992518
29PDK31.86659994
30PDK41.86659994
31CHEK21.82954879
32ACVR1B1.82134927
33TNIK1.81904181
34PIM21.78124452
35PNCK1.75234234
36TXK1.74164344
37TLK11.72549808
38MAPK131.69552798
39RPS6KB21.69141835
40BRSK11.67867770
41MAP3K61.67605178
42TESK11.63342096
43MARK11.60486583
44AURKB1.56831748
45ATR1.54532088
46ICK1.52927569
47CDK121.52282905
48CDK81.51959045
49MAP3K41.50712163
50OXSR11.48167503
51MAPKAPK31.41317597
52TIE11.40362782
53STK101.37198460
54STK41.29256123
55EEF2K1.29048177
56CASK1.23778864
57NEK11.22452757
58PIM11.21993944
59PAK31.19677005
60TESK21.19390281
61MUSK1.19227224
62ADRBK11.18922548
63MAP3K81.18321419
64CHEK11.18188832
65AURKA1.17148199
66VRK21.15552189
67BCKDK1.11349991
68TRIM281.09815545
69CCNB11.09186717
70MAP2K71.07653825
71SCYL21.06751790
72CDK41.04600495
73MKNK11.03071747
74PDK20.96960849
75PRKCG0.95161868
76PAK40.93474567
77NME10.93434518
78NTRK20.92392148
79ITK0.90357901
80DYRK20.90294454
81BRAF0.88370155
82PRKCE0.87537766
83ATM0.87119661
84EPHA20.86474927
85MATK0.79308441
86MKNK20.78765347
87PASK0.78707475
88CDK190.78571791
89EIF2AK30.77629506
90PAK10.74880401
91ABL20.74205180
92TGFBR10.72495546
93RAF10.71326297
94DAPK20.70689822
95PLK30.69670702
96CDK20.69107086
97RPS6KA40.68970070
98MAP2K60.68487073
99PBK0.67205835
100PRKD30.66452917
101CSNK2A10.65621619
102MAP3K110.65392641
103FLT30.64375910
104GRK70.61949966
105STK30.60573070
106CSNK1A10.59889943
107CSNK1G20.59471963
108PTK2B0.59234943
109NLK0.59197151
110CSNK1G10.58362667
111CSNK2A20.56879867
112LRRK20.55871770
113LATS20.54631420
114CAMKK20.54567913
115CSNK1G30.54005930
116PRKCQ0.53899908
117PHKG10.53756785
118PHKG20.53756785
119CHUK0.53189605
120PIK3CA0.52963756
121NTRK30.51952384
122MST40.51051230
123IRAK10.50680278
124PRKACA0.50409139
125PKN10.49565751
126CSNK1A1L0.49292628
127EPHA30.48760507
128MAP3K100.48629367
129CDK10.48043181
130TYRO30.46448014
131RPS6KA50.45824990
132CAMK2A0.45173575
133MAP4K10.44681813
134STK110.44071671
135FGFR20.43234117
136MOS0.42494788
137DYRK1B0.41989805
138EPHA40.41330562
139CDK60.40900672
140PRKCI0.39572024
141MAPKAPK50.38454585
142ERBB30.38444284
143BCR0.38417954
144KDR0.37806960
145CAMK10.37298666
146PRKCA0.37262590
147EPHB20.37201460
148ZAK0.36954642
149TSSK60.36945424
150SIK20.36292614
151CLK10.33971231
152EIF2AK20.33456340
153TEC0.33230219
154CSNK1D0.32876006
155IKBKE0.32741366
156PRKCZ0.31680071
157PRKAA10.31469930
158KIT0.31359014
159IKBKB0.30786144
160STK38L0.30654026
161TAF10.30531819
162MAP2K20.29770194
163AKT20.28768675
164ILK0.27441843
165BTK0.26739027
166PAK20.23664836
167TAOK10.22965848
168MAP2K30.21804176
169CSF1R0.21428401
170MAP3K50.21129168

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.07249870
2Ribosome_Homo sapiens_hsa030104.32215973
3Mismatch repair_Homo sapiens_hsa034304.08894798
4Homologous recombination_Homo sapiens_hsa034403.39815271
5RNA polymerase_Homo sapiens_hsa030203.34636104
6Base excision repair_Homo sapiens_hsa034103.14300504
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09936911
8Spliceosome_Homo sapiens_hsa030403.07271173
9Nucleotide excision repair_Homo sapiens_hsa034202.96190117
10Phototransduction_Homo sapiens_hsa047442.85290991
11Fanconi anemia pathway_Homo sapiens_hsa034602.84346729
12Cell cycle_Homo sapiens_hsa041102.79623706
13RNA transport_Homo sapiens_hsa030132.70385049
14Pyrimidine metabolism_Homo sapiens_hsa002402.66591967
15Basal transcription factors_Homo sapiens_hsa030222.61001412
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41596116
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.28869620
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.27508551
19Nitrogen metabolism_Homo sapiens_hsa009102.26844224
20Proteasome_Homo sapiens_hsa030502.26340971
21RNA degradation_Homo sapiens_hsa030182.15228407
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13287800
23Non-homologous end-joining_Homo sapiens_hsa034502.04785482
24Nicotine addiction_Homo sapiens_hsa050332.02331845
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00786576
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93746988
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83112051
28One carbon pool by folate_Homo sapiens_hsa006701.81805146
29p53 signaling pathway_Homo sapiens_hsa041151.79715176
30Butanoate metabolism_Homo sapiens_hsa006501.75129846
31mRNA surveillance pathway_Homo sapiens_hsa030151.54340013
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52604223
33Taste transduction_Homo sapiens_hsa047421.50852426
34Purine metabolism_Homo sapiens_hsa002301.48449581
35Tryptophan metabolism_Homo sapiens_hsa003801.43291334
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42093116
37Caffeine metabolism_Homo sapiens_hsa002321.35334848
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31973889
39Vitamin B6 metabolism_Homo sapiens_hsa007501.24313616
40Huntingtons disease_Homo sapiens_hsa050161.20453986
41* Cardiac muscle contraction_Homo sapiens_hsa042601.18506699
42Systemic lupus erythematosus_Homo sapiens_hsa053221.16724946
43Morphine addiction_Homo sapiens_hsa050321.14029435
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11622647
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.11095609
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08908378
47Peroxisome_Homo sapiens_hsa041461.07037679
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05749166
49Pentose phosphate pathway_Homo sapiens_hsa000301.03553166
50Oocyte meiosis_Homo sapiens_hsa041141.02643367
51Chemical carcinogenesis_Homo sapiens_hsa052040.99820143
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.98774078
53Olfactory transduction_Homo sapiens_hsa047400.97888782
54ABC transporters_Homo sapiens_hsa020100.97049937
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96903153
56Glutathione metabolism_Homo sapiens_hsa004800.96596481
57Sulfur relay system_Homo sapiens_hsa041220.94728611
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.93931768
59Epstein-Barr virus infection_Homo sapiens_hsa051690.91763670
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90796727
61Herpes simplex infection_Homo sapiens_hsa051680.89216791
62Folate biosynthesis_Homo sapiens_hsa007900.85566377
63Regulation of autophagy_Homo sapiens_hsa041400.83704442
64Retinol metabolism_Homo sapiens_hsa008300.83565232
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82811506
66Circadian rhythm_Homo sapiens_hsa047100.81490343
67Parkinsons disease_Homo sapiens_hsa050120.80426477
68Protein export_Homo sapiens_hsa030600.79959568
69Selenocompound metabolism_Homo sapiens_hsa004500.79742631
70Collecting duct acid secretion_Homo sapiens_hsa049660.79058080
71Linoleic acid metabolism_Homo sapiens_hsa005910.78441517
72Propanoate metabolism_Homo sapiens_hsa006400.77914098
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76974126
74Ovarian steroidogenesis_Homo sapiens_hsa049130.76286046
75GABAergic synapse_Homo sapiens_hsa047270.76180298
76Viral carcinogenesis_Homo sapiens_hsa052030.74939320
77Sulfur metabolism_Homo sapiens_hsa009200.72080969
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71498697
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71145248
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71031417
81Serotonergic synapse_Homo sapiens_hsa047260.70462001
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.69856511
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67846674
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66555900
85Arachidonic acid metabolism_Homo sapiens_hsa005900.66381293
86* Oxidative phosphorylation_Homo sapiens_hsa001900.65426293
87Glutamatergic synapse_Homo sapiens_hsa047240.63746126
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63347357
89Circadian entrainment_Homo sapiens_hsa047130.61710263
90Small cell lung cancer_Homo sapiens_hsa052220.60726627
91Biosynthesis of amino acids_Homo sapiens_hsa012300.60687570
92Fat digestion and absorption_Homo sapiens_hsa049750.59929135
93Thyroid cancer_Homo sapiens_hsa052160.59613180
94Steroid biosynthesis_Homo sapiens_hsa001000.57167435
95beta-Alanine metabolism_Homo sapiens_hsa004100.56469594
96Salivary secretion_Homo sapiens_hsa049700.55624522
97Insulin secretion_Homo sapiens_hsa049110.55530514
98HTLV-I infection_Homo sapiens_hsa051660.51638772
99Antigen processing and presentation_Homo sapiens_hsa046120.51505111
100Glycerolipid metabolism_Homo sapiens_hsa005610.49650564
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49502705
102Vitamin digestion and absorption_Homo sapiens_hsa049770.48522950
103Mineral absorption_Homo sapiens_hsa049780.47013437
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46535382
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45715260
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45630450
107Histidine metabolism_Homo sapiens_hsa003400.45156509
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45092222
109Calcium signaling pathway_Homo sapiens_hsa040200.45045038
110N-Glycan biosynthesis_Homo sapiens_hsa005100.43321287
111Bladder cancer_Homo sapiens_hsa052190.42154793
112Ether lipid metabolism_Homo sapiens_hsa005650.40682710
113Graft-versus-host disease_Homo sapiens_hsa053320.39986357
114Cocaine addiction_Homo sapiens_hsa050300.39917426
115TGF-beta signaling pathway_Homo sapiens_hsa043500.39896616
116* Metabolic pathways_Homo sapiens_hsa011000.39042505
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38765555
118Sphingolipid metabolism_Homo sapiens_hsa006000.38190429
119Alcoholism_Homo sapiens_hsa050340.37361355
120MicroRNAs in cancer_Homo sapiens_hsa052060.37255079
121Fructose and mannose metabolism_Homo sapiens_hsa000510.36594444
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36428711
123* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35110203
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.32998526
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32984281
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.32555455
127Apoptosis_Homo sapiens_hsa042100.31566172
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.31226809
129Galactose metabolism_Homo sapiens_hsa000520.31005118
130Notch signaling pathway_Homo sapiens_hsa043300.30934615
131Hematopoietic cell lineage_Homo sapiens_hsa046400.30672404
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30603666
133Acute myeloid leukemia_Homo sapiens_hsa052210.30584962
134Pyruvate metabolism_Homo sapiens_hsa006200.29356920
135Fatty acid degradation_Homo sapiens_hsa000710.27222780
136Carbon metabolism_Homo sapiens_hsa012000.26928997
137Shigellosis_Homo sapiens_hsa051310.24775616
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23383863
139Hepatitis B_Homo sapiens_hsa051610.23184269
140Measles_Homo sapiens_hsa051620.22812474
141Basal cell carcinoma_Homo sapiens_hsa052170.21512528
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21122300
143Other glycan degradation_Homo sapiens_hsa005110.20813138
144Alzheimers disease_Homo sapiens_hsa050100.19823875
145Legionellosis_Homo sapiens_hsa051340.19299186
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15524348
147Colorectal cancer_Homo sapiens_hsa052100.15503216
148Pathways in cancer_Homo sapiens_hsa052000.13582366
149Hedgehog signaling pathway_Homo sapiens_hsa043400.13400040
150Chronic myeloid leukemia_Homo sapiens_hsa052200.12280307
151Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11049582
152Influenza A_Homo sapiens_hsa051640.10830040
153Hippo signaling pathway_Homo sapiens_hsa043900.10161014
154Arginine and proline metabolism_Homo sapiens_hsa003300.10011437
155Primary immunodeficiency_Homo sapiens_hsa053400.08960659
156RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07917124
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06389924
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.06305800
159Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05141219
160Renin-angiotensin system_Homo sapiens_hsa046140.03805461

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