COX6C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.97719692
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.97719692
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.30144223
4* respiratory electron transport chain (GO:0022904)8.35349523
5* electron transport chain (GO:0022900)8.13624753
6ATP biosynthetic process (GO:0006754)5.44418002
7chaperone-mediated protein transport (GO:0072321)5.30567325
8ribosomal small subunit assembly (GO:0000028)5.25090306
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.22413760
10translational elongation (GO:0006414)5.10155127
11purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.04289552
12* hydrogen ion transmembrane transport (GO:1902600)5.03115825
13purine nucleoside triphosphate biosynthetic process (GO:0009145)4.94252295
14protein neddylation (GO:0045116)4.65528398
15viral life cycle (GO:0019058)4.65022383
16inner mitochondrial membrane organization (GO:0007007)4.58369360
17protein complex biogenesis (GO:0070271)4.46934654
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42612558
19mitochondrial respiratory chain complex I assembly (GO:0032981)4.42612558
20NADH dehydrogenase complex assembly (GO:0010257)4.42612558
21* proton transport (GO:0015992)4.41318509
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.39959240
23sequestering of actin monomers (GO:0042989)4.34249488
24* hydrogen transport (GO:0006818)4.33782285
25ribonucleoside triphosphate biosynthetic process (GO:0009201)4.33763484
26translational initiation (GO:0006413)4.28995775
27maturation of SSU-rRNA (GO:0030490)4.15429098
28oxidative phosphorylation (GO:0006119)4.08975599
29axon ensheathment in central nervous system (GO:0032291)4.07251867
30central nervous system myelination (GO:0022010)4.07251867
31mitochondrial respiratory chain complex assembly (GO:0033108)4.02443784
32translation (GO:0006412)4.01271206
33ribosomal large subunit biogenesis (GO:0042273)3.99107380
34proteasome assembly (GO:0043248)3.95276769
35protein complex disassembly (GO:0043241)3.86549192
36protein targeting to membrane (GO:0006612)3.76962778
37macromolecular complex disassembly (GO:0032984)3.74455445
38cytochrome complex assembly (GO:0017004)3.73146215
39nucleoside triphosphate biosynthetic process (GO:0009142)3.66759437
40GTP biosynthetic process (GO:0006183)3.63839977
41ribosomal small subunit biogenesis (GO:0042274)3.50171551
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.48636314
43ATP hydrolysis coupled proton transport (GO:0015991)3.48636314
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.43431296
45termination of RNA polymerase III transcription (GO:0006386)3.43431296
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42543428
47substantia nigra development (GO:0021762)3.41390256
48neuron cell-cell adhesion (GO:0007158)3.30506824
49regulation of oxidative phosphorylation (GO:0002082)3.30432197
50fatty acid elongation (GO:0030497)3.27847127
51negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25930679
52regulation of cellular amino acid metabolic process (GO:0006521)3.25397616
53mitochondrial transport (GO:0006839)3.23007938
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22916271
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.20937711
56viral transcription (GO:0019083)3.14763917
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11850030
58cellular component biogenesis (GO:0044085)3.09790662
59rRNA modification (GO:0000154)3.07844705
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07194442
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05702901
62negative regulation of ligase activity (GO:0051352)3.05702901
63aerobic respiration (GO:0009060)3.04173005
64* generation of precursor metabolites and energy (GO:0006091)3.02879296
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02362075
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02362075
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02362075
68mRNA catabolic process (GO:0006402)3.01486308
69calcium-mediated signaling using intracellular calcium source (GO:0035584)3.01413017
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01121591
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01121591
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01108892
73long-chain fatty acid biosynthetic process (GO:0042759)3.00779761
74translational termination (GO:0006415)3.00502978
75protein-cofactor linkage (GO:0018065)3.00088767
76tricarboxylic acid cycle (GO:0006099)2.99800624
77positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.97226049
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96963360
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96963360
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95546740
81regulation of cell communication by electrical coupling (GO:0010649)2.94181478
82regulation of mitochondrial translation (GO:0070129)2.93712377
83dopamine transport (GO:0015872)2.93674619
84water-soluble vitamin biosynthetic process (GO:0042364)2.92722229
85negative regulation of protein localization to cell surface (GO:2000009)2.92633272
86signal transduction involved in DNA damage checkpoint (GO:0072422)2.89748663
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89748663
88UTP biosynthetic process (GO:0006228)2.89142690
89establishment of protein localization to mitochondrion (GO:0072655)2.87976571
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87339903
91signal transduction involved in cell cycle checkpoint (GO:0072395)2.87080075
92protein targeting to mitochondrion (GO:0006626)2.87005640
93regulation of acyl-CoA biosynthetic process (GO:0050812)2.86199404
94purine nucleoside monophosphate biosynthetic process (GO:0009127)2.85071677
95purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.85071677
96protein localization to mitochondrion (GO:0070585)2.80257149
97establishment of protein localization to membrane (GO:0090150)2.79753660
98regulation of catecholamine metabolic process (GO:0042069)2.78709867
99regulation of dopamine metabolic process (GO:0042053)2.78709867
100cotranslational protein targeting to membrane (GO:0006613)2.77526267
101regulation of cellular respiration (GO:0043457)2.77254435
102neuronal action potential propagation (GO:0019227)2.76897145
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76863736
104protein targeting (GO:0006605)2.75228618
105presynaptic membrane assembly (GO:0097105)2.74290841
106dopamine biosynthetic process (GO:0042416)2.73404768
107organelle disassembly (GO:1903008)2.71409699
108protein targeting to ER (GO:0045047)2.70803659
109RNA catabolic process (GO:0006401)2.69720691
110presynaptic membrane organization (GO:0097090)2.69364005
111platelet dense granule organization (GO:0060155)2.69079467
112intracellular protein transmembrane import (GO:0044743)2.69011510
113spliceosomal complex assembly (GO:0000245)2.66516550
114regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65510271
115spliceosomal snRNP assembly (GO:0000387)2.64880340
116establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63978332
117SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62681316
118cellular response to epinephrine stimulus (GO:0071872)2.62453807
119purine nucleoside biosynthetic process (GO:0042451)2.62255699
120purine ribonucleoside biosynthetic process (GO:0046129)2.62255699
121protein localization to endoplasmic reticulum (GO:0070972)2.62232073
122response to epinephrine (GO:0071871)2.62221816
123mannosylation (GO:0097502)2.62015963
124regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61849628
125UTP metabolic process (GO:0046051)2.60782392
126positive regulation of ligase activity (GO:0051351)2.59346626
127detection of calcium ion (GO:0005513)2.58537156
128regulation of cofactor metabolic process (GO:0051193)2.57676777
129regulation of coenzyme metabolic process (GO:0051196)2.57676777
130regulation of protein kinase A signaling (GO:0010738)2.55808177
131regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.54741916
132regulation of cellular amine metabolic process (GO:0033238)2.54643033
133positive regulation of action potential (GO:0045760)2.54131547
134respiratory chain complex IV assembly (GO:0008535)2.53798552
135nucleoside diphosphate phosphorylation (GO:0006165)2.53654767
136behavioral response to nicotine (GO:0035095)2.52668565
137ubiquinone biosynthetic process (GO:0006744)2.51565101
138quinone biosynthetic process (GO:1901663)2.51565101
139ribonucleoprotein complex biogenesis (GO:0022613)2.51151556
140establishment of protein localization to organelle (GO:0072594)2.50243867
141cellular ketone body metabolic process (GO:0046950)2.48622231
142cellular protein complex disassembly (GO:0043624)2.46058013
143sarcoplasmic reticulum calcium ion transport (GO:0070296)2.45569349
144regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.44541991
145negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.43230358
146negative regulation of calcium ion transmembrane transport (GO:1903170)2.43230358
147succinate metabolic process (GO:0006105)2.42691710
148NADH metabolic process (GO:0006734)2.42291152
149positive regulation of synapse assembly (GO:0051965)2.41443464
150mitochondrion morphogenesis (GO:0070584)2.40960940
151ubiquinone metabolic process (GO:0006743)2.40887767
152neurotransmitter uptake (GO:0001504)2.40784982
153regulation of glutamate secretion (GO:0014048)2.39331064
154cellular respiration (GO:0045333)2.39217012
155neuron recognition (GO:0008038)2.36752546
156mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.5594228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70405457
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.86826512
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93380802
4GBX2_23144817_ChIP-Seq_PC3_Human2.78874407
5ELK1_19687146_ChIP-ChIP_HELA_Human2.71389702
6TAF15_26573619_Chip-Seq_HEK293_Human2.70103172
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.69602089
8VDR_22108803_ChIP-Seq_LS180_Human2.66921225
9* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.51091201
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41512577
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40622583
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39335884
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39134817
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30811700
15* VDR_23849224_ChIP-Seq_CD4+_Human2.22134475
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.19618929
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07998758
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06447259
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03817658
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00395914
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97117144
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96357878
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95846068
24* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94672598
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.94432006
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87425061
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84810827
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84810827
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80647071
30FUS_26573619_Chip-Seq_HEK293_Human1.80143019
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79762763
32TTF2_22483619_ChIP-Seq_HELA_Human1.79261367
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.78590055
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78204679
35MYC_18940864_ChIP-ChIP_HL60_Human1.77879315
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.77780665
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75873043
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.74576631
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73442862
40* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73036078
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72340342
42DCP1A_22483619_ChIP-Seq_HELA_Human1.71411026
43XRN2_22483619_ChIP-Seq_HELA_Human1.66269926
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65286976
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60004048
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.58644884
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56748436
48ER_23166858_ChIP-Seq_MCF-7_Human1.55588141
49* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55409005
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53968249
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53499651
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52378286
53P300_19829295_ChIP-Seq_ESCs_Human1.51117283
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50878780
55REST_21632747_ChIP-Seq_MESCs_Mouse1.50072891
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50059298
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49760917
58* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48692951
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48599604
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.43232257
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42926297
62TP53_22573176_ChIP-Seq_HFKS_Human1.39735921
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39682387
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39498002
65* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38707030
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37594515
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36049619
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35952168
69* EST1_17652178_ChIP-ChIP_JURKAT_Human1.35752360
70GABP_19822575_ChIP-Seq_HepG2_Human1.34122567
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34073651
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33332387
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31731200
74ZNF274_21170338_ChIP-Seq_K562_Hela1.31452274
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25435374
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.24714064
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.24353359
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24138406
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23995990
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.22000421
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21737540
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.21471563
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20631152
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20198758
85AR_21572438_ChIP-Seq_LNCaP_Human1.18484100
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18310229
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17630451
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14911766
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.11836639
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11010366
91SMAD4_21799915_ChIP-Seq_A2780_Human1.10932192
92* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10416613
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.09389587
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09255018
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09088913
96IGF1R_20145208_ChIP-Seq_DFB_Human1.08948315
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08663629
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08170553
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.07997863
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06582682
101* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06375549
102HTT_18923047_ChIP-ChIP_STHdh_Human1.04707093
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04371512
104RNF2_27304074_Chip-Seq_NSC_Mouse1.03854321
105* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03462988
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03208338
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02793897
108TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02635557
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02447333
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01285371
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01080916
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.00289394
113BP1_19119308_ChIP-ChIP_Hs578T_Human1.00096905
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99852880
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99380101
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98770707
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98704646
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98455527
119ELF5_23300383_ChIP-Seq_T47D_Human0.98064269
120JUN_21703547_ChIP-Seq_K562_Human0.97939502
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.97269034
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97269034
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.96218798
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95312172
125SOX2_19829295_ChIP-Seq_ESCs_Human0.93977974
126NANOG_19829295_ChIP-Seq_ESCs_Human0.93977974
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93613075
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93266347
129* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92192685
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91681672
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90676830
132ERG_20517297_ChIP-Seq_VCAP_Human0.90521610
133* PRDM14_20953172_ChIP-Seq_ESCs_Human0.87149015
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86008320
135AR_20517297_ChIP-Seq_VCAP_Human0.85831110
136NCOR_22424771_ChIP-Seq_293T_Human0.85818768
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.85654121
138IRF1_19129219_ChIP-ChIP_H3396_Human0.85150163
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.84487099
140EWS_26573619_Chip-Seq_HEK293_Human0.84457369
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84008071
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.83600774
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83443424
144* TAL1_26923725_Chip-Seq_HPCs_Mouse0.81713474
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.79676181
146RARB_27405468_Chip-Seq_BRAIN_Mouse0.79551853
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78616657
148REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78506680
149SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78055710
150* RUNX2_22187159_ChIP-Seq_PCA_Human0.77937838
151KDM5A_27292631_Chip-Seq_BREAST_Human0.77809316
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77336838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.71016531
2MP0002837_dystrophic_cardiac_calcinosis4.19558339
3MP0009379_abnormal_foot_pigmentation3.30058022
4MP0001529_abnormal_vocalization3.29086265
5MP0000751_myopathy2.61725492
6MP0006276_abnormal_autonomic_nervous2.56629733
7MP0001905_abnormal_dopamine_level2.48465113
8MP0003646_muscle_fatigue2.36442615
9MP0006292_abnormal_olfactory_placode2.35217608
10MP0000372_irregular_coat_pigmentation2.33334828
11MP0004215_abnormal_myocardial_fiber2.30105338
12MP0001440_abnormal_grooming_behavior2.24557059
13MP0009745_abnormal_behavioral_response2.17803724
14MP0001968_abnormal_touch/_nociception2.16207634
15MP0002736_abnormal_nociception_after2.11768386
16MP0002064_seizures2.09023921
17MP0003787_abnormal_imprinting2.08744325
18MP0006036_abnormal_mitochondrial_physio2.08229000
19MP0002272_abnormal_nervous_system2.07456436
20MP0003011_delayed_dark_adaptation2.05704987
21MP0004270_analgesia2.05191116
22MP0003635_abnormal_synaptic_transmissio2.04876486
23MP0004036_abnormal_muscle_relaxation2.02342334
24MP0002938_white_spotting1.98525994
25MP0009046_muscle_twitch1.94776783
26MP0004142_abnormal_muscle_tone1.94025902
27MP0003806_abnormal_nucleotide_metabolis1.93894506
28MP0004859_abnormal_synaptic_plasticity1.88806455
29MP0003186_abnormal_redox_activity1.82953521
30MP0003136_yellow_coat_color1.80084272
31MP0002822_catalepsy1.80018866
32MP0002572_abnormal_emotion/affect_behav1.77654904
33MP0002735_abnormal_chemical_nociception1.76090147
34MP0001486_abnormal_startle_reflex1.76071294
35MP0002734_abnormal_mechanical_nocicepti1.74423726
36MP0008877_abnormal_DNA_methylation1.72861687
37MP0005423_abnormal_somatic_nervous1.72377980
38MP0004084_abnormal_cardiac_muscle1.70519582
39MP0003137_abnormal_impulse_conducting1.70446418
40MP0000749_muscle_degeneration1.70245148
41MP0008995_early_reproductive_senescence1.70053724
42MP0006035_abnormal_mitochondrial_morpho1.66388152
43MP0002653_abnormal_ependyma_morphology1.64771410
44MP0005408_hypopigmentation1.64528309
45MP0005330_cardiomyopathy1.63999266
46MP0000566_synostosis1.63746513
47MP0004145_abnormal_muscle_electrophysio1.62114537
48MP0002063_abnormal_learning/memory/cond1.61483212
49MP0005646_abnormal_pituitary_gland1.60437233
50MP0001970_abnormal_pain_threshold1.58384010
51MP0004043_abnormal_pH_regulation1.57906630
52MP0004924_abnormal_behavior1.55302980
53MP0005386_behavior/neurological_phenoty1.55302980
54MP0003123_paternal_imprinting1.53206821
55MP0004484_altered_response_of1.49722191
56MP0000920_abnormal_myelination1.48658189
57MP0003329_amyloid_beta_deposits1.48244051
58MP0002067_abnormal_sensory_capabilities1.47379302
59MP0008789_abnormal_olfactory_epithelium1.47232653
60MP0002733_abnormal_thermal_nociception1.45411832
61MP0001501_abnormal_sleep_pattern1.45410618
62MP0005409_darkened_coat_color1.42940478
63MP0004742_abnormal_vestibular_system1.38192636
64MP0008875_abnormal_xenobiotic_pharmacok1.37917728
65MP0003718_maternal_effect1.36339740
66MP0003121_genomic_imprinting1.33891471
67MP0002972_abnormal_cardiac_muscle1.33409085
68MP0001485_abnormal_pinna_reflex1.32352317
69MP0000778_abnormal_nervous_system1.30899494
70MP0002332_abnormal_exercise_endurance1.30659788
71MP0005253_abnormal_eye_physiology1.29806964
72MP0002277_abnormal_respiratory_mucosa1.27779928
73MP0004085_abnormal_heartbeat1.27667717
74MP0005620_abnormal_muscle_contractility1.27582254
75MP0000631_abnormal_neuroendocrine_gland1.26871505
76MP0002160_abnormal_reproductive_system1.26273609
77MP0005645_abnormal_hypothalamus_physiol1.25882221
78MP0001919_abnormal_reproductive_system1.24163410
79MP0003950_abnormal_plasma_membrane1.23991691
80MP0005084_abnormal_gallbladder_morpholo1.23742026
81MP0002909_abnormal_adrenal_gland1.22269912
82MP0010030_abnormal_orbit_morphology1.21518204
83MP0000427_abnormal_hair_cycle1.18910642
84MP0005171_absent_coat_pigmentation1.18415948
85MP0005075_abnormal_melanosome_morpholog1.14246181
86MP0006072_abnormal_retinal_apoptosis1.13098393
87MP0001984_abnormal_olfaction1.10252716
88MP0005551_abnormal_eye_electrophysiolog1.10223156
89MP0002184_abnormal_innervation1.09577079
90MP0005535_abnormal_body_temperature1.08519312
91MP0002638_abnormal_pupillary_reflex1.08155603
92MP0010386_abnormal_urinary_bladder1.07238061
93MP0004885_abnormal_endolymph1.07217687
94MP0002090_abnormal_vision1.06870436
95MP0003938_abnormal_ear_development1.06706546
96MP0002106_abnormal_muscle_physiology1.06078573
97MP0001727_abnormal_embryo_implantation1.05751769
98MP0008058_abnormal_DNA_repair1.05376194
99MP0002066_abnormal_motor_capabilities/c1.03200920
100MP0005499_abnormal_olfactory_system1.02688759
101MP0005394_taste/olfaction_phenotype1.02688759
102MP0001188_hyperpigmentation1.02569224
103MP0003195_calcinosis1.02326349
104MP0000747_muscle_weakness1.01732532
105MP0002751_abnormal_autonomic_nervous1.01667127
106MP0001293_anophthalmia1.00823943
107MP0003122_maternal_imprinting1.00711256
108MP0005389_reproductive_system_phenotype0.99640128
109MP0002557_abnormal_social/conspecific_i0.99488152
110MP0004133_heterotaxia0.98560097
111MP0002229_neurodegeneration0.96564713
112MP0005379_endocrine/exocrine_gland_phen0.95187645
113MP0000750_abnormal_muscle_regeneration0.94760909
114MP0008775_abnormal_heart_ventricle0.94305273
115MP0002163_abnormal_gland_morphology0.91700975
116MP0002095_abnormal_skin_pigmentation0.91675156
117MP0005369_muscle_phenotype0.90575917
118MP0002882_abnormal_neuron_morphology0.89216557
119MP0008872_abnormal_physiological_respon0.87222922
120MP0001963_abnormal_hearing_physiology0.87068807
121MP0003315_abnormal_perineum_morphology0.87003653
122MP0002876_abnormal_thyroid_physiology0.86039035
123MP0002102_abnormal_ear_morphology0.85666088
124MP0002210_abnormal_sex_determination0.85555222
125MP0005332_abnormal_amino_acid0.84110653
126MP0003693_abnormal_embryo_hatching0.83809513
127MP0002752_abnormal_somatic_nervous0.83246306
128MP0002234_abnormal_pharynx_morphology0.83104226
129MP0001764_abnormal_homeostasis0.82400445
130MP0006138_congestive_heart_failure0.82305171
131MP0000230_abnormal_systemic_arterial0.81988136
132MP0003786_premature_aging0.81698042
133MP0005451_abnormal_body_composition0.81607648
134MP0001664_abnormal_digestion0.81589578
135MP0009697_abnormal_copulation0.80999379
136MP0005195_abnormal_posterior_eye0.80893814
137MP0001346_abnormal_lacrimal_gland0.80851177
138MP0004087_abnormal_muscle_fiber0.80791670
139MP0000647_abnormal_sebaceous_gland0.80751134
140MP0005385_cardiovascular_system_phenoty0.80323273
141MP0001544_abnormal_cardiovascular_syste0.80323273
142MP0005410_abnormal_fertilization0.79868743
143MP0003638_abnormal_response/metabolism_0.79826456
144MP0000026_abnormal_inner_ear0.79308367
145MP0003634_abnormal_glial_cell0.79132913
146MP0005165_increased_susceptibility_to0.76024946
147MP0000955_abnormal_spinal_cord0.73630381
148MP0000759_abnormal_skeletal_muscle0.71813559
149MP0000462_abnormal_digestive_system0.70814198
150MP0000013_abnormal_adipose_tissue0.70039601
151MP0004147_increased_porphyrin_level0.69469884
152MP0005636_abnormal_mineral_homeostasis0.68237333
153MP0003690_abnormal_glial_cell0.68180020
154MP0004130_abnormal_muscle_cell0.68112634

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.59724139
2Abnormal mitochondria in muscle tissue (HP:0008316)6.89829915
3Progressive macrocephaly (HP:0004481)6.48121929
4Mitochondrial inheritance (HP:0001427)6.38569020
5Acute encephalopathy (HP:0006846)6.34588166
6Increased CSF lactate (HP:0002490)5.42916379
7Hepatocellular necrosis (HP:0001404)5.19383153
8Increased hepatocellular lipid droplets (HP:0006565)5.01796547
9Cerebral edema (HP:0002181)4.73761898
10Hepatic necrosis (HP:0002605)4.65986334
11Lipid accumulation in hepatocytes (HP:0006561)4.60367754
12Renal Fanconi syndrome (HP:0001994)4.25722526
13Increased intramyocellular lipid droplets (HP:0012240)4.08190241
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.05174125
15Optic disc pallor (HP:0000543)4.03496213
16Increased serum pyruvate (HP:0003542)3.98526913
17Abnormality of glycolysis (HP:0004366)3.98526913
18Respiratory failure (HP:0002878)3.95184823
19Leukodystrophy (HP:0002415)3.89873474
20Exercise intolerance (HP:0003546)3.85898042
21Lactic acidosis (HP:0003128)3.67664269
22Increased muscle lipid content (HP:0009058)3.62341554
23Reticulocytopenia (HP:0001896)3.60450582
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.55247100
253-Methylglutaconic aciduria (HP:0003535)3.50589751
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39542286
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39542286
28Congenital, generalized hypertrichosis (HP:0004540)3.30110628
29Muscle hypertrophy of the lower extremities (HP:0008968)3.25252409
30Myokymia (HP:0002411)3.10795591
31Concave nail (HP:0001598)3.08623239
32Increased serum lactate (HP:0002151)3.07017971
33Sudden death (HP:0001699)3.05269358
34Calf muscle hypertrophy (HP:0008981)3.02856570
35Pheochromocytoma (HP:0002666)2.97486362
36Exertional dyspnea (HP:0002875)2.93790064
37Neuroendocrine neoplasm (HP:0100634)2.88540042
38Abnormality of renal resorption (HP:0011038)2.85096029
39Focal motor seizures (HP:0011153)2.84447382
40X-linked dominant inheritance (HP:0001423)2.83463070
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83032924
42Respiratory difficulties (HP:0002880)2.63237424
43Parakeratosis (HP:0001036)2.52229844
44Pancreatic cysts (HP:0001737)2.50347719
45Sensory axonal neuropathy (HP:0003390)2.45579531
46Lethargy (HP:0001254)2.39951240
47Abnormality of urine glucose concentration (HP:0011016)2.39467167
48Glycosuria (HP:0003076)2.39467167
49Hyperphosphaturia (HP:0003109)2.35780789
50Molar tooth sign on MRI (HP:0002419)2.35327090
51Abnormality of midbrain morphology (HP:0002418)2.35327090
52CNS demyelination (HP:0007305)2.33213714
53Pancreatic fibrosis (HP:0100732)2.31151904
54True hermaphroditism (HP:0010459)2.30476286
55Pallor (HP:0000980)2.27381183
56Generalized aminoaciduria (HP:0002909)2.25199790
57Cerebral hemorrhage (HP:0001342)2.20681422
58Emotional lability (HP:0000712)2.20116669
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.19992689
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19992689
61Abnormality of the calf musculature (HP:0001430)2.17422854
62Abnormal urine phosphate concentration (HP:0012599)2.10601967
63Muscle fiber splitting (HP:0003555)2.08349420
64Type I transferrin isoform profile (HP:0003642)2.07411749
65Myotonia (HP:0002486)2.06786221
66Methylmalonic acidemia (HP:0002912)2.05669444
67Neurofibrillary tangles (HP:0002185)2.05662445
68Palpitations (HP:0001962)2.05414248
69Exercise-induced myalgia (HP:0003738)2.02044617
70Abnormality of cells of the erythroid lineage (HP:0012130)2.01993727
71Abnormal pupillary function (HP:0007686)1.98797457
72Sclerocornea (HP:0000647)1.97097196
73Atonic seizures (HP:0010819)1.96715193
74Gait imbalance (HP:0002141)1.95999698
75Syncope (HP:0001279)1.95371202
76Septo-optic dysplasia (HP:0100842)1.94770124
77Methylmalonic aciduria (HP:0012120)1.93566596
78Abnormal ciliary motility (HP:0012262)1.93036597
79Hyperventilation (HP:0002883)1.92263476
80Congenital ichthyosiform erythroderma (HP:0007431)1.92192827
81Progressive external ophthalmoplegia (HP:0000590)1.89480493
82Nephronophthisis (HP:0000090)1.88954891
83Absent septum pellucidum (HP:0001331)1.87729175
84Cerebral inclusion bodies (HP:0100314)1.87072479
85Vomiting (HP:0002013)1.86650126
86Macrocytic anemia (HP:0001972)1.86282169
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83748161
88Conjunctival hamartoma (HP:0100780)1.83638086
89Congenital primary aphakia (HP:0007707)1.83199364
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82139934
91Hypothermia (HP:0002045)1.80977233
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.80903425
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80716492
94Anxiety (HP:0000739)1.78028000
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75606246
96Dicarboxylic aciduria (HP:0003215)1.75606246
97Absence seizures (HP:0002121)1.75246736
98Prolonged QT interval (HP:0001657)1.73813277
99Male pseudohermaphroditism (HP:0000037)1.73529387
100Ventricular tachycardia (HP:0004756)1.73305609
101Retinal dysplasia (HP:0007973)1.72314275
102Renal tubular dysfunction (HP:0000124)1.72098341
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72058900
104Abnormality of alanine metabolism (HP:0010916)1.72058900
105Hyperalaninemia (HP:0003348)1.72058900
106Hypoplastic left heart (HP:0004383)1.71109208
107Nephrogenic diabetes insipidus (HP:0009806)1.71006320
108Limb dystonia (HP:0002451)1.70799254
109Absent thumb (HP:0009777)1.70097392
110Dialeptic seizures (HP:0011146)1.69931136
111Muscle stiffness (HP:0003552)1.69292031
112Poor suck (HP:0002033)1.68493969
113Degeneration of anterior horn cells (HP:0002398)1.66156059
114Abnormality of the anterior horn cell (HP:0006802)1.66156059
115Atrial fibrillation (HP:0005110)1.65574012
116Abnormality of placental membranes (HP:0011409)1.64774704
117Amniotic constriction ring (HP:0009775)1.64774704
118Medial flaring of the eyebrow (HP:0010747)1.64425825
119Hyperglycinemia (HP:0002154)1.64193012
120Congenital stationary night blindness (HP:0007642)1.63875364
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.63715791
122Abnormal protein N-linked glycosylation (HP:0012347)1.63715791
123Abnormal protein glycosylation (HP:0012346)1.63715791
124Abnormal glycosylation (HP:0012345)1.63715791
125Abnormal respiratory epithelium morphology (HP:0012253)1.63366798
126Abnormal respiratory motile cilium morphology (HP:0005938)1.63366798
127Focal seizures (HP:0007359)1.62984291
128Delusions (HP:0000746)1.62765261
129Genital tract atresia (HP:0001827)1.62482340
130Vaginal atresia (HP:0000148)1.62211039
131Blindness (HP:0000618)1.62192323
132Pendular nystagmus (HP:0012043)1.61981274
133Abnormal respiratory motile cilium physiology (HP:0012261)1.61586019
134Hyperglycinuria (HP:0003108)1.61180791
135Stenosis of the external auditory canal (HP:0000402)1.61098295
136Supraventricular tachycardia (HP:0004755)1.60237047
137Abnormal number of erythroid precursors (HP:0012131)1.60191277
138Primary atrial arrhythmia (HP:0001692)1.60073537
139Gliosis (HP:0002171)1.59216143
140Aplastic anemia (HP:0001915)1.58830971
141Oral leukoplakia (HP:0002745)1.58019602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.36488139
2STK393.62490803
3NME13.22575845
4PNCK3.03729417
5MAP3K122.65779804
6OXSR12.65701751
7MYLK2.53235578
8WNK42.47656571
9CASK2.35798250
10NME22.30062657
11GRK52.13863277
12EPHA42.11061217
13GRK72.09772390
14ZAK2.07849951
15ARAF2.07542748
16MST41.97650434
17PBK1.85240275
18OBSCN1.76441401
19MUSK1.74678372
20BUB11.68497818
21BCR1.61734014
22STK161.57770854
23NTRK31.57443688
24CDK191.53817284
25LIMK11.53792303
26PHKG11.53221336
27PHKG21.53221336
28WEE11.49964890
29MAP2K71.48350813
30MARK11.48297212
31CAMK2D1.47386556
32MAP3K41.44370282
33CAMK2B1.42428870
34TRIM281.41006557
35NEK11.40441578
36FGR1.39618707
37CAMK2A1.38133623
38PDK41.37638270
39PDK31.37638270
40TNIK1.37623312
41MAPKAPK51.36792946
42SRPK11.36606428
43GRK11.32193690
44NUAK11.29981999
45SCYL21.29646559
46PKN11.28388645
47LMTK21.25814890
48RIPK41.23927755
49TAF11.19424733
50UHMK11.18843104
51MAP4K21.18791700
52PLK21.14223602
53TLK11.09947703
54INSRR1.09385904
55TESK11.09132816
56CDC71.08251578
57EIF2AK31.07825313
58CAMK2G1.07515481
59ADRBK21.05973974
60ROCK21.05283421
61MINK11.01637106
62BMPR1B1.00314639
63PTK2B0.99860093
64MAP2K40.99801955
65DYRK30.98471178
66BMPR20.97150631
67DAPK30.96483067
68ADRBK10.96184422
69BCKDK0.96013400
70MAPK130.92764561
71PDK20.91145940
72CSNK1G30.89586549
73WNK30.89255776
74PRKCE0.89003428
75PIK3CA0.87573116
76RPS6KB20.85081871
77PRKCI0.84636895
78ABL20.84048225
79VRK10.81335578
80PAK30.80965349
81MAPKAPK30.78797792
82PLK30.78557105
83NTRK10.75885122
84PINK10.75608528
85FES0.73631170
86DYRK20.73433542
87PRKACA0.71671719
88AURKA0.70393800
89CDK50.68382692
90WNK10.67906687
91BRSK20.66886370
92CSNK1G20.66582570
93NTRK20.66496672
94PLK10.66164472
95AURKB0.66125745
96CDK140.65927259
97CSNK2A20.65275668
98ERBB30.64749675
99PRKCG0.61911254
100TTN0.60736571
101TAOK30.60233180
102ILK0.59964277
103BRAF0.59590094
104MAP3K90.58821478
105CCNB10.57981436
106CSNK2A10.55533900
107MAPK150.55497764
108CDK80.54334815
109BRSK10.54130069
110CDK150.51157443
111MAPK120.50163437
112CDK180.49334065
113CSNK1E0.49321945
114CSNK1G10.48369093
115EIF2AK20.47795649
116RPS6KA50.47755958
117PLK40.47646176
118PIM20.47639931
119CDK11A0.47195917
120MST1R0.46785131
121GRK60.44933205
122PRKCQ0.44543643
123DAPK10.44297477
124CHEK20.43639184
125TSSK60.43429455
126TESK20.42640471
127CSNK1A10.42384897
128ROCK10.41311759
129PRKG10.40487715
130DAPK20.40280557
131IRAK20.39749353
132PRKD10.36710582
133PRKACB0.36170411
134CSNK1A1L0.34595347
135DYRK1A0.34318476
136PAK60.34148298
137PRKCA0.33947910
138MOS0.32268702
139CAMK10.32102599
140KSR20.28591730
141EIF2AK10.28455759

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.72348363
2Parkinsons disease_Homo sapiens_hsa050125.70165207
3Alzheimers disease_Homo sapiens_hsa050104.50930732
4Huntingtons disease_Homo sapiens_hsa050163.97356262
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.57939419
6* Cardiac muscle contraction_Homo sapiens_hsa042603.42249220
7Ribosome_Homo sapiens_hsa030102.78707171
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46259647
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11124374
10Fatty acid elongation_Homo sapiens_hsa000622.05024231
11Collecting duct acid secretion_Homo sapiens_hsa049661.96737700
12Homologous recombination_Homo sapiens_hsa034401.79092776
13Proteasome_Homo sapiens_hsa030501.79050288
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76534868
15Protein export_Homo sapiens_hsa030601.68139582
16Propanoate metabolism_Homo sapiens_hsa006401.63335159
17Nicotine addiction_Homo sapiens_hsa050331.62829826
18Sulfur metabolism_Homo sapiens_hsa009201.50514144
19Folate biosynthesis_Homo sapiens_hsa007901.48931610
20Mismatch repair_Homo sapiens_hsa034301.43801949
21Pyruvate metabolism_Homo sapiens_hsa006201.42240511
22Butanoate metabolism_Homo sapiens_hsa006501.39504994
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18240680
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17979434
25Spliceosome_Homo sapiens_hsa030401.16924434
26Basal transcription factors_Homo sapiens_hsa030221.15466243
27Vibrio cholerae infection_Homo sapiens_hsa051101.12483891
28DNA replication_Homo sapiens_hsa030301.10493644
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09814342
30RNA degradation_Homo sapiens_hsa030181.08506625
31RNA polymerase_Homo sapiens_hsa030201.08041551
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07505026
33Nucleotide excision repair_Homo sapiens_hsa034201.07189212
34Synaptic vesicle cycle_Homo sapiens_hsa047211.06380310
35Serotonergic synapse_Homo sapiens_hsa047261.01464205
36GABAergic synapse_Homo sapiens_hsa047271.01176819
37Sulfur relay system_Homo sapiens_hsa041220.97892221
38Fanconi anemia pathway_Homo sapiens_hsa034600.92798700
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92142441
40Taste transduction_Homo sapiens_hsa047420.91733502
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91491269
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87216983
43Carbon metabolism_Homo sapiens_hsa012000.83612542
44Glutamatergic synapse_Homo sapiens_hsa047240.81627568
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81469565
46Ether lipid metabolism_Homo sapiens_hsa005650.80911506
47Morphine addiction_Homo sapiens_hsa050320.80575027
48* Metabolic pathways_Homo sapiens_hsa011000.79874454
49Phototransduction_Homo sapiens_hsa047440.79259072
50Nitrogen metabolism_Homo sapiens_hsa009100.78413988
51Steroid biosynthesis_Homo sapiens_hsa001000.78229813
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77142476
53Caffeine metabolism_Homo sapiens_hsa002320.74188642
54Tyrosine metabolism_Homo sapiens_hsa003500.72773730
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.72139925
56Circadian entrainment_Homo sapiens_hsa047130.71944933
57Renin secretion_Homo sapiens_hsa049240.71358329
58RNA transport_Homo sapiens_hsa030130.70816002
59Amphetamine addiction_Homo sapiens_hsa050310.67305402
60Fatty acid metabolism_Homo sapiens_hsa012120.66603996
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65621236
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.65467513
63Calcium signaling pathway_Homo sapiens_hsa040200.64652066
64Salivary secretion_Homo sapiens_hsa049700.64416642
65Dilated cardiomyopathy_Homo sapiens_hsa054140.63553685
66Phenylalanine metabolism_Homo sapiens_hsa003600.62786368
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62719439
68Dopaminergic synapse_Homo sapiens_hsa047280.62254314
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61982831
70Fatty acid degradation_Homo sapiens_hsa000710.61900569
71Gastric acid secretion_Homo sapiens_hsa049710.61582216
72Base excision repair_Homo sapiens_hsa034100.60031940
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59979131
74Long-term depression_Homo sapiens_hsa047300.58780639
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58106319
76Glutathione metabolism_Homo sapiens_hsa004800.57774606
77Linoleic acid metabolism_Homo sapiens_hsa005910.56463400
78Long-term potentiation_Homo sapiens_hsa047200.56205215
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56182775
80One carbon pool by folate_Homo sapiens_hsa006700.55002290
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54995704
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54778607
83Peroxisome_Homo sapiens_hsa041460.54711735
84Rheumatoid arthritis_Homo sapiens_hsa053230.52788819
85Arginine and proline metabolism_Homo sapiens_hsa003300.51664893
86Histidine metabolism_Homo sapiens_hsa003400.51489643
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49674321
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47706554
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.47690945
90Retinol metabolism_Homo sapiens_hsa008300.45869990
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45745202
92Regulation of autophagy_Homo sapiens_hsa041400.44495143
93Cholinergic synapse_Homo sapiens_hsa047250.44165882
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41975451
95Cocaine addiction_Homo sapiens_hsa050300.41776073
96Olfactory transduction_Homo sapiens_hsa047400.40766109
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39472135
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.39073428
99Arachidonic acid metabolism_Homo sapiens_hsa005900.38136496
100Oxytocin signaling pathway_Homo sapiens_hsa049210.37963583
101Vitamin digestion and absorption_Homo sapiens_hsa049770.37730462
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34930858
103Alcoholism_Homo sapiens_hsa050340.33960473
104Insulin secretion_Homo sapiens_hsa049110.32505910
105Chemical carcinogenesis_Homo sapiens_hsa052040.32368638
106beta-Alanine metabolism_Homo sapiens_hsa004100.31932842
107Systemic lupus erythematosus_Homo sapiens_hsa053220.31400874
108Axon guidance_Homo sapiens_hsa043600.31313065
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30907646
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.30839760
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30142142
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29999039
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28366341
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28163884
115Sphingolipid metabolism_Homo sapiens_hsa006000.27669466
116Fat digestion and absorption_Homo sapiens_hsa049750.26723477
117Pancreatic secretion_Homo sapiens_hsa049720.26580148
118Gap junction_Homo sapiens_hsa045400.26090025
119N-Glycan biosynthesis_Homo sapiens_hsa005100.25899916
120Mineral absorption_Homo sapiens_hsa049780.25743465
121Selenocompound metabolism_Homo sapiens_hsa004500.25176585
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25146244
123Oocyte meiosis_Homo sapiens_hsa041140.24952478
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23959524
125Vitamin B6 metabolism_Homo sapiens_hsa007500.23208516
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22278639
127Phagosome_Homo sapiens_hsa041450.22147642
128Purine metabolism_Homo sapiens_hsa002300.21837698
129PPAR signaling pathway_Homo sapiens_hsa033200.21280305
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21190431
131Pyrimidine metabolism_Homo sapiens_hsa002400.19392645
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17753164
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17699379
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17385568
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.17294018
136Tryptophan metabolism_Homo sapiens_hsa003800.17154467
137GnRH signaling pathway_Homo sapiens_hsa049120.14119051

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