COX7A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.94268827
2cardiac myofibril assembly (GO:0055003)8.21679851
3myofibril assembly (GO:0030239)7.46743993
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.42003348
5tricarboxylic acid cycle (GO:0006099)7.15206336
6actin-myosin filament sliding (GO:0033275)6.83827688
7muscle filament sliding (GO:0030049)6.83827688
8negative regulation of potassium ion transmembrane transport (GO:1901380)6.64837072
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.51024610
10cardiac muscle contraction (GO:0060048)6.50244921
11skeletal muscle adaptation (GO:0043501)6.49702698
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.29780502
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.17268296
14regulation of relaxation of muscle (GO:1901077)6.13802060
15cardiac muscle cell development (GO:0055013)6.09378397
16plasma membrane repair (GO:0001778)5.91874065
17regulation of actin filament-based movement (GO:1903115)5.91509265
18regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.86681001
19regulation of skeletal muscle contraction (GO:0014819)5.85356385
20carnitine shuttle (GO:0006853)5.71848112
21cardiac cell development (GO:0055006)5.71111896
22striated muscle atrophy (GO:0014891)5.67831715
23actin-mediated cell contraction (GO:0070252)5.63741410
24actomyosin structure organization (GO:0031032)5.56937860
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.56033353
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.49445395
27cardiac muscle tissue morphogenesis (GO:0055008)5.45692770
28bundle of His cell to Purkinje myocyte communication (GO:0086069)5.44518843
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.44499543
30adult heart development (GO:0007512)5.40434842
31ventricular cardiac muscle cell action potential (GO:0086005)5.39604897
32regulation of acyl-CoA biosynthetic process (GO:0050812)5.34372054
33ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.29332001
34heart contraction (GO:0060047)5.28778641
35heart process (GO:0003015)5.28778641
36respiratory electron transport chain (GO:0022904)5.25061108
37striated muscle contraction (GO:0006941)5.18924995
38energy coupled proton transport, down electrochemical gradient (GO:0015985)5.15947800
39ATP synthesis coupled proton transport (GO:0015986)5.15947800
40regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.11982007
41muscle atrophy (GO:0014889)5.10691737
42regulation of cell communication by electrical coupling (GO:0010649)5.10262173
43cardiac muscle hypertrophy (GO:0003300)5.10097323
44electron transport chain (GO:0022900)5.09818497
45sarcoplasmic reticulum calcium ion transport (GO:0070296)5.05667788
46heart trabecula formation (GO:0060347)4.97014582
47oxidative phosphorylation (GO:0006119)4.96515054
48regulation of sarcomere organization (GO:0060297)4.94899061
49fatty acid transmembrane transport (GO:1902001)4.94765838
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.92784376
51muscle tissue morphogenesis (GO:0060415)4.91615410
52regulation of coenzyme metabolic process (GO:0051196)4.89081267
53regulation of cofactor metabolic process (GO:0051193)4.89081267
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.89070449
55regulation of sequestering of triglyceride (GO:0010889)4.86288443
56striated muscle hypertrophy (GO:0014897)4.85199318
57regulation of striated muscle contraction (GO:0006942)4.73295250
58NADH metabolic process (GO:0006734)4.68156624
59response to muscle activity (GO:0014850)4.63971940
60muscle system process (GO:0003012)4.63449814
61regulation of the force of heart contraction (GO:0002026)4.46267444
62response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.37266394
63detection of calcium ion (GO:0005513)4.29600768
64muscle hypertrophy (GO:0014896)4.29582036
65regulation of membrane repolarization (GO:0060306)4.28739057
66response to inactivity (GO:0014854)4.26567758
67striated muscle adaptation (GO:0014888)4.24103419
68carnitine transmembrane transport (GO:1902603)4.24063415
69cell communication involved in cardiac conduction (GO:0086065)4.21904212
70actin filament-based movement (GO:0030048)4.21522586
71muscle fiber development (GO:0048747)4.15228312
72creatine metabolic process (GO:0006600)4.13624173
73regulation of cardiac muscle cell contraction (GO:0086004)4.10928694
74cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.10449692
752-oxoglutarate metabolic process (GO:0006103)4.05651633
76regulation of sulfur metabolic process (GO:0042762)3.93082166
77regulation of cardiac muscle contraction (GO:0055117)3.90743715
78carnitine transport (GO:0015879)3.87731650
79amino-acid betaine transport (GO:0015838)3.87731650
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.84688149
81fatty acid beta-oxidation (GO:0006635)3.84065966
82response to epinephrine (GO:0071871)3.77193171
83regulation of fatty acid oxidation (GO:0046320)3.77053589
84regulation of ATPase activity (GO:0043462)3.76211157
85regulation of ATP catabolic process (GO:1903289)3.76211157
86cellular response to epinephrine stimulus (GO:0071872)3.75943509
87regulation of heart rate (GO:0002027)3.75635683
88cardiac muscle cell action potential involved in contraction (GO:0086002)3.74058413
89negative regulation of potassium ion transport (GO:0043267)3.70863547
90cardiac muscle cell action potential (GO:0086001)3.68488592
91skeletal muscle contraction (GO:0003009)3.64945052
92regulation of muscle contraction (GO:0006937)3.64613579
93succinate metabolic process (GO:0006105)3.64289353
94skeletal muscle fiber development (GO:0048741)3.64258685
95cardiac muscle adaptation (GO:0014887)3.62627697
96cardiac muscle hypertrophy in response to stress (GO:0014898)3.62627697
97muscle hypertrophy in response to stress (GO:0003299)3.62627697
98negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.61974844
99negative regulation of protein localization to cell surface (GO:2000009)3.59890618
100glycogen catabolic process (GO:0005980)3.56294005
101ATP biosynthetic process (GO:0006754)3.53794379
102oxygen transport (GO:0015671)3.52118681
103regulation of heart contraction (GO:0008016)3.51641348
104relaxation of cardiac muscle (GO:0055119)3.51420777
105muscle adaptation (GO:0043500)3.50195679
106ubiquinone biosynthetic process (GO:0006744)3.49270937
107quinone biosynthetic process (GO:1901663)3.49270937
108positive regulation of ATPase activity (GO:0032781)3.48680825
109positive regulation of ATP catabolic process (GO:1903291)3.48680825
110positive regulation of heart rate (GO:0010460)3.48381941
111striated muscle cell development (GO:0055002)3.47704219
112cell communication by electrical coupling (GO:0010644)3.47306096
113regulation of muscle system process (GO:0090257)3.46221606
114muscle contraction (GO:0006936)3.45415670
115regulation of calcium ion transmembrane transport (GO:1903169)3.45093777
116regulation of calcium ion transmembrane transporter activity (GO:1901019)3.45093777
117negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.44686164
118negative regulation of calcium ion transmembrane transport (GO:1903170)3.44686164
119negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.43854277
120regulation of cardioblast differentiation (GO:0051890)3.43227367
121ventricular cardiac muscle cell development (GO:0055015)3.41203364
122positive regulation of cation channel activity (GO:2001259)3.39780957
123positive regulation of heart contraction (GO:0045823)3.38348992
124negative regulation of striated muscle cell apoptotic process (GO:0010664)3.37158514
125myotube cell development (GO:0014904)3.35035044
126positive regulation of potassium ion transmembrane transport (GO:1901381)3.33372238
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32612410
128glucan catabolic process (GO:0009251)3.32086597
129skeletal muscle tissue development (GO:0007519)3.26246599
130positive regulation of ion transmembrane transporter activity (GO:0032414)3.26223393
131glycogen biosynthetic process (GO:0005978)3.14739612
132glucan biosynthetic process (GO:0009250)3.14739612
133response to caffeine (GO:0031000)3.14405580
134cellular polysaccharide catabolic process (GO:0044247)3.12540086
135calcium-mediated signaling using intracellular calcium source (GO:0035584)3.08281808
136positive regulation of potassium ion transport (GO:0043268)3.04197688
137regulation of potassium ion transmembrane transporter activity (GO:1901016)2.98940063
138negative regulation of ion transmembrane transporter activity (GO:0032413)2.91873301
139response to redox state (GO:0051775)2.91294326
140gluconeogenesis (GO:0006094)2.88114432
141muscle cell cellular homeostasis (GO:0046716)2.81392029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.64407806
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.17493635
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.93818625
4EP300_21415370_ChIP-Seq_HL-1_Mouse4.45071607
5TBX20_22080862_ChIP-Seq_HEART_Mouse3.97194324
6TBX20_22328084_ChIP-Seq_HEART_Mouse3.97194324
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.72452937
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.56686815
9ZNF263_19887448_ChIP-Seq_K562_Human3.50459071
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26215057
11RARG_19884340_ChIP-ChIP_MEFs_Mouse3.09457185
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.93631464
13MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.80575587
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.69570155
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.57076857
16* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.32683888
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.21595164
18PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.11689818
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.04383976
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02795634
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91551970
22CLOCK_20551151_ChIP-Seq_293T_Human1.82151615
23NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.80594892
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80382276
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73503788
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66304408
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65990710
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63457165
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63210109
30HTT_18923047_ChIP-ChIP_STHdh_Human1.62249445
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57616254
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50701610
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49251281
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.48658021
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48549462
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47526137
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44397713
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.43291961
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36646805
40IGF1R_20145208_ChIP-Seq_DFB_Human1.36365567
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35398357
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35243129
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35092731
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32994758
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32561165
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.30347219
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28011594
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27163644
49CTCF_27219007_Chip-Seq_Bcells_Human1.26231838
50EZH2_22144423_ChIP-Seq_EOC_Human1.23955817
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20599311
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.20531661
53TP63_22573176_ChIP-Seq_HFKS_Human1.17776605
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17090633
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.16179171
56ATF3_27146783_Chip-Seq_COLON_Human1.15526054
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14326097
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13720809
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13346777
60RACK7_27058665_Chip-Seq_MCF-7_Human1.10362869
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09134322
62LXR_22292898_ChIP-Seq_THP-1_Human1.08593929
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08063028
64GBX2_23144817_ChIP-Seq_PC3_Human1.07790279
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.07645165
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03997010
67P68_20966046_ChIP-Seq_HELA_Human1.03850733
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02291976
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.01457355
70* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00568964
71EZH2_27294783_Chip-Seq_NPCs_Mouse0.99789784
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99170472
73SPI1_20517297_ChIP-Seq_HL60_Human0.99143711
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99073811
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98920807
76PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98832219
77RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98309330
78EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98309330
79SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97986906
80GATA1_19941826_ChIP-Seq_K562_Human0.96923886
81KDM2B_26808549_Chip-Seq_DND41_Human0.96624587
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96613737
83RUNX1_27514584_Chip-Seq_MCF-7_Human0.96328081
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95629343
85SOX2_21211035_ChIP-Seq_LN229_Gbm0.94426907
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.93994701
87BCL6_27268052_Chip-Seq_Bcells_Human0.93763979
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93333728
89BCOR_27268052_Chip-Seq_Bcells_Human0.93280038
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92595022
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.91077135
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90232666
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89530538
94OCT4_20526341_ChIP-Seq_ESCs_Human0.88941333
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88931663
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.88679566
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88349234
98ISL1_27105846_Chip-Seq_CPCs_Mouse0.88002325
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.87813625
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87373963
101VDR_22108803_ChIP-Seq_LS180_Human0.87356441
102GATA1_22025678_ChIP-Seq_K562_Human0.86658380
103YY1_22570637_ChIP-Seq_MALME-3M_Human0.86244369
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86211026
105WT1_19549856_ChIP-ChIP_CCG9911_Human0.85416708
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84877286
107GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83283674
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82650736
109CRX_20693478_ChIP-Seq_RETINA_Mouse0.82246517
110NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82128403
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82128403
112JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81081106
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81067471
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80929728
115FOXH1_21741376_ChIP-Seq_ESCs_Human0.80860851
116CBX2_27304074_Chip-Seq_ESCs_Mouse0.80802365
117CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80800274
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80281552
119HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80257361
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80052645
121CTCF_21964334_Chip-Seq_Bcells_Human0.79438028
122DROSHA_22980978_ChIP-Seq_HELA_Human0.79371191
123SA1_27219007_Chip-Seq_Bcells_Human0.79083945
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78804094
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78424624
126E2F1_20622854_ChIP-Seq_HELA_Human0.78278182
127FLI1_27457419_Chip-Seq_LIVER_Mouse0.76823504
128ZNF274_21170338_ChIP-Seq_K562_Hela0.76297634
129GATA2_19941826_ChIP-Seq_K562_Human0.76281145
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.76215120
131PHF8_20622853_ChIP-Seq_HELA_Human0.75561674
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75104543
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74687829
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.74475732
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.74458082
136HNFA_21074721_ChIP-Seq_CACO-2_Human0.73945962
137TET1_21490601_ChIP-Seq_MESCs_Mouse0.73606168
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.73311154
139SMAD4_21799915_ChIP-Seq_A2780_Human0.73220957
140* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72747215
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.72608364
142CJUN_26792858_Chip-Seq_BT549_Human0.72601975
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72169949
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71946148
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.71528173
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.71227065
147* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.71002855
148CBX2_22325352_ChIP-Seq_293T-Rex_Human0.70777760
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.69290561
150CREB1_26743006_Chip-Seq_LNCaP_Human0.68110433
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.67994946
152GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67608706
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.67295983
154* GATA1_19941827_ChIP-Seq_MEL_Mouse0.67133062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.86475630
2MP0003646_muscle_fatigue6.25905526
3MP0004084_abnormal_cardiac_muscle5.49793221
4MP0000751_myopathy5.06591817
5MP0004215_abnormal_myocardial_fiber4.58624947
6MP0004036_abnormal_muscle_relaxation4.20572859
7MP0000749_muscle_degeneration3.95420323
8MP0005330_cardiomyopathy3.88982524
9MP0002972_abnormal_cardiac_muscle3.09152053
10MP0004087_abnormal_muscle_fiber3.08842114
11MP0004130_abnormal_muscle_cell2.80967354
12MP0000750_abnormal_muscle_regeneration2.80369388
13MP0003137_abnormal_impulse_conducting2.79997920
14MP0008775_abnormal_heart_ventricle2.79731726
15MP0005620_abnormal_muscle_contractility2.66070323
16MP0005385_cardiovascular_system_phenoty2.61354650
17MP0001544_abnormal_cardiovascular_syste2.61354650
18MP0004484_altered_response_of2.55719506
19MP0002106_abnormal_muscle_physiology2.54542344
20MP0010630_abnormal_cardiac_muscle2.53084227
21MP0006138_congestive_heart_failure2.45607022
22MP0002269_muscular_atrophy2.34928549
23MP0004145_abnormal_muscle_electrophysio2.22087973
24MP0003828_pulmonary_edema2.19457184
25MP0006036_abnormal_mitochondrial_physio2.10539647
26MP0005369_muscle_phenotype2.05035238
27MP0000759_abnormal_skeletal_muscle2.02150833
28MP0003221_abnormal_cardiomyocyte_apopto2.00009658
29MP0004085_abnormal_heartbeat1.99791559
30MP0000747_muscle_weakness1.98111756
31MP0005666_abnormal_adipose_tissue1.80093981
32MP0004233_abnormal_muscle_weight1.77073685
33MP0005670_abnormal_white_adipose1.73299641
34MP0002332_abnormal_exercise_endurance1.61269113
35MP0004510_myositis1.60782188
36MP0002127_abnormal_cardiovascular_syste1.52988130
37MP0003950_abnormal_plasma_membrane1.49871159
38MP0004185_abnormal_adipocyte_glucose1.35896361
39MP0000343_altered_response_to1.26815488
40MP0003567_abnormal_fetal_cardiomyocyte1.16565400
41MP0002234_abnormal_pharynx_morphology1.16269567
42MP0006035_abnormal_mitochondrial_morpho1.16157535
43MP0005375_adipose_tissue_phenotype1.15689818
44MP0009780_abnormal_chondrocyte_physiolo1.07929232
45MP0000266_abnormal_heart_morphology1.07770679
46MP0005165_increased_susceptibility_to1.07240784
47MP0005266_abnormal_metabolism1.00546582
48MP0003806_abnormal_nucleotide_metabolis0.94325737
49MP0003279_aneurysm0.92950088
50MP0004270_analgesia0.91748179
51MP0008004_abnormal_stomach_pH0.91061203
52MP0004043_abnormal_pH_regulation0.88492008
53MP0010368_abnormal_lymphatic_system0.86801953
54MP0000230_abnormal_systemic_arterial0.85407144
55MP0002108_abnormal_muscle_morphology0.82231604
56MP0002971_abnormal_brown_adipose0.80477244
57MP0001661_extended_life_span0.71361929
58MP0002909_abnormal_adrenal_gland0.70130845
59MP0002128_abnormal_blood_circulation0.69886612
60MP0002822_catalepsy0.64839884
61MP0003566_abnormal_cell_adhesion0.63209817
62MP0000003_abnormal_adipose_tissue0.62582468
63MP0005451_abnormal_body_composition0.59748419
64MP0005319_abnormal_enzyme/_coenzyme0.59723664
65MP0004147_increased_porphyrin_level0.59476684
66MP0001879_abnormal_lymphatic_vessel0.59166055
67MP0003705_abnormal_hypodermis_morpholog0.58918143
68MP0002078_abnormal_glucose_homeostasis0.55736190
69MP0000733_abnormal_muscle_development0.53759263
70MP0005623_abnormal_meninges_morphology0.53266513
71MP0005535_abnormal_body_temperature0.52791429
72MP0000013_abnormal_adipose_tissue0.52381648
73MP0000767_abnormal_smooth_muscle0.47349764
74MP0008569_lethality_at_weaning0.45223532
75MP0003879_abnormal_hair_cell0.44175534
76MP0005503_abnormal_tendon_morphology0.43987773
77MP0005187_abnormal_penis_morphology0.42791190
78MP0005334_abnormal_fat_pad0.41423520
79MP0009840_abnormal_foam_cell0.40471690
80MP0008961_abnormal_basal_metabolism0.40203529
81MP0002118_abnormal_lipid_homeostasis0.39082122
82MP0001299_abnormal_eye_distance/0.38590022
83MP0003984_embryonic_growth_retardation0.37546790
84MP0001984_abnormal_olfaction0.36451307
85MP0002088_abnormal_embryonic_growth/wei0.36100371
86MP0002254_reproductive_system_inflammat0.35873404
87MP0002925_abnormal_cardiovascular_devel0.34724662
88MP0005584_abnormal_enzyme/coenzyme_acti0.34603693
89MP0003045_fibrosis0.34320306
90MP0009115_abnormal_fat_cell0.33705152
91MP0005386_behavior/neurological_phenoty0.33042213
92MP0004924_abnormal_behavior0.33042213
93MP0005167_abnormal_blood-brain_barrier0.32786249
94MP0003195_calcinosis0.32644415
95MP0003948_abnormal_gas_homeostasis0.32311574
96MP0001958_emphysema0.32305534
97MP0005332_abnormal_amino_acid0.31157938
98MP0005083_abnormal_biliary_tract0.31060097
99MP0005166_decreased_susceptibility_to0.30910987
100MP0004272_abnormal_basement_membrane0.30030516
101MP0008438_abnormal_cutaneous_collagen0.29949631
102MP0005275_abnormal_skin_tensile0.29243118
103MP0002638_abnormal_pupillary_reflex0.29139831
104MP0001727_abnormal_embryo_implantation0.28530648
105MP0001614_abnormal_blood_vessel0.28402906
106MP0005376_homeostasis/metabolism_phenot0.27078442
107MP0009384_cardiac_valve_regurgitation0.26858950
108MP0001784_abnormal_fluid_regulation0.26811050
109MP0002970_abnormal_white_adipose0.26761526
110MP0001853_heart_inflammation0.26291044
111MP0002876_abnormal_thyroid_physiology0.24050722
112MP0002896_abnormal_bone_mineralization0.24013928
113MP0002272_abnormal_nervous_system0.22701230
114MP0000249_abnormal_blood_vessel0.22469324
115MP0005452_abnormal_adipose_tissue0.22236826
116MP0005595_abnormal_vascular_smooth0.21276318
117MP0003011_delayed_dark_adaptation0.21243565
118MP0001440_abnormal_grooming_behavior0.21204466
119MP0009643_abnormal_urine_homeostasis0.21087169
120MP0001501_abnormal_sleep_pattern0.20857084
121MP0003959_abnormal_lean_body0.20307438
122MP0002066_abnormal_motor_capabilities/c0.19957324
123MP0008874_decreased_physiological_sensi0.19907148
124MP0004134_abnormal_chest_morphology0.19446533

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)8.24557324
2Sudden death (HP:0001699)7.38615028
3Ventricular tachycardia (HP:0004756)6.81565239
4Calf muscle hypertrophy (HP:0008981)6.43264002
5Exercise-induced myalgia (HP:0003738)6.00132157
6Muscle hypertrophy of the lower extremities (HP:0008968)5.97040547
7Exercise-induced muscle cramps (HP:0003710)5.86423418
8Atrial fibrillation (HP:0005110)5.66463106
9Muscle fiber splitting (HP:0003555)5.42162350
10Primary atrial arrhythmia (HP:0001692)5.30102899
11Myoglobinuria (HP:0002913)5.20591324
12Supraventricular tachycardia (HP:0004755)5.13487093
13Lipoatrophy (HP:0100578)5.05373523
14Abnormality of the calf musculature (HP:0001430)5.04052898
15Supraventricular arrhythmia (HP:0005115)5.02244363
16Hyporeflexia of lower limbs (HP:0002600)4.84235311
17Subaortic stenosis (HP:0001682)4.68282670
18Abnormality of the left ventricular outflow tract (HP:0011103)4.68282670
19Right ventricular cardiomyopathy (HP:0011663)4.65683924
20Bundle branch block (HP:0011710)4.59522218
21Palpitations (HP:0001962)4.47863970
22Distal arthrogryposis (HP:0005684)4.37643181
23Round ear (HP:0100830)4.31267791
24Myopathic facies (HP:0002058)4.30365700
25Syncope (HP:0001279)4.30022503
26Dilated cardiomyopathy (HP:0001644)4.26775585
27Rhabdomyolysis (HP:0003201)4.12034655
28Frequent falls (HP:0002359)4.00458767
29EMG: myopathic abnormalities (HP:0003458)3.99200536
30Asymmetric septal hypertrophy (HP:0001670)3.98026540
31Prolonged QT interval (HP:0001657)3.92957736
32Acute necrotizing encephalopathy (HP:0006965)3.86359454
33Abnormal mitochondria in muscle tissue (HP:0008316)3.82484855
34Hepatic necrosis (HP:0002605)3.80802994
35Increased connective tissue (HP:0009025)3.80672177
36Centrally nucleated skeletal muscle fibers (HP:0003687)3.79415861
37Heart block (HP:0012722)3.77823069
38Ventricular arrhythmia (HP:0004308)3.66849096
39Difficulty running (HP:0009046)3.64894608
40Ulnar deviation of the wrist (HP:0003049)3.58016951
41Abnormal atrioventricular conduction (HP:0005150)3.56390720
42Atrioventricular block (HP:0001678)3.54583420
43Acute encephalopathy (HP:0006846)3.38280222
44Myotonia (HP:0002486)3.37438017
45Hepatocellular necrosis (HP:0001404)3.37430316
46Progressive macrocephaly (HP:0004481)3.20453091
47Mitochondrial inheritance (HP:0001427)3.19656026
48Ventricular fibrillation (HP:0001663)3.19027678
49Cerebral edema (HP:0002181)3.00844307
50Hypoglycemic coma (HP:0001325)3.00264212
51Dicarboxylic aciduria (HP:0003215)2.98845989
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.98845989
53Increased CSF lactate (HP:0002490)2.96936189
54Increased muscle lipid content (HP:0009058)2.95479947
55Ketoacidosis (HP:0001993)2.93196676
56Calcaneovalgus deformity (HP:0001848)2.92146311
57EMG: neuropathic changes (HP:0003445)2.84855955
58Abnormal EKG (HP:0003115)2.84512579
59Difficulty climbing stairs (HP:0003551)2.81568910
60Abnormality of fatty-acid metabolism (HP:0004359)2.80779320
61Left ventricular hypertrophy (HP:0001712)2.79822780
62Scapular winging (HP:0003691)2.78889922
63Distal lower limb muscle weakness (HP:0009053)2.78376046
64Muscle stiffness (HP:0003552)2.76302248
65Absent phalangeal crease (HP:0006109)2.72778688
66Exercise intolerance (HP:0003546)2.60710888
67Lactic acidosis (HP:0003128)2.59947204
68Deformed tarsal bones (HP:0008119)2.59124039
69Respiratory failure (HP:0002878)2.58913956
70Mildly elevated creatine phosphokinase (HP:0008180)2.56846574
71Palmoplantar keratoderma (HP:0000982)2.54653390
72Increased intramyocellular lipid droplets (HP:0012240)2.53815979
73Areflexia of lower limbs (HP:0002522)2.53451890
74Conjunctival hamartoma (HP:0100780)2.52819562
75Bulbar palsy (HP:0001283)2.51096015
76Distal lower limb amyotrophy (HP:0008944)2.42739500
77Testicular atrophy (HP:0000029)2.41234889
78Increased variability in muscle fiber diameter (HP:0003557)2.39714839
79Malignant hyperthermia (HP:0002047)2.33805739
80Generalized muscle weakness (HP:0003324)2.33006665
81Neck muscle weakness (HP:0000467)2.32469261
82Limb-girdle muscle atrophy (HP:0003797)2.31080576
83Muscle fiber inclusion bodies (HP:0100299)2.30887460
84Pheochromocytoma (HP:0002666)2.30788513
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.28428534
86Ragged-red muscle fibers (HP:0003200)2.26568855
87Abnormal finger flexion creases (HP:0006143)2.23983090
88Ketosis (HP:0001946)2.23473537
89Abnormality of skeletal muscle fiber size (HP:0012084)2.20600965
90Spinal rigidity (HP:0003306)2.19336344
91Type 1 muscle fiber predominance (HP:0003803)2.16352043
92Respiratory insufficiency due to muscle weakness (HP:0002747)2.14665314
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12563340
94Abnormality of alanine metabolism (HP:0010916)2.12563340
95Hyperalaninemia (HP:0003348)2.12563340
96Abnormality of the shoulder girdle musculature (HP:0001435)2.10648417
97Neoplasm of head and neck (HP:0012288)2.07912642
98Esophageal neoplasm (HP:0100751)2.07912642
99Neuroendocrine neoplasm (HP:0100634)2.07396774
100Lipid accumulation in hepatocytes (HP:0006561)2.07037971
101Generalized aminoaciduria (HP:0002909)2.03491778
102Progressive muscle weakness (HP:0003323)2.02756432
103Weak cry (HP:0001612)2.02626109
104Hip contracture (HP:0003273)2.02381374
105Hyperglycinuria (HP:0003108)2.01844870
106Hamartoma of the eye (HP:0010568)2.01813619
107Increased serum pyruvate (HP:0003542)1.98339506
108Abnormality of glycolysis (HP:0004366)1.98339506
109Rimmed vacuoles (HP:0003805)1.97141563
110Fatigable weakness (HP:0003473)1.95738300
111Abnormality of the neuromuscular junction (HP:0003398)1.95738300
112Slender build (HP:0001533)1.94630770
113Neoplasm of the adrenal gland (HP:0100631)1.92666449
114Abnormality of the foot musculature (HP:0001436)1.90532754
115Proximal amyotrophy (HP:0007126)1.89332670
116Congestive heart failure (HP:0001635)1.89098834
117Gowers sign (HP:0003391)1.89069116
118Hyperinsulinemic hypoglycemia (HP:0000825)1.88533010
119Hyperammonemia (HP:0001987)1.88143947
120Athetosis (HP:0002305)1.87812789
121Muscular dystrophy (HP:0003560)1.87523502
122Large for gestational age (HP:0001520)1.86457082
123Sudden cardiac death (HP:0001645)1.85911428
124Foot dorsiflexor weakness (HP:0009027)1.85659050
125Nausea (HP:0002018)1.84166153
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83800119
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83800119
128Facial diplegia (HP:0001349)1.83394118
129Fetal akinesia sequence (HP:0001989)1.82859310
130Waddling gait (HP:0002515)1.82299945
131Lower limb amyotrophy (HP:0007210)1.77853351
132Renal cortical cysts (HP:0000803)1.74596852
133Abnormality of the hip-girdle musculature (HP:0001445)1.71854566
134Abnormality of the musculature of the pelvis (HP:0001469)1.71854566
135Proximal tubulopathy (HP:0000114)1.66138861
136Shoulder girdle muscle weakness (HP:0003547)1.65740253
137Hyperkalemia (HP:0002153)1.62279011
138Dysmetric saccades (HP:0000641)1.62242678
139Pelvic girdle muscle weakness (HP:0003749)1.61060453
140Muscle fibrillation (HP:0010546)1.57670830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.31043269
2OBSCN4.14052711
3PHKG14.08552866
4PHKG24.08552866
5LMTK23.90364956
6MYLK3.90166457
7PDK33.61949823
8PDK43.61949823
9BCKDK3.11738736
10PIK3CA2.79325443
11DMPK2.77187712
12PKN22.64536069
13TRIB32.57358364
14NEK12.29084904
15MUSK2.26838732
16PDK22.23473259
17PINK12.23335502
18TIE11.93590565
19STK241.66803544
20GRK71.54162820
21PAK31.37764481
22CAMK2D1.31116591
23PRKD11.23425853
24CDC42BPA1.17854330
25ILK1.08337780
26STK38L1.07072972
27STK41.03443274
28MAP3K71.03061354
29MAPK120.98379294
30DAPK30.95124156
31ROCK10.94422423
32WNK40.93716666
33ZAK0.93004699
34MAPKAPK30.90378810
35PRKAA10.89981344
36PKN10.88177645
37PRKAA20.87386733
38MAP2K30.84877624
39MAP3K50.84219708
40ERBB30.82530988
41PDGFRA0.81862327
42NME20.81765129
43UHMK10.79152793
44LIMK10.79086379
45EEF2K0.79084425
46CCNB10.78879838
47RIPK10.76971456
48FLT30.75556876
49MAPK40.74901043
50MARK10.72758843
51NME10.70372291
52TBK10.68504920
53CAMK40.67398111
54TRPM70.65743643
55MAP3K30.64868797
56INSRR0.61418197
57RPS6KC10.60105827
58RPS6KL10.60105827
59DAPK20.59890089
60STK380.59688858
61PAK60.59257417
62ROCK20.58339914
63KDR0.57126555
64KSR20.56981275
65ARAF0.56923443
66CAMK2B0.56323465
67CAMK2A0.54196504
68NEK90.51180955
69RPS6KA60.51136884
70SGK20.50955485
71PRKACB0.50317046
72PDPK10.50129096
73MOS0.49591546
74ICK0.49055410
75MAP3K60.48564901
76TGFBR20.47634091
77WNK10.46367817
78CAMK10.45930128
79MAPK70.44294029
80AKT20.43643817
81PRKACG0.42832809
82EPHB10.41317639
83PRKACA0.41289738
84CAMK2G0.40830004
85PRKCE0.40333007
86PDK10.40089578
87PTK2B0.35537515
88DYRK1B0.34255916
89RAF10.34017213
90SGK2230.30820105
91SGK4940.30820105
92PRKG20.30654395
93PRKD20.29884669
94STK390.29548717
95PRKCH0.29199615
96CAMK1D0.28808019
97RPS6KA10.28759741
98MARK20.28270799
99PTK60.26612147
100EPHB20.26313589
101MAPK100.26153322
102EPHA30.25705402
103MAPK130.25555428
104SIK10.23091961
105RPS6KA20.21891876
106FGFR30.20505741
107TAOK10.20029064
108MAP3K130.18907319
109GRK50.18601557
110MAP3K110.17977527
111PRKD30.17765666
112MTOR0.17385352
113PRKG10.17367166
114SGK10.16814064
115MAPK110.16200494
116STK110.16002744
117SGK30.15927568
118FRK0.15807346
119LATS20.15685543
120PIK3CG0.14650746
121JAK10.14061504
122RPS6KA30.13476179
123MAP2K60.11537276
124ADRBK10.10911575
125RPS6KB10.10865842
126ABL20.10175441
127FER0.10009210
128MAP2K40.09912242
129CAMK1G0.09473296
130PDGFRB0.09334601
131LRRK20.08987437
132MAP3K10.08123767
133MAPKAPK20.07259847
134MAP2K10.07250970
135JAK20.06625002

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.04492841
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.24115009
3* Cardiac muscle contraction_Homo sapiens_hsa042604.06310171
4* Oxidative phosphorylation_Homo sapiens_hsa001903.72354179
5Parkinsons disease_Homo sapiens_hsa050123.69311966
6Propanoate metabolism_Homo sapiens_hsa006403.61579861
7Dilated cardiomyopathy_Homo sapiens_hsa054143.20590495
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.15345705
9Fatty acid degradation_Homo sapiens_hsa000713.11986773
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94335571
11Alzheimers disease_Homo sapiens_hsa050102.72226577
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67761860
13Carbon metabolism_Homo sapiens_hsa012002.64076702
14* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.56710238
15Fatty acid metabolism_Homo sapiens_hsa012122.36688557
16Huntingtons disease_Homo sapiens_hsa050162.36392317
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04236544
18Pyruvate metabolism_Homo sapiens_hsa006202.02498134
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79923828
20Butanoate metabolism_Homo sapiens_hsa006501.65051590
21Viral myocarditis_Homo sapiens_hsa054161.49881948
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49048113
23Fatty acid elongation_Homo sapiens_hsa000621.43554891
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37783992
25PPAR signaling pathway_Homo sapiens_hsa033201.32350083
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30302211
27Biosynthesis of amino acids_Homo sapiens_hsa012301.12965189
28Starch and sucrose metabolism_Homo sapiens_hsa005001.04165284
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94286065
30Adipocytokine signaling pathway_Homo sapiens_hsa049200.94031768
31Tryptophan metabolism_Homo sapiens_hsa003800.93892194
32Long-term potentiation_Homo sapiens_hsa047200.93061276
33Insulin resistance_Homo sapiens_hsa049310.91940473
34Glucagon signaling pathway_Homo sapiens_hsa049220.91720464
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89020144
36beta-Alanine metabolism_Homo sapiens_hsa004100.84675697
37Amphetamine addiction_Homo sapiens_hsa050310.79567443
38Insulin signaling pathway_Homo sapiens_hsa049100.78340966
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78089480
40cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75248593
41Galactose metabolism_Homo sapiens_hsa000520.73238141
42Peroxisome_Homo sapiens_hsa041460.69909518
43Lysine degradation_Homo sapiens_hsa003100.67712342
44Arginine and proline metabolism_Homo sapiens_hsa003300.65946520
45Arginine biosynthesis_Homo sapiens_hsa002200.65295974
46Fatty acid biosynthesis_Homo sapiens_hsa000610.64196412
47Fructose and mannose metabolism_Homo sapiens_hsa000510.63187245
48AMPK signaling pathway_Homo sapiens_hsa041520.63057784
49HIF-1 signaling pathway_Homo sapiens_hsa040660.60134603
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59462328
51Sulfur metabolism_Homo sapiens_hsa009200.57268532
52Calcium signaling pathway_Homo sapiens_hsa040200.55481715
53Melanogenesis_Homo sapiens_hsa049160.54157196
54Phenylalanine metabolism_Homo sapiens_hsa003600.52304859
55Fat digestion and absorption_Homo sapiens_hsa049750.51203564
56Salivary secretion_Homo sapiens_hsa049700.48329021
57Type II diabetes mellitus_Homo sapiens_hsa049300.45335604
58Nitrogen metabolism_Homo sapiens_hsa009100.44560409
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.44076761
60Focal adhesion_Homo sapiens_hsa045100.43661316
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43445575
62Cholinergic synapse_Homo sapiens_hsa047250.43036135
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.42200741
64Histidine metabolism_Homo sapiens_hsa003400.42045868
65Metabolic pathways_Homo sapiens_hsa011000.41874098
66Tight junction_Homo sapiens_hsa045300.41710231
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41221728
68Morphine addiction_Homo sapiens_hsa050320.40020687
69Oxytocin signaling pathway_Homo sapiens_hsa049210.39850810
70MAPK signaling pathway_Homo sapiens_hsa040100.39083080
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36253880
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35873836
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35633141
74GABAergic synapse_Homo sapiens_hsa047270.34285638
75Cocaine addiction_Homo sapiens_hsa050300.34190608
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33373019
77Long-term depression_Homo sapiens_hsa047300.30299696
78Folate biosynthesis_Homo sapiens_hsa007900.30154489
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30108650
80Dopaminergic synapse_Homo sapiens_hsa047280.29610384
81Regulation of autophagy_Homo sapiens_hsa041400.28024441
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.27713854
83Glycerolipid metabolism_Homo sapiens_hsa005610.25291018
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.25201963
85Gastric acid secretion_Homo sapiens_hsa049710.24264624
86Renin secretion_Homo sapiens_hsa049240.23834247
87Glutamatergic synapse_Homo sapiens_hsa047240.22967163
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22131045
89cAMP signaling pathway_Homo sapiens_hsa040240.22047853
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20946063
91Tyrosine metabolism_Homo sapiens_hsa003500.20727529
92ECM-receptor interaction_Homo sapiens_hsa045120.19838569
93Olfactory transduction_Homo sapiens_hsa047400.18622469
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18342687
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18085933
96Insulin secretion_Homo sapiens_hsa049110.15175342
97Pentose phosphate pathway_Homo sapiens_hsa000300.14382995
98Circadian rhythm_Homo sapiens_hsa047100.13379662
99Adherens junction_Homo sapiens_hsa045200.11477121
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09147215
101Amoebiasis_Homo sapiens_hsa051460.08690544
102Bile secretion_Homo sapiens_hsa049760.07216066
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.06212679
104Sulfur relay system_Homo sapiens_hsa041220.05679181
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.05465128
106Pancreatic secretion_Homo sapiens_hsa049720.05273281
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05097807
108Renal cell carcinoma_Homo sapiens_hsa052110.04981650
109VEGF signaling pathway_Homo sapiens_hsa043700.02723708
110Gap junction_Homo sapiens_hsa045400.02300991
111Ovarian steroidogenesis_Homo sapiens_hsa049130.01931878
112Linoleic acid metabolism_Homo sapiens_hsa005910.01575996
113GnRH signaling pathway_Homo sapiens_hsa049120.00520785
114Glutathione metabolism_Homo sapiens_hsa00480-0.0614829
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0606634
116Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0526623
117mTOR signaling pathway_Homo sapiens_hsa04150-0.0450310
118FoxO signaling pathway_Homo sapiens_hsa04068-0.0443669
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0404570
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964-0.0253713
121Circadian entrainment_Homo sapiens_hsa04713-0.0252537
122Proteoglycans in cancer_Homo sapiens_hsa05205-0.0204517
123Platelet activation_Homo sapiens_hsa04611-0.0112278
124ABC transporters_Homo sapiens_hsa02010-0.0083776

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