COX7A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.70502715
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.70502715
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.93719489
4respiratory electron transport chain (GO:0022904)7.90844235
5electron transport chain (GO:0022900)7.71452358
6chaperone-mediated protein transport (GO:0072321)5.69515958
7ATP biosynthetic process (GO:0006754)5.10613371
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.06352863
9ribosomal small subunit assembly (GO:0000028)4.94725587
10* hydrogen ion transmembrane transport (GO:1902600)4.88076700
11protein neddylation (GO:0045116)4.84451858
12purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.83080636
13purine nucleoside triphosphate biosynthetic process (GO:0009145)4.72601963
14sequestering of actin monomers (GO:0042989)4.69105259
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.52749725
16NADH dehydrogenase complex assembly (GO:0010257)4.52749725
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.52749725
18protein complex biogenesis (GO:0070271)4.47417639
19* proton transport (GO:0015992)4.28329501
20inner mitochondrial membrane organization (GO:0007007)4.21899167
21* hydrogen transport (GO:0006818)4.20312685
22proteasome assembly (GO:0043248)4.19505495
23ribonucleoside triphosphate biosynthetic process (GO:0009201)4.14891223
24neuron cell-cell adhesion (GO:0007158)4.01641974
25mitochondrial respiratory chain complex assembly (GO:0033108)4.00455821
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91644199
27translational initiation (GO:0006413)3.88451417
28GTP biosynthetic process (GO:0006183)3.86716067
29cytochrome complex assembly (GO:0017004)3.85420636
30axon ensheathment in central nervous system (GO:0032291)3.78588845
31central nervous system myelination (GO:0022010)3.78588845
32ribosomal large subunit biogenesis (GO:0042273)3.77980550
33maturation of SSU-rRNA (GO:0030490)3.77403376
34translation (GO:0006412)3.73904249
35regulation of oxidative phosphorylation (GO:0002082)3.70085675
36ribosomal small subunit biogenesis (GO:0042274)3.69260687
37transcription elongation from RNA polymerase III promoter (GO:0006385)3.66265768
38termination of RNA polymerase III transcription (GO:0006386)3.66265768
39ATP hydrolysis coupled proton transport (GO:0015991)3.58339596
40energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.58339596
41protein complex disassembly (GO:0043241)3.53626376
42oxidative phosphorylation (GO:0006119)3.52773125
43viral transcription (GO:0019083)3.50499804
44nucleoside triphosphate biosynthetic process (GO:0009142)3.49590558
45behavioral response to nicotine (GO:0035095)3.48089750
46substantia nigra development (GO:0021762)3.45511612
47macromolecular complex disassembly (GO:0032984)3.44647211
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38747019
49protein-cofactor linkage (GO:0018065)3.36976543
50protein targeting to membrane (GO:0006612)3.35611752
51translational termination (GO:0006415)3.33480411
52regulation of dopamine metabolic process (GO:0042053)3.32115584
53regulation of catecholamine metabolic process (GO:0042069)3.32115584
54water-soluble vitamin biosynthetic process (GO:0042364)3.31430397
55long-chain fatty acid biosynthetic process (GO:0042759)3.30192479
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16737288
57dopamine transport (GO:0015872)3.16644724
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16508900
59fatty acid elongation (GO:0030497)3.14469104
60regulation of cellular amino acid metabolic process (GO:0006521)3.14028149
61dopamine biosynthetic process (GO:0042416)3.13235536
62cotranslational protein targeting to membrane (GO:0006613)3.12566786
63UTP biosynthetic process (GO:0006228)3.12344415
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10488911
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10488911
66presynaptic membrane assembly (GO:0097105)3.09817222
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05664582
68regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04752821
69mitochondrial transport (GO:0006839)3.04063641
70cellular component biogenesis (GO:0044085)3.03538954
71protein targeting to ER (GO:0045047)3.03436197
72negative regulation of ligase activity (GO:0051352)3.03039749
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03039749
74presynaptic membrane organization (GO:0097090)3.01972631
75calcium-mediated signaling using intracellular calcium source (GO:0035584)2.99802009
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98044344
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96447697
78regulation of cellular respiration (GO:0043457)2.94294365
79protein targeting to mitochondrion (GO:0006626)2.93770545
80neuronal action potential propagation (GO:0019227)2.93103785
81establishment of protein localization to mitochondrion (GO:0072655)2.92681098
82establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92515711
83protein localization to endoplasmic reticulum (GO:0070972)2.92469291
84negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.92151616
85cullin deneddylation (GO:0010388)2.91094064
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.90231235
87signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90117341
88signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90117341
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90117341
90vocalization behavior (GO:0071625)2.88125462
91platelet dense granule organization (GO:0060155)2.87338450
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87094193
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87094193
94positive regulation of synapse assembly (GO:0051965)2.86751672
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85413524
96neuron recognition (GO:0008038)2.85286982
97generation of precursor metabolites and energy (GO:0006091)2.84693200
98intracellular protein transmembrane import (GO:0044743)2.80636320
99regulation of mitochondrial translation (GO:0070129)2.80541840
100rRNA modification (GO:0000154)2.79193675
101DNA damage response, detection of DNA damage (GO:0042769)2.78928846
102organelle disassembly (GO:1903008)2.78885412
103protein localization to mitochondrion (GO:0070585)2.78834446
104regulation of glutamate secretion (GO:0014048)2.78798112
105cellular protein complex disassembly (GO:0043624)2.78540694
106signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75442131
107signal transduction involved in DNA damage checkpoint (GO:0072422)2.75442131
108UTP metabolic process (GO:0046051)2.75369918
109signal transduction involved in cell cycle checkpoint (GO:0072395)2.74304250
110positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73143456
111mRNA catabolic process (GO:0006402)2.71736430
112viral life cycle (GO:0019058)2.70353925
113gamma-aminobutyric acid signaling pathway (GO:0007214)2.70059135
114regulation of protein kinase A signaling (GO:0010738)2.68736637
115spliceosomal snRNP assembly (GO:0000387)2.66572678
116protein localization to synapse (GO:0035418)2.65641188
117protein deneddylation (GO:0000338)2.64492866
118spliceosomal complex assembly (GO:0000245)2.64093805
119translational elongation (GO:0006414)2.58493863
120positive regulation of ligase activity (GO:0051351)2.57896389
121pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57178326
122nucleoside diphosphate phosphorylation (GO:0006165)2.57050970
123purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.56735428
124purine nucleoside monophosphate biosynthetic process (GO:0009127)2.56735428
125synaptic vesicle exocytosis (GO:0016079)2.56547779
126guanosine-containing compound biosynthetic process (GO:1901070)2.55147983
127aerobic respiration (GO:0009060)2.54624085
128intracellular protein transmembrane transport (GO:0065002)2.53539595
129neural nucleus development (GO:0048857)2.52321516
130behavioral response to cocaine (GO:0048148)2.51771453
131protein targeting (GO:0006605)2.50865373
132protein transmembrane transport (GO:0071806)2.50068160
133negative regulation of protein localization to cell surface (GO:2000009)2.49731854
134synaptic transmission, dopaminergic (GO:0001963)2.47954390
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47870239
136establishment of integrated proviral latency (GO:0075713)2.47042253
137positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.45972050
138positive regulation of response to oxidative stress (GO:1902884)2.45153360
139positive regulation of cellular response to oxidative stress (GO:1900409)2.45153360
140respiratory chain complex IV assembly (GO:0008535)2.43866698
141protein localization to cilium (GO:0061512)2.43062178
142purine nucleoside biosynthetic process (GO:0042451)2.41216102
143purine ribonucleoside biosynthetic process (GO:0046129)2.41216102
144transmission of nerve impulse (GO:0019226)2.41039439
145regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39692658
146CTP metabolic process (GO:0046036)2.36033232
147CTP biosynthetic process (GO:0006241)2.36033232
148positive regulation of protein homodimerization activity (GO:0090073)2.35470408
149neuron remodeling (GO:0016322)2.35371135
150detection of calcium ion (GO:0005513)2.35058958
151glutamate receptor signaling pathway (GO:0007215)2.34666795
152cellular response to epinephrine stimulus (GO:0071872)2.34163507
153establishment of viral latency (GO:0019043)2.34057968
154mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.3044843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19244025
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.98944202
3GBX2_23144817_ChIP-Seq_PC3_Human3.02877716
4TAF15_26573619_Chip-Seq_HEK293_Human2.82475289
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69137503
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67333218
7VDR_22108803_ChIP-Seq_LS180_Human2.59320068
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57203714
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48241282
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47951890
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.46970924
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42142826
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.42103717
14* ELK1_19687146_ChIP-ChIP_HELA_Human2.39955685
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.38971504
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15181814
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12755906
18* VDR_23849224_ChIP-Seq_CD4+_Human2.12143553
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.11253656
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09777892
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09367722
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08146893
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.05709812
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00762326
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00554105
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98924369
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98466652
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98466652
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.93026418
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91315824
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89714860
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.88842632
33* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88738531
34FUS_26573619_Chip-Seq_HEK293_Human1.87503742
35MYC_18940864_ChIP-ChIP_HL60_Human1.80130868
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75002163
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73870165
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73274460
39FOXP3_21729870_ChIP-Seq_TREG_Human1.71650398
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.69390867
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67493105
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67059898
43* TTF2_22483619_ChIP-Seq_HELA_Human1.67013515
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66809701
45REST_21632747_ChIP-Seq_MESCs_Mouse1.66686499
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63576801
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.62811022
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62469484
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.60516537
50P300_19829295_ChIP-Seq_ESCs_Human1.58852491
51ZNF274_21170338_ChIP-Seq_K562_Hela1.58162567
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57445514
53XRN2_22483619_ChIP-Seq_HELA_Human1.55032544
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52345298
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49725693
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48078483
57ER_23166858_ChIP-Seq_MCF-7_Human1.47467539
58DCP1A_22483619_ChIP-Seq_HELA_Human1.43520991
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43098628
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.41246159
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41104786
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40264575
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40115829
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39515782
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38075676
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.37466513
67RNF2_27304074_Chip-Seq_NSC_Mouse1.36858697
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34494864
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33137283
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.32691805
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32146559
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30991852
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30598020
74GABP_19822575_ChIP-Seq_HepG2_Human1.29412356
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28633221
76* ELK1_22589737_ChIP-Seq_MCF10A_Human1.27781645
77* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26633872
78TP53_22573176_ChIP-Seq_HFKS_Human1.25213457
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25186703
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24164362
81* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23538274
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22968783
83* ETS1_20019798_ChIP-Seq_JURKAT_Human1.20682466
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.20530125
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20081255
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17041404
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13297117
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13157624
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.13034317
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12658558
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11642939
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10881901
93IRF1_19129219_ChIP-ChIP_H3396_Human1.09939278
94SMAD4_21799915_ChIP-Seq_A2780_Human1.09753068
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09200562
96IGF1R_20145208_ChIP-Seq_DFB_Human1.09073470
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.08199592
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07810900
99AR_21572438_ChIP-Seq_LNCaP_Human1.04784672
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04439106
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.04116400
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04108847
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04034571
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02204222
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01349615
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01138643
107EWS_26573619_Chip-Seq_HEK293_Human1.00860979
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00836086
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99688578
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99629764
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98310380
112FOXA1_25329375_ChIP-Seq_VCAP_Human0.97549292
113FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97549292
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96437276
115HTT_18923047_ChIP-ChIP_STHdh_Human0.96093944
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96091797
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95641933
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95052415
119* JUN_21703547_ChIP-Seq_K562_Human0.94387659
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.94386889
121* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94257393
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.92649061
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92057204
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91913399
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.91703276
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.90737780
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.90450901
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89967219
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89934784
130* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89132484
131FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88083180
132BCAT_22108803_ChIP-Seq_LS180_Human0.86435491
133NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86211499
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86170806
135RING1B_27294783_Chip-Seq_ESCs_Mouse0.85775352
136ERG_20517297_ChIP-Seq_VCAP_Human0.85449375
137NANOG_19829295_ChIP-Seq_ESCs_Human0.84715137
138SOX2_19829295_ChIP-Seq_ESCs_Human0.84715137
139KDM2B_26808549_Chip-Seq_REH_Human0.84010176
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82836982
141RARB_27405468_Chip-Seq_BRAIN_Mouse0.82595073
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81914814
143ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81346584
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80662703
145NCOR_22424771_ChIP-Seq_293T_Human0.80544579
146AR_20517297_ChIP-Seq_VCAP_Human0.80531582
147ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79960943
148PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79897334
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79745924
150P53_22387025_ChIP-Seq_ESCs_Mouse0.79422513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.31778620
2MP0001529_abnormal_vocalization3.54166813
3MP0002837_dystrophic_cardiac_calcinosis3.44391538
4MP0009379_abnormal_foot_pigmentation3.40481508
5MP0006276_abnormal_autonomic_nervous3.00899829
6MP0001905_abnormal_dopamine_level2.66267108
7MP0001968_abnormal_touch/_nociception2.48194892
8MP0009745_abnormal_behavioral_response2.46615241
9MP0003635_abnormal_synaptic_transmissio2.39042245
10MP0002736_abnormal_nociception_after2.36550783
11MP0002064_seizures2.35940030
12MP0004270_analgesia2.30122434
13MP0002938_white_spotting2.28075532
14MP0002272_abnormal_nervous_system2.25870153
15MP0009046_muscle_twitch2.22333556
16MP0001440_abnormal_grooming_behavior2.21011291
17MP0004859_abnormal_synaptic_plasticity2.08251176
18MP0003646_muscle_fatigue2.06599959
19MP0002735_abnormal_chemical_nociception2.04568104
20MP0004142_abnormal_muscle_tone2.04474856
21MP0002572_abnormal_emotion/affect_behav2.04381193
22MP0001486_abnormal_startle_reflex1.97855270
23MP0002734_abnormal_mechanical_nocicepti1.96333215
24MP0005423_abnormal_somatic_nervous1.88808512
25MP0000778_abnormal_nervous_system1.88174950
26MP0003011_delayed_dark_adaptation1.85833470
27MP0002063_abnormal_learning/memory/cond1.85394932
28MP0003186_abnormal_redox_activity1.82692389
29MP0002733_abnormal_thermal_nociception1.77532045
30MP0001970_abnormal_pain_threshold1.71883321
31MP0003136_yellow_coat_color1.70897725
32MP0000751_myopathy1.68522199
33MP0002067_abnormal_sensory_capabilities1.67802392
34MP0004742_abnormal_vestibular_system1.62408253
35MP0001501_abnormal_sleep_pattern1.60328335
36MP0002822_catalepsy1.59669249
37MP0006036_abnormal_mitochondrial_physio1.58988475
38MP0005386_behavior/neurological_phenoty1.58135581
39MP0004924_abnormal_behavior1.58135581
40MP0003329_amyloid_beta_deposits1.58053346
41MP0003806_abnormal_nucleotide_metabolis1.57295581
42MP0001984_abnormal_olfaction1.57233205
43MP0005084_abnormal_gallbladder_morpholo1.57221456
44MP0000566_synostosis1.54048713
45MP0004215_abnormal_myocardial_fiber1.52927998
46MP0003121_genomic_imprinting1.52474031
47MP0004133_heterotaxia1.52462182
48MP0003787_abnormal_imprinting1.51287999
49MP0008877_abnormal_DNA_methylation1.50591318
50MP0005409_darkened_coat_color1.47636817
51MP0008995_early_reproductive_senescence1.45285149
52MP0002184_abnormal_innervation1.44662055
53MP0001188_hyperpigmentation1.43490495
54MP0003718_maternal_effect1.43065597
55MP0004036_abnormal_muscle_relaxation1.43056623
56MP0001485_abnormal_pinna_reflex1.39765666
57MP0002277_abnormal_respiratory_mucosa1.37784928
58MP0008058_abnormal_DNA_repair1.34471756
59MP0003938_abnormal_ear_development1.31184049
60MP0002332_abnormal_exercise_endurance1.30638682
61MP0000920_abnormal_myelination1.30637142
62MP0010030_abnormal_orbit_morphology1.27256446
63MP0006035_abnormal_mitochondrial_morpho1.24642870
64MP0005379_endocrine/exocrine_gland_phen1.24618566
65MP0002557_abnormal_social/conspecific_i1.22841859
66MP0006072_abnormal_retinal_apoptosis1.22440017
67MP0002909_abnormal_adrenal_gland1.22196156
68MP0004145_abnormal_muscle_electrophysio1.21840812
69MP0002163_abnormal_gland_morphology1.21297646
70MP0005551_abnormal_eye_electrophysiolog1.20037898
71MP0002653_abnormal_ependyma_morphology1.19571857
72MP0001727_abnormal_embryo_implantation1.17906956
73MP0008875_abnormal_xenobiotic_pharmacok1.17797142
74MP0002638_abnormal_pupillary_reflex1.17462734
75MP0000569_abnormal_digit_pigmentation1.17026875
76MP0004147_increased_porphyrin_level1.16554380
77MP0002102_abnormal_ear_morphology1.15759739
78MP0003890_abnormal_embryonic-extraembry1.15159469
79MP0002066_abnormal_motor_capabilities/c1.13829476
80MP0003137_abnormal_impulse_conducting1.13675300
81MP0010386_abnormal_urinary_bladder1.13156976
82MP0005646_abnormal_pituitary_gland1.12903694
83MP0001963_abnormal_hearing_physiology1.12607115
84MP0000026_abnormal_inner_ear1.11153438
85MP0001293_anophthalmia1.10704732
86MP0005171_absent_coat_pigmentation1.10494538
87MP0005410_abnormal_fertilization1.07087898
88MP0000749_muscle_degeneration1.06453723
89MP0002882_abnormal_neuron_morphology1.06425370
90MP0004085_abnormal_heartbeat1.03479261
91MP0005535_abnormal_body_temperature1.02993261
92MP0004885_abnormal_endolymph1.01565931
93MP0002752_abnormal_somatic_nervous1.01295560
94MP0002876_abnormal_thyroid_physiology0.98859858
95MP0003123_paternal_imprinting0.98485324
96MP0002229_neurodegeneration0.98155315
97MP0004043_abnormal_pH_regulation0.97420930
98MP0002751_abnormal_autonomic_nervous0.95865281
99MP0003195_calcinosis0.95205675
100MP0000538_abnormal_urinary_bladder0.94565300
101MP0002095_abnormal_skin_pigmentation0.94146824
102MP0004484_altered_response_of0.93279163
103MP0001664_abnormal_digestion0.92588900
104MP0005408_hypopigmentation0.92446601
105MP0000955_abnormal_spinal_cord0.92140331
106MP0002234_abnormal_pharynx_morphology0.90731509
107MP0008872_abnormal_physiological_respon0.89920726
108MP0003122_maternal_imprinting0.89746708
109MP0005195_abnormal_posterior_eye0.88836348
110MP0005330_cardiomyopathy0.87547206
111MP0002090_abnormal_vision0.87088088
112MP0003950_abnormal_plasma_membrane0.87013633
113MP0005332_abnormal_amino_acid0.85604655
114MP0000372_irregular_coat_pigmentation0.84860887
115MP0005620_abnormal_muscle_contractility0.84640317
116MP0002972_abnormal_cardiac_muscle0.84255183
117MP0001502_abnormal_circadian_rhythm0.83814765
118MP0003283_abnormal_digestive_organ0.83151803
119MP0003786_premature_aging0.82439979
120MP0002160_abnormal_reproductive_system0.81426926
121MP0001986_abnormal_taste_sensitivity0.80444140
122MP0001764_abnormal_homeostasis0.79434861
123MP0004381_abnormal_hair_follicle0.79007385
124MP0003634_abnormal_glial_cell0.78990278
125MP0005394_taste/olfaction_phenotype0.78950971
126MP0005499_abnormal_olfactory_system0.78950971
127MP0000631_abnormal_neuroendocrine_gland0.78043682
128MP0008569_lethality_at_weaning0.77839691
129MP0000462_abnormal_digestive_system0.77175178
130MP0008789_abnormal_olfactory_epithelium0.76355586
131MP0005645_abnormal_hypothalamus_physiol0.73879673
132MP0002152_abnormal_brain_morphology0.72548291
133MP0005253_abnormal_eye_physiology0.68321855
134MP0002106_abnormal_muscle_physiology0.67702230
135MP0004811_abnormal_neuron_physiology0.65717196
136MP0000230_abnormal_systemic_arterial0.65227745
137MP0006292_abnormal_olfactory_placode0.65213796
138MP0000013_abnormal_adipose_tissue0.64995269

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.50376056
2Abnormal mitochondria in muscle tissue (HP:0008316)6.71669988
3Mitochondrial inheritance (HP:0001427)6.48599250
4Progressive macrocephaly (HP:0004481)6.44117052
5Acute encephalopathy (HP:0006846)6.15321362
6Increased CSF lactate (HP:0002490)5.31138408
7Increased hepatocellular lipid droplets (HP:0006565)5.24589801
8Hepatocellular necrosis (HP:0001404)4.98889739
9Lipid accumulation in hepatocytes (HP:0006561)4.74144848
10Renal Fanconi syndrome (HP:0001994)4.58504563
11Optic disc pallor (HP:0000543)4.49059158
12Cerebral edema (HP:0002181)4.47418009
13Hepatic necrosis (HP:0002605)4.19711757
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.12965853
15Increased serum pyruvate (HP:0003542)4.11846262
16Abnormality of glycolysis (HP:0004366)4.11846262
17Increased intramyocellular lipid droplets (HP:0012240)3.98521422
18Leukodystrophy (HP:0002415)3.86457118
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.69182744
20Exercise intolerance (HP:0003546)3.68860885
21Respiratory failure (HP:0002878)3.66686283
22Reticulocytopenia (HP:0001896)3.51523889
23Myokymia (HP:0002411)3.49470233
24Focal motor seizures (HP:0011153)3.48161299
25Increased muscle lipid content (HP:0009058)3.42883246
26Lactic acidosis (HP:0003128)3.37810996
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.29506189
283-Methylglutaconic aciduria (HP:0003535)3.23909760
29Exertional dyspnea (HP:0002875)3.13249180
30Congenital, generalized hypertrichosis (HP:0004540)3.09510740
31Parakeratosis (HP:0001036)3.07817184
32Abnormality of renal resorption (HP:0011038)3.03141434
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.94142669
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.94142669
35X-linked dominant inheritance (HP:0001423)2.89228285
36Increased serum lactate (HP:0002151)2.87172826
37Molar tooth sign on MRI (HP:0002419)2.84308576
38Abnormality of midbrain morphology (HP:0002418)2.84308576
39Respiratory difficulties (HP:0002880)2.75326760
40Pancreatic cysts (HP:0001737)2.69407298
41Pancreatic fibrosis (HP:0100732)2.67634846
42Abnormality of cells of the erythroid lineage (HP:0012130)2.66610766
43Sensory axonal neuropathy (HP:0003390)2.65450534
44Muscle hypertrophy of the lower extremities (HP:0008968)2.61904297
45Hyperphosphaturia (HP:0003109)2.60315214
46Pheochromocytoma (HP:0002666)2.56010461
47Neuroendocrine neoplasm (HP:0100634)2.49479093
48Generalized aminoaciduria (HP:0002909)2.49006184
49Methylmalonic acidemia (HP:0002912)2.48057685
50True hermaphroditism (HP:0010459)2.46473173
51Nephronophthisis (HP:0000090)2.42506750
52Atonic seizures (HP:0010819)2.38360004
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37692350
54Degeneration of the lateral corticospinal tracts (HP:0002314)2.37692350
55Abnormality of urine glucose concentration (HP:0011016)2.35975943
56Glycosuria (HP:0003076)2.35975943
57Calf muscle hypertrophy (HP:0008981)2.31865687
58Limb dystonia (HP:0002451)2.28496747
59Pallor (HP:0000980)2.26665549
60Septo-optic dysplasia (HP:0100842)2.25793366
61Methylmalonic aciduria (HP:0012120)2.25467183
62Abnormal urine phosphate concentration (HP:0012599)2.20766323
63Congenital ichthyosiform erythroderma (HP:0007431)2.19664048
64Emotional lability (HP:0000712)2.18647692
65Cerebral hemorrhage (HP:0001342)2.18267314
66CNS demyelination (HP:0007305)2.17607720
67Sclerocornea (HP:0000647)2.17604934
68Hyperventilation (HP:0002883)2.15863909
69Macrocytic anemia (HP:0001972)2.11784738
70Neurofibrillary tangles (HP:0002185)2.10990423
71Absence seizures (HP:0002121)2.10305117
72Lethargy (HP:0001254)2.10033398
73Abnormality of the labia minora (HP:0012880)2.08241763
74Abnormal number of erythroid precursors (HP:0012131)2.07778310
75Abnormal pupillary function (HP:0007686)2.04077787
76Retinal dysplasia (HP:0007973)2.03981533
77Focal seizures (HP:0007359)2.03416571
78Sudden death (HP:0001699)2.02242675
79Cerebral inclusion bodies (HP:0100314)2.00591429
80Dialeptic seizures (HP:0011146)2.00564984
81Medial flaring of the eyebrow (HP:0010747)2.00523954
82Abnormal ciliary motility (HP:0012262)2.00433799
83Poor suck (HP:0002033)1.98234213
84Type I transferrin isoform profile (HP:0003642)1.94211133
85Visual hallucinations (HP:0002367)1.90628438
86Delusions (HP:0000746)1.88427917
87Anxiety (HP:0000739)1.88177599
88Amblyopia (HP:0000646)1.87507755
89Nephrogenic diabetes insipidus (HP:0009806)1.86164548
90Amniotic constriction ring (HP:0009775)1.86117906
91Abnormality of placental membranes (HP:0011409)1.86117906
92Aplastic anemia (HP:0001915)1.82193697
93Progressive external ophthalmoplegia (HP:0000590)1.81543843
94Abnormality of the renal medulla (HP:0100957)1.81442626
95Abnormal respiratory motile cilium morphology (HP:0005938)1.80204045
96Abnormal respiratory epithelium morphology (HP:0012253)1.80204045
97Renal tubular dysfunction (HP:0000124)1.78890027
98Hyperglycinemia (HP:0002154)1.78780379
99Congenital stationary night blindness (HP:0007642)1.78203314
100Colon cancer (HP:0003003)1.77392177
101Absent septum pellucidum (HP:0001331)1.76323543
102Epileptic encephalopathy (HP:0200134)1.76212502
103Hypothermia (HP:0002045)1.75970249
104Polyphagia (HP:0002591)1.75376748
105Gait imbalance (HP:0002141)1.74222322
106Abnormality of secondary sexual hair (HP:0009888)1.71166323
107Abnormality of the axillary hair (HP:0100134)1.71166323
108Renal cortical cysts (HP:0000803)1.70837462
109Optic nerve hypoplasia (HP:0000609)1.69416470
110Male pseudohermaphroditism (HP:0000037)1.69057023
111Broad-based gait (HP:0002136)1.68489585
112Generalized tonic-clonic seizures (HP:0002069)1.68472668
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.68441938
114Absent/shortened dynein arms (HP:0200106)1.68441938
115Blindness (HP:0000618)1.67374657
116Concave nail (HP:0001598)1.66760996
117Oral leukoplakia (HP:0002745)1.65861860
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65715428
119Dicarboxylic aciduria (HP:0003215)1.65715428
120Abnormal respiratory motile cilium physiology (HP:0012261)1.65423546
121Hypoplastic left heart (HP:0004383)1.64119620
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63725069
123Vaginal atresia (HP:0000148)1.62027327
124Neoplasm of head and neck (HP:0012288)1.61192742
125Esophageal neoplasm (HP:0100751)1.61192742
126Hypoplasia of the pons (HP:0012110)1.61019577
127Anencephaly (HP:0002323)1.60924609
128Abnormality of vitamin B metabolism (HP:0004340)1.60423175
129Genital tract atresia (HP:0001827)1.60213684
130Vomiting (HP:0002013)1.60121826
131Abnormality of the renal cortex (HP:0011035)1.59622140
132Type II lissencephaly (HP:0007260)1.59414822
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.59346792
134Esotropia (HP:0000565)1.59218187
135Congenital primary aphakia (HP:0007707)1.58239582
136Abnormality of the anterior horn cell (HP:0006802)1.57785679
137Degeneration of anterior horn cells (HP:0002398)1.57785679
138Abnormality of the corticospinal tract (HP:0002492)1.57715627
139Aplasia/hypoplasia of the uterus (HP:0008684)1.57593467
140Abnormal gallbladder physiology (HP:0012438)1.56726310
141Cholecystitis (HP:0001082)1.56726310
142Absent thumb (HP:0009777)1.56662704
143Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.54816189
144Hypoglycemic coma (HP:0001325)1.54524890
145Rib fusion (HP:0000902)1.54389260
146Febrile seizures (HP:0002373)1.52495452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.16636593
2MAP3K123.63940723
3NME13.28134859
4STK393.09168026
5PNCK2.99304699
6CASK2.77993339
7ZAK2.65436074
8MYLK2.55775476
9OXSR12.42003544
10PBK2.11248517
11EPHA42.09699631
12WNK42.09548711
13NME22.03978325
14GRK52.01648329
15GRK71.87822950
16MST41.87811440
17MAP2K71.86525221
18MAP3K41.86343149
19ARAF1.84007234
20NTRK31.79640957
21STK161.75281724
22MARK11.74619181
23CDK191.72495554
24TNIK1.70140656
25MAP4K21.68671455
26TLK11.64827491
27CDC71.62826903
28BCR1.60220396
29RIPK41.57317961
30LIMK11.50654838
31FGR1.45519074
32NUAK11.44981581
33PINK11.39533134
34UHMK11.38325793
35GRK11.37039698
36MUSK1.36955743
37TAF11.35402269
38CAMK2B1.32744114
39PLK21.26036456
40MAPK131.22122597
41BMPR21.21499088
42CAMK2A1.20724229
43OBSCN1.19873225
44NEK11.19813918
45CSNK1G31.17688367
46MINK11.16166654
47PKN11.14605715
48PLK31.14277132
49MAP2K41.14103004
50MAPKAPK51.13418128
51CAMK2D1.09912027
52WNK31.04733838
53BMPR1B1.02622024
54DAPK31.01567657
55NTRK21.01147545
56INSRR1.00790297
57TRIM281.00748734
58ROCK20.99696379
59EPHB20.97269458
60PHKG10.96947439
61PHKG20.96947439
62WEE10.96361148
63ADRBK20.96241194
64DYRK20.96098397
65CSNK1G20.94179818
66PTK2B0.90861297
67ADRBK10.90383342
68PLK40.85698497
69FRK0.85133780
70TESK10.84928878
71CAMK2G0.82790164
72MAP3K90.82216153
73VRK10.79812807
74NTRK10.77265224
75PRKCE0.77220194
76DYRK30.76690866
77CDK50.75251799
78CDK140.74323117
79PAK30.72752790
80PRKCG0.71400881
81PDK30.70074220
82PDK40.70074220
83PLK10.69402637
84PASK0.68915814
85CSNK1G10.68449223
86PIM20.66666704
87BRAF0.66439168
88ABL20.66125687
89PRKACA0.65095650
90CDK150.63409265
91CDK180.62958226
92ERBB30.62027900
93GRK60.61983657
94CSNK1A1L0.61846266
95CSNK2A20.61618991
96DAPK10.61029458
97BUB10.60531852
98CDK11A0.59495885
99FES0.58243015
100EIF2AK30.57648922
101DAPK20.56750911
102AURKB0.56644854
103CHEK20.56470513
104CSNK2A10.52818751
105ILK0.52169878
106DYRK1A0.51030193
107CDK80.49687460
108TESK20.49356444
109RPS6KA50.48654656
110LMTK20.48628048
111MKNK10.48557382
112PRKCI0.48103744
113CSNK1E0.45964902
114MKNK20.45736114
115CSNK1A10.45543580
116CCNB10.45538068
117TTK0.45032890
118PAK60.44922705
119IRAK20.44435089
120MAP3K110.43962875
121PRPF4B0.43010160
122SRPK10.42221970
123PDK20.41877498
124WNK10.40871989
125ROCK10.39487884
126MAPK120.37194451
127STK110.36936794
128MAPK40.35545238
129EIF2AK10.35277375
130PRKG10.34202702
131AURKA0.33955737
132PRKCQ0.33933725
133MAPK150.33634007
134PRKCA0.32216769
135BCKDK0.32030881
136SIK20.30011667
137PRKACB0.29866475

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.74153740
2Parkinsons disease_Homo sapiens_hsa050125.63313226
3Alzheimers disease_Homo sapiens_hsa050104.52014082
4Huntingtons disease_Homo sapiens_hsa050163.96370017
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.48879102
6* Cardiac muscle contraction_Homo sapiens_hsa042603.16866316
7Ribosome_Homo sapiens_hsa030103.11566347
8Collecting duct acid secretion_Homo sapiens_hsa049662.29861561
9Proteasome_Homo sapiens_hsa030502.12599387
10Nicotine addiction_Homo sapiens_hsa050332.11579134
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98836448
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97865984
13Protein export_Homo sapiens_hsa030601.91538006
14Fatty acid elongation_Homo sapiens_hsa000621.65293157
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53635197
16Mismatch repair_Homo sapiens_hsa034301.52478033
17Homologous recombination_Homo sapiens_hsa034401.51696755
18Folate biosynthesis_Homo sapiens_hsa007901.39391391
19Synaptic vesicle cycle_Homo sapiens_hsa047211.39299480
20Serotonergic synapse_Homo sapiens_hsa047261.38470009
21RNA polymerase_Homo sapiens_hsa030201.34697491
22Vibrio cholerae infection_Homo sapiens_hsa051101.33713249
23GABAergic synapse_Homo sapiens_hsa047271.33543203
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30524682
25Sulfur metabolism_Homo sapiens_hsa009201.25867161
26Basal transcription factors_Homo sapiens_hsa030221.20212403
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.18263678
28DNA replication_Homo sapiens_hsa030301.16642319
29Pyruvate metabolism_Homo sapiens_hsa006201.15346377
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15317966
31Taste transduction_Homo sapiens_hsa047421.14527667
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14175203
33Spliceosome_Homo sapiens_hsa030401.12039352
34Glutamatergic synapse_Homo sapiens_hsa047241.11782230
35Morphine addiction_Homo sapiens_hsa050321.11478882
36Nucleotide excision repair_Homo sapiens_hsa034201.10898383
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10883290
38Ether lipid metabolism_Homo sapiens_hsa005651.10068815
39Butanoate metabolism_Homo sapiens_hsa006501.05600426
40RNA degradation_Homo sapiens_hsa030181.04104056
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97799758
42Phototransduction_Homo sapiens_hsa047440.97529313
43Circadian entrainment_Homo sapiens_hsa047130.95616165
44Fanconi anemia pathway_Homo sapiens_hsa034600.92563677
45Propanoate metabolism_Homo sapiens_hsa006400.90483176
46Steroid biosynthesis_Homo sapiens_hsa001000.89717745
47Tryptophan metabolism_Homo sapiens_hsa003800.89311159
48Dopaminergic synapse_Homo sapiens_hsa047280.88906480
49Amphetamine addiction_Homo sapiens_hsa050310.86512113
50Renin secretion_Homo sapiens_hsa049240.84078738
51Long-term potentiation_Homo sapiens_hsa047200.82040817
52Long-term depression_Homo sapiens_hsa047300.78422465
53Base excision repair_Homo sapiens_hsa034100.78329965
54Metabolic pathways_Homo sapiens_hsa011000.78263009
55Nitrogen metabolism_Homo sapiens_hsa009100.77514337
56Tyrosine metabolism_Homo sapiens_hsa003500.76056982
57Salivary secretion_Homo sapiens_hsa049700.75755238
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73027713
59One carbon pool by folate_Homo sapiens_hsa006700.71406210
60Sulfur relay system_Homo sapiens_hsa041220.70229288
61Calcium signaling pathway_Homo sapiens_hsa040200.67837589
62Phenylalanine metabolism_Homo sapiens_hsa003600.65954221
63Rheumatoid arthritis_Homo sapiens_hsa053230.65883102
64RNA transport_Homo sapiens_hsa030130.64740493
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62733060
66Cholinergic synapse_Homo sapiens_hsa047250.61988651
67Olfactory transduction_Homo sapiens_hsa047400.61598074
68Cocaine addiction_Homo sapiens_hsa050300.61111358
69Caffeine metabolism_Homo sapiens_hsa002320.59952431
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59816879
71Gastric acid secretion_Homo sapiens_hsa049710.59519434
72Selenocompound metabolism_Homo sapiens_hsa004500.59324155
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58759506
74Regulation of autophagy_Homo sapiens_hsa041400.58470711
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56567426
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56120536
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.55370845
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54771006
79Axon guidance_Homo sapiens_hsa043600.54077145
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52809639
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51741555
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51376243
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50871116
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.50669495
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50223033
86Glutathione metabolism_Homo sapiens_hsa004800.47960465
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47121568
88Retinol metabolism_Homo sapiens_hsa008300.46984512
89Oxytocin signaling pathway_Homo sapiens_hsa049210.46673260
90Linoleic acid metabolism_Homo sapiens_hsa005910.45893709
91Histidine metabolism_Homo sapiens_hsa003400.45822695
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.44407916
93Gap junction_Homo sapiens_hsa045400.42153943
94Insulin secretion_Homo sapiens_hsa049110.42041087
95Vitamin digestion and absorption_Homo sapiens_hsa049770.41442392
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.39740895
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39076003
98Carbon metabolism_Homo sapiens_hsa012000.38152874
99Arachidonic acid metabolism_Homo sapiens_hsa005900.37803319
100Fatty acid degradation_Homo sapiens_hsa000710.37610229
101Fat digestion and absorption_Homo sapiens_hsa049750.36408717
102Pyrimidine metabolism_Homo sapiens_hsa002400.36325015
103Arginine and proline metabolism_Homo sapiens_hsa003300.36094321
104Dilated cardiomyopathy_Homo sapiens_hsa054140.35708728
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33302668
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32731483
107Non-homologous end-joining_Homo sapiens_hsa034500.30521401
108Sphingolipid metabolism_Homo sapiens_hsa006000.30318219
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30297876
110Alcoholism_Homo sapiens_hsa050340.30161850
111Phagosome_Homo sapiens_hsa041450.30138084
112Purine metabolism_Homo sapiens_hsa002300.29593739
113Pancreatic secretion_Homo sapiens_hsa049720.29564140
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29166605
115Peroxisome_Homo sapiens_hsa041460.27974960
116GnRH signaling pathway_Homo sapiens_hsa049120.27112871
117Melanogenesis_Homo sapiens_hsa049160.27097203
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25764158
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25148276
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25145773
121Systemic lupus erythematosus_Homo sapiens_hsa053220.25049095
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24772086
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24585002
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24302770
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21918551
126Chemical carcinogenesis_Homo sapiens_hsa052040.20329724
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19234283
128Mineral absorption_Homo sapiens_hsa049780.18557210
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18491901
130African trypanosomiasis_Homo sapiens_hsa051430.17682039
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17142391
132Fatty acid metabolism_Homo sapiens_hsa012120.16726925
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13861808
134beta-Alanine metabolism_Homo sapiens_hsa004100.12800746
135cAMP signaling pathway_Homo sapiens_hsa040240.11378159

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