COX7A2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.69129201
2viral transcription (GO:0019083)9.09381423
3translational termination (GO:0006415)8.68488415
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.05656759
5protein targeting to ER (GO:0045047)8.01349710
6cotranslational protein targeting to membrane (GO:0006613)7.89172104
7establishment of protein localization to endoplasmic reticulum (GO:0072599)7.68803071
8translational elongation (GO:0006414)7.62795152
9ribosomal small subunit biogenesis (GO:0042274)7.62387302
10protein localization to endoplasmic reticulum (GO:0070972)7.55134843
11viral life cycle (GO:0019058)6.92996591
12cellular protein complex disassembly (GO:0043624)6.65808845
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.42437235
14translational initiation (GO:0006413)6.06047364
15protein complex disassembly (GO:0043241)5.69732558
16maturation of SSU-rRNA (GO:0030490)5.62384862
17protein targeting to membrane (GO:0006612)5.48037239
18macromolecular complex disassembly (GO:0032984)5.37913632
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.24152753
20ribosomal large subunit biogenesis (GO:0042273)5.21535729
21ATP synthesis coupled proton transport (GO:0015986)5.20890297
22energy coupled proton transport, down electrochemical gradient (GO:0015985)5.20890297
23establishment of protein localization to mitochondrial membrane (GO:0090151)5.18670485
24translation (GO:0006412)4.82102967
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66574640
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.63562469
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.63562469
28oxidative phosphorylation (GO:0006119)4.55857449
29antigen processing and presentation via MHC class Ib (GO:0002475)4.48015469
30chaperone-mediated protein transport (GO:0072321)4.41138218
31nuclear-transcribed mRNA catabolic process (GO:0000956)4.36889137
32* respiratory electron transport chain (GO:0022904)4.29480586
33* electron transport chain (GO:0022900)4.25657190
34mRNA catabolic process (GO:0006402)4.13099536
35antigen processing and presentation of endogenous antigen (GO:0019883)4.10946851
36establishment of protein localization to membrane (GO:0090150)3.84632454
37formation of translation preinitiation complex (GO:0001731)3.75025976
38cytidine metabolic process (GO:0046087)3.74082477
39cytidine catabolic process (GO:0006216)3.74082477
40cytidine deamination (GO:0009972)3.74082477
41cullin deneddylation (GO:0010388)3.71529145
42* hydrogen ion transmembrane transport (GO:1902600)3.68656473
43RNA catabolic process (GO:0006401)3.67814852
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56148572
45regulation of cellular amino acid metabolic process (GO:0006521)3.54769534
46protein targeting (GO:0006605)3.49679141
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48406930
48organelle disassembly (GO:1903008)3.47321372
49termination of RNA polymerase III transcription (GO:0006386)3.45296894
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.45296894
51protein targeting to mitochondrion (GO:0006626)3.41208265
52protein deneddylation (GO:0000338)3.39444192
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38733422
54negative regulation of ligase activity (GO:0051352)3.38733422
55* proton transport (GO:0015992)3.36471740
56ribonucleoprotein complex biogenesis (GO:0022613)3.36126637
57establishment of protein localization to mitochondrion (GO:0072655)3.29785111
58protein localization to mitochondrion (GO:0070585)3.29420580
59* hydrogen transport (GO:0006818)3.29030285
60protein complex biogenesis (GO:0070271)3.27091669
61Golgi transport vesicle coating (GO:0048200)3.27029999
62COPI coating of Golgi vesicle (GO:0048205)3.27029999
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26104312
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24806899
65rRNA modification (GO:0000154)3.24201059
66protein-cofactor linkage (GO:0018065)3.23930175
67ribonucleoprotein complex disassembly (GO:0032988)3.22150368
68establishment of protein localization to organelle (GO:0072594)3.18840019
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17846098
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17715489
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14971128
72endosome to melanosome transport (GO:0035646)3.14500058
73endosome to pigment granule transport (GO:0043485)3.14500058
74water-soluble vitamin biosynthetic process (GO:0042364)3.13930973
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13929928
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13929928
77mitochondrial respiratory chain complex assembly (GO:0033108)3.08779213
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07292913
79cellular component biogenesis (GO:0044085)3.07017744
80respiratory chain complex IV assembly (GO:0008535)3.03803306
81DNA deamination (GO:0045006)3.03068953
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.02229865
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02229865
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01566730
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.99681787
86protein localization to membrane (GO:0072657)2.99422832
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.99296157
88mitochondrial transport (GO:0006839)2.98860894
89intracellular protein transmembrane import (GO:0044743)2.98830494
90positive regulation of ligase activity (GO:0051351)2.98671808
91platelet dense granule organization (GO:0060155)2.97929872
92ATP biosynthetic process (GO:0006754)2.94018271
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93769115
947-methylguanosine mRNA capping (GO:0006370)2.93108661
95establishment of integrated proviral latency (GO:0075713)2.89023966
96ncRNA 3-end processing (GO:0043628)2.88676345
97positive regulation of gamma-delta T cell activation (GO:0046645)2.86745063
98nucleoside triphosphate biosynthetic process (GO:0009142)2.84622693
997-methylguanosine RNA capping (GO:0009452)2.84552765
100RNA capping (GO:0036260)2.84552765
101signal peptide processing (GO:0006465)2.83029091
102DNA damage response, detection of DNA damage (GO:0042769)2.82556301
103cytochrome complex assembly (GO:0017004)2.82242086
104protein neddylation (GO:0045116)2.78925909
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.75991914
106purine nucleoside monophosphate biosynthetic process (GO:0009127)2.75352067
107purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.75352067
108regulation of oxidative phosphorylation (GO:0002082)2.75028216
109negative regulation of erythrocyte differentiation (GO:0045647)2.74842617
110aldehyde catabolic process (GO:0046185)2.74440431
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.73877103
112NADH dehydrogenase complex assembly (GO:0010257)2.73877103
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73877103
114protein K11-linked ubiquitination (GO:0070979)2.73244011
115response to interferon-beta (GO:0035456)2.72264074
116purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72218820
117tricarboxylic acid cycle (GO:0006099)2.69433051
118NADH metabolic process (GO:0006734)2.67143733
119purine nucleoside triphosphate biosynthetic process (GO:0009145)2.65140160
120ribonucleoside triphosphate biosynthetic process (GO:0009201)2.63800046
121aerobic respiration (GO:0009060)2.62936075
122protein maturation by protein folding (GO:0022417)2.62140903
123sequestering of actin monomers (GO:0042989)2.60860783
124oxaloacetate metabolic process (GO:0006107)2.56476179
125negative regulation of glycoprotein biosynthetic process (GO:0010561)2.52110377
126GDP-mannose metabolic process (GO:0019673)2.50486723
127inner mitochondrial membrane organization (GO:0007007)2.50333440
128peptidyl-histidine modification (GO:0018202)2.47516360
129metallo-sulfur cluster assembly (GO:0031163)2.47314858
130iron-sulfur cluster assembly (GO:0016226)2.47314858
131regulation of gamma-delta T cell differentiation (GO:0045586)2.46465906
132heart process (GO:0003015)2.43639368
133heart contraction (GO:0060047)2.43639368
134cellular response to zinc ion (GO:0071294)2.42189106
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.42048081
136antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.41197963
137regulation of mitochondrial translation (GO:0070129)2.40802627
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38184472
139proteasome assembly (GO:0043248)2.33138711
140protein localization to organelle (GO:0033365)2.32955529
141signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.32938309
142intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.32938309
143daunorubicin metabolic process (GO:0044597)2.30387062
144polyketide metabolic process (GO:0030638)2.30387062
145doxorubicin metabolic process (GO:0044598)2.30387062
146signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.28588062
147signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.28588062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90483579
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58397789
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.33549031
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.15402446
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00412078
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.85486215
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.83104378
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78498372
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67573141
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.62475739
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57212314
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50926966
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50017763
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43422128
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.41907502
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.41232734
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35967102
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26856626
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.23431185
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.20064336
21VDR_23849224_ChIP-Seq_CD4+_Human2.17477064
22* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14275580
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13173190
24* XRN2_22483619_ChIP-Seq_HELA_Human2.11260706
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10040478
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09081009
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07676148
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03771888
29ERG_20887958_ChIP-Seq_HPC-7_Mouse1.95990290
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93106496
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92833660
32* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.88583738
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87551912
34DCP1A_22483619_ChIP-Seq_HELA_Human1.85418997
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85086420
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83770438
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83435437
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81388930
39VDR_22108803_ChIP-Seq_LS180_Human1.80565500
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79626041
41FUS_26573619_Chip-Seq_HEK293_Human1.79037097
42MYC_18940864_ChIP-ChIP_HL60_Human1.78678900
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78552262
44* FOXP3_21729870_ChIP-Seq_TREG_Human1.77432128
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75425992
46ZNF274_21170338_ChIP-Seq_K562_Hela1.74237564
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.73384174
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69743911
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68635278
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67961506
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65827575
52MYC_22102868_ChIP-Seq_BL_Human1.64835368
53TTF2_22483619_ChIP-Seq_HELA_Human1.64107711
54SPI1_23547873_ChIP-Seq_NB4_Human1.61857747
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61509801
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.60842708
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59396702
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56688831
59EWS_26573619_Chip-Seq_HEK293_Human1.56488030
60VDR_21846776_ChIP-Seq_THP-1_Human1.55338979
61CIITA_25753668_ChIP-Seq_RAJI_Human1.54746285
62GABP_19822575_ChIP-Seq_HepG2_Human1.53647728
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.52807194
64ELK1_19687146_ChIP-ChIP_HELA_Human1.51897242
65GATA1_22025678_ChIP-Seq_K562_Human1.50958055
66TAF15_26573619_Chip-Seq_HEK293_Human1.45796772
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.45583117
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43536574
69SCL_19346495_ChIP-Seq_HPC-7_Human1.42127670
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40016020
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39912796
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39062158
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37889540
74IGF1R_20145208_ChIP-Seq_DFB_Human1.37836072
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36632114
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35957491
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35318449
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34909317
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.34629366
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34167971
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.32818341
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30948219
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30118539
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28808755
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26508597
86* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24262517
87TP53_22573176_ChIP-Seq_HFKS_Human1.24059040
88* P300_19829295_ChIP-Seq_ESCs_Human1.23350427
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22957144
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22564843
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22150334
92MAF_26560356_Chip-Seq_TH1_Human1.21500284
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20560314
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19333620
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19148483
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18025906
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17761537
98VDR_24763502_ChIP-Seq_THP-1_Human1.17387364
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.16702837
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15941157
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15800253
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15565426
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15493690
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15232685
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.14815416
106UTX_26944678_Chip-Seq_JUKART_Human1.13660889
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13372796
108TFEB_21752829_ChIP-Seq_HELA_Human1.13356675
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11946470
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11860379
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11777219
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09708638
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09532609
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09497634
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08820017
116MYB_26560356_Chip-Seq_TH2_Human1.08098950
117GBX2_23144817_ChIP-Seq_PC3_Human1.07529504
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07378317
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07082141
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.05972223
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05784855
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.04749246
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03538309
124MAF_26560356_Chip-Seq_TH2_Human1.03135267
125HTT_18923047_ChIP-ChIP_STHdh_Human1.01622946
126IRF8_21731497_ChIP-ChIP_J774_Mouse1.01446635
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01227006
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01221551
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00979414
130RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00853160
131RUNX1_22412390_ChIP-Seq_EML_Mouse1.00666466
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00580652
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00403811
134PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00000439
135* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98320908
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98092683
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97464889
138POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95970170
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95686466
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95551627
141RNF2_27304074_Chip-Seq_NSC_Mouse0.95181665
142MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92534467
143ER_23166858_ChIP-Seq_MCF-7_Human0.92138620
144NANOG_19829295_ChIP-Seq_ESCs_Human0.91561559
145SOX2_19829295_ChIP-Seq_ESCs_Human0.91561559
146IRF1_19129219_ChIP-ChIP_H3396_Human0.89867694
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.87713394
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87713394
149EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84777182
150PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82993089
151AR_20517297_ChIP-Seq_VCAP_Human0.82008301
152SALL4_22934838_ChIP-ChIP_CD34+_Human0.81991278
153SOX17_20123909_ChIP-Seq_XEN_Mouse0.81909647
154SALL1_21062744_ChIP-ChIP_HESCs_Human0.79952888
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79917799
156NFE2_27457419_Chip-Seq_LIVER_Mouse0.79193198
157CBX2_27304074_Chip-Seq_ESCs_Mouse0.78126076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.37184695
2MP0000685_abnormal_immune_system2.72028591
3MP0009379_abnormal_foot_pigmentation2.70919221
4MP0003880_abnormal_central_pattern2.67506775
5MP0008877_abnormal_DNA_methylation2.57809088
6MP0002938_white_spotting2.44678865
7MP0005671_abnormal_response_to2.42323927
8MP0001529_abnormal_vocalization2.40659642
9MP0009785_altered_susceptibility_to2.40096339
10MP0006036_abnormal_mitochondrial_physio2.37933203
11MP0002166_altered_tumor_susceptibility2.24505081
12MP0002837_dystrophic_cardiac_calcinosis2.16630580
13MP0003011_delayed_dark_adaptation2.12662436
14MP0003718_maternal_effect2.11880282
15MP0002148_abnormal_hypersensitivity_rea2.10653863
16MP0003763_abnormal_thymus_physiology2.04521888
17MP0002877_abnormal_melanocyte_morpholog2.04207089
18MP0008058_abnormal_DNA_repair2.03695250
19MP0004084_abnormal_cardiac_muscle2.02608992
20MP0003122_maternal_imprinting2.02021674
21MP0003866_abnormal_defecation1.99280500
22MP0003806_abnormal_nucleotide_metabolis1.98301412
23MP0002234_abnormal_pharynx_morphology1.96401952
24MP0002102_abnormal_ear_morphology1.92731991
25MP0010234_abnormal_vibrissa_follicle1.91250560
26MP0005058_abnormal_lysosome_morphology1.90442054
27MP0003436_decreased_susceptibility_to1.88092446
28MP0001984_abnormal_olfaction1.86922564
29MP0005387_immune_system_phenotype1.84157260
30MP0001790_abnormal_immune_system1.84157260
31MP0005000_abnormal_immune_tolerance1.82108826
32MP0001800_abnormal_humoral_immune1.79238031
33MP0009046_muscle_twitch1.78107223
34MP0002693_abnormal_pancreas_physiology1.75070392
35MP0008995_early_reproductive_senescence1.74412281
36MP0005025_abnormal_response_to1.74168835
37MP0009333_abnormal_splenocyte_physiolog1.72790233
38MP0002452_abnormal_antigen_presenting1.69973862
39MP0004808_abnormal_hematopoietic_stem1.69325695
40MP0006292_abnormal_olfactory_placode1.66086041
41MP0002420_abnormal_adaptive_immunity1.65428049
42MP0000566_synostosis1.65320533
43MP0001819_abnormal_immune_cell1.65109873
44MP0006276_abnormal_autonomic_nervous1.64992601
45MP0001905_abnormal_dopamine_level1.63413241
46MP0004142_abnormal_muscle_tone1.61189446
47MP0010155_abnormal_intestine_physiology1.60685573
48MP0002723_abnormal_immune_serum1.60637474
49MP0003136_yellow_coat_color1.59374516
50MP0005253_abnormal_eye_physiology1.56450523
51MP0002006_tumorigenesis1.55587195
52MP0009697_abnormal_copulation1.54122824
53MP0005464_abnormal_platelet_physiology1.53593713
54MP0002398_abnormal_bone_marrow1.51537489
55MP0004147_increased_porphyrin_level1.50322358
56MP0008789_abnormal_olfactory_epithelium1.49622368
57MP0005645_abnormal_hypothalamus_physiol1.49281029
58MP0005551_abnormal_eye_electrophysiolog1.49037019
59MP0001944_abnormal_pancreas_morphology1.48979882
60MP0003121_genomic_imprinting1.48381106
61MP0006054_spinal_hemorrhage1.45800802
62MP0010386_abnormal_urinary_bladder1.45553986
63MP0001188_hyperpigmentation1.42720521
64MP0005084_abnormal_gallbladder_morpholo1.41974238
65MP0003283_abnormal_digestive_organ1.40919298
66MP0003186_abnormal_redox_activity1.40654360
67MP0003724_increased_susceptibility_to1.38742401
68MP0000716_abnormal_immune_system1.37822209
69MP0001853_heart_inflammation1.37619511
70MP0004036_abnormal_muscle_relaxation1.35634327
71MP0001845_abnormal_inflammatory_respons1.35143616
72MP0003300_gastrointestinal_ulcer1.34216416
73MP0002138_abnormal_hepatobiliary_system1.33672852
74MP0002396_abnormal_hematopoietic_system1.33618079
75MP0002722_abnormal_immune_system1.33358015
76MP0002638_abnormal_pupillary_reflex1.32850231
77MP0002751_abnormal_autonomic_nervous1.32473765
78MP0000631_abnormal_neuroendocrine_gland1.31128526
79MP0000689_abnormal_spleen_morphology1.31002369
80MP0000490_abnormal_crypts_of1.30990317
81MP0004947_skin_inflammation1.29680349
82MP0002429_abnormal_blood_cell1.26326761
83MP0009643_abnormal_urine_homeostasis1.26081972
84MP0002160_abnormal_reproductive_system1.25851555
85MP0002736_abnormal_nociception_after1.25410497
86MP0005310_abnormal_salivary_gland1.24773236
87MP0003786_premature_aging1.23453216
88MP0009745_abnormal_behavioral_response1.23372078
89MP0002405_respiratory_system_inflammati1.22853821
90MP0002272_abnormal_nervous_system1.21417769
91MP0001986_abnormal_taste_sensitivity1.21312040
92MP0000358_abnormal_cell_content/1.20408850
93MP0003693_abnormal_embryo_hatching1.20287270
94MP0005394_taste/olfaction_phenotype1.20209779
95MP0005499_abnormal_olfactory_system1.20209779
96MP0000013_abnormal_adipose_tissue1.19129742
97MP0003195_calcinosis1.18405129
98MP0002734_abnormal_mechanical_nocicepti1.17969277
99MP0001968_abnormal_touch/_nociception1.17937732
100MP0003787_abnormal_imprinting1.16583040
101MP0000465_gastrointestinal_hemorrhage1.16451222
102MP0002090_abnormal_vision1.16330910
103MP0005636_abnormal_mineral_homeostasis1.15686203
104MP0001293_anophthalmia1.15311299
105MP0002419_abnormal_innate_immunity1.14549041
106MP0004133_heterotaxia1.13274737
107MP0008875_abnormal_xenobiotic_pharmacok1.12781469
108MP0001873_stomach_inflammation1.12738412
109MP0000750_abnormal_muscle_regeneration1.12700495
110MP0005220_abnormal_exocrine_pancreas1.12583326
111MP0005408_hypopigmentation1.10404675
112MP0006035_abnormal_mitochondrial_morpho1.08533558
113MP0003890_abnormal_embryonic-extraembry1.08453953
114MP0010030_abnormal_orbit_morphology1.08081237
115MP0000703_abnormal_thymus_morphology1.07950093
116MP0002210_abnormal_sex_determination1.07524753
117MP0008872_abnormal_physiological_respon1.07414825
118MP0008469_abnormal_protein_level1.05708982
119MP0005174_abnormal_tail_pigmentation1.05221854
120MP0002132_abnormal_respiratory_system1.04903054
121MP0000372_irregular_coat_pigmentation1.04645494
122MP0004270_analgesia1.04402073
123MP0001879_abnormal_lymphatic_vessel1.02229845
124MP0010352_gastrointestinal_tract_polyps1.02094015
125MP0005379_endocrine/exocrine_gland_phen1.01355283
126MP0005332_abnormal_amino_acid1.01138222
127MP0002095_abnormal_skin_pigmentation1.00595804
128MP0000343_altered_response_to1.00396888
129MP0002277_abnormal_respiratory_mucosa1.00161419
130MP0003646_muscle_fatigue0.99997130
131MP0003567_abnormal_fetal_cardiomyocyte0.98878660
132MP0005075_abnormal_melanosome_morpholog0.98285099
133MP0001486_abnormal_startle_reflex0.98227462
134MP0008932_abnormal_embryonic_tissue0.95910866
135MP0001764_abnormal_homeostasis0.95757027
136MP0002163_abnormal_gland_morphology0.95589659
137MP0001756_abnormal_urination0.95383313
138MP0002009_preneoplasia0.94802339
139MP0005646_abnormal_pituitary_gland0.94357651
140MP0000678_abnormal_parathyroid_gland0.94254000
141MP0003828_pulmonary_edema0.93880096
142MP0002064_seizures0.92836267
143MP0004043_abnormal_pH_regulation0.92516317
144MP0006072_abnormal_retinal_apoptosis0.92493702
145MP0002139_abnormal_hepatobiliary_system0.91736789
146MP0000858_altered_metastatic_potential0.91732996
147MP0002876_abnormal_thyroid_physiology0.91544323
148MP0004957_abnormal_blastocyst_morpholog0.91255031
149MP0001929_abnormal_gametogenesis0.91117133
150MP0005330_cardiomyopathy0.90461882
151MP0001485_abnormal_pinna_reflex0.89250797
152MP0000653_abnormal_sex_gland0.89040327
153MP0003938_abnormal_ear_development0.88709143
154MP0000647_abnormal_sebaceous_gland0.88312699
155MP0002233_abnormal_nose_morphology0.87210885
156MP0005389_reproductive_system_phenotype0.87023546
157MP0000569_abnormal_digit_pigmentation0.86843769
158MP0001145_abnormal_male_reproductive0.86518203
159MP0001324_abnormal_eye_pigmentation0.85701082
160MP0001666_abnormal_nutrient_absorption0.85645527
161MP0002078_abnormal_glucose_homeostasis0.85534059
162MP0003937_abnormal_limbs/digits/tail_de0.85463293
163MP0000749_muscle_degeneration0.84993017
164MP0004510_myositis0.84687947
165MP0002184_abnormal_innervation0.84539825
166MP0004019_abnormal_vitamin_homeostasis0.83242213
167MP0001545_abnormal_hematopoietic_system0.82920532
168MP0005397_hematopoietic_system_phenotyp0.82920532
169MP0002909_abnormal_adrenal_gland0.82783315
170MP0002572_abnormal_emotion/affect_behav0.82529987
171MP0001765_abnormal_ion_homeostasis0.82400017
172MP0004130_abnormal_muscle_cell0.82005892
173MP0005367_renal/urinary_system_phenotyp0.81376877
174MP0000516_abnormal_urinary_system0.81376877
175MP0000613_abnormal_salivary_gland0.80936984
176MP0005385_cardiovascular_system_phenoty0.80776710
177MP0001544_abnormal_cardiovascular_syste0.80776710
178MP0005410_abnormal_fertilization0.80514900
179MP0002735_abnormal_chemical_nociception0.80034208

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.44200552
2Abnormal number of erythroid precursors (HP:0012131)5.41572742
3Acute necrotizing encephalopathy (HP:0006965)4.55137309
4Abnormal mitochondria in muscle tissue (HP:0008316)4.53402390
5Hepatic necrosis (HP:0002605)4.44679045
6Hepatocellular necrosis (HP:0001404)4.33508890
7Mitochondrial inheritance (HP:0001427)4.31324257
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.11887036
9Decreased activity of mitochondrial respiratory chain (HP:0008972)4.11887036
10Reticulocytopenia (HP:0001896)3.95566337
11Acute encephalopathy (HP:0006846)3.85336565
12Increased CSF lactate (HP:0002490)3.74539543
13Progressive macrocephaly (HP:0004481)3.72156871
14Macrocytic anemia (HP:0001972)3.55935497
15Thrombocytosis (HP:0001894)3.54870310
16Pallor (HP:0000980)3.51570282
17Microvesicular hepatic steatosis (HP:0001414)3.31766232
18Lactic acidosis (HP:0003128)3.14171371
19Increased muscle lipid content (HP:0009058)3.13197249
20Increased intramyocellular lipid droplets (HP:0012240)3.12100547
21Generalized aminoaciduria (HP:0002909)3.07278880
22Exercise intolerance (HP:0003546)3.04778731
23Methylmalonic acidemia (HP:0002912)3.04496548
24Cerebral edema (HP:0002181)3.02070375
25Abnormal hemoglobin (HP:0011902)3.01887206
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93883474
27Lipid accumulation in hepatocytes (HP:0006561)2.91012126
28Methylmalonic aciduria (HP:0012120)2.88029703
29Increased hepatocellular lipid droplets (HP:0006565)2.87429366
30Congenital, generalized hypertrichosis (HP:0004540)2.84796913
31Palpitations (HP:0001962)2.73869956
32Pancreatic cysts (HP:0001737)2.69858265
33Respiratory failure (HP:0002878)2.68731119
34Optic disc pallor (HP:0000543)2.64168434
35Hypoglycemic coma (HP:0001325)2.62957767
36Petechiae (HP:0000967)2.61614406
37Abnormality of the labia minora (HP:0012880)2.60666617
38Exertional dyspnea (HP:0002875)2.60567876
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59428742
40Dicarboxylic aciduria (HP:0003215)2.59428742
41Ragged-red muscle fibers (HP:0003200)2.58396000
42Abnormality of methionine metabolism (HP:0010901)2.55296257
43Aplastic anemia (HP:0001915)2.55156105
44Medial flaring of the eyebrow (HP:0010747)2.54331622
45Vacuolated lymphocytes (HP:0001922)2.53752409
46Pancreatic fibrosis (HP:0100732)2.51912671
47Hypothermia (HP:0002045)2.48798043
48Lethargy (HP:0001254)2.43751611
49Conjunctival hamartoma (HP:0100780)2.43461595
50Leukodystrophy (HP:0002415)2.43117820
51Abnormality of renal resorption (HP:0011038)2.41796518
52Myoglobinuria (HP:0002913)2.40816982
53Renal cortical cysts (HP:0000803)2.40319063
54Neoplasm of head and neck (HP:0012288)2.39474726
55Esophageal neoplasm (HP:0100751)2.39474726
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39332797
57Progressive muscle weakness (HP:0003323)2.38509463
58Increased serum lactate (HP:0002151)2.37768325
59Asymmetric septal hypertrophy (HP:0001670)2.36150485
60Poor suck (HP:0002033)2.35089383
61True hermaphroditism (HP:0010459)2.34773534
62Elevated erythrocyte sedimentation rate (HP:0003565)2.33437328
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31798606
64IgM deficiency (HP:0002850)2.23430466
65Hyperglycinemia (HP:0002154)2.22791449
66Abnormality of the nasal mucosa (HP:0000433)2.20603591
67Increased serum pyruvate (HP:0003542)2.19515170
68Multiple enchondromatosis (HP:0005701)2.18656852
69CNS demyelination (HP:0007305)2.17733061
70Myokymia (HP:0002411)2.17717333
71Molar tooth sign on MRI (HP:0002419)2.16007971
72Abnormality of midbrain morphology (HP:0002418)2.16007971
73Renal Fanconi syndrome (HP:0001994)2.15660878
74Nasal polyposis (HP:0100582)2.14034932
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12233957
76Congenital primary aphakia (HP:0007707)2.10880659
77Gait imbalance (HP:0002141)2.09633052
78Degeneration of anterior horn cells (HP:0002398)2.08388045
79Abnormality of the anterior horn cell (HP:0006802)2.08388045
80Abnormality of glycolysis (HP:0004366)2.06676021
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04910990
82Recurrent bronchitis (HP:0002837)2.04673318
83Nephronophthisis (HP:0000090)2.04506428
84Chronic otitis media (HP:0000389)2.03420147
85Abnormality of serum amino acid levels (HP:0003112)2.00577308
86X-linked dominant inheritance (HP:0001423)1.99359638
87Hyperalaninemia (HP:0003348)1.97394407
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97394407
89Abnormality of alanine metabolism (HP:0010916)1.97394407
90Respiratory difficulties (HP:0002880)1.97055005
91Abnormality of vitamin B metabolism (HP:0004340)1.97022165
92Nephrogenic diabetes insipidus (HP:0009806)1.96856034
93Interstitial pulmonary disease (HP:0006530)1.95474538
94Ventricular tachycardia (HP:0004756)1.94733926
95Hyperinsulinemic hypoglycemia (HP:0000825)1.94362561
96Late onset (HP:0003584)1.94189715
97Oligomenorrhea (HP:0000876)1.93445038
98Abnormality of the renal cortex (HP:0011035)1.93054952
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.92204505
100Neuroendocrine neoplasm (HP:0100634)1.91892080
101Limb dystonia (HP:0002451)1.91419664
102Rhabdomyolysis (HP:0003201)1.90876113
103Cerebral hypomyelination (HP:0006808)1.90316347
104Myositis (HP:0100614)1.88392897
105Symptomatic seizures (HP:0011145)1.87945972
106Ketoacidosis (HP:0001993)1.87100392
107Proximal tubulopathy (HP:0000114)1.86460142
108Abnormality of T cell physiology (HP:0011840)1.83797833
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.83437837
110Oral leukoplakia (HP:0002745)1.82335784
111Type I transferrin isoform profile (HP:0003642)1.81906272
112Glycosuria (HP:0003076)1.81501878
113Abnormality of urine glucose concentration (HP:0011016)1.81501878
114Concave nail (HP:0001598)1.79898460
115Stenosis of the external auditory canal (HP:0000402)1.77092612
116Genital tract atresia (HP:0001827)1.76640586
117Gastrointestinal stroma tumor (HP:0100723)1.76524646
118Hyperphosphaturia (HP:0003109)1.76334867
119Hypoglycemic seizures (HP:0002173)1.76183075
120Growth hormone excess (HP:0000845)1.76163444
121Hypoproteinemia (HP:0003075)1.74699025
122Abnormality of fatty-acid metabolism (HP:0004359)1.74486011
1233-Methylglutaconic aciduria (HP:0003535)1.74050193
124Dysostosis multiplex (HP:0000943)1.73876432
125Neoplasm of the adrenal gland (HP:0100631)1.73749731
126Panhypogammaglobulinemia (HP:0003139)1.73240035
127Chronic sinusitis (HP:0011109)1.72897114
128Emotional lability (HP:0000712)1.72867861
129Reduced antithrombin III activity (HP:0001976)1.72340222
130Vaginal atresia (HP:0000148)1.72150485
131Colon cancer (HP:0003003)1.71766118
132Abnormality of the vitamin B12 metabolism (HP:0004341)1.70947611
133Dilated cardiomyopathy (HP:0001644)1.68771569
134CNS hypomyelination (HP:0003429)1.68690061
135Increased cerebral lipofuscin (HP:0011813)1.68581253
136Muscular hypotonia of the trunk (HP:0008936)1.67866658
137Abnormal protein glycosylation (HP:0012346)1.66643783
138Abnormal glycosylation (HP:0012345)1.66643783
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66643783
140Abnormal protein N-linked glycosylation (HP:0012347)1.66643783
141Abnormality of T cells (HP:0002843)1.66480523
142Bone cyst (HP:0012062)1.66269290
143Muscle fiber atrophy (HP:0100295)1.66222663
144Abnormality of B cell number (HP:0010975)1.66189012
145B lymphocytopenia (HP:0010976)1.66189012
146Posterior subcapsular cataract (HP:0007787)1.66118577
147Recurrent abscess formation (HP:0002722)1.66105062
148Papilloma (HP:0012740)1.65927887
149Verrucae (HP:0200043)1.65927887
150Urinary glycosaminoglycan excretion (HP:0003541)1.64569963
151Mucopolysacchariduria (HP:0008155)1.64569963
152Supernumerary spleens (HP:0009799)1.64513477
153Short tibia (HP:0005736)1.63460534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.01292499
2TAOK34.38705730
3VRK23.13166243
4FLT32.56207761
5TGFBR12.54063442
6PASK2.47377312
7TRIM282.31991285
8ZAK2.29073201
9RPS6KB22.24418742
10MAP4K12.22746537
11SRPK12.22217061
12MYLK2.06044561
13MAPKAPK32.02308078
14WNK31.98512986
15MAP4K21.96769726
16PIM21.95388941
17ERN11.86950502
18LRRK21.86259332
19ZAP701.85924885
20PKN21.84223745
21ARAF1.77927806
22BCKDK1.77395110
23ILK1.74185138
24CDK191.72046223
25MAP3K121.70194622
26EEF2K1.69013602
27MST41.67758327
28TBK11.63412196
29NEK11.59041963
30PLK31.55849284
31EIF2AK31.51556011
32TYK21.51203022
33TEC1.51105019
34DYRK21.48018233
35MAP3K41.47209361
36PINK11.45754911
37BTK1.45392000
38PBK1.45036841
39TRIB31.41553630
40CASK1.40064962
41KIT1.38587906
42FRK1.37017266
43TLK11.36613665
44BCR1.34653374
45STK161.33821752
46GRK11.30659064
47PLK21.28004469
48IKBKE1.22642844
49MAP2K21.22592973
50STK241.22558466
51PDK21.22275052
52CSNK1G31.21570979
53OXSR11.19228579
54NUAK11.15313571
55CSNK1G11.13421093
56TGFBR21.11957446
57SYK1.11204412
58MAP3K31.09080977
59CSNK1G21.08526420
60NLK1.08342513
61MAP2K31.07929205
62JAK31.06892848
63IKBKB1.06514546
64MAP2K71.05189197
65MAPK151.00566193
66MUSK1.00203428
67CDC70.99065217
68LIMK10.98104129
69EPHB20.97656740
70EIF2AK10.96537890
71BUB10.94644599
72ERBB30.93603308
73TIE10.92460966
74TTK0.92161266
75FGFR20.91385536
76ITK0.91281489
77EPHA40.91149299
78PHKG20.90594517
79PHKG10.90594517
80PLK40.90584969
81BLK0.89545336
82CSNK1A1L0.88509804
83DYRK30.88016271
84MINK10.87914544
85PIK3CG0.87205545
86TXK0.86602866
87BMPR1B0.86138157
88FGFR40.83833172
89PRKCG0.82722618
90PNCK0.82300884
91PLK10.82177103
92IRAK40.80973451
93NEK90.80552034
94CDK80.80361888
95RPS6KA40.79987952
96PRKG20.79974474
97LMTK20.79965600
98MAP3K20.78373061
99BRSK20.78277315
100TNIK0.76351240
101HIPK20.76312285
102STK38L0.74692597
103RPS6KA50.74523420
104ADRBK20.73827674
105MAP3K140.72344518
106INSRR0.72273926
107MAP3K110.72092814
108NME10.71513101
109PRKCE0.71431724
110MKNK10.71097722
111RPS6KA60.70612420
112MAP3K100.70058918
113RPS6KL10.69577321
114RPS6KC10.69577321
115CSF1R0.69363072
116GRK60.68288922
117PAK30.68051455
118MAPKAPK50.65219233
119TTN0.65091780
120MARK10.64954864
121CSNK2A20.64954568
122TESK10.64503542
123IRAK10.64239616
124TSSK60.63863573
125GRK70.63574008
126VRK10.63531894
127PIM10.62236816
128CSNK2A10.62220259
129DAPK30.59377768
130STK390.58847741
131IRAK30.57678155
132MATK0.54872128
133ACVR1B0.54680512
134AURKB0.53237511
135LCK0.52968878
136WNK40.51833524
137MAP3K130.51828179
138PDK40.51021988
139PDK30.51021988
140MAP3K10.49987619
141SCYL20.49707518
142STK40.49543569
143KDR0.48651482
144MAPKAPK20.48030185
145MAPK130.47388173
146TAF10.46090176
147CCNB10.45333226
148CAMK2A0.44965702
149MOS0.44809981
150BRAF0.44662299
151CSNK1E0.44411873
152CAMKK20.43821669
153DAPK10.43764444
154AURKA0.43727848
155TNK20.43684829
156CDK140.43256068
157MAP2K60.42518270
158WEE10.42360237
159CAMK2D0.41879568
160RIPK10.41290027
161MKNK20.39853588
162STK30.39447500
163NTRK30.39076680
164CSNK1A10.38110734
165LYN0.37486541
166CLK10.37435418
167JAK20.37082519
168PRKACA0.36579380
169PRKCI0.36528738
170GRK50.36383186

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.28045513
2* Oxidative phosphorylation_Homo sapiens_hsa001904.18910215
3Parkinsons disease_Homo sapiens_hsa050123.93166922
4Protein export_Homo sapiens_hsa030603.53080384
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.21044425
6Proteasome_Homo sapiens_hsa030502.94562962
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.74380261
8Alzheimers disease_Homo sapiens_hsa050102.59600360
9Huntingtons disease_Homo sapiens_hsa050162.41405998
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.15157581
11Sulfur metabolism_Homo sapiens_hsa009202.02528816
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70623069
13Primary immunodeficiency_Homo sapiens_hsa053401.63506828
14Basal transcription factors_Homo sapiens_hsa030221.62581026
15RNA polymerase_Homo sapiens_hsa030201.62474148
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54840727
17Homologous recombination_Homo sapiens_hsa034401.52057626
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45950035
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43128063
20Fatty acid elongation_Homo sapiens_hsa000621.33649779
21Antigen processing and presentation_Homo sapiens_hsa046121.27819512
22Legionellosis_Homo sapiens_hsa051341.26397573
23* Cardiac muscle contraction_Homo sapiens_hsa042601.24284493
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23514069
25Sulfur relay system_Homo sapiens_hsa041221.22890365
26One carbon pool by folate_Homo sapiens_hsa006701.22236223
27Other glycan degradation_Homo sapiens_hsa005111.22135984
28Pyrimidine metabolism_Homo sapiens_hsa002401.19751444
29Phototransduction_Homo sapiens_hsa047441.15486318
30Galactose metabolism_Homo sapiens_hsa000521.14026338
31RNA transport_Homo sapiens_hsa030131.12455424
32Butanoate metabolism_Homo sapiens_hsa006501.11489061
33Vibrio cholerae infection_Homo sapiens_hsa051101.11135582
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09477656
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08146364
36Glutathione metabolism_Homo sapiens_hsa004801.03765367
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03426176
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99269792
39Carbon metabolism_Homo sapiens_hsa012000.99143045
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.91894453
41Folate biosynthesis_Homo sapiens_hsa007900.90747531
42Peroxisome_Homo sapiens_hsa041460.90234196
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88215737
44Steroid biosynthesis_Homo sapiens_hsa001000.88079413
45Leishmaniasis_Homo sapiens_hsa051400.87728344
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.87682900
47N-Glycan biosynthesis_Homo sapiens_hsa005100.86953499
48Fanconi anemia pathway_Homo sapiens_hsa034600.85983477
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85569530
50Fructose and mannose metabolism_Homo sapiens_hsa000510.83379651
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81947053
52Nicotine addiction_Homo sapiens_hsa050330.79445087
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78109376
54Acute myeloid leukemia_Homo sapiens_hsa052210.77400328
55Measles_Homo sapiens_hsa051620.77047726
56Mismatch repair_Homo sapiens_hsa034300.75300139
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.74294065
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74091997
59Propanoate metabolism_Homo sapiens_hsa006400.73964064
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73901860
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73741456
62Regulation of autophagy_Homo sapiens_hsa041400.72905345
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.72738813
64Lysosome_Homo sapiens_hsa041420.72707288
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72666147
66Chemical carcinogenesis_Homo sapiens_hsa052040.72161762
67Base excision repair_Homo sapiens_hsa034100.71078879
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70828559
69Synaptic vesicle cycle_Homo sapiens_hsa047210.70566078
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69167934
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69146576
72Tryptophan metabolism_Homo sapiens_hsa003800.68225850
73B cell receptor signaling pathway_Homo sapiens_hsa046620.67848385
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67714927
75DNA replication_Homo sapiens_hsa030300.66812563
76Hematopoietic cell lineage_Homo sapiens_hsa046400.66401091
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65769061
78Nitrogen metabolism_Homo sapiens_hsa009100.65005751
79Fatty acid degradation_Homo sapiens_hsa000710.61860986
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.61220213
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61081272
82Thyroid cancer_Homo sapiens_hsa052160.60133640
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.59506796
84Type I diabetes mellitus_Homo sapiens_hsa049400.59264030
85Herpes simplex infection_Homo sapiens_hsa051680.59117190
86Apoptosis_Homo sapiens_hsa042100.58415158
87Retinol metabolism_Homo sapiens_hsa008300.57660813
88Rheumatoid arthritis_Homo sapiens_hsa053230.57030438
89Pyruvate metabolism_Homo sapiens_hsa006200.56865114
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55847309
91Oocyte meiosis_Homo sapiens_hsa041140.55622361
92Pentose phosphate pathway_Homo sapiens_hsa000300.55492019
93beta-Alanine metabolism_Homo sapiens_hsa004100.54013474
94Epstein-Barr virus infection_Homo sapiens_hsa051690.53553947
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.52842663
96Spliceosome_Homo sapiens_hsa030400.51897692
97Toxoplasmosis_Homo sapiens_hsa051450.51791723
98Collecting duct acid secretion_Homo sapiens_hsa049660.50483819
99Prolactin signaling pathway_Homo sapiens_hsa049170.50235190
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48860596
101Osteoclast differentiation_Homo sapiens_hsa043800.47813872
102Metabolic pathways_Homo sapiens_hsa011000.47513146
103Tyrosine metabolism_Homo sapiens_hsa003500.47501018
104Allograft rejection_Homo sapiens_hsa053300.47484931
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47344466
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47006386
107Pertussis_Homo sapiens_hsa051330.46332055
108Vitamin B6 metabolism_Homo sapiens_hsa007500.46063109
109Purine metabolism_Homo sapiens_hsa002300.45850143
110Nucleotide excision repair_Homo sapiens_hsa034200.44491707
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41486643
112Arginine and proline metabolism_Homo sapiens_hsa003300.39828285
113p53 signaling pathway_Homo sapiens_hsa041150.39783466
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39500665
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39104179
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38918333
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38828278
118HIF-1 signaling pathway_Homo sapiens_hsa040660.38602716
119GABAergic synapse_Homo sapiens_hsa047270.36741446
120T cell receptor signaling pathway_Homo sapiens_hsa046600.36511902
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35977168
122Mineral absorption_Homo sapiens_hsa049780.35276791
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.35137821
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34612874
125Fatty acid metabolism_Homo sapiens_hsa012120.34561491
126Biosynthesis of amino acids_Homo sapiens_hsa012300.34373186
127Chronic myeloid leukemia_Homo sapiens_hsa052200.34226435
128Phagosome_Homo sapiens_hsa041450.34186159
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34016038
130Circadian rhythm_Homo sapiens_hsa047100.33548891
131RNA degradation_Homo sapiens_hsa030180.33429726
132Influenza A_Homo sapiens_hsa051640.32853211
133Cell cycle_Homo sapiens_hsa041100.32025590
134Phenylalanine metabolism_Homo sapiens_hsa003600.31518563
135Graft-versus-host disease_Homo sapiens_hsa053320.31238714
136Taste transduction_Homo sapiens_hsa047420.30534203
137Arachidonic acid metabolism_Homo sapiens_hsa005900.30019786
138Tuberculosis_Homo sapiens_hsa051520.29447562
139Shigellosis_Homo sapiens_hsa051310.29026812
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28414414
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28114872
142Hepatitis B_Homo sapiens_hsa051610.27110250
143Insulin signaling pathway_Homo sapiens_hsa049100.26987830
144Selenocompound metabolism_Homo sapiens_hsa004500.26480876
145mRNA surveillance pathway_Homo sapiens_hsa030150.26066367
146Caffeine metabolism_Homo sapiens_hsa002320.25538736
147Non-homologous end-joining_Homo sapiens_hsa034500.25280544
148TNF signaling pathway_Homo sapiens_hsa046680.25092081
149Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24588315
150Olfactory transduction_Homo sapiens_hsa047400.23929756
151Alcoholism_Homo sapiens_hsa050340.23809363
152Vitamin digestion and absorption_Homo sapiens_hsa049770.23805771
153Linoleic acid metabolism_Homo sapiens_hsa005910.23039192

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