ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	5.54138300
2	protein deneddylation (GO:0000338)	5.46605869
3	protein neddylation (GO:0045116)	5.20770902
4	nucleotide transmembrane transport (GO:1901679)	4.26964923
5	regulation of meiosis I (GO:0060631)	4.06148635
6	DNA methylation involved in gamete generation (GO:0043046)	3.91525037
7	cullin deneddylation (GO:0010388)	3.84027052
8	inositol phosphate catabolic process (GO:0071545)	3.81119352
9	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.77233896
10	protein polyglutamylation (GO:0018095)	3.74951936
11	centriole replication (GO:0007099)	3.74638729
12	inositol phosphate dephosphorylation (GO:0046855)	3.71036596
13	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.71036596
14	mismatch repair (GO:0006298)	3.65308229
15	prenylation (GO:0097354)	3.56140785
16	protein prenylation (GO:0018342)	3.56140785
17	adenosine metabolic process (GO:0046085)	3.53987954
18	one-carbon compound transport (GO:0019755)	3.53972386
19	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.52394236
20	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.47315487
21	negative regulation of osteoblast proliferation (GO:0033689)	3.33050703
22	negative regulation of appetite (GO:0032099)	3.32376820
23	negative regulation of response to food (GO:0032096)	3.32376820
24	polyol catabolic process (GO:0046174)	3.30421782
25	fusion of sperm to egg plasma membrane (GO:0007342)	3.25753904
26	erythrocyte maturation (GO:0043249)	3.25544849
27	male meiosis (GO:0007140)	3.21588140
28	response to misfolded protein (GO:0051788)	3.18851826
29	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.16658782
30	meiotic cell cycle (GO:0051321)	3.16104345
31	protein K48-linked ubiquitination (GO:0070936)	3.13876380
32	regulation of female gonad development (GO:2000194)	3.12393283
33	positive regulation of endothelial cell differentiation (GO:0045603)	3.12065093
34	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.10974110
35	regulation of response to osmotic stress (GO:0047484)	3.09609822
36	hemoglobin metabolic process (GO:0020027)	3.09294756
37	negative regulation of heart rate (GO:0010459)	3.09195836
38	base-excision repair, AP site formation (GO:0006285)	3.02678515
39	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.96744133
40	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.96744133
41	pyrimidine dimer repair (GO:0006290)	2.93561269
42	phosphorelay signal transduction system (GO:0000160)	2.90945594
43	positive regulation of Rho protein signal transduction (GO:0035025)	2.90274370
44	positive regulation of hormone biosynthetic process (GO:0046886)	2.90264414
45	binding of sperm to zona pellucida (GO:0007339)	2.90004313
46	relaxation of smooth muscle (GO:0044557)	2.88116229
47	developmental pigmentation (GO:0048066)	2.87986255
48	tyrosine metabolic process (GO:0006570)	2.87625695
49	auditory receptor cell differentiation (GO:0042491)	2.87074640
50	regulation of coenzyme metabolic process (GO:0051196)	2.85368519
51	regulation of cofactor metabolic process (GO:0051193)	2.85368519
52	regulation of steroid hormone secretion (GO:2000831)	2.83832238
53	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.83275107
54	negative regulation of norepinephrine secretion (GO:0010700)	2.82853121
55	amino acid salvage (GO:0043102)	2.81668970
56	L-methionine salvage (GO:0071267)	2.81668970
57	L-methionine biosynthetic process (GO:0071265)	2.81668970
58	ketone body metabolic process (GO:1902224)	2.80508412
59	plasma membrane fusion (GO:0045026)	2.80050167
60	synapsis (GO:0007129)	2.79451523
61	regulation of DNA methylation (GO:0044030)	2.77688945
62	signal peptide processing (GO:0006465)	2.77282050
63	methionine metabolic process (GO:0006555)	2.76275483
64	thrombin receptor signaling pathway (GO:0070493)	2.75112622
65	serotonin receptor signaling pathway (GO:0007210)	2.73491406
66	very long-chain fatty acid metabolic process (GO:0000038)	2.72399236
67	sleep (GO:0030431)	2.71404837
68	sperm-egg recognition (GO:0035036)	2.70426027
69	negative regulation of cation channel activity (GO:2001258)	2.69817105
70	oocyte development (GO:0048599)	2.69402848
71	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.69136253
72	cellular ketone body metabolic process (GO:0046950)	2.69009849
73	platelet dense granule organization (GO:0060155)	2.68634675
74	regulation of germinal center formation (GO:0002634)	2.66290985
75	positive regulation of protein homodimerization activity (GO:0090073)	2.65735996
76	neurotransmitter-gated ion channel clustering (GO:0072578)	2.65718172
77	purine deoxyribonucleotide catabolic process (GO:0009155)	2.64611393
78	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.64249321
79	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.64245725
80	lipoxygenase pathway (GO:0019372)	2.63240108
81	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.62803233
82	gene silencing by RNA (GO:0031047)	2.61239919
83	female gamete generation (GO:0007292)	2.61107305
84	ribonucleoprotein complex disassembly (GO:0032988)	2.60612447
85	fatty acid elongation (GO:0030497)	2.60297816
86	multicellular organism reproduction (GO:0032504)	2.60004038
87	regulation of vacuole organization (GO:0044088)	2.59281400
88	mitochondrial calcium ion transport (GO:0006851)	2.58678736
89	acrosome assembly (GO:0001675)	2.58311700
90	regulation of female receptivity (GO:0045924)	2.58199292
91	female gonad development (GO:0008585)	2.52836483
92	neuron fate determination (GO:0048664)	2.51322167
93	oxidative demethylation (GO:0070989)	2.50700588
94	peptidyl-glutamic acid modification (GO:0018200)	2.50654092
95	organelle disassembly (GO:1903008)	2.49548357
96	deoxyribose phosphate catabolic process (GO:0046386)	2.49089701
97	regulation of male gonad development (GO:2000018)	2.48776000
98	centriole assembly (GO:0098534)	2.48418304
99	regulation of memory T cell differentiation (GO:0043380)	2.45104029
100	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.43137694

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.27726744
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.33097245
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.27626831
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.24797437
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.23106832
6	IRF1_19129219_ChIP-ChIP_H3396_Human	3.17017914
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.14422387
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.81674363
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.70945634
10	HTT_18923047_ChIP-ChIP_STHdh_Human	2.26636484
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15544293
12	EWS_26573619_Chip-Seq_HEK293_Human	2.03392315
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01939254
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95867284
15	FUS_26573619_Chip-Seq_HEK293_Human	1.94636220
16	CBP_20019798_ChIP-Seq_JUKART_Human	1.83838046
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.83838046
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.82745302
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.82565856
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80313092
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.75908098
22	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.75332695
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69322561
24	AR_25329375_ChIP-Seq_VCAP_Human	1.66297738
25	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.64939240
26	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.64823754
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.64345886
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63405840
29	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61048940
30	P300_19829295_ChIP-Seq_ESCs_Human	1.57913793
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57587353
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54653649
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53097587
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53014874
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52939607
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.52453040
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48466139
38	VDR_22108803_ChIP-Seq_LS180_Human	1.48358704
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.47806507
40	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.45877337
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.44773305
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41890133
43	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.40975705
44	STAT3_23295773_ChIP-Seq_U87_Human	1.40592649
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40337899
46	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40075345
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40044688
48	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.37866381
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32143011
50	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.30720135
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29716045
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28817940
53	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.28137819
54	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27191475
55	TCF4_23295773_ChIP-Seq_U87_Human	1.24820285
56	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.24703810
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.24212373
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20311373
59	JUN_21703547_ChIP-Seq_K562_Human	1.19497286
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16277710
61	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.15307209
62	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12638427
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11118300
64	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10909736
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10662451
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10328462
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10328462
68	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.09486185
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.09331783
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08739698
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08705638
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08366421
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08021666
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08021666
75	GATA3_26560356_Chip-Seq_TH1_Human	1.07369610
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.07158827
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05185703
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04944494
79	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.04395651
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04326807
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03096116
82	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02971325
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01046653
84	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.00840437
85	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00560044
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00422433
87	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99892775
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98989777
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98348342
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.96514968
91	SMRT_27268052_Chip-Seq_Bcells_Human	0.96325332
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95477874
93	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94986556
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94653281
95	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94236578
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.94091120
97	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93625491
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93280129
99	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.92424711
100	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.91884195

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	4.07918366
2	MP0005394_taste/olfaction_phenotype	3.87474654
3	MP0005499_abnormal_olfactory_system	3.87474654
4	MP0008789_abnormal_olfactory_epithelium	3.62594791
5	MP0008877_abnormal_DNA_methylation	3.36937466
6	MP0001529_abnormal_vocalization	3.26156565
7	MP0000372_irregular_coat_pigmentation	3.20870572
8	MP0002102_abnormal_ear_morphology	3.16739938
9	MP0005464_abnormal_platelet_physiology	3.13684859
10	MP0008058_abnormal_DNA_repair	2.73593456
11	MP0006292_abnormal_olfactory_placode	2.56219648
12	MP0004142_abnormal_muscle_tone	2.30252583
13	MP0003195_calcinosis	2.17437272
14	MP0002909_abnormal_adrenal_gland	2.03501718
15	MP0008872_abnormal_physiological_respon	2.01048382
16	MP0001905_abnormal_dopamine_level	1.91519913
17	MP0003879_abnormal_hair_cell	1.91383206
18	MP0002234_abnormal_pharynx_morphology	1.88970089
19	MP0000015_abnormal_ear_pigmentation	1.81095882
20	MP0003656_abnormal_erythrocyte_physiolo	1.78400321
21	MP0005410_abnormal_fertilization	1.78006758
22	MP0005167_abnormal_blood-brain_barrier	1.73876608
23	MP0002876_abnormal_thyroid_physiology	1.71853163
24	MP0002090_abnormal_vision	1.64965977
25	MP0005395_other_phenotype	1.60449157
26	MP0008995_early_reproductive_senescence	1.53942079
27	MP0005646_abnormal_pituitary_gland	1.51083710
28	MP0004147_increased_porphyrin_level	1.47648562
29	MP0005551_abnormal_eye_electrophysiolog	1.47605414
30	MP0005174_abnormal_tail_pigmentation	1.45929358
31	MP0000465_gastrointestinal_hemorrhage	1.38302304
32	MP0008775_abnormal_heart_ventricle	1.37806243
33	MP0005248_abnormal_Harderian_gland	1.37283296
34	MP0009046_muscle_twitch	1.35708983
35	MP0002095_abnormal_skin_pigmentation	1.34265902
36	MP0003890_abnormal_embryonic-extraembry	1.33933618
37	MP0005645_abnormal_hypothalamus_physiol	1.33421224
38	MP0002210_abnormal_sex_determination	1.31559345
39	MP0001485_abnormal_pinna_reflex	1.30533701
40	MP0006276_abnormal_autonomic_nervous	1.29589843
41	MP0001984_abnormal_olfaction	1.25324980
42	MP0001929_abnormal_gametogenesis	1.23591443
43	MP0003786_premature_aging	1.23408208
44	MP0005636_abnormal_mineral_homeostasis	1.22122152
45	MP0001968_abnormal_touch/_nociception	1.22006943
46	MP0006036_abnormal_mitochondrial_physio	1.21948387
47	MP0005075_abnormal_melanosome_morpholog	1.21223591
48	MP0001756_abnormal_urination	1.18539778
49	MP0003186_abnormal_redox_activity	1.17875084
50	MP0005171_absent_coat_pigmentation	1.16233081
51	MP0001324_abnormal_eye_pigmentation	1.15863526
52	MP0003136_yellow_coat_color	1.11566880
53	MP0003646_muscle_fatigue	1.11334884
54	MP0002272_abnormal_nervous_system	1.10168813
55	MP0000569_abnormal_digit_pigmentation	1.09604605
56	MP0005647_abnormal_sex_gland	1.08546423
57	MP0003119_abnormal_digestive_system	1.04760630
58	MP0000653_abnormal_sex_gland	1.04550405
59	MP0009780_abnormal_chondrocyte_physiolo	1.03146693
60	MP0009765_abnormal_xenobiotic_induced	1.00589251
61	MP0003698_abnormal_male_reproductive	0.98901596
62	MP0005377_hearing/vestibular/ear_phenot	0.98758556
63	MP0003878_abnormal_ear_physiology	0.98758556
64	MP0002736_abnormal_nociception_after	0.98597952
65	MP0005083_abnormal_biliary_tract	0.95637422
66	MP0005379_endocrine/exocrine_gland_phen	0.95606962
67	MP0010094_abnormal_chromosome_stability	0.95267717
68	MP0000631_abnormal_neuroendocrine_gland	0.94452535
69	MP0002229_neurodegeneration	0.94264122
70	MP0005332_abnormal_amino_acid	0.93468788
71	MP0005671_abnormal_response_to	0.92649251
72	MP0004924_abnormal_behavior	0.91006091
73	MP0005386_behavior/neurological_phenoty	0.91006091
74	MP0008004_abnormal_stomach_pH	0.89768061
75	MP0002139_abnormal_hepatobiliary_system	0.84609125
76	MP0005253_abnormal_eye_physiology	0.84472524
77	MP0002161_abnormal_fertility/fecundity	0.83621776
78	MP0003699_abnormal_female_reproductive	0.83264462
79	MP0002067_abnormal_sensory_capabilities	0.83083608
80	MP0001145_abnormal_male_reproductive	0.82699557
81	MP0001293_anophthalmia	0.81593994
82	MP0004859_abnormal_synaptic_plasticity	0.81215358
83	MP0008932_abnormal_embryonic_tissue	0.81032717
84	MP0001486_abnormal_startle_reflex	0.80929622
85	MP0005408_hypopigmentation	0.80091771
86	MP0002837_dystrophic_cardiac_calcinosis	0.78801200
87	MP0003122_maternal_imprinting	0.78780225
88	MP0003121_genomic_imprinting	0.77923131
89	MP0001765_abnormal_ion_homeostasis	0.77824875
90	MP0000230_abnormal_systemic_arterial	0.76995116
91	MP0003183_abnormal_peptide_metabolism	0.76528305
92	MP0009745_abnormal_behavioral_response	0.74036996
93	MP0004043_abnormal_pH_regulation	0.72780811
94	MP0005058_abnormal_lysosome_morphology	0.70039277
95	MP0009763_increased_sensitivity_to	0.69336078
96	MP0006035_abnormal_mitochondrial_morpho	0.68789020
97	MP0000639_abnormal_adrenal_gland	0.68688775
98	MP0006072_abnormal_retinal_apoptosis	0.67736360
99	MP0005367_renal/urinary_system_phenotyp	0.66607043
100	MP0000516_abnormal_urinary_system	0.66607043

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	4.62127534
2	Petechiae (HP:0000967)	4.47526499
3	Double outlet right ventricle (HP:0001719)	4.14940180
4	Congenital malformation of the right heart (HP:0011723)	4.14940180
5	Oligodactyly (hands) (HP:0001180)	3.82702403
6	Abnormal gallbladder physiology (HP:0012438)	3.75020886
7	Cholecystitis (HP:0001082)	3.75020886
8	Prolonged bleeding time (HP:0003010)	3.56077525
9	Aplasia/hypoplasia of the uterus (HP:0008684)	3.50394048
10	Renal cortical cysts (HP:0000803)	3.05483107
11	Hypophosphatemic rickets (HP:0004912)	3.01705193
12	Upper limb muscle weakness (HP:0003484)	2.98537833
13	Purpura (HP:0000979)	2.97268777
14	Abdominal situs inversus (HP:0003363)	2.94729851
15	Abnormality of abdominal situs (HP:0011620)	2.94729851
16	Menorrhagia (HP:0000132)	2.93481823
17	Generalized aminoaciduria (HP:0002909)	2.80568255
18	3-Methylglutaconic aciduria (HP:0003535)	2.79917651
19	Increased mean platelet volume (HP:0011877)	2.75688216
20	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.63969679
21	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.63969679
22	Gingival bleeding (HP:0000225)	2.61235144
23	Nephronophthisis (HP:0000090)	2.57780574
24	Abolished electroretinogram (ERG) (HP:0000550)	2.54245943
25	Abnormal platelet volume (HP:0011876)	2.53003392
26	Renal Fanconi syndrome (HP:0001994)	2.52275385
27	Abnormality of the renal cortex (HP:0011035)	2.47878602
28	Median cleft lip (HP:0000161)	2.47560082
29	Abnormal auditory evoked potentials (HP:0006958)	2.47284083
30	Epistaxis (HP:0000421)	2.46106460
31	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.44391339
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.43939475
33	Hypoplasia of the fovea (HP:0007750)	2.43939475
34	Intestinal atresia (HP:0011100)	2.35281460
35	Impaired vibration sensation in the lower limbs (HP:0002166)	2.29648071
36	Hypoplasia of the uterus (HP:0000013)	2.28683278
37	Hyperlipoproteinemia (HP:0010980)	2.28401779
38	Anhidrosis (HP:0000970)	2.24329233
39	Tongue fasciculations (HP:0001308)	2.24149586
40	Oligodactyly (HP:0012165)	2.23693360
41	Hypoplasia of the thymus (HP:0000778)	2.21809338
42	Poikilocytosis (HP:0004447)	2.19126717
43	Supernumerary spleens (HP:0009799)	2.18870091
44	Abnormality of the fovea (HP:0000493)	2.18836014
45	Medial flaring of the eyebrow (HP:0010747)	2.16972837
46	Molar tooth sign on MRI (HP:0002419)	2.16920446
47	Abnormality of midbrain morphology (HP:0002418)	2.16920446
48	Gaze-evoked nystagmus (HP:0000640)	2.16333166
49	Growth hormone deficiency (HP:0000824)	2.15183857
50	Impaired platelet aggregation (HP:0003540)	2.14474706
51	Abnormal platelet function (HP:0011869)	2.14474706
52	Male infertility (HP:0003251)	2.11965477
53	Abnormality of the anterior horn cell (HP:0006802)	2.10421204
54	Degeneration of anterior horn cells (HP:0002398)	2.10421204
55	Abnormality of renal resorption (HP:0011038)	2.10000171
56	Enlarged kidneys (HP:0000105)	2.09037519
57	Exertional dyspnea (HP:0002875)	2.04963352
58	Aplasia/Hypoplasia of the macula (HP:0008059)	2.02996211
59	Urinary urgency (HP:0000012)	2.02543013
60	Truncus arteriosus (HP:0001660)	1.99055181
61	Stillbirth (HP:0003826)	1.98180301
62	Short tibia (HP:0005736)	1.97660306
63	Postural tremor (HP:0002174)	1.96220669
64	Decreased central vision (HP:0007663)	1.94797845
65	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94234179
66	Abnormality of alanine metabolism (HP:0010916)	1.92293651
67	Hyperalaninemia (HP:0003348)	1.92293651
68	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.92293651
69	Poor suck (HP:0002033)	1.91062686
70	Abnormal sex determination (HP:0012244)	1.90915147
71	Sex reversal (HP:0012245)	1.90915147
72	Severe visual impairment (HP:0001141)	1.89938463
73	Dyschromatopsia (HP:0007641)	1.88909432
74	Papillary thyroid carcinoma (HP:0002895)	1.85597117
75	Methylmalonic acidemia (HP:0002912)	1.84601667
76	Albinism (HP:0001022)	1.83746547
77	Osteomalacia (HP:0002749)	1.83694948
78	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.82801417
79	Muscle fibrillation (HP:0010546)	1.82364873
80	Abnormality of the renal medulla (HP:0100957)	1.82042692
81	Infertility (HP:0000789)	1.81627884
82	Severe combined immunodeficiency (HP:0004430)	1.78859133
83	Poor head control (HP:0002421)	1.77916897
84	Abnormality of the corticospinal tract (HP:0002492)	1.73923704
85	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.73914568
86	Lower limb hyperreflexia (HP:0002395)	1.69502579
87	Fatigue (HP:0012378)	1.69405157
88	Hepatic necrosis (HP:0002605)	1.69127670
89	Cleft eyelid (HP:0000625)	1.69105820
90	Abnormal pupillary function (HP:0007686)	1.67881131
91	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.67770039
92	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.67770039
93	Nausea (HP:0002018)	1.66087719
94	Sensory axonal neuropathy (HP:0003390)	1.64226467
95	Ankle clonus (HP:0011448)	1.64036499
96	Nephrogenic diabetes insipidus (HP:0009806)	1.63778528
97	Pancreatic islet-cell hyperplasia (HP:0004510)	1.61659125
98	Failure to thrive in infancy (HP:0001531)	1.61562711
99	Acanthocytosis (HP:0001927)	1.60643420
100	Brittle hair (HP:0002299)	1.59486736

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.36173507
2	WNK3	4.72088849
3	TAOK3	4.28781045
4	MAP3K4	3.26312214
5	EIF2AK1	2.81619287
6	MUSK	2.67242531
7	ZAK	2.58482970
8	MAP2K7	2.48772500
9	TXK	2.39793257
10	MST4	2.31258888
11	PIK3CG	2.19457338
12	TNIK	1.72467292
13	PTK2B	1.68531485
14	NEK6	1.60833677
15	ARAF	1.53130249
16	FRK	1.52968316
17	BTK	1.52032775
18	TEC	1.46768976
19	KDR	1.40849641
20	CSNK1G3	1.32397704
21	ERBB3	1.27017715
22	PLK2	1.26094875
23	MYLK	1.25927622
24	CSNK1G1	1.20118800
25	CSNK1A1L	1.08751316
26	NUAK1	1.05869596
27	CSNK1G2	1.04362417
28	CSF1R	1.01881273
29	PNCK	1.01494251
30	BMPR2	0.98728625
31	GRK1	0.97931856
32	TRIM28	0.97098020
33	PAK3	0.96648159
34	TTK	0.94734170
35	STK24	0.93705913
36	MAP3K5	0.93656888
37	ADRBK2	0.93430644
38	MAP2K4	0.92491799
39	PDK2	0.91537402
40	PLK3	0.91401538
41	GRK5	0.89609266
42	MAP3K9	0.80937212
43	MARK3	0.78095219
44	CDK9	0.77474103
45	BRSK1	0.71676155
46	STK3	0.69434236
47	FER	0.68826220
48	VRK1	0.67273468
49	INSRR	0.66126250
50	FES	0.66051867
51	CDC7	0.65895173
52	RAF1	0.65182789
53	DYRK3	0.64658530
54	MAPK13	0.63840039
55	PRKG1	0.62512475
56	BRSK2	0.62196729
57	CSNK1D	0.60100265
58	IRAK2	0.59460202
59	AURKA	0.55517701
60	HCK	0.53603570
61	MAP3K12	0.52943437
62	BRAF	0.52022505
63	ACVR1B	0.51817405
64	ATR	0.51743238
65	PKN1	0.51724984
66	CAMK2A	0.51582849
67	PRKACA	0.51500908
68	WNK1	0.51035240
69	LYN	0.49855307
70	PIM1	0.48185447
71	CAMK1G	0.47512459
72	IGF1R	0.46483988
73	TIE1	0.46214753
74	TAF1	0.46126199
75	PAK1	0.45450797
76	VRK2	0.44235140
77	DAPK1	0.42699371
78	PRKCI	0.42621931
79	TNK2	0.42614636
80	MET	0.40901526
81	BMPR1B	0.40426439
82	MAPKAPK3	0.39717124
83	NTRK3	0.39365384
84	WEE1	0.39082583
85	EIF2AK2	0.38550918
86	PRKACB	0.38241020
87	CSNK1E	0.37468358
88	ITK	0.36640281
89	TRPM7	0.36447241
90	PRKCE	0.36442969
91	DAPK2	0.35219008
92	EGFR	0.34912942
93	PRKACG	0.34505929
94	JAK3	0.33573292
95	PRKCA	0.33304489
96	GRK6	0.33201561
97	BMX	0.32619483
98	NTRK2	0.31913883
99	CDK7	0.31115224
100	STK38L	0.30889954

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.73985423
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.91716747
3	Basal transcription factors_Homo sapiens_hsa03022	2.79175102
4	Collecting duct acid secretion_Homo sapiens_hsa04966	2.58226871
5	Fatty acid elongation_Homo sapiens_hsa00062	2.57855857
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.14354581
7	Homologous recombination_Homo sapiens_hsa03440	2.12463072
8	Mismatch repair_Homo sapiens_hsa03430	2.11647448
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.11319827
10	Protein export_Homo sapiens_hsa03060	2.05329078
11	Regulation of autophagy_Homo sapiens_hsa04140	1.97991018
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94394633
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.92721349
14	Phototransduction_Homo sapiens_hsa04744	1.87915171
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81394279
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75777335
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.74976765
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.71479560
19	GABAergic synapse_Homo sapiens_hsa04727	1.71352518
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.67124429
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.58343699
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57558691
23	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.53045803
24	RNA degradation_Homo sapiens_hsa03018	1.53005668
25	Nicotine addiction_Homo sapiens_hsa05033	1.51070114
26	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.45890440
27	Oocyte meiosis_Homo sapiens_hsa04114	1.41886757
28	Olfactory transduction_Homo sapiens_hsa04740	1.40534808
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36357304
30	Parkinsons disease_Homo sapiens_hsa05012	1.36108527
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32714742
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.29811841
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28470592
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.27367803
35	Caffeine metabolism_Homo sapiens_hsa00232	1.26378139
36	Butanoate metabolism_Homo sapiens_hsa00650	1.25312825
37	Serotonergic synapse_Homo sapiens_hsa04726	1.24383571
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.22522646
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.22295655
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.21741738
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.21204435
42	Propanoate metabolism_Homo sapiens_hsa00640	1.20839779
43	Huntingtons disease_Homo sapiens_hsa05016	1.17543531
44	Tyrosine metabolism_Homo sapiens_hsa00350	1.17462529
45	RNA polymerase_Homo sapiens_hsa03020	1.13940969
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.13484611
47	Peroxisome_Homo sapiens_hsa04146	1.08907499
48	Taste transduction_Homo sapiens_hsa04742	1.07601196
49	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.07286711
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.01951209
51	Morphine addiction_Homo sapiens_hsa05032	0.99611919
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98454885
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98280411
54	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.91878127
55	Purine metabolism_Homo sapiens_hsa00230	0.90775701
56	Sulfur metabolism_Homo sapiens_hsa00920	0.90301620
57	Cell cycle_Homo sapiens_hsa04110	0.88454336
58	Vibrio cholerae infection_Homo sapiens_hsa05110	0.85664146
59	Platelet activation_Homo sapiens_hsa04611	0.85408059
60	Circadian rhythm_Homo sapiens_hsa04710	0.83661772
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82156970
62	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.81945304
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80077268
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.79306168
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78849994
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78589352
67	One carbon pool by folate_Homo sapiens_hsa00670	0.76663378
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.73442451
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72831146
70	RNA transport_Homo sapiens_hsa03013	0.71356650
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68648441
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67656755
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67405958
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.66661171
75	p53 signaling pathway_Homo sapiens_hsa04115	0.59307955
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58712364
77	Metabolic pathways_Homo sapiens_hsa01100	0.58447416
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.57797220
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56990558
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56198014
81	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54205808
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.53657498
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.53599879
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52492176
85	Alzheimers disease_Homo sapiens_hsa05010	0.52355640
86	Folate biosynthesis_Homo sapiens_hsa00790	0.49919273
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46296336
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.44480778
89	Base excision repair_Homo sapiens_hsa03410	0.43114027
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.39005265
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.35477474
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.35421090
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35333934
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34167838
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.32122721
96	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.28354520
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.26537582
98	Shigellosis_Homo sapiens_hsa05131	0.26345398
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25548839
100	Phagosome_Homo sapiens_hsa04145	0.24804294

COX7A2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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