ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	5.54606743
2	cytidine catabolic process (GO:0006216)	5.54606743
3	cytidine deamination (GO:0009972)	5.54606743
4	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	5.33779613
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.89015468
6	DNA deamination (GO:0045006)	4.71188146
7	behavioral response to nicotine (GO:0035095)	4.61725451
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.16632882
9	regulation of chronic inflammatory response (GO:0002676)	4.08547840
10	sequestering of actin monomers (GO:0042989)	4.05975703
11	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.96503142
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.96503142
13	iron-sulfur cluster assembly (GO:0016226)	3.78722492
14	metallo-sulfur cluster assembly (GO:0031163)	3.78722492
15	DNA double-strand break processing (GO:0000729)	3.77434788
16	protein neddylation (GO:0045116)	3.73391819
17	auditory receptor cell stereocilium organization (GO:0060088)	3.54737018
18	protein-cofactor linkage (GO:0018065)	3.53773841
19	negative regulation of mast cell activation (GO:0033004)	3.51682307
20	positive regulation of interleukin-8 secretion (GO:2000484)	3.48241081
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.46715805
22	L-fucose catabolic process (GO:0042355)	3.43856724
23	fucose catabolic process (GO:0019317)	3.43856724
24	L-fucose metabolic process (GO:0042354)	3.43856724
25	DNA demethylation (GO:0080111)	3.37866976
26	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.34933144
27	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.27847277
28	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.24477763
29	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.23402001
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.20143911
31	ATP synthesis coupled proton transport (GO:0015986)	3.20143911
32	DNA dealkylation (GO:0035510)	3.15736705
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15713392
34	dopamine transport (GO:0015872)	3.11788027
35	respiratory electron transport chain (GO:0022904)	3.11309346
36	electron transport chain (GO:0022900)	3.07462355
37	platelet dense granule organization (GO:0060155)	3.06355778
38	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.03739142
39	cullin deneddylation (GO:0010388)	3.00807547
40	regulation of cellular amino acid metabolic process (GO:0006521)	3.00374614
41	rRNA modification (GO:0000154)	2.99947622
42	regulation of B cell receptor signaling pathway (GO:0050855)	2.98986304
43	epithelial cilium movement (GO:0003351)	2.98352262
44	isoprenoid biosynthetic process (GO:0008299)	2.94293801
45	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.94284798
46	response to inactivity (GO:0014854)	2.93895735
47	proteasome assembly (GO:0043248)	2.91914520
48	regulation of interleukin-8 secretion (GO:2000482)	2.90091975
49	ubiquinone metabolic process (GO:0006743)	2.89713795
50	intraciliary transport (GO:0042073)	2.89490662
51	photoreceptor cell development (GO:0042461)	2.89139443
52	transmission of nerve impulse (GO:0019226)	2.89035747
53	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.88079069
54	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.88079069
55	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.88079069
56	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.85201656
57	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.82145565
58	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.81085249
59	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.81085249
60	somite development (GO:0061053)	2.80143160
61	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.78960386
62	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.78584354
63	detection of light stimulus involved in sensory perception (GO:0050962)	2.75380434
64	detection of light stimulus involved in visual perception (GO:0050908)	2.75380434
65	protein complex biogenesis (GO:0070271)	2.74001917
66	terpenoid biosynthetic process (GO:0016114)	2.72970812
67	ubiquinone biosynthetic process (GO:0006744)	2.72770372
68	tyrosine phosphorylation of STAT protein (GO:0007260)	2.71867594
69	regulation of regulatory T cell differentiation (GO:0045589)	2.70976867
70	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.70283416
71	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.70283416
72	positive regulation of defense response to virus by host (GO:0002230)	2.68518961
73	pyrimidine-containing compound catabolic process (GO:0072529)	2.68378753
74	mechanosensory behavior (GO:0007638)	2.67633431
75	activated T cell proliferation (GO:0050798)	2.65345637
76	GPI anchor metabolic process (GO:0006505)	2.63940523
77	eye photoreceptor cell development (GO:0042462)	2.63578717
78	negative regulation of B cell proliferation (GO:0030889)	2.63173309
79	pseudouridine synthesis (GO:0001522)	2.60420735
80	base-excision repair, AP site formation (GO:0006285)	2.58073846
81	ribosomal small subunit assembly (GO:0000028)	2.57462260
82	rRNA methylation (GO:0031167)	2.57070981
83	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.56993596
84	protein deneddylation (GO:0000338)	2.54114569
85	inner ear receptor stereocilium organization (GO:0060122)	2.53968913
86	intestinal epithelial cell development (GO:0060576)	2.52567894
87	cyclooxygenase pathway (GO:0019371)	2.50328886
88	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.49162410
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47888629
90	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.47788149
91	spinal cord association neuron differentiation (GO:0021527)	2.47437497
92	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.43774030
93	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.43694305
94	NADH dehydrogenase complex assembly (GO:0010257)	2.43694305
95	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.43694305
96	parturition (GO:0007567)	2.41940985
97	synaptic transmission, cholinergic (GO:0007271)	2.41803231
98	regulation of action potential (GO:0098900)	2.41298055
99	regulation of T cell chemotaxis (GO:0010819)	2.41229324
100	positive regulation of T cell chemotaxis (GO:0010820)	2.41229324

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.41650782
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.68950543
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.61662894
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.29815558
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23683491
6	VDR_22108803_ChIP-Seq_LS180_Human	3.09015468
7	IGF1R_20145208_ChIP-Seq_DFB_Human	3.07312940
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.81760847
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.65997673
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.65242693
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.59523453
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43834860
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.35964674
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31387508
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.05918782
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94303192
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.92486761
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92462430
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89283084
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86976199
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82109622
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.78528652
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.75863470
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.64808148
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64167713
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.63944964
27	P300_19829295_ChIP-Seq_ESCs_Human	1.59735293
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.59039452
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.55406613
30	EWS_26573619_Chip-Seq_HEK293_Human	1.51146819
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50973646
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48716534
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45147696
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42741213
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.42390034
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40146839
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37039305
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37039305
39	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.32106821
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31688135
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30655900
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30551500
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28744972
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28446659
45	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.28047643
46	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.26332123
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25391925
48	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.24120273
49	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22577796
50	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.21492010
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20500691
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20233839
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20233839
54	FUS_26573619_Chip-Seq_HEK293_Human	1.20034197
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19866597
56	GATA3_26560356_Chip-Seq_TH2_Human	1.19368863
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15631330
58	GBX2_23144817_ChIP-Seq_PC3_Human	1.14622729
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.13918112
60	AR_20517297_ChIP-Seq_VCAP_Human	1.12900784
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.12312670
62	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12136192
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10969121
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.10969121
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10173434
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08324162
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08299661
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07668767
69	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.06922217
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06737137
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04828257
72	NCOR_22424771_ChIP-Seq_293T_Human	1.04767864
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04393082
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04058493
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03877847
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.03028376
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02050144
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.01652660
79	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.01434818
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99790333
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97857562
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95695137
83	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95685366
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95588623
85	BCAT_22108803_ChIP-Seq_LS180_Human	0.94367556
86	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93239330
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92975599
88	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92082007
89	AR_25329375_ChIP-Seq_VCAP_Human	0.91083890
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90653543
91	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.90075707
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89487189
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.88740066
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.88373689
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.88134062
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.87847952
97	OCT4_20526341_ChIP-Seq_ESCs_Human	0.87705711
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.87402554
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.86584402
100	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.85503539

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	4.19262901
2	MP0002102_abnormal_ear_morphology	3.11572576
3	MP0005671_abnormal_response_to	2.65969279
4	MP0004147_increased_porphyrin_level	2.54516899
5	MP0000372_irregular_coat_pigmentation	2.21934096
6	MP0003880_abnormal_central_pattern	2.11852234
7	MP0004885_abnormal_endolymph	2.08526950
8	MP0006276_abnormal_autonomic_nervous	2.08107689
9	MP0006292_abnormal_olfactory_placode	2.05374723
10	MP0001529_abnormal_vocalization	2.04297497
11	MP0009785_altered_susceptibility_to	1.99776072
12	MP0002653_abnormal_ependyma_morphology	1.99247558
13	MP0005551_abnormal_eye_electrophysiolog	1.95538229
14	MP0002272_abnormal_nervous_system	1.88343983
15	MP0002876_abnormal_thyroid_physiology	1.86387563
16	MP0003011_delayed_dark_adaptation	1.84440473
17	MP0002138_abnormal_hepatobiliary_system	1.81983116
18	MP0001873_stomach_inflammation	1.78121052
19	MP0001919_abnormal_reproductive_system	1.76970754
20	MP0006072_abnormal_retinal_apoptosis	1.76134930
21	MP0008872_abnormal_physiological_respon	1.65278273
22	MP0003878_abnormal_ear_physiology	1.64715865
23	MP0005377_hearing/vestibular/ear_phenot	1.64715865
24	MP0004142_abnormal_muscle_tone	1.64209115
25	MP0002163_abnormal_gland_morphology	1.63441971
26	MP0001986_abnormal_taste_sensitivity	1.60243531
27	MP0001486_abnormal_startle_reflex	1.56159289
28	MP0003136_yellow_coat_color	1.55894243
29	MP0001501_abnormal_sleep_pattern	1.54379222
30	MP0005389_reproductive_system_phenotype	1.51246429
31	MP0004742_abnormal_vestibular_system	1.50533777
32	MP0001905_abnormal_dopamine_level	1.48768347
33	MP0005253_abnormal_eye_physiology	1.46983654
34	MP0005646_abnormal_pituitary_gland	1.44768374
35	MP0009745_abnormal_behavioral_response	1.44481161
36	MP0008995_early_reproductive_senescence	1.41616378
37	MP0002837_dystrophic_cardiac_calcinosis	1.40768508
38	MP0002638_abnormal_pupillary_reflex	1.40732522
39	MP0002234_abnormal_pharynx_morphology	1.40212733
40	MP0008789_abnormal_olfactory_epithelium	1.38985394
41	MP0003866_abnormal_defecation	1.37811006
42	MP0008875_abnormal_xenobiotic_pharmacok	1.34213200
43	MP0002095_abnormal_skin_pigmentation	1.31575920
44	MP0005075_abnormal_melanosome_morpholog	1.27131436
45	MP0001485_abnormal_pinna_reflex	1.26354582
46	MP0001968_abnormal_touch/_nociception	1.25923361
47	MP0001970_abnormal_pain_threshold	1.24387780
48	MP0002933_joint_inflammation	1.21927181
49	MP0001188_hyperpigmentation	1.20927664
50	MP0003195_calcinosis	1.20680869
51	MP0009764_decreased_sensitivity_to	1.19643933
52	MP0008877_abnormal_DNA_methylation	1.18548724
53	MP0002822_catalepsy	1.11213048
54	MP0003787_abnormal_imprinting	1.10695799
55	MP0002733_abnormal_thermal_nociception	1.10303835
56	MP0001542_abnormal_bone_strength	1.09023276
57	MP0000026_abnormal_inner_ear	1.09020143
58	MP0005387_immune_system_phenotype	1.08535813
59	MP0001790_abnormal_immune_system	1.08535813
60	MP0003763_abnormal_thymus_physiology	1.07796094
61	MP0002148_abnormal_hypersensitivity_rea	1.06201830
62	MP0002752_abnormal_somatic_nervous	1.05423657
63	MP0002282_abnormal_trachea_morphology	1.05244015
64	MP0003646_muscle_fatigue	1.05014880
65	MP0002572_abnormal_emotion/affect_behav	1.02573872
66	MP0000049_abnormal_middle_ear	1.02344940
67	MP0003724_increased_susceptibility_to	1.00415220
68	MP0010386_abnormal_urinary_bladder	0.99790553
69	MP0001963_abnormal_hearing_physiology	0.99637553
70	MP0003938_abnormal_ear_development	0.97953441
71	MP0005499_abnormal_olfactory_system	0.97848913
72	MP0005394_taste/olfaction_phenotype	0.97848913
73	MP0009046_muscle_twitch	0.97736079
74	MP0005195_abnormal_posterior_eye	0.95023446
75	MP0005167_abnormal_blood-brain_barrier	0.94030171
76	MP0001800_abnormal_humoral_immune	0.93857433
77	MP0001324_abnormal_eye_pigmentation	0.93225511
78	MP0005000_abnormal_immune_tolerance	0.92676604
79	MP0002735_abnormal_chemical_nociception	0.92496438
80	MP0002184_abnormal_innervation	0.92174079
81	MP0002063_abnormal_learning/memory/cond	0.91878649
82	MP0000631_abnormal_neuroendocrine_gland	0.91776831
83	MP0001764_abnormal_homeostasis	0.91624997
84	MP0002557_abnormal_social/conspecific_i	0.91250574
85	MP0001835_abnormal_antigen_presentation	0.90363058
86	MP0002751_abnormal_autonomic_nervous	0.88620385
87	MP0000647_abnormal_sebaceous_gland	0.87777812
88	MP0002277_abnormal_respiratory_mucosa	0.86854597
89	MP0005187_abnormal_penis_morphology	0.86448420
90	MP0003567_abnormal_fetal_cardiomyocyte	0.85485000
91	MP0002734_abnormal_mechanical_nocicepti	0.84939032
92	MP0002160_abnormal_reproductive_system	0.84308843
93	MP0003635_abnormal_synaptic_transmissio	0.83260916
94	MP0005379_endocrine/exocrine_gland_phen	0.82515187
95	MP0009379_abnormal_foot_pigmentation	0.82185678
96	MP0003718_maternal_effect	0.79785783
97	MP0005174_abnormal_tail_pigmentation	0.79205212
98	MP0000685_abnormal_immune_system	0.79092703
99	MP0002736_abnormal_nociception_after	0.78613477
100	MP0005310_abnormal_salivary_gland	0.77728415

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.49166980
2	Abnormality of midbrain morphology (HP:0002418)	4.05281035
3	Molar tooth sign on MRI (HP:0002419)	4.05281035
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.04062562
5	Acute encephalopathy (HP:0006846)	4.00510932
6	Progressive macrocephaly (HP:0004481)	3.89446464
7	Abnormality of the prostate (HP:0008775)	3.59323484
8	Mitochondrial inheritance (HP:0001427)	3.47604103
9	IgG deficiency (HP:0004315)	3.32221423
10	Nephronophthisis (HP:0000090)	3.26657733
11	Abnormality of B cell number (HP:0010975)	3.23871895
12	Increased CSF lactate (HP:0002490)	3.23663919
13	Lipid accumulation in hepatocytes (HP:0006561)	3.13880658
14	Retinal dysplasia (HP:0007973)	3.05063875
15	Medial flaring of the eyebrow (HP:0010747)	3.00597672
16	Type II lissencephaly (HP:0007260)	2.99240913
17	Decreased central vision (HP:0007663)	2.97237870
18	Methylmalonic acidemia (HP:0002912)	2.97183816
19	True hermaphroditism (HP:0010459)	2.94981108
20	Congenital stationary night blindness (HP:0007642)	2.91011230
21	Pancreatic cysts (HP:0001737)	2.85065083
22	Stomach cancer (HP:0012126)	2.81127594
23	Hypoplasia of the pons (HP:0012110)	2.72133406
24	Increased hepatocellular lipid droplets (HP:0006565)	2.71195052
25	B lymphocytopenia (HP:0010976)	2.69255387
26	Abnormality of the renal medulla (HP:0100957)	2.65841847
27	Optic disc pallor (HP:0000543)	2.65699306
28	Cerebral edema (HP:0002181)	2.62298280
29	Hepatocellular necrosis (HP:0001404)	2.60517462
30	Pancreatic fibrosis (HP:0100732)	2.55509747
31	Increased intramyocellular lipid droplets (HP:0012240)	2.54554952
32	Abnormality of the pons (HP:0007361)	2.48709125
33	Increased muscle lipid content (HP:0009058)	2.47464425
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45194405
35	Hepatic necrosis (HP:0002605)	2.42778387
36	Severe combined immunodeficiency (HP:0004430)	2.42664139
37	Hypoproteinemia (HP:0003075)	2.41017872
38	Type 2 muscle fiber atrophy (HP:0003554)	2.40869714
39	Autoimmune hemolytic anemia (HP:0001890)	2.36220885
40	Methylmalonic aciduria (HP:0012120)	2.31387696
41	Thyroid-stimulating hormone excess (HP:0002925)	2.29981987
42	Gastrointestinal infarctions (HP:0005244)	2.29417498
43	Lethargy (HP:0001254)	2.26832068
44	Abnormality of male internal genitalia (HP:0000022)	2.26740494
45	Abolished electroretinogram (ERG) (HP:0000550)	2.23005713
46	Increased serum lactate (HP:0002151)	2.21779221
47	Hemoptysis (HP:0002105)	2.19466011
48	Attenuation of retinal blood vessels (HP:0007843)	2.17219304
49	3-Methylglutaconic aciduria (HP:0003535)	2.16031082
50	Sclerocornea (HP:0000647)	2.15667097
51	Lactic acidosis (HP:0003128)	2.14766254
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.12314734
53	Thyroiditis (HP:0100646)	2.10260726
54	Ureteral stenosis (HP:0000071)	2.09422807
55	Elevated erythrocyte sedimentation rate (HP:0003565)	2.09023482
56	Congenital, generalized hypertrichosis (HP:0004540)	2.08540879
57	Lissencephaly (HP:0001339)	2.05943133
58	Seborrheic dermatitis (HP:0001051)	2.05541583
59	Ketoacidosis (HP:0001993)	2.03853719
60	Leukodystrophy (HP:0002415)	2.03422896
61	Gait imbalance (HP:0002141)	2.02152054
62	Increased IgM level (HP:0003496)	1.99153137
63	Tachypnea (HP:0002789)	1.96219173
64	Delayed CNS myelination (HP:0002188)	1.95295688
65	Nephrogenic diabetes insipidus (HP:0009806)	1.95161077
66	Gangrene (HP:0100758)	1.92659140
67	Abnormality of the renal cortex (HP:0011035)	1.92258071
68	Congenital primary aphakia (HP:0007707)	1.91384695
69	Progressive cerebellar ataxia (HP:0002073)	1.90319454
70	Rib fusion (HP:0000902)	1.89966038
71	Gaze-evoked nystagmus (HP:0000640)	1.89682082
72	Hypoplasia of the uterus (HP:0000013)	1.89657256
73	Hypomagnesemia (HP:0002917)	1.89498533
74	Pendular nystagmus (HP:0012043)	1.87724617
75	Broad-based gait (HP:0002136)	1.87389148
76	Autoimmune thrombocytopenia (HP:0001973)	1.87131547
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86980898
78	Respiratory failure (HP:0002878)	1.86371589
79	Ureteral obstruction (HP:0006000)	1.85553866
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.84058971
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82014301
82	Abnormality of eosinophils (HP:0001879)	1.80996766
83	Chest pain (HP:0100749)	1.79783468
84	Agitation (HP:0000713)	1.79717528
85	Prostate neoplasm (HP:0100787)	1.78679492
86	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.78580086
87	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.78580086
88	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.77551977
89	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.77551977
90	Combined immunodeficiency (HP:0005387)	1.77542488
91	Cerebellar dysplasia (HP:0007033)	1.77162086
92	Renal Fanconi syndrome (HP:0001994)	1.75555503
93	Erythroderma (HP:0001019)	1.74434353
94	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.74132558
95	Pancreatitis (HP:0001733)	1.74067697
96	Concave nail (HP:0001598)	1.73624737
97	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.72993797
98	Postaxial hand polydactyly (HP:0001162)	1.72583766
99	Muscle fiber atrophy (HP:0100295)	1.71496402
100	Ketosis (HP:0001946)	1.71299175

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.01844594
2	MST4	3.05904437
3	BMPR1B	2.92791793
4	ADRBK2	2.72793825
5	MAP2K7	2.62913399
6	ZAK	2.49008776
7	BCR	2.42444501
8	MAP4K2	2.25760356
9	STK16	2.23482267
10	WNK3	2.14232101
11	TAOK3	2.02097410
12	FRK	2.00911393
13	WNK4	2.00877238
14	CDK8	1.98404877
15	EPHA3	1.91031194
16	TLK1	1.88884066
17	GRK1	1.85508729
18	TRIM28	1.84282989
19	MUSK	1.81354743
20	PINK1	1.75257317
21	GRK6	1.66769797
22	PIK3CA	1.53203581
23	RIPK4	1.49088199
24	PLK2	1.48655660
25	KDR	1.43067109
26	MAP3K4	1.42253565
27	BMPR2	1.33761216
28	CASK	1.29887896
29	MARK1	1.27574173
30	VRK1	1.27021570
31	MAPK13	1.23493301
32	CSNK1G3	1.21055580
33	NEK1	1.18788590
34	VRK2	1.18365362
35	PHKG1	1.18128483
36	PHKG2	1.18128483
37	STK39	1.14376870
38	EPHA4	1.13316364
39	TYRO3	1.12939789
40	CSNK1G2	1.12558117
41	KIT	1.08893680
42	BCKDK	1.05322834
43	CSNK1A1L	1.03393108
44	ITK	1.02031104
45	GRK7	0.99371722
46	MATK	0.95724779
47	SRPK1	0.95492823
48	SIK3	0.88603506
49	CSNK1G1	0.87425406
50	SYK	0.87039550
51	EPHB2	0.86917469
52	OXSR1	0.86915880
53	TSSK6	0.85919222
54	IKBKB	0.85351372
55	NTRK2	0.82408265
56	DYRK2	0.80946664
57	PLK3	0.80113420
58	TEC	0.77479139
59	OBSCN	0.72685796
60	FER	0.71030576
61	GRK5	0.68607154
62	INSRR	0.64527669
63	PRKCG	0.63704161
64	NME1	0.63522668
65	MAP2K2	0.61126287
66	NUAK1	0.59000258
67	FES	0.58951452
68	PRKCE	0.58896708
69	MINK1	0.57735911
70	PRKD3	0.56375571
71	CAMK2A	0.56021339
72	TIE1	0.55194817
73	CDK19	0.53786835
74	LCK	0.53065732
75	ERBB3	0.52931754
76	PRKACA	0.52807035
77	CAMKK2	0.51538801
78	IGF1R	0.51251019
79	CSNK1D	0.49749417
80	CSNK1A1	0.46974843
81	PRKCH	0.46884829
82	PKN1	0.46080061
83	MAPK15	0.45203084
84	ADRBK1	0.42619575
85	CAMK1	0.40814666
86	PAK3	0.40670235
87	MAP3K9	0.40467021
88	MAP2K6	0.38466128
89	EIF2AK2	0.37666861
90	PRKCA	0.37297144
91	RPS6KA5	0.36607784
92	PIM2	0.35630491
93	BTK	0.34184494
94	EIF2AK3	0.33254496
95	CAMK4	0.32014438
96	CSF1R	0.30922209
97	PLK1	0.30902517
98	PLK4	0.30666172
99	CLK1	0.30043336
100	RPS6KA4	0.30030646

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.87813238
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.54670939
3	Parkinsons disease_Homo sapiens_hsa05012	2.88022223
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.65632329
5	Protein export_Homo sapiens_hsa03060	2.50492677
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.47182200
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.45808295
8	Phototransduction_Homo sapiens_hsa04744	2.41870348
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.22783604
10	Asthma_Homo sapiens_hsa05310	2.21655583
11	Allograft rejection_Homo sapiens_hsa05330	2.11530543
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.05667023
13	Basal transcription factors_Homo sapiens_hsa03022	1.96979694
14	Alzheimers disease_Homo sapiens_hsa05010	1.89131920
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.88382911
16	RNA polymerase_Homo sapiens_hsa03020	1.86911536
17	Homologous recombination_Homo sapiens_hsa03440	1.84825256
18	Huntingtons disease_Homo sapiens_hsa05016	1.83118458
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.82382750
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.82257168
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.78924775
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69834798
23	Butanoate metabolism_Homo sapiens_hsa00650	1.67069054
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.65340444
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.60876150
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58857569
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.55611039
28	Propanoate metabolism_Homo sapiens_hsa00640	1.50205832
29	RNA degradation_Homo sapiens_hsa03018	1.49277158
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.48829601
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.44971878
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41108373
33	Ribosome_Homo sapiens_hsa03010	1.40833351
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28501397
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24092233
36	Rheumatoid arthritis_Homo sapiens_hsa05323	1.21579782
37	Nicotine addiction_Homo sapiens_hsa05033	1.21557324
38	Caffeine metabolism_Homo sapiens_hsa00232	1.20205313
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.18919212
40	Olfactory transduction_Homo sapiens_hsa04740	1.12137978
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.11633125
42	Sulfur metabolism_Homo sapiens_hsa00920	1.05702631
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.03597440
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00037218
45	Morphine addiction_Homo sapiens_hsa05032	0.99278810
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97517821
47	GABAergic synapse_Homo sapiens_hsa04727	0.96439995
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.94032828
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.93364714
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.87617671
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.86583155
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.77761201
53	Spliceosome_Homo sapiens_hsa03040	0.76452914
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76255030
55	Purine metabolism_Homo sapiens_hsa00230	0.74781963
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74650494
57	Taste transduction_Homo sapiens_hsa04742	0.73727228
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.73273997
59	Mismatch repair_Homo sapiens_hsa03430	0.72415706
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68483238
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67643546
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65930145
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65755190
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63527010
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.62727042
66	Peroxisome_Homo sapiens_hsa04146	0.61909503
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.61776843
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.60776583
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60433593
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60275707
71	Metabolic pathways_Homo sapiens_hsa01100	0.59441668
72	Circadian entrainment_Homo sapiens_hsa04713	0.59068132
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57627744
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55137723
75	One carbon pool by folate_Homo sapiens_hsa00670	0.54609301
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52619455
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49228714
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48555570
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47496226
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46805517
81	Regulation of autophagy_Homo sapiens_hsa04140	0.45359885
82	Insulin secretion_Homo sapiens_hsa04911	0.42009538
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40409258
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40191511
85	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40097295
86	Circadian rhythm_Homo sapiens_hsa04710	0.39549001
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.38394781
88	Serotonergic synapse_Homo sapiens_hsa04726	0.38230457
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33101835
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.31555685
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31506683
92	Retinol metabolism_Homo sapiens_hsa00830	0.29718269
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.27916497
94	Cholinergic synapse_Homo sapiens_hsa04725	0.26319637
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24638035
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.24422962
97	Base excision repair_Homo sapiens_hsa03410	0.22827195
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19793312
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.19693907
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.19261727

COX7A2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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