COX7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.70616974
2* respiratory electron transport chain (GO:0022904)9.10060446
3* electron transport chain (GO:0022900)8.87043636
4oxidative phosphorylation (GO:0006119)6.04795673
5ATP biosynthetic process (GO:0006754)6.04093243
6purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.48900478
7purine nucleoside triphosphate biosynthetic process (GO:0009145)5.41505808
8* hydrogen ion transmembrane transport (GO:1902600)5.33065026
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.32121620
10inner mitochondrial membrane organization (GO:0007007)5.25486796
11chaperone-mediated protein transport (GO:0072321)5.17115898
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.07268158
13mitochondrial respiratory chain complex I assembly (GO:0032981)5.07268158
14NADH dehydrogenase complex assembly (GO:0010257)5.07268158
15protein complex biogenesis (GO:0070271)5.00618293
16tricarboxylic acid cycle (GO:0006099)4.91989929
17ribonucleoside triphosphate biosynthetic process (GO:0009201)4.80782469
18ribosomal small subunit biogenesis (GO:0042274)4.62846649
19viral transcription (GO:0019083)4.62280171
20* proton transport (GO:0015992)4.60978001
21mitochondrial respiratory chain complex assembly (GO:0033108)4.60680874
22* hydrogen transport (GO:0006818)4.54447654
23translational termination (GO:0006415)4.45013498
24regulation of oxidative phosphorylation (GO:0002082)4.20839295
25aerobic respiration (GO:0009060)4.15494462
26nucleoside triphosphate biosynthetic process (GO:0009142)4.14793758
27proteasome assembly (GO:0043248)4.05350659
28protein neddylation (GO:0045116)4.01915124
29regulation of acyl-CoA biosynthetic process (GO:0050812)4.01202225
30cotranslational protein targeting to membrane (GO:0006613)3.93103736
31NADH metabolic process (GO:0006734)3.91977903
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.88507223
33protein targeting to ER (GO:0045047)3.88042117
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.82491129
35water-soluble vitamin biosynthetic process (GO:0042364)3.81133689
36mitochondrial transport (GO:0006839)3.78733572
37regulation of coenzyme metabolic process (GO:0051196)3.77854494
38regulation of cofactor metabolic process (GO:0051193)3.77854494
39behavioral response to nicotine (GO:0035095)3.77117333
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73821840
41translational elongation (GO:0006414)3.72943323
42protein localization to endoplasmic reticulum (GO:0070972)3.70720307
43purine nucleoside monophosphate biosynthetic process (GO:0009127)3.66604329
44purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.66604329
45regulation of mitochondrial translation (GO:0070129)3.66535726
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.61010540
47regulation of cellular respiration (GO:0043457)3.60579642
48succinate metabolic process (GO:0006105)3.60376948
49cellular protein complex disassembly (GO:0043624)3.55793824
50GTP biosynthetic process (GO:0006183)3.55725799
51* generation of precursor metabolites and energy (GO:0006091)3.51288205
52cellular respiration (GO:0045333)3.48895942
53termination of RNA polymerase III transcription (GO:0006386)3.47754895
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.47754895
55viral life cycle (GO:0019058)3.45070464
56ATP hydrolysis coupled proton transport (GO:0015991)3.39719859
57energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.39719859
58negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.35488412
59protein targeting to mitochondrion (GO:0006626)3.29393912
60establishment of protein localization to mitochondrion (GO:0072655)3.28336902
61ubiquinone biosynthetic process (GO:0006744)3.27203466
62quinone biosynthetic process (GO:1901663)3.27203466
63ribosomal small subunit assembly (GO:0000028)3.26291726
64regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.25844710
65regulation of cell communication by electrical coupling (GO:0010649)3.24401796
66cellular ketone body metabolic process (GO:0046950)3.24202598
67protein localization to mitochondrion (GO:0070585)3.23663840
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22717620
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.20964937
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18636707
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18636707
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18059056
73maturation of SSU-rRNA (GO:0030490)3.13980959
74regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.13360699
75sarcomere organization (GO:0045214)3.10025488
76purine nucleoside biosynthetic process (GO:0042451)3.08920160
77purine ribonucleoside biosynthetic process (GO:0046129)3.08920160
78sequestering of actin monomers (GO:0042989)3.08405204
79respiratory chain complex IV assembly (GO:0008535)3.06634245
80translation (GO:0006412)2.97859769
81ubiquinone metabolic process (GO:0006743)2.97352021
82heart contraction (GO:0060047)2.96969439
83heart process (GO:0003015)2.96969439
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96317826
85cytochrome complex assembly (GO:0017004)2.95551043
86ketone body metabolic process (GO:1902224)2.94081877
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93853997
88UTP biosynthetic process (GO:0006228)2.93785928
89dopamine transport (GO:0015872)2.92752763
90calcium-mediated signaling using intracellular calcium source (GO:0035584)2.90901973
91ribonucleoside monophosphate biosynthetic process (GO:0009156)2.90505804
92translational initiation (GO:0006413)2.90326044
93cellular component biogenesis (GO:0044085)2.86750445
94oxaloacetate metabolic process (GO:0006107)2.86315803
95actin-myosin filament sliding (GO:0033275)2.84467074
96muscle filament sliding (GO:0030049)2.84467074
97regulation of sulfur metabolic process (GO:0042762)2.84444559
98negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.82907670
99intracellular protein transmembrane import (GO:0044743)2.82899806
100regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.82110624
101ribosomal large subunit biogenesis (GO:0042273)2.80253813
102protein complex disassembly (GO:0043241)2.79755846
103positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79008562
104sarcoplasmic reticulum calcium ion transport (GO:0070296)2.78317290
105UTP metabolic process (GO:0046051)2.75352825
106regulation of cellular amino acid metabolic process (GO:0006521)2.75219782
107protein-cofactor linkage (GO:0018065)2.72911433
108regulation of relaxation of muscle (GO:1901077)2.71899469
109macromolecular complex disassembly (GO:0032984)2.68951174
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67811759
111nucleoside monophosphate biosynthetic process (GO:0009124)2.67803981
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63263838
113negative regulation of ligase activity (GO:0051352)2.63263838
114protein targeting to membrane (GO:0006612)2.63212514
115ribonucleoside biosynthetic process (GO:0042455)2.61274969
116organelle disassembly (GO:1903008)2.54773785
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.54094850
118pseudouridine synthesis (GO:0001522)2.53728226
119DNA deamination (GO:0045006)2.53441443
120platelet dense granule organization (GO:0060155)2.51834678
121intracellular protein transmembrane transport (GO:0065002)2.51819059
122signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.48610561
123signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.48610561
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.48610561
125positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.47207760
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46816108
127aldehyde catabolic process (GO:0046185)2.46627272
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.44545543
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.44545543
130protein transmembrane transport (GO:0071806)2.43469765
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41731071
132rRNA modification (GO:0000154)2.41502223
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)11.6088756
134energy coupled proton transport, down electrochemical gradient (GO:0015985)10.8623721
135ATP synthesis coupled proton transport (GO:0015986)10.8623721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39298964
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.13564174
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83960502
4EZH2_22144423_ChIP-Seq_EOC_Human3.80884526
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62529585
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.33070822
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05341710
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.02357428
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70266314
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59325360
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52689695
12VDR_22108803_ChIP-Seq_LS180_Human2.51711227
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49855778
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.48002217
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44917677
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42884684
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35872623
18TAF15_26573619_Chip-Seq_HEK293_Human2.35631683
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31277671
20* MYC_18555785_ChIP-Seq_MESCs_Mouse2.25234541
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.22300097
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98724242
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94876328
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81128784
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.80269495
26* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78691756
27EWS_26573619_Chip-Seq_HEK293_Human1.77587135
28IGF1R_20145208_ChIP-Seq_DFB_Human1.73821201
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64419263
30DCP1A_22483619_ChIP-Seq_HELA_Human1.63989265
31GBX2_23144817_ChIP-Seq_PC3_Human1.61333501
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59726556
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58184355
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58069971
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.57432927
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50882625
37FUS_26573619_Chip-Seq_HEK293_Human1.50545382
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50079109
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49740618
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47097826
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.44740579
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44637369
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.43809931
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43697621
45TP53_22573176_ChIP-Seq_HFKS_Human1.42653693
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38783922
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38210171
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37586939
49ELK1_19687146_ChIP-ChIP_HELA_Human1.36316625
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.35397621
51IRF1_19129219_ChIP-ChIP_H3396_Human1.34461469
52TTF2_22483619_ChIP-Seq_HELA_Human1.27536723
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26173594
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25816727
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23905083
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23728692
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23314188
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22373269
59ZNF274_21170338_ChIP-Seq_K562_Hela1.22011265
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20367387
61CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20001945
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19288094
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17449711
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17030771
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15610075
66* VDR_23849224_ChIP-Seq_CD4+_Human1.14654352
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14112381
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13781408
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13146632
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12432310
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12369316
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.12369316
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12006788
74* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11637136
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11419040
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11265566
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09852520
78GABP_19822575_ChIP-Seq_HepG2_Human1.08012521
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07737500
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.06650010
81XRN2_22483619_ChIP-Seq_HELA_Human1.06348766
82NANOG_19829295_ChIP-Seq_ESCs_Human1.05969630
83SOX2_19829295_ChIP-Seq_ESCs_Human1.05969630
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05865900
85P300_19829295_ChIP-Seq_ESCs_Human1.05685557
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04710789
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03749960
88RNF2_27304074_Chip-Seq_NSC_Mouse1.03216183
89MYC_18940864_ChIP-ChIP_HL60_Human1.03134450
90NCOR_22424771_ChIP-Seq_293T_Human1.02162560
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.01580109
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00805793
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99355425
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99022690
95HTT_18923047_ChIP-ChIP_STHdh_Human0.98484021
96EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98354356
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98354356
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98077851
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.96758813
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96734094
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96633502
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96280035
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96018592
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94926907
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94866175
106NANOG_16153702_ChIP-ChIP_HESCs_Human0.93966269
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.93699362
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93019478
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92364827
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92127907
111ER_23166858_ChIP-Seq_MCF-7_Human0.91820595
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91167974
113ZNF263_19887448_ChIP-Seq_K562_Human0.90181990
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89797274
115AR_20517297_ChIP-Seq_VCAP_Human0.89493531
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89357980
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.88449828
118ERG_20517297_ChIP-Seq_VCAP_Human0.88043553
119BCAT_22108803_ChIP-Seq_LS180_Human0.87731914
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87583964
121CBP_20019798_ChIP-Seq_JUKART_Human0.87583964
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87268470
123REST_21632747_ChIP-Seq_MESCs_Mouse0.87184289
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87116830
125* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87067083
126FOXP3_21729870_ChIP-Seq_TREG_Human0.86741252
127GATA3_21878914_ChIP-Seq_MCF-7_Human0.86393683
128MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86030063
129REST_18959480_ChIP-ChIP_MESCs_Mouse0.85623190
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84750496
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83825811
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80717338
133JUN_21703547_ChIP-Seq_K562_Human0.79772110
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.77085239
135REST_19997604_ChIP-ChIP_NEURONS_Mouse0.76962146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.75896267
2MP0003646_muscle_fatigue4.23239078
3MP0009379_abnormal_foot_pigmentation3.60391097
4MP0003880_abnormal_central_pattern3.60082370
5MP0004215_abnormal_myocardial_fiber3.41219457
6MP0006036_abnormal_mitochondrial_physio3.24555780
7MP0000751_myopathy3.21196428
8MP0004084_abnormal_cardiac_muscle2.79498740
9MP0001529_abnormal_vocalization2.70408426
10MP0006276_abnormal_autonomic_nervous2.65628245
11MP0004036_abnormal_muscle_relaxation2.65041576
12MP0000749_muscle_degeneration2.49791307
13MP0006035_abnormal_mitochondrial_morpho2.48592272
14MP0005330_cardiomyopathy2.40970043
15MP0003137_abnormal_impulse_conducting2.21409928
16MP0006292_abnormal_olfactory_placode2.02226175
17MP0006072_abnormal_retinal_apoptosis1.98020379
18MP0002972_abnormal_cardiac_muscle1.97861407
19MP0004484_altered_response_of1.94760544
20MP0008877_abnormal_DNA_methylation1.92538249
21MP0004145_abnormal_muscle_electrophysio1.90087356
22MP0003011_delayed_dark_adaptation1.89762507
23MP0002736_abnormal_nociception_after1.85988137
24MP0002938_white_spotting1.85300733
25MP0002332_abnormal_exercise_endurance1.84854800
26MP0003806_abnormal_nucleotide_metabolis1.81734751
27MP0002102_abnormal_ear_morphology1.80086384
28MP0001905_abnormal_dopamine_level1.77741109
29MP0003787_abnormal_imprinting1.76085702
30MP0005620_abnormal_muscle_contractility1.75507012
31MP0001968_abnormal_touch/_nociception1.74036754
32MP0004142_abnormal_muscle_tone1.67226748
33MP0001440_abnormal_grooming_behavior1.64411647
34MP0005551_abnormal_eye_electrophysiolog1.63607304
35MP0000750_abnormal_muscle_regeneration1.62617593
36MP0008775_abnormal_heart_ventricle1.58533851
37MP0004085_abnormal_heartbeat1.58494174
38MP0009745_abnormal_behavioral_response1.58160160
39MP0004043_abnormal_pH_regulation1.56158381
40MP0002106_abnormal_muscle_physiology1.53519840
41MP0005645_abnormal_hypothalamus_physiol1.53083098
42MP0002822_catalepsy1.49452399
43MP0004130_abnormal_muscle_cell1.48045974
44MP0005646_abnormal_pituitary_gland1.47288635
45MP0004087_abnormal_muscle_fiber1.44241441
46MP0005085_abnormal_gallbladder_physiolo1.42745187
47MP0005385_cardiovascular_system_phenoty1.41648748
48MP0001544_abnormal_cardiovascular_syste1.41648748
49MP0002064_seizures1.41420026
50MP0002735_abnormal_chemical_nociception1.41268634
51MP0000631_abnormal_neuroendocrine_gland1.39907358
52MP0002272_abnormal_nervous_system1.38042353
53MP0005360_urolithiasis1.37825592
54MP0009046_muscle_twitch1.36561376
55MP0002160_abnormal_reproductive_system1.35195362
56MP0005253_abnormal_eye_physiology1.34941192
57MP0003718_maternal_effect1.33640030
58MP0008058_abnormal_DNA_repair1.32880511
59MP0003195_calcinosis1.32172049
60MP0008875_abnormal_xenobiotic_pharmacok1.32161875
61MP0003635_abnormal_synaptic_transmissio1.32150817
62MP0005535_abnormal_body_temperature1.31956520
63MP0003121_genomic_imprinting1.29234153
64MP0006138_congestive_heart_failure1.28503795
65MP0000747_muscle_weakness1.28248179
66MP0002638_abnormal_pupillary_reflex1.27109133
67MP0005386_behavior/neurological_phenoty1.25241499
68MP0004924_abnormal_behavior1.25241499
69MP0005369_muscle_phenotype1.25004799
70MP0004885_abnormal_endolymph1.23672753
71MP0005266_abnormal_metabolism1.23307517
72MP0008995_early_reproductive_senescence1.22903591
73MP0003186_abnormal_redox_activity1.21379971
74MP0003221_abnormal_cardiomyocyte_apopto1.21346763
75MP0004742_abnormal_vestibular_system1.20130326
76MP0002139_abnormal_hepatobiliary_system1.19863251
77MP0002572_abnormal_emotion/affect_behav1.18734271
78MP0002734_abnormal_mechanical_nocicepti1.17304607
79MP0002277_abnormal_respiratory_mucosa1.16619823
80MP0000759_abnormal_skeletal_muscle1.15006262
81MP0001970_abnormal_pain_threshold1.14985428
82MP0002269_muscular_atrophy1.10905820
83MP0004147_increased_porphyrin_level1.10528318
84MP0005332_abnormal_amino_acid1.09665392
85MP0004133_heterotaxia1.09193726
86MP0002067_abnormal_sensory_capabilities1.08538463
87MP0005084_abnormal_gallbladder_morpholo1.08017124
88MP0002127_abnormal_cardiovascular_syste1.07948572
89MP0008789_abnormal_olfactory_epithelium1.06591407
90MP0005389_reproductive_system_phenotype1.05402983
91MP0003122_maternal_imprinting1.04664962
92MP0002733_abnormal_thermal_nociception1.03786522
93MP0004270_analgesia1.03168740
94MP0001984_abnormal_olfaction1.02272272
95MP0001501_abnormal_sleep_pattern1.01487407
96MP0003136_yellow_coat_color1.00454755
97MP0002063_abnormal_learning/memory/cond1.00413187
98MP0000372_irregular_coat_pigmentation1.00394393
99MP0005636_abnormal_mineral_homeostasis0.99298933
100MP0001486_abnormal_startle_reflex0.97897913
101MP0002909_abnormal_adrenal_gland0.97542484
102MP0000230_abnormal_systemic_arterial0.96873138
103MP0003123_paternal_imprinting0.94834026
104MP0005165_increased_susceptibility_to0.90968809
105MP0003283_abnormal_digestive_organ0.90162525
106MP0005083_abnormal_biliary_tract0.89810107
107MP0002163_abnormal_gland_morphology0.88941710
108MP0002234_abnormal_pharynx_morphology0.88804320
109MP0008872_abnormal_physiological_respon0.87855334
110MP0003786_premature_aging0.86908992
111MP0002184_abnormal_innervation0.86245396
112MP0005584_abnormal_enzyme/coenzyme_acti0.84887548
113MP0002090_abnormal_vision0.84528368
114MP0001986_abnormal_taste_sensitivity0.83513539
115MP0001485_abnormal_pinna_reflex0.83164814
116MP0001764_abnormal_homeostasis0.82721941
117MP0004859_abnormal_synaptic_plasticity0.82176954
118MP0010386_abnormal_urinary_bladder0.80283977
119MP0001919_abnormal_reproductive_system0.79212388
120MP0002095_abnormal_skin_pigmentation0.79208789
121MP0010630_abnormal_cardiac_muscle0.79091476
122MP0002752_abnormal_somatic_nervous0.78759510
123MP0004019_abnormal_vitamin_homeostasis0.78032151
124MP0003938_abnormal_ear_development0.77652191
125MP0002876_abnormal_thyroid_physiology0.77517497
126MP0003890_abnormal_embryonic-extraembry0.77381974
127MP0000026_abnormal_inner_ear0.77010407
128MP0005376_homeostasis/metabolism_phenot0.75357981
129MP0003828_pulmonary_edema0.73975975
130MP0004233_abnormal_muscle_weight0.70275466
131MP0001664_abnormal_digestion0.70009633
132MP0005379_endocrine/exocrine_gland_phen0.69315638
133MP0002066_abnormal_motor_capabilities/c0.67137492
134MP0005171_absent_coat_pigmentation0.65477975
135MP0001188_hyperpigmentation0.63849280
136MP0005423_abnormal_somatic_nervous0.63727126
137MP0009697_abnormal_copulation0.63433794
138MP0002557_abnormal_social/conspecific_i0.63138628
139MP0000538_abnormal_urinary_bladder0.62832827
140MP0005408_hypopigmentation0.62474888

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.88850556
2Abnormal mitochondria in muscle tissue (HP:0008316)7.31278651
3Progressive macrocephaly (HP:0004481)6.79898949
4Acute encephalopathy (HP:0006846)6.74862100
5Mitochondrial inheritance (HP:0001427)6.69972840
6Increased CSF lactate (HP:0002490)5.90113700
7Hepatocellular necrosis (HP:0001404)5.60479482
8Cerebral edema (HP:0002181)5.32012951
9Hepatic necrosis (HP:0002605)5.27175383
10Increased hepatocellular lipid droplets (HP:0006565)5.19007229
11Lipid accumulation in hepatocytes (HP:0006561)4.95379767
12Increased intramyocellular lipid droplets (HP:0012240)4.67774608
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.40967704
14Exercise intolerance (HP:0003546)4.33247831
15Increased muscle lipid content (HP:0009058)4.32206185
16Lactic acidosis (HP:0003128)4.23920376
17Increased serum pyruvate (HP:0003542)4.20678914
18Abnormality of glycolysis (HP:0004366)4.20678914
19Respiratory failure (HP:0002878)4.16796401
20Renal Fanconi syndrome (HP:0001994)4.12385837
21Decreased activity of mitochondrial respiratory chain (HP:0008972)4.01224460
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.01224460
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.81880125
24* Optic disc pallor (HP:0000543)3.76772021
25Sudden death (HP:0001699)3.74566789
26Increased serum lactate (HP:0002151)3.60576523
27Leukodystrophy (HP:0002415)3.60292330
28Muscle hypertrophy of the lower extremities (HP:0008968)3.42198297
29Calf muscle hypertrophy (HP:0008981)3.34339615
303-Methylglutaconic aciduria (HP:0003535)3.33007233
31Exertional dyspnea (HP:0002875)3.23230556
32Congenital, generalized hypertrichosis (HP:0004540)3.15671628
33Abnormality of cells of the erythroid lineage (HP:0012130)3.15313036
34Respiratory difficulties (HP:0002880)3.00839700
35Conjunctival hamartoma (HP:0100780)2.96228057
36Lethargy (HP:0001254)2.93796296
37Palpitations (HP:0001962)2.90068393
38Pancreatic cysts (HP:0001737)2.74490055
39Neuroendocrine neoplasm (HP:0100634)2.71955367
40Myoglobinuria (HP:0002913)2.71672753
41Pheochromocytoma (HP:0002666)2.66571533
42Glycosuria (HP:0003076)2.66558697
43Abnormality of urine glucose concentration (HP:0011016)2.66558697
44Pancreatic fibrosis (HP:0100732)2.65675536
45Exercise-induced muscle cramps (HP:0003710)2.65503188
46Abnormality of renal resorption (HP:0011038)2.63252091
47Abnormality of midbrain morphology (HP:0002418)2.60424892
48Molar tooth sign on MRI (HP:0002419)2.60424892
49Abnormal number of erythroid precursors (HP:0012131)2.59328670
50Hyperphosphaturia (HP:0003109)2.58583428
51CNS demyelination (HP:0007305)2.56253794
52Ragged-red muscle fibers (HP:0003200)2.54290600
53* X-linked dominant inheritance (HP:0001423)2.54244992
54Myotonia (HP:0002486)2.52654722
55Exercise-induced myalgia (HP:0003738)2.50991873
56Ventricular tachycardia (HP:0004756)2.50349415
57Dicarboxylic aciduria (HP:0003215)2.45950472
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45950472
59Rhabdomyolysis (HP:0003201)2.44150790
60Emotional lability (HP:0000712)2.38559741
61Hypothermia (HP:0002045)2.36825009
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35852867
63Abnormality of alanine metabolism (HP:0010916)2.35852867
64Hyperalaninemia (HP:0003348)2.35852867
65Myokymia (HP:0002411)2.35826942
66True hermaphroditism (HP:0010459)2.35639898
67Vomiting (HP:0002013)2.35173178
68Abnormality of the calf musculature (HP:0001430)2.33593809
69Ketoacidosis (HP:0001993)2.28828578
70Medial flaring of the eyebrow (HP:0010747)2.26723175
71Nephronophthisis (HP:0000090)2.25014256
72Macrocytic anemia (HP:0001972)2.24341885
73Muscle stiffness (HP:0003552)2.19029603
74Abnormal urine phosphate concentration (HP:0012599)2.17033435
75Syncope (HP:0001279)2.16149452
76Atrial fibrillation (HP:0005110)2.13041722
77Supraventricular tachycardia (HP:0004755)2.11957141
78Primary atrial arrhythmia (HP:0001692)2.09487806
79Lipoatrophy (HP:0100578)2.08076319
80Generalized aminoaciduria (HP:0002909)2.04821410
81Congenital stationary night blindness (HP:0007642)2.04514489
82Esophageal neoplasm (HP:0100751)2.04273060
83Neoplasm of head and neck (HP:0012288)2.04273060
84Supraventricular arrhythmia (HP:0005115)2.03346186
85Methylmalonic aciduria (HP:0012120)2.02448497
86Progressive external ophthalmoplegia (HP:0000590)2.02394969
87Focal motor seizures (HP:0011153)1.96501651
88Hyperglycinemia (HP:0002154)1.96368339
89Metabolic acidosis (HP:0001942)1.93951444
90Gliosis (HP:0002171)1.92376637
91Muscle fiber splitting (HP:0003555)1.92280682
92Prolonged QT interval (HP:0001657)1.91522809
93Ketosis (HP:0001946)1.90558746
94Reticulocytopenia (HP:0001896)1.88535603
95Renal cortical cysts (HP:0000803)1.86471171
96EMG: myopathic abnormalities (HP:0003458)1.85623401
97Abnormality of the labia minora (HP:0012880)1.83942337
98Abnormality of fatty-acid metabolism (HP:0004359)1.83861805
99Type I transferrin isoform profile (HP:0003642)1.82058795
100Methylmalonic acidemia (HP:0002912)1.81789368
101Abnormality of the renal cortex (HP:0011035)1.81556881
102Cerebral hemorrhage (HP:0001342)1.81505286
103Dilated cardiomyopathy (HP:0001644)1.81176625
104Hyperventilation (HP:0002883)1.81086207
105Abnormality of serum amino acid levels (HP:0003112)1.80777282
106Pendular nystagmus (HP:0012043)1.78164108
107Abnormality of vitamin B metabolism (HP:0004340)1.78035268
108Gait imbalance (HP:0002141)1.77057072
109Renal tubular dysfunction (HP:0000124)1.76691457
110Testicular atrophy (HP:0000029)1.76668922
111Large for gestational age (HP:0001520)1.75776687
112Furrowed tongue (HP:0000221)1.74846414
113Hyperammonemia (HP:0001987)1.73362766
114Abnormal pupillary function (HP:0007686)1.72325742
115Pallor (HP:0000980)1.71663106
116Abnormality of the renal medulla (HP:0100957)1.71526903
117Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71253577
118Aplastic anemia (HP:0001915)1.70869736
119Abnormal hemoglobin (HP:0011902)1.69877375
120Limb dystonia (HP:0002451)1.69692470
121Poor suck (HP:0002033)1.69547102
122Congenital primary aphakia (HP:0007707)1.69381578
123Hypoglycemic coma (HP:0001325)1.69126985
124Blindness (HP:0000618)1.69107164
125Aplasia/hypoplasia of the uterus (HP:0008684)1.68102767
126Microvesicular hepatic steatosis (HP:0001414)1.67534080
127Abnormal gallbladder physiology (HP:0012438)1.66146417
128Cholecystitis (HP:0001082)1.66146417
129Septo-optic dysplasia (HP:0100842)1.62480750
130Concave nail (HP:0001598)1.61758973
131Broad-based gait (HP:0002136)1.60649834
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60112945
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.58274835
134Absent thumb (HP:0009777)1.58128557
135Hyperinsulinemic hypoglycemia (HP:0000825)1.55024712
136Type II lissencephaly (HP:0007260)1.53873526
137Nephrogenic diabetes insipidus (HP:0009806)1.53086096
138Abolished electroretinogram (ERG) (HP:0000550)1.49475202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.79411298
2MAP3K123.75877629
3NME13.73201729
4MYLK3.56324012
5OBSCN2.96186015
6VRK22.91482320
7GRK52.77891236
8ZAK2.63836044
9FRK2.54984987
10GRK72.48690351
11BCKDK2.48090807
12ARAF2.35586202
13BUB12.14781114
14MUSK2.11816464
15CASK2.04361465
16PDK32.02376743
17PDK42.02376743
18MAP2K72.00072139
19MAP3K41.94243819
20PHKG21.90283574
21PHKG11.90283574
22WNK41.89089023
23BMPR1B1.88038135
24LIMK11.79353408
25MAP4K21.75207506
26MST41.74562400
27GRK11.74433185
28STK161.68538602
29MAP2K41.67891331
30PNCK1.67836283
31STK391.66508014
32LMTK21.51442974
33CDC71.49962865
34RIPK41.47349391
35TLK11.45327878
36TTN1.37796520
37OXSR11.36820542
38NUAK11.36706396
39NTRK31.33034848
40EPHA41.28789854
41DAPK31.27580891
42PIK3CA1.25571943
43PDK21.20116219
44PBK1.19304201
45CAMK2D1.17201066
46CDK191.11215504
47CSNK1G21.10950936
48CAMK2A1.10895040
49PLK31.10819122
50INSRR1.09522676
51ILK1.06647919
52ADRBK21.04988867
53GRK61.04779675
54ABL21.03884048
55ADRBK11.03309690
56ACVR1B1.02721143
57PLK21.02634711
58EIF2AK10.99251323
59PINK10.95706110
60CSNK1G10.94430878
61PLK40.94108254
62BRAF0.92427186
63VRK10.92314897
64MINK10.92116886
65NEK10.90515108
66TAF10.89940997
67PIM20.88644092
68STK240.88045773
69CAMK2G0.87048924
70CAMK2B0.86479539
71PTK2B0.86069181
72BMPR20.85758378
73PLK10.82581166
74MST1R0.80070486
75DYRK30.78901119
76FGR0.78897652
77MAPK120.78882536
78WNK30.76933451
79CSNK1A1L0.74505295
80ERBB30.73291481
81ROCK20.72820977
82PRKACA0.72808105
83MKNK20.72468460
84PAK30.68136611
85BRSK20.67554050
86CCNB10.67224850
87RPS6KA50.64879148
88MAPK130.62473634
89TTK0.61381057
90DAPK10.60994895
91PRKCE0.60983201
92TNIK0.58601979
93TRIM280.57595378
94MKNK10.56579692
95EIF2AK30.54696706
96AURKB0.54692874
97BCR0.53767116
98MAP3K110.52856255
99MAP2K60.52532675
100DAPK20.52292478
101CHEK20.52128602
102PRKCG0.48863074
103ROCK10.48576132
104MARK10.48223936
105TIE10.47327942
106UHMK10.47225411
107MAPKAPK50.47060949
108MAPKAPK30.45286538
109CSNK1A10.44948175
110CSNK1E0.44817286
111WEE10.43920091
112MAP3K90.43267235
113PRKG10.43099655
114MAPK40.40734657
115MOS0.40204986
116CSNK2A20.39930317
117TSSK60.39742363
118PKN10.38108948
119CDK140.37548533
120KDR0.37072737
121CDK80.36356570
122CSNK2A10.36212056
123ATR0.35626994
124DYRK20.35216659
125ERBB40.34483967
126PRKACG0.33962004
127AURKA0.33270836
128MAP2K10.33147232
129CAMK10.32993412
130KSR20.32937770
131SRPK10.32512902
132CDK50.32411766
133RAF10.31949693
134MAP3K50.30666655
135CSNK1G30.29954375
136PRKCA0.29391373
137FES0.28996072

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.65476795
2Parkinsons disease_Homo sapiens_hsa050125.79344519
3Alzheimers disease_Homo sapiens_hsa050104.42472295
4Huntingtons disease_Homo sapiens_hsa050163.97980585
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.71257243
6* Cardiac muscle contraction_Homo sapiens_hsa042603.53772771
7Ribosome_Homo sapiens_hsa030103.49786371
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.44184848
9Proteasome_Homo sapiens_hsa030502.14088300
10Propanoate metabolism_Homo sapiens_hsa006402.07980839
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00150291
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95251490
13Pyruvate metabolism_Homo sapiens_hsa006201.79785809
14Homologous recombination_Homo sapiens_hsa034401.69653030
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60892503
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57559027
17Collecting duct acid secretion_Homo sapiens_hsa049661.56967325
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54976386
19Carbon metabolism_Homo sapiens_hsa012001.54062449
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48200878
21Protein export_Homo sapiens_hsa030601.45848805
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.45538724
23Sulfur metabolism_Homo sapiens_hsa009201.40686224
24Mismatch repair_Homo sapiens_hsa034301.40615589
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40340413
26Fatty acid elongation_Homo sapiens_hsa000621.36840489
27Butanoate metabolism_Homo sapiens_hsa006501.35937563
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33758986
29Fatty acid degradation_Homo sapiens_hsa000711.23816712
30Nitrogen metabolism_Homo sapiens_hsa009101.21647435
31RNA polymerase_Homo sapiens_hsa030201.19411097
32Basal transcription factors_Homo sapiens_hsa030221.18251869
33RNA degradation_Homo sapiens_hsa030181.15626021
34DNA replication_Homo sapiens_hsa030301.13818817
35Nucleotide excision repair_Homo sapiens_hsa034201.03387410
36Phenylalanine metabolism_Homo sapiens_hsa003600.94721563
37Nicotine addiction_Homo sapiens_hsa050330.89902588
38Fatty acid metabolism_Homo sapiens_hsa012120.89597915
39Spliceosome_Homo sapiens_hsa030400.89293623
40Tyrosine metabolism_Homo sapiens_hsa003500.88313926
41Fanconi anemia pathway_Homo sapiens_hsa034600.88042903
42One carbon pool by folate_Homo sapiens_hsa006700.86998297
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86616634
44* Metabolic pathways_Homo sapiens_hsa011000.85795731
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85188298
46Vibrio cholerae infection_Homo sapiens_hsa051100.82749905
47Peroxisome_Homo sapiens_hsa041460.78534150
48Selenocompound metabolism_Homo sapiens_hsa004500.69954914
49Dilated cardiomyopathy_Homo sapiens_hsa054140.69527741
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68523754
51Synaptic vesicle cycle_Homo sapiens_hsa047210.67092258
52RNA transport_Homo sapiens_hsa030130.65466436
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65198056
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64802219
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64309365
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63983535
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63063728
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62625186
59Tryptophan metabolism_Homo sapiens_hsa003800.61746877
60beta-Alanine metabolism_Homo sapiens_hsa004100.61451616
61Retinol metabolism_Homo sapiens_hsa008300.60773499
62Taste transduction_Homo sapiens_hsa047420.60717748
63Pyrimidine metabolism_Homo sapiens_hsa002400.60449165
64Biosynthesis of amino acids_Homo sapiens_hsa012300.59885287
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.59641869
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59590641
67Glutathione metabolism_Homo sapiens_hsa004800.59265516
68Caffeine metabolism_Homo sapiens_hsa002320.58454777
69Mineral absorption_Homo sapiens_hsa049780.56381433
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55663387
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.53799456
72Arginine and proline metabolism_Homo sapiens_hsa003300.52640141
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51670781
74Regulation of autophagy_Homo sapiens_hsa041400.51569792
75Serotonergic synapse_Homo sapiens_hsa047260.51318349
76Chemical carcinogenesis_Homo sapiens_hsa052040.49722145
77Ether lipid metabolism_Homo sapiens_hsa005650.47711546
78GABAergic synapse_Homo sapiens_hsa047270.47044084
79Base excision repair_Homo sapiens_hsa034100.46535117
80PPAR signaling pathway_Homo sapiens_hsa033200.45144408
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45019339
82Steroid biosynthesis_Homo sapiens_hsa001000.44497755
83Calcium signaling pathway_Homo sapiens_hsa040200.44494534
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44272664
85Sulfur relay system_Homo sapiens_hsa041220.44174602
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43214319
87Arginine biosynthesis_Homo sapiens_hsa002200.41142816
88Fructose and mannose metabolism_Homo sapiens_hsa000510.39293674
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39106731
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38953169
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37997073
92Starch and sucrose metabolism_Homo sapiens_hsa005000.36601837
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.35861047
94Histidine metabolism_Homo sapiens_hsa003400.35694731
95Vitamin digestion and absorption_Homo sapiens_hsa049770.35082425
96Renin secretion_Homo sapiens_hsa049240.33937040
97Purine metabolism_Homo sapiens_hsa002300.33490508
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32573417
99Vitamin B6 metabolism_Homo sapiens_hsa007500.32056492
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31259107
101Amphetamine addiction_Homo sapiens_hsa050310.30230535
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.30159342
103Folate biosynthesis_Homo sapiens_hsa007900.29569273
104Circadian entrainment_Homo sapiens_hsa047130.29331260
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29299723
106Long-term potentiation_Homo sapiens_hsa047200.28993352
107Fat digestion and absorption_Homo sapiens_hsa049750.28476958
108Morphine addiction_Homo sapiens_hsa050320.27969160
109Salivary secretion_Homo sapiens_hsa049700.27208843
110Dopaminergic synapse_Homo sapiens_hsa047280.26923818
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.24474201
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24268102
113Phototransduction_Homo sapiens_hsa047440.23898179
114Glutamatergic synapse_Homo sapiens_hsa047240.23811099
115Gastric acid secretion_Homo sapiens_hsa049710.23710932
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23437903
117Arachidonic acid metabolism_Homo sapiens_hsa005900.22184223
118Galactose metabolism_Homo sapiens_hsa000520.21841294
119Rheumatoid arthritis_Homo sapiens_hsa053230.21708731
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21500164
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18976157
122Linoleic acid metabolism_Homo sapiens_hsa005910.18681749
123Olfactory transduction_Homo sapiens_hsa047400.16796605
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15959968
125Glucagon signaling pathway_Homo sapiens_hsa049220.15749587
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15579105
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.15003275
128Pentose phosphate pathway_Homo sapiens_hsa000300.14842449
129Oxytocin signaling pathway_Homo sapiens_hsa049210.14513137
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.14124524
131Long-term depression_Homo sapiens_hsa047300.11654323
132Insulin secretion_Homo sapiens_hsa049110.10616330

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