COX7B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.97012822
2synaptonemal complex organization (GO:0070193)9.81993067
3synaptonemal complex assembly (GO:0007130)9.81620685
4axonemal dynein complex assembly (GO:0070286)9.54695834
5binding of sperm to zona pellucida (GO:0007339)9.49296975
6cell-cell recognition (GO:0009988)9.33497949
7epithelial cilium movement (GO:0003351)8.97100121
8reproduction (GO:0000003)8.55625239
9acrosome reaction (GO:0007340)8.55358869
10spermatid development (GO:0007286)8.32061371
11motile cilium assembly (GO:0044458)8.30701938
12DNA methylation involved in gamete generation (GO:0043046)8.26132480
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.24347755
14cilium movement (GO:0003341)7.72968417
15chromosome organization involved in meiosis (GO:0070192)6.98474155
16single fertilization (GO:0007338)6.79967691
17male meiosis I (GO:0007141)6.76730086
18regulation of cilium movement (GO:0003352)6.64830221
19meiotic nuclear division (GO:0007126)6.49980500
20negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.48599671
21fertilization (GO:0009566)6.05232992
22regulation of retinoic acid receptor signaling pathway (GO:0048385)5.93157605
23sperm capacitation (GO:0048240)5.81338602
24spermatogenesis (GO:0007283)5.62519370
25male gamete generation (GO:0048232)5.60898793
26meiosis I (GO:0007127)5.55617705
27germ cell development (GO:0007281)5.20548099
28proteasome assembly (GO:0043248)5.19442068
29microtubule depolymerization (GO:0007019)5.19166874
30gamete generation (GO:0007276)5.17225042
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.12451672
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.04116263
33ventricular system development (GO:0021591)4.87856091
34chaperone-mediated protein transport (GO:0072321)4.86099523
35negative regulation of inclusion body assembly (GO:0090084)4.81653549
36gene silencing by RNA (GO:0031047)4.63710926
37regulation of meiosis I (GO:0060631)4.57617944
38meiotic cell cycle (GO:0051321)4.55902578
39cell recognition (GO:0008037)4.42784047
40monoubiquitinated protein deubiquitination (GO:0035520)4.31162115
41meiotic cell cycle process (GO:1903046)4.29959951
42ATP synthesis coupled proton transport (GO:0015986)4.29632347
43energy coupled proton transport, down electrochemical gradient (GO:0015985)4.29632347
44seminiferous tubule development (GO:0072520)4.28372663
45regulation of inclusion body assembly (GO:0090083)4.17317844
46establishment of protein localization to mitochondrial membrane (GO:0090151)4.14969702
47organic cation transport (GO:0015695)4.12545177
48rRNA modification (GO:0000154)4.08653341
49protein localization to cilium (GO:0061512)4.07637244
50synapsis (GO:0007129)4.06790216
51phenylpropanoid metabolic process (GO:0009698)4.04214786
52multicellular organismal reproductive process (GO:0048609)4.02726016
53calcium ion-dependent exocytosis (GO:0017156)4.00405596
54microtubule severing (GO:0051013)3.99276458
55maturation of SSU-rRNA (GO:0030490)3.98354745
56genitalia morphogenesis (GO:0035112)3.95384795
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92657481
58regulation of microtubule-based movement (GO:0060632)3.91558148
59gonadal mesoderm development (GO:0007506)3.91522761
60spermatid nucleus differentiation (GO:0007289)3.86037037
61chaperone-mediated protein complex assembly (GO:0051131)3.81224695
62ribosomal large subunit biogenesis (GO:0042273)3.79842286
63regulation of cellular amino acid metabolic process (GO:0006521)3.78433590
64transcription from mitochondrial promoter (GO:0006390)3.78192607
65ribosomal small subunit biogenesis (GO:0042274)3.74877771
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.73693373
67respiratory electron transport chain (GO:0022904)3.68693380
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.68155022
69respiratory chain complex IV assembly (GO:0008535)3.66072271
70mitochondrial respiratory chain complex assembly (GO:0033108)3.65319882
71intraciliary transport (GO:0042073)3.64295452
72regulation of centriole replication (GO:0046599)3.62756985
73electron transport chain (GO:0022900)3.62560193
74pseudouridine synthesis (GO:0001522)3.60406494
75ribosomal small subunit assembly (GO:0000028)3.60250099
76protein complex biogenesis (GO:0070271)3.58481742
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56167866
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.52983559
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51751222
80nuclear pore complex assembly (GO:0051292)3.51389693
81protein targeting to mitochondrion (GO:0006626)3.45247738
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39455166
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.37917861
84NADH dehydrogenase complex assembly (GO:0010257)3.37917861
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37917861
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37306771
87negative regulation of ligase activity (GO:0051352)3.37306771
88positive regulation of ligase activity (GO:0051351)3.34077578
89ribosome assembly (GO:0042255)3.33126804
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33040251
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33040251
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33040251
93maturation of 5.8S rRNA (GO:0000460)3.32838930
94mitochondrial RNA metabolic process (GO:0000959)3.32151424
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31169217
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31169217
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30642867
98cullin deneddylation (GO:0010388)3.29435770
99DNA alkylation (GO:0006305)3.28735310
100DNA methylation (GO:0006306)3.28735310
101left/right pattern formation (GO:0060972)3.27793615
102termination of RNA polymerase III transcription (GO:0006386)3.27070899
103transcription elongation from RNA polymerase III promoter (GO:0006385)3.27070899
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24539472
105protein deneddylation (GO:0000338)3.23814412
106centriole replication (GO:0007099)3.23337755
107establishment of protein localization to mitochondrion (GO:0072655)3.23232500
108axoneme assembly (GO:0035082)3.23184015
109protein polyglutamylation (GO:0018095)3.21835410
110signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21333522
111signal transduction involved in DNA damage checkpoint (GO:0072422)3.21333522
112multicellular organismal development (GO:0007275)3.20827560
113negative regulation of organelle assembly (GO:1902116)3.19861143
114signal transduction involved in cell cycle checkpoint (GO:0072395)3.18453573
115gene silencing (GO:0016458)3.18367419
116protein K11-linked deubiquitination (GO:0035871)3.18350599
117translation (GO:0006412)3.17932727
118sister chromatid cohesion (GO:0007062)3.17707571
119rRNA processing (GO:0006364)3.17658360
120cytochrome complex assembly (GO:0017004)3.17172676
121rRNA methylation (GO:0031167)3.14719150
122protein localization to mitochondrion (GO:0070585)3.12824954
123translational termination (GO:0006415)3.11308130
124regulation of spindle checkpoint (GO:0090231)3.11104976
125viral transcription (GO:0019083)3.09389479
126regulation of protein polyubiquitination (GO:1902914)3.08835588
127protein K6-linked ubiquitination (GO:0085020)3.07614324
128rRNA metabolic process (GO:0016072)3.06963004
129glyoxylate metabolic process (GO:0046487)3.06905913
130glycerol ether metabolic process (GO:0006662)3.06609210
131centriole assembly (GO:0098534)3.05898193
132SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04958061
133microtubule-based movement (GO:0007018)3.04012849
134cotranslational protein targeting to membrane (GO:0006613)3.03814487
135protein-cofactor linkage (GO:0018065)3.03371812
136cellular component biogenesis (GO:0044085)3.02593640
137oxidative phosphorylation (GO:0006119)3.02127084
138regulation of ubiquitin-protein transferase activity (GO:0051438)3.01127894
139mannosylation (GO:0097502)3.01090952
140DNA packaging (GO:0006323)3.00037940
141nuclear pore organization (GO:0006999)2.98636254
142regulation of mitochondrial translation (GO:0070129)2.96848466
143protein targeting to ER (GO:0045047)2.96078990
144chromosome condensation (GO:0030261)2.90544049
145histone exchange (GO:0043486)2.90468604
146translational initiation (GO:0006413)2.88437283
147ribonucleoprotein complex biogenesis (GO:0022613)2.87816213
148regulation of cellular amine metabolic process (GO:0033238)2.87783203
149regulation of ligase activity (GO:0051340)2.87472138
150protein localization to endoplasmic reticulum (GO:0070972)2.86891596
151reciprocal meiotic recombination (GO:0007131)2.85291289
152reciprocal DNA recombination (GO:0035825)2.85291289
153establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85272850
154formation of translation preinitiation complex (GO:0001731)2.85120304
155cilium organization (GO:0044782)2.85104141
156glycine metabolic process (GO:0006544)2.84975837
157translational elongation (GO:0006414)2.84559095
158serine family amino acid catabolic process (GO:0009071)2.83695358
159mitotic sister chromatid cohesion (GO:0007064)2.83427772
160ATP biosynthetic process (GO:0006754)2.82957422
161lactate metabolic process (GO:0006089)2.82320965
162ether metabolic process (GO:0018904)2.82006123
163establishment of integrated proviral latency (GO:0075713)2.80436238
164C-terminal protein lipidation (GO:0006501)2.77734671
165negative regulation of DNA repair (GO:0045738)2.77588508
166nucleoside diphosphate phosphorylation (GO:0006165)2.75673446
167alditol metabolic process (GO:0019400)2.74249765
168cilium morphogenesis (GO:0060271)2.74214163
169flavonoid metabolic process (GO:0009812)2.72954749
170GTP biosynthetic process (GO:0006183)2.72746489
171microtubule polymerization or depolymerization (GO:0031109)2.72326404
172intracellular protein transmembrane import (GO:0044743)2.71693674
173amino-acid betaine transport (GO:0015838)2.71501641
174carnitine transport (GO:0015879)2.71501641
175cilium assembly (GO:0042384)2.70732744
176single strand break repair (GO:0000012)2.69945420
177oxidative demethylation (GO:0070989)2.69695440
178carnitine transmembrane transport (GO:1902603)2.69683446
179water-soluble vitamin biosynthetic process (GO:0042364)2.69328361
180pore complex assembly (GO:0046931)2.68475662
181tRNA processing (GO:0008033)2.67294437
182cellular component assembly involved in morphogenesis (GO:0010927)2.67065983
183C-terminal protein amino acid modification (GO:0018410)2.65672047
184mitotic metaphase plate congression (GO:0007080)2.64894075
185mitochondrial transport (GO:0006839)2.64537360
186RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.61323325
187regulation of oxidative phosphorylation (GO:0002082)2.61253620
188preassembly of GPI anchor in ER membrane (GO:0016254)2.61174314
189cilium or flagellum-dependent cell motility (GO:0001539)13.3540042
190fusion of sperm to egg plasma membrane (GO:0007342)13.1562271
191piRNA metabolic process (GO:0034587)12.1374295
192acrosome assembly (GO:0001675)11.2585180
193cell wall macromolecule metabolic process (GO:0044036)10.5786969
194cell wall macromolecule catabolic process (GO:0016998)10.5786969
195multicellular organism reproduction (GO:0032504)10.5506845
196sperm motility (GO:0030317)10.4933196
197sperm-egg recognition (GO:0035036)10.4422902
198male meiosis (GO:0007140)10.1519989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.17916298
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.74532862
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.63738184
4EZH2_22144423_ChIP-Seq_EOC_Human4.22293890
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.18525669
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.88756129
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.83824486
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.54335122
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.52155201
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42335823
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05179951
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02886667
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.02619336
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01030816
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67943261
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64847425
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.60217532
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59433281
19ELK1_19687146_ChIP-ChIP_HELA_Human2.46450891
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43276396
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.42224464
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42113930
23VDR_23849224_ChIP-Seq_CD4+_Human2.40373155
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.36611913
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35025840
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33736789
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31847902
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.31406380
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28335343
30FOXP3_21729870_ChIP-Seq_TREG_Human2.16262345
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14364751
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11252226
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00716962
34GABP_19822575_ChIP-Seq_HepG2_Human2.00567108
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse12.0745122
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97250729
37ZNF274_21170338_ChIP-Seq_K562_Hela1.97156791
38TTF2_22483619_ChIP-Seq_HELA_Human1.97086153
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96716191
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95984618
41DCP1A_22483619_ChIP-Seq_HELA_Human1.89372092
42E2F7_22180533_ChIP-Seq_HELA_Human1.87732184
43KAP1_22055183_ChIP-Seq_ESCs_Mouse1.83754994
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83135209
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.82759041
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.82010896
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81627835
48KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.81150279
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78879262
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77256878
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.74970636
52ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74135946
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.73340843
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73247586
55XRN2_22483619_ChIP-Seq_HELA_Human1.72310299
56MYC_18940864_ChIP-ChIP_HL60_Human1.64824326
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62315038
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61771537
59TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60419921
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58121919
61* CBX2_27304074_Chip-Seq_ESCs_Mouse1.57639098
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.55914527
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55488698
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55455650
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54065585
66VDR_22108803_ChIP-Seq_LS180_Human1.52819743
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50613831
68AR_21909140_ChIP-Seq_LNCAP_Human1.49824755
69RNF2_27304074_Chip-Seq_NSC_Mouse1.49311570
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48677605
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47896172
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46947738
73STAT1_17558387_ChIP-Seq_HELA_Human1.46805363
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44948288
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.43225014
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.40294386
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39052179
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38961529
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37019956
80ZNF263_19887448_ChIP-Seq_K562_Human1.36684907
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.36663238
82GATA3_21867929_ChIP-Seq_CD8_Mouse1.36054327
83FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31235307
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29439093
85KDM5A_27292631_Chip-Seq_BREAST_Human1.26148547
86SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25128068
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23501946
88* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22366507
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21195505
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21018785
91SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.20181111
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.20042502
93IRF1_19129219_ChIP-ChIP_H3396_Human1.19779777
94* GATA3_21867929_ChIP-Seq_TH1_Mouse1.19273430
95KDM2B_26808549_Chip-Seq_REH_Human1.19082294
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.18474940
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.17916648
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17779242
99LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16093177
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15829377
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.14894026
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14130489
103IGF1R_20145208_ChIP-Seq_DFB_Human1.13594047
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.13475431
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.12740708
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12089016
107CBP_20019798_ChIP-Seq_JUKART_Human1.12089016
108HTT_18923047_ChIP-ChIP_STHdh_Human1.12006722
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11872157
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.11233359
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11219033
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10096379
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08600313
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08548383
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.07964659
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07864397
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07179117
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.06914813
119P300_18555785_Chip-Seq_ESCs_Mouse1.05590032
120ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04363321
121P53_22387025_ChIP-Seq_ESCs_Mouse1.04135294
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04010822
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03870259
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03156501
125STAT3_18555785_Chip-Seq_ESCs_Mouse1.02920939
126CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01105001
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.00332339
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97950219
129NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97488075
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96677005
131REST_21632747_ChIP-Seq_MESCs_Mouse0.96520171
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96508695
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96508695
134LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96477056
135TP53_22573176_ChIP-Seq_HFKS_Human0.96377328
136P53_21459846_ChIP-Seq_SAOS-2_Human0.96190732
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.95911921
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95647336
139E2F1_21310950_ChIP-Seq_MCF-7_Human0.95609616
140CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95230653
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95016327
142GF1_26923725_Chip-Seq_HPCs_Mouse0.94073967
143FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93246969
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.93107612
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92254156
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90785565
147PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88781585
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88654623
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88497338
150SPI1_26923725_Chip-Seq_HPCs_Mouse0.88445395
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88410406
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.88045454
153AR_20517297_ChIP-Seq_VCAP_Human0.87924743
154E2F1_18555785_Chip-Seq_ESCs_Mouse0.87924413
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.87583085
156ELF5_23300383_ChIP-Seq_T47D_Human0.87058388
157RARA_24833708_ChIP-Seq_LIVER_Mouse0.86966314
158CTCF_18555785_Chip-Seq_ESCs_Mouse0.86948585
159ZFX_18555785_Chip-Seq_ESCs_Mouse0.85634103
160PU1_27457419_Chip-Seq_LIVER_Mouse0.85499349
161PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85207360
162SOX9_26525672_Chip-Seq_HEART_Mouse0.84709155
163SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84662254
164FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84272469
165SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84243175
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84220831
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84198783
168SOX2_19829295_ChIP-Seq_ESCs_Human0.83909617
169NANOG_19829295_ChIP-Seq_ESCs_Human0.83909617
170CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82990509
171FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82256279
172FOXA1_25329375_ChIP-Seq_VCAP_Human0.82256279
173EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82076296
174RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81824579
175SOX17_20123909_ChIP-Seq_XEN_Mouse0.81824511
176NCOR_22424771_ChIP-Seq_293T_Human0.79014887
177SOX2_16153702_ChIP-ChIP_HESCs_Human0.77890708
178EWS_26573619_Chip-Seq_HEK293_Human0.77838373
179CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77413600
180ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77198557
181ER_23166858_ChIP-Seq_MCF-7_Human0.75329841
182CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75175501
183ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73726507
184PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73527656
185CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72788067
186RBPJ_21746931_ChIP-Seq_IB4_Human0.71964254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.31401592
2MP0003698_abnormal_male_reproductive5.83957211
3MP0001929_abnormal_gametogenesis5.68304073
4MP0002210_abnormal_sex_determination4.45065072
5MP0003806_abnormal_nucleotide_metabolis4.34954231
6MP0001145_abnormal_male_reproductive3.72999768
7MP0005360_urolithiasis3.58730728
8MP0009697_abnormal_copulation3.47801254
9MP0002138_abnormal_hepatobiliary_system3.40599941
10MP0000653_abnormal_sex_gland3.26274305
11MP0002161_abnormal_fertility/fecundity3.15148728
12MP0002653_abnormal_ependyma_morphology3.11528438
13MP0008057_abnormal_DNA_replication2.95913894
14MP0003718_maternal_effect2.86228106
15MP0008875_abnormal_xenobiotic_pharmacok2.73172834
16MP0005085_abnormal_gallbladder_physiolo2.53576540
17MP0003186_abnormal_redox_activity2.50049861
18MP0002938_white_spotting2.47514690
19MP0008058_abnormal_DNA_repair2.41149011
20MP0003195_calcinosis2.37632186
21MP0002876_abnormal_thyroid_physiology2.35401411
22MP0008995_early_reproductive_senescence2.28132985
23MP0010094_abnormal_chromosome_stability2.20070435
24MP0005408_hypopigmentation2.01094026
25MP0005410_abnormal_fertilization13.0829436
26MP0002139_abnormal_hepatobiliary_system1.99856877
27MP0003786_premature_aging1.98903187
28MP0005623_abnormal_meninges_morphology1.98272308
29MP0002160_abnormal_reproductive_system1.97860908
30MP0003136_yellow_coat_color1.95601196
31MP0009379_abnormal_foot_pigmentation1.91854577
32MP0005365_abnormal_bile_salt1.90499531
33MP0002638_abnormal_pupillary_reflex1.78004343
34MP0010030_abnormal_orbit_morphology1.66147372
35MP0008872_abnormal_physiological_respon1.61013762
36MP0001986_abnormal_taste_sensitivity1.56171989
37MP0001529_abnormal_vocalization1.51598784
38MP0005670_abnormal_white_adipose1.50672514
39MP0008789_abnormal_olfactory_epithelium1.47272188
40MP0003252_abnormal_bile_duct1.46613575
41MP0000372_irregular_coat_pigmentation1.44114757
42MP0001968_abnormal_touch/_nociception1.37529193
43MP0005332_abnormal_amino_acid1.37170487
44MP0005423_abnormal_somatic_nervous1.35961118
45MP0008007_abnormal_cellular_replicative1.35854249
46MP0002736_abnormal_nociception_after1.32602424
47MP0005084_abnormal_gallbladder_morpholo1.29265345
48MP0002090_abnormal_vision1.28122195
49MP0003111_abnormal_nucleus_morphology1.24850102
50MP0003646_muscle_fatigue1.22610990
51MP0005647_abnormal_sex_gland1.22340335
52MP0009046_muscle_twitch1.21094530
53MP0003868_abnormal_feces_composition1.18095757
54MP0005395_other_phenotype1.16987363
55MP0004233_abnormal_muscle_weight1.15826019
56MP0009840_abnormal_foam_cell1.15605051
57MP0005646_abnormal_pituitary_gland1.10826643
58MP0004147_increased_porphyrin_level1.08847411
59MP0010386_abnormal_urinary_bladder1.06608131
60MP0006292_abnormal_olfactory_placode1.05757206
61MP0002282_abnormal_trachea_morphology1.05148223
62MP0005389_reproductive_system_phenotype1.04971488
63MP0001984_abnormal_olfaction1.02566053
64MP0008260_abnormal_autophagy1.01536590
65MP0005367_renal/urinary_system_phenotyp0.98000963
66MP0000516_abnormal_urinary_system0.98000963
67MP0003077_abnormal_cell_cycle0.94543026
68MP0001666_abnormal_nutrient_absorption0.93370690
69MP0003938_abnormal_ear_development0.92618997
70MP0010307_abnormal_tumor_latency0.90251524
71MP0006276_abnormal_autonomic_nervous0.89765311
72MP0005499_abnormal_olfactory_system0.88280640
73MP0005394_taste/olfaction_phenotype0.88280640
74MP0004742_abnormal_vestibular_system0.87229615
75MP0005319_abnormal_enzyme/_coenzyme0.86454589
76MP0003315_abnormal_perineum_morphology0.85819014
77MP0001119_abnormal_female_reproductive0.85627035
78MP0002272_abnormal_nervous_system0.81700349
79MP0001905_abnormal_dopamine_level0.76839451
80MP0003011_delayed_dark_adaptation0.75481937
81MP0001730_embryonic_growth_arrest0.75286451
82MP0004142_abnormal_muscle_tone0.72973284
83MP0005187_abnormal_penis_morphology0.72234138
84MP0004957_abnormal_blastocyst_morpholog0.71677593
85MP0009745_abnormal_behavioral_response0.71614448
86MP0000631_abnormal_neuroendocrine_gland0.71442031
87MP0000383_abnormal_hair_follicle0.70761499
88MP0002295_abnormal_pulmonary_circulatio0.69812453
89MP0003699_abnormal_female_reproductive0.69798743
90MP0004808_abnormal_hematopoietic_stem0.67587194
91MP0003878_abnormal_ear_physiology0.67332798
92MP0005377_hearing/vestibular/ear_phenot0.67332798
93MP0003880_abnormal_central_pattern0.66765049
94MP0000358_abnormal_cell_content/0.66022245
95MP0001765_abnormal_ion_homeostasis0.62458685
96MP0000049_abnormal_middle_ear0.62350470
97MP0003693_abnormal_embryo_hatching0.62009673
98MP0003943_abnormal_hepatobiliary_system0.61997393
99MP0005376_homeostasis/metabolism_phenot0.59274232
100MP0005379_endocrine/exocrine_gland_phen0.58890034
101MP0001293_anophthalmia0.57591598
102MP0003890_abnormal_embryonic-extraembry0.57302849
103MP0002234_abnormal_pharynx_morphology0.55347666
104MP0002102_abnormal_ear_morphology0.53915236
105MP0000313_abnormal_cell_death0.52492824
106MP0004134_abnormal_chest_morphology0.51733359
107MP0005253_abnormal_eye_physiology0.50355081
108MP0008932_abnormal_embryonic_tissue0.49392744
109MP0002084_abnormal_developmental_patter0.47562808
110MP0001672_abnormal_embryogenesis/_devel0.45340583
111MP0005380_embryogenesis_phenotype0.45340583
112MP0001697_abnormal_embryo_size0.45241342
113MP0000427_abnormal_hair_cycle0.43902014
114MP0005391_vision/eye_phenotype0.43476639
115MP0006036_abnormal_mitochondrial_physio0.42160630
116MP0004036_abnormal_muscle_relaxation0.42098928
117MP0002269_muscular_atrophy0.42093494
118MP0000569_abnormal_digit_pigmentation0.41197325
119MP0005551_abnormal_eye_electrophysiolog0.41123941
120MP0003984_embryonic_growth_retardation0.38689951
121MP0003123_paternal_imprinting0.38664838
122MP0001545_abnormal_hematopoietic_system0.37657910
123MP0005397_hematopoietic_system_phenotyp0.37657910
124MP0004197_abnormal_fetal_growth/weight/0.36166657
125MP0002085_abnormal_embryonic_tissue0.35510127
126MP0000647_abnormal_sebaceous_gland0.35008693
127MP0002088_abnormal_embryonic_growth/wei0.34791490
128MP0001324_abnormal_eye_pigmentation0.33989141
129MP0004019_abnormal_vitamin_homeostasis0.33445752
130MP0003861_abnormal_nervous_system0.33389097
131MP0002080_prenatal_lethality0.33207212
132MP0006035_abnormal_mitochondrial_morpho0.33110844
133MP0003950_abnormal_plasma_membrane0.32929282
134MP0003936_abnormal_reproductive_system0.32321546
135MP0002092_abnormal_eye_morphology0.28938554
136MP0001764_abnormal_homeostasis0.28516677
137MP0003115_abnormal_respiratory_system0.27172999
138MP0006072_abnormal_retinal_apoptosis0.26972419
139MP0001727_abnormal_embryo_implantation0.26275076
140MP0000350_abnormal_cell_proliferation0.26142033
141MP0005076_abnormal_cell_differentiation0.25825249
142MP0000432_abnormal_head_morphology0.25110035
143MP0009278_abnormal_bone_marrow0.24195965
144MP0002152_abnormal_brain_morphology0.24123908
145MP0002928_abnormal_bile_duct0.23192767
146MP0004133_heterotaxia0.22850947
147MP0005666_abnormal_adipose_tissue0.22090618
148MP0001661_extended_life_span0.21839560
149MP0005636_abnormal_mineral_homeostasis0.21678779
150MP0002971_abnormal_brown_adipose0.21670283
151MP0004084_abnormal_cardiac_muscle0.21643078
152MP0009703_decreased_birth_body0.19886436
153MP0002233_abnormal_nose_morphology0.19832356
154MP0002009_preneoplasia0.19814052
155MP0006138_congestive_heart_failure0.19473876
156MP0002019_abnormal_tumor_incidence0.18787260
157MP0009115_abnormal_fat_cell0.18523914
158MP0001919_abnormal_reproductive_system0.17393475
159MP0003631_nervous_system_phenotype0.16973596
160MP0005266_abnormal_metabolism0.15716738
161MP0002970_abnormal_white_adipose0.15411556

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.26074622
2Abnormal respiratory motile cilium morphology (HP:0005938)8.62380795
3Abnormal respiratory epithelium morphology (HP:0012253)8.62380795
4Rhinitis (HP:0012384)7.83735991
5Abnormal ciliary motility (HP:0012262)7.63142115
6Chronic bronchitis (HP:0004469)7.23159177
7Nasal polyposis (HP:0100582)5.89950250
8Infertility (HP:0000789)5.79602319
9Abnormality of the nasal mucosa (HP:0000433)4.76739729
10Acute necrotizing encephalopathy (HP:0006965)4.68864577
11Reduced antithrombin III activity (HP:0001976)4.61053632
12Acute encephalopathy (HP:0006846)4.44493836
13Bronchiectasis (HP:0002110)4.39885784
14Abnormal mitochondria in muscle tissue (HP:0008316)4.36399295
15Nephronophthisis (HP:0000090)4.34679027
16Bronchitis (HP:0012387)4.18193959
17Mitochondrial inheritance (HP:0001427)4.11111558
18Increased CSF lactate (HP:0002490)4.06372320
19Abnormal spermatogenesis (HP:0008669)4.00430437
20Abnormality of the lower motor neuron (HP:0002366)3.96107399
21Progressive macrocephaly (HP:0004481)3.90131429
22Delayed CNS myelination (HP:0002188)3.81099200
23Azoospermia (HP:0000027)3.76358491
24Type I transferrin isoform profile (HP:0003642)3.63890639
25Increased hepatocellular lipid droplets (HP:0006565)3.47759306
26Cerebral edema (HP:0002181)3.46657440
27Abnormality of the renal medulla (HP:0100957)3.40372473
28Lipid accumulation in hepatocytes (HP:0006561)3.39619888
29Gonadotropin excess (HP:0000837)3.35669586
30Recurrent sinusitis (HP:0011108)3.33247486
31Renal Fanconi syndrome (HP:0001994)3.26351139
32Hepatocellular necrosis (HP:0001404)3.25873713
33Hepatic necrosis (HP:0002605)3.18112100
34Recurrent otitis media (HP:0000403)3.07321354
35Medial flaring of the eyebrow (HP:0010747)3.06908197
36Male infertility (HP:0003251)3.05127052
37Increased serum lactate (HP:0002151)3.00848266
38Amyotrophic lateral sclerosis (HP:0007354)2.95252750
39Abnormality of pyrimidine metabolism (HP:0004353)2.88840281
40Type II lissencephaly (HP:0007260)2.88683821
41Tubulointerstitial nephritis (HP:0001970)2.87824271
42Lactic acidosis (HP:0003128)2.86481295
43Cholecystitis (HP:0001082)2.84045961
44Abnormal gallbladder physiology (HP:0012438)2.84045961
45Fibular hypoplasia (HP:0003038)2.81750536
46Abnormality of midbrain morphology (HP:0002418)2.79174916
47Molar tooth sign on MRI (HP:0002419)2.79174916
48Abnormal protein N-linked glycosylation (HP:0012347)2.74453451
49Abnormal protein glycosylation (HP:0012346)2.74453451
50Abnormal glycosylation (HP:0012345)2.74453451
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.74453451
52Abnormality of cells of the erythroid lineage (HP:0012130)2.70357829
53Tubular atrophy (HP:0000092)2.69849889
54Abnormality of urine glucose concentration (HP:0011016)2.67393896
55Glycosuria (HP:0003076)2.67393896
56Cerebral hypomyelination (HP:0006808)2.67163159
57Abnormality of alanine metabolism (HP:0010916)2.66819404
58Hyperalaninemia (HP:0003348)2.66819404
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66819404
60Generalized aminoaciduria (HP:0002909)2.63081207
61Reticulocytopenia (HP:0001896)2.60270311
62Supernumerary spleens (HP:0009799)2.57638492
63Increased intramyocellular lipid droplets (HP:0012240)2.57060261
64Lethargy (HP:0001254)2.56674376
653-Methylglutaconic aciduria (HP:0003535)2.55275964
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53565224
67Abnormal number of erythroid precursors (HP:0012131)2.50756319
68CNS hypomyelination (HP:0003429)2.48367238
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.46707752
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.46707752
71Retinal dysplasia (HP:0007973)2.44525584
72Optic disc pallor (HP:0000543)2.43551560
73Increased serum pyruvate (HP:0003542)2.42730530
74Tubulointerstitial abnormality (HP:0001969)2.42399435
75Impulsivity (HP:0100710)2.40794119
76Leukodystrophy (HP:0002415)2.39194666
77Respiratory difficulties (HP:0002880)2.38566874
78Respiratory failure (HP:0002878)2.36152274
79Abnormality of glycolysis (HP:0004366)2.34845975
80Exercise intolerance (HP:0003546)2.34835728
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29910750
82Aplasia/hypoplasia of the uterus (HP:0008684)2.28986869
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28861199
8411 pairs of ribs (HP:0000878)2.26067410
85Prolonged partial thromboplastin time (HP:0003645)2.24463624
86Postaxial foot polydactyly (HP:0001830)2.23277148
87Upper motor neuron abnormality (HP:0002127)2.22507495
88Sparse eyelashes (HP:0000653)2.21482296
89CNS demyelination (HP:0007305)2.19249444
90Increased muscle lipid content (HP:0009058)2.16702451
91X-linked dominant inheritance (HP:0001423)2.16098810
92Recurrent bronchitis (HP:0002837)2.14883814
93Abnormality of the anterior horn cell (HP:0006802)2.12111287
94Degeneration of anterior horn cells (HP:0002398)2.12111287
95Congenital primary aphakia (HP:0007707)2.08973114
96Absent thumb (HP:0009777)2.08847913
97Gait imbalance (HP:0002141)2.07501961
98Abnormality of the ileum (HP:0001549)2.07324390
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06958036
100Hypobetalipoproteinemia (HP:0003563)2.05729099
101Impaired proprioception (HP:0010831)2.05113703
102Microglossia (HP:0000171)2.03904585
103Delayed myelination (HP:0012448)2.03200134
104Facial cleft (HP:0002006)2.02406730
105Meckel diverticulum (HP:0002245)2.01893956
106Hyperphosphaturia (HP:0003109)2.01176367
107Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00696311
108Large for gestational age (HP:0001520)2.00406234
109Aplasia/Hypoplasia of the uvula (HP:0010293)2.00085135
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3545353
111Dynein arm defect of respiratory motile cilia (HP:0012255)12.1144147
112Absent/shortened dynein arms (HP:0200106)12.1144147
113Congenital hepatic fibrosis (HP:0002612)1.97346623
114Hypoplastic pelvis (HP:0008839)1.97069501
115Poor speech (HP:0002465)1.96760254
116Abnormality of serum amino acid levels (HP:0003112)1.95425659
117Renal dysplasia (HP:0000110)1.95407634
118Stage 5 chronic kidney disease (HP:0003774)1.93822232
119Abnormality of renal resorption (HP:0011038)1.93248553
120Stenosis of the external auditory canal (HP:0000402)1.91773809
121Abnormality of the renal cortex (HP:0011035)1.90362337
122Tubulointerstitial fibrosis (HP:0005576)1.90204372
123Testicular atrophy (HP:0000029)1.88839975
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88136879
125Pancreatic fibrosis (HP:0100732)1.87185405
126Methylmalonic aciduria (HP:0012120)1.86794919
127Hyperglycinemia (HP:0002154)1.86404285
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86070021
129Aplasia/Hypoplasia of the fibula (HP:0006492)1.85276523
130Median cleft lip (HP:0000161)1.85242196
131Hypokinesia (HP:0002375)1.85116034
132Exertional dyspnea (HP:0002875)1.85095763
133Abnormality of the preputium (HP:0100587)1.82291535
134Selective tooth agenesis (HP:0001592)1.82211502
135Short ribs (HP:0000773)1.82185337
136Oculomotor apraxia (HP:0000657)1.81877079
137Abnormality of methionine metabolism (HP:0010901)1.81836377
138Metabolic acidosis (HP:0001942)1.79243799
139Concave nail (HP:0001598)1.79195479
140Nephrogenic diabetes insipidus (HP:0009806)1.77477136
141Postaxial hand polydactyly (HP:0001162)1.77111193
142Fibular aplasia (HP:0002990)1.76577543
143Renal tubular dysfunction (HP:0000124)1.75249469
144Abnormal drinking behavior (HP:0030082)1.75242523
145Polydipsia (HP:0001959)1.75242523
146Chronic sinusitis (HP:0011109)1.74485180
147Muscular hypotonia of the trunk (HP:0008936)1.74266035
148Abnormality of the dental root (HP:0006486)1.73607135
149Taurodontia (HP:0000679)1.73607135
150Abnormality of permanent molar morphology (HP:0011071)1.73607135
151Blindness (HP:0000618)1.73227641
152Congenital, generalized hypertrichosis (HP:0004540)1.73003625
153Carpal bone hypoplasia (HP:0001498)1.72945287
154Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72604498
155Poor coordination (HP:0002370)1.72384907
156Nausea (HP:0002018)1.71291945
157Absent frontal sinuses (HP:0002688)1.71112369
158J-shaped sella turcica (HP:0002680)1.70558714
159Microvesicular hepatic steatosis (HP:0001414)1.69810706
160Macrocytic anemia (HP:0001972)1.69070465
161Breast carcinoma (HP:0003002)1.66893167
162Abnormality of molar morphology (HP:0011070)1.63020892
163Abnormality of molar (HP:0011077)1.63020892
164Abnormality of the dental pulp (HP:0006479)1.58860067
165Aplasia/Hypoplasia of the tongue (HP:0010295)1.57190165
166Bile duct proliferation (HP:0001408)1.56002948
167Abnormal biliary tract physiology (HP:0012439)1.56002948
168Abnormality of ocular smooth pursuit (HP:0000617)1.55205347
169Cystic liver disease (HP:0006706)1.54706713
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53432110
171Genital tract atresia (HP:0001827)1.53387162
172Abnormality of dentin (HP:0010299)1.53275677
173Abnormality of renal excretion (HP:0011036)1.50283542
174Vaginal atresia (HP:0000148)1.48608835
175Tongue fasciculations (HP:0001308)1.47759627
176Heterotopia (HP:0002282)1.46763797
177Absent epiphyses (HP:0010577)1.42588175
178Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.42588175
179Spastic tetraparesis (HP:0001285)1.41076869
180Aplasia/Hypoplasia of the lens (HP:0008063)1.41033386
181Short thorax (HP:0010306)1.40238801
182Pancreatic cysts (HP:0001737)1.38647853
183Atrophy/Degeneration involving motor neurons (HP:0007373)1.33804033
184Nephroblastoma (Wilms tumor) (HP:0002667)1.33531273
185Muscle fibrillation (HP:0010546)1.31127791
186Papillary thyroid carcinoma (HP:0002895)1.30466953
187Large eyes (HP:0001090)1.30230550
188Deformed sella turcica (HP:0002681)1.27662964
189Sloping forehead (HP:0000340)1.26163419
190True hermaphroditism (HP:0010459)1.25355282
191Conjunctival telangiectasia (HP:0000524)1.25165755
192Missing ribs (HP:0000921)1.22915717
193Spontaneous abortion (HP:0005268)1.22079886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.34378926
2PDK49.34378926
3PDK26.10111755
4TESK13.45899873
5EIF2AK33.29946265
6VRK23.25856024
7MST42.79483395
8ICK2.57063848
9TRIM282.50824170
10PRKD32.49070886
11ZAK2.40449065
12EPHA22.21362606
13NME22.19080787
14PNCK2.13191606
15PTK2B2.11705734
16WNK42.08634044
17NEK22.03834415
18STK392.02059309
19FRK1.79355559
20CDC71.71703835
21MAP4K21.61246483
22CASK1.52630529
23TLK11.46329331
24MAP3K121.44671453
25WEE11.42339957
26NME11.30947031
27NUAK11.21487867
28GRK71.18731972
29VRK11.17023166
30CDK121.14268584
31PLK41.13263109
32ARAF1.11097321
33EPHA41.10558157
34OXSR11.10193908
35LIMK11.04263206
36STK381.03988783
37CCNB11.03732630
38CDK81.02101753
39BCKDK1.01908751
40ERBB40.97611951
41TTK0.96465499
42ACVR1B0.92229018
43TYRO30.91411064
44BCR0.91190578
45STK30.91077597
46WNK10.89766357
47MST1R0.88073927
48DYRK30.87217159
49TSSK60.86430974
50CSNK1G30.85579113
51ATR0.81728400
52MAPK150.81057054
53MAPKAPK30.80796626
54CHEK20.80187748
55PINK10.80102667
56CHEK10.79270082
57IRAK10.78774567
58ADRBK20.78591795
59CSNK1G10.76500888
60PDK10.76085654
61PASK0.75887297
62PRKCI0.74362387
63STK38L0.73408583
64LMTK20.72928411
65BRSK20.72365685
66PLK10.71419246
67PKN10.71288428
68BMPR1B0.70743171
69CDK90.70487637
70GRK10.69932832
71MINK10.68996954
72ERBB30.65877386
73STK100.65520042
74DYRK1B0.65245483
75RPS6KA50.64932482
76DYRK20.64772626
77CSNK1A10.64182294
78INSRR0.59939889
79PRKCE0.58977912
80MKNK20.56616291
81CSNK1G20.54274021
82ATM0.53997804
83CSNK1A1L0.52808875
84EIF2AK20.52729459
85BUB10.51040713
86AKT20.50121146
87ILK0.45331296
88ADRBK10.42281533
89TESK20.41220587
90CAMK2G0.39947450
91CLK10.37812984
92PHKG20.36951418
93PHKG10.36951418
94BRSK10.36427398
95RPS6KA40.35530572
96CAMK2A0.33941516
97MKNK10.33896645
98PRKACA0.33085705
99SRPK10.30679545
100IRAK20.28870801
101MTOR0.27525833
102NTRK20.26206387
103PAK10.25956682
104WNK30.25235253
105CDK70.24894107
106MAP2K60.23331416
107CDK20.23078036
108CDK10.21504773
109RPS6KB10.21196243
110BRAF0.21021605
111PRKCG0.19641641
112CSNK2A10.19416419
113EIF2AK10.19177323
114MAP3K40.18943194
115AKT30.18730382
116PRKAA10.18036862
117PBK0.17876208
118PDPK10.16428709
119NEK10.16081152
120CSNK2A20.15737441
121MARK30.15394081
122CAMK1G0.15392843
123AURKB0.15358252
124AURKA0.14371241
125PRKDC0.12937705
126NEK60.11837963
127MAP2K70.11718216
128YES10.11208390
129CSNK1D0.10523152
130GSK3B0.10421354
131STK160.09236940
132MAPK80.08833371
133CDK40.08185328
134CDK30.06425890
135PRKACB0.05607290
136MAPK100.05171752
137MUSK0.04211536
138PRKACG0.04088445
139PDGFRB0.03124747
140CDC42BPA0.03060251
141EGFR0.02839566
142CSNK1E0.02492596
143PLK30.02470591
144MELK0.01926072
145CAMKK10.01690097
146PRKG10.01563737
147RPS6KA10.01155111
148STK40.00042503
149PRKCB-0.0244554
150PLK2-0.0229345
151PIM1-0.0226734
152CDK15-0.0198158
153PAK4-0.0190995
154MARK2-0.0160585
155MAPK1-0.0137516
156MAPK14-0.0094210
157RPS6KA3-0.0040761

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.09993482
2Basal transcription factors_Homo sapiens_hsa030224.16575635
3Pyruvate metabolism_Homo sapiens_hsa006203.80565725
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.37456462
5Fanconi anemia pathway_Homo sapiens_hsa034603.33473518
6Ribosome_Homo sapiens_hsa030103.32857267
7Propanoate metabolism_Homo sapiens_hsa006403.09583334
8Pentose phosphate pathway_Homo sapiens_hsa000303.07459561
9* Oxidative phosphorylation_Homo sapiens_hsa001903.03241933
10Selenocompound metabolism_Homo sapiens_hsa004502.98481797
11Fatty acid biosynthesis_Homo sapiens_hsa000612.82506866
12Parkinsons disease_Homo sapiens_hsa050122.55170449
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41187785
14Oocyte meiosis_Homo sapiens_hsa041142.38403968
15RNA transport_Homo sapiens_hsa030132.36656468
16Glucagon signaling pathway_Homo sapiens_hsa049222.35457893
17Dorso-ventral axis formation_Homo sapiens_hsa043202.32919677
18Protein export_Homo sapiens_hsa030602.25275311
19Primary bile acid biosynthesis_Homo sapiens_hsa001202.09367875
20Homologous recombination_Homo sapiens_hsa034402.06571161
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02388251
22mRNA surveillance pathway_Homo sapiens_hsa030151.97753934
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96344982
24Linoleic acid metabolism_Homo sapiens_hsa005911.95771172
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95347235
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92315118
27Huntingtons disease_Homo sapiens_hsa050161.79870504
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.78179713
29Glycerolipid metabolism_Homo sapiens_hsa005611.77154844
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.76816893
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.76539396
32Folate biosynthesis_Homo sapiens_hsa007901.76160529
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.75277192
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.68108702
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62864994
36Sulfur relay system_Homo sapiens_hsa041221.60139751
37Proteasome_Homo sapiens_hsa030501.56093692
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54948489
39Alzheimers disease_Homo sapiens_hsa050101.47126036
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45632008
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41837776
42Sulfur metabolism_Homo sapiens_hsa009201.41575032
43Retinol metabolism_Homo sapiens_hsa008301.40220131
44Purine metabolism_Homo sapiens_hsa002301.39092449
45Fatty acid elongation_Homo sapiens_hsa000621.37740997
46Carbon metabolism_Homo sapiens_hsa012001.36017086
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35655264
48* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33505833
49DNA replication_Homo sapiens_hsa030301.26745982
50Cell cycle_Homo sapiens_hsa041101.24272188
51Fructose and mannose metabolism_Homo sapiens_hsa000511.22738889
52Peroxisome_Homo sapiens_hsa041461.20341277
53Biosynthesis of amino acids_Homo sapiens_hsa012301.18388399
54Tryptophan metabolism_Homo sapiens_hsa003801.18093787
55Glycerophospholipid metabolism_Homo sapiens_hsa005641.11733106
56One carbon pool by folate_Homo sapiens_hsa006701.10202672
57PPAR signaling pathway_Homo sapiens_hsa033201.10089930
58Amphetamine addiction_Homo sapiens_hsa050311.10019970
59Regulation of autophagy_Homo sapiens_hsa041401.09964086
60Spliceosome_Homo sapiens_hsa030401.09227167
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07472500
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07355186
63Mismatch repair_Homo sapiens_hsa034301.07069010
64Phenylalanine metabolism_Homo sapiens_hsa003601.06371322
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.04075427
66beta-Alanine metabolism_Homo sapiens_hsa004100.96858981
67RNA degradation_Homo sapiens_hsa030180.95625782
68Pyrimidine metabolism_Homo sapiens_hsa002400.95125392
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91576644
70Ether lipid metabolism_Homo sapiens_hsa005650.89701582
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89291462
72Base excision repair_Homo sapiens_hsa034100.89124598
73Antigen processing and presentation_Homo sapiens_hsa046120.89085436
74Nucleotide excision repair_Homo sapiens_hsa034200.88276451
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88256781
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87169584
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87043217
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86313412
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85547667
80Starch and sucrose metabolism_Homo sapiens_hsa005000.83017286
81Renin secretion_Homo sapiens_hsa049240.82051258
82Butanoate metabolism_Homo sapiens_hsa006500.80389484
83Arginine biosynthesis_Homo sapiens_hsa002200.80229112
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77695637
85Glutathione metabolism_Homo sapiens_hsa004800.75180476
86Fat digestion and absorption_Homo sapiens_hsa049750.74340183
87Fatty acid metabolism_Homo sapiens_hsa012120.69397121
88Mineral absorption_Homo sapiens_hsa049780.69094454
89Tyrosine metabolism_Homo sapiens_hsa003500.68962979
90Steroid biosynthesis_Homo sapiens_hsa001000.68850644
91Renin-angiotensin system_Homo sapiens_hsa046140.64212811
92Arginine and proline metabolism_Homo sapiens_hsa003300.63301738
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61929120
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61539476
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60567584
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60512655
97Caffeine metabolism_Homo sapiens_hsa002320.60075569
98Long-term potentiation_Homo sapiens_hsa047200.59920414
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58974276
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58141641
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57617608
102Complement and coagulation cascades_Homo sapiens_hsa046100.55641943
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55451845
104Non-homologous end-joining_Homo sapiens_hsa034500.55247074
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54363488
106N-Glycan biosynthesis_Homo sapiens_hsa005100.54073345
107Systemic lupus erythematosus_Homo sapiens_hsa053220.53666537
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51448883
109Phototransduction_Homo sapiens_hsa047440.51402435
110Histidine metabolism_Homo sapiens_hsa003400.51066939
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49409069
112Epstein-Barr virus infection_Homo sapiens_hsa051690.48196872
113Nitrogen metabolism_Homo sapiens_hsa009100.46831183
114Fatty acid degradation_Homo sapiens_hsa000710.44596943
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.42966874
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42533442
117* Metabolic pathways_Homo sapiens_hsa011000.42248502
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42027302
119Calcium signaling pathway_Homo sapiens_hsa040200.41322297
120p53 signaling pathway_Homo sapiens_hsa041150.40161138
121Arachidonic acid metabolism_Homo sapiens_hsa005900.39073062
122Chemical carcinogenesis_Homo sapiens_hsa052040.38493274
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37466870
124ABC transporters_Homo sapiens_hsa020100.36306813
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35686784
126Viral carcinogenesis_Homo sapiens_hsa052030.34003429
127Collecting duct acid secretion_Homo sapiens_hsa049660.33929321
128Vibrio cholerae infection_Homo sapiens_hsa051100.32939036
129Inositol phosphate metabolism_Homo sapiens_hsa005620.32626074
130Estrogen signaling pathway_Homo sapiens_hsa049150.32279001
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32093407
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30860180
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30762364
134Bile secretion_Homo sapiens_hsa049760.30565875
135Galactose metabolism_Homo sapiens_hsa000520.29275945
136Legionellosis_Homo sapiens_hsa051340.27413442
137VEGF signaling pathway_Homo sapiens_hsa043700.26503190
138Hedgehog signaling pathway_Homo sapiens_hsa043400.26160577
139AMPK signaling pathway_Homo sapiens_hsa041520.25365244
140Herpes simplex infection_Homo sapiens_hsa051680.23809657
141* Cardiac muscle contraction_Homo sapiens_hsa042600.20724376
142HTLV-I infection_Homo sapiens_hsa051660.20364728
143RNA polymerase_Homo sapiens_hsa030200.19047221
144Endocytosis_Homo sapiens_hsa041440.18656431
145Wnt signaling pathway_Homo sapiens_hsa043100.17340864
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13621938
147Taste transduction_Homo sapiens_hsa047420.13585217
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10315667
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.08172443
150Influenza A_Homo sapiens_hsa051640.07545727
151Alcoholism_Homo sapiens_hsa050340.07448686
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.03342265
153Synaptic vesicle cycle_Homo sapiens_hsa047210.00868786
154Pancreatic secretion_Homo sapiens_hsa04972-0.0028517
155Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0021895

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