ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	potassium ion export (GO:0071435)	7.14887492
2	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	7.10184808
3	substrate-independent telencephalic tangential migration (GO:0021826)	7.10184808
4	piRNA metabolic process (GO:0034587)	6.78794756
5	dopaminergic neuron differentiation (GO:0071542)	6.49161122
6	membrane repolarization (GO:0086009)	5.78694981
7	DNA methylation involved in gamete generation (GO:0043046)	5.72614495
8	regulation of dopamine metabolic process (GO:0042053)	5.39756221
9	regulation of catecholamine metabolic process (GO:0042069)	5.39756221
10	ribosomal small subunit assembly (GO:0000028)	5.39608521
11	mating behavior (GO:0007617)	5.05916624
12	behavioral response to nicotine (GO:0035095)	4.84944737
13	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.76201070
14	protein insertion into membrane (GO:0051205)	4.54679046
15	ATP synthesis coupled proton transport (GO:0015986)	4.49749582
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.49749582
17	membrane repolarization during action potential (GO:0086011)	4.48490461
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.44587419
19	response to insecticide (GO:0017085)	4.40309179
20	maternal behavior (GO:0042711)	4.30399202
21	neuron maturation (GO:0042551)	4.29832735
22	axonal fasciculation (GO:0007413)	4.26106667
23	axon ensheathment in central nervous system (GO:0032291)	4.12690926
24	central nervous system myelination (GO:0022010)	4.12690926
25	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.05092266
26	mitochondrion transport along microtubule (GO:0047497)	4.05092266
27	dentate gyrus development (GO:0021542)	4.03187325
28	neuron recognition (GO:0008038)	3.98967669
29	protein localization to cilium (GO:0061512)	3.97735499
30	presynaptic membrane organization (GO:0097090)	3.91643537
31	dopamine biosynthetic process (GO:0042416)	3.86587839
32	regulation of meiosis I (GO:0060631)	3.76499480
33	ganglion development (GO:0061548)	3.72432242
34	establishment of mitochondrion localization (GO:0051654)	3.68306664
35	parental behavior (GO:0060746)	3.65649586
36	synapsis (GO:0007129)	3.61846790
37	peristalsis (GO:0030432)	3.54493924
38	catecholamine biosynthetic process (GO:0042423)	3.40011476
39	catechol-containing compound biosynthetic process (GO:0009713)	3.40011476
40	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.33896712
41	adult walking behavior (GO:0007628)	3.33068566
42	DNA alkylation (GO:0006305)	3.32083614
43	DNA methylation (GO:0006306)	3.32083614
44	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.31052260
45	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.31052260
46	meiotic cell cycle (GO:0051321)	3.30763632
47	fucose catabolic process (GO:0019317)	3.30618363
48	L-fucose metabolic process (GO:0042354)	3.30618363
49	L-fucose catabolic process (GO:0042355)	3.30618363
50	protein neddylation (GO:0045116)	3.27282907
51	axon extension (GO:0048675)	3.24963904
52	pyrimidine nucleobase catabolic process (GO:0006208)	3.22240671
53	chaperone-mediated protein transport (GO:0072321)	3.21103664
54	regulation of synapse structural plasticity (GO:0051823)	3.17059168
55	regulation of microtubule-based movement (GO:0060632)	3.15427059
56	protein polyglutamylation (GO:0018095)	3.14998058
57	tongue development (GO:0043586)	3.06040519
58	striatum development (GO:0021756)	3.04734666
59	prepulse inhibition (GO:0060134)	3.04265320
60	positive regulation of growth hormone secretion (GO:0060124)	3.02973076
61	central nervous system projection neuron axonogenesis (GO:0021952)	3.02588373
62	neuron migration (GO:0001764)	3.01944346
63	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.00746976
64	synapse assembly (GO:0007416)	3.00698851
65	response to amphetamine (GO:0001975)	2.99814933
66	retinal rod cell development (GO:0046548)	2.99495201
67	fear response (GO:0042596)	2.99375167
68	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.96433689
69	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.94203900
70	neuronal ion channel clustering (GO:0045161)	2.89795586
71	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.88869944
72	resolution of meiotic recombination intermediates (GO:0000712)	2.87526099
73	behavioral fear response (GO:0001662)	2.87349764
74	behavioral defense response (GO:0002209)	2.87349764
75	body morphogenesis (GO:0010171)	2.87076946
76	nucleobase catabolic process (GO:0046113)	2.86910129
77	genetic imprinting (GO:0071514)	2.85920222
78	behavioral response to cocaine (GO:0048148)	2.85433823
79	dopamine transport (GO:0015872)	2.85248543
80	regulation of acrosome reaction (GO:0060046)	2.83601738
81	phosphorelay signal transduction system (GO:0000160)	2.80531491
82	transmission of nerve impulse (GO:0019226)	2.80382638
83	regulation of respiratory gaseous exchange (GO:0043576)	2.77498289
84	positive regulation of RNA splicing (GO:0033120)	2.76514382
85	regulation of neurotransmitter uptake (GO:0051580)	2.75843573
86	dopamine metabolic process (GO:0042417)	2.74677616
87	inner mitochondrial membrane organization (GO:0007007)	2.74660647
88	GTP biosynthetic process (GO:0006183)	2.73255362
89	sequestering of actin monomers (GO:0042989)	2.73113312
90	regulation of growth hormone secretion (GO:0060123)	2.71210194
91	neuron projection extension (GO:1990138)	2.70899798
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.68551295
93	termination of RNA polymerase III transcription (GO:0006386)	2.68551295
94	neuron cell-cell adhesion (GO:0007158)	2.65263696
95	positive regulation of meiosis (GO:0045836)	2.63731935
96	synaptic transmission, dopaminergic (GO:0001963)	2.63410083
97	DNA methylation or demethylation (GO:0044728)	2.61907466
98	gene silencing by RNA (GO:0031047)	2.61487607
99	maturation of SSU-rRNA (GO:0030490)	2.61166523
100	cerebellar Purkinje cell layer development (GO:0021680)	2.58861672

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	8.05987213
2	EZH2_22144423_ChIP-Seq_EOC_Human	6.01086516
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.45008973
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.27781935
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.97468464
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.91526496
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84728600
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.74600218
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.62621859
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.55740079
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.42712246
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.37976602
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.29214960
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24308896
15	VDR_22108803_ChIP-Seq_LS180_Human	2.23594117
16	REST_21632747_ChIP-Seq_MESCs_Mouse	2.16148135
17	RNF2_27304074_Chip-Seq_NSC_Mouse	1.98277002
18	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.96082323
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.90580849
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.88390326
21	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.87036502
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86628514
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.71270259
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.68518914
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.67028857
26	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.66544902
27	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.62468808
28	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.59070508
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.58918764
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56663236
31	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.54121627
32	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.54121627
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.53653678
34	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52864381
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46550683
36	EWS_26573619_Chip-Seq_HEK293_Human	1.40202628
37	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.38390668
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31923332
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.25960037
40	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.21921698
41	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.20759990
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17660819
43	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.17515085
44	P300_19829295_ChIP-Seq_ESCs_Human	1.17080962
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16497873
46	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16112900
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15818308
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12442225
49	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10790110
50	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.10228280
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08035388
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06826763
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06826763
54	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.05975531
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.05515852
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05321155
57	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.04091973
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.04082665
59	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.03796809
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03571615
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03297450
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03088740
63	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.01237499
64	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.01071883
65	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.00791198
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00724214
67	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.00234740
68	MYC_19829295_ChIP-Seq_ESCs_Human	0.97849366
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97408097
70	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.96491544
71	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.95770726
72	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.94861721
73	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.94680047
74	GBX2_23144817_ChIP-Seq_PC3_Human	0.94491111
75	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.94344506
76	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.94294768
77	TBL1_22424771_ChIP-Seq_293T_Human	0.93312107
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.91840970
79	ETV1_20927104_ChIP-Seq_GIST48_Human	0.91398621
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89973382
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.89342026
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.87368897
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.87368897
84	NCOR_22424771_ChIP-Seq_293T_Human	0.86442412
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.86164393
86	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.85949832
87	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.84216116
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.82222878
89	CTCF_27219007_Chip-Seq_Bcells_Human	0.81771818
90	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.78971748
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.78889742
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.78889742
93	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.78790057
94	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.78764463
95	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.78686146
96	STAT3_23295773_ChIP-Seq_U87_Human	0.77418478
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.76768123
98	AR_25329375_ChIP-Seq_VCAP_Human	0.76349120
99	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.76099199
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.75815313

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008004_abnormal_stomach_pH	5.84654266
2	MP0008877_abnormal_DNA_methylation	5.23750674
3	MP0000566_synostosis	4.64561896
4	MP0003787_abnormal_imprinting	3.84261189
5	MP0005423_abnormal_somatic_nervous	3.70836005
6	MP0003123_paternal_imprinting	3.58757843
7	MP0006292_abnormal_olfactory_placode	3.44151299
8	MP0009379_abnormal_foot_pigmentation	3.37150660
9	MP0003121_genomic_imprinting	3.10394207
10	MP0003122_maternal_imprinting	2.83188238
11	MP0004145_abnormal_muscle_electrophysio	2.42760753
12	MP0003693_abnormal_embryo_hatching	2.33889339
13	MP0004742_abnormal_vestibular_system	2.24430112
14	MP0002938_white_spotting	2.18895619
15	MP0009745_abnormal_behavioral_response	2.10882211
16	MP0002184_abnormal_innervation	2.08667085
17	MP0003718_maternal_effect	2.04137854
18	MP0003879_abnormal_hair_cell	1.90663872
19	MP0004859_abnormal_synaptic_plasticity	1.89144777
20	MP0003880_abnormal_central_pattern	1.86260206
21	MP0002822_catalepsy	1.86221842
22	MP0008995_early_reproductive_senescence	1.75170582
23	MP0001529_abnormal_vocalization	1.70749028
24	MP0000778_abnormal_nervous_system	1.67896107
25	MP0001440_abnormal_grooming_behavior	1.67626049
26	MP0003635_abnormal_synaptic_transmissio	1.61498743
27	MP0006276_abnormal_autonomic_nervous	1.55765848
28	MP0000569_abnormal_digit_pigmentation	1.47814417
29	MP0003315_abnormal_perineum_morphology	1.42919509
30	MP0002572_abnormal_emotion/affect_behav	1.38387931
31	MP0001905_abnormal_dopamine_level	1.38184709
32	MP0003938_abnormal_ear_development	1.34916819
33	MP0002272_abnormal_nervous_system	1.34516552
34	MP0002557_abnormal_social/conspecific_i	1.33546614
35	MP0002163_abnormal_gland_morphology	1.31995853
36	MP0002063_abnormal_learning/memory/cond	1.31155112
37	MP0003646_muscle_fatigue	1.30905259
38	MP0005174_abnormal_tail_pigmentation	1.27545712
39	MP0000427_abnormal_hair_cycle	1.25114264
40	MP0001486_abnormal_startle_reflex	1.24249344
41	MP0000955_abnormal_spinal_cord	1.22746869
42	MP0009046_muscle_twitch	1.22707187
43	MP0005551_abnormal_eye_electrophysiolog	1.19481282
44	MP0000647_abnormal_sebaceous_gland	1.18699493
45	MP0002067_abnormal_sensory_capabilities	1.17685499
46	MP0002752_abnormal_somatic_nervous	1.15122939
47	MP0004142_abnormal_muscle_tone	1.14511037
48	MP0002210_abnormal_sex_determination	1.14334076
49	MP0003119_abnormal_digestive_system	1.09086980
50	MP0002064_seizures	1.07823219
51	MP0001970_abnormal_pain_threshold	1.06964648
52	MP0004885_abnormal_endolymph	1.06807271
53	MP0008789_abnormal_olfactory_epithelium	1.04712186
54	MP0002102_abnormal_ear_morphology	1.04294371
55	MP0002734_abnormal_mechanical_nocicepti	1.02276760
56	MP0002882_abnormal_neuron_morphology	1.01513513
57	MP0000026_abnormal_inner_ear	1.00427658
58	MP0004811_abnormal_neuron_physiology	0.96767635
59	MP0005499_abnormal_olfactory_system	0.96045368
60	MP0005394_taste/olfaction_phenotype	0.96045368
61	MP0002733_abnormal_thermal_nociception	0.95451975
62	MP0001348_abnormal_lacrimal_gland	0.94054431
63	MP0003698_abnormal_male_reproductive	0.93084018
64	MP0001929_abnormal_gametogenesis	0.92703892
65	MP0001986_abnormal_taste_sensitivity	0.91910200
66	MP0010030_abnormal_orbit_morphology	0.91418774
67	MP0002233_abnormal_nose_morphology	0.89841564
68	MP0005187_abnormal_penis_morphology	0.89094048
69	MP0000653_abnormal_sex_gland	0.88831827
70	MP0002095_abnormal_skin_pigmentation	0.86659336
71	MP0001963_abnormal_hearing_physiology	0.83675714
72	MP0003329_amyloid_beta_deposits	0.83475350
73	MP0003937_abnormal_limbs/digits/tail_de	0.82653525
74	MP0001145_abnormal_male_reproductive	0.81952450
75	MP0000631_abnormal_neuroendocrine_gland	0.81603582
76	MP0005646_abnormal_pituitary_gland	0.81400593
77	MP0002876_abnormal_thyroid_physiology	0.80173225
78	MP0003861_abnormal_nervous_system	0.80008327
79	MP0002152_abnormal_brain_morphology	0.79659374
80	MP0000383_abnormal_hair_follicle	0.78563055
81	MP0002638_abnormal_pupillary_reflex	0.77073150
82	MP0003011_delayed_dark_adaptation	0.76134498
83	MP0002909_abnormal_adrenal_gland	0.74330380
84	MP0002229_neurodegeneration	0.73133056
85	MP0003186_abnormal_redox_activity	0.73124528
86	MP0002161_abnormal_fertility/fecundity	0.72227763
87	MP0004270_analgesia	0.71868680
88	MP0003283_abnormal_digestive_organ	0.71631901
89	MP0005195_abnormal_posterior_eye	0.69589684
90	MP0002066_abnormal_motor_capabilities/c	0.67538548
91	MP0005389_reproductive_system_phenotype	0.66837254
92	MP0005379_endocrine/exocrine_gland_phen	0.64980360
93	MP0002160_abnormal_reproductive_system	0.64908199
94	MP0010386_abnormal_urinary_bladder	0.63806188
95	MP0003942_abnormal_urinary_system	0.62967212
96	MP0008007_abnormal_cellular_replicative	0.60054532
97	MP0003699_abnormal_female_reproductive	0.59722614
98	MP0000428_abnormal_craniofacial_morphol	0.59179549
99	MP0001119_abnormal_female_reproductive	0.57815165
100	MP0004924_abnormal_behavior	0.57583346

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Polyphagia (HP:0002591)	4.76058750
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.41001586
3	Limb dystonia (HP:0002451)	4.08589513
4	Myokymia (HP:0002411)	3.89058327
5	Reticulocytopenia (HP:0001896)	3.45616459
6	Progressive cerebellar ataxia (HP:0002073)	3.36803045
7	Neonatal hypoglycemia (HP:0001998)	3.25090538
8	11 pairs of ribs (HP:0000878)	3.16148393
9	Chorioretinal atrophy (HP:0000533)	3.07850999
10	Abnormality of the labia minora (HP:0012880)	2.93885961
11	Amblyopia (HP:0000646)	2.85745146
12	Neoplasm of the adrenal cortex (HP:0100641)	2.82012427
13	Pachygyria (HP:0001302)	2.81834738
14	Acute necrotizing encephalopathy (HP:0006965)	2.74229844
15	Amyotrophic lateral sclerosis (HP:0007354)	2.73329780
16	Enlarged penis (HP:0000040)	2.70105131
17	Horizontal nystagmus (HP:0000666)	2.66652463
18	Ventricular fibrillation (HP:0001663)	2.66272220
19	Postural tremor (HP:0002174)	2.66060396
20	Abolished electroretinogram (ERG) (HP:0000550)	2.60424726
21	Abnormal eating behavior (HP:0100738)	2.58174037
22	Mutism (HP:0002300)	2.56498311
23	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.53794482
24	Growth hormone deficiency (HP:0000824)	2.52934595
25	Down-sloping shoulders (HP:0200021)	2.52462878
26	Agitation (HP:0000713)	2.48237106
27	Hyperthyroidism (HP:0000836)	2.47780915
28	Adrenal hypoplasia (HP:0000835)	2.47378152
29	Hypoplasia of the brainstem (HP:0002365)	2.44935928
30	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.44935928
31	Hyperventilation (HP:0002883)	2.44117075
32	Abnormal hair whorl (HP:0010721)	2.43172862
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.41708419
34	Acute encephalopathy (HP:0006846)	2.40874928
35	Anterior segment dysgenesis (HP:0007700)	2.39517693
36	Pendular nystagmus (HP:0012043)	2.38166742
37	Colon cancer (HP:0003003)	2.33371211
38	Esotropia (HP:0000565)	2.31195536
39	Abnormality of binocular vision (HP:0011514)	2.28938230
40	Diplopia (HP:0000651)	2.28938230
41	Akinesia (HP:0002304)	2.28512514
42	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.27204178
43	Macroorchidism (HP:0000053)	2.26546993
44	Oligodactyly (hands) (HP:0001180)	2.26356359
45	3-Methylglutaconic aciduria (HP:0003535)	2.25914202
46	Decreased muscle mass (HP:0003199)	2.24353940
47	Septo-optic dysplasia (HP:0100842)	2.24302591
48	Missing ribs (HP:0000921)	2.23963748
49	Progressive macrocephaly (HP:0004481)	2.22520867
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18540956
51	Abnormality of alanine metabolism (HP:0010916)	2.18540956
52	Hyperalaninemia (HP:0003348)	2.18540956
53	Neurofibrillary tangles (HP:0002185)	2.16994825
54	Optic disc pallor (HP:0000543)	2.13783767
55	Truncal obesity (HP:0001956)	2.11662542
56	Increased IgM level (HP:0003496)	2.10362152
57	Lissencephaly (HP:0001339)	2.09820206
58	Prolonged QT interval (HP:0001657)	2.09482876
59	Hyperphosphatemia (HP:0002905)	2.06156109
60	Partial agenesis of the corpus callosum (HP:0001338)	2.04406246
61	Osteomalacia (HP:0002749)	2.04299191
62	Abnormality of cells of the erythroid lineage (HP:0012130)	2.04198715
63	Sleep apnea (HP:0010535)	2.03747267
64	Median cleft lip (HP:0000161)	2.02582253
65	Severe Myopia (HP:0011003)	2.01494637
66	Gait imbalance (HP:0002141)	2.01130438
67	Chronic bronchitis (HP:0004469)	1.99104079
68	Mitochondrial inheritance (HP:0001427)	1.96795393
69	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96285129
70	Macrocytic anemia (HP:0001972)	1.95975987
71	Limb hypertonia (HP:0002509)	1.94917388
72	Hepatoblastoma (HP:0002884)	1.94248502
73	Poor speech (HP:0002465)	1.91244015
74	Enlarged kidneys (HP:0000105)	1.89970590
75	Concave nail (HP:0001598)	1.84969570
76	Type II lissencephaly (HP:0007260)	1.83127673
77	Short 4th metacarpal (HP:0010044)	1.82430433
78	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.82430433
79	Syncope (HP:0001279)	1.82392978
80	Sclerocornea (HP:0000647)	1.81732407
81	Abnormality of the nasal septum (HP:0000419)	1.80725132
82	Metaphyseal dysplasia (HP:0100255)	1.79424794
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.79164960
84	Short chin (HP:0000331)	1.78633856
85	Optic nerve hypoplasia (HP:0000609)	1.78618678
86	Small hand (HP:0200055)	1.78143163
87	Disinhibition (HP:0000734)	1.74186029
88	Inappropriate behavior (HP:0000719)	1.72929741
89	Abnormality of the line of Schwalbe (HP:0008048)	1.72795608
90	Posterior embryotoxon (HP:0000627)	1.72746454
91	Volvulus (HP:0002580)	1.72665269
92	Hypocalcemia (HP:0002901)	1.72099037
93	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.71020848
94	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.71020848
95	Poor suck (HP:0002033)	1.70685174
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.70160462
97	Abnormality of the renal cortex (HP:0011035)	1.68747234
98	Gaze-evoked nystagmus (HP:0000640)	1.68394317
99	Congenital stationary night blindness (HP:0007642)	1.68192694
100	Lipid accumulation in hepatocytes (HP:0006561)	1.67872373

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	5.51916992
2	WNK3	5.19597727
3	CASK	4.51698191
4	NTRK3	3.91834621
5	PHKG1	3.06785533
6	PHKG2	3.06785533
7	TRIB3	2.73293340
8	SIK2	2.48296047
9	DYRK2	2.43857597
10	MAPK13	2.35949457
11	STK16	2.15145109
12	PNCK	2.06763443
13	CDC7	2.02186616
14	EPHB2	1.81519521
15	ZAK	1.75978757
16	MAP3K4	1.69846620
17	PINK1	1.67995857
18	RPS6KA4	1.62235020
19	CAMK1G	1.56119431
20	MAP4K2	1.42926550
21	MAP2K7	1.42266420
22	STK24	1.40364087
23	CDK19	1.37905371
24	BMPR1B	1.32103691
25	EPHA4	1.30021330
26	DYRK1A	1.29902219
27	PRKCI	1.27615570
28	KSR1	1.25518084
29	CHEK2	1.20381090
30	ADRBK2	1.17595679
31	WNK4	1.17287162
32	CAMK1D	1.09511068
33	TAOK3	1.08838375
34	TTK	1.06997295
35	PKN1	1.03600954
36	MAPK15	1.02152658
37	ABL2	0.96595927
38	EIF2AK2	0.94615437
39	MAP3K10	0.92534638
40	NME1	0.84621427
41	NTRK2	0.83687919
42	MINK1	0.83142869
43	ILK	0.81108230
44	MAPK12	0.80686745
45	TXK	0.78369810
46	MARK2	0.73831969
47	FRK	0.70872246
48	TSSK6	0.70149057
49	MAP3K9	0.67418976
50	TAF1	0.64168487
51	MKNK2	0.63590723
52	NEK2	0.63564926
53	MAP2K4	0.62748155
54	AURKA	0.62449033
55	DAPK2	0.62331321
56	SRPK1	0.62111963
57	MAP4K1	0.62059088
58	PRKCZ	0.59709133
59	ATR	0.59296533
60	TLK1	0.57735422
61	CLK1	0.55475679
62	MAP3K6	0.54543128
63	MAP3K2	0.54518685
64	PLK1	0.54060764
65	DYRK3	0.53976545
66	PLK3	0.51925778
67	FES	0.51343331
68	PRKCG	0.50760888
69	NUAK1	0.49131225
70	MET	0.48658497
71	CDK5	0.47325296
72	CSNK1G2	0.47319518
73	BUB1	0.44912537
74	CAMK1	0.44219072
75	CSNK1E	0.43467512
76	PRKAA1	0.42920276
77	GRK1	0.40290151
78	OXSR1	0.36429623
79	RET	0.36357100
80	PRKACA	0.35705319
81	ATM	0.33792775
82	SGK1	0.31769832
83	CSNK1D	0.31737835
84	ADRBK1	0.30103187
85	CDK14	0.29957865
86	CDK3	0.28823241
87	SYK	0.28723153
88	TIE1	0.28412470
89	BCR	0.27876251
90	PRKG1	0.27699595
91	GSK3A	0.27511007
92	PRKDC	0.25672284
93	CDK11A	0.25609725
94	GSK3B	0.25559420
95	BRSK1	0.25469223
96	VRK1	0.25220677
97	CDK15	0.25136786
98	CAMK2A	0.24954001
99	CDK2	0.24516169
100	PRKACG	0.23804843

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.50321588
2	Nicotine addiction_Homo sapiens_hsa05033	3.48535820
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.36822304
4	Parkinsons disease_Homo sapiens_hsa05012	3.30710927
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.92840845
6	Ribosome_Homo sapiens_hsa03010	2.62134598
7	Alzheimers disease_Homo sapiens_hsa05010	2.37472464
8	RNA polymerase_Homo sapiens_hsa03020	2.35934082
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.31722147
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.24634731
11	RNA degradation_Homo sapiens_hsa03018	2.20512787
12	Phototransduction_Homo sapiens_hsa04744	2.20138749
13	Huntingtons disease_Homo sapiens_hsa05016	2.17842002
14	Morphine addiction_Homo sapiens_hsa05032	2.04974523
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.02121213
16	GABAergic synapse_Homo sapiens_hsa04727	1.85515004
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.78812322
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.76366554
19	Cell cycle_Homo sapiens_hsa04110	1.75261606
20	Basal transcription factors_Homo sapiens_hsa03022	1.72057884
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70972403
22	Homologous recombination_Homo sapiens_hsa03440	1.56543590
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.55076863
24	Insulin secretion_Homo sapiens_hsa04911	1.53319715
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38328025
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34905253
27	Base excision repair_Homo sapiens_hsa03410	1.33500272
28	Cocaine addiction_Homo sapiens_hsa05030	1.33167296
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29501551
30	Olfactory transduction_Homo sapiens_hsa04740	1.28562309
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26274868
32	Taste transduction_Homo sapiens_hsa04742	1.24477846
33	Glutamatergic synapse_Homo sapiens_hsa04724	1.21664704
34	Protein export_Homo sapiens_hsa03060	1.16004227
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.15923322
36	Sulfur relay system_Homo sapiens_hsa04122	1.12266193
37	RNA transport_Homo sapiens_hsa03013	1.09352623
38	Gap junction_Homo sapiens_hsa04540	1.06563626
39	Mismatch repair_Homo sapiens_hsa03430	1.05516119
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05033279
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03588745
42	Spliceosome_Homo sapiens_hsa03040	1.00184071
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99451177
44	Oocyte meiosis_Homo sapiens_hsa04114	0.97991857
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96602229
46	p53 signaling pathway_Homo sapiens_hsa04115	0.95381586
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93320204
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.91276609
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.88856029
50	Serotonergic synapse_Homo sapiens_hsa04726	0.88508574
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88423220
52	MAPK signaling pathway_Homo sapiens_hsa04010	0.87648799
53	Dopaminergic synapse_Homo sapiens_hsa04728	0.80916012
54	Amphetamine addiction_Homo sapiens_hsa05031	0.80157025
55	Steroid biosynthesis_Homo sapiens_hsa00100	0.79306584
56	Propanoate metabolism_Homo sapiens_hsa00640	0.78926274
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.76025811
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.75683781
59	Axon guidance_Homo sapiens_hsa04360	0.74843924
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73230152
61	Purine metabolism_Homo sapiens_hsa00230	0.69602310
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.66393332
63	Folate biosynthesis_Homo sapiens_hsa00790	0.65768209
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65566117
65	Butanoate metabolism_Homo sapiens_hsa00650	0.65537762
66	DNA replication_Homo sapiens_hsa03030	0.64443422
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62607818
68	Circadian entrainment_Homo sapiens_hsa04713	0.60750207
69	Caffeine metabolism_Homo sapiens_hsa00232	0.60065453
70	Cholinergic synapse_Homo sapiens_hsa04725	0.59388070
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.57789119
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.57550485
73	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.56169076
74	Alcoholism_Homo sapiens_hsa05034	0.55575832
75	Gastric acid secretion_Homo sapiens_hsa04971	0.55494407
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.50350918
77	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46947265
78	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46740334
79	Metabolic pathways_Homo sapiens_hsa01100	0.46167342
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.45017535
81	Regulation of autophagy_Homo sapiens_hsa04140	0.44433197
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.39063407
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35397919
84	Type II diabetes mellitus_Homo sapiens_hsa04930	0.33333373
85	Renin secretion_Homo sapiens_hsa04924	0.32647310
86	Retinol metabolism_Homo sapiens_hsa00830	0.32522292
87	Glucagon signaling pathway_Homo sapiens_hsa04922	0.31244546
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31174040
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.29156097
90	Long-term depression_Homo sapiens_hsa04730	0.28878613
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.26669719
92	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.25953472
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.25882787
94	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.25641287
95	Proteasome_Homo sapiens_hsa03050	0.25348263
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.24541896
97	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.23889295
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.22182148
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21818374
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20672585

COX7BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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