ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	8.30700136
2	neurofilament cytoskeleton organization (GO:0060052)	6.45585971
3	neurotransmitter catabolic process (GO:0042135)	6.28635354
4	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	6.27038461
5	nerve growth factor signaling pathway (GO:0038180)	6.16826308
6	positive regulation of amino acid transport (GO:0051957)	6.02953106
7	gonadal mesoderm development (GO:0007506)	5.53688033
8	positive regulation of synaptic transmission, GABAergic (GO:0032230)	5.40294463
9	ionotropic glutamate receptor signaling pathway (GO:0035235)	5.18029888
10	pyrimidine nucleobase catabolic process (GO:0006208)	5.08779053
11	secondary heart field specification (GO:0003139)	4.68890345
12	heart field specification (GO:0003128)	4.68890345
13	histone H2A acetylation (GO:0043968)	4.66975715
14	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.44912822
15	neurotransmitter-gated ion channel clustering (GO:0072578)	4.39779240
16	neuron projection extension involved in neuron projection guidance (GO:1902284)	4.28621488
17	axon extension involved in axon guidance (GO:0048846)	4.28621488
18	rRNA methylation (GO:0031167)	4.13312204
19	Rap protein signal transduction (GO:0032486)	4.07219329
20	negative regulation of neurotransmitter secretion (GO:0046929)	4.00277043
21	anterograde axon cargo transport (GO:0008089)	3.99724678
22	regulation of timing of cell differentiation (GO:0048505)	3.95661614
23	nucleobase catabolic process (GO:0046113)	3.94705237
24	behavioral response to pain (GO:0048266)	3.86025299
25	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.82527798
26	regulation of mitochondrial translation (GO:0070129)	3.79563647
27	negative regulation of neurotransmitter transport (GO:0051589)	3.75687997
28	axon regeneration (GO:0031103)	3.75579401
29	glutamate receptor signaling pathway (GO:0007215)	3.74960735
30	neural tube formation (GO:0001841)	3.74509507
31	rRNA modification (GO:0000154)	3.70495957
32	negative chemotaxis (GO:0050919)	3.67232619
33	synaptic transmission, glutamatergic (GO:0035249)	3.66441926
34	cellular response to nerve growth factor stimulus (GO:1990090)	3.62761503
35	response to nerve growth factor (GO:1990089)	3.62761503
36	negative regulation of dendrite development (GO:2000171)	3.59085862
37	regulation of amino acid transport (GO:0051955)	3.54121334
38	L-fucose catabolic process (GO:0042355)	3.41462005
39	fucose catabolic process (GO:0019317)	3.41462005
40	L-fucose metabolic process (GO:0042354)	3.41462005
41	regulation of establishment of cell polarity (GO:2000114)	3.30104356
42	regulation of development, heterochronic (GO:0040034)	3.29468392
43	positive regulation of vasculogenesis (GO:2001214)	3.28658182
44	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.26668628
45	ubiquinone biosynthetic process (GO:0006744)	3.26266843
46	protein complex biogenesis (GO:0070271)	3.25299317
47	ubiquinone metabolic process (GO:0006743)	3.24544908
48	intermediate filament organization (GO:0045109)	3.23864614
49	positive regulation of male gonad development (GO:2000020)	3.23370909
50	specification of organ identity (GO:0010092)	3.21167412
51	somite development (GO:0061053)	3.17974848
52	retinal ganglion cell axon guidance (GO:0031290)	3.17765870
53	negative regulation of axon guidance (GO:1902668)	3.16033303
54	negative regulation of dendrite morphogenesis (GO:0050774)	3.06322728
55	axon development (GO:0061564)	3.00545413
56	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.93086357
57	negative regulation of synaptic transmission (GO:0050805)	2.92755836
58	negative regulation of axon extension (GO:0030517)	2.92620615
59	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.89730875
60	synaptic transmission, cholinergic (GO:0007271)	2.88213950
61	neurotransmitter metabolic process (GO:0042133)	2.86256946
62	regulation of sarcomere organization (GO:0060297)	2.84125687
63	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.83852898
64	mitochondrial respiratory chain complex assembly (GO:0033108)	2.82503296
65	protein polyglutamylation (GO:0018095)	2.81319318
66	aldehyde catabolic process (GO:0046185)	2.79261320
67	neuronal action potential (GO:0019228)	2.76373583
68	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.74552845
69	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.74552845
70	regulation of energy homeostasis (GO:2000505)	2.74465664
71	positive regulation of fatty acid oxidation (GO:0046321)	2.72475870
72	DNA double-strand break processing (GO:0000729)	2.72102598
73	inner mitochondrial membrane organization (GO:0007007)	2.72021194
74	ganglion development (GO:0061548)	2.69724522
75	neuron-neuron synaptic transmission (GO:0007270)	2.69655389
76	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.65281466
77	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65039889
78	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65039889
79	NADH dehydrogenase complex assembly (GO:0010257)	2.65039889
80	DNA damage response, detection of DNA damage (GO:0042769)	2.63715699
81	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.63615686
82	positive regulation of organic acid transport (GO:0032892)	2.62398980
83	membrane hyperpolarization (GO:0060081)	2.61435373
84	microtubule bundle formation (GO:0001578)	2.60704631
85	quinone biosynthetic process (GO:1901663)	2.60359202
86	positive regulation of amine transport (GO:0051954)	2.59608673
87	respiratory electron transport chain (GO:0022904)	2.59195817
88	regulation of male gonad development (GO:2000018)	2.58178699
89	Notch signaling involved in heart development (GO:0061314)	2.57328304
90	regulation of germinal center formation (GO:0002634)	2.57121862
91	electron transport chain (GO:0022900)	2.52171350
92	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.52083380
93	microtubule depolymerization (GO:0007019)	2.51754304
94	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.50749547
95	ATP synthesis coupled proton transport (GO:0015986)	2.50749547
96	limb bud formation (GO:0060174)	2.50131494
97	cytochrome complex assembly (GO:0017004)	2.48656606
98	central nervous system projection neuron axonogenesis (GO:0021952)	2.47874097
99	neuron cell-cell adhesion (GO:0007158)	2.47829650
100	cerebral cortex radially oriented cell migration (GO:0021799)	2.47593078

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.69307682
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.56250400
3	TAF15_26573619_Chip-Seq_HEK293_Human	3.37301077
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.33022527
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23791607
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.08391032
7	FUS_26573619_Chip-Seq_HEK293_Human	2.69281912
8	VDR_22108803_ChIP-Seq_LS180_Human	2.63382716
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.55875873
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50977501
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.39321978
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.29361074
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26557862
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.22321249
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21780729
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09115348
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08969642
18	EWS_26573619_Chip-Seq_HEK293_Human	2.04369358
19	IRF1_19129219_ChIP-ChIP_H3396_Human	2.03313982
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.99377475
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99243481
22	P300_19829295_ChIP-Seq_ESCs_Human	1.90978151
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.90736206
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.87786802
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.85197602
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79668405
27	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.78751404
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.77111969
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76129002
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.74441622
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71701378
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.71499572
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71141023
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.67496293
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.66204988
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65193061
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.58310368
38	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.57336540
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.54963986
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54014261
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49898875
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49608331
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49058720
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.48190792
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48190792
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48063656
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45222895
48	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.45131384
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42376818
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.40410354
51	AR_25329375_ChIP-Seq_VCAP_Human	1.38245256
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37261725
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.36854126
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36384438
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35496938
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34406266
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33299951
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32933856
59	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32933856
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29878241
61	STAT3_23295773_ChIP-Seq_U87_Human	1.24243151
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.24239458
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.23964894
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23216597
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22298738
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.21251010
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20231072
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20042945
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19349664
70	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17664102
71	TCF4_23295773_ChIP-Seq_U87_Human	1.16070769
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.16028724
73	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15941387
74	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15596555
75	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.14959444
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14862744
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12831667
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11126744
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.08847284
80	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08786081
81	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08745094
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08641098
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05355304
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04041766
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04041766
86	ERG_20517297_ChIP-Seq_VCAP_Human	1.03998747
87	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03011787
88	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.02662693
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01299082
90	SOX9_26525672_Chip-Seq_HEART_Mouse	1.00960796
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00818428
92	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00371675
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99592468
94	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97829066
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97818464
96	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.97054660
97	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.96699037
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95663129
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95040349
100	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.94877493

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002735_abnormal_chemical_nociception	4.55900429
2	MP0002638_abnormal_pupillary_reflex	3.08436992
3	MP0008877_abnormal_DNA_methylation	2.90523656
4	MP0003880_abnormal_central_pattern	2.66422877
5	MP0003787_abnormal_imprinting	2.63792100
6	MP0000569_abnormal_digit_pigmentation	2.62324749
7	MP0010386_abnormal_urinary_bladder	2.44194787
8	MP0003011_delayed_dark_adaptation	2.37215337
9	MP0003646_muscle_fatigue	2.21619947
10	MP0000778_abnormal_nervous_system	2.18217516
11	MP0003121_genomic_imprinting	2.09034870
12	MP0001968_abnormal_touch/_nociception	2.04372718
13	MP0001486_abnormal_startle_reflex	2.00881156
14	MP0003635_abnormal_synaptic_transmissio	1.94212727
15	MP0002736_abnormal_nociception_after	1.93319573
16	MP0009046_muscle_twitch	1.92680811
17	MP0000372_irregular_coat_pigmentation	1.87366687
18	MP0000537_abnormal_urethra_morphology	1.87361013
19	MP0003252_abnormal_bile_duct	1.87260942
20	MP0006292_abnormal_olfactory_placode	1.84664088
21	MP0006276_abnormal_autonomic_nervous	1.83824720
22	MP0001970_abnormal_pain_threshold	1.78746422
23	MP0005367_renal/urinary_system_phenotyp	1.77919434
24	MP0000516_abnormal_urinary_system	1.77919434
25	MP0009379_abnormal_foot_pigmentation	1.76334539
26	MP0002272_abnormal_nervous_system	1.69959357
27	MP0002837_dystrophic_cardiac_calcinosis	1.67354452
28	MP0005085_abnormal_gallbladder_physiolo	1.66264005
29	MP0009697_abnormal_copulation	1.61886796
30	MP0002653_abnormal_ependyma_morphology	1.61783652
31	MP0005360_urolithiasis	1.61448120
32	MP0004270_analgesia	1.59778402
33	MP0005551_abnormal_eye_electrophysiolog	1.56355985
34	MP0008995_early_reproductive_senescence	1.52116009
35	MP0001529_abnormal_vocalization	1.47135454
36	MP0003806_abnormal_nucleotide_metabolis	1.44919890
37	MP0009745_abnormal_behavioral_response	1.43980785
38	MP0003122_maternal_imprinting	1.39397255
39	MP0001501_abnormal_sleep_pattern	1.28291919
40	MP0002572_abnormal_emotion/affect_behav	1.27863983
41	MP0002184_abnormal_innervation	1.23965905
42	MP0002734_abnormal_mechanical_nocicepti	1.23471819
43	MP0004215_abnormal_myocardial_fiber	1.21303046
44	MP0005646_abnormal_pituitary_gland	1.20787814
45	MP0001188_hyperpigmentation	1.19661106
46	MP0004019_abnormal_vitamin_homeostasis	1.16648356
47	MP0004133_heterotaxia	1.16366770
48	MP0005084_abnormal_gallbladder_morpholo	1.14019614
49	MP0004742_abnormal_vestibular_system	1.13860391
50	MP0004142_abnormal_muscle_tone	1.13394114
51	MP0000955_abnormal_spinal_cord	1.13240093
52	MP0001986_abnormal_taste_sensitivity	1.11809652
53	MP0002095_abnormal_skin_pigmentation	1.10886652
54	MP0005253_abnormal_eye_physiology	1.10884104
55	MP0002751_abnormal_autonomic_nervous	1.09947768
56	MP0003633_abnormal_nervous_system	1.09824810
57	MP0000538_abnormal_urinary_bladder	1.08839604
58	MP0002733_abnormal_thermal_nociception	1.08319060
59	MP0002102_abnormal_ear_morphology	1.06249254
60	MP0002064_seizures	1.06171894
61	MP0008058_abnormal_DNA_repair	1.05090251
62	MP0002752_abnormal_somatic_nervous	1.03165129
63	MP0002063_abnormal_learning/memory/cond	1.01909910
64	MP0005075_abnormal_melanosome_morpholog	1.00775045
65	MP0004859_abnormal_synaptic_plasticity	0.97959470
66	MP0002557_abnormal_social/conspecific_i	0.96883898
67	MP0003119_abnormal_digestive_system	0.96554971
68	MP0005379_endocrine/exocrine_gland_phen	0.95308713
69	MP0001756_abnormal_urination	0.94220499
70	MP0008875_abnormal_xenobiotic_pharmacok	0.93954006
71	MP0003631_nervous_system_phenotype	0.92902968
72	MP0002282_abnormal_trachea_morphology	0.92806519
73	MP0003195_calcinosis	0.92149325
74	MP0001919_abnormal_reproductive_system	0.90570884
75	MP0002229_neurodegeneration	0.90222960
76	MP0002882_abnormal_neuron_morphology	0.89918631
77	MP0005174_abnormal_tail_pigmentation	0.88960872
78	MP0005410_abnormal_fertilization	0.88523542
79	MP0004883_abnormal_blood_vessel	0.88222367
80	MP0005167_abnormal_blood-brain_barrier	0.85632339
81	MP0005386_behavior/neurological_phenoty	0.85543753
82	MP0004924_abnormal_behavior	0.85543753
83	MP0003718_maternal_effect	0.85515722
84	MP0005187_abnormal_penis_morphology	0.84020079
85	MP0005248_abnormal_Harderian_gland	0.83937875
86	MP0001963_abnormal_hearing_physiology	0.83783472
87	MP0002067_abnormal_sensory_capabilities	0.79828344
88	MP0003698_abnormal_male_reproductive	0.79579726
89	MP0005389_reproductive_system_phenotype	0.78110908
90	MP0004084_abnormal_cardiac_muscle	0.77233854
91	MP0000015_abnormal_ear_pigmentation	0.76845948
92	MP0003632_abnormal_nervous_system	0.74727046
93	MP0006072_abnormal_retinal_apoptosis	0.74682448
94	MP0005645_abnormal_hypothalamus_physiol	0.74292991
95	MP0000647_abnormal_sebaceous_gland	0.73868530
96	MP0002234_abnormal_pharynx_morphology	0.73787050
97	MP0000230_abnormal_systemic_arterial	0.73648834
98	MP0005171_absent_coat_pigmentation	0.72982317
99	MP0005195_abnormal_posterior_eye	0.72697682
100	MP0000026_abnormal_inner_ear	0.71485759

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ulnar claw (HP:0001178)	6.01203703
2	Volvulus (HP:0002580)	3.61519018
3	Acute necrotizing encephalopathy (HP:0006965)	3.53612021
4	Medial flaring of the eyebrow (HP:0010747)	3.38769871
5	Focal motor seizures (HP:0011153)	3.38301991
6	Adactyly (HP:0009776)	3.32302137
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.28787711
8	Segmental peripheral demyelination/remyelination (HP:0003481)	3.26308482
9	Mitochondrial inheritance (HP:0001427)	3.09362266
10	Acute encephalopathy (HP:0006846)	3.02583615
11	Increased CSF lactate (HP:0002490)	2.98239472
12	Cerebellar dysplasia (HP:0007033)	2.98050953
13	Gait imbalance (HP:0002141)	2.97423816
14	Pancreatic fibrosis (HP:0100732)	2.95055917
15	Progressive macrocephaly (HP:0004481)	2.93645666
16	True hermaphroditism (HP:0010459)	2.84285565
17	Long clavicles (HP:0000890)	2.77089812
18	Congenital primary aphakia (HP:0007707)	2.76058577
19	Sclerocornea (HP:0000647)	2.74334309
20	Renal cortical cysts (HP:0000803)	2.69466129
21	Nephronophthisis (HP:0000090)	2.62119957
22	Focal seizures (HP:0007359)	2.61228304
23	Drooling (HP:0002307)	2.57002238
24	Pancreatic cysts (HP:0001737)	2.53422001
25	Abnormality of the renal medulla (HP:0100957)	2.48749359
26	Steppage gait (HP:0003376)	2.48599195
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.45361046
28	Atonic seizures (HP:0010819)	2.45256829
29	Short chin (HP:0000331)	2.45106272
30	Type 2 muscle fiber atrophy (HP:0003554)	2.41237137
31	Molar tooth sign on MRI (HP:0002419)	2.40910109
32	Abnormality of midbrain morphology (HP:0002418)	2.40910109
33	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.40603642
34	Nephrogenic diabetes insipidus (HP:0009806)	2.37349697
35	Abnormality of the musculature of the hand (HP:0001421)	2.35795757
36	Genital tract atresia (HP:0001827)	2.35398063
37	Hepatocellular necrosis (HP:0001404)	2.33706864
38	Vaginal atresia (HP:0000148)	2.33492274
39	Excessive salivation (HP:0003781)	2.32731558
40	Optic disc pallor (HP:0000543)	2.32364803
41	Congenital hepatic fibrosis (HP:0002612)	2.30261737
42	3-Methylglutaconic aciduria (HP:0003535)	2.29191126
43	Bile duct proliferation (HP:0001408)	2.28660871
44	Abnormal biliary tract physiology (HP:0012439)	2.28660871
45	Type II lissencephaly (HP:0007260)	2.28207601
46	Increased hepatocellular lipid droplets (HP:0006565)	2.28094190
47	Decreased muscle mass (HP:0003199)	2.22884133
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.20590020
49	Anencephaly (HP:0002323)	2.20333127
50	Broad-based gait (HP:0002136)	2.17912714
51	Hypothermia (HP:0002045)	2.16693736
52	Male pseudohermaphroditism (HP:0000037)	2.14771194
53	Abnormality of the renal cortex (HP:0011035)	2.13259371
54	Febrile seizures (HP:0002373)	2.12516520
55	Lipid accumulation in hepatocytes (HP:0006561)	2.12375143
56	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.12107367
57	Dialeptic seizures (HP:0011146)	2.12097949
58	Neonatal respiratory distress (HP:0002643)	2.08159610
59	Decreased central vision (HP:0007663)	2.07859593
60	Abnormality of chromosome stability (HP:0003220)	2.06615652
61	Myokymia (HP:0002411)	2.06406487
62	Dyskinesia (HP:0100660)	2.05788796
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.05617268
64	Abnormality of alanine metabolism (HP:0010916)	2.05617268
65	Hyperalaninemia (HP:0003348)	2.05617268
66	Abnormality of renal resorption (HP:0011038)	2.02934002
67	Cerebral edema (HP:0002181)	1.95805388
68	Absent speech (HP:0001344)	1.93967134
69	Leukodystrophy (HP:0002415)	1.92589338
70	Hypomagnesemia (HP:0002917)	1.92399206
71	Epidermoid cyst (HP:0200040)	1.91881714
72	Congenital stationary night blindness (HP:0007642)	1.91616627
73	Lissencephaly (HP:0001339)	1.91314821
74	Onion bulb formation (HP:0003383)	1.91165850
75	Hepatic necrosis (HP:0002605)	1.88223978
76	Muscle fiber atrophy (HP:0100295)	1.84929191
77	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.83888380
78	Small hand (HP:0200055)	1.82718574
79	Narrow forehead (HP:0000341)	1.82556286
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.81288352
81	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.80263533
82	Renal Fanconi syndrome (HP:0001994)	1.77088391
83	Sensory axonal neuropathy (HP:0003390)	1.75537077
84	Long nose (HP:0003189)	1.74464596
85	Lactic acidosis (HP:0003128)	1.74143447
86	Polydipsia (HP:0001959)	1.73808457
87	Abnormal drinking behavior (HP:0030082)	1.73808457
88	Inability to walk (HP:0002540)	1.72390139
89	Anterior segment dysgenesis (HP:0007700)	1.71859058
90	Short foot (HP:0001773)	1.71651419
91	Hepatoblastoma (HP:0002884)	1.71015211
92	Abnormality of the antihelix (HP:0009738)	1.70688038
93	Polyuria (HP:0000103)	1.70451605
94	Neoplasm of the heart (HP:0100544)	1.69295346
95	Chorioretinal atrophy (HP:0000533)	1.69290768
96	Respiratory failure (HP:0002878)	1.69124381
97	Increased serum lactate (HP:0002151)	1.67595475
98	Abnormal rod and cone electroretinograms (HP:0008323)	1.66504048
99	Epileptic encephalopathy (HP:0200134)	1.64336962
100	Retinal dysplasia (HP:0007973)	1.64314564

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.22427862
2	WNK3	3.69447443
3	CCNB1	3.51675044
4	MAPK13	3.26083152
5	BMPR1B	3.10859972
6	FRK	3.01848307
7	ACVR1B	2.77651202
8	EPHA4	2.52246647
9	CASK	2.52076766
10	PBK	2.34305901
11	MAP2K7	1.98371016
12	MAP3K4	1.86636044
13	CLK1	1.77770282
14	STK16	1.76766451
15	PINK1	1.74631820
16	PDK2	1.58028389
17	ZAK	1.54536812
18	DYRK2	1.53813997
19	MAP4K2	1.50987274
20	ADRBK2	1.45104654
21	MINK1	1.45097767
22	PRKD3	1.44091204
23	BRSK2	1.30520311
24	STK39	1.28128387
25	VRK1	1.26165121
26	CSNK1G1	1.25222626
27	PAK3	1.24468771
28	PRKCG	1.24395860
29	PLK3	1.21268759
30	CSNK1G3	1.20136181
31	STK38L	1.17890045
32	UHMK1	1.17294840
33	BCR	1.13609231
34	BUB1	1.11945913
35	SIK2	1.11217134
36	OXSR1	1.10531682
37	CSNK1G2	1.10099680
38	TGFBR1	0.96755117
39	ERBB2	0.94834689
40	NTRK2	0.88995051
41	PKN1	0.86731017
42	CDK19	0.83372845
43	ERBB3	0.82116696
44	CAMK2A	0.78922617
45	NEK2	0.77715600
46	NUAK1	0.76335460
47	CSNK1A1L	0.75765792
48	PLK4	0.75509047
49	PRKCE	0.74857632
50	GRK1	0.74326768
51	CDK3	0.73885404
52	OBSCN	0.72694253
53	PLK1	0.71026816
54	MAPK12	0.70229255
55	MKNK2	0.69542681
56	PLK2	0.67801841
57	PRKCH	0.66132479
58	MAPK4	0.61695006
59	PRKACA	0.61425729
60	MUSK	0.59076242
61	TIE1	0.58800077
62	PRKACG	0.58413081
63	TRIM28	0.57791638
64	MST4	0.56193435
65	SGK2	0.53422292
66	STK11	0.53320780
67	WEE1	0.52564360
68	TAOK3	0.51747148
69	MAP2K4	0.51115805
70	AKT3	0.51107151
71	PTK2B	0.51079448
72	BCKDK	0.50267296
73	ROCK1	0.50250845
74	WNK4	0.48644058
75	GSK3A	0.48601541
76	MAPK7	0.48443998
77	PRKCQ	0.48396319
78	ADRBK1	0.48225248
79	MAP2K1	0.48083060
80	MAP3K6	0.47681298
81	INSRR	0.46242318
82	PRKG1	0.45859580
83	CSNK1A1	0.45509158
84	RPS6KB1	0.44835139
85	CSNK1E	0.44348263
86	MARK3	0.44028536
87	CDK5	0.42619063
88	ATM	0.42150156
89	PIM2	0.41573954
90	SGK3	0.41439674
91	DYRK1A	0.39784574
92	PIK3CA	0.38641597
93	EIF2AK2	0.38062170
94	PRKCA	0.37188248
95	TXK	0.36097133
96	SGK223	0.36092563
97	SGK494	0.36092563
98	IKBKB	0.36077858
99	CSNK1D	0.36011456
100	PRKCB	0.35176184

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.33329496
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.12115358
3	Parkinsons disease_Homo sapiens_hsa05012	2.90879800
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.78749829
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.65288541
6	Alzheimers disease_Homo sapiens_hsa05010	2.25970970
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25426731
8	Taste transduction_Homo sapiens_hsa04742	2.25144367
9	Nicotine addiction_Homo sapiens_hsa05033	2.22955155
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.22136947
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.19754870
12	Protein export_Homo sapiens_hsa03060	2.17736662
13	Glutamatergic synapse_Homo sapiens_hsa04724	2.03783753
14	Phototransduction_Homo sapiens_hsa04744	2.00283908
15	Huntingtons disease_Homo sapiens_hsa05016	1.86376336
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85858481
17	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.80386084
18	RNA polymerase_Homo sapiens_hsa03020	1.77739631
19	Circadian entrainment_Homo sapiens_hsa04713	1.69537974
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67625767
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59335124
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58605718
23	Propanoate metabolism_Homo sapiens_hsa00640	1.57832029
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.55463342
25	Homologous recombination_Homo sapiens_hsa03440	1.53839312
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49253054
27	Proteasome_Homo sapiens_hsa03050	1.49220067
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48132281
29	GABAergic synapse_Homo sapiens_hsa04727	1.44770584
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.33305191
31	Butanoate metabolism_Homo sapiens_hsa00650	1.29882307
32	Morphine addiction_Homo sapiens_hsa05032	1.26331152
33	Ribosome_Homo sapiens_hsa03010	1.23813628
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23116797
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20857645
36	Olfactory transduction_Homo sapiens_hsa04740	1.16942945
37	Dopaminergic synapse_Homo sapiens_hsa04728	1.11784223
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09611030
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.09339948
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.09000622
41	Serotonergic synapse_Homo sapiens_hsa04726	1.08557873
42	Basal transcription factors_Homo sapiens_hsa03022	1.06315032
43	Circadian rhythm_Homo sapiens_hsa04710	1.05284909
44	Insulin secretion_Homo sapiens_hsa04911	1.05089226
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01848674
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.97485605
47	Axon guidance_Homo sapiens_hsa04360	0.96107214
48	Salivary secretion_Homo sapiens_hsa04970	0.91820759
49	RNA degradation_Homo sapiens_hsa03018	0.90486082
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89484915
51	Cocaine addiction_Homo sapiens_hsa05030	0.88684268
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86976717
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86924759
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78215654
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73986392
56	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.72269001
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70070342
58	Cholinergic synapse_Homo sapiens_hsa04725	0.69795852
59	Oocyte meiosis_Homo sapiens_hsa04114	0.69632723
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68032056
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67747891
62	Peroxisome_Homo sapiens_hsa04146	0.67206890
63	Gap junction_Homo sapiens_hsa04540	0.67118707
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61830880
65	Pancreatic secretion_Homo sapiens_hsa04972	0.61571417
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60261454
67	Long-term depression_Homo sapiens_hsa04730	0.60059029
68	Amphetamine addiction_Homo sapiens_hsa05031	0.59799668
69	Renin secretion_Homo sapiens_hsa04924	0.59720797
70	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.57710134
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57477765
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.56937750
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.56279175
74	Caffeine metabolism_Homo sapiens_hsa00232	0.55673159
75	Retinol metabolism_Homo sapiens_hsa00830	0.54868848
76	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52988089
77	Gastric acid secretion_Homo sapiens_hsa04971	0.52015950
78	Metabolic pathways_Homo sapiens_hsa01100	0.51436285
79	Spliceosome_Homo sapiens_hsa03040	0.51280213
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51111614
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.50759499
82	Purine metabolism_Homo sapiens_hsa00230	0.50684382
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50487661
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49486674
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48526283
86	Fatty acid elongation_Homo sapiens_hsa00062	0.46064383
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.45092199
88	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.44876417
89	Bile secretion_Homo sapiens_hsa04976	0.43942121
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.43539991
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.42670744
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.42567983
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41760317
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41229377
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39979202
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38524083
97	p53 signaling pathway_Homo sapiens_hsa04115	0.32318426
98	RNA transport_Homo sapiens_hsa03013	0.31350859
99	Tryptophan metabolism_Homo sapiens_hsa00380	0.30868513
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.30594511

COX7BP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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