COX7C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* respiratory electron transport chain (GO:0022904)9.21991157
2* electron transport chain (GO:0022900)8.97783618
3establishment of protein localization to mitochondrial membrane (GO:0090151)6.12646466
4ATP biosynthetic process (GO:0006754)6.02518472
5purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.51213487
6chaperone-mediated protein transport (GO:0072321)5.50632101
7purine nucleoside triphosphate biosynthetic process (GO:0009145)5.42128071
8oxidative phosphorylation (GO:0006119)5.40929560
9* hydrogen ion transmembrane transport (GO:1902600)5.21263638
10inner mitochondrial membrane organization (GO:0007007)5.18225681
11ribosomal small subunit biogenesis (GO:0042274)5.17987098
12viral transcription (GO:0019083)4.97911406
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.97402537
14NADH dehydrogenase complex assembly (GO:0010257)4.97402537
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.97402537
16protein neddylation (GO:0045116)4.94292057
17protein complex biogenesis (GO:0070271)4.89906064
18ribonucleoside triphosphate biosynthetic process (GO:0009201)4.83046184
19translational termination (GO:0006415)4.77266613
20* proton transport (GO:0015992)4.57138936
21mitochondrial respiratory chain complex assembly (GO:0033108)4.53503752
22* hydrogen transport (GO:0006818)4.49412417
23nuclear-transcribed mRNA catabolic process (GO:0000956)4.36576844
24cotranslational protein targeting to membrane (GO:0006613)4.24323182
25protein targeting to ER (GO:0045047)4.17730215
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.13051538
27mRNA catabolic process (GO:0006402)4.12531071
28nucleoside triphosphate biosynthetic process (GO:0009142)4.10263732
29establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03781100
30protein localization to endoplasmic reticulum (GO:0070972)3.99863369
31translational elongation (GO:0006414)3.90601428
32axon ensheathment in central nervous system (GO:0032291)3.89182332
33central nervous system myelination (GO:0022010)3.89182332
34mitochondrial transport (GO:0006839)3.88570687
35cellular protein complex disassembly (GO:0043624)3.81314264
36RNA catabolic process (GO:0006401)3.75415598
37viral life cycle (GO:0019058)3.74073964
38cellular component biogenesis (GO:0044085)3.72641103
39aerobic respiration (GO:0009060)3.72380241
40GTP biosynthetic process (GO:0006183)3.71646040
41tricarboxylic acid cycle (GO:0006099)3.68249817
42establishment of protein localization to mitochondrion (GO:0072655)3.55850229
43regulation of mitochondrial translation (GO:0070129)3.54012657
44protein targeting to mitochondrion (GO:0006626)3.53137456
45ribonucleoprotein complex biogenesis (GO:0022613)3.48918670
46purine nucleoside monophosphate biosynthetic process (GO:0009127)3.46810441
47purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.46810441
48protein localization to mitochondrion (GO:0070585)3.42566238
49fatty acid elongation (GO:0030497)3.42550722
50establishment of protein localization to membrane (GO:0090150)3.41270580
51sequestering of actin monomers (GO:0042989)3.36883002
52substantia nigra development (GO:0021762)3.34309029
53protein targeting (GO:0006605)3.32602393
54chromatin remodeling at centromere (GO:0031055)3.28655948
55* generation of precursor metabolites and energy (GO:0006091)3.28407057
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24847599
57quinone biosynthetic process (GO:1901663)3.22561232
58ubiquinone biosynthetic process (GO:0006744)3.22561232
59ribosomal small subunit assembly (GO:0000028)3.22392607
60intracellular protein transmembrane import (GO:0044743)3.22150133
61translation (GO:0006412)3.21714990
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19021522
63spliceosomal complex assembly (GO:0000245)3.16795568
64translational initiation (GO:0006413)3.14779420
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12908449
66proteasome assembly (GO:0043248)3.11059051
67UTP biosynthetic process (GO:0006228)3.09954423
68establishment of protein localization to organelle (GO:0072594)3.09682533
69CENP-A containing nucleosome assembly (GO:0034080)3.08783355
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08690338
71regulation of oxidative phosphorylation (GO:0002082)3.07273172
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06499475
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06499475
74ubiquinone metabolic process (GO:0006743)3.06474505
75ribosomal large subunit biogenesis (GO:0042273)3.05780246
76purine ribonucleoside biosynthetic process (GO:0046129)3.05671357
77purine nucleoside biosynthetic process (GO:0042451)3.05671357
78cellular respiration (GO:0045333)3.02018502
79protein complex disassembly (GO:0043241)3.00917916
80regulation of cellular respiration (GO:0043457)2.98044627
81ATP hydrolysis coupled proton transport (GO:0015991)2.95368252
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.95368252
83spliceosomal snRNP assembly (GO:0000387)2.94695630
84aldehyde catabolic process (GO:0046185)2.92797456
85regulation of acyl-CoA biosynthetic process (GO:0050812)2.91177472
86protein-cofactor linkage (GO:0018065)2.89067332
87rRNA processing (GO:0006364)2.87896206
88respiratory chain complex IV assembly (GO:0008535)2.87418364
89behavioral response to nicotine (GO:0035095)2.86348425
90protein targeting to membrane (GO:0006612)2.84684364
91macromolecular complex disassembly (GO:0032984)2.84564770
92UTP metabolic process (GO:0046051)2.84401484
93mitochondrion morphogenesis (GO:0070584)2.84399835
94sarcomere organization (GO:0045214)2.81015779
95DNA damage response, detection of DNA damage (GO:0042769)2.78635097
96rRNA metabolic process (GO:0016072)2.77350342
97protein localization to membrane (GO:0072657)2.76740603
98regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75265987
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74196202
100ribonucleoside monophosphate biosynthetic process (GO:0009156)2.73885145
101maturation of SSU-rRNA (GO:0030490)2.73749558
102cytochrome complex assembly (GO:0017004)2.70130510
103water-soluble vitamin biosynthetic process (GO:0042364)2.69441161
104long-chain fatty acid biosynthetic process (GO:0042759)2.67978038
105pyrimidine nucleotide catabolic process (GO:0006244)2.67805661
106regulation of cofactor metabolic process (GO:0051193)2.66418587
107regulation of coenzyme metabolic process (GO:0051196)2.66418587
108cellular ketone body metabolic process (GO:0046950)2.65588688
109cholesterol biosynthetic process (GO:0006695)2.64942154
110negative regulation of protein localization to cell surface (GO:2000009)2.64217762
111transcription elongation from RNA polymerase III promoter (GO:0006385)2.63624790
112termination of RNA polymerase III transcription (GO:0006386)2.63624790
113negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62617731
114positive regulation of action potential (GO:0045760)2.62145748
115dopamine transport (GO:0015872)2.58762943
116ribonucleoside biosynthetic process (GO:0042455)2.56212337
117muscle filament sliding (GO:0030049)2.55695688
118actin-myosin filament sliding (GO:0033275)2.55695688
119protein transmembrane transport (GO:0071806)2.52972958
120pseudouridine synthesis (GO:0001522)2.52777372
121regulation of cell communication by electrical coupling (GO:0010649)2.51964238
122nucleoside monophosphate biosynthetic process (GO:0009124)2.51549013
123establishment of integrated proviral latency (GO:0075713)2.51520360
124succinate metabolic process (GO:0006105)2.51098228
125NADH metabolic process (GO:0006734)2.49711813
126negative regulation of ligase activity (GO:0051352)2.47911301
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.47911301
128organelle disassembly (GO:1903008)2.40478608
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.39884231
130histone exchange (GO:0043486)2.39855050
131mitochondrial ATP synthesis coupled proton transport (GO:0042776)11.5785190
132ATP synthesis coupled proton transport (GO:0015986)10.9453497
133energy coupled proton transport, down electrochemical gradient (GO:0015985)10.9453497
134mitochondrial electron transport, NADH to ubiquinone (GO:0006120)10.1059679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.37886728
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.33272947
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97272129
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.23502764
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.22373239
6* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.11850612
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.10960027
8* EST1_17652178_ChIP-ChIP_JURKAT_Human2.97319307
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90541350
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83639473
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65694289
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61489241
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58666995
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.51402787
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50446721
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50068432
17VDR_22108803_ChIP-Seq_LS180_Human2.45363874
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40927603
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14300383
20* MYC_18555785_ChIP-Seq_MESCs_Mouse2.05904180
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90979336
22TAF15_26573619_Chip-Seq_HEK293_Human1.86162530
23FOXP3_21729870_ChIP-Seq_TREG_Human1.81156337
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.80401691
25EZH2_22144423_ChIP-Seq_EOC_Human1.75901023
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.74863942
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67932601
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.67512614
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64748178
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60048227
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57336405
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55683006
33* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53559379
34DCP1A_22483619_ChIP-Seq_HELA_Human1.52141225
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47312187
36* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47257952
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41487264
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38770133
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.36477969
40GABP_19822575_ChIP-Seq_HepG2_Human1.35706835
41EWS_26573619_Chip-Seq_HEK293_Human1.35676519
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35443255
43IRF1_19129219_ChIP-ChIP_H3396_Human1.35377183
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34121858
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33565458
46ELK1_19687146_ChIP-ChIP_HELA_Human1.32721600
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31598005
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30574134
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30515920
50ZNF274_21170338_ChIP-Seq_K562_Hela1.30342675
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.28329485
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27361343
53NANOG_16153702_ChIP-ChIP_HESCs_Human1.26337971
54* FUS_26573619_Chip-Seq_HEK293_Human1.24609114
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24436300
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21186022
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20975995
58VDR_23849224_ChIP-Seq_CD4+_Human1.19990134
59XRN2_22483619_ChIP-Seq_HELA_Human1.19140402
60* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18234930
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17900354
62* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17648253
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16585566
64ER_23166858_ChIP-Seq_MCF-7_Human1.16344658
65* TTF2_22483619_ChIP-Seq_HELA_Human1.13822787
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12708352
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12487676
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12209199
69HTT_18923047_ChIP-ChIP_STHdh_Human1.11281542
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11046985
71* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10834935
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.09950012
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09304488
74MYC_18940864_ChIP-ChIP_HL60_Human1.08258905
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08218719
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08088269
77* CBX2_27304074_Chip-Seq_ESCs_Mouse1.06114201
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05762213
79RNF2_27304074_Chip-Seq_NSC_Mouse1.03957656
80GBX2_23144817_ChIP-Seq_PC3_Human1.03346748
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03128013
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02672743
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02395043
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01266878
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.01256933
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01155280
87* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00976860
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00380686
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.00074407
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97960691
91CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96530540
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.95644776
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94803157
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94489188
95* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94059735
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92307098
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91821140
98IGF1R_20145208_ChIP-Seq_DFB_Human0.90394584
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90271565
100JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89711222
101TP53_22573176_ChIP-Seq_HFKS_Human0.89472496
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89133575
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89044439
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88609585
105* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88018351
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86835078
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.85820005
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85804429
109NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85505200
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83817597
111* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83214743
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83017361
113NANOG_20526341_ChIP-Seq_ESCs_Human0.82612246
114E2F1_21310950_ChIP-Seq_MCF-7_Human0.82534674
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82396057
116SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81482002
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81140873
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80748259
119* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80230178
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.80151121
121STAT1_20625510_ChIP-Seq_HELA_Human0.79839823
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79713532
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.79613725
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79565852
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79369576
126NCOR_22424771_ChIP-Seq_293T_Human0.79344049
127EZH2_18974828_ChIP-Seq_MESCs_Mouse0.78733176
128RNF2_18974828_ChIP-Seq_MESCs_Mouse0.78733176
129REST_21632747_ChIP-Seq_MESCs_Mouse0.78620761
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78412553
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78123684
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78058180
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77282769
134FOXP1_21924763_ChIP-Seq_HESCs_Human0.73127729
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72214071
136* P300_19829295_ChIP-Seq_ESCs_Human0.72143321
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.71343782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.39800104
2MP0003646_muscle_fatigue3.62789244
3MP0001529_abnormal_vocalization3.60605214
4MP0006292_abnormal_olfactory_placode3.59676524
5MP0003880_abnormal_central_pattern3.24763670
6MP0009379_abnormal_foot_pigmentation3.20718373
7MP0006036_abnormal_mitochondrial_physio2.99434255
8MP0000751_myopathy2.97018194
9MP0004215_abnormal_myocardial_fiber2.72497047
10MP0004084_abnormal_cardiac_muscle2.53879938
11MP0004036_abnormal_muscle_relaxation2.51450136
12MP0006276_abnormal_autonomic_nervous2.38181429
13MP0006035_abnormal_mitochondrial_morpho2.32811993
14MP0003136_yellow_coat_color2.31570066
15MP0005330_cardiomyopathy2.30570990
16MP0003806_abnormal_nucleotide_metabolis2.27609957
17MP0000749_muscle_degeneration2.27558630
18MP0004142_abnormal_muscle_tone2.16784179
19MP0001905_abnormal_dopamine_level2.14877099
20MP0003137_abnormal_impulse_conducting2.06367738
21MP0010030_abnormal_orbit_morphology1.96049405
22MP0002938_white_spotting1.90562347
23MP0001440_abnormal_grooming_behavior1.80145858
24MP0003123_paternal_imprinting1.77727734
25MP0001293_anophthalmia1.77713884
26MP0008789_abnormal_olfactory_epithelium1.75332512
27MP0003787_abnormal_imprinting1.69199686
28MP0003195_calcinosis1.69167183
29MP0003950_abnormal_plasma_membrane1.69129082
30MP0002972_abnormal_cardiac_muscle1.68384414
31MP0002332_abnormal_exercise_endurance1.65608328
32MP0003122_maternal_imprinting1.65391926
33MP0002163_abnormal_gland_morphology1.64268050
34MP0004145_abnormal_muscle_electrophysio1.63659448
35MP0004043_abnormal_pH_regulation1.63364896
36MP0000750_abnormal_muscle_regeneration1.61725526
37MP0002653_abnormal_ependyma_morphology1.56724758
38MP0005451_abnormal_body_composition1.55139498
39MP0000566_synostosis1.54430759
40MP0000920_abnormal_myelination1.53931400
41MP0003121_genomic_imprinting1.52460466
42MP0008877_abnormal_DNA_methylation1.51321739
43MP0000049_abnormal_middle_ear1.50308039
44MP0002272_abnormal_nervous_system1.48440288
45MP0005620_abnormal_muscle_contractility1.48051819
46MP0008775_abnormal_heart_ventricle1.47930809
47MP0005499_abnormal_olfactory_system1.47429570
48MP0005394_taste/olfaction_phenotype1.47429570
49MP0003693_abnormal_embryo_hatching1.47286251
50MP0000631_abnormal_neuroendocrine_gland1.47062672
51MP0001188_hyperpigmentation1.46084090
52MP0004484_altered_response_of1.43351266
53MP0001727_abnormal_embryo_implantation1.42128954
54MP0003567_abnormal_fetal_cardiomyocyte1.38998517
55MP0002277_abnormal_respiratory_mucosa1.37440134
56MP0002736_abnormal_nociception_after1.36864542
57MP0003186_abnormal_redox_activity1.36826519
58MP0002638_abnormal_pupillary_reflex1.35874554
59MP0009046_muscle_twitch1.34487661
60MP0008058_abnormal_DNA_repair1.34254134
61MP0002106_abnormal_muscle_physiology1.34197397
62MP0004924_abnormal_behavior1.33563710
63MP0005386_behavior/neurological_phenoty1.33563710
64MP0000747_muscle_weakness1.32267074
65MP0004957_abnormal_blastocyst_morpholog1.32187152
66MP0002064_seizures1.30070574
67MP0001968_abnormal_touch/_nociception1.29608284
68MP0001984_abnormal_olfaction1.29571456
69MP0004085_abnormal_heartbeat1.29317278
70MP0003315_abnormal_perineum_morphology1.29001374
71MP0002822_catalepsy1.27701778
72MP0009745_abnormal_behavioral_response1.26778935
73MP0001485_abnormal_pinna_reflex1.26521533
74MP0005385_cardiovascular_system_phenoty1.24927758
75MP0001544_abnormal_cardiovascular_syste1.24927758
76MP0004087_abnormal_muscle_fiber1.24038433
77MP0003938_abnormal_ear_development1.20988381
78MP0008995_early_reproductive_senescence1.20763858
79MP0003941_abnormal_skin_development1.20678977
80MP0004270_analgesia1.20443807
81MP0005377_hearing/vestibular/ear_phenot1.20082936
82MP0003878_abnormal_ear_physiology1.20082936
83MP0000372_irregular_coat_pigmentation1.19014262
84MP0006138_congestive_heart_failure1.18148934
85MP0005084_abnormal_gallbladder_morpholo1.17915738
86MP0005083_abnormal_biliary_tract1.17843283
87MP0005332_abnormal_amino_acid1.17286540
88MP0004742_abnormal_vestibular_system1.17224617
89MP0002234_abnormal_pharynx_morphology1.16181896
90MP0005266_abnormal_metabolism1.14459810
91MP0004130_abnormal_muscle_cell1.14394929
92MP0002734_abnormal_mechanical_nocicepti1.13676367
93MP0001486_abnormal_startle_reflex1.12771281
94MP0005369_muscle_phenotype1.10191886
95MP0000026_abnormal_inner_ear1.09772535
96MP0002160_abnormal_reproductive_system1.08658706
97MP0006072_abnormal_retinal_apoptosis1.07556752
98MP0003890_abnormal_embryonic-extraembry1.06279383
99MP0008875_abnormal_xenobiotic_pharmacok1.05934841
100MP0003718_maternal_effect1.05586702
101MP0005253_abnormal_eye_physiology1.04969226
102MP0003221_abnormal_cardiomyocyte_apopto1.04481522
103MP0001286_abnormal_eye_development1.03622740
104MP0005409_darkened_coat_color1.02822727
105MP0002735_abnormal_chemical_nociception1.02107197
106MP0005360_urolithiasis1.01143361
107MP0004381_abnormal_hair_follicle1.00369512
108MP0005645_abnormal_hypothalamus_physiol1.00086547
109MP0001970_abnormal_pain_threshold0.99699219
110MP0002557_abnormal_social/conspecific_i0.99252647
111MP0005535_abnormal_body_temperature0.98258410
112MP0005423_abnormal_somatic_nervous0.98042877
113MP0002184_abnormal_innervation0.98037571
114MP0004885_abnormal_endolymph0.97296697
115MP0000230_abnormal_systemic_arterial0.97037862
116MP0005379_endocrine/exocrine_gland_phen0.96230352
117MP0000759_abnormal_skeletal_muscle0.95589672
118MP0002102_abnormal_ear_morphology0.95305410
119MP0005085_abnormal_gallbladder_physiolo0.94844308
120MP0000955_abnormal_spinal_cord0.94697796
121MP0002067_abnormal_sensory_capabilities0.94642260
122MP0008932_abnormal_embryonic_tissue0.92865990
123MP0005171_absent_coat_pigmentation0.91853045
124MP0001661_extended_life_span0.91695141
125MP0002572_abnormal_emotion/affect_behav0.90190817
126MP0005195_abnormal_posterior_eye0.88716919
127MP0002229_neurodegeneration0.88080302
128MP0002697_abnormal_eye_size0.87107728
129MP0002233_abnormal_nose_morphology0.86415414
130MP0003937_abnormal_limbs/digits/tail_de0.85963799
131MP0003329_amyloid_beta_deposits0.84323278
132MP0008872_abnormal_physiological_respon0.83565852
133MP0002210_abnormal_sex_determination0.82273487
134MP0002751_abnormal_autonomic_nervous0.82018649
135MP0002127_abnormal_cardiovascular_syste0.81991830
136MP0005165_increased_susceptibility_to0.81955031
137MP0005551_abnormal_eye_electrophysiolog0.81759458
138MP0001501_abnormal_sleep_pattern0.81674237
139MP0005389_reproductive_system_phenotype0.80454797
140MP0001963_abnormal_hearing_physiology0.80092410
141MP0002269_muscular_atrophy0.79562185
142MP0005636_abnormal_mineral_homeostasis0.78959287
143MP0004133_heterotaxia0.78870073
144MP0004185_abnormal_adipocyte_glucose0.77995400
145MP0002733_abnormal_thermal_nociception0.77667765
146MP0002095_abnormal_skin_pigmentation0.77412375
147MP0005666_abnormal_adipose_tissue0.77404944
148MP0003119_abnormal_digestive_system0.77279445
149MP0004147_increased_porphyrin_level0.77217785
150MP0003635_abnormal_synaptic_transmissio0.77166544
151MP0000778_abnormal_nervous_system0.76183546
152MP0002066_abnormal_motor_capabilities/c0.72042808
153MP0002752_abnormal_somatic_nervous0.71351450
154MP0003011_delayed_dark_adaptation0.70813497
155MP0003690_abnormal_glial_cell0.68812366
156MP0005376_homeostasis/metabolism_phenot0.67995989

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.92358103
2Abnormal mitochondria in muscle tissue (HP:0008316)7.23317199
3Acute encephalopathy (HP:0006846)6.72547492
4Progressive macrocephaly (HP:0004481)6.65766904
5Mitochondrial inheritance (HP:0001427)6.51534642
6Increased CSF lactate (HP:0002490)5.60987003
7Hepatocellular necrosis (HP:0001404)5.44348287
8Cerebral edema (HP:0002181)5.18256442
9Hepatic necrosis (HP:0002605)5.11057785
10Increased hepatocellular lipid droplets (HP:0006565)4.91957214
11Lipid accumulation in hepatocytes (HP:0006561)4.65996122
12Abnormality of glycolysis (HP:0004366)4.39826842
13Increased serum pyruvate (HP:0003542)4.39826842
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.21980670
15Leukodystrophy (HP:0002415)4.21945194
16Respiratory failure (HP:0002878)4.15546303
17Increased intramyocellular lipid droplets (HP:0012240)4.15371986
18Renal Fanconi syndrome (HP:0001994)4.13630234
19Exercise intolerance (HP:0003546)4.04523371
20Optic disc pallor (HP:0000543)4.02185373
21Lactic acidosis (HP:0003128)3.95491520
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.85458131
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.85458131
24Increased muscle lipid content (HP:0009058)3.79843076
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.62978386
263-Methylglutaconic aciduria (HP:0003535)3.56867106
27Septo-optic dysplasia (HP:0100842)3.45382776
28Increased serum lactate (HP:0002151)3.36721424
29Abnormality of cells of the erythroid lineage (HP:0012130)3.12335490
30Muscle hypertrophy of the lower extremities (HP:0008968)3.09774002
31Sudden death (HP:0001699)3.07263475
32Calf muscle hypertrophy (HP:0008981)2.98528143
33Exertional dyspnea (HP:0002875)2.93702221
34Congenital, generalized hypertrichosis (HP:0004540)2.92127617
35Pheochromocytoma (HP:0002666)2.86381195
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83678834
37Lethargy (HP:0001254)2.83112300
38Parakeratosis (HP:0001036)2.82732008
39Neuroendocrine neoplasm (HP:0100634)2.78052320
40X-linked dominant inheritance (HP:0001423)2.76682829
41Abnormality of renal resorption (HP:0011038)2.69548457
42Respiratory difficulties (HP:0002880)2.65245344
43Abnormality of urine glucose concentration (HP:0011016)2.64075691
44Glycosuria (HP:0003076)2.64075691
45Palpitations (HP:0001962)2.63766192
46Abnormal number of erythroid precursors (HP:0012131)2.61963975
47CNS demyelination (HP:0007305)2.53894209
48Colon cancer (HP:0003003)2.53152814
49Macrocytic anemia (HP:0001972)2.53017987
50Pancreatic fibrosis (HP:0100732)2.52128268
51Sensory axonal neuropathy (HP:0003390)2.45813432
52Myokymia (HP:0002411)2.39596042
53Hyperglycinemia (HP:0002154)2.39378014
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38863754
55Dicarboxylic aciduria (HP:0003215)2.38863754
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33354247
57Absent septum pellucidum (HP:0001331)2.33203111
58Conjunctival hamartoma (HP:0100780)2.32395444
59Muscle fiber splitting (HP:0003555)2.30939190
60Hyperphosphaturia (HP:0003109)2.29194809
61Abnormality of midbrain morphology (HP:0002418)2.25841397
62Molar tooth sign on MRI (HP:0002419)2.25841397
63Abnormality of the labia minora (HP:0012880)2.24884983
64Ventricular tachycardia (HP:0004756)2.24219401
65Maternal diabetes (HP:0009800)2.23991636
66Methylmalonic acidemia (HP:0002912)2.21164110
67Sclerocornea (HP:0000647)2.19179889
68Methylmalonic aciduria (HP:0012120)2.18498021
69Congenital ichthyosiform erythroderma (HP:0007431)2.16507192
70Vomiting (HP:0002013)2.15955445
71Pancreatic cysts (HP:0001737)2.15546390
72Exercise-induced myalgia (HP:0003738)2.15378306
73Emotional lability (HP:0000712)2.14667094
74Myoglobinuria (HP:0002913)2.10677527
75Medial flaring of the eyebrow (HP:0010747)2.08417498
76True hermaphroditism (HP:0010459)2.07471516
77Abnormality of the calf musculature (HP:0001430)2.07316148
78Abnormal urine phosphate concentration (HP:0012599)2.04370888
79Stenosis of the external auditory canal (HP:0000402)2.04364487
80Myotonia (HP:0002486)2.03455707
81Progressive external ophthalmoplegia (HP:0000590)2.02842719
82Rhabdomyolysis (HP:0003201)2.01407486
83Reticulocytopenia (HP:0001896)2.01171953
84Oral leukoplakia (HP:0002745)1.94566711
85Muscle stiffness (HP:0003552)1.94384678
86Depressed nasal ridge (HP:0000457)1.93691776
87Cerebral hemorrhage (HP:0001342)1.92327217
88Exercise-induced muscle cramps (HP:0003710)1.91417059
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88834782
90Degeneration of the lateral corticospinal tracts (HP:0002314)1.88834782
91Abnormality of the septum pellucidum (HP:0007375)1.88708164
92Rib fusion (HP:0000902)1.87395120
93Partial duplication of thumb phalanx (HP:0009944)1.86787021
94Ragged-red muscle fibers (HP:0003200)1.85446612
95Gait imbalance (HP:0002141)1.83230588
96Prolonged QT interval (HP:0001657)1.81848112
97Hyperglycinuria (HP:0003108)1.81454874
98Abnormality of placental membranes (HP:0011409)1.78391620
99Amniotic constriction ring (HP:0009775)1.78391620
100Blindness (HP:0000618)1.77905171
101Nephronophthisis (HP:0000090)1.77848597
102Aplastic anemia (HP:0001915)1.77288483
103Congenital primary aphakia (HP:0007707)1.77244515
104Syncope (HP:0001279)1.77059542
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76817712
106Abnormality of alanine metabolism (HP:0010916)1.76817712
107Hyperalaninemia (HP:0003348)1.76817712
108Hyporeflexia of lower limbs (HP:0002600)1.76761048
109Lipoatrophy (HP:0100578)1.76175538
110Limb dystonia (HP:0002451)1.76135506
111Triphalangeal thumb (HP:0001199)1.75312609
112Anophthalmia (HP:0000528)1.74849509
113Optic nerve hypoplasia (HP:0000609)1.74505411
114Abnormality of serum amino acid levels (HP:0003112)1.74131803
115Abnormality of fatty-acid metabolism (HP:0004359)1.71570783
116Atrial fibrillation (HP:0005110)1.70722994
117Partial duplication of the phalanx of hand (HP:0009999)1.69520544
118Abnormal hemoglobin (HP:0011902)1.68791541
119Absent thumb (HP:0009777)1.68293967
120Dilated cardiomyopathy (HP:0001644)1.68245857
121Pallor (HP:0000980)1.67767494
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66709170
123Gliosis (HP:0002171)1.66345300
124Supraventricular tachycardia (HP:0004755)1.66242846
125Hypoplastic left heart (HP:0004383)1.65423448
126EMG: myopathic abnormalities (HP:0003458)1.63979675
127Pendular nystagmus (HP:0012043)1.63898653
128Nephrogenic diabetes insipidus (HP:0009806)1.63356550
129Microvesicular hepatic steatosis (HP:0001414)1.63298951
130Abnormal pupillary function (HP:0007686)1.63006236
131Generalized aminoaciduria (HP:0002909)1.62319058
132Renal tubular dysfunction (HP:0000124)1.62155889
133Primary atrial arrhythmia (HP:0001692)1.61359005
134Male pseudohermaphroditism (HP:0000037)1.60893122
135Vaginal atresia (HP:0000148)1.60311729
136Poor suck (HP:0002033)1.59768470
137Abnormality of glycine metabolism (HP:0010895)1.59659415
138Abnormality of serine family amino acid metabolism (HP:0010894)1.59659415
139Concave nail (HP:0001598)1.59172808
140Anencephaly (HP:0002323)1.59128453
141Supraventricular arrhythmia (HP:0005115)1.58587117
142Ketoacidosis (HP:0001993)1.58227211
143Neoplasm of head and neck (HP:0012288)1.57316902
144Genital tract atresia (HP:0001827)1.55984286
145Bilateral microphthalmos (HP:0007633)1.53676307
146Cleft eyelid (HP:0000625)1.49323026
147Megaloblastic anemia (HP:0001889)1.47453178
148Abnormal number of incisors (HP:0011064)1.47194545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.29226661
2NME24.05891356
3STK393.89430387
4NME13.32056776
5MYLK2.88501485
6CDC72.80455371
7OXSR12.64200526
8PNCK2.62531963
9PBK2.50108868
10OBSCN2.47474831
11WNK42.47420031
12MST42.32702011
13ARAF2.22596342
14GRK72.15727475
15MUSK2.10990232
16LIMK11.99223575
17BCKDK1.95366161
18STK161.91495555
19TAF11.89670860
20MAP3K121.86058905
21BCR1.85059298
22CASK1.67752601
23PHKG21.66417886
24PHKG11.66417886
25NEK11.63212526
26GRK51.57180302
27DYRK31.57041115
28TLK11.44871381
29CAMK2D1.44572543
30BUB11.43528325
31PDK41.43143531
32PDK31.43143531
33PIK3CA1.42272439
34CDK191.36363503
35PASK1.35012945
36PLK41.30314544
37MAP4K21.29443479
38PKN11.28701060
39GRK11.28495613
40INSRR1.23450488
41TNIK1.18539697
42VRK11.16761726
43CAMK2B1.15952530
44NUAK11.15644268
45ADRBK21.13091305
46UHMK11.11662619
47PINK11.10450396
48LMTK21.09490020
49DAPK31.08436272
50ABL21.07113959
51CAMK2A1.06152347
52PLK31.05316606
53CAMK2G1.05207435
54ROCK21.05145631
55PDK21.04510019
56PRKCG1.02221131
57MAPKAPK51.01519130
58BMPR1B1.00962255
59AURKB0.99637930
60PLK10.97681816
61MKNK10.96283868
62TTN0.96120837
63DYRK20.95717257
64CSNK1G30.92874596
65ILK0.92760706
66ADRBK10.91279073
67LRRK20.84241190
68TTK0.83037309
69TRIM280.82934120
70FGR0.82305860
71PAK30.81613731
72BRAF0.81423691
73NTRK20.79485910
74CHEK20.78954146
75MARK10.78778340
76MINK10.78246115
77TESK20.76559219
78WNK30.76121307
79MET0.75669047
80MST1R0.75170041
81MAPK150.70678924
82CSNK1E0.69990805
83PRKACA0.68755555
84WEE10.68684122
85STK240.65918302
86MKNK20.65238429
87PRKCE0.63228843
88TIE10.61304689
89EPHA40.60817228
90NEK20.60440864
91MAP2K20.58505599
92CDK140.56180912
93AURKA0.55686126
94EIF2AK10.55377278
95KSR20.55083047
96DYRK1B0.54459935
97SRPK10.54369206
98ROCK10.53622300
99MAP3K90.53093964
100MAP3K40.52101122
101CSNK1G10.51945722
102CSNK1A10.51613838
103WNK10.51452426
104PIM20.50842198
105CAMK10.49468903
106IRAK20.49205541
107CSNK2A20.48821508
108ATR0.47804597
109CDK30.47037423
110RPS6KA50.46454963
111STK40.45913673
112STK38L0.45423389
113MAPK130.44582978
114CDK80.41780695
115CSNK1G20.41581492
116MAPK120.41201765
117PRKCQ0.41114500
118PLK20.40562415
119EPHB20.40546445
120BRSK10.40234979
121MAP2K70.38410600
122CDK150.38353090
123PIK3CG0.37767986
124ZAK0.37414637
125CSNK2A10.37301549
126ERBB40.36973900
127CDK180.36150376
128CDK11A0.35746958
129MAP2K40.34917195
130PAK10.34768418
131MOS0.34586783
132PRKACB0.34574658
133CSNK1A1L0.34480591
134PRKD10.33767115
135PRKG10.32540656
136NEK60.32506951

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.63139006
2Parkinsons disease_Homo sapiens_hsa050125.74250737
3Alzheimers disease_Homo sapiens_hsa050104.34758495
4Huntingtons disease_Homo sapiens_hsa050164.02427686
5Ribosome_Homo sapiens_hsa030103.78381380
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.73561153
7* Cardiac muscle contraction_Homo sapiens_hsa042603.25715127
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47332046
9Proteasome_Homo sapiens_hsa030502.39356973
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34467581
11Fatty acid elongation_Homo sapiens_hsa000622.20199257
12Mismatch repair_Homo sapiens_hsa034301.97522653
13Propanoate metabolism_Homo sapiens_hsa006401.91235812
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86084724
15Sulfur metabolism_Homo sapiens_hsa009201.86060743
16Protein export_Homo sapiens_hsa030601.78993599
17DNA replication_Homo sapiens_hsa030301.78474505
18RNA polymerase_Homo sapiens_hsa030201.70431668
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59959579
20Pyruvate metabolism_Homo sapiens_hsa006201.58955823
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49824281
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45547239
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40940769
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38340014
25Butanoate metabolism_Homo sapiens_hsa006501.38100870
26Carbon metabolism_Homo sapiens_hsa012001.24742262
27Collecting duct acid secretion_Homo sapiens_hsa049661.21097167
28Steroid biosynthesis_Homo sapiens_hsa001001.21017515
29RNA degradation_Homo sapiens_hsa030181.17678895
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12617508
31Base excision repair_Homo sapiens_hsa034101.04879542
32Fatty acid degradation_Homo sapiens_hsa000711.01743569
33One carbon pool by folate_Homo sapiens_hsa006701.00931953
34RNA transport_Homo sapiens_hsa030130.96584692
35Glutathione metabolism_Homo sapiens_hsa004800.96106459
36Fanconi anemia pathway_Homo sapiens_hsa034600.94567806
37* Metabolic pathways_Homo sapiens_hsa011000.93885021
38Fatty acid metabolism_Homo sapiens_hsa012120.93842989
39Peroxisome_Homo sapiens_hsa041460.91437426
40Phenylalanine metabolism_Homo sapiens_hsa003600.90729849
41Tyrosine metabolism_Homo sapiens_hsa003500.87856568
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84503436
43Linoleic acid metabolism_Homo sapiens_hsa005910.83271993
44Ether lipid metabolism_Homo sapiens_hsa005650.79221012
45Arginine and proline metabolism_Homo sapiens_hsa003300.76781887
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76285993
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.73306642
48Pyrimidine metabolism_Homo sapiens_hsa002400.73127657
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69626496
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68270432
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67296529
52Vibrio cholerae infection_Homo sapiens_hsa051100.67081108
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66849876
54Histidine metabolism_Homo sapiens_hsa003400.63044887
55Basal cell carcinoma_Homo sapiens_hsa052170.61295133
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60865320
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60333108
58Arachidonic acid metabolism_Homo sapiens_hsa005900.59839476
59Chemical carcinogenesis_Homo sapiens_hsa052040.58166765
60beta-Alanine metabolism_Homo sapiens_hsa004100.57236351
61Sulfur relay system_Homo sapiens_hsa041220.57035113
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55769868
63Folate biosynthesis_Homo sapiens_hsa007900.54999365
64PPAR signaling pathway_Homo sapiens_hsa033200.54734141
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53729798
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.53604758
67Nitrogen metabolism_Homo sapiens_hsa009100.52839434
68Vitamin digestion and absorption_Homo sapiens_hsa049770.52293285
69Tryptophan metabolism_Homo sapiens_hsa003800.48514373
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48254827
71Nicotine addiction_Homo sapiens_hsa050330.46380673
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45738037
73Dilated cardiomyopathy_Homo sapiens_hsa054140.44999393
74Alcoholism_Homo sapiens_hsa050340.43773163
75Biosynthesis of amino acids_Homo sapiens_hsa012300.41712121
76Asthma_Homo sapiens_hsa053100.40692708
77Fat digestion and absorption_Homo sapiens_hsa049750.38745608
78Morphine addiction_Homo sapiens_hsa050320.37855940
79Purine metabolism_Homo sapiens_hsa002300.37780766
80Caffeine metabolism_Homo sapiens_hsa002320.37431241
81Hedgehog signaling pathway_Homo sapiens_hsa043400.36621176
82Serotonergic synapse_Homo sapiens_hsa047260.36587129
83Cell cycle_Homo sapiens_hsa041100.36431582
84Selenocompound metabolism_Homo sapiens_hsa004500.34893622
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31996286
86Non-homologous end-joining_Homo sapiens_hsa034500.30999815
87Phototransduction_Homo sapiens_hsa047440.29121891
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.28739251
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28689582
90Olfactory transduction_Homo sapiens_hsa047400.27772167
91Rheumatoid arthritis_Homo sapiens_hsa053230.26495061
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26302769
93Retinol metabolism_Homo sapiens_hsa008300.25328572
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.22683406
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22381424
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21680321
97Glutamatergic synapse_Homo sapiens_hsa047240.21334047
98mRNA surveillance pathway_Homo sapiens_hsa030150.21200645
99Taste transduction_Homo sapiens_hsa047420.20614905
100Pentose phosphate pathway_Homo sapiens_hsa000300.20393495
101GABAergic synapse_Homo sapiens_hsa047270.19844264
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19041341
103Homologous recombination_Homo sapiens_hsa034400.17606526
104Spliceosome_Homo sapiens_hsa030400.17550275
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16410135
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15286357
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13089171
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12911704
109Basal transcription factors_Homo sapiens_hsa030220.12645293
110Nucleotide excision repair_Homo sapiens_hsa034200.12117337
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.11617459
112Vitamin B6 metabolism_Homo sapiens_hsa007500.11280740
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11063410
114Starch and sucrose metabolism_Homo sapiens_hsa005000.10653547
115Synaptic vesicle cycle_Homo sapiens_hsa047210.10240598
116Sphingolipid metabolism_Homo sapiens_hsa006000.08693397
117Fructose and mannose metabolism_Homo sapiens_hsa000510.08429018
118Calcium signaling pathway_Homo sapiens_hsa040200.08268880
119Systemic lupus erythematosus_Homo sapiens_hsa053220.07645689
120Mineral absorption_Homo sapiens_hsa049780.07329795
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.07041377
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.06303928
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05899726
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.05118843
125Arginine biosynthesis_Homo sapiens_hsa002200.04689455
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.04393072
127Regulation of autophagy_Homo sapiens_hsa041400.03860445

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