COX7CP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)6.40344130
2UMP metabolic process (GO:0046049)6.40344130
3pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)6.40344130
4UMP biosynthetic process (GO:0006222)6.40344130
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.08630833
6nucleotide salvage (GO:0043173)5.68234584
7maturation of SSU-rRNA (GO:0030490)5.57274663
8pyrimidine-containing compound salvage (GO:0008655)5.45232880
9pyrimidine nucleoside salvage (GO:0043097)5.45232880
10inner ear receptor cell differentiation (GO:0060113)5.40121512
11behavioral response to nicotine (GO:0035095)5.12298865
12mitochondrion transport along microtubule (GO:0047497)5.08998858
13establishment of mitochondrion localization, microtubule-mediated (GO:0034643)5.08998858
14establishment of mitochondrion localization (GO:0051654)5.04340400
15pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)5.02896616
16pyrimidine nucleoside monophosphate metabolic process (GO:0009129)4.89015125
17nucleoside salvage (GO:0043174)4.77359951
18pentose metabolic process (GO:0019321)4.63536754
19pyrimidine nucleobase catabolic process (GO:0006208)4.63120574
20regulation of glycogen (starch) synthase activity (GO:2000465)4.54037101
21head development (GO:0060322)4.47204588
22viral transcription (GO:0019083)4.36240540
23calcium ion-dependent exocytosis (GO:0017156)4.35424428
24ribosomal small subunit assembly (GO:0000028)4.32166907
25translational termination (GO:0006415)4.26020673
26mechanoreceptor differentiation (GO:0042490)4.22923387
27regulation of cilium movement (GO:0003352)4.13918479
28CTP metabolic process (GO:0046036)4.05846789
29CTP biosynthetic process (GO:0006241)4.05846789
30keratinocyte development (GO:0003334)4.01650684
31cell-cell junction maintenance (GO:0045217)4.00434455
32terpenoid biosynthetic process (GO:0016114)3.89355426
33diterpenoid biosynthetic process (GO:0016102)3.83153892
34nucleobase catabolic process (GO:0046113)3.77819220
35translational elongation (GO:0006414)3.73181054
36photoreceptor cell maintenance (GO:0045494)3.66120408
37epithelial cilium movement (GO:0003351)3.64153643
38pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.58803071
39regulation of microtubule-based movement (GO:0060632)3.50285956
40cell proliferation in forebrain (GO:0021846)3.46675554
41ribosomal small subunit biogenesis (GO:0042274)3.45447467
42pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.39824976
43cellular protein complex disassembly (GO:0043624)3.38050662
44activation of NF-kappaB-inducing kinase activity (GO:0007250)3.35089455
45cell junction maintenance (GO:0034331)3.34856012
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31209790
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31209790
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28738812
49cotranslational protein targeting to membrane (GO:0006613)3.22147396
50protein targeting to ER (GO:0045047)3.20572537
51catecholamine transport (GO:0051937)3.17813836
52axoneme assembly (GO:0035082)3.16250110
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12809764
54protein polyglutamylation (GO:0018095)3.08188264
55viral life cycle (GO:0019058)3.07399948
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06953265
57positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.05113084
58auditory receptor cell differentiation (GO:0042491)3.04947642
59postsynaptic membrane organization (GO:0001941)3.01798139
60glyoxylate metabolic process (GO:0046487)2.98962053
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98499727
62pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.97462379
63acrosome reaction (GO:0007340)2.97280802
64synaptic transmission, cholinergic (GO:0007271)2.96537955
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96264016
66protein localization to endoplasmic reticulum (GO:0070972)2.95481469
67pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.93959008
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.92301193
69regulation of activation of Janus kinase activity (GO:0010533)2.92011204
70protein complex disassembly (GO:0043241)2.86083508
71camera-type eye morphogenesis (GO:0048593)2.84612516
72peptidyl-lysine trimethylation (GO:0018023)2.84005403
73axonemal dynein complex assembly (GO:0070286)2.81764653
74pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.76501174
75parturition (GO:0007567)2.75994092
76negative regulation of keratinocyte proliferation (GO:0010839)2.74963382
77macromolecular complex disassembly (GO:0032984)2.73263006
78transmission of nerve impulse (GO:0019226)2.70160271
79regulation of meiosis I (GO:0060631)2.68357003
80oxidative demethylation (GO:0070989)2.67961589
81sperm motility (GO:0030317)2.61460391
82drug catabolic process (GO:0042737)2.59582951
83cilium movement (GO:0003341)2.58871283
84positive regulation of meiosis (GO:0045836)2.58456220
85phenylpropanoid metabolic process (GO:0009698)2.57581273
86protein-chromophore linkage (GO:0018298)2.57159785
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.55888364
88peptidyl-cysteine modification (GO:0018198)2.51563973
89positive regulation of sodium ion transmembrane transport (GO:1902307)2.51435248
90pyrimidine ribonucleotide metabolic process (GO:0009218)2.50980316
91negative regulation of telomere maintenance (GO:0032205)2.49315982
92dopamine transport (GO:0015872)2.48624237
93DNA dealkylation (GO:0035510)2.48363375
94neuronal action potential (GO:0019228)2.47519937
95negative regulation of sodium ion transport (GO:0010766)2.46922920
96phosphorelay signal transduction system (GO:0000160)2.46338428
97somite development (GO:0061053)2.45224238
98neuromuscular synaptic transmission (GO:0007274)2.43370640
99positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.42938106
100organic cation transport (GO:0015695)2.42673064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43544948
2IKZF1_21737484_ChIP-ChIP_HCT116_Human3.06999387
3ZNF274_21170338_ChIP-Seq_K562_Hela2.81291293
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40401949
5REST_21632747_ChIP-Seq_MESCs_Mouse2.30373112
6IGF1R_20145208_ChIP-Seq_DFB_Human2.22335789
7VDR_22108803_ChIP-Seq_LS180_Human2.19304736
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12562358
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.04683363
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91776492
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90678861
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86147077
13GBX2_23144817_ChIP-Seq_PC3_Human1.85197818
14IRF1_19129219_ChIP-ChIP_H3396_Human1.84853501
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80800126
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.78814969
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75992345
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.75771511
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71278408
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69636858
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69047149
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.68830883
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68719728
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64935927
25P53_22127205_ChIP-Seq_FIBROBLAST_Human1.61825994
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60673478
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.60190223
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58581241
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55951912
30RNF2_27304074_Chip-Seq_NSC_Mouse1.52031080
31FUS_26573619_Chip-Seq_HEK293_Human1.51292412
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48618589
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47146133
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45483953
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44746761
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41379886
37P300_19829295_ChIP-Seq_ESCs_Human1.40635522
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40432403
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39020551
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37645358
41ERA_21632823_ChIP-Seq_H3396_Human1.33453674
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33194912
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33059784
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31801955
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31801955
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.30674854
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.26531609
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26237458
49CBP_20019798_ChIP-Seq_JUKART_Human1.26237458
50TP53_22573176_ChIP-Seq_HFKS_Human1.26012872
51SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22897218
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.21973694
53SMAD3_21741376_ChIP-Seq_ESCs_Human1.20393287
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19881724
55BCAT_22108803_ChIP-Seq_LS180_Human1.19074230
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17452732
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17286378
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.17111285
59AR_20517297_ChIP-Seq_VCAP_Human1.16192079
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15793284
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14263328
62TAF15_26573619_Chip-Seq_HEK293_Human1.14109114
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13883635
64DROSHA_22980978_ChIP-Seq_HELA_Human1.13790849
65TCF4_23295773_ChIP-Seq_U87_Human1.12671569
66EWS_26573619_Chip-Seq_HEK293_Human1.11243456
67NCOR_22424771_ChIP-Seq_293T_Human1.09767923
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09659186
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09197940
70MYC_19829295_ChIP-Seq_ESCs_Human1.09104157
71ER_23166858_ChIP-Seq_MCF-7_Human1.08574275
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08507629
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08450195
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08129849
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08056681
76E2F1_20622854_ChIP-Seq_HELA_Human1.07820945
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06848353
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06816780
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06581381
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06404386
81CTCF_27219007_Chip-Seq_Bcells_Human1.05387965
82SMAD4_21799915_ChIP-Seq_A2780_Human1.05155311
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.04855523
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02036934
85RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01948202
86RUNX2_22187159_ChIP-Seq_PCA_Human1.01809792
87SOX2_19829295_ChIP-Seq_ESCs_Human1.00358701
88NANOG_19829295_ChIP-Seq_ESCs_Human1.00358701
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.99740565
90TAF2_19829295_ChIP-Seq_ESCs_Human0.99167161
91STAT3_23295773_ChIP-Seq_U87_Human0.98775976
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98764763
93RAC3_21632823_ChIP-Seq_H3396_Human0.98658010
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98169641
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.96749336
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95439251
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95400767
98JUN_21703547_ChIP-Seq_K562_Human0.94972127
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94173151
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93787563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001485_abnormal_pinna_reflex3.69739979
2MP0003646_muscle_fatigue3.67614327
3MP0006292_abnormal_olfactory_placode3.09523356
4MP0004742_abnormal_vestibular_system3.02335632
5MP0006276_abnormal_autonomic_nervous2.93110414
6MP0008875_abnormal_xenobiotic_pharmacok2.80703822
7MP0003122_maternal_imprinting2.60645988
8MP0009379_abnormal_foot_pigmentation2.43610521
9MP0003787_abnormal_imprinting2.37365932
10MP0002163_abnormal_gland_morphology2.37037189
11MP0003136_yellow_coat_color2.30786018
12MP0003880_abnormal_central_pattern2.18650304
13MP0001293_anophthalmia2.06511666
14MP0001529_abnormal_vocalization2.05229632
15MP0003879_abnormal_hair_cell1.99509517
16MP0008872_abnormal_physiological_respon1.91934600
17MP0000778_abnormal_nervous_system1.85399738
18MP0008877_abnormal_DNA_methylation1.85130666
19MP0004142_abnormal_muscle_tone1.84576179
20MP0001986_abnormal_taste_sensitivity1.84212151
21MP0004885_abnormal_endolymph1.72599357
22MP0002735_abnormal_chemical_nociception1.68783589
23MP0003121_genomic_imprinting1.67567375
24MP0004133_heterotaxia1.65650436
25MP0003878_abnormal_ear_physiology1.65457916
26MP0005377_hearing/vestibular/ear_phenot1.65457916
27MP0004270_analgesia1.61453471
28MP0009745_abnormal_behavioral_response1.60188180
29MP0003123_paternal_imprinting1.58300536
30MP0002272_abnormal_nervous_system1.56590966
31MP0002734_abnormal_mechanical_nocicepti1.50070571
32MP0005360_urolithiasis1.48119373
33MP0005646_abnormal_pituitary_gland1.46400887
34MP0009046_muscle_twitch1.46314934
35MP0008789_abnormal_olfactory_epithelium1.46221639
36MP0001968_abnormal_touch/_nociception1.46112506
37MP0000372_irregular_coat_pigmentation1.43286970
38MP0002638_abnormal_pupillary_reflex1.41236234
39MP0002736_abnormal_nociception_after1.36197627
40MP0003635_abnormal_synaptic_transmissio1.35659689
41MP0005379_endocrine/exocrine_gland_phen1.33790312
42MP0002876_abnormal_thyroid_physiology1.32859989
43MP0002160_abnormal_reproductive_system1.28543397
44MP0001486_abnormal_startle_reflex1.26526667
45MP0002067_abnormal_sensory_capabilities1.24578469
46MP0005499_abnormal_olfactory_system1.23999290
47MP0005394_taste/olfaction_phenotype1.23999290
48MP0000631_abnormal_neuroendocrine_gland1.22999017
49MP0002557_abnormal_social/conspecific_i1.22329926
50MP0002653_abnormal_ependyma_morphology1.21882585
51MP0001346_abnormal_lacrimal_gland1.21457491
52MP0004145_abnormal_muscle_electrophysio1.21411204
53MP0001348_abnormal_lacrimal_gland1.20611521
54MP0005645_abnormal_hypothalamus_physiol1.20386497
55MP0010386_abnormal_urinary_bladder1.20117756
56MP0005551_abnormal_eye_electrophysiolog1.19847277
57MP0002938_white_spotting1.19173636
58MP0003195_calcinosis1.18562304
59MP0001970_abnormal_pain_threshold1.18127731
60MP0001963_abnormal_hearing_physiology1.17036760
61MP0000026_abnormal_inner_ear1.14934392
62MP0002063_abnormal_learning/memory/cond1.14686085
63MP0000955_abnormal_spinal_cord1.13814056
64MP0005167_abnormal_blood-brain_barrier1.10232725
65MP0002095_abnormal_skin_pigmentation1.06757947
66MP0000538_abnormal_urinary_bladder1.06638195
67MP0002572_abnormal_emotion/affect_behav1.04452892
68MP0005389_reproductive_system_phenotype1.04049418
69MP0002752_abnormal_somatic_nervous1.03673073
70MP0002064_seizures1.03356469
71MP0001984_abnormal_olfaction1.02227006
72MP0005423_abnormal_somatic_nervous1.02218181
73MP0005085_abnormal_gallbladder_physiolo1.02019057
74MP0002733_abnormal_thermal_nociception1.01745491
75MP0000427_abnormal_hair_cycle0.98993095
76MP0002882_abnormal_neuron_morphology0.98008587
77MP0004859_abnormal_synaptic_plasticity0.97952071
78MP0002102_abnormal_ear_morphology0.96509494
79MP0001905_abnormal_dopamine_level0.91482928
80MP0004043_abnormal_pH_regulation0.89595892
81MP0005195_abnormal_posterior_eye0.89569134
82MP0008775_abnormal_heart_ventricle0.88734621
83MP0004924_abnormal_behavior0.88371816
84MP0005386_behavior/neurological_phenoty0.88371816
85MP0002277_abnormal_respiratory_mucosa0.88270832
86MP0005310_abnormal_salivary_gland0.87031551
87MP0001919_abnormal_reproductive_system0.86119435
88MP0003942_abnormal_urinary_system0.83882485
89MP0005391_vision/eye_phenotype0.79962275
90MP0000049_abnormal_middle_ear0.79954189
91MP0002234_abnormal_pharynx_morphology0.79561753
92MP0002229_neurodegeneration0.79305086
93MP0003698_abnormal_male_reproductive0.76645623
94MP0006072_abnormal_retinal_apoptosis0.76593081
95MP0002152_abnormal_brain_morphology0.75868666
96MP0002184_abnormal_innervation0.75050599
97MP0002837_dystrophic_cardiac_calcinosis0.73644417
98MP0003252_abnormal_bile_duct0.73605866
99MP0002909_abnormal_adrenal_gland0.73298500
100MP0005174_abnormal_tail_pigmentation0.71494704

Predicted human phenotypes

RankGene SetZ-score
1Hip dysplasia (HP:0001385)4.70216432
2Hypoplasia of the pons (HP:0012110)4.58752939
3Abnormality of the pons (HP:0007361)4.04463877
4Reticulocytopenia (HP:0001896)3.90953877
5Chronic hepatic failure (HP:0100626)3.80791803
6Difficulty running (HP:0009046)3.62513288
7Type II lissencephaly (HP:0007260)3.56211952
8Abnormality of midbrain morphology (HP:0002418)3.34392337
9Molar tooth sign on MRI (HP:0002419)3.34392337
10Pancreatic fibrosis (HP:0100732)3.31841559
11Acute necrotizing encephalopathy (HP:0006965)2.98373682
12Hip contracture (HP:0003273)2.94148897
13Cerebellar dysplasia (HP:0007033)2.92425821
14Bifid tongue (HP:0010297)2.91927496
15Pancreatic cysts (HP:0001737)2.88911671
16Poor suck (HP:0002033)2.87859994
17Hyperglycinemia (HP:0002154)2.76668174
18Abnormality of the renal medulla (HP:0100957)2.75901260
19Abnormal respiratory epithelium morphology (HP:0012253)2.65892165
20Abnormal respiratory motile cilium morphology (HP:0005938)2.65892165
21Limited hip movement (HP:0008800)2.62893178
22Anophthalmia (HP:0000528)2.58625423
23Acute encephalopathy (HP:0006846)2.56390519
24Abnormal mitochondria in muscle tissue (HP:0008316)2.49752962
25Papilledema (HP:0001085)2.48919149
26Anterior segment dysgenesis (HP:0007700)2.47611457
27Progressive macrocephaly (HP:0004481)2.46833149
28Oligodactyly (hands) (HP:0001180)2.46561036
29Septo-optic dysplasia (HP:0100842)2.45692627
30Fetal akinesia sequence (HP:0001989)2.43740135
31Pendular nystagmus (HP:0012043)2.42588896
32Morphological abnormality of the middle ear (HP:0008609)2.42037659
33Hypoplasia of the brainstem (HP:0002365)2.41093899
34Aplasia/Hypoplasia of the brainstem (HP:0007362)2.41093899
35True hermaphroditism (HP:0010459)2.40933643
36Retinal dysplasia (HP:0007973)2.39019704
37Nephronophthisis (HP:0000090)2.35907803
38Genital tract atresia (HP:0001827)2.35339057
39Polyphagia (HP:0002591)2.34263873
40Aplasia/Hypoplasia of the sternum (HP:0006714)2.33637715
41Tubular atrophy (HP:0000092)2.33404254
42Chorioretinal atrophy (HP:0000533)2.32394315
43Tubulointerstitial nephritis (HP:0001970)2.31239417
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31025179
45Optic nerve hypoplasia (HP:0000609)2.30115672
46Mitochondrial inheritance (HP:0001427)2.29904078
47Bilateral microphthalmos (HP:0007633)2.27019283
48Restlessness (HP:0000711)2.26084878
49Vaginal atresia (HP:0000148)2.20803661
50Abnormality of the renal cortex (HP:0011035)2.17459727
51Increased CSF lactate (HP:0002490)2.15814731
52Congenital stationary night blindness (HP:0007642)2.14716731
53Renal dysplasia (HP:0000110)2.14232281
54Renovascular hypertension (HP:0100817)2.12679125
55Absent thumb (HP:0009777)2.12270123
56Dyskinesia (HP:0100660)2.11789343
57Lissencephaly (HP:0001339)2.11469635
58Hypoplasia of the ulna (HP:0003022)2.10574868
59Ectopic kidney (HP:0000086)2.10465888
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09444167
61Abnormality of cells of the erythroid lineage (HP:0012130)2.06219855
62Oligodactyly (HP:0012165)2.05458512
63Abnormality of the diencephalon (HP:0010662)2.04405169
64Cystic liver disease (HP:0006706)2.01277202
65Optic disc pallor (HP:0000543)1.95789570
66Volvulus (HP:0002580)1.95345316
67Wide intermamillary distance (HP:0006610)1.95282274
68Medial flaring of the eyebrow (HP:0010747)1.93517383
69Polydipsia (HP:0001959)1.92440136
70Abnormal drinking behavior (HP:0030082)1.92440136
71Agitation (HP:0000713)1.91655689
72Renal hypoplasia (HP:0000089)1.91492694
73Aplasia/Hypoplasia of the spleen (HP:0010451)1.90871908
74Optic nerve coloboma (HP:0000588)1.90211057
75Broad-based gait (HP:0002136)1.90093922
76Achilles tendon contracture (HP:0001771)1.88446990
77Abnormality of the labia minora (HP:0012880)1.87602399
78Pachygyria (HP:0001302)1.87501499
79Abnormality of the pubic bones (HP:0003172)1.87372891
80Short femoral neck (HP:0100864)1.86854772
81Tubulointerstitial abnormality (HP:0001969)1.85225008
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85024051
83Asplenia (HP:0001746)1.84229829
84Sclerocornea (HP:0000647)1.83654758
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.83283925
86Absent/shortened dynein arms (HP:0200106)1.83283925
87Rib fusion (HP:0000902)1.82419929
88Cerebral edema (HP:0002181)1.79509498
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.78821601
90Spastic tetraplegia (HP:0002510)1.78575304
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.78110242
92Abnormality of the aortic arch (HP:0012303)1.76891587
93Adrenal hypoplasia (HP:0000835)1.75804333
94Decreased central vision (HP:0007663)1.75400718
95Abnormality of the Achilles tendon (HP:0005109)1.75057162
96Increased hepatocellular lipid droplets (HP:0006565)1.74971498
97Bicornuate uterus (HP:0000813)1.73570857
98Potter facies (HP:0002009)1.73316739
99Facial shape deformation (HP:0011334)1.73316739
100Impaired smooth pursuit (HP:0007772)1.72804994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK25.93714884
2WNK35.07683612
3FRK3.99564085
4LIMK13.65454391
5WNK42.92687133
6NTRK22.83872327
7PRKD32.64064897
8CASK2.54068613
9NTRK12.42567881
10NEK22.23803817
11STK391.90814355
12TNIK1.84321515
13MAP4K21.82739386
14DYRK21.61276004
15PINK11.59928697
16NUAK11.58250902
17NTRK31.56309031
18MAP3K111.46841078
19PRKCG1.46276021
20MAP2K71.41720211
21TAF11.39390114
22MARK11.37906679
23MINK11.35754908
24GRK11.35275861
25TRIM281.30495066
26ADRBK21.26699209
27PLK21.16906624
28MAPK131.16142680
29INSRR1.14406546
30PKN11.08629447
31SIK31.06140042
32BCKDK1.03813352
33OXSR11.02477183
34CDK191.01601095
35SGK2230.98904001
36SGK4940.98904001
37PAK30.97073780
38NLK0.89395274
39STK110.85643403
40DYRK1A0.84166892
41TIE10.83535650
42CAMK10.80403012
43PRKCQ0.78998855
44TESK10.78827148
45BMPR1B0.77780479
46PIK3CA0.75219881
47MUSK0.72755817
48ACVR1B0.67851814
49BCR0.66084749
50SGK20.65629100
51MAP3K40.65114965
52MAP4K10.64608561
53WNK10.64550641
54PIK3CG0.64093951
55TLK10.63910831
56PLK40.63382953
57PRKCH0.62331904
58PHKG20.60033401
59PHKG10.60033401
60CSNK1A10.56952768
61PRKCE0.54571303
62CDC42BPA0.53458457
63ABL20.52207870
64CDK50.50095649
65PRKCZ0.48406865
66EPHA40.48214075
67CSNK1G10.48012869
68PRKACA0.47298629
69TYRO30.47180818
70LRRK20.46262110
71PRKCA0.45509872
72ADRBK10.44645503
73RPS6KA50.43355396
74KDR0.41323511
75CAMK1G0.40965304
76CSNK1E0.40755132
77CAMKK20.40534319
78OBSCN0.40017375
79CSNK2A20.39393198
80MAP3K90.38230675
81EPHB20.37792029
82DYRK1B0.37410009
83CSNK1G20.37038492
84SGK30.36962433
85ERBB20.35348701
86PBK0.34396086
87CAMK2A0.34373062
88PRKG10.33150884
89PNCK0.33036179
90AKT10.32590998
91SGK10.32289223
92PRKCD0.30915416
93PAK10.29862639
94PRKAA20.29596830
95MATK0.28932974
96LCK0.27943174
97STK380.27528881
98PRKAA10.27461378
99AURKA0.27346469
100RPS6KA30.26969349

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.83995370
2Ribosome_Homo sapiens_hsa030103.88091576
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.83701264
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55690808
5Nicotine addiction_Homo sapiens_hsa050332.36080031
6Drug metabolism - other enzymes_Homo sapiens_hsa009832.24973571
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.19967049
8Butanoate metabolism_Homo sapiens_hsa006502.16906414
9Oxidative phosphorylation_Homo sapiens_hsa001902.11846166
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06495660
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05246203
12Phototransduction_Homo sapiens_hsa047441.92572574
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91097346
14Parkinsons disease_Homo sapiens_hsa050121.86151227
15Cardiac muscle contraction_Homo sapiens_hsa042601.85402462
16Linoleic acid metabolism_Homo sapiens_hsa005911.75825527
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71606197
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58465658
19Morphine addiction_Homo sapiens_hsa050321.54664596
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.50554338
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.46878184
22Fat digestion and absorption_Homo sapiens_hsa049751.45206921
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44546735
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44543309
25Huntingtons disease_Homo sapiens_hsa050161.40359018
26Olfactory transduction_Homo sapiens_hsa047401.34051467
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33658934
28Glycerolipid metabolism_Homo sapiens_hsa005611.31775359
29Nitrogen metabolism_Homo sapiens_hsa009101.30948126
30Alzheimers disease_Homo sapiens_hsa050101.30713673
31Peroxisome_Homo sapiens_hsa041461.30573638
32GABAergic synapse_Homo sapiens_hsa047271.26836501
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24404604
34ABC transporters_Homo sapiens_hsa020101.14942176
35Retinol metabolism_Homo sapiens_hsa008301.13003430
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12601939
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12164573
38Chemical carcinogenesis_Homo sapiens_hsa052041.11729261
39Dopaminergic synapse_Homo sapiens_hsa047281.10786532
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10071900
41Caffeine metabolism_Homo sapiens_hsa002321.09423351
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07903759
43Taste transduction_Homo sapiens_hsa047421.05550224
44Pentose phosphate pathway_Homo sapiens_hsa000301.05205011
45Insulin secretion_Homo sapiens_hsa049111.02459086
46Steroid biosynthesis_Homo sapiens_hsa001001.00461080
47beta-Alanine metabolism_Homo sapiens_hsa004100.99767305
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.99441281
49Tryptophan metabolism_Homo sapiens_hsa003800.97744115
50Serotonergic synapse_Homo sapiens_hsa047260.96582800
51Axon guidance_Homo sapiens_hsa043600.95386899
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.93741838
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91349913
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88311638
55Pyrimidine metabolism_Homo sapiens_hsa002400.87356332
56Cholinergic synapse_Homo sapiens_hsa047250.85885825
57Glutamatergic synapse_Homo sapiens_hsa047240.83744934
58Fatty acid degradation_Homo sapiens_hsa000710.82788952
59Sulfur metabolism_Homo sapiens_hsa009200.82108952
60Primary immunodeficiency_Homo sapiens_hsa053400.77024345
61Alcoholism_Homo sapiens_hsa050340.76161995
62Hematopoietic cell lineage_Homo sapiens_hsa046400.75278015
63Arginine and proline metabolism_Homo sapiens_hsa003300.74746913
64Hedgehog signaling pathway_Homo sapiens_hsa043400.72944243
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71992386
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70201682
67Propanoate metabolism_Homo sapiens_hsa006400.69824207
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68562910
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66306793
70RNA polymerase_Homo sapiens_hsa030200.66050579
71Metabolic pathways_Homo sapiens_hsa011000.65197609
72Fatty acid metabolism_Homo sapiens_hsa012120.64925867
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64790093
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64064170
75Circadian entrainment_Homo sapiens_hsa047130.60695670
76Dorso-ventral axis formation_Homo sapiens_hsa043200.60452607
77Cocaine addiction_Homo sapiens_hsa050300.59916274
78Synaptic vesicle cycle_Homo sapiens_hsa047210.57851165
79RNA degradation_Homo sapiens_hsa030180.54686272
80Arachidonic acid metabolism_Homo sapiens_hsa005900.54419509
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53460588
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53017158
83Basal cell carcinoma_Homo sapiens_hsa052170.51488760
84Basal transcription factors_Homo sapiens_hsa030220.51185922
85Ether lipid metabolism_Homo sapiens_hsa005650.50029482
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48658683
87Amphetamine addiction_Homo sapiens_hsa050310.46455131
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.44890133
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43824951
90Bile secretion_Homo sapiens_hsa049760.40766781
91Ovarian steroidogenesis_Homo sapiens_hsa049130.39432269
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39425163
93Starch and sucrose metabolism_Homo sapiens_hsa005000.36074447
94Fanconi anemia pathway_Homo sapiens_hsa034600.34407617
95Thyroid hormone synthesis_Homo sapiens_hsa049180.31118166
96cAMP signaling pathway_Homo sapiens_hsa040240.28557345
97Calcium signaling pathway_Homo sapiens_hsa040200.28291690
98Gastric acid secretion_Homo sapiens_hsa049710.28027426
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27088089
100PPAR signaling pathway_Homo sapiens_hsa033200.25287428

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