COX8A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.50819321
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.50819321
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.48026763
4* respiratory electron transport chain (GO:0022904)8.00432031
5* electron transport chain (GO:0022900)7.82521901
6chaperone-mediated protein transport (GO:0072321)5.75639068
7viral transcription (GO:0019083)5.53545800
8ATP biosynthetic process (GO:0006754)5.35888306
9translational termination (GO:0006415)5.25271534
10oxidative phosphorylation (GO:0006119)5.11143757
11ribosomal small subunit biogenesis (GO:0042274)5.08577714
12* hydrogen ion transmembrane transport (GO:1902600)5.07816363
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.96230027
14purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.93426185
15purine nucleoside triphosphate biosynthetic process (GO:0009145)4.84300397
16cotranslational protein targeting to membrane (GO:0006613)4.76919614
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.76880630
18protein complex biogenesis (GO:0070271)4.72400757
19protein targeting to ER (GO:0045047)4.72149977
20inner mitochondrial membrane organization (GO:0007007)4.71826216
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60702928
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.60702928
23NADH dehydrogenase complex assembly (GO:0010257)4.60702928
24protein localization to endoplasmic reticulum (GO:0070972)4.51812412
25translational elongation (GO:0006414)4.50695382
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.49422139
27ribonucleoside triphosphate biosynthetic process (GO:0009201)4.41931995
28* proton transport (GO:0015992)4.36914487
29mitochondrial respiratory chain complex assembly (GO:0033108)4.35553189
30* hydrogen transport (GO:0006818)4.30148653
31cellular protein complex disassembly (GO:0043624)4.24682757
32viral life cycle (GO:0019058)4.19324979
33regulation of oxidative phosphorylation (GO:0002082)4.12748977
34DNA deamination (GO:0045006)4.10327053
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.99789648
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97951654
37protein targeting to mitochondrion (GO:0006626)3.91479645
38ribosomal small subunit assembly (GO:0000028)3.89386973
39establishment of protein localization to mitochondrion (GO:0072655)3.88212013
40protein neddylation (GO:0045116)3.82247426
41nucleoside triphosphate biosynthetic process (GO:0009142)3.79522224
42protein localization to mitochondrion (GO:0070585)3.72373986
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69507789
44negative regulation of ligase activity (GO:0051352)3.69507789
45termination of RNA polymerase III transcription (GO:0006386)3.68947773
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.68947773
47mitochondrial transport (GO:0006839)3.64678448
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63092357
49translational initiation (GO:0006413)3.62037697
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58230229
51regulation of mitochondrial translation (GO:0070129)3.54782694
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.54092430
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52464771
54ATP hydrolysis coupled proton transport (GO:0015991)3.52464771
55nuclear-transcribed mRNA catabolic process (GO:0000956)3.51495609
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49740815
57regulation of cellular respiration (GO:0043457)3.47275992
58GTP biosynthetic process (GO:0006183)3.44808761
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44637241
60protein complex disassembly (GO:0043241)3.42422134
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.39762763
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.39762763
63protein maturation by protein folding (GO:0022417)3.38934251
64translation (GO:0006412)3.38726799
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36718913
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36718913
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36718913
68mRNA catabolic process (GO:0006402)3.32499011
69protein targeting to membrane (GO:0006612)3.32492994
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.28877509
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28877509
72macromolecular complex disassembly (GO:0032984)3.28495589
73purine nucleoside monophosphate biosynthetic process (GO:0009127)3.24986035
74purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.24986035
75ribonucleoprotein complex biogenesis (GO:0022613)3.23542326
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21960779
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.21593205
78aerobic respiration (GO:0009060)3.17353728
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15896117
80respiratory chain complex IV assembly (GO:0008535)3.14359398
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.13225919
82intracellular protein transmembrane import (GO:0044743)3.12900542
83establishment of viral latency (GO:0019043)3.12170255
84* generation of precursor metabolites and energy (GO:0006091)3.09361753
85positive regulation of ligase activity (GO:0051351)3.06816446
86neuronal action potential propagation (GO:0019227)3.06570829
87rRNA modification (GO:0000154)3.04360395
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03613323
89RNA catabolic process (GO:0006401)3.01720540
90spliceosomal snRNP assembly (GO:0000387)2.99121137
91UTP biosynthetic process (GO:0006228)2.96538243
92calcium-mediated signaling using intracellular calcium source (GO:0035584)2.94841314
93purine ribonucleoside biosynthetic process (GO:0046129)2.90281613
94purine nucleoside biosynthetic process (GO:0042451)2.90281613
95guanosine-containing compound biosynthetic process (GO:1901070)2.89049383
96cytochrome complex assembly (GO:0017004)2.88791035
97establishment of integrated proviral latency (GO:0075713)2.88743919
98ribosomal large subunit biogenesis (GO:0042273)2.88516818
99maturation of SSU-rRNA (GO:0030490)2.88057914
100sequestering of actin monomers (GO:0042989)2.84333901
101negative regulation of microtubule polymerization (GO:0031115)2.83474922
102UTP metabolic process (GO:0046051)2.83052572
103NADH metabolic process (GO:0006734)2.82522126
104detection of temperature stimulus (GO:0016048)2.77226209
105mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.75479301
106protein targeting (GO:0006605)2.73193643
107establishment of protein localization to membrane (GO:0090150)2.70962709
108ribonucleoside monophosphate biosynthetic process (GO:0009156)2.69898105
109removal of superoxide radicals (GO:0019430)2.69594109
110cellular response to superoxide (GO:0071451)2.69594109
111cellular response to oxygen radical (GO:0071450)2.69594109
112synaptic vesicle exocytosis (GO:0016079)2.68290660
113deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.67294316
114GDP-mannose metabolic process (GO:0019673)2.66760829
115tricarboxylic acid cycle (GO:0006099)2.60061607
116nucleoside monophosphate biosynthetic process (GO:0009124)2.58263271
117proteasome assembly (GO:0043248)2.55012088
118regulation of cellular amino acid metabolic process (GO:0006521)2.53146679
119nucleobase-containing small molecule interconversion (GO:0015949)2.52351274
120CTP metabolic process (GO:0046036)2.51905426
121CTP biosynthetic process (GO:0006241)2.51905426
122cellular component biogenesis (GO:0044085)2.50580453
123ribonucleoside biosynthetic process (GO:0042455)2.49970809
124aldehyde catabolic process (GO:0046185)2.48678354
125heme biosynthetic process (GO:0006783)2.47531446
126deoxyribose phosphate biosynthetic process (GO:0046385)2.47521492
1272-deoxyribonucleotide biosynthetic process (GO:0009265)2.47521492
128regulation of protein kinase A signaling (GO:0010738)2.47282977
129mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.0517674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.83573407
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85641887
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.68459172
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.59768244
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32718673
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.24577529
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18078213
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.14423378
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02006817
10* MYC_18555785_ChIP-Seq_MESCs_Mouse2.96895898
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.94010611
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93912434
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80091921
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73584103
15EZH2_22144423_ChIP-Seq_EOC_Human2.62104115
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47963070
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45988765
18* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.40294488
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23194857
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20367137
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14534129
22SRY_22984422_ChIP-ChIP_TESTIS_Rat2.11864308
23XRN2_22483619_ChIP-Seq_HELA_Human2.05708845
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01888636
25CTCF_18555785_ChIP-Seq_MESCs_Mouse2.01050706
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00112610
27* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99890868
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.98636144
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89993609
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85514786
31DCP1A_22483619_ChIP-Seq_HELA_Human1.84349354
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81186131
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80355679
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.72519256
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.66240144
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65026210
37* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64856837
38ZNF263_19887448_ChIP-Seq_K562_Human1.59628466
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58057013
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56612357
41TTF2_22483619_ChIP-Seq_HELA_Human1.52241790
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52122988
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51068416
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48244089
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45565314
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.44723729
47VDR_23849224_ChIP-Seq_CD4+_Human1.39660586
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39573045
49* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38567430
50* ELK1_19687146_ChIP-ChIP_HELA_Human1.38266787
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37651074
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37380986
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36957239
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36115644
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35043541
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34206693
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33301203
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32194855
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31271646
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.30574500
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29878635
62* GABP_19822575_ChIP-Seq_HepG2_Human1.29463257
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.28746150
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28265725
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28205025
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26950478
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25660728
68* KDM5A_27292631_Chip-Seq_BREAST_Human1.25213772
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25121778
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.24943924
71REST_21632747_ChIP-Seq_MESCs_Mouse1.24111889
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22727418
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19552081
74FOXP1_21924763_ChIP-Seq_HESCs_Human1.18983042
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18909977
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17620291
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17484237
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17274252
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16405207
80* FOXM1_23109430_ChIP-Seq_U2OS_Human1.15221208
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14863442
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12907251
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12193916
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11727518
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11571930
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10515558
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10485783
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.10387002
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10135892
90RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09621409
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09621409
92LXR_22292898_ChIP-Seq_THP-1_Human1.08951239
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08751417
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.08507319
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08251944
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07065150
97MYC_18940864_ChIP-ChIP_HL60_Human1.06436647
98RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05447744
99E2F7_22180533_ChIP-Seq_HELA_Human1.05054843
100CTCF_20526341_ChIP-Seq_ESCs_Human1.03991750
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.03845600
102MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03092091
103* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02941321
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01878147
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.00943687
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00799510
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00552303
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00203919
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.99493058
110SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99457868
111SA1_27219007_Chip-Seq_Bcells_Human0.98306648
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98200620
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98033470
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97878326
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97657349
116NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95773864
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95557967
118BCL6_27268052_Chip-Seq_Bcells_Human0.95369623
119* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94691546
120* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93442656
121CTCF_26484167_Chip-Seq_Bcells_Mouse0.93150570
122ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92468859
123* P68_20966046_ChIP-Seq_HELA_Human0.92316996
124FOXP3_21729870_ChIP-Seq_TREG_Human0.92278240
125STAT1_20625510_ChIP-Seq_HELA_Human0.92273641
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91579026
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91513407
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91497489
129VDR_21846776_ChIP-Seq_THP-1_Human0.90901051
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90415416
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88635608
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85277141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.99187569
2MP0003880_abnormal_central_pattern3.81991884
3MP0002736_abnormal_nociception_after3.40234330
4MP0004859_abnormal_synaptic_plasticity3.35980276
5MP0001968_abnormal_touch/_nociception3.25334514
6MP0000372_irregular_coat_pigmentation3.11586430
7MP0010030_abnormal_orbit_morphology3.06023444
8MP0006036_abnormal_mitochondrial_physio2.83444102
9MP0001529_abnormal_vocalization2.73890259
10MP0002733_abnormal_thermal_nociception2.61172335
11MP0004270_analgesia2.53722928
12MP0002735_abnormal_chemical_nociception2.49408878
13MP0002837_dystrophic_cardiac_calcinosis2.49260934
14MP0004145_abnormal_muscle_electrophysio2.43493369
15MP0001970_abnormal_pain_threshold2.40356344
16MP0003635_abnormal_synaptic_transmissio2.31456400
17MP0000749_muscle_degeneration2.28099492
18MP0004043_abnormal_pH_regulation2.25825612
19MP0006276_abnormal_autonomic_nervous2.25014196
20MP0009745_abnormal_behavioral_response2.24771028
21MP0002064_seizures2.18867861
22MP0010386_abnormal_urinary_bladder2.13621533
23MP0003186_abnormal_redox_activity2.07002445
24MP0002734_abnormal_mechanical_nocicepti2.06382640
25MP0000750_abnormal_muscle_regeneration2.05068325
26MP0002938_white_spotting1.96736927
27MP0003123_paternal_imprinting1.95005587
28MP0001905_abnormal_dopamine_level1.94762291
29MP0002272_abnormal_nervous_system1.94192999
30MP0003329_amyloid_beta_deposits1.91812651
31MP0002653_abnormal_ependyma_morphology1.89887781
32MP0001440_abnormal_grooming_behavior1.88299835
33MP0002822_catalepsy1.86615417
34MP0004957_abnormal_blastocyst_morpholog1.85767514
35MP0006035_abnormal_mitochondrial_morpho1.84369868
36MP0005360_urolithiasis1.83042890
37MP0005636_abnormal_mineral_homeostasis1.79944804
38MP0002572_abnormal_emotion/affect_behav1.76628537
39MP0003693_abnormal_embryo_hatching1.73333014
40MP0005451_abnormal_body_composition1.73135617
41MP0004142_abnormal_muscle_tone1.70281133
42MP0005408_hypopigmentation1.67273782
43MP0002063_abnormal_learning/memory/cond1.66605827
44MP0009046_muscle_twitch1.63379469
45MP0003879_abnormal_hair_cell1.61618103
46MP0005332_abnormal_amino_acid1.61145804
47MP0008932_abnormal_embryonic_tissue1.57438119
48MP0006292_abnormal_olfactory_placode1.56610147
49MP0005535_abnormal_body_temperature1.55963303
50MP0005084_abnormal_gallbladder_morpholo1.55661082
51MP0003315_abnormal_perineum_morphology1.54218995
52MP0002638_abnormal_pupillary_reflex1.51035218
53MP0001501_abnormal_sleep_pattern1.49645980
54MP0002277_abnormal_respiratory_mucosa1.46846581
55MP0002163_abnormal_gland_morphology1.44776179
56MP0008872_abnormal_physiological_respon1.42860680
57MP0001984_abnormal_olfaction1.40458279
58MP0002067_abnormal_sensory_capabilities1.37579626
59MP0008058_abnormal_DNA_repair1.36759638
60MP0005645_abnormal_hypothalamus_physiol1.36148142
61MP0003718_maternal_effect1.35023805
62MP0009840_abnormal_foam_cell1.34716275
63MP0001486_abnormal_startle_reflex1.34347142
64MP0004858_abnormal_nervous_system1.34044238
65MP0003806_abnormal_nucleotide_metabolis1.33582228
66MP0003786_premature_aging1.33177510
67MP0005083_abnormal_biliary_tract1.32390354
68MP0001346_abnormal_lacrimal_gland1.28285338
69MP0002909_abnormal_adrenal_gland1.25875747
70MP0003195_calcinosis1.25235626
71MP0001765_abnormal_ion_homeostasis1.22721068
72MP0005058_abnormal_lysosome_morphology1.22363378
73MP0002184_abnormal_innervation1.22355448
74MP0004147_increased_porphyrin_level1.21829907
75MP0005386_behavior/neurological_phenoty1.21322578
76MP0004924_abnormal_behavior1.21322578
77MP0005171_absent_coat_pigmentation1.20901901
78MP0005670_abnormal_white_adipose1.18285064
79MP0008789_abnormal_olfactory_epithelium1.17938709
80MP0005423_abnormal_somatic_nervous1.17044303
81MP0003077_abnormal_cell_cycle1.15921672
82MP0001756_abnormal_urination1.15388809
83MP0000747_muscle_weakness1.14518178
84MP0006072_abnormal_retinal_apoptosis1.11403813
85MP0001485_abnormal_pinna_reflex1.09820923
86MP0009643_abnormal_urine_homeostasis1.09387932
87MP0001502_abnormal_circadian_rhythm1.08260763
88MP0005379_endocrine/exocrine_gland_phen1.07429610
89MP0004215_abnormal_myocardial_fiber1.06041487
90MP0002234_abnormal_pharynx_morphology1.05803262
91MP0003646_muscle_fatigue1.05732762
92MP0005584_abnormal_enzyme/coenzyme_acti1.04570402
93MP0001664_abnormal_digestion1.04253017
94MP0001727_abnormal_embryo_implantation1.04003727
95MP0000537_abnormal_urethra_morphology1.03646290
96MP0008995_early_reproductive_senescence1.03407409
97MP0002095_abnormal_skin_pigmentation1.03061148
98MP0000751_myopathy1.01824876
99MP0002876_abnormal_thyroid_physiology1.01741413
100MP0002066_abnormal_motor_capabilities/c1.00848027
101MP0002557_abnormal_social/conspecific_i0.99065700
102MP0003111_abnormal_nucleus_morphology0.98652787
103MP0001986_abnormal_taste_sensitivity0.98244927
104MP0000955_abnormal_spinal_cord0.96693343
105MP0000343_altered_response_to0.96571094
106MP0004019_abnormal_vitamin_homeostasis0.93288767
107MP0003137_abnormal_impulse_conducting0.92756257
108MP0000013_abnormal_adipose_tissue0.92502452
109MP0001663_abnormal_digestive_system0.92399839
110MP0002229_neurodegeneration0.92006967
111MP0002090_abnormal_vision0.89876493
112MP0010094_abnormal_chromosome_stability0.89608867
113MP0004811_abnormal_neuron_physiology0.88838449
114MP0008875_abnormal_xenobiotic_pharmacok0.88822675
115MP0002139_abnormal_hepatobiliary_system0.87915200
116MP0005381_digestive/alimentary_phenotyp0.87422474
117MP0000026_abnormal_inner_ear0.84281778
118MP0000230_abnormal_systemic_arterial0.84119264
119MP0005085_abnormal_gallbladder_physiolo0.82415598
120MP0001963_abnormal_hearing_physiology0.80306091
121MP0002882_abnormal_neuron_morphology0.78651757
122MP0005075_abnormal_melanosome_morpholog0.78394589
123MP0003638_abnormal_response/metabolism_0.78020669
124MP0002106_abnormal_muscle_physiology0.77956554
125MP0003938_abnormal_ear_development0.77933038
126MP0000566_synostosis0.76796468
127MP0005266_abnormal_metabolism0.75601179
128MP0000759_abnormal_skeletal_muscle0.74413104
129MP0005394_taste/olfaction_phenotype0.73731973
130MP0005499_abnormal_olfactory_system0.73731973
131MP0005551_abnormal_eye_electrophysiolog0.73513216
132MP0004742_abnormal_vestibular_system0.72761172
133MP0000358_abnormal_cell_content/0.72435519
134MP0002210_abnormal_sex_determination0.71765737
135MP0000604_amyloidosis0.71592928
136MP0002752_abnormal_somatic_nervous0.71100073
137MP0008874_decreased_physiological_sensi0.70982516
138MP0001293_anophthalmia0.70377392
139MP0005165_increased_susceptibility_to0.69518541
140MP0004133_heterotaxia0.68593874
141MP0000631_abnormal_neuroendocrine_gland0.67254816
142MP0003011_delayed_dark_adaptation0.67048850
143MP0003136_yellow_coat_color0.65986320
144MP0005330_cardiomyopathy0.65296036
145MP0003656_abnormal_erythrocyte_physiolo0.65268131
146MP0000538_abnormal_urinary_bladder0.65247667
147MP0001764_abnormal_homeostasis0.65041093
148MP0002332_abnormal_exercise_endurance0.65033769
149MP0001881_abnormal_mammary_gland0.63588547
150MP0002972_abnormal_cardiac_muscle0.62834929
151MP0002269_muscular_atrophy0.61060881
152MP0005369_muscle_phenotype0.60795583
153MP0005319_abnormal_enzyme/_coenzyme0.60676438
154MP0001944_abnormal_pancreas_morphology0.60607014
155MP0004510_myositis0.60597406
156MP0009697_abnormal_copulation0.57635447

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.14401958
2Abnormal mitochondria in muscle tissue (HP:0008316)6.64702355
3Mitochondrial inheritance (HP:0001427)6.22026340
4Acute encephalopathy (HP:0006846)6.20167358
5Progressive macrocephaly (HP:0004481)5.92597537
6Myokymia (HP:0002411)5.76999629
7Increased CSF lactate (HP:0002490)5.34030057
8Hepatocellular necrosis (HP:0001404)5.29865815
9Hepatic necrosis (HP:0002605)4.91672947
10Increased hepatocellular lipid droplets (HP:0006565)4.90604745
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.73130928
12Decreased activity of mitochondrial respiratory chain (HP:0008972)4.73130928
13Lipid accumulation in hepatocytes (HP:0006561)4.58970164
14Increased intramyocellular lipid droplets (HP:0012240)4.58665895
15Abnormality of cells of the erythroid lineage (HP:0012130)4.56573302
16Cerebral edema (HP:0002181)4.48407299
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.37255043
18Increased muscle lipid content (HP:0009058)4.29446236
19Renal Fanconi syndrome (HP:0001994)4.20655950
20Abnormal number of erythroid precursors (HP:0012131)3.90929613
21Lactic acidosis (HP:0003128)3.90431572
22Respiratory failure (HP:0002878)3.88796075
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.77229457
24Exercise intolerance (HP:0003546)3.73361890
253-Methylglutaconic aciduria (HP:0003535)3.61352571
26Optic disc pallor (HP:0000543)3.61131296
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.59473058
28Leukodystrophy (HP:0002415)3.38711983
29Exertional dyspnea (HP:0002875)3.36427075
30Hyperphosphaturia (HP:0003109)3.35025825
31Increased serum lactate (HP:0002151)3.32484400
32Abnormality of renal resorption (HP:0011038)3.05130117
33Macrocytic anemia (HP:0001972)2.97972285
34Pheochromocytoma (HP:0002666)2.96447945
35Neuroendocrine neoplasm (HP:0100634)2.93681331
36Glycosuria (HP:0003076)2.90691018
37Abnormality of urine glucose concentration (HP:0011016)2.90691018
38Respiratory difficulties (HP:0002880)2.86254029
39Abnormality of glycolysis (HP:0004366)2.76582838
40Increased serum pyruvate (HP:0003542)2.76582838
41Abnormal urine phosphate concentration (HP:0012599)2.76527676
42Lethargy (HP:0001254)2.73037110
43Emotional lability (HP:0000712)2.61222897
44Type I transferrin isoform profile (HP:0003642)2.53290461
45CNS demyelination (HP:0007305)2.49175865
46X-linked dominant inheritance (HP:0001423)2.47541679
47Reticulocytopenia (HP:0001896)2.44564821
48Myotonia (HP:0002486)2.43418179
49Sensory axonal neuropathy (HP:0003390)2.39604116
50Abnormality of magnesium homeostasis (HP:0004921)2.37617481
51Pallor (HP:0000980)2.35859168
52Microvesicular hepatic steatosis (HP:0001414)2.34247561
53Visual hallucinations (HP:0002367)2.29259479
54Myopathic facies (HP:0002058)2.28303300
55Vomiting (HP:0002013)2.28290464
56Rhabdomyolysis (HP:0003201)2.28010208
57Focal motor seizures (HP:0011153)2.26409613
58Myoglobinuria (HP:0002913)2.22408026
59Aplastic anemia (HP:0001915)2.16618554
60Muscle fiber inclusion bodies (HP:0100299)2.15778307
61Delusions (HP:0000746)2.15087593
62Degeneration of anterior horn cells (HP:0002398)2.14257132
63Abnormality of the anterior horn cell (HP:0006802)2.14257132
64Hyperactive renin-angiotensin system (HP:0000841)2.09227818
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08742982
66Anxiety (HP:0000739)2.07410571
67Metabolic alkalosis (HP:0200114)2.07402528
68Nemaline bodies (HP:0003798)2.07074686
69Renal tubular dysfunction (HP:0000124)2.03409858
70Generalized aminoaciduria (HP:0002909)2.03132142
71Abnormal gallbladder physiology (HP:0012438)2.02893621
72Cholecystitis (HP:0001082)2.02893621
73Ragged-red muscle fibers (HP:0003200)2.01860098
74Testicular atrophy (HP:0000029)1.99210488
75Dicarboxylic aciduria (HP:0003215)1.99150640
76Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99150640
77Abnormal hemoglobin (HP:0011902)1.95477898
78Increased circulating renin level (HP:0000848)1.94751480
79Ketoacidosis (HP:0001993)1.94665882
80Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94612350
81Hypokalemic alkalosis (HP:0001949)1.94077147
82Hypomagnesemia (HP:0002917)1.93908280
83Exercise-induced muscle cramps (HP:0003710)1.93269779
84Abnormality of reticulocytes (HP:0004312)1.90718194
85Congenital, generalized hypertrichosis (HP:0004540)1.88141157
86Reduced antithrombin III activity (HP:0001976)1.88095758
87Abnormal protein glycosylation (HP:0012346)1.87515636
88Abnormal glycosylation (HP:0012345)1.87515636
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87515636
90Abnormal protein N-linked glycosylation (HP:0012347)1.87515636
91Nausea (HP:0002018)1.86776333
92Abnormality of placental membranes (HP:0011409)1.86528098
93Amniotic constriction ring (HP:0009775)1.86528098
94Conjunctival hamartoma (HP:0100780)1.86284046
95Oral leukoplakia (HP:0002745)1.82548079
96Pancytopenia (HP:0001876)1.81733263
97Rough bone trabeculation (HP:0100670)1.79703869
98Neoplasm of the peripheral nervous system (HP:0100007)1.75720249
99Muscle hypertrophy of the lower extremities (HP:0008968)1.73773768
100Retinal dysplasia (HP:0007973)1.73557513
101Cerebral hemorrhage (HP:0001342)1.72940722
102Muscle stiffness (HP:0003552)1.72699025
103Absence seizures (HP:0002121)1.68890927
104Athetosis (HP:0002305)1.68750528
105Hypokinesia (HP:0002375)1.68219928
106Hyperglycinuria (HP:0003108)1.68211358
107Gliosis (HP:0002171)1.68090928
108Microretrognathia (HP:0000308)1.67610528
109Methylmalonic aciduria (HP:0012120)1.67523567
110Palpitations (HP:0001962)1.67482942
111Poor suck (HP:0002033)1.66045646
112Calf muscle hypertrophy (HP:0008981)1.65465388
113Opisthotonus (HP:0002179)1.64980904
114Hyperaldosteronism (HP:0000859)1.64691210
115Sparse eyelashes (HP:0000653)1.64592010
116Concave nail (HP:0001598)1.64204058
117Gout (HP:0001997)1.64099329
118Partial duplication of thumb phalanx (HP:0009944)1.63992481
119Renal salt wasting (HP:0000127)1.63173155
120Alkalosis (HP:0001948)1.62433143
121Atonic seizures (HP:0010819)1.61076472
122Prolonged neonatal jaundice (HP:0006579)1.60945408
123Blindness (HP:0000618)1.59057662
124Partial duplication of the phalanx of hand (HP:0009999)1.57728597
125Late onset (HP:0003584)1.57049060
126Abnormality of secondary sexual hair (HP:0009888)1.56709136
127Abnormality of the axillary hair (HP:0100134)1.56709136
128Delayed CNS myelination (HP:0002188)1.56061390
129Cerebral hypomyelination (HP:0006808)1.55239516
130Muscle fiber atrophy (HP:0100295)1.55194486
131Abnormality of fatty-acid metabolism (HP:0004359)1.55076047
132Distal lower limb muscle weakness (HP:0009053)1.54818563
133Respiratory insufficiency due to muscle weakness (HP:0002747)1.54578206
134Sudden death (HP:0001699)1.54104996
135Ketosis (HP:0001946)1.53300617
136Progressive muscle weakness (HP:0003323)1.53237911
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.50142131
138Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.48840218
139Craniofacial dystonia (HP:0012179)1.47920006
140Adrenal overactivity (HP:0002717)1.47611847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.22495374
2ARAF4.78704596
3NME24.26435055
4MAP3K123.36571648
5GRK53.19590620
6NME12.96547465
7PIM22.53482727
8STK162.16946378
9TESK22.06384065
10EPHA42.06377257
11WNK42.00928982
12CDK191.99720973
13MYLK1.98158073
14MAP3K91.96115757
15KSR21.92375155
16BRAF1.85474762
17ZAK1.82724490
18NTRK31.82251214
19LIMK11.80936743
20BCKDK1.80746596
21OXSR11.68045638
22OBSCN1.65202012
23MAP3K111.56348402
24IRAK31.53469907
25MINK11.53308450
26TESK11.51196261
27PHKG11.49084496
28PHKG21.49084496
29RAF11.46057221
30DAPK31.45492364
31RIPK41.44791737
32DAPK11.44010501
33MUSK1.41442843
34ABL21.41164030
35MST41.34404202
36GRK61.33846724
37STK391.32025296
38PDK21.31795471
39VRK11.30770240
40EPHB21.29375091
41WNK31.29168667
42CDC71.28969331
43LMTK21.20711706
44DAPK21.18628472
45CCNB11.17628204
46UHMK11.16849928
47NTRK11.13016019
48SRPK11.09988801
49ADRBK21.09877701
50ADRBK11.09145557
51SCYL21.07286841
52ILK1.06515312
53EPHA20.98790223
54MAP3K20.96643615
55AURKB0.95692826
56LRRK20.94675142
57TAF10.93441301
58CDK80.93089799
59RPS6KA50.91526455
60GRK70.89111872
61TLK10.88944697
62BUB10.88711884
63CDK140.87083793
64SMG10.85950762
65CAMK2B0.83555335
66WEE10.83348132
67NEK10.83315104
68TAOK20.82071190
69PAK60.80770736
70KDR0.78433027
71CAMK2G0.75632303
72CDK50.75483050
73CDK11A0.74496574
74PRKCG0.73891418
75CDK150.72186839
76PAK10.71769891
77BRSK10.71321229
78MAP2K70.70413546
79AURKA0.70191340
80CDK180.69639765
81DYRK30.68738398
82TNIK0.68650955
83PTK2B0.68529534
84CSNK2A20.67596217
85TAOK10.66873048
86CAMK2D0.66832027
87PLK10.66511999
88CAMK2A0.66483558
89PRKCI0.65995980
90PNCK0.65735392
91PINK10.65005428
92EIF2AK10.64750496
93MAPK130.64436547
94MAP2K40.64359498
95MST1R0.64327145
96MAP2K10.63681567
97MAP2K20.63291397
98TTK0.62500412
99MOS0.61778699
100MAPKAPK50.61773531
101MAP4K20.61459944
102PBK0.60544141
103STK40.60266016
104CHEK20.59943156
105CSNK2A10.57855662
106FGR0.55835265
107AKT20.55105893
108CAMKK20.54710829
109CAMK10.51883864
110TRIB30.50706225
111PRKACA0.50667753
112PLK30.50083199
113MAPKAPK30.50074912
114BMPR20.49835144
115PLK20.49720464
116EIF2AK30.48360681
117CSNK1G20.47509780
118MAP3K10.47292557
119ROCK20.45527281
120CSNK1G10.45498567
121LATS20.45081173
122MAP3K80.44759332
123MAP3K40.43897039
124CSNK1G30.41106945
125PAK40.40698270
126CDK70.39217686
127CSNK1A1L0.38681906
128TNK20.38101161
129IRAK20.37784570
130PRKG20.35098774
131MAPK150.33988707
132MAPK40.33684466
133CASK0.33576279
134TTN0.33522932
135MARK10.33382140
136DYRK20.33208629
137SIK10.32713747
138PRKCA0.32659752
139MARK30.29446436
140RPS6KB20.28972364
141INSRR0.27235704
142CSNK1A10.25347059
143ATR0.23248412
144DYRK1B0.21503511
145PASK0.21477529

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.69936155
2Parkinsons disease_Homo sapiens_hsa050125.78565151
3Alzheimers disease_Homo sapiens_hsa050104.43468892
4Ribosome_Homo sapiens_hsa030104.41698528
5Huntingtons disease_Homo sapiens_hsa050164.00877563
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.66440561
7* Cardiac muscle contraction_Homo sapiens_hsa042603.06982085
8Proteasome_Homo sapiens_hsa030502.47605305
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.19056714
10Collecting duct acid secretion_Homo sapiens_hsa049662.03281174
11Mismatch repair_Homo sapiens_hsa034301.77930362
12Synaptic vesicle cycle_Homo sapiens_hsa047211.72543182
13Protein export_Homo sapiens_hsa030601.71882626
14Base excision repair_Homo sapiens_hsa034101.54341435
15Pyruvate metabolism_Homo sapiens_hsa006201.45666140
16Sulfur metabolism_Homo sapiens_hsa009201.43988662
17Sulfur relay system_Homo sapiens_hsa041221.40902936
18RNA polymerase_Homo sapiens_hsa030201.38216456
19Homologous recombination_Homo sapiens_hsa034401.36435506
20Vibrio cholerae infection_Homo sapiens_hsa051101.29668523
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21462066
22Nucleotide excision repair_Homo sapiens_hsa034201.17949924
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16810436
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14772847
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10341498
26Carbon metabolism_Homo sapiens_hsa012001.09958402
27Propanoate metabolism_Homo sapiens_hsa006401.03351585
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03230328
29Pyrimidine metabolism_Homo sapiens_hsa002401.02849523
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00087137
31Nicotine addiction_Homo sapiens_hsa050330.99584306
32Fatty acid elongation_Homo sapiens_hsa000620.96417917
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96164243
34Folate biosynthesis_Homo sapiens_hsa007900.95328857
35Glutathione metabolism_Homo sapiens_hsa004800.94778353
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88989937
37* Metabolic pathways_Homo sapiens_hsa011000.88138331
38Butanoate metabolism_Homo sapiens_hsa006500.86115250
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85953129
40Systemic lupus erythematosus_Homo sapiens_hsa053220.84717604
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83192784
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80672803
43GABAergic synapse_Homo sapiens_hsa047270.80188684
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77652870
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.77356424
46One carbon pool by folate_Homo sapiens_hsa006700.73683561
47Long-term potentiation_Homo sapiens_hsa047200.66084166
48Taste transduction_Homo sapiens_hsa047420.65550559
49Circadian entrainment_Homo sapiens_hsa047130.65272474
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63828533
51Peroxisome_Homo sapiens_hsa041460.63704849
52Salivary secretion_Homo sapiens_hsa049700.63653553
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63372829
54Pentose phosphate pathway_Homo sapiens_hsa000300.62175119
55Fructose and mannose metabolism_Homo sapiens_hsa000510.61538463
56Glutamatergic synapse_Homo sapiens_hsa047240.60001214
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59851342
58Phenylalanine metabolism_Homo sapiens_hsa003600.58380548
59Arginine biosynthesis_Homo sapiens_hsa002200.58081345
60Biosynthesis of amino acids_Homo sapiens_hsa012300.57730464
61Fatty acid degradation_Homo sapiens_hsa000710.56229190
62RNA transport_Homo sapiens_hsa030130.56137417
63Olfactory transduction_Homo sapiens_hsa047400.54812524
64Serotonergic synapse_Homo sapiens_hsa047260.54499751
65N-Glycan biosynthesis_Homo sapiens_hsa005100.53468843
66Morphine addiction_Homo sapiens_hsa050320.52933172
67RNA degradation_Homo sapiens_hsa030180.52438978
68Gastric acid secretion_Homo sapiens_hsa049710.51802444
69Purine metabolism_Homo sapiens_hsa002300.51315125
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51045987
71Steroid biosynthesis_Homo sapiens_hsa001000.50897444
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49082797
73Fanconi anemia pathway_Homo sapiens_hsa034600.48886087
74Tyrosine metabolism_Homo sapiens_hsa003500.48536356
75Arginine and proline metabolism_Homo sapiens_hsa003300.48187867
76Vitamin B6 metabolism_Homo sapiens_hsa007500.47845347
77Insulin secretion_Homo sapiens_hsa049110.46808894
78Amphetamine addiction_Homo sapiens_hsa050310.46224284
79Dopaminergic synapse_Homo sapiens_hsa047280.46027554
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.45974786
81Fatty acid metabolism_Homo sapiens_hsa012120.44820766
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.44552654
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42592054
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42492618
85Tryptophan metabolism_Homo sapiens_hsa003800.39734109
86Basal transcription factors_Homo sapiens_hsa030220.39669658
87Phototransduction_Homo sapiens_hsa047440.39462013
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37302383
89beta-Alanine metabolism_Homo sapiens_hsa004100.36423791
90Galactose metabolism_Homo sapiens_hsa000520.36354271
91Mineral absorption_Homo sapiens_hsa049780.36275070
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.35794806
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31966473
94DNA replication_Homo sapiens_hsa030300.31462275
95Cholinergic synapse_Homo sapiens_hsa047250.30426388
96Histidine metabolism_Homo sapiens_hsa003400.29811404
97PPAR signaling pathway_Homo sapiens_hsa033200.29668831
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29311564
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29179939
100Fat digestion and absorption_Homo sapiens_hsa049750.27390708
101Renin secretion_Homo sapiens_hsa049240.26982098
102Calcium signaling pathway_Homo sapiens_hsa040200.26929234
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.26745634
104Rheumatoid arthritis_Homo sapiens_hsa053230.26595129
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25504913
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24817489
107Pancreatic secretion_Homo sapiens_hsa049720.24514794
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23315892
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23022433
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22824543
111Alcoholism_Homo sapiens_hsa050340.21396617
112Long-term depression_Homo sapiens_hsa047300.20733045
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20089699
114Bile secretion_Homo sapiens_hsa049760.19975403
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19873658
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19218433
117Arachidonic acid metabolism_Homo sapiens_hsa005900.19137149
118Cell cycle_Homo sapiens_hsa041100.18877922
119Epstein-Barr virus infection_Homo sapiens_hsa051690.18694103
120Gap junction_Homo sapiens_hsa045400.17219556
121Chemical carcinogenesis_Homo sapiens_hsa052040.16941814
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16732947
123Spliceosome_Homo sapiens_hsa030400.15440429
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12122340
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10935616
126Vitamin digestion and absorption_Homo sapiens_hsa049770.10371924
127Basal cell carcinoma_Homo sapiens_hsa052170.04323556
128Nitrogen metabolism_Homo sapiens_hsa009100.03528388
129Other glycan degradation_Homo sapiens_hsa005110.03474873
130Oocyte meiosis_Homo sapiens_hsa041140.03193382
131Lysosome_Homo sapiens_hsa041420.01928328
132Starch and sucrose metabolism_Homo sapiens_hsa005000.01306813

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