COX8C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.75021816
2epithelial cilium movement (GO:0003351)9.50451358
3plasma membrane fusion (GO:0045026)9.50044724
4spermatid development (GO:0007286)9.45806423
5male meiosis (GO:0007140)9.16092497
6motile cilium assembly (GO:0044458)9.16086912
7synaptonemal complex organization (GO:0070193)8.91930754
8synaptonemal complex assembly (GO:0007130)8.64735584
9reproduction (GO:0000003)8.36903559
10cilium movement (GO:0003341)8.13902983
11regulation of cilium movement (GO:0003352)8.02928420
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.86159524
13response to pheromone (GO:0019236)7.59583143
14sexual reproduction (GO:0019953)7.29244466
15single fertilization (GO:0007338)7.02302857
16DNA methylation involved in gamete generation (GO:0043046)6.90175780
17sperm capacitation (GO:0048240)6.88307032
18protein targeting to Golgi (GO:0000042)6.87164924
19male meiosis I (GO:0007141)6.61141052
20establishment of protein localization to Golgi (GO:0072600)6.54368642
21rRNA methylation (GO:0031167)6.53112789
22negative regulation of inclusion body assembly (GO:0090084)6.46349375
23spermatogenesis (GO:0007283)6.32600700
24retrograde transport, vesicle recycling within Golgi (GO:0000301)6.31295865
25male gamete generation (GO:0048232)6.30350944
26fertilization (GO:0009566)6.28403695
27chromosome organization involved in meiosis (GO:0070192)5.98266499
28gamete generation (GO:0007276)5.79027710
29rRNA modification (GO:0000154)5.67578192
30meiotic nuclear division (GO:0007126)5.65491294
31organic cation transport (GO:0015695)5.58612048
32germ cell development (GO:0007281)5.57127279
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.49245400
34meiosis I (GO:0007127)5.37062096
35regulation of inclusion body assembly (GO:0090083)5.30395752
36ventricular system development (GO:0021591)5.29068419
37seminiferous tubule development (GO:0072520)5.22478819
38microtubule depolymerization (GO:0007019)5.22001732
39phosphatidylethanolamine biosynthetic process (GO:0006646)5.11451660
40protein localization to Golgi apparatus (GO:0034067)4.91357788
41calcium ion-dependent exocytosis (GO:0017156)4.84357561
42regulation of microtubule-based movement (GO:0060632)4.80695429
43phosphatidylethanolamine metabolic process (GO:0046337)4.79608982
44meiotic cell cycle (GO:0051321)4.77152248
45cell recognition (GO:0008037)4.66886126
46microtubule severing (GO:0051013)4.64396311
47cerebral cortex neuron differentiation (GO:0021895)4.57387012
48multicellular organismal reproductive process (GO:0048609)4.54071295
49left/right pattern formation (GO:0060972)4.46256129
50RNA destabilization (GO:0050779)4.30147014
51protein localization to cilium (GO:0061512)4.22376589
52chromatin silencing (GO:0006342)4.19202170
53histone H3-K9 demethylation (GO:0033169)4.09000894
54genitalia morphogenesis (GO:0035112)4.08747514
55positive regulation of Rab GTPase activity (GO:0032851)4.06162878
56regulation of Rab GTPase activity (GO:0032313)4.06162878
57DNA packaging (GO:0006323)4.05639269
58chromosome condensation (GO:0030261)4.05309978
59gene silencing by RNA (GO:0031047)4.03437790
60cellular ketone body metabolic process (GO:0046950)3.87846753
61histone exchange (GO:0043486)3.75700282
62protein polyglutamylation (GO:0018095)3.75525886
63spermatid nucleus differentiation (GO:0007289)3.73886887
64glomerular visceral epithelial cell development (GO:0072015)3.72319642
65chaperone-mediated protein complex assembly (GO:0051131)3.72069775
66monoubiquitinated protein deubiquitination (GO:0035520)3.70235955
67meiotic cell cycle process (GO:1903046)3.68431735
68regulation of meiosis I (GO:0060631)3.65908989
69multicellular organismal development (GO:0007275)3.61957730
70musculoskeletal movement (GO:0050881)3.59728570
71multicellular organismal movement (GO:0050879)3.59728570
72microtubule nucleation (GO:0007020)3.53407756
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53318448
74glycerol ether metabolic process (GO:0006662)3.53299206
75negative regulation of organelle assembly (GO:1902116)3.52866197
76glomerular epithelial cell development (GO:0072310)3.52324873
77intraciliary transport (GO:0042073)3.48775813
78axoneme assembly (GO:0035082)3.46464003
79synapsis (GO:0007129)3.43219090
80ketone body metabolic process (GO:1902224)3.39736495
81carnitine transport (GO:0015879)3.38484638
82amino-acid betaine transport (GO:0015838)3.38484638
83carnitine transmembrane transport (GO:1902603)3.34066319
84regulation of spindle checkpoint (GO:0090231)3.28421880
85ether metabolic process (GO:0018904)3.25752725
86left/right axis specification (GO:0070986)3.20772046
87regulation of centriole replication (GO:0046599)3.20674434
88oogenesis (GO:0048477)3.18755806
89nuclear pore complex assembly (GO:0051292)3.16638778
90protein refolding (GO:0042026)3.16166273
91coenzyme catabolic process (GO:0009109)3.16163031
92regulation of transcription involved in cell fate commitment (GO:0060850)3.13118445
93microtubule-based movement (GO:0007018)3.12975644
94DNA synthesis involved in DNA repair (GO:0000731)3.07109444
95positive regulation of meiosis (GO:0045836)3.03974655
96negative regulation of Rho protein signal transduction (GO:0035024)3.03856112
97cellular response to pH (GO:0071467)3.02460670
98resolution of meiotic recombination intermediates (GO:0000712)3.02021049
99female gamete generation (GO:0007292)3.01029403
100gene silencing (GO:0016458)2.99986804
101nucleus organization (GO:0006997)2.97927656
102mitotic sister chromatid cohesion (GO:0007064)2.97075807
103DNA conformation change (GO:0071103)2.93919269
104cilium organization (GO:0044782)2.92168698
105single strand break repair (GO:0000012)2.83815098
106lactate metabolic process (GO:0006089)2.83711996
107sex differentiation (GO:0007548)2.79763950
108cilium morphogenesis (GO:0060271)2.77258810
109sequestering of actin monomers (GO:0042989)2.76599929
110cilium assembly (GO:0042384)2.74502866
111peptidyl-glutamic acid modification (GO:0018200)2.73273637
112DNA alkylation (GO:0006305)2.71848691
113DNA methylation (GO:0006306)2.71848691
114cellular component assembly involved in morphogenesis (GO:0010927)2.70919029
115centriole replication (GO:0007099)2.68416495
116microtubule polymerization or depolymerization (GO:0031109)2.67562410
117interferon-gamma secretion (GO:0072643)2.66062020
118alditol metabolic process (GO:0019400)2.64954517
119nucleoside diphosphate phosphorylation (GO:0006165)2.63790605
120regulation of histone H3-K9 methylation (GO:0051570)2.60752609
121glycolytic process (GO:0006096)2.60385313
122centriole assembly (GO:0098534)2.58903760
123regulation of protein polyubiquitination (GO:1902914)2.58822076
124RNA localization (GO:0006403)2.58200592
125cilium or flagellum-dependent cell motility (GO:0001539)12.9849017
126fusion of sperm to egg plasma membrane (GO:0007342)12.5171793
127sperm motility (GO:0030317)12.3163442
128acrosome reaction (GO:0007340)10.9415435
129sperm-egg recognition (GO:0035036)10.8989512
130piRNA metabolic process (GO:0034587)10.8671898
131acrosome assembly (GO:0001675)10.6148172
132axonemal dynein complex assembly (GO:0070286)10.3260940
133cell wall macromolecule catabolic process (GO:0016998)10.1986854
134cell wall macromolecule metabolic process (GO:0044036)10.1986854
135multicellular organism reproduction (GO:0032504)10.0716821
136binding of sperm to zona pellucida (GO:0007339)10.0242971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07902082
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.56302007
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.09249242
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.11690383
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54985094
6FUS_26573619_Chip-Seq_HEK293_Human2.54969965
7CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.52323428
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42272093
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.39878552
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28006895
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27059667
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.19761811
13UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.19213401
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17366711
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01953897
16ZNF274_21170338_ChIP-Seq_K562_Hela2.00123482
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7468556
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99691772
19VDR_22108803_ChIP-Seq_LS180_Human1.97278129
20ERA_21632823_ChIP-Seq_H3396_Human1.94750831
21ELK4_26923725_Chip-Seq_MESODERM_Mouse1.89678590
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.87110644
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.81356241
24* ER_23166858_ChIP-Seq_MCF-7_Human1.80666439
25RAC3_21632823_ChIP-Seq_H3396_Human1.73092676
26VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.71839177
27SMAD4_21741376_ChIP-Seq_EPCs_Human1.70595812
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68064096
29AR_25329375_ChIP-Seq_VCAP_Human1.67071780
30* P300_19829295_ChIP-Seq_ESCs_Human1.64865413
31TAF15_26573619_Chip-Seq_HEK293_Human1.61646556
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60539433
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57766905
34KLF5_20875108_ChIP-Seq_MESCs_Mouse1.54955390
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54779928
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.54740985
37CBX2_22325352_ChIP-Seq_293T-Rex_Human1.54145536
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53278362
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.52067996
40RBPJ_21746931_ChIP-Seq_IB4_Human1.51767422
41* STAT1_17558387_ChIP-Seq_HELA_Human1.48278373
42KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.47750123
43ETV1_20927104_ChIP-Seq_GIST48_Human1.47373235
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47294245
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.45073673
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44188194
47HNFA_21074721_ChIP-Seq_CACO-2_Human1.43790091
48SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43701168
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42542427
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42009621
51CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.41283299
52GATA3_21867929_ChIP-Seq_CD8_Mouse1.41183483
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41062007
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39959297
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39691977
56* RUNX2_22187159_ChIP-Seq_PCA_Human1.37913803
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36265569
58CBP_20019798_ChIP-Seq_JUKART_Human1.36265569
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.36142980
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.35850729
61FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33352525
62OCT4_20526341_ChIP-Seq_ESCs_Human1.32988239
63TAF2_19829295_ChIP-Seq_ESCs_Human1.32822653
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32389128
65PHF8_20622853_ChIP-Seq_HELA_Human1.31087377
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29658552
67SOX2_19829295_ChIP-Seq_ESCs_Human1.28283890
68NANOG_19829295_ChIP-Seq_ESCs_Human1.28283890
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28122827
70* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27674917
71TBL1_22424771_ChIP-Seq_293T_Human1.26429369
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25944622
73SMAD3_21741376_ChIP-Seq_ESCs_Human1.25216684
74HOXB7_26014856_ChIP-Seq_BT474_Human1.25071088
75LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24807285
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.24797904
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24754364
78PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.24739663
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24678391
80KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23888040
81TP53_18474530_ChIP-ChIP_U2OS_Human1.22980581
82SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.22625293
83P53_21459846_ChIP-Seq_SAOS-2_Human1.22187300
84STAT3_23295773_ChIP-Seq_U87_Human1.22078164
85CEBPB_22108803_ChIP-Seq_LS180_Human1.21771940
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.21373705
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20896826
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20802647
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.18845249
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17182275
91SMAD4_21799915_ChIP-Seq_A2780_Human1.17019773
92KDM2B_26808549_Chip-Seq_REH_Human1.16199337
93REST_21632747_ChIP-Seq_MESCs_Mouse1.15908562
94GATA3_21867929_ChIP-Seq_TH1_Mouse1.13803896
95RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12949127
96* FOXH1_21741376_ChIP-Seq_EPCs_Human1.12943414
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12518321
98BCL6_27268052_Chip-Seq_Bcells_Human1.12299477
99E2F1_17053090_ChIP-ChIP_MCF-7_Human1.12104455
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.11680702
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11680702
102TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.11659214
103GATA6_21074721_ChIP-Seq_CACO-2_Human1.11581243
104NCOR_22424771_ChIP-Seq_293T_Human1.10686369
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10660898
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10440709
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09538545
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09538545
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.09214495
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.08540551
111YY1_22570637_ChIP-Seq_MALME-3M_Human1.07948324
112NFYA_21822215_ChIP-Seq_K562_Human1.06952156
113SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06483484
114E2F1_20622854_ChIP-Seq_HELA_Human1.05574466
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05563183
116GF1_26923725_Chip-Seq_HPCs_Mouse1.05474081
117PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04723407
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04586367
119CTCF_27219007_Chip-Seq_Bcells_Human1.04578240
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04229284
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03788839
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03730452
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03206373
124BCOR_27268052_Chip-Seq_Bcells_Human1.03147302
125P300_27268052_Chip-Seq_Bcells_Human1.02613114
126DROSHA_22980978_ChIP-Seq_HELA_Human1.02144613
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02021557
128ERG_20517297_ChIP-Seq_VCAP_Human1.01042086
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00881101
130SALL4_22934838_ChIP-ChIP_CD34+_Human1.00851791
131RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00705668
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00527943
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.00347015
134SMRT_27268052_Chip-Seq_Bcells_Human1.00316882
135GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00030311
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99582236
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.98016189
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.97593173
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.96906069
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96685161
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96496025
142SOX2_21211035_ChIP-Seq_LN229_Human0.96175887
143MYC_27129775_Chip-Seq_CORNEA_Mouse0.96088089
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.93817151
145SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92104604
146CTCF_20526341_ChIP-Seq_ESCs_Human0.91765689
147LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91428843
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90387504
149CBX2_27304074_Chip-Seq_ESCs_Mouse0.90028236
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.89419630
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89037593
152CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88942959
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88829160
154FLI1_21867929_ChIP-Seq_CD8_Mouse0.88754771
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.88456136
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.86345985
157SOX11_22085726_ChIP-Seq_ESNs_Mouse0.86311031
158NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86203131
159RNF2_27304074_Chip-Seq_NSC_Mouse0.85015921
160OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84977301
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84826463
162EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84708859
163NFYB_21822215_ChIP-Seq_K562_Human0.82778341
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81968221
165NANOG_20526341_ChIP-Seq_ESCs_Human0.81498464
166PHF8_20622854_ChIP-Seq_HELA_Human0.80964187
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.80955737
168MYC_19829295_ChIP-Seq_ESCs_Human0.80301169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02928369
2MP0001929_abnormal_gametogenesis5.64679437
3MP0008877_abnormal_DNA_methylation5.58882700
4MP0002210_abnormal_sex_determination3.94714275
5MP0001145_abnormal_male_reproductive3.34522970
6MP0002161_abnormal_fertility/fecundity3.27287362
7MP0003718_maternal_effect3.16539668
8MP0002653_abnormal_ependyma_morphology2.96477431
9MP0000653_abnormal_sex_gland2.89850086
10MP0001348_abnormal_lacrimal_gland2.85300960
11MP0002160_abnormal_reproductive_system2.34824396
12MP0000678_abnormal_parathyroid_gland2.32709275
13MP0005410_abnormal_fertilization15.2224212
14MP0005670_abnormal_white_adipose1.95472537
15MP0005379_endocrine/exocrine_gland_phen1.93631693
16MP0005623_abnormal_meninges_morphology1.86048731
17MP0003646_muscle_fatigue1.82402923
18MP0008789_abnormal_olfactory_epithelium1.59346358
19MP0001485_abnormal_pinna_reflex1.50762868
20MP0008995_early_reproductive_senescence1.42400237
21MP0005499_abnormal_olfactory_system1.41392124
22MP0005394_taste/olfaction_phenotype1.41392124
23MP0005310_abnormal_salivary_gland1.37502151
24MP0002132_abnormal_respiratory_system1.36103431
25MP0002282_abnormal_trachea_morphology1.35115829
26MP0001486_abnormal_startle_reflex1.33540737
27MP0008057_abnormal_DNA_replication1.33266451
28MP0004233_abnormal_muscle_weight1.31335140
29MP0008058_abnormal_DNA_repair1.27165753
30MP0002249_abnormal_larynx_morphology1.25318953
31MP0005389_reproductive_system_phenotype1.18168473
32MP0005451_abnormal_body_composition1.16534327
33MP0005395_other_phenotype1.15083323
34MP0000681_abnormal_thyroid_gland1.14939762
35MP0010094_abnormal_chromosome_stability1.13518606
36MP0003183_abnormal_peptide_metabolism1.10414560
37MP0006292_abnormal_olfactory_placode1.09422002
38MP0005645_abnormal_hypothalamus_physiol1.08430038
39MP0005647_abnormal_sex_gland1.05124980
40MP0005423_abnormal_somatic_nervous1.04715474
41MP0001963_abnormal_hearing_physiology1.02708556
42MP0000026_abnormal_inner_ear0.98785232
43MP0002127_abnormal_cardiovascular_syste0.98691406
44MP0001968_abnormal_touch/_nociception0.96845291
45MP0003119_abnormal_digestive_system0.96558105
46MP0001984_abnormal_olfaction0.94891195
47MP0003786_premature_aging0.91186082
48MP0000566_synostosis0.90413217
49MP0009046_muscle_twitch0.89360351
50MP0005377_hearing/vestibular/ear_phenot0.87755478
51MP0003878_abnormal_ear_physiology0.87755478
52MP0001765_abnormal_ion_homeostasis0.82615215
53MP0002735_abnormal_chemical_nociception0.79355249
54MP0000049_abnormal_middle_ear0.78636369
55MP0008007_abnormal_cellular_replicative0.73686378
56MP0003115_abnormal_respiratory_system0.73168843
57MP0002229_neurodegeneration0.72301328
58MP0003111_abnormal_nucleus_morphology0.70615979
59MP0004510_myositis0.70517129
60MP0010368_abnormal_lymphatic_system0.70261240
61MP0002067_abnormal_sensory_capabilities0.67611751
62MP0000358_abnormal_cell_content/0.67130111
63MP0009278_abnormal_bone_marrow0.66336834
64MP0003011_delayed_dark_adaptation0.65846543
65MP0000955_abnormal_spinal_cord0.65225994
66MP0005248_abnormal_Harderian_gland0.64940591
67MP0000569_abnormal_digit_pigmentation0.62583548
68MP0003880_abnormal_central_pattern0.62508817
69MP0004085_abnormal_heartbeat0.61376882
70MP0005397_hematopoietic_system_phenotyp0.58598221
71MP0001545_abnormal_hematopoietic_system0.58598221
72MP0003699_abnormal_female_reproductive0.58095951
73MP0002234_abnormal_pharynx_morphology0.57535645
74MP0005167_abnormal_blood-brain_barrier0.57511830
75MP0006276_abnormal_autonomic_nervous0.56856115
76MP0002272_abnormal_nervous_system0.55616918
77MP0005360_urolithiasis0.55366790
78MP0005375_adipose_tissue_phenotype0.55330643
79MP0003137_abnormal_impulse_conducting0.55224356
80MP0002557_abnormal_social/conspecific_i0.54497028
81MP0005084_abnormal_gallbladder_morpholo0.54325172
82MP0002572_abnormal_emotion/affect_behav0.54083685
83MP0003959_abnormal_lean_body0.53635680
84MP0004957_abnormal_blastocyst_morpholog0.52378759
85MP0000631_abnormal_neuroendocrine_gland0.51788287
86MP0001730_embryonic_growth_arrest0.50905136
87MP0009697_abnormal_copulation0.50900959
88MP0003950_abnormal_plasma_membrane0.50831447
89MP0009053_abnormal_anal_canal0.50792671
90MP0001293_anophthalmia0.50340458
91MP0005367_renal/urinary_system_phenotyp0.49723618
92MP0000516_abnormal_urinary_system0.49723618
93MP0002138_abnormal_hepatobiliary_system0.48968944
94MP0003329_amyloid_beta_deposits0.47437627
95MP0001119_abnormal_female_reproductive0.46438593
96MP0004808_abnormal_hematopoietic_stem0.46355011
97MP0010307_abnormal_tumor_latency0.46334801
98MP0002928_abnormal_bile_duct0.44061595
99MP0005666_abnormal_adipose_tissue0.43821434
100MP0006036_abnormal_mitochondrial_physio0.43000209
101MP0001661_extended_life_span0.42900456
102MP0002734_abnormal_mechanical_nocicepti0.41123591
103MP0002269_muscular_atrophy0.40838160
104MP0001879_abnormal_lymphatic_vessel0.40688100
105MP0009745_abnormal_behavioral_response0.40529500
106MP0005332_abnormal_amino_acid0.40199849
107MP0004134_abnormal_chest_morphology0.40115953
108MP0002733_abnormal_thermal_nociception0.39605531
109MP0003693_abnormal_embryo_hatching0.39536071
110MP0001324_abnormal_eye_pigmentation0.39029734
111MP0005636_abnormal_mineral_homeostasis0.38978683
112MP0001666_abnormal_nutrient_absorption0.38702525
113MP0001727_abnormal_embryo_implantation0.38177176
114MP0004036_abnormal_muscle_relaxation0.37921277
115MP0003077_abnormal_cell_cycle0.37532363
116MP0003121_genomic_imprinting0.36350431
117MP0000313_abnormal_cell_death0.33370418
118MP0003879_abnormal_hair_cell0.32026065
119MP0003936_abnormal_reproductive_system0.31379538
120MP0005391_vision/eye_phenotype0.31184531
121MP0002084_abnormal_developmental_patter0.30671766
122MP0005253_abnormal_eye_physiology0.30388310
123MP0000751_myopathy0.30368716
124MP0003861_abnormal_nervous_system0.30051005
125MP0000534_abnormal_ureter_morphology0.28900500
126MP0002971_abnormal_brown_adipose0.28871052
127MP0003045_fibrosis0.28717876
128MP0003942_abnormal_urinary_system0.27996004
129MP0004133_heterotaxia0.26871868
130MP0005551_abnormal_eye_electrophysiolog0.26634054
131MP0001764_abnormal_homeostasis0.26287170
132MP0004811_abnormal_neuron_physiology0.26060818
133MP0008961_abnormal_basal_metabolism0.25775347
134MP0009115_abnormal_fat_cell0.25451355
135MP0001697_abnormal_embryo_size0.25258520
136MP0002092_abnormal_eye_morphology0.24571714
137MP0002152_abnormal_brain_morphology0.24516994
138MP0001672_abnormal_embryogenesis/_devel0.23764973
139MP0005380_embryogenesis_phenotype0.23764973
140MP0003787_abnormal_imprinting0.23294617
141MP0006035_abnormal_mitochondrial_morpho0.23232980
142MP0004197_abnormal_fetal_growth/weight/0.21671464
143MP0000604_amyloidosis0.18851516
144MP0004019_abnormal_vitamin_homeostasis0.17899289
145MP0002080_prenatal_lethality0.17432059
146MP0002108_abnormal_muscle_morphology0.15925806
147MP0003984_embryonic_growth_retardation0.15856698
148MP0002169_no_abnormal_phenotype0.15759526
149MP0002873_normal_phenotype0.15537375
150MP0002102_abnormal_ear_morphology0.15122862
151MP0004043_abnormal_pH_regulation0.15076660
152MP0002085_abnormal_embryonic_tissue0.14954536
153MP0003948_abnormal_gas_homeostasis0.14936485
154MP0009672_abnormal_birth_weight0.14520338
155MP0003631_nervous_system_phenotype0.14132941
156MP0003633_abnormal_nervous_system0.13960018
157MP0002088_abnormal_embryonic_growth/wei0.13406664
158MP0001851_eye_inflammation0.13254028
159MP0004742_abnormal_vestibular_system0.12737701
160MP0000001_mammalian_phenotype0.12661305

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.06356248
2Abnormal respiratory epithelium morphology (HP:0012253)8.68355175
3Abnormal respiratory motile cilium morphology (HP:0005938)8.68355175
4Rhinitis (HP:0012384)8.00537361
5Chronic bronchitis (HP:0004469)7.03387358
6Abnormal ciliary motility (HP:0012262)7.02375459
7Infertility (HP:0000789)6.73380542
8Severe visual impairment (HP:0001141)6.42763068
9Nasal polyposis (HP:0100582)6.40263357
10Abnormality of the nasal mucosa (HP:0000433)5.24469822
11Nephronophthisis (HP:0000090)4.74067588
12Chronic hepatic failure (HP:0100626)4.67897039
13Bronchiectasis (HP:0002110)4.65190768
14Bronchitis (HP:0012387)4.51127872
15Asymmetric septal hypertrophy (HP:0001670)4.35039399
16Bony spicule pigmentary retinopathy (HP:0007737)4.34646016
17Attenuation of retinal blood vessels (HP:0007843)4.15471698
18Resting tremor (HP:0002322)4.07302235
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.94890674
20Male infertility (HP:0003251)3.91358538
21Cone-rod dystrophy (HP:0000548)3.76698213
22Hyperkalemia (HP:0002153)3.76697410
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.69847465
24Abnormality of macular pigmentation (HP:0008002)3.65787451
25Abnormality of the renal medulla (HP:0100957)3.58470737
26Abnormal spermatogenesis (HP:0008669)3.57759277
27Gonadotropin excess (HP:0000837)3.39951142
28Recurrent otitis media (HP:0000403)3.31486538
29Truncal obesity (HP:0001956)3.24083515
30Abnormality of the lower motor neuron (HP:0002366)3.17825351
31Osteomalacia (HP:0002749)3.13576684
32Menstrual irregularities (HP:0000858)2.99556989
33Recurrent sinusitis (HP:0011108)2.97116771
34Tubulointerstitial nephritis (HP:0001970)2.95680847
35Progressive cerebellar ataxia (HP:0002073)2.89993528
36Azoospermia (HP:0000027)2.87843144
37Tubular atrophy (HP:0000092)2.86281271
38Thyroid-stimulating hormone excess (HP:0002925)2.84748104
39Recurrent bronchitis (HP:0002837)2.82954881
40Impulsivity (HP:0100710)2.81128287
41Abnormal rod and cone electroretinograms (HP:0008323)2.77084913
42Potter facies (HP:0002009)2.75610873
43Facial shape deformation (HP:0011334)2.75610873
44Abnormality of midbrain morphology (HP:0002418)2.67967470
45Molar tooth sign on MRI (HP:0002419)2.67967470
46Postural instability (HP:0002172)2.64525311
47Amelogenesis imperfecta (HP:0000705)2.61461749
48Tubulointerstitial abnormality (HP:0001969)2.60996511
49Progressive sensorineural hearing impairment (HP:0000408)2.60450100
50Generalized aminoaciduria (HP:0002909)2.59716452
51Abnormality of dental color (HP:0011073)2.59630892
52Horizontal nystagmus (HP:0000666)2.56787889
53Enlarged epiphyses (HP:0010580)2.52472160
54Hypoalphalipoproteinemia (HP:0003233)2.48815029
55Amyotrophic lateral sclerosis (HP:0007354)2.47257087
56Medial flaring of the eyebrow (HP:0010747)2.46688502
57Renal Fanconi syndrome (HP:0001994)2.44287503
58Scotoma (HP:0000575)2.41288943
59Insulin-resistant diabetes mellitus (HP:0000831)2.40485969
60Portal hypertension (HP:0001409)2.35162037
61Hypoplasia of the thymus (HP:0000778)2.34378193
62Fibular hypoplasia (HP:0003038)2.33810077
63Optic nerve hypoplasia (HP:0000609)2.29102360
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25848794
65Intellectual disability, moderate (HP:0002342)2.21687311
66Oligodactyly (hands) (HP:0001180)2.19155681
67Impaired proprioception (HP:0010831)2.18323647
68Tubulointerstitial fibrosis (HP:0005576)2.16366556
69Abnormality of the hepatic vasculature (HP:0006707)2.14283150
70Postaxial foot polydactyly (HP:0001830)2.12727900
71Stage 5 chronic kidney disease (HP:0003774)2.12709377
72Volvulus (HP:0002580)2.08461031
73Abnormality of the aortic arch (HP:0012303)2.06016545
74Abnormality of potassium homeostasis (HP:0011042)2.05566041
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03772606
76Absent frontal sinuses (HP:0002688)2.03333274
77Spastic tetraparesis (HP:0001285)2.01280871
78Short ribs (HP:0000773)2.00213636
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1730425
80Absent/shortened dynein arms (HP:0200106)12.3895564
81Dynein arm defect of respiratory motile cilia (HP:0012255)12.3895564
82Hypoplastic ischia (HP:0003175)1.99666218
83Polydipsia (HP:0001959)1.97068225
84Abnormal drinking behavior (HP:0030082)1.97068225
85Unilateral renal agenesis (HP:0000122)1.96117356
86Renovascular hypertension (HP:0100817)1.95338861
87Abnormal gallbladder physiology (HP:0012438)1.92960532
88Cholecystitis (HP:0001082)1.92960532
89Abnormality of cochlea (HP:0000375)1.91582919
90Subcapsular cataract (HP:0000523)1.91456831
91Congenital hepatic fibrosis (HP:0002612)1.89212156
92Absent epiphyses (HP:0010577)1.89059485
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89059485
94Congenital malformation of the right heart (HP:0011723)1.88920497
95Double outlet right ventricle (HP:0001719)1.88920497
96Abnormality of the costochondral junction (HP:0000919)1.87243075
97Abnormality of the renal cortex (HP:0011035)1.86183005
98Photophobia (HP:0000613)1.85853978
99Increased purine levels (HP:0004368)1.83747851
100Hyperuricemia (HP:0002149)1.83747851
101Respiratory distress (HP:0002098)1.83639749
102Heterotopia (HP:0002282)1.82884428
103Abnormality of urine glucose concentration (HP:0011016)1.82867440
104Glycosuria (HP:0003076)1.82867440
105Abdominal situs inversus (HP:0003363)1.81488107
106Abnormality of abdominal situs (HP:0011620)1.81488107
107Abnormality of renal resorption (HP:0011038)1.80846194
108Oculomotor apraxia (HP:0000657)1.79206900
109Renal dysplasia (HP:0000110)1.77952469
110Duodenal stenosis (HP:0100867)1.77699750
111Small intestinal stenosis (HP:0012848)1.77699750
112Microglossia (HP:0000171)1.76755280
113Hypochromic microcytic anemia (HP:0004840)1.75110916
114J-shaped sella turcica (HP:0002680)1.74864185
115Abnormality of lateral ventricle (HP:0030047)1.74402416
116Focal segmental glomerulosclerosis (HP:0000097)1.72273204
117Upper motor neuron abnormality (HP:0002127)1.70086077
118Abnormality of dentin (HP:0010299)1.69878247
119Bell-shaped thorax (HP:0001591)1.69449312
120Abnormality of the ischium (HP:0003174)1.69233370
121Hyponatremia (HP:0002902)1.68272949
122Myokymia (HP:0002411)1.67100337
123Upper limb muscle weakness (HP:0003484)1.66471034
124Supernumerary spleens (HP:0009799)1.63691975
125Facial cleft (HP:0002006)1.61539343
126Abnormality of renal excretion (HP:0011036)1.60066287
127Abnormality of the dental root (HP:0006486)1.58930788
128Taurodontia (HP:0000679)1.58930788
129Abnormality of permanent molar morphology (HP:0011071)1.58930788
130Dyschromatopsia (HP:0007641)1.57974521
131Postaxial hand polydactyly (HP:0001162)1.57915096
132Bile duct proliferation (HP:0001408)1.54669466
133Abnormal biliary tract physiology (HP:0012439)1.54669466
134Deformed sella turcica (HP:0002681)1.54208518
135Short thorax (HP:0010306)1.53983486
136Degeneration of anterior horn cells (HP:0002398)1.53853826
137Abnormality of the anterior horn cell (HP:0006802)1.53853826
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53124130
139Chronic sinusitis (HP:0011109)1.50456542
140Choroideremia (HP:0001139)1.49136132
141Abnormality of molar (HP:0011077)1.48352346
142Abnormality of molar morphology (HP:0011070)1.48352346
143Short femoral neck (HP:0100864)1.47015849
144Abnormality of the dental pulp (HP:0006479)1.43822444
145Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.41980855
146Aplasia/Hypoplasia of the fibula (HP:0006492)1.41122327
147Median cleft lip (HP:0000161)1.38715766
148Broad distal phalanx of finger (HP:0009836)1.38411566
149Nephropathy (HP:0000112)1.35793030
150Abnormality of ocular smooth pursuit (HP:0000617)1.35220797
151Abnormal urine output (HP:0012590)1.33386210
152Cystic liver disease (HP:0006706)1.33358441
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.31026324
154Cerebellar dysplasia (HP:0007033)1.30885179
155Decreased central vision (HP:0007663)1.28108085
156Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.24340982
157Aplasia/Hypoplasia of the lens (HP:0008063)1.23481314
158Neurofibrillary tangles (HP:0002185)1.23435932
159Decreased motor nerve conduction velocity (HP:0003431)1.23383322
160Pachygyria (HP:0001302)1.22906929
161Difficulty climbing stairs (HP:0003551)1.22255877
162Congenital primary aphakia (HP:0007707)1.20776235
163Polyuria (HP:0000103)1.20451975
164Hemiparesis (HP:0001269)1.19712496
165Gait imbalance (HP:0002141)1.19633478
166Pancreatic fibrosis (HP:0100732)1.18686263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.10302457
2PDK38.10302457
3INSRR6.49121661
4TESK16.17563721
5PDK25.26251470
6PRKD34.69484098
7ICK4.31790101
8PLK23.90562261
9BRD43.74949774
10MAP4K22.99011228
11PTK2B2.58491308
12WNK42.50774053
13STK392.43772893
14PNCK2.42859113
15CDK192.40464716
16NEK22.10490916
17DDR22.06088695
18PIK3CG1.77054046
19STK381.75740212
20MAP3K91.37786790
21OXSR11.24033486
22DYRK1B1.20969022
23MAPK151.20576031
24WNK11.15385091
25MST1R1.09235793
26KSR21.08916029
27TYRO31.07404152
28CDK71.01599350
29PDK10.93119985
30STK30.91166165
31TIE10.87524684
32CDC70.85738204
33ARAF0.85321618
34CCNB10.84454374
35DYRK30.83794144
36PASK0.82051233
37MET0.79459729
38MAP3K20.78930333
39TTK0.75476566
40WEE10.70035818
41PINK10.68951891
42MAP3K130.66521457
43IRAK10.62666589
44TNIK0.58716777
45CHEK20.58363797
46MAP3K80.57501889
47CAMK1G0.56610927
48CHEK10.56265002
49AKT30.55582322
50ATR0.53242475
51ACVR1B0.52008804
52CDK30.51618799
53EEF2K0.51323022
54LATS20.47157518
55TESK20.46959643
56EPHA40.46668981
57CAMK10.45755223
58PDPK10.45527677
59CDK120.44314035
60MAP2K20.43533153
61SGK10.41275831
62ATM0.40089430
63LMTK20.39036066
64MTOR0.38799699
65TRIM280.38160683
66VRK10.38090637
67STK38L0.38008910
68FRK0.36883825
69PLK40.36818476
70NTRK30.35905211
71PBK0.35537221
72BMPR1B0.34548019
73PAK10.33869920
74BLK0.33006091
75PLK10.30396739
76PRKAA20.30360860
77PAK20.29911218
78ADRBK20.29661142
79IRAK20.28992394
80NTRK20.28890285
81PKN10.28563720
82PRKG20.26718311
83UHMK10.26583675
84MAP3K10.26056583
85NEK60.25346514
86MAP2K60.25290629
87PRKCG0.25178195
88SGK2230.25075913
89SGK4940.25075913
90MUSK0.24620473
91PRKAA10.24147571
92LATS10.23616716
93MOS0.22241574
94RPS6KB10.21669465
95CAMK1D0.20314859
96RIPK40.19640609
97MARK20.19257393
98ROCK10.19156756
99CAMK2A0.18914736
100CAMKK10.18715780
101ZAK0.18330029
102MAPK140.18295724
103NUAK10.17976695
104PAK40.17960995
105MARK10.17240218
106MAP2K70.16701753
107CAMK40.16489585
108PRKACA0.15233329
109AKT10.15089623
110BRSK20.14469306
111RPS6KA20.12993108
112WNK30.12257219
113PRKCE0.11116849
114CDK20.09735761
115MAPKAPK50.09490281
116CDK10.09154155
117PRKCZ0.08270009
118GSK3B0.07522959
119CSNK2A10.07186036
120MAP3K40.06630545
121PAK60.05646072
122RPS6KA10.05247875
123PRKCQ0.05061474
124MAPK80.04544312
125CSNK1D0.04543412
126CSF1R0.04028651
127BRSK10.03717719
128MARK30.03691559
129BRAF0.03630121
130STK110.03472936
131PRKDC0.03167856
132CDK60.02667630
133CDK150.02392436
134PDGFRB0.01840760
135EGFR0.01549700
136BUB10.01491745
137CSNK2A20.01373334
138TAOK10.01338584
139MAP3K100.01281224
140PRKACB0.01096269
141PRKACG0.00839093
142CDK40.00750332
143STK100.00306135
144CDK180.00190976
145EPHB1-0.0323182
146PIM1-0.0304979
147ZAP70-0.0264441
148CSK-0.0262620
149MAPK1-0.0245795
150MAPK10-0.0233310
151CDK14-0.0197714
152RPS6KA3-0.0175308
153AURKA-0.0132149
154PRKG1-0.0080341
155PRKCB-0.0037998
156CDK11A-0.0003892

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.20410809
2Olfactory transduction_Homo sapiens_hsa047404.21116016
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.07544544
4Vitamin B6 metabolism_Homo sapiens_hsa007503.91953145
5Pyruvate metabolism_Homo sapiens_hsa006203.86034200
6Fatty acid biosynthesis_Homo sapiens_hsa000613.72368251
7Basal transcription factors_Homo sapiens_hsa030223.02378525
8Dorso-ventral axis formation_Homo sapiens_hsa043202.97550393
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.93464160
10Propanoate metabolism_Homo sapiens_hsa006402.86669052
11Linoleic acid metabolism_Homo sapiens_hsa005912.81262197
12Selenocompound metabolism_Homo sapiens_hsa004502.75069259
13Glucagon signaling pathway_Homo sapiens_hsa049222.75055617
14Butanoate metabolism_Homo sapiens_hsa006502.74561038
15Fanconi anemia pathway_Homo sapiens_hsa034602.37355895
16Oocyte meiosis_Homo sapiens_hsa041142.08377046
17Pentose phosphate pathway_Homo sapiens_hsa000302.04914438
18Glycerolipid metabolism_Homo sapiens_hsa005612.01797442
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.94146902
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.92840204
21Mismatch repair_Homo sapiens_hsa034301.87058011
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79498823
23mRNA surveillance pathway_Homo sapiens_hsa030151.75961106
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69843074
25Amphetamine addiction_Homo sapiens_hsa050311.64177640
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.63860515
27PPAR signaling pathway_Homo sapiens_hsa033201.59659213
28RNA transport_Homo sapiens_hsa030131.58390233
29Phototransduction_Homo sapiens_hsa047441.54178159
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51665111
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.48513143
32Phenylalanine metabolism_Homo sapiens_hsa003601.45678806
33Fructose and mannose metabolism_Homo sapiens_hsa000511.40217009
34Huntingtons disease_Homo sapiens_hsa050161.39779944
35Fat digestion and absorption_Homo sapiens_hsa049751.37095877
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33326106
37Carbon metabolism_Homo sapiens_hsa012001.31385113
38Ether lipid metabolism_Homo sapiens_hsa005651.30211657
39Type II diabetes mellitus_Homo sapiens_hsa049301.25346836
40Fatty acid metabolism_Homo sapiens_hsa012121.21905924
41Antigen processing and presentation_Homo sapiens_hsa046121.21503874
42Type I diabetes mellitus_Homo sapiens_hsa049401.21143793
43Nucleotide excision repair_Homo sapiens_hsa034201.20890419
44Renin secretion_Homo sapiens_hsa049241.18545000
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13089420
46Base excision repair_Homo sapiens_hsa034101.10251191
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08065198
48Fatty acid degradation_Homo sapiens_hsa000711.05340359
49Allograft rejection_Homo sapiens_hsa053301.00504393
50Autoimmune thyroid disease_Homo sapiens_hsa053201.00057884
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99097076
52Mineral absorption_Homo sapiens_hsa049780.98609630
53Arginine and proline metabolism_Homo sapiens_hsa003300.98130293
54Purine metabolism_Homo sapiens_hsa002300.98124409
55Glutathione metabolism_Homo sapiens_hsa004800.97733112
56Nicotine addiction_Homo sapiens_hsa050330.97026650
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.95383330
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88344774
59Long-term potentiation_Homo sapiens_hsa047200.84614038
60Viral myocarditis_Homo sapiens_hsa054160.82906237
61Graft-versus-host disease_Homo sapiens_hsa053320.81775884
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80787590
63Biosynthesis of amino acids_Homo sapiens_hsa012300.80683146
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.79237344
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78518279
66Hedgehog signaling pathway_Homo sapiens_hsa043400.75804720
67Retinol metabolism_Homo sapiens_hsa008300.75537410
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75053144
69ABC transporters_Homo sapiens_hsa020100.74672570
70Estrogen signaling pathway_Homo sapiens_hsa049150.73655130
71Regulation of autophagy_Homo sapiens_hsa041400.72016387
72Systemic lupus erythematosus_Homo sapiens_hsa053220.68370096
73Arachidonic acid metabolism_Homo sapiens_hsa005900.68340396
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68132025
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.66802283
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.65699274
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63660217
78Circadian rhythm_Homo sapiens_hsa047100.63297812
79Chemical carcinogenesis_Homo sapiens_hsa052040.63045517
80Morphine addiction_Homo sapiens_hsa050320.62785763
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62748739
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62609816
83beta-Alanine metabolism_Homo sapiens_hsa004100.59660624
84Salivary secretion_Homo sapiens_hsa049700.59370362
85Tyrosine metabolism_Homo sapiens_hsa003500.57507891
86Serotonergic synapse_Homo sapiens_hsa047260.56382794
87AMPK signaling pathway_Homo sapiens_hsa041520.54829379
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.53580523
89Legionellosis_Homo sapiens_hsa051340.52841614
90VEGF signaling pathway_Homo sapiens_hsa043700.51302355
91Homologous recombination_Homo sapiens_hsa034400.50831989
92Endocytosis_Homo sapiens_hsa041440.49956316
93Influenza A_Homo sapiens_hsa051640.47818971
94Calcium signaling pathway_Homo sapiens_hsa040200.47522483
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47464999
96RNA degradation_Homo sapiens_hsa030180.46500444
97* Cardiac muscle contraction_Homo sapiens_hsa042600.46238237
98N-Glycan biosynthesis_Homo sapiens_hsa005100.43624853
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43453074
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43222787
101Thyroid hormone synthesis_Homo sapiens_hsa049180.43120595
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42020309
103Collecting duct acid secretion_Homo sapiens_hsa049660.41322839
104Insulin secretion_Homo sapiens_hsa049110.39780951
105Alcoholism_Homo sapiens_hsa050340.38733237
106Glutamatergic synapse_Homo sapiens_hsa047240.38605855
107Non-homologous end-joining_Homo sapiens_hsa034500.38510673
108Protein digestion and absorption_Homo sapiens_hsa049740.37921446
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37660960
110Bile secretion_Homo sapiens_hsa049760.37169010
111Inositol phosphate metabolism_Homo sapiens_hsa005620.36103000
112Pyrimidine metabolism_Homo sapiens_hsa002400.35884938
113Cell cycle_Homo sapiens_hsa041100.34966430
114Renin-angiotensin system_Homo sapiens_hsa046140.34835338
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.33550133
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30861583
117Viral carcinogenesis_Homo sapiens_hsa052030.30369201
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.29402067
119* Metabolic pathways_Homo sapiens_hsa011000.27311624
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26952983
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26418640
122Pancreatic secretion_Homo sapiens_hsa049720.24592758
123Notch signaling pathway_Homo sapiens_hsa043300.24477800
124RNA polymerase_Homo sapiens_hsa030200.23758620
125Taste transduction_Homo sapiens_hsa047420.23612301
126DNA replication_Homo sapiens_hsa030300.23173136
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22910639
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21550385
129Wnt signaling pathway_Homo sapiens_hsa043100.21073414
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21024245
131Sphingolipid metabolism_Homo sapiens_hsa006000.20081668
132cAMP signaling pathway_Homo sapiens_hsa040240.19540787
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18814241
134B cell receptor signaling pathway_Homo sapiens_hsa046620.18811173
135Caffeine metabolism_Homo sapiens_hsa002320.17655175
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16666221
137Circadian entrainment_Homo sapiens_hsa047130.16644739
138Synaptic vesicle cycle_Homo sapiens_hsa047210.16579036
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16310235
140Spliceosome_Homo sapiens_hsa030400.15785011

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