CP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.10921383
2L-phenylalanine catabolic process (GO:0006559)7.10921383
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80261090
4L-phenylalanine metabolic process (GO:0006558)6.80261090
5aromatic amino acid family catabolic process (GO:0009074)6.36043484
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.03633143
7regulation of apoptotic cell clearance (GO:2000425)5.95403044
8indole-containing compound catabolic process (GO:0042436)5.73066746
9indolalkylamine catabolic process (GO:0046218)5.73066746
10tryptophan catabolic process (GO:0006569)5.73066746
11kynurenine metabolic process (GO:0070189)5.67405734
12exogenous drug catabolic process (GO:0042738)5.63602759
13bile acid biosynthetic process (GO:0006699)5.62323999
14alpha-linolenic acid metabolic process (GO:0036109)5.61943169
15negative regulation of fibrinolysis (GO:0051918)5.56780854
16positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.55129709
17complement activation, alternative pathway (GO:0006957)5.51471751
18glyoxylate metabolic process (GO:0046487)5.45468424
19regulation of protein activation cascade (GO:2000257)5.44200548
20tryptophan metabolic process (GO:0006568)5.41086319
21urea cycle (GO:0000050)5.39126353
22urea metabolic process (GO:0019627)5.39126353
23regulation of fibrinolysis (GO:0051917)5.33459026
24peptidyl-glutamic acid carboxylation (GO:0017187)5.33121985
25protein carboxylation (GO:0018214)5.33121985
26regulation of humoral immune response (GO:0002920)5.28822286
27high-density lipoprotein particle remodeling (GO:0034375)5.25571503
28cysteine metabolic process (GO:0006534)5.22601331
29intestinal cholesterol absorption (GO:0030299)5.15516178
30sulfur amino acid catabolic process (GO:0000098)5.15308921
31regulation of complement activation (GO:0030449)5.10021195
32negative regulation of complement activation (GO:0045916)5.04598958
33omega-hydroxylase P450 pathway (GO:0097267)4.99791642
34regulation of plasminogen activation (GO:0010755)4.94736456
35nitrogen cycle metabolic process (GO:0071941)4.93854893
36protein-lipid complex assembly (GO:0065005)4.81775899
37reverse cholesterol transport (GO:0043691)4.80431057
38bile acid metabolic process (GO:0008206)4.80134398
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79430319
40regulation of triglyceride catabolic process (GO:0010896)4.73684544
41serine family amino acid catabolic process (GO:0009071)4.70438440
42plasma lipoprotein particle organization (GO:0071827)4.63915390
43regulation of cholesterol esterification (GO:0010872)4.60223785
44aromatic amino acid family metabolic process (GO:0009072)4.58639609
45homocysteine metabolic process (GO:0050667)4.56045140
46plasma lipoprotein particle remodeling (GO:0034369)4.55673122
47protein-lipid complex remodeling (GO:0034368)4.55673122
48macromolecular complex remodeling (GO:0034367)4.55673122
49tyrosine metabolic process (GO:0006570)4.49853654
50amino-acid betaine metabolic process (GO:0006577)4.46308060
51negative regulation of hemostasis (GO:1900047)4.45863395
52negative regulation of blood coagulation (GO:0030195)4.45863395
53triglyceride homeostasis (GO:0070328)4.42771029
54acylglycerol homeostasis (GO:0055090)4.42771029
55phospholipid efflux (GO:0033700)4.40606885
56lysine metabolic process (GO:0006553)4.39332281
57lysine catabolic process (GO:0006554)4.39332281
58protein-lipid complex subunit organization (GO:0071825)4.37751707
59positive regulation of blood coagulation (GO:0030194)4.33696562
60positive regulation of hemostasis (GO:1900048)4.33696562
61plasma lipoprotein particle clearance (GO:0034381)4.32960964
62negative regulation of sterol transport (GO:0032372)4.31318096
63negative regulation of cholesterol transport (GO:0032375)4.31318096
64alpha-amino acid catabolic process (GO:1901606)4.29266926
65ethanol metabolic process (GO:0006067)4.26381043
66negative regulation of humoral immune response (GO:0002921)4.26310146
67ethanol oxidation (GO:0006069)4.21294517
68bile acid and bile salt transport (GO:0015721)4.16341744
69negative regulation of coagulation (GO:0050819)4.11429222
70cellular ketone body metabolic process (GO:0046950)4.09789588
71daunorubicin metabolic process (GO:0044597)4.09455111
72polyketide metabolic process (GO:0030638)4.09455111
73doxorubicin metabolic process (GO:0044598)4.09455111
74fibrinolysis (GO:0042730)4.07538405
75cholesterol efflux (GO:0033344)4.02673329
76indolalkylamine metabolic process (GO:0006586)4.02367057
77coenzyme catabolic process (GO:0009109)4.02173833
78negative regulation of wound healing (GO:0061045)4.00381485
79cellular glucuronidation (GO:0052695)3.99373814
80glutamate metabolic process (GO:0006536)3.99023274
81positive regulation of coagulation (GO:0050820)3.98382193
82cellular amino acid catabolic process (GO:0009063)3.95477953
83benzene-containing compound metabolic process (GO:0042537)3.92505330
84glycine metabolic process (GO:0006544)3.92440991
85cellular biogenic amine catabolic process (GO:0042402)3.91571354
86amine catabolic process (GO:0009310)3.91571354
87imidazole-containing compound metabolic process (GO:0052803)3.90628534
88positive regulation of extracellular matrix organization (GO:1903055)3.83076718
89serine family amino acid metabolic process (GO:0009069)3.81494119
90plasma lipoprotein particle assembly (GO:0034377)3.81435183
91cellular modified amino acid catabolic process (GO:0042219)3.81342040
92complement activation, classical pathway (GO:0006958)3.78483655
93negative regulation of lipase activity (GO:0060192)3.78455325
94dicarboxylic acid biosynthetic process (GO:0043650)3.78228431
95low-density lipoprotein particle remodeling (GO:0034374)3.77365330
96complement activation (GO:0006956)3.76481106
97regulation of bile acid biosynthetic process (GO:0070857)3.75047912
98phospholipid homeostasis (GO:0055091)3.75036199
99acute-phase response (GO:0006953)3.74431770
100acute inflammatory response (GO:0002526)3.72367393
101aldehyde catabolic process (GO:0046185)3.71598722
102arginine metabolic process (GO:0006525)3.71380070
103opsonization (GO:0008228)3.71180166
104drug metabolic process (GO:0017144)3.71167399
105positive regulation of lipid catabolic process (GO:0050996)3.71116125
106positive regulation of triglyceride lipase activity (GO:0061365)3.69587259
107positive regulation of lipoprotein lipase activity (GO:0051006)3.69587259
108protein activation cascade (GO:0072376)3.69120551
109drug catabolic process (GO:0042737)3.68588055
110regulation of cholesterol homeostasis (GO:2000188)3.65716245
111killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.63936266
112disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.63936266
113lipoprotein metabolic process (GO:0042157)3.63232036
114aminoglycoside antibiotic metabolic process (GO:0030647)3.62136254
115blood coagulation, intrinsic pathway (GO:0007597)3.61161622
116cholesterol homeostasis (GO:0042632)3.59186083
117regulation of acute inflammatory response (GO:0002673)3.57394485
118serine family amino acid biosynthetic process (GO:0009070)3.55939067
119negative regulation of protein activation cascade (GO:2000258)3.55483925
120acetyl-CoA metabolic process (GO:0006084)3.54515159
121cytolysis (GO:0019835)3.54356052
122sterol homeostasis (GO:0055092)3.54315680
123uronic acid metabolic process (GO:0006063)3.54221657
124glucuronate metabolic process (GO:0019585)3.54221657
125ketone body metabolic process (GO:1902224)3.53227250
126very-low-density lipoprotein particle assembly (GO:0034379)3.52923810
127response to nitrosative stress (GO:0051409)3.52065957
128epoxygenase P450 pathway (GO:0019373)3.50687632
129organic acid catabolic process (GO:0016054)3.49396563
130carboxylic acid catabolic process (GO:0046395)3.49396563
131cofactor catabolic process (GO:0051187)3.46852977
132positive regulation of fatty acid beta-oxidation (GO:0032000)3.46399475
133cholesterol transport (GO:0030301)3.41504287
134sterol transport (GO:0015918)3.41504287
135primary alcohol catabolic process (GO:0034310)3.40672019
136flavonoid metabolic process (GO:0009812)3.34741852
137intestinal absorption (GO:0050892)3.29557963
138regulation of cholesterol biosynthetic process (GO:0045540)3.24194376
139positive regulation of fatty acid biosynthetic process (GO:0045723)3.24016804
140embryonic retina morphogenesis in camera-type eye (GO:0060059)3.20322744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.69077576
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.59938319
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.29784151
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.08347383
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.90931186
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80982314
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.52293722
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97794343
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.45290681
10CLOCK_20551151_ChIP-Seq_293T_Human2.15570693
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08240892
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8756558
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97661201
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95519724
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83145451
16TCF4_18268006_ChIP-ChIP_LS174T_Human1.77735702
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.71528158
18GATA1_22025678_ChIP-Seq_K562_Human1.65228193
19* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63998196
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61533770
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59483945
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50596125
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50003286
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48557407
25* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34576554
26CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32327147
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.30461691
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30439825
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.24989172
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22862640
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22368454
32HTT_18923047_ChIP-ChIP_STHdh_Human1.19919251
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18530945
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.16875569
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.15464926
36ZNF263_19887448_ChIP-Seq_K562_Human1.14095679
37AR_21572438_ChIP-Seq_LNCaP_Human1.10509833
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10012930
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04368368
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03234913
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03234913
42* GATA4_25053715_ChIP-Seq_YYC3_Human1.03039314
43* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02956031
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.02806309
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.02192245
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01261694
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98002295
48RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97943199
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97508247
50SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96090272
51PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95748940
52FOXO3_23340844_ChIP-Seq_DLD1_Human0.94517710
53PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94343408
54NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93921170
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92744479
56SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91585096
57TP53_16413492_ChIP-PET_HCT116_Human0.90745654
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90541612
59PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89173676
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88249008
61* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86500383
62* AR_21909140_ChIP-Seq_LNCAP_Human0.86391037
63EZH2_27294783_Chip-Seq_NPCs_Mouse0.86309705
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84749311
65TP53_18474530_ChIP-ChIP_U2OS_Human0.84135336
66SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84049823
67OCT4_18555785_Chip-Seq_ESCs_Mouse0.81728595
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81724634
69ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81372873
70AHR_22903824_ChIP-Seq_MCF-7_Human0.80507749
71* EP300_21415370_ChIP-Seq_HL-1_Mouse0.80194983
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79116222
73CDX2_20551321_ChIP-Seq_CACO-2_Human0.78832405
74SOX2_20726797_ChIP-Seq_SW620_Human0.77924365
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77652498
76CDX2_22108803_ChIP-Seq_LS180_Human0.77346745
77ZFX_18555785_Chip-Seq_ESCs_Mouse0.77238850
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75875299
79PU1_27457419_Chip-Seq_LIVER_Mouse0.75545084
80IRF8_22096565_ChIP-ChIP_GC-B_Human0.73760988
81KLF4_18555785_Chip-Seq_ESCs_Mouse0.73136279
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72965084
83RUNX1_27457419_Chip-Seq_LIVER_Mouse0.72483314
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71012346
85CTCF_18555785_Chip-Seq_ESCs_Mouse0.70222016
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68954202
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.68788057
88SOX2_18555785_Chip-Seq_ESCs_Mouse0.68034832
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.67404592
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67200576
91P300_18555785_Chip-Seq_ESCs_Mouse0.65600237
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.65574242
93FOXA1_25552417_ChIP-Seq_VCAP_Human0.65211003
94* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64657541
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.62692859
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62497735
97GATA6_25053715_ChIP-Seq_YYC3_Human0.60872705
98* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.60363522
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.59616203
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.58688167
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58650713
102EGR1_19032775_ChIP-ChIP_M12_Human0.57959960
103LXR_22292898_ChIP-Seq_THP-1_Human0.57177799
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.56602094
105PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56223108
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.56062619
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.56047592
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.55661404
109* GATA2_19941826_ChIP-Seq_K562_Human0.54654339
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54464921
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53442377
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.53415199
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53365879
114BCAT_22108803_ChIP-Seq_LS180_Human0.52517947
115* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52336154
116CEBPB_22108803_ChIP-Seq_LS180_Human0.52011834
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.51917538
118GATA1_19941826_ChIP-Seq_K562_Human0.51395530
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.50297331
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.50297331
121* CJUN_26792858_Chip-Seq_BT549_Human0.50139601
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49867015
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.49695673
124RACK7_27058665_Chip-Seq_MCF-7_Human0.49552413
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.48384591
126CBP_21632823_ChIP-Seq_H3396_Human0.46538363
127* TP63_23658742_ChIP-Seq_EP156T_Human0.46493490
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.46313921
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45849999
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45596807
131RARB_24833708_ChIP-Seq_LIVER_Mouse0.45346252
132MYC_19915707_ChIP-ChIP_AK7_Human0.44787275
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.44577036
134AR_20517297_ChIP-Seq_VCAP_Human0.44514961
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.42981166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.03373796
2MP0005360_urolithiasis6.95636378
3MP0005085_abnormal_gallbladder_physiolo6.11728655
4MP0005365_abnormal_bile_salt5.85217317
5MP0008875_abnormal_xenobiotic_pharmacok4.84671739
6MP0003252_abnormal_bile_duct3.93913609
7MP0003806_abnormal_nucleotide_metabolis3.92176123
8MP0010329_abnormal_lipoprotein_level3.46542497
9MP0005083_abnormal_biliary_tract3.22699234
10MP0009840_abnormal_foam_cell3.09997206
11MP0003195_calcinosis2.87640297
12MP0005332_abnormal_amino_acid2.61012622
13MP0003122_maternal_imprinting2.59439269
14MP0001666_abnormal_nutrient_absorption2.56847239
15MP0003191_abnormal_cellular_cholesterol2.45403532
16MP0002138_abnormal_hepatobiliary_system2.32073384
17MP0004019_abnormal_vitamin_homeostasis2.16878320
18MP0000609_abnormal_liver_physiology2.14449321
19MP0002118_abnormal_lipid_homeostasis2.05550745
20MP0000566_synostosis1.94206985
21MP0002132_abnormal_respiratory_system1.85309256
22MP0005319_abnormal_enzyme/_coenzyme1.77282955
23MP0003868_abnormal_feces_composition1.71953753
24MP0001915_intracranial_hemorrhage1.70584773
25MP0009780_abnormal_chondrocyte_physiolo1.57373758
26MP0003705_abnormal_hypodermis_morpholog1.56773917
27MP0003011_delayed_dark_adaptation1.53488759
28MP0005584_abnormal_enzyme/coenzyme_acti1.47546561
29MP0002254_reproductive_system_inflammat1.34991441
30MP0001764_abnormal_homeostasis1.34419647
31MP0009643_abnormal_urine_homeostasis1.29155252
32MP0010368_abnormal_lymphatic_system1.24637722
33MP0009697_abnormal_copulation1.24039293
34MP0003186_abnormal_redox_activity1.22722701
35MP0006054_spinal_hemorrhage1.18235953
36MP0002089_abnormal_postnatal_growth/wei1.15004147
37MP0000598_abnormal_liver_morphology1.14132395
38MP0003656_abnormal_erythrocyte_physiolo1.13820180
39MP0009764_decreased_sensitivity_to1.13748993
40MP0000604_amyloidosis1.13198497
41MP0010234_abnormal_vibrissa_follicle1.12222843
42MP0005058_abnormal_lysosome_morphology1.06074356
43MP0005451_abnormal_body_composition1.04986663
44MP0009763_increased_sensitivity_to1.02599702
45MP0003950_abnormal_plasma_membrane1.00062552
46MP0003123_paternal_imprinting0.99839555
47MP0005647_abnormal_sex_gland0.98503091
48MP0002282_abnormal_trachea_morphology0.98066565
49MP0005408_hypopigmentation0.90881766
50MP0005409_darkened_coat_color0.87505189
51MP0005670_abnormal_white_adipose0.87216798
52MP0008469_abnormal_protein_level0.86826227
53MP0005084_abnormal_gallbladder_morpholo0.86707305
54MP0004130_abnormal_muscle_cell0.84493662
55* MP0005636_abnormal_mineral_homeostasis0.83997554
56MP0005220_abnormal_exocrine_pancreas0.83808237
57MP0009642_abnormal_blood_homeostasis0.81736855
58MP0009053_abnormal_anal_canal0.78232300
59MP0002933_joint_inflammation0.77025081
60MP0003300_gastrointestinal_ulcer0.72114462
61MP0003183_abnormal_peptide_metabolism0.71894713
62MP0002971_abnormal_brown_adipose0.71423558
63MP0009765_abnormal_xenobiotic_induced0.71095878
64MP0002078_abnormal_glucose_homeostasis0.70718256
65MP0003172_abnormal_lysosome_physiology0.69651560
66MP0003329_amyloid_beta_deposits0.69105963
67MP0001661_extended_life_span0.68831153
68MP0009384_cardiac_valve_regurgitation0.68738604
69MP0001881_abnormal_mammary_gland0.68599141
70MP0005334_abnormal_fat_pad0.68307047
71* MP0005376_homeostasis/metabolism_phenot0.66511375
72MP0002928_abnormal_bile_duct0.66509734
73* MP0005164_abnormal_response_to0.64852499
74MP0003943_abnormal_hepatobiliary_system0.63410552
75MP0002909_abnormal_adrenal_gland0.63390540
76MP0005248_abnormal_Harderian_gland0.62324986
77MP0001756_abnormal_urination0.61138763
78MP0003879_abnormal_hair_cell0.61010962
79MP0002168_other_aberrant_phenotype0.59623083
80MP0005395_other_phenotype0.59221654
81MP0005377_hearing/vestibular/ear_phenot0.58266552
82MP0003878_abnormal_ear_physiology0.58266552
83MP0002796_impaired_skin_barrier0.57040689
84MP0005666_abnormal_adipose_tissue0.56866932
85MP0002060_abnormal_skin_morphology0.56841246
86MP0005257_abnormal_intraocular_pressure0.56759566
87MP0002136_abnormal_kidney_physiology0.56642801
88MP0002876_abnormal_thyroid_physiology0.56361395
89MP0003724_increased_susceptibility_to0.56085080
90MP0006036_abnormal_mitochondrial_physio0.55745740
91MP0005464_abnormal_platelet_physiology0.54763727
92MP0000639_abnormal_adrenal_gland0.53793977
93MP0008438_abnormal_cutaneous_collagen0.53646354
94MP0005023_abnormal_wound_healing0.53183549
95MP0004782_abnormal_surfactant_physiolog0.52917938
96MP0003075_altered_response_to0.51773595
97MP0005166_decreased_susceptibility_to0.50958772
98MP0005187_abnormal_penis_morphology0.50534266
99MP0005535_abnormal_body_temperature0.50193099
100* MP0003632_abnormal_nervous_system0.49730228
101MP0005275_abnormal_skin_tensile0.49178683
102MP0003453_abnormal_keratinocyte_physiol0.48978959
103MP0000579_abnormal_nail_morphology0.48900402
104MP0005266_abnormal_metabolism0.48853051
105MP0001270_distended_abdomen0.48670182
106MP0005076_abnormal_cell_differentiation0.48432182
107MP0004043_abnormal_pH_regulation0.48427028
108MP0002128_abnormal_blood_circulation0.46742358
109MP0004264_abnormal_extraembryonic_tissu0.46609417
110MP0002295_abnormal_pulmonary_circulatio0.45926255
111MP0000858_altered_metastatic_potential0.45580600
112MP0003638_abnormal_response/metabolism_0.45511380
113MP0005448_abnormal_energy_balance0.44838067
114* MP0003690_abnormal_glial_cell0.44520367
115MP0000249_abnormal_blood_vessel0.44315574
116MP0003941_abnormal_skin_development0.42537827
117* MP0000920_abnormal_myelination0.42336546
118MP0003436_decreased_susceptibility_to0.42207628
119MP0008873_increased_physiological_sensi0.42063949
120MP0002249_abnormal_larynx_morphology0.41860509
121MP0004883_abnormal_blood_vessel0.41714725
122* MP0003631_nervous_system_phenotype0.40801637
123MP0008874_decreased_physiological_sensi0.39543748
124MP0009115_abnormal_fat_cell0.39121320
125MP0005167_abnormal_blood-brain_barrier0.38812934
126MP0000003_abnormal_adipose_tissue0.38425684
127MP0003115_abnormal_respiratory_system0.38049157
128MP0002896_abnormal_bone_mineralization0.37840209
129* MP0003633_abnormal_nervous_system0.37026627
130MP0001243_abnormal_dermal_layer0.36696363
131MP0004272_abnormal_basement_membrane0.35729392
132MP0003953_abnormal_hormone_level0.35225712
133MP0001853_heart_inflammation0.34973215
134MP0002135_abnormal_kidney_morphology0.32895556
135MP0003566_abnormal_cell_adhesion0.31960612
136MP0002837_dystrophic_cardiac_calcinosis0.31545688
137MP0006035_abnormal_mitochondrial_morpho0.31414922

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.52004376
2Intrahepatic cholestasis (HP:0001406)7.15010795
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.92255799
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54861300
5Prolonged partial thromboplastin time (HP:0003645)6.33033466
6Xanthomatosis (HP:0000991)6.20697045
7Hypobetalipoproteinemia (HP:0003563)6.12787211
8Complement deficiency (HP:0004431)5.74459211
9Hyperlipoproteinemia (HP:0010980)5.41399914
10Hypolipoproteinemia (HP:0010981)4.72089202
11Joint hemorrhage (HP:0005261)4.67914331
12Abnormality of the common coagulation pathway (HP:0010990)4.67279987
13Epidermoid cyst (HP:0200040)4.47778626
14Hyperammonemia (HP:0001987)4.38697590
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34790032
16Hypoalphalipoproteinemia (HP:0003233)4.24355173
17Abnormality of complement system (HP:0005339)4.19346330
18Hyperglycinemia (HP:0002154)4.11553294
19Fat malabsorption (HP:0002630)4.06893131
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.05160498
21Ketosis (HP:0001946)4.04314632
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.96163509
23Abnormality of methionine metabolism (HP:0010901)3.88934922
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.80854952
25Abnormality of the intrinsic pathway (HP:0010989)3.79500217
26Hypoglycemic coma (HP:0001325)3.78431019
27Hyperglycinuria (HP:0003108)3.69459025
28Abnormality of glycine metabolism (HP:0010895)3.66251006
29Abnormality of serine family amino acid metabolism (HP:0010894)3.66251006
30Hypercholesterolemia (HP:0003124)3.60724626
31Conjugated hyperbilirubinemia (HP:0002908)3.52251923
32Abnormality of pyrimidine metabolism (HP:0004353)3.35545619
33Myocardial infarction (HP:0001658)3.23197996
34Abnormality of fatty-acid metabolism (HP:0004359)3.17079425
35Hepatocellular carcinoma (HP:0001402)3.15187491
36Spontaneous abortion (HP:0005268)3.14615622
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.11579870
38Hyperbilirubinemia (HP:0002904)3.09264560
39Steatorrhea (HP:0002570)3.05035080
40Vascular calcification (HP:0004934)3.03728165
41Purpura (HP:0000979)3.02238789
42Abnormality of nucleobase metabolism (HP:0010932)3.01849725
43Ketoacidosis (HP:0001993)2.97106379
44Skin nodule (HP:0200036)2.91354672
45Systemic lupus erythematosus (HP:0002725)2.87427140
46Gout (HP:0001997)2.86941729
47Delayed CNS myelination (HP:0002188)2.86935307
48Abnormality of purine metabolism (HP:0004352)2.85001778
49Cardiovascular calcification (HP:0011915)2.82355190
50Osteomalacia (HP:0002749)2.79225151
51Abnormality of serum amino acid levels (HP:0003112)2.78791141
52Esophageal varix (HP:0002040)2.77405745
53Glomerulonephritis (HP:0000099)2.75719468
54Hypochromic microcytic anemia (HP:0004840)2.67441960
55Spastic diplegia (HP:0001264)2.60395638
56Mitral stenosis (HP:0001718)2.58378468
57Metabolic acidosis (HP:0001942)2.55626986
58Flat acetabular roof (HP:0003180)2.52054586
59Abnormality of carpal bone ossification (HP:0006257)2.50913365
60Amyloidosis (HP:0011034)2.45827039
61Abnormal tarsal ossification (HP:0008369)2.45613475
62Small epiphyses (HP:0010585)2.44605953
63Hypoglycemic seizures (HP:0002173)2.42342668
64Acanthocytosis (HP:0001927)2.41018439
65Lethargy (HP:0001254)2.38322428
66Dicarboxylic aciduria (HP:0003215)2.32967808
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32967808
68Abnormal gallbladder morphology (HP:0012437)2.32761495
69Gingival bleeding (HP:0000225)2.31631492
70Nephritis (HP:0000123)2.31166149
71Arthropathy (HP:0003040)2.28939856
72Cholelithiasis (HP:0001081)2.28100270
73Recurrent gram-negative bacterial infections (HP:0005420)2.27811059
74Malnutrition (HP:0004395)2.27415599
75Hemorrhage of the eye (HP:0011885)2.26134256
76Abnormal gallbladder physiology (HP:0012438)2.21076356
77Cholecystitis (HP:0001082)2.21076356
78Irritability (HP:0000737)2.19798235
79Neonatal onset (HP:0003623)2.19791072
80Menorrhagia (HP:0000132)2.16311784
81Sensorimotor neuropathy (HP:0007141)2.14429588
82Thrombophlebitis (HP:0004418)2.11528821
83Late onset (HP:0003584)2.11371159
84Facial shape deformation (HP:0011334)2.07862448
85Potter facies (HP:0002009)2.07862448
86Joint swelling (HP:0001386)2.03791880
87Pulmonary embolism (HP:0002204)2.01862536
88Enlarged kidneys (HP:0000105)2.01811380
89Cerebral edema (HP:0002181)2.01630295
90Pancreatitis (HP:0001733)2.01542244
91Rickets (HP:0002748)2.01142789
92Abnormal cartilage morphology (HP:0002763)1.98358961
93Abnormality of proline metabolism (HP:0010907)1.97473014
94Hydroxyprolinuria (HP:0003080)1.97473014
95Broad alveolar ridges (HP:0000187)1.95974290
96Abnormal delivery (HP:0001787)1.93540171
97Hyperinsulinemic hypoglycemia (HP:0000825)1.92972594
98Hypophosphatemic rickets (HP:0004912)1.89391142
99Increased purine levels (HP:0004368)1.89283011
100Hyperuricemia (HP:0002149)1.89283011
101Abnormality of the nasal septum (HP:0000419)1.88919529
102Bifid scrotum (HP:0000048)1.88413307
103Vomiting (HP:0002013)1.88285075
104Abnormal hand bone ossification (HP:0010660)1.86475519
105Abnormality of the gallbladder (HP:0005264)1.85821182
106Abnormal enzyme/coenzyme activity (HP:0012379)1.83837140
107Generalized aminoaciduria (HP:0002909)1.83193716
108Epistaxis (HP:0000421)1.82661828
109Opisthotonus (HP:0002179)1.82364915
110Brushfield spots (HP:0001088)1.82237764
111Hyperglycemia (HP:0003074)1.79047175
112Pancreatic islet-cell hyperplasia (HP:0004510)1.78979206
113Poikilocytosis (HP:0004447)1.78202917
114Right ventricular cardiomyopathy (HP:0011663)1.75917927
115Abnormal ossification of hand bones (HP:0005921)1.75360102
116Epiphyseal dysplasia (HP:0002656)1.73609613
117Stroke (HP:0001297)1.70931875
118Hypertriglyceridemia (HP:0002155)1.70923573
119Broad palm (HP:0001169)1.70250994
120Back pain (HP:0003418)1.70249587
121Elevated hepatic transaminases (HP:0002910)1.67874203
122Hepatoblastoma (HP:0002884)1.67686201
123Glomerulosclerosis (HP:0000096)1.65339256
124Arterial tortuosity (HP:0005116)1.64922173
125Increased serum pyruvate (HP:0003542)1.64468679
126Neoplasm of the liver (HP:0002896)1.63848340
127Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62546339
128Fair hair (HP:0002286)1.61443198
129Vaginal fistula (HP:0004320)1.56927412
130Peritonitis (HP:0002586)1.56381864
131Focal segmental glomerulosclerosis (HP:0000097)1.55977625
132Abnormality of the Achilles tendon (HP:0005109)1.55277898
133Hypothermia (HP:0002045)1.54591847
134Abnormal foot bone ossification (HP:0010675)1.53074645
135Pigmentary retinal degeneration (HP:0001146)1.52679362
136Hypoplasia of the capital femoral epiphysis (HP:0003090)1.50864233
137Abnormality of the lumbar spine (HP:0100712)1.48171080
138Papillary thyroid carcinoma (HP:0002895)1.47251755
139Abnormality of the acetabulum (HP:0003170)1.46312585
140Abnormality of the wing of the ilium (HP:0011867)1.46106340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.41319223
2SIK14.52306320
3FGFR44.17710406
4ERN14.04498295
5ICK2.90833921
6EPHA22.65346161
7WNK42.57709894
8INSRR2.54137866
9ERBB42.53879656
10MST1R2.46332127
11CDK122.45915038
12TAOK32.30608339
13LATS12.30105863
14TRIB32.28289770
15FRK2.28064474
16PKN22.22486353
17PTK62.01066655
18NEK91.77982567
19EPHB11.68494582
20AKT31.60815614
21TYK21.56415468
22MAP2K41.53130209
23FGFR21.49723106
24TYRO31.44660841
25RIPK11.43288440
26TGFBR21.42260092
27PIK3CG1.41451203
28DAPK21.41109019
29FLT31.40476706
30EPHA31.40089743
31CAMK1D1.39641232
32MAPK111.37704671
33WNK11.37260114
34FER1.35212609
35BRSK21.33921302
36STK391.30509184
37MAPKAPK31.22527101
38NLK1.18885664
39PTK21.16002906
40MAP3K71.14589237
41ERBB21.13811512
42ABL21.13736028
43JAK11.13368980
44MET1.12997387
45SGK2231.10078269
46SGK4941.10078269
47KDR1.09834628
48JAK21.06244656
49PRKAA21.05733157
50MAP3K31.04778260
51BCR1.04316118
52EEF2K1.03901910
53CDK61.02551054
54CAMK1G1.00791668
55TBK10.96932601
56EIF2AK10.96501525
57TIE10.88343016
58NTRK10.87891584
59FGFR30.87783435
60STK38L0.87595305
61PDGFRA0.87386561
62SGK20.85272237
63NTRK30.82476757
64PDK10.80334600
65CDC42BPA0.80280817
66DYRK1B0.78984686
67SGK10.78836704
68CSNK1E0.78273942
69GSK3A0.78168837
70MAP3K140.75226997
71PIK3CA0.74232756
72CSK0.74083240
73PAK30.73037759
74MAP2K10.72342892
75MAPK150.71646585
76MAP2K30.71518385
77PRKCZ0.70317936
78SIK20.69600512
79BMX0.67094696
80MAP3K20.66582123
81CAMK2G0.66499360
82RPS6KB10.65901348
83EPHB20.65897586
84LMTK20.63024959
85MAPK40.61342805
86MAP3K100.60378599
87MAP2K20.60285977
88NEK60.58886251
89CDK80.58275901
90PRKACG0.56785972
91STK380.55736016
92RET0.55277946
93IGF1R0.54525322
94EPHA40.53776224
95SGK30.53135420
96MARK20.51490881
97PINK10.51177501
98GRK60.51119048
99STK30.50605501
100PRKAA10.48907830
101YES10.48217565
102ZAP700.48058977
103TTN0.48044672
104SRC0.47701592
105EGFR0.47551386
106FGR0.46946459
107KSR20.46669969
108MAPK120.46347862
109CSNK1G10.45877206
110GRK10.45512597
111MELK0.42708772
112PDPK10.42644618
113MTOR0.42580915
114BRSK10.41688636
115MYLK0.41426556
116IKBKE0.40960562
117PDK40.40304099
118PDK30.40304099
119LRRK20.40125622
120FGFR10.39410225
121PRKG10.38320189
122MAP3K10.37322071
123CHUK0.37026154
124ABL10.36486765
125CAMKK20.35344308
126RPS6KA30.34113530
127IRAK30.33610334
128MAP3K110.33541266
129PDGFRB0.33398787
130LATS20.32723730
131CSF1R0.32605990
132PRKD10.32526944
133MATK0.31884661
134SCYL20.31822009
135PRKACB0.31257748
136PAK40.30866607
137MAP3K60.30828550
138CSNK1D0.30394787
139PRKCQ0.29892929
140CDK90.29855050
141MAP2K60.29178827
142TRPM70.28473670
143MAPK70.28472491
144CSNK1A1L0.27536880
145IRAK10.25278486
146DDR20.24535799

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.42146530
2Nitrogen metabolism_Homo sapiens_hsa009103.75609415
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32632321
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24463854
5Arginine biosynthesis_Homo sapiens_hsa002203.00699209
6Complement and coagulation cascades_Homo sapiens_hsa046102.92826965
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68249923
8Tryptophan metabolism_Homo sapiens_hsa003802.64958289
9Fatty acid degradation_Homo sapiens_hsa000712.57569761
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52376172
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38108132
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34520300
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23341363
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16986705
15Chemical carcinogenesis_Homo sapiens_hsa052042.06183487
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04459302
17Peroxisome_Homo sapiens_hsa041462.04439469
18Butanoate metabolism_Homo sapiens_hsa006502.04208038
19PPAR signaling pathway_Homo sapiens_hsa033201.97613905
20Propanoate metabolism_Homo sapiens_hsa006401.94430823
21Fatty acid metabolism_Homo sapiens_hsa012121.91938266
22Caffeine metabolism_Homo sapiens_hsa002321.91708386
23Staphylococcus aureus infection_Homo sapiens_hsa051501.87535039
24Histidine metabolism_Homo sapiens_hsa003401.85520319
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.82655688
26Retinol metabolism_Homo sapiens_hsa008301.68600898
27beta-Alanine metabolism_Homo sapiens_hsa004101.68588047
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65022717
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.60118038
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57864856
31Phenylalanine metabolism_Homo sapiens_hsa003601.56570875
32Bile secretion_Homo sapiens_hsa049761.52626573
33Selenocompound metabolism_Homo sapiens_hsa004501.49633209
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48421357
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46698230
36Tyrosine metabolism_Homo sapiens_hsa003501.43432566
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39042016
38Pyruvate metabolism_Homo sapiens_hsa006201.34391161
39Sulfur metabolism_Homo sapiens_hsa009201.30055149
40Fatty acid elongation_Homo sapiens_hsa000621.26252566
41Starch and sucrose metabolism_Homo sapiens_hsa005001.26029291
42ABC transporters_Homo sapiens_hsa020101.20862515
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.18658691
44Fat digestion and absorption_Homo sapiens_hsa049751.17358021
45Biosynthesis of amino acids_Homo sapiens_hsa012301.13014622
46Carbon metabolism_Homo sapiens_hsa012001.11397512
47Steroid biosynthesis_Homo sapiens_hsa001001.08273555
48Folate biosynthesis_Homo sapiens_hsa007901.04396120
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.98378977
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91756951
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89839951
52Vitamin digestion and absorption_Homo sapiens_hsa049770.88395893
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88202710
54Fatty acid biosynthesis_Homo sapiens_hsa000610.87222658
55Vitamin B6 metabolism_Homo sapiens_hsa007500.86926804
56Arginine and proline metabolism_Homo sapiens_hsa003300.85778419
57Sulfur relay system_Homo sapiens_hsa041220.82326560
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.80766113
59Lysine degradation_Homo sapiens_hsa003100.80434945
60Glutathione metabolism_Homo sapiens_hsa004800.75614660
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70613258
62Glycerolipid metabolism_Homo sapiens_hsa005610.68779523
63* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67160336
64Other glycan degradation_Homo sapiens_hsa005110.59496791
65Pentose phosphate pathway_Homo sapiens_hsa000300.58319267
66One carbon pool by folate_Homo sapiens_hsa006700.50524530
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49083228
68Prion diseases_Homo sapiens_hsa050200.40611572
69Metabolic pathways_Homo sapiens_hsa011000.37788529
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36605785
71N-Glycan biosynthesis_Homo sapiens_hsa005100.36547957
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.31642206
73Insulin resistance_Homo sapiens_hsa049310.31442882
74Mineral absorption_Homo sapiens_hsa049780.27525096
75Galactose metabolism_Homo sapiens_hsa000520.25241629
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21708239
77Sphingolipid metabolism_Homo sapiens_hsa006000.19467367
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18684105
79Circadian rhythm_Homo sapiens_hsa047100.16822406
80Fructose and mannose metabolism_Homo sapiens_hsa000510.16635436
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.10906847
82Glucagon signaling pathway_Homo sapiens_hsa049220.10898048
83Linoleic acid metabolism_Homo sapiens_hsa005910.09359057
84AMPK signaling pathway_Homo sapiens_hsa041520.08227178
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07971780
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00319010
87Amoebiasis_Homo sapiens_hsa051460.00285236
88Adherens junction_Homo sapiens_hsa04520-0.2004826
89Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1853138
90Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1778625
91Renin-angiotensin system_Homo sapiens_hsa04614-0.1746338
92Malaria_Homo sapiens_hsa05144-0.1530126
93Protein digestion and absorption_Homo sapiens_hsa04974-0.1485519
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1338189
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1306279
96Pertussis_Homo sapiens_hsa05133-0.1301559
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1300746
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1266400
99African trypanosomiasis_Homo sapiens_hsa05143-0.1196388
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1098327
101Lysosome_Homo sapiens_hsa04142-0.0960536
102Hepatitis C_Homo sapiens_hsa05160-0.0699465
103Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0678791
104Bladder cancer_Homo sapiens_hsa05219-0.0586474
105Insulin signaling pathway_Homo sapiens_hsa04910-0.0568334
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0499932
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0359213
108ECM-receptor interaction_Homo sapiens_hsa04512-0.0310902

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