CPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.96864265
2polyketide metabolic process (GO:0030638)9.96864265
3doxorubicin metabolic process (GO:0044598)9.96864265
4cobalamin metabolic process (GO:0009235)9.20976906
5aminoglycoside antibiotic metabolic process (GO:0030647)8.94408141
6Golgi transport vesicle coating (GO:0048200)7.79871060
7COPI coating of Golgi vesicle (GO:0048205)7.79871060
8intestinal absorption (GO:0050892)7.12388098
9cholesterol catabolic process (GO:0006707)6.48000275
10sterol catabolic process (GO:0016127)6.48000275
11neutrophil mediated immunity (GO:0002446)6.44319411
12intestinal epithelial cell development (GO:0060576)6.29310678
13transcytosis (GO:0045056)6.24864999
14endocrine pancreas development (GO:0031018)6.02353247
15icosanoid secretion (GO:0032309)5.97333716
16arachidonic acid secretion (GO:0050482)5.97333716
17peptidyl-proline hydroxylation (GO:0019511)5.86275528
18activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.79896648
19phosphatidylinositol acyl-chain remodeling (GO:0036149)5.68706690
20positive regulation of nuclease activity (GO:0032075)5.60091827
21phosphatidylserine acyl-chain remodeling (GO:0036150)5.46570372
22phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.39276931
23regulation of nuclease activity (GO:0032069)5.07843230
24cellular protein catabolic process (GO:0044257)5.05617734
25protein hydroxylation (GO:0018126)4.95055628
26endoplasmic reticulum unfolded protein response (GO:0030968)4.94810814
27glycoside metabolic process (GO:0016137)4.93876239
28progesterone metabolic process (GO:0042448)4.92822973
29fatty acid derivative transport (GO:1901571)4.90623668
30icosanoid transport (GO:0071715)4.90623668
31regulation of keratinocyte differentiation (GO:0045616)4.88350654
32primary alcohol catabolic process (GO:0034310)4.82865085
33cellular response to unfolded protein (GO:0034620)4.75794010
34innate immune response in mucosa (GO:0002227)4.61557850
35myeloid leukocyte mediated immunity (GO:0002444)4.61132389
36regulation of keratinocyte proliferation (GO:0010837)4.61052557
37ER-nucleus signaling pathway (GO:0006984)4.58383775
38response to endoplasmic reticulum stress (GO:0034976)4.57549211
39phospholipid catabolic process (GO:0009395)4.49047109
40cellular response to topologically incorrect protein (GO:0035967)4.48884175
41regulation of triglyceride catabolic process (GO:0010896)4.48559100
42proline biosynthetic process (GO:0006561)4.45354335
43polarized epithelial cell differentiation (GO:0030859)4.42493823
44cysteine metabolic process (GO:0006534)4.42101713
45COPII vesicle coating (GO:0048208)4.40371070
46nucleotide-sugar biosynthetic process (GO:0009226)4.38903669
47negative regulation of digestive system process (GO:0060457)4.38375009
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.33158375
49membrane lipid catabolic process (GO:0046466)4.31606245
50leukotriene biosynthetic process (GO:0019370)4.27515306
51ceramide catabolic process (GO:0046514)4.27378777
52water-soluble vitamin metabolic process (GO:0006767)4.06242712
53protein maturation by protein folding (GO:0022417)4.03917952
54insulin-like growth factor receptor signaling pathway (GO:0048009)4.03387685
55mitochondrial calcium ion transport (GO:0006851)3.88095923
56phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.85392441
57response to unfolded protein (GO:0006986)3.83099052
58pancreas development (GO:0031016)3.81591479
59regulation of phospholipase A2 activity (GO:0032429)3.80589897
60mucosal immune response (GO:0002385)3.75013971
61glycolipid catabolic process (GO:0019377)3.74623055
62phosphatidylserine metabolic process (GO:0006658)3.68652213
63response to topologically incorrect protein (GO:0035966)3.66336769
64negative regulation of hormone metabolic process (GO:0032351)3.63354984
65maintenance of protein localization in organelle (GO:0072595)3.63038246
66retinal metabolic process (GO:0042574)3.61815684
674-hydroxyproline metabolic process (GO:0019471)3.60200241
68antibacterial humoral response (GO:0019731)3.57683919
69cyclooxygenase pathway (GO:0019371)3.54033732
70columnar/cuboidal epithelial cell development (GO:0002066)3.52869243
71valine metabolic process (GO:0006573)3.52812389
72macroautophagy (GO:0016236)3.52184899
73regulation of acrosome reaction (GO:0060046)3.51733518
74establishment of apical/basal cell polarity (GO:0035089)3.51406954
75ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.50772828
76peptidyl-asparagine modification (GO:0018196)3.49593731
77protein N-linked glycosylation via asparagine (GO:0018279)3.48402016
78membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.42586393
79ER overload response (GO:0006983)3.41853607
80organ or tissue specific immune response (GO:0002251)3.40534230
81acute-phase response (GO:0006953)3.40203892
82retinoid metabolic process (GO:0001523)3.39328168
83zinc ion transport (GO:0006829)3.38696271
84leukotriene metabolic process (GO:0006691)3.38395108
85vesicle coating (GO:0006901)3.37878753
86Golgi organization (GO:0007030)3.34144991
87cellular modified amino acid catabolic process (GO:0042219)3.30304324
88branched-chain amino acid catabolic process (GO:0009083)3.28364585
89serine family amino acid biosynthetic process (GO:0009070)3.27539702
90antimicrobial humoral response (GO:0019730)3.27518649
91defense response to Gram-positive bacterium (GO:0050830)3.27473734
92C21-steroid hormone metabolic process (GO:0008207)3.27004385
93homocysteine metabolic process (GO:0050667)3.24361699
94phosphatidylcholine acyl-chain remodeling (GO:0036151)3.23062957
95diterpenoid metabolic process (GO:0016101)3.22261842
96glutamine metabolic process (GO:0006541)3.17799071
97phosphatidic acid metabolic process (GO:0046473)3.17222411
98phosphatidic acid biosynthetic process (GO:0006654)3.17222411
99regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.16872970
100quinone metabolic process (GO:1901661)3.16578396
101protein N-linked glycosylation (GO:0006487)3.14996221
102alditol phosphate metabolic process (GO:0052646)3.12928706
103vitamin metabolic process (GO:0006766)3.11748908
104embryonic foregut morphogenesis (GO:0048617)3.08017511
105aspartate family amino acid catabolic process (GO:0009068)3.07376763
106positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.07282017
107steroid catabolic process (GO:0006706)3.05425257
108type B pancreatic cell development (GO:0003323)3.04174437
109regulation of epidermal cell differentiation (GO:0045604)3.03048754
110membrane repolarization during action potential (GO:0086011)3.02021259
111branched-chain amino acid metabolic process (GO:0009081)3.01447750
112phototransduction, visible light (GO:0007603)2.96563224
113establishment of monopolar cell polarity (GO:0061162)2.95782468
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.95782468
115signal peptide processing (GO:0006465)2.95031835
116L-alpha-amino acid transmembrane transport (GO:1902475)2.94366064
117endothelial cell migration (GO:0043542)2.91926261
118multicellular organismal metabolic process (GO:0044236)2.91161389
119extracellular matrix disassembly (GO:0022617)2.88613945
120L-serine metabolic process (GO:0006563)2.87456995
121negative regulation of mRNA metabolic process (GO:1903312)2.84412918
122terpenoid metabolic process (GO:0006721)2.82714187
123glandular epithelial cell differentiation (GO:0002067)2.82625617
124renal absorption (GO:0070293)2.82348342
125glycoprotein catabolic process (GO:0006516)2.81200826
126glucocorticoid metabolic process (GO:0008211)2.77117250
127tetrapyrrole metabolic process (GO:0033013)2.76683345
128regulation of cardioblast differentiation (GO:0051890)2.75584812
129negative regulation of epithelial cell differentiation (GO:0030857)2.74972936
130alcohol catabolic process (GO:0046164)2.74692235
131glycine transport (GO:0015816)2.73579978
132negative regulation of epidermal cell differentiation (GO:0045605)2.72726054
133cholesterol metabolic process (GO:0008203)2.72714023
134positive regulation of triglyceride metabolic process (GO:0090208)2.71668058
135positive regulation of wound healing (GO:0090303)2.69926942
136cell proliferation involved in metanephros development (GO:0072203)2.69610928
137positive regulation of glycogen biosynthetic process (GO:0045725)2.69357130
138proline metabolic process (GO:0006560)2.67667160
139negative regulation of glycogen biosynthetic process (GO:0045719)2.67424447
140mitochondrion distribution (GO:0048311)2.64222891
141digestive system process (GO:0022600)2.63483687
142regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.62316676
143nephron epithelium morphogenesis (GO:0072088)2.61208002
144nephron tubule morphogenesis (GO:0072078)2.61208002
145negative regulation of epidermis development (GO:0045683)2.60080198
146cell redox homeostasis (GO:0045454)2.59917442
147regulation of cholesterol homeostasis (GO:2000188)2.58633317
148positive regulation of Rap GTPase activity (GO:0032854)2.58631697
149negative regulation of Notch signaling pathway (GO:0045746)2.57323920
150maternal placenta development (GO:0001893)2.55715020
151lung secretory cell differentiation (GO:0061140)2.54444231
152cellular glucuronidation (GO:0052695)2.53862361
153positive regulation of macroautophagy (GO:0016239)2.51698384
154glucuronate metabolic process (GO:0019585)2.50317717
155uronic acid metabolic process (GO:0006063)2.50317717
156cellular response to cadmium ion (GO:0071276)2.49695687
157UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49103959
158calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.47000830
159detection of visible light (GO:0009584)2.46913485
160sphingolipid catabolic process (GO:0030149)2.45616488
161cholesterol transport (GO:0030301)2.44121717
162sterol transport (GO:0015918)2.44121717
163multicellular organismal catabolic process (GO:0044243)2.40288376
164myelin maintenance (GO:0043217)2.37556024
165exocrine pancreas development (GO:0031017)16.7225122
166intestinal cholesterol absorption (GO:0030299)15.2792399
167digestion (GO:0007586)12.3516468
168protein retention in ER lumen (GO:0006621)10.6024345
169maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.2822073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.57939190
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.45429995
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.61304045
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.12409923
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.12409923
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.12409923
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.96959828
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.93049515
9GATA1_22025678_ChIP-Seq_K562_Human2.91048477
10EGR1_19032775_ChIP-ChIP_M12_Human2.70348623
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.63342868
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.49659700
13GATA6_25053715_ChIP-Seq_YYC3_Human2.47174698
14CLOCK_20551151_ChIP-Seq_293T_Human2.37036909
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.31080697
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.24658111
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.20364957
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.12997168
19* GATA4_25053715_ChIP-Seq_YYC3_Human2.12024268
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.01840075
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90235535
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89813222
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.89066674
24CHD1_26751641_Chip-Seq_LNCaP_Human1.88486326
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.85504978
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80867148
27MYC_22102868_ChIP-Seq_BL_Human1.77987813
28CREB1_26743006_Chip-Seq_LNCaP_Human1.77473452
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77230489
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.74097076
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73868395
32CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.64804431
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63279034
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.63200834
35LXR_22292898_ChIP-Seq_THP-1_Human1.58432619
36ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.58329149
37NFYA_21822215_ChIP-Seq_K562_Human1.56044540
38RACK7_27058665_Chip-Seq_MCF-7_Human1.55798295
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54040681
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.53800053
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53306287
42HNFA_21074721_ChIP-Seq_CACO-2_Human1.51185949
43GATA6_21074721_ChIP-Seq_CACO-2_Human1.49838901
44ETV1_20927104_ChIP-Seq_GIST48_Human1.49031111
45NANOG_21062744_ChIP-ChIP_HESCs_Human1.47818539
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47606121
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46446726
48PHF8_20622853_ChIP-Seq_HELA_Human1.45749436
49GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.45270295
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45144479
51CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.44939622
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44384931
53ATF3_27146783_Chip-Seq_COLON_Human1.42895454
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.41725388
55PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.41379780
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40906751
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40453848
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39800467
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39021356
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38275899
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.37093180
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36122659
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35804198
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34575826
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.34372025
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33088294
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32904530
68RBPJ_21746931_ChIP-Seq_IB4_Human1.32541084
69* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31482129
70KDM2B_26808549_Chip-Seq_K562_Human1.30654976
71P68_20966046_ChIP-Seq_HELA_Human1.30364651
72* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29779793
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.29011194
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28913042
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.27835762
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.27835762
77CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27222286
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26495311
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26118892
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23191361
81ESET_19884257_ChIP-Seq_ESCs_Mouse1.22984873
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20725775
83NFYB_21822215_ChIP-Seq_K562_Human1.19963966
84TP63_22573176_ChIP-Seq_HFKS_Human1.19136262
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.17881758
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17772460
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17565036
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16015014
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15161441
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13656677
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13613775
92CBP_21632823_ChIP-Seq_H3396_Human1.12895821
93FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11745313
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11596508
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11042009
96FOXA1_25552417_ChIP-Seq_VCAP_Human1.09963359
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.09797073
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08065031
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.07128120
100GATA3_24758297_ChIP-Seq_MCF-7_Human1.06991536
101* HTT_18923047_ChIP-ChIP_STHdh_Human1.05227206
102AR_21909140_ChIP-Seq_LNCAP_Human1.03739136
103NCOR1_26117541_ChIP-Seq_K562_Human1.02531324
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01863574
105KDM2B_26808549_Chip-Seq_DND41_Human1.01667004
106GATA1_19941826_ChIP-Seq_K562_Human1.00621242
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00439514
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00439514
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00281413
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00124353
111* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99662662
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99620955
113* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99016176
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98945964
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98355193
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98108688
117CJUN_26792858_Chip-Seq_BT549_Human0.97897453
118CTCF_27219007_Chip-Seq_Bcells_Human0.97616339
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97616187
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97305833
121* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96807259
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96411697
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95697172
124SOX2_20726797_ChIP-Seq_SW620_Human0.95656813
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95436339
126CEBPB_22108803_ChIP-Seq_LS180_Human0.94760082
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94588578
128ZNF263_19887448_ChIP-Seq_K562_Human0.93701224
129* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93251138
130TCF7_22412390_ChIP-Seq_EML_Mouse0.93120955
131FOXH1_21741376_ChIP-Seq_ESCs_Human0.93094205
132TBL1_22424771_ChIP-Seq_293T_Human0.92320377
133ERG_20517297_ChIP-Seq_VCAP_Human0.92093504
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92087010
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91954544
136FLI1_21867929_ChIP-Seq_CD8_Mouse0.90911605
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90814074
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90649362
139EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90178350
140TP53_18474530_ChIP-ChIP_U2OS_Human0.88678464
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88415172
142TAF2_19829295_ChIP-Seq_ESCs_Human0.86309837
143* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86064847
144FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83407967
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82580542
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78733338
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78605815
148CDX2_22108803_ChIP-Seq_LS180_Human0.78301769
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77503778
150SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77161568
151ETS1_21867929_ChIP-Seq_TH2_Mouse0.76868030
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76349252
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.75253590
154AR_20517297_ChIP-Seq_VCAP_Human0.73758229
155ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73085668
156LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72639052
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.72386130
158SA1_27219007_Chip-Seq_Bcells_Human0.71760180
159TAF15_26573619_Chip-Seq_HEK293_Human0.70850652
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70603035
161CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69767049
162FOXA1_25329375_ChIP-Seq_VCAP_Human0.68457556
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.68457556
164NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.68171992
165TRIM28_21343339_ChIP-Seq_HEK293_Human0.67741644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.67796735
2MP0001666_abnormal_nutrient_absorption7.43688824
3MP0005220_abnormal_exocrine_pancreas5.85218617
4MP0003868_abnormal_feces_composition5.20579139
5MP0005084_abnormal_gallbladder_morpholo4.89798451
6MP0005365_abnormal_bile_salt4.88174678
7MP0003122_maternal_imprinting3.44073343
8MP0003283_abnormal_digestive_organ3.28032189
9MP0005085_abnormal_gallbladder_physiolo2.85421058
10MP0004264_abnormal_extraembryonic_tissu2.61115825
11MP0003705_abnormal_hypodermis_morpholog2.57817972
12MP0002693_abnormal_pancreas_physiology2.51996926
13MP0003123_paternal_imprinting2.50324750
14MP0001944_abnormal_pancreas_morphology2.42722005
15MP0010386_abnormal_urinary_bladder2.42403670
16MP0010234_abnormal_vibrissa_follicle2.38826525
17MP0003959_abnormal_lean_body2.33463335
18MP0002138_abnormal_hepatobiliary_system2.25927842
19MP0001664_abnormal_digestion2.06851170
20MP0006054_spinal_hemorrhage2.01887092
21MP0002928_abnormal_bile_duct1.84694036
22MP0003252_abnormal_bile_duct1.74936334
23MP0002139_abnormal_hepatobiliary_system1.72114506
24MP0008438_abnormal_cutaneous_collagen1.55797594
25MP0004233_abnormal_muscle_weight1.51424181
26MP0003195_calcinosis1.32402978
27MP0003119_abnormal_digestive_system1.18933701
28MP0003121_genomic_imprinting1.17133190
29MP0005448_abnormal_energy_balance1.16477381
30MP0004272_abnormal_basement_membrane1.15354165
31MP0008961_abnormal_basal_metabolism1.05436171
32MP0009672_abnormal_birth_weight1.04230650
33MP0000470_abnormal_stomach_morphology1.03299026
34MP0002163_abnormal_gland_morphology1.02154957
35MP0002132_abnormal_respiratory_system1.01991623
36MP0009780_abnormal_chondrocyte_physiolo1.01887275
37MP0000003_abnormal_adipose_tissue1.01242709
38MP0008004_abnormal_stomach_pH1.00907275
39MP0002876_abnormal_thyroid_physiology1.00538493
40MP0009703_decreased_birth_body0.99873191
41MP0009384_cardiac_valve_regurgitation0.95536255
42MP0003941_abnormal_skin_development0.94390679
43MP0002078_abnormal_glucose_homeostasis0.91715165
44MP0002118_abnormal_lipid_homeostasis0.88215152
45MP0003638_abnormal_response/metabolism_0.88118945
46MP0005408_hypopigmentation0.84874183
47MP0000613_abnormal_salivary_gland0.82478312
48MP0002909_abnormal_adrenal_gland0.81208891
49MP0003115_abnormal_respiratory_system0.79772097
50MP0000537_abnormal_urethra_morphology0.78506130
51MP0003300_gastrointestinal_ulcer0.78238870
52MP0000490_abnormal_crypts_of0.77925025
53MP0003045_fibrosis0.76193328
54MP0005451_abnormal_body_composition0.74922780
55MP0001756_abnormal_urination0.73960349
56MP0000462_abnormal_digestive_system0.73188785
57MP0005076_abnormal_cell_differentiation0.72614046
58MP0002896_abnormal_bone_mineralization0.70584987
59MP0004185_abnormal_adipocyte_glucose0.67987035
60MP0002938_white_spotting0.67287493
61MP0009840_abnormal_foam_cell0.66481030
62MP0010352_gastrointestinal_tract_polyps0.64504500
63MP0003942_abnormal_urinary_system0.64397585
64MP0003011_delayed_dark_adaptation0.64264936
65MP0005379_endocrine/exocrine_gland_phen0.62161769
66MP0010329_abnormal_lipoprotein_level0.61655573
67MP0003953_abnormal_hormone_level0.61368847
68MP0009643_abnormal_urine_homeostasis0.60286219
69MP0010678_abnormal_skin_adnexa0.60139835
70MP0003943_abnormal_hepatobiliary_system0.59580408
71MP0001270_distended_abdomen0.59222381
72MP0004197_abnormal_fetal_growth/weight/0.58757359
73MP0003866_abnormal_defecation0.58539045
74MP0005319_abnormal_enzyme/_coenzyme0.57592759
75MP0005165_increased_susceptibility_to0.57582749
76MP0002089_abnormal_postnatal_growth/wei0.56842060
77MP0005187_abnormal_penis_morphology0.55896895
78MP0005332_abnormal_amino_acid0.53671121
79MP0003693_abnormal_embryo_hatching0.52909518
80MP0003567_abnormal_fetal_cardiomyocyte0.52483657
81MP0004019_abnormal_vitamin_homeostasis0.50371592
82MP0002277_abnormal_respiratory_mucosa0.50110801
83MP0002877_abnormal_melanocyte_morpholog0.50042775
84MP0005375_adipose_tissue_phenotype0.49338813
85MP0005623_abnormal_meninges_morphology0.49058611
86MP0008260_abnormal_autophagy0.49037961
87MP0003787_abnormal_imprinting0.48187510
88MP0000013_abnormal_adipose_tissue0.48047461
89MP0000598_abnormal_liver_morphology0.47844079
90MP0003566_abnormal_cell_adhesion0.47169526
91MP0001849_ear_inflammation0.46700733
92MP0002970_abnormal_white_adipose0.46293997
93MP0003879_abnormal_hair_cell0.46072003
94MP0001731_abnormal_postnatal_growth0.45623538
95MP0005058_abnormal_lysosome_morphology0.45298457
96MP0001845_abnormal_inflammatory_respons0.45051824
97MP0005636_abnormal_mineral_homeostasis0.44260023
98MP0000566_synostosis0.43831557
99MP0002060_abnormal_skin_morphology0.43305358
100MP0000367_abnormal_coat/_hair0.43209290
101MP0005452_abnormal_adipose_tissue0.42821238
102MP0001765_abnormal_ion_homeostasis0.42147285
103MP0004858_abnormal_nervous_system0.41896627
104MP0000428_abnormal_craniofacial_morphol0.40676297
105MP0001340_abnormal_eyelid_morphology0.40459394
106MP0002098_abnormal_vibrissa_morphology0.39495044
107MP0004043_abnormal_pH_regulation0.39342878
108MP0002822_catalepsy0.39276842
109MP0009642_abnormal_blood_homeostasis0.38637195
110MP0000534_abnormal_ureter_morphology0.38350160
111MP0000377_abnormal_hair_follicle0.37584708
112MP0000747_muscle_weakness0.36715565
113MP0001502_abnormal_circadian_rhythm0.35394305
114MP0002168_other_aberrant_phenotype0.34509115
115MP0000538_abnormal_urinary_bladder0.34226728
116MP0008875_abnormal_xenobiotic_pharmacok0.34219200
117MP0003656_abnormal_erythrocyte_physiolo0.34065103
118MP0008872_abnormal_physiological_respon0.33113061
119MP0002796_impaired_skin_barrier0.33029602
120MP0005381_digestive/alimentary_phenotyp0.31180585
121MP0002084_abnormal_developmental_patter0.30730443
122MP0003385_abnormal_body_wall0.30509802
123MP0002234_abnormal_pharynx_morphology0.30280945
124MP0000609_abnormal_liver_physiology0.30186058
125MP0001501_abnormal_sleep_pattern0.29993849
126MP0010368_abnormal_lymphatic_system0.29718374
127MP0005535_abnormal_body_temperature0.28710998
128MP0001730_embryonic_growth_arrest0.28068822
129MP0005334_abnormal_fat_pad0.27943332
130MP0001873_stomach_inflammation0.27766139
131MP0002086_abnormal_extraembryonic_tissu0.27504456
132MP0000858_altered_metastatic_potential0.27377123
133MP0004134_abnormal_chest_morphology0.27077508
134MP0001286_abnormal_eye_development0.26980072
135MP0000733_abnormal_muscle_development0.26669635
136MP0005166_decreased_susceptibility_to0.25983974
137MP0008469_abnormal_protein_level0.25759703
138MP0000639_abnormal_adrenal_gland0.25163971
139MP0003950_abnormal_plasma_membrane0.25086034
140MP0003329_amyloid_beta_deposits0.24235681
141MP0002136_abnormal_kidney_physiology0.24123572
142MP0006035_abnormal_mitochondrial_morpho0.23889900
143MP0005595_abnormal_vascular_smooth0.22810653
144MP0009763_increased_sensitivity_to0.22398272
145MP0003091_abnormal_cell_migration0.21420216
146MP0003436_decreased_susceptibility_to0.21235113
147MP0005621_abnormal_cell_physiology0.19374824
148MP0009764_decreased_sensitivity_to0.18961485
149MP0003956_abnormal_body_size0.18914949
150MP0003828_pulmonary_edema0.18701683
151MP0005410_abnormal_fertilization0.18611870

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)6.34117562
2Tetraparesis (HP:0002273)5.80738480
3Abnormal pancreas size (HP:0012094)5.65487582
4Abnormality of the pancreatic islet cells (HP:0006476)5.49341345
5Abnormality of endocrine pancreas physiology (HP:0012093)5.49341345
6Exocrine pancreatic insufficiency (HP:0001738)5.45168046
7Fat malabsorption (HP:0002630)5.39986501
8Gout (HP:0001997)5.18512864
9Decreased subcutaneous fat (HP:0001002)4.22947730
10Abnormality of proline metabolism (HP:0010907)4.17356962
11Hydroxyprolinuria (HP:0003080)4.17356962
12Late onset (HP:0003584)4.11005747
13Hypoproteinemia (HP:0003075)4.05936325
14Short chin (HP:0000331)3.99214609
15Ketoacidosis (HP:0001993)3.97732002
16Abnormality of subcutaneous fat tissue (HP:0001001)3.94317704
17Type I diabetes mellitus (HP:0100651)3.83314973
18Maternal diabetes (HP:0009800)3.42421958
19Pancreatic islet-cell hyperplasia (HP:0004510)3.31660261
20Abnormality of the intrinsic pathway (HP:0010989)3.31097768
21Asymmetry of the thorax (HP:0001555)3.30804095
22Sex reversal (HP:0012245)3.22888381
23Abnormal sex determination (HP:0012244)3.22888381
24Hyperinsulinemic hypoglycemia (HP:0000825)3.20081886
25Rectal prolapse (HP:0002035)3.17566950
26Hypotension (HP:0002615)3.10952382
27Hypoglycemic coma (HP:0001325)3.02088412
28Ketosis (HP:0001946)2.99289390
29Absent eyelashes (HP:0000561)2.98570819
30Anal atresia (HP:0002023)2.96863491
31Hypoglycemic seizures (HP:0002173)2.96826069
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96228387
33Enlarged penis (HP:0000040)2.95731440
34Lymphangioma (HP:0100764)2.91832466
35Hyperglycemia (HP:0003074)2.88351289
36Tubulointerstitial fibrosis (HP:0005576)2.86468388
37Vascular calcification (HP:0004934)2.80297621
38Pancreatitis (HP:0001733)2.80223672
39Hepatoblastoma (HP:0002884)2.78736266
40Male infertility (HP:0003251)2.78514860
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.73459191
42Large for gestational age (HP:0001520)2.73360391
43Hypoplasia of the pons (HP:0012110)2.70257891
44Unilateral renal agenesis (HP:0000122)2.62583592
45Paraparesis (HP:0002385)2.61258166
46Type I transferrin isoform profile (HP:0003642)2.59406244
47Germ cell neoplasia (HP:0100728)2.56716603
48Ankyloglossia (HP:0010296)2.53939892
49Ileus (HP:0002595)2.53918330
50Insulin resistance (HP:0000855)2.53132535
51Esophageal varix (HP:0002040)2.52454212
52Ventricular fibrillation (HP:0001663)2.51876050
53Reduced antithrombin III activity (HP:0001976)2.50967120
54Joint stiffness (HP:0001387)2.48573053
55Cardiovascular calcification (HP:0011915)2.44839773
56Abnormality of the pons (HP:0007361)2.43297540
57Congenital glaucoma (HP:0001087)2.40309248
58Vertebral compression fractures (HP:0002953)2.32840802
59Abnormality of the common coagulation pathway (HP:0010990)2.32455729
60Thin bony cortex (HP:0002753)2.31734744
61Right ventricular cardiomyopathy (HP:0011663)2.31419453
62Cortical dysplasia (HP:0002539)2.30811255
63Abnormality of small intestinal villus morphology (HP:0011472)2.29493125
64Villous atrophy (HP:0011473)2.29493125
65Abnormality of dentin (HP:0010299)2.25221798
66Insulin-resistant diabetes mellitus (HP:0000831)2.24899141
67Abnormal protein glycosylation (HP:0012346)2.22830175
68Abnormal glycosylation (HP:0012345)2.22830175
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22830175
70Abnormal protein N-linked glycosylation (HP:0012347)2.22830175
71Premature skin wrinkling (HP:0100678)2.21679464
72Renal duplication (HP:0000075)2.19582089
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17270571
74Type II lissencephaly (HP:0007260)2.14643536
75Fragile skin (HP:0001030)2.12945006
76Atrophic scars (HP:0001075)2.10299420
77Hyperuricemia (HP:0002149)2.08722553
78Increased purine levels (HP:0004368)2.08722553
79Fatigue (HP:0012378)2.08407098
80Testicular neoplasm (HP:0010788)2.07463410
81Stenosis of the external auditory canal (HP:0000402)2.05091027
82Thoracolumbar scoliosis (HP:0002944)2.03067575
83Abnormal biliary tract morphology (HP:0012440)2.01435854
84Tubular atrophy (HP:0000092)2.00942759
85Enlarged kidneys (HP:0000105)2.00897898
86Pectus carinatum (HP:0000768)1.99086738
87Carpal bone hypoplasia (HP:0001498)1.98426807
88Symptomatic seizures (HP:0011145)1.97275260
89Macroorchidism (HP:0000053)1.95914503
90Mitral valve prolapse (HP:0001634)1.93508017
91Facial shape deformation (HP:0011334)1.92665431
92Potter facies (HP:0002009)1.92665431
93Diastasis recti (HP:0001540)1.92241784
94Subacute progressive viral hepatitis (HP:0006572)1.91907757
95Cerebral aneurysm (HP:0004944)1.88849467
96Popliteal pterygium (HP:0009756)1.88582600
97Lower limb hyperreflexia (HP:0002395)1.88577917
98Buphthalmos (HP:0000557)1.85171789
99Abnormality of methionine metabolism (HP:0010901)1.85040958
100Ankle contracture (HP:0006466)1.84794090
101Micronodular cirrhosis (HP:0001413)1.82234388
102Severe short stature (HP:0003510)1.78740734
103Tubulointerstitial nephritis (HP:0001970)1.77712455
104Prenatal maternal abnormality (HP:0002686)1.76086182
105Abnormality of oral frenula (HP:0000190)1.75115359
106Cerebellar dysplasia (HP:0007033)1.74826618
107Patent foramen ovale (HP:0001655)1.73817870
108Glossoptosis (HP:0000162)1.73305892
109Slender long bone (HP:0003100)1.73079831
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69977473
111Shallow orbits (HP:0000586)1.69863885
112Hyperphosphatemia (HP:0002905)1.68751404
113Bladder diverticulum (HP:0000015)1.68151888
114Neonatal death (HP:0003811)1.67879273
115Striae distensae (HP:0001065)1.65061218
116Mildly elevated creatine phosphokinase (HP:0008180)1.62675024
117Absent eyebrow (HP:0002223)1.62515415
118Small epiphyses (HP:0010585)1.62293886
119Aneurysm (HP:0002617)1.61240472
120Periodontitis (HP:0000704)1.60092685
121Blue sclerae (HP:0000592)1.59030010
122Epiphyseal dysplasia (HP:0002656)1.59009855
123Abdominal pain (HP:0002027)1.57154756
124Bicornuate uterus (HP:0000813)1.56950772
125Protrusio acetabuli (HP:0003179)1.55682830
126Abnormality of the distal phalanges of the toes (HP:0010182)1.55232882
127Abnormality of the pleura (HP:0002103)1.54792472
128Congenital malformation of the right heart (HP:0011723)1.54288370
129Double outlet right ventricle (HP:0001719)1.54288370
130Disproportionate tall stature (HP:0001519)1.54251133
131Large hands (HP:0001176)1.54193035
132Turricephaly (HP:0000262)1.52543080
133Hyperextensible skin (HP:0000974)1.52361813
134Hypoplasia of the odontoid process (HP:0003311)1.52100350
135Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.51843133
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.45008539
137Malnutrition (HP:0004395)1.44717006
138Abnormality of sulfur amino acid metabolism (HP:0004339)1.41712483
139Abnormal hemoglobin (HP:0011902)1.39819282
140Increased CSF protein (HP:0002922)1.37649695
141Spastic paraparesis (HP:0002313)1.31631196
142Abnormality of the right ventricle (HP:0001707)1.30811193
143Bifid uvula (HP:0000193)1.28075014
144Abnormality of alkaline phosphatase activity (HP:0004379)1.27704583
145Azoospermia (HP:0000027)1.27552445
146Congenital, generalized hypertrichosis (HP:0004540)1.23710146
147Elevated alkaline phosphatase (HP:0003155)1.23577708
148Neoplasm of the pancreas (HP:0002894)1.22709408
149Abnormality of the nasal septum (HP:0000419)1.22150817
150Abnormal enzyme/coenzyme activity (HP:0012379)1.21793283
151Abnormal cartilage morphology (HP:0002763)1.20775067
152Hyperammonemia (HP:0001987)1.20261682
153Abnormality of the Achilles tendon (HP:0005109)1.19020271
154Hypercalciuria (HP:0002150)1.18554712
155Abnormality of fatty-acid metabolism (HP:0004359)1.15896220
156Dysostosis multiplex (HP:0000943)1.15038189
157Abnormality of chloride homeostasis (HP:0011422)1.11812601
158Dehydration (HP:0001944)1.08343541
159Portal hypertension (HP:0001409)1.07663084
160Tubulointerstitial abnormality (HP:0001969)1.06568971
161Urinary glycosaminoglycan excretion (HP:0003541)1.05224744
162Mucopolysacchariduria (HP:0008155)1.05224744
163Skin pits (HP:0100276)1.05045772
164Preauricular pit (HP:0004467)1.02931008
165Periauricular skin pits (HP:0100277)1.02931008
166Abnormality of monocarboxylic acid metabolism (HP:0010996)1.02632258
167Brushfield spots (HP:0001088)1.01559283
168Epiphyseal stippling (HP:0010655)1.01484411
169Gowers sign (HP:0003391)1.00762407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.54405134
2TRIB35.50652407
3PKN25.36881593
4EPHA25.30911801
5PDK24.82016642
6ERN13.85488361
7MAP3K33.53023800
8TAOK33.09869024
9LATS13.01689090
10EIF2AK12.87353989
11EIF2AK32.85472637
12MAP2K22.85050637
13INSRR2.60720605
14PTK62.37219418
15PASK2.28108476
16MST1R2.15179921
17TBK12.12045611
18EEF2K2.06786254
19RIPK11.94485991
20FRK1.85807315
21MAP3K121.85576510
22PDGFRA1.79872408
23MAP3K101.79848802
24ERBB41.75969225
25GRK11.71155341
26FLT31.70759690
27RPS6KB21.67686992
28STK161.56000415
29PRKD31.55852886
30SCYL21.54915928
31PAK21.53800056
32NEK61.52348490
33MAPK151.51001559
34IRAK11.41866886
35NTRK31.38876958
36PRKG21.38684551
37PDGFRB1.35311429
38MAP3K21.35022436
39LRRK21.34824751
40MST41.32479171
41RET1.25546946
42ZAP701.25135239
43WNK41.24898623
44NLK1.17671733
45MAP2K11.17094246
46PTK21.16318973
47PIM21.10655426
48CAMKK11.09904913
49MTOR1.08265785
50KSR21.02764120
51HIPK20.99383436
52FER0.98708201
53FGFR40.98559398
54PAK40.97355728
55MET0.95996900
56TRPM70.92482236
57EPHA30.92216902
58TAOK20.91800277
59MAPKAPK30.90306789
60SIK10.89463208
61BMPR1B0.86555856
62MAP3K10.85680957
63TESK10.85575769
64IRAK20.84899925
65CDK190.84729431
66DYRK1B0.81400953
67NTRK10.79663627
68ILK0.76628789
69DDR20.76480279
70PRKCH0.71229422
71PRKCI0.68231451
72DAPK10.68158050
73STK390.63582988
74TAOK10.60569888
75CDK40.59686128
76MAP3K50.57401568
77LATS20.57102615
78ERBB20.56564773
79STK240.55853376
80ERBB30.54497504
81PRKCE0.54239287
82IRAK30.54018514
83STK30.52630886
84PRKD20.52416675
85MAP3K80.51503944
86EPHB10.47456493
87MYLK0.44512487
88MAP4K20.44101984
89DYRK1A0.44048721
90JAK10.43897768
91PRKD10.43858556
92STK380.43214555
93FGFR10.43041185
94BCR0.41107563
95ARAF0.40772830
96FGFR30.40596202
97MAP3K140.39620754
98DAPK20.39417512
99CSNK1E0.38071111
100PDK10.38018130
101ROCK10.37883532
102SGK30.37141017
103NME10.36504012
104CSNK1A1L0.35113572
105CSNK1G10.35058695
106WNK10.33275864
107MAPK10.33037880
108MAP3K70.32589294
109TYRO30.32518033
110JAK20.31629262
111LMTK20.31196825
112ACVR1B0.30337672
113CSNK1G20.30045572
114MELK0.28766100
115PRKCZ0.28718068
116MAPK70.28019406
117GSK3A0.28013037
118PRKAA10.27657687
119OXSR10.27524258
120ICK0.26220174
121ALK0.25752967
122MAPK30.25374019
123PDPK10.25107817
124AKT10.25018761
125CDK60.24934732
126RPS6KA10.24893603
127MOS0.24792343
128PRKACB0.24348246
129CDK90.23110365
130PIK3CA0.22955215
131MAP3K90.22055329
132IGF1R0.21904686
133CSNK1G30.21406976
134KSR10.21163527
135UHMK10.20716764
136DAPK30.19855217
137FGFR20.19323516
138PRKDC0.18960024
139TGFBR20.18194442
140STK38L0.18179758
141MAPK90.18073675
142SGK20.17026648
143TSSK60.16950609
144NEK10.16925530
145NEK90.16683902
146CAMK40.16612239
147NME20.16402375
148PAK30.16047872
149MAP3K40.15645926
150AKT20.15505160
151MAPK140.14742111
152EIF2AK20.14717471
153MAP3K110.14651255
154CDK80.14606343
155BMPR20.14442049
156MAP2K60.13160297
157PRKCA0.12847531
158MUSK0.12845605

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.05785673
2Fat digestion and absorption_Homo sapiens_hsa049756.30636156
3Maturity onset diabetes of the young_Homo sapiens_hsa049506.21286885
4* Protein digestion and absorption_Homo sapiens_hsa049745.47867431
5Glycerolipid metabolism_Homo sapiens_hsa005613.17441325
6Protein export_Homo sapiens_hsa030602.87729138
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.64028555
8Folate biosynthesis_Homo sapiens_hsa007901.71399639
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63452354
10Steroid biosynthesis_Homo sapiens_hsa001001.48715200
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48004570
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.36061455
13Notch signaling pathway_Homo sapiens_hsa043301.33364021
14Insulin secretion_Homo sapiens_hsa049111.29219835
15N-Glycan biosynthesis_Homo sapiens_hsa005101.27388349
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15828866
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07923230
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00961982
19Arachidonic acid metabolism_Homo sapiens_hsa005900.97694538
20Vitamin digestion and absorption_Homo sapiens_hsa049770.95108676
21Ether lipid metabolism_Homo sapiens_hsa005650.93696567
22Renin-angiotensin system_Homo sapiens_hsa046140.93529185
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89638452
24Propanoate metabolism_Homo sapiens_hsa006400.84218594
25Selenocompound metabolism_Homo sapiens_hsa004500.83488796
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76286079
27Starch and sucrose metabolism_Homo sapiens_hsa005000.75384974
28Arginine and proline metabolism_Homo sapiens_hsa003300.73753570
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71750901
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70668522
31Glutathione metabolism_Homo sapiens_hsa004800.67372102
32Steroid hormone biosynthesis_Homo sapiens_hsa001400.64982723
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62667984
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60552995
35Linoleic acid metabolism_Homo sapiens_hsa005910.59520556
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59004305
37Vibrio cholerae infection_Homo sapiens_hsa051100.58939568
38Biosynthesis of amino acids_Homo sapiens_hsa012300.57803938
39Endometrial cancer_Homo sapiens_hsa052130.57740470
40Influenza A_Homo sapiens_hsa051640.57385944
41Sulfur metabolism_Homo sapiens_hsa009200.56656617
42One carbon pool by folate_Homo sapiens_hsa006700.55337036
43Vitamin B6 metabolism_Homo sapiens_hsa007500.54026667
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53751669
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52585668
46Thyroid cancer_Homo sapiens_hsa052160.52175219
47Adherens junction_Homo sapiens_hsa045200.51106844
48Lysine degradation_Homo sapiens_hsa003100.50929712
49Estrogen signaling pathway_Homo sapiens_hsa049150.48989502
50Bladder cancer_Homo sapiens_hsa052190.48752221
51Tight junction_Homo sapiens_hsa045300.47986170
52Chemical carcinogenesis_Homo sapiens_hsa052040.47120089
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46718606
54Nitrogen metabolism_Homo sapiens_hsa009100.45411352
55mTOR signaling pathway_Homo sapiens_hsa041500.44435696
56Fatty acid degradation_Homo sapiens_hsa000710.44080154
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43985975
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43445296
59Type II diabetes mellitus_Homo sapiens_hsa049300.42594446
60Thyroid hormone synthesis_Homo sapiens_hsa049180.42562115
61Tryptophan metabolism_Homo sapiens_hsa003800.41610162
62Circadian rhythm_Homo sapiens_hsa047100.41449059
63Insulin resistance_Homo sapiens_hsa049310.39559205
64Cocaine addiction_Homo sapiens_hsa050300.38504354
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37096746
66VEGF signaling pathway_Homo sapiens_hsa043700.36626881
67Prostate cancer_Homo sapiens_hsa052150.35859665
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.35528070
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34780167
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34555609
71beta-Alanine metabolism_Homo sapiens_hsa004100.30714224
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30243348
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29475005
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29141501
75Type I diabetes mellitus_Homo sapiens_hsa049400.28269650
76Pancreatic cancer_Homo sapiens_hsa052120.27398491
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26683709
78Sphingolipid metabolism_Homo sapiens_hsa006000.25378948
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24600851
80Metabolic pathways_Homo sapiens_hsa011000.24252328
81Hippo signaling pathway_Homo sapiens_hsa043900.24013445
82Fructose and mannose metabolism_Homo sapiens_hsa000510.23153474
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23039386
84Other glycan degradation_Homo sapiens_hsa005110.22823359
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.21182629
86Legionellosis_Homo sapiens_hsa051340.21037346
87Pyruvate metabolism_Homo sapiens_hsa006200.20589002
88Gastric acid secretion_Homo sapiens_hsa049710.19013815
89ECM-receptor interaction_Homo sapiens_hsa045120.18704830
90Galactose metabolism_Homo sapiens_hsa000520.18524502
91Focal adhesion_Homo sapiens_hsa045100.18191062
92Insulin signaling pathway_Homo sapiens_hsa049100.17965368
93Ovarian steroidogenesis_Homo sapiens_hsa049130.17707178
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.16919512
95Small cell lung cancer_Homo sapiens_hsa052220.16907084
96Glucagon signaling pathway_Homo sapiens_hsa049220.16495935
97Hepatitis C_Homo sapiens_hsa051600.16229562
98Retinol metabolism_Homo sapiens_hsa008300.15955046
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15657865
100Chronic myeloid leukemia_Homo sapiens_hsa052200.15473920
101Non-small cell lung cancer_Homo sapiens_hsa052230.15430161
102Colorectal cancer_Homo sapiens_hsa052100.14644034
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14332299
104Bile secretion_Homo sapiens_hsa049760.13869822
105Cholinergic synapse_Homo sapiens_hsa047250.13544531
106Histidine metabolism_Homo sapiens_hsa003400.12851620
107Platelet activation_Homo sapiens_hsa046110.12736765
108AMPK signaling pathway_Homo sapiens_hsa041520.12307785
109Toxoplasmosis_Homo sapiens_hsa051450.11816958
110Viral myocarditis_Homo sapiens_hsa054160.11801578
111Proteasome_Homo sapiens_hsa030500.11405082
112Dorso-ventral axis formation_Homo sapiens_hsa043200.11085785
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10697432
114Gap junction_Homo sapiens_hsa045400.10671263
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10641531
116Butanoate metabolism_Homo sapiens_hsa006500.10018319
117Prion diseases_Homo sapiens_hsa050200.09944911
118Lysosome_Homo sapiens_hsa041420.09757028
119Mineral absorption_Homo sapiens_hsa049780.08890451
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08746429
121Rap1 signaling pathway_Homo sapiens_hsa040150.08738348
122Melanogenesis_Homo sapiens_hsa049160.07749667
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.07703257
124ABC transporters_Homo sapiens_hsa020100.07441291
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.07297275
126Pentose phosphate pathway_Homo sapiens_hsa000300.06985710
127Complement and coagulation cascades_Homo sapiens_hsa046100.06723429
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.06600542
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06296208
130Peroxisome_Homo sapiens_hsa041460.05253357
131Sulfur relay system_Homo sapiens_hsa041220.04758939
132Regulation of autophagy_Homo sapiens_hsa041400.02313818
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01858952
134Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.1047598
135TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1046691
136HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1026224
137TNF signaling pathway_Homo sapiens_hsa04668-0.0967560
138Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0887477
139Arginine biosynthesis_Homo sapiens_hsa00220-0.0783560
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0772612
141Ras signaling pathway_Homo sapiens_hsa04014-0.0743016
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0736869
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0728225
144Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0682083
145Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0538595
146Phototransduction_Homo sapiens_hsa04744-0.0341673
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0083957
148Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0006163

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