CPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.04678849
2doxorubicin metabolic process (GO:0044598)8.04678849
3daunorubicin metabolic process (GO:0044597)8.04678849
4neutrophil mediated immunity (GO:0002446)7.64587064
5COPI coating of Golgi vesicle (GO:0048205)7.33100963
6Golgi transport vesicle coating (GO:0048200)7.33100963
7aminoglycoside antibiotic metabolic process (GO:0030647)7.19826231
8intestinal absorption (GO:0050892)7.09176487
9arachidonic acid secretion (GO:0050482)7.08809920
10icosanoid secretion (GO:0032309)7.08809920
11sterol catabolic process (GO:0016127)7.08395917
12cholesterol catabolic process (GO:0006707)7.08395917
13phosphatidylinositol acyl-chain remodeling (GO:0036149)6.77112689
14transcytosis (GO:0045056)6.63206809
15phosphatidylserine acyl-chain remodeling (GO:0036150)6.56227068
16peptidyl-proline hydroxylation (GO:0019511)6.47245272
17regulation of keratinocyte differentiation (GO:0045616)6.47007008
18phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.44382264
19regulation of keratinocyte proliferation (GO:0010837)6.33959106
20fatty acid derivative transport (GO:1901571)5.84639523
21icosanoid transport (GO:0071715)5.84639523
22intestinal epithelial cell development (GO:0060576)5.80510507
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.60446076
24myeloid leukocyte mediated immunity (GO:0002444)5.50083672
25innate immune response in mucosa (GO:0002227)5.42265980
26positive regulation of nuclease activity (GO:0032075)5.40209349
27protein hydroxylation (GO:0018126)5.38426913
28endocrine pancreas development (GO:0031018)5.37977912
29proline biosynthetic process (GO:0006561)5.01583087
30regulation of acrosome reaction (GO:0060046)5.00561234
31negative regulation of digestive system process (GO:0060457)4.96699081
32cysteine metabolic process (GO:0006534)4.90765350
33regulation of nuclease activity (GO:0032069)4.90218384
34membrane lipid catabolic process (GO:0046466)4.87863474
35endoplasmic reticulum unfolded protein response (GO:0030968)4.82868687
36acute-phase response (GO:0006953)4.73180061
37ceramide catabolic process (GO:0046514)4.68027607
38regulation of phospholipase A2 activity (GO:0032429)4.66922203
39cellular response to unfolded protein (GO:0034620)4.65542480
40response to endoplasmic reticulum stress (GO:0034976)4.64342112
41phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.61429726
42polarized epithelial cell differentiation (GO:0030859)4.58391798
43phosphatidylserine metabolic process (GO:0006658)4.51684516
44ER-nucleus signaling pathway (GO:0006984)4.46170347
45glycolipid catabolic process (GO:0019377)4.43144400
46mucosal immune response (GO:0002385)4.39800150
47cellular response to topologically incorrect protein (GO:0035967)4.38978700
48digestive system process (GO:0022600)4.37689148
49antibacterial humoral response (GO:0019731)4.36925913
50water-soluble vitamin metabolic process (GO:0006767)4.29415031
51mitochondrial calcium ion transport (GO:0006851)4.23387009
52COPII vesicle coating (GO:0048208)4.22846329
53cholesterol transport (GO:0030301)4.22296520
54sterol transport (GO:0015918)4.22296520
55valine metabolic process (GO:0006573)4.14871146
56protein maturation by protein folding (GO:0022417)4.13045635
57progesterone metabolic process (GO:0042448)4.12650473
58insulin-like growth factor receptor signaling pathway (GO:0048009)4.11172345
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.09341910
60glycoside metabolic process (GO:0016137)4.09088081
61branched-chain amino acid catabolic process (GO:0009083)4.08467672
62antimicrobial humoral response (GO:0019730)4.01995277
63organ or tissue specific immune response (GO:0002251)4.01155446
64phosphatidylcholine acyl-chain remodeling (GO:0036151)4.00210053
65primary alcohol catabolic process (GO:0034310)3.95774686
66cellular response to cadmium ion (GO:0071276)3.88132811
67nucleotide-sugar biosynthetic process (GO:0009226)3.87589604
68regulation of epidermal cell differentiation (GO:0045604)3.87554284
69cellular modified amino acid catabolic process (GO:0042219)3.83362081
70pancreas development (GO:0031016)3.82973182
71maintenance of protein localization in organelle (GO:0072595)3.82474977
72serine family amino acid biosynthetic process (GO:0009070)3.79770862
73phosphatidic acid metabolic process (GO:0046473)3.78789361
74phosphatidic acid biosynthetic process (GO:0006654)3.78789361
75alditol phosphate metabolic process (GO:0052646)3.77865826
76response to unfolded protein (GO:0006986)3.76372999
77phospholipid catabolic process (GO:0009395)3.73647749
78zinc ion transport (GO:0006829)3.72597917
79defense response to Gram-positive bacterium (GO:0050830)3.70422429
804-hydroxyproline metabolic process (GO:0019471)3.69532802
81establishment of apical/basal cell polarity (GO:0035089)3.68200913
82negative regulation of epithelial cell differentiation (GO:0030857)3.66199625
83branched-chain amino acid metabolic process (GO:0009081)3.66138122
84leukotriene metabolic process (GO:0006691)3.63852492
85regulation of triglyceride catabolic process (GO:0010896)3.62468078
86response to topologically incorrect protein (GO:0035966)3.59881636
87positive regulation of wound healing (GO:0090303)3.59203461
88aspartate family amino acid catabolic process (GO:0009068)3.57828591
89homocysteine metabolic process (GO:0050667)3.56747610
90peptidyl-asparagine modification (GO:0018196)3.53907933
91ER overload response (GO:0006983)3.53624923
92protein N-linked glycosylation via asparagine (GO:0018279)3.53282782
93signal peptide processing (GO:0006465)3.51899991
94glutamine metabolic process (GO:0006541)3.51318516
95negative regulation of hormone metabolic process (GO:0032351)3.47813766
96cellular response to zinc ion (GO:0071294)3.45495861
97maintenance of gastrointestinal epithelium (GO:0030277)3.43209844
98steroid catabolic process (GO:0006706)3.37902541
99ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.36783393
100L-serine metabolic process (GO:0006563)3.32207238
101acute inflammatory response (GO:0002526)3.30470443
102vitamin metabolic process (GO:0006766)3.30434317
103retinoid metabolic process (GO:0001523)3.24359365
104retinal metabolic process (GO:0042574)3.22740973
105protein N-linked glycosylation (GO:0006487)3.20818198
106regulation of calcium ion import (GO:0090279)3.15330903
107establishment or maintenance of monopolar cell polarity (GO:0061339)3.13330352
108establishment of monopolar cell polarity (GO:0061162)3.13330352
109vesicle coating (GO:0006901)3.12593629
110proline metabolic process (GO:0006560)3.12213063
111mitochondrion distribution (GO:0048311)3.12172106
112tetrapyrrole metabolic process (GO:0033013)3.11467307
113cellular glucuronidation (GO:0052695)3.10011308
114glutathione derivative metabolic process (GO:1901685)3.08431927
115glutathione derivative biosynthetic process (GO:1901687)3.08431927
116positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.07469937
117diterpenoid metabolic process (GO:0016101)3.06720306
118glucuronate metabolic process (GO:0019585)3.03742990
119uronic acid metabolic process (GO:0006063)3.03742990
120Golgi organization (GO:0007030)3.02779664
121membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.00692750
122phosphatidylglycerol metabolic process (GO:0046471)2.99503591
123negative regulation of mRNA metabolic process (GO:1903312)2.97697386
124regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.97590647
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.96537038
126lung secretory cell differentiation (GO:0061140)2.91297064
127negative regulation of epidermal cell differentiation (GO:0045605)2.90482282
128extracellular matrix disassembly (GO:0022617)2.89927317
129positive regulation of heat generation (GO:0031652)2.89591156
130regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.88387215
131cell proliferation involved in metanephros development (GO:0072203)2.87815037
132cyclooxygenase pathway (GO:0019371)2.86687004
133phototransduction, visible light (GO:0007603)2.85504159
134multicellular organismal catabolic process (GO:0044243)2.85230478
135cell redox homeostasis (GO:0045454)2.84565026
136embryonic foregut morphogenesis (GO:0048617)2.82677898
137leukotriene biosynthetic process (GO:0019370)2.82606658
138negative regulation of Notch signaling pathway (GO:0045746)2.81566527
139glucocorticoid metabolic process (GO:0008211)2.81213041
140retinoic acid receptor signaling pathway (GO:0048384)2.79116160
141sphingolipid catabolic process (GO:0030149)2.78335622
142icosanoid biosynthetic process (GO:0046456)2.77233408
143fatty acid derivative biosynthetic process (GO:1901570)2.77233408
144serine family amino acid metabolic process (GO:0009069)2.76931515
145multicellular organismal metabolic process (GO:0044236)2.76130155
146renal absorption (GO:0070293)2.75151932
147macroautophagy (GO:0016236)2.75059855
148regulation of fever generation (GO:0031620)2.74364601
149L-alpha-amino acid transmembrane transport (GO:1902475)2.74116722
150endothelial cell migration (GO:0043542)2.73933541
151columnar/cuboidal epithelial cell development (GO:0002066)2.72805873
152protein targeting to ER (GO:0045047)2.72717465
153SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.72587301
154creatine metabolic process (GO:0006600)2.72126951
155negative regulation of epidermis development (GO:0045683)2.71976649
156terpenoid metabolic process (GO:0006721)2.71853068
157negative regulation of cell fate commitment (GO:0010454)2.71217573
158C21-steroid hormone metabolic process (GO:0008207)2.67706419
159cotranslational protein targeting to membrane (GO:0006613)2.67300400
160regulation of metalloenzyme activity (GO:0048552)2.65770943
161membrane repolarization during action potential (GO:0086011)2.65208458
162peptidyl-proline modification (GO:0018208)2.63194675
163establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63041074
164regulation of oxidative stress-induced cell death (GO:1903201)2.62966072
165regulation of cardioblast differentiation (GO:0051890)2.62221968
166erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60662150
167L-phenylalanine catabolic process (GO:0006559)2.60662150
168quinone metabolic process (GO:1901661)2.58020827
169cholesterol metabolic process (GO:0008203)2.48352820
170exocrine pancreas development (GO:0031017)17.5343204
171intestinal cholesterol absorption (GO:0030299)16.0980202
172digestion (GO:0007586)13.5363903
173protein retention in ER lumen (GO:0006621)11.4926942
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.0084284
175cobalamin metabolic process (GO:0009235)10.0048018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.53798962
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.16638968
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.83253664
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44954111
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.90819506
6SOX2_27498859_Chip-Seq_STOMACH_Mouse2.88985405
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.68108090
8HTT_18923047_ChIP-ChIP_STHdh_Human2.58683799
9TCF4_18268006_ChIP-ChIP_LS174T_Human2.51997252
10GATA4_25053715_ChIP-Seq_YYC3_Human2.42476895
11GATA6_25053715_ChIP-Seq_YYC3_Human2.41793436
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.40798737
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33055609
14GATA1_22025678_ChIP-Seq_K562_Human2.30588525
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28489992
16CLOCK_20551151_ChIP-Seq_293T_Human2.22296719
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.16163800
18RXR_22158963_ChIP-Seq_LIVER_Mouse2.10864854
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09592025
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97055472
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.94979395
22CHD1_26751641_Chip-Seq_LNCaP_Human1.89500124
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87090530
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.76799517
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.74762037
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71065147
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70775515
28CREB1_26743006_Chip-Seq_LNCaP_Human1.70273501
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70263798
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68222503
31LXR_22292898_ChIP-Seq_THP-1_Human1.66548629
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65891797
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60269018
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55962421
35CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.55075817
36MYC_22102868_ChIP-Seq_BL_Human1.52980633
37PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.50882616
38FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48114686
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.44984406
40RACK7_27058665_Chip-Seq_MCF-7_Human1.44293933
41HNFA_21074721_ChIP-Seq_CACO-2_Human1.44029125
42NANOG_21062744_ChIP-ChIP_HESCs_Human1.42205840
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42153124
44ETV1_20927104_ChIP-Seq_GIST48_Human1.42037086
45PHF8_20622853_ChIP-Seq_HELA_Human1.39604202
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39161121
47NFYA_21822215_ChIP-Seq_K562_Human1.39144270
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39094254
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.38872090
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38498830
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36685247
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36669033
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36505165
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36056010
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.34963199
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.34762261
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34728562
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33566516
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33475818
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.33473272
61* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33431842
62* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32105684
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.31872330
64ATF3_27146783_Chip-Seq_COLON_Human1.31704890
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31419555
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.30669534
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29886765
68CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29607444
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29438041
70RBPJ_21746931_ChIP-Seq_IB4_Human1.27246543
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27126635
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27053774
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26520992
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24883531
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24030446
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23660637
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23638071
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22895576
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.22438326
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.22168393
81CBP_21632823_ChIP-Seq_H3396_Human1.20807628
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20391548
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20312649
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20006073
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18969903
86CDX2_20551321_ChIP-Seq_CACO-2_Human1.18761291
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18451877
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18240498
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17720223
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15468660
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14946922
92NFYB_21822215_ChIP-Seq_K562_Human1.12977422
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.12818321
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.12818321
95TP63_22573176_ChIP-Seq_HFKS_Human1.12405071
96* P68_20966046_ChIP-Seq_HELA_Human1.10102420
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09438130
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09077994
99* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07665119
100P300_19829295_ChIP-Seq_ESCs_Human1.07652608
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.06944630
102KDM2B_26808549_Chip-Seq_K562_Human1.06898556
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.06656801
104IRF8_22096565_ChIP-ChIP_GC-B_Human1.05308296
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05200050
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05081439
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05035914
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05035914
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05035914
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04828198
111CDX2_22108803_ChIP-Seq_LS180_Human1.03400773
112* CJUN_26792858_Chip-Seq_BT549_Human1.02705409
113P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02525970
114CTCF_27219007_Chip-Seq_Bcells_Human1.02053715
115AR_20517297_ChIP-Seq_VCAP_Human1.01478980
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00766065
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00766065
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00764476
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00201584
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.00048885
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99222192
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99101848
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.97636473
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.96866698
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96822012
126FOXP1_21924763_ChIP-Seq_HESCs_Human0.95515199
127SOX2_20726797_ChIP-Seq_SW620_Human0.95334168
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94894395
129EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94470595
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.94379397
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92237610
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92105305
133NANOG_19829295_ChIP-Seq_ESCs_Human0.91933061
134SOX2_19829295_ChIP-Seq_ESCs_Human0.91933061
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91735926
136ZNF274_21170338_ChIP-Seq_K562_Hela0.91671724
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91555079
138TAF15_26573619_Chip-Seq_HEK293_Human0.90705260
139FOXH1_21741376_ChIP-Seq_EPCs_Human0.90677324
140EGR1_19032775_ChIP-ChIP_M12_Human0.90508845
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90461607
142FOXH1_21741376_ChIP-Seq_ESCs_Human0.89485118
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89350273
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88976026
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88339121
146SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88339121
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87664251
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87526342
149TBL1_22424771_ChIP-Seq_293T_Human0.87376382
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.86349122
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.85734738
152FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85734738
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85513959
154* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84038446
155PIAS1_25552417_ChIP-Seq_VCAP_Human0.83762971
156TAF2_19829295_ChIP-Seq_ESCs_Human0.83169323
157* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79424732
158GATA3_21867929_ChIP-Seq_CD8_Mouse0.78851453
159* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78819883
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78444351
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.77669000
162CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75162196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.25766926
2MP0001666_abnormal_nutrient_absorption7.93806519
3MP0005220_abnormal_exocrine_pancreas6.00339820
4MP0003868_abnormal_feces_composition5.32392664
5MP0005365_abnormal_bile_salt5.22365341
6MP0005084_abnormal_gallbladder_morpholo5.04673209
7MP0003122_maternal_imprinting3.48106603
8MP0005085_abnormal_gallbladder_physiolo3.04105782
9MP0010386_abnormal_urinary_bladder3.03390549
10MP0003283_abnormal_digestive_organ2.75170873
11MP0003959_abnormal_lean_body2.53931865
12MP0003123_paternal_imprinting2.43502904
13MP0003705_abnormal_hypodermis_morpholog2.42266897
14MP0004264_abnormal_extraembryonic_tissu2.36695303
15MP0002693_abnormal_pancreas_physiology2.35784415
16MP0001664_abnormal_digestion2.31944592
17MP0010234_abnormal_vibrissa_follicle2.16181889
18MP0001944_abnormal_pancreas_morphology2.15395006
19MP0006054_spinal_hemorrhage2.04430977
20MP0004233_abnormal_muscle_weight1.62652625
21MP0008438_abnormal_cutaneous_collagen1.59801407
22MP0002138_abnormal_hepatobiliary_system1.57253793
23MP0002139_abnormal_hepatobiliary_system1.53195599
24MP0002876_abnormal_thyroid_physiology1.52876326
25MP0003195_calcinosis1.49237098
26MP0002928_abnormal_bile_duct1.39001482
27MP0002132_abnormal_respiratory_system1.38977085
28MP0003252_abnormal_bile_duct1.36882919
29MP0003011_delayed_dark_adaptation1.28443850
30MP0005448_abnormal_energy_balance1.24750131
31MP0003121_genomic_imprinting1.15240183
32MP0003638_abnormal_response/metabolism_1.08099843
33MP0008004_abnormal_stomach_pH1.05286489
34MP0004272_abnormal_basement_membrane1.05148810
35MP0000470_abnormal_stomach_morphology1.04392968
36MP0003119_abnormal_digestive_system1.03016110
37MP0000003_abnormal_adipose_tissue0.99665291
38MP0009384_cardiac_valve_regurgitation0.99404424
39MP0003941_abnormal_skin_development0.96759899
40MP0002909_abnormal_adrenal_gland0.95927326
41MP0002163_abnormal_gland_morphology0.95831258
42MP0002118_abnormal_lipid_homeostasis0.93696341
43MP0001756_abnormal_urination0.93121295
44MP0009672_abnormal_birth_weight0.88363327
45MP0009703_decreased_birth_body0.87807047
46MP0008961_abnormal_basal_metabolism0.86045887
47MP0005408_hypopigmentation0.85950945
48MP0009840_abnormal_foam_cell0.84153097
49MP0002078_abnormal_glucose_homeostasis0.82776246
50MP0000490_abnormal_crypts_of0.78692130
51MP0002938_white_spotting0.77819578
52MP0002277_abnormal_respiratory_mucosa0.76773980
53MP0000537_abnormal_urethra_morphology0.74660394
54MP0010352_gastrointestinal_tract_polyps0.74190330
55MP0003115_abnormal_respiratory_system0.72718377
56MP0000613_abnormal_salivary_gland0.71582148
57MP0004019_abnormal_vitamin_homeostasis0.71428538
58MP0009780_abnormal_chondrocyte_physiolo0.71159022
59MP0005451_abnormal_body_composition0.70539621
60MP0005332_abnormal_amino_acid0.69716139
61MP0003942_abnormal_urinary_system0.66123266
62MP0003567_abnormal_fetal_cardiomyocyte0.65335374
63MP0010329_abnormal_lipoprotein_level0.64891049
64MP0005319_abnormal_enzyme/_coenzyme0.64140264
65MP0005636_abnormal_mineral_homeostasis0.63232632
66MP0005165_increased_susceptibility_to0.60812240
67MP0005379_endocrine/exocrine_gland_phen0.60795996
68MP0001845_abnormal_inflammatory_respons0.59488118
69MP0009643_abnormal_urine_homeostasis0.57794395
70MP0003953_abnormal_hormone_level0.57724599
71MP0002896_abnormal_bone_mineralization0.56981911
72MP0000538_abnormal_urinary_bladder0.56680814
73MP0000013_abnormal_adipose_tissue0.55783356
74MP0002970_abnormal_white_adipose0.53691518
75MP0004197_abnormal_fetal_growth/weight/0.53298912
76MP0005623_abnormal_meninges_morphology0.53002085
77MP0003045_fibrosis0.48398776
78MP0000598_abnormal_liver_morphology0.48251582
79MP0010678_abnormal_skin_adnexa0.47972395
80MP0003656_abnormal_erythrocyte_physiolo0.47740655
81MP0005452_abnormal_adipose_tissue0.47654610
82MP0003943_abnormal_hepatobiliary_system0.46847873
83MP0003950_abnormal_plasma_membrane0.45870814
84MP0008875_abnormal_xenobiotic_pharmacok0.45678884
85MP0009642_abnormal_blood_homeostasis0.45569181
86MP0001731_abnormal_postnatal_growth0.45508399
87MP0005375_adipose_tissue_phenotype0.45064226
88MP0005076_abnormal_cell_differentiation0.44241373
89MP0001873_stomach_inflammation0.43994548
90MP0001765_abnormal_ion_homeostasis0.43552493
91MP0004185_abnormal_adipocyte_glucose0.43048929
92MP0001270_distended_abdomen0.42858902
93MP0000462_abnormal_digestive_system0.42435904
94MP0004043_abnormal_pH_regulation0.42326695
95MP0002060_abnormal_skin_morphology0.42217247
96MP0005187_abnormal_penis_morphology0.41868342
97MP0002098_abnormal_vibrissa_morphology0.41460045
98MP0002089_abnormal_postnatal_growth/wei0.41267768
99MP0000566_synostosis0.40728293
100MP0004147_increased_porphyrin_level0.39693974
101MP0008469_abnormal_protein_level0.38673567
102MP0003866_abnormal_defecation0.38393931
103MP0001340_abnormal_eyelid_morphology0.38358078
104MP0005166_decreased_susceptibility_to0.38342305
105MP0005535_abnormal_body_temperature0.37990831
106MP0003787_abnormal_imprinting0.37127695
107MP0000367_abnormal_coat/_hair0.36642727
108MP0003385_abnormal_body_wall0.35648152
109MP0008872_abnormal_physiological_respon0.35453010
110MP0000534_abnormal_ureter_morphology0.34666812
111MP0002796_impaired_skin_barrier0.34649482
112MP0000377_abnormal_hair_follicle0.34635985
113MP0004858_abnormal_nervous_system0.33942323
114MP0003693_abnormal_embryo_hatching0.32721272
115MP0002136_abnormal_kidney_physiology0.32478801
116MP0000428_abnormal_craniofacial_morphol0.31885105
117MP0004134_abnormal_chest_morphology0.31352304
118MP0003879_abnormal_hair_cell0.31154671
119MP0008995_early_reproductive_senescence0.30875339
120MP0002295_abnormal_pulmonary_circulatio0.30353833
121MP0009763_increased_sensitivity_to0.30326008
122MP0005381_digestive/alimentary_phenotyp0.30192576
123MP0001286_abnormal_eye_development0.28334762
124MP0001502_abnormal_circadian_rhythm0.27929284
125MP0003436_decreased_susceptibility_to0.27910545
126MP0008260_abnormal_autophagy0.27663175
127MP0001849_ear_inflammation0.27489537
128MP0005334_abnormal_fat_pad0.27145314
129MP0003795_abnormal_bone_structure0.26555851
130MP0001348_abnormal_lacrimal_gland0.26536282
131MP0001501_abnormal_sleep_pattern0.25281945
132MP0000609_abnormal_liver_physiology0.25111696
133MP0005410_abnormal_fertilization0.24901585
134MP0005595_abnormal_vascular_smooth0.24866831
135MP0003566_abnormal_cell_adhesion0.24832053
136MP0005058_abnormal_lysosome_morphology0.24152859
137MP0002069_abnormal_eating/drinking_beha0.23862761
138MP0009765_abnormal_xenobiotic_induced0.23772144
139MP0003300_gastrointestinal_ulcer0.23293866
140MP0002697_abnormal_eye_size0.23209204
141MP0002168_other_aberrant_phenotype0.23124664
142MP0001663_abnormal_digestive_system0.23096229
143MP0004484_altered_response_of0.22484018
144MP0001485_abnormal_pinna_reflex0.21660091
145MP0003186_abnormal_redox_activity0.20512397
146MP0003956_abnormal_body_size0.18542993
147MP0005360_urolithiasis0.17710428
148MP0002822_catalepsy0.16944828
149MP0000858_altered_metastatic_potential0.16237370

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.17788064
2Fat malabsorption (HP:0002630)5.94433250
3Exocrine pancreatic insufficiency (HP:0001738)5.54357417
4Abnormal pancreas size (HP:0012094)5.49586344
5Gout (HP:0001997)5.29598212
6Abnormality of the pancreatic islet cells (HP:0006476)5.20685028
7Abnormality of endocrine pancreas physiology (HP:0012093)5.20685028
8Decreased subcutaneous fat (HP:0001002)4.85728898
9Short chin (HP:0000331)4.82368978
10Hypoproteinemia (HP:0003075)4.61959283
11Abnormality of subcutaneous fat tissue (HP:0001001)4.51014622
12Type I diabetes mellitus (HP:0100651)4.27664401
13Tetraparesis (HP:0002273)4.12797811
14Maternal diabetes (HP:0009800)3.92960552
15Ketoacidosis (HP:0001993)3.82753333
16Abnormality of the intrinsic pathway (HP:0010989)3.72746737
17Late onset (HP:0003584)3.58848671
18Asymmetry of the thorax (HP:0001555)3.32711135
19Hypoplasia of the pons (HP:0012110)3.30668004
20Pancreatitis (HP:0001733)3.18344482
21Absent eyelashes (HP:0000561)3.17633349
22Ketosis (HP:0001946)3.17153755
23Vascular calcification (HP:0004934)3.16512010
24Hypotension (HP:0002615)3.11720855
25Abnormality of the pons (HP:0007361)3.01508877
26Hepatoblastoma (HP:0002884)2.96226940
27Joint stiffness (HP:0001387)2.94423985
28Pancreatic islet-cell hyperplasia (HP:0004510)2.91723550
29Anal atresia (HP:0002023)2.90493216
30Lymphangioma (HP:0100764)2.88021648
31Abnormality of proline metabolism (HP:0010907)2.86668915
32Hydroxyprolinuria (HP:0003080)2.86668915
33Tubulointerstitial fibrosis (HP:0005576)2.82382535
34Cardiovascular calcification (HP:0011915)2.80439445
35Rectal prolapse (HP:0002035)2.77769402
36Hypoglycemic coma (HP:0001325)2.76347541
37Enlarged penis (HP:0000040)2.72190382
38Ankyloglossia (HP:0010296)2.65211307
39Hypoglycemic seizures (HP:0002173)2.61875621
40Hyperinsulinemic hypoglycemia (HP:0000825)2.58342493
41Abnormal sex determination (HP:0012244)2.55791909
42Sex reversal (HP:0012245)2.55791909
43Abnormality of dentin (HP:0010299)2.53294858
44Premature skin wrinkling (HP:0100678)2.51398277
45Type I transferrin isoform profile (HP:0003642)2.51360799
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.51355679
47Reduced antithrombin III activity (HP:0001976)2.44060549
48Cortical dysplasia (HP:0002539)2.42957465
49Congenital glaucoma (HP:0001087)2.42057758
50Abnormality of the common coagulation pathway (HP:0010990)2.40526157
51Tubulointerstitial nephritis (HP:0001970)2.38510691
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.38359347
53Ventricular fibrillation (HP:0001663)2.36526715
54Hyperglycemia (HP:0003074)2.36388395
55Germ cell neoplasia (HP:0100728)2.32276860
56Large for gestational age (HP:0001520)2.32092144
57Male infertility (HP:0003251)2.31147984
58Tubular atrophy (HP:0000092)2.29210606
59Fragile skin (HP:0001030)2.26458409
60Atrophic scars (HP:0001075)2.23881196
61Pectus carinatum (HP:0000768)2.22980772
62Ileus (HP:0002595)2.19852310
63Right ventricular cardiomyopathy (HP:0011663)2.18577270
64Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.17906569
65Esophageal varix (HP:0002040)2.17546736
66Carpal bone hypoplasia (HP:0001498)2.16190155
67Fatigue (HP:0012378)2.12267451
68Renal duplication (HP:0000075)2.11163797
69Increased purine levels (HP:0004368)2.10941882
70Hyperuricemia (HP:0002149)2.10941882
71Testicular neoplasm (HP:0010788)2.10297583
72Abnormal protein glycosylation (HP:0012346)2.06792930
73Abnormal glycosylation (HP:0012345)2.06792930
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06792930
75Abnormal protein N-linked glycosylation (HP:0012347)2.06792930
76Abnormality of methionine metabolism (HP:0010901)2.04472114
77Prenatal maternal abnormality (HP:0002686)2.02677157
78Diastasis recti (HP:0001540)2.01466165
79Paraparesis (HP:0002385)2.01258481
80Thin bony cortex (HP:0002753)1.99197594
81Insulin resistance (HP:0000855)1.98539127
82Macroorchidism (HP:0000053)1.96673738
83Optic nerve hypoplasia (HP:0000609)1.96499355
84Patent foramen ovale (HP:0001655)1.94428717
85Enlarged kidneys (HP:0000105)1.92824289
86Abnormal biliary tract morphology (HP:0012440)1.92231172
87Micronodular cirrhosis (HP:0001413)1.89561098
88Buphthalmos (HP:0000557)1.87988854
89Hyperphosphatemia (HP:0002905)1.87861825
90Subacute progressive viral hepatitis (HP:0006572)1.87113090
91Insulin-resistant diabetes mellitus (HP:0000831)1.87092644
92Long foot (HP:0001833)1.86405852
93Villous atrophy (HP:0011473)1.85420441
94Abnormality of small intestinal villus morphology (HP:0011472)1.85420441
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84773004
96Thoracolumbar scoliosis (HP:0002944)1.84758485
97Stenosis of the external auditory canal (HP:0000402)1.83504870
98Abnormality of oral frenula (HP:0000190)1.81250679
99Small epiphyses (HP:0010585)1.79935197
100Unilateral renal agenesis (HP:0000122)1.79863980
101Abdominal pain (HP:0002027)1.78018978
102Abnormal tarsal ossification (HP:0008369)1.76475732
103Abnormality of sulfur amino acid metabolism (HP:0004339)1.75700841
104Mitral valve prolapse (HP:0001634)1.75473474
105Hyperglycinemia (HP:0002154)1.75472000
106Large hands (HP:0001176)1.75173483
107Periodontitis (HP:0000704)1.74554640
108Abnormality of the pleura (HP:0002103)1.73740632
109Popliteal pterygium (HP:0009756)1.73514107
110Congenital malformation of the right heart (HP:0011723)1.73341710
111Double outlet right ventricle (HP:0001719)1.73341710
112Blue sclerae (HP:0000592)1.72381333
113Lower limb hyperreflexia (HP:0002395)1.70774806
114Malnutrition (HP:0004395)1.70421919
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70201356
116Infantile muscular hypotonia (HP:0008947)1.70174030
117Wormian bones (HP:0002645)1.69727753
118Biconcave vertebral bodies (HP:0004586)1.68608319
119Neonatal respiratory distress (HP:0002643)1.68080608
120Prolonged QT interval (HP:0001657)1.68065211
121Epiphyseal dysplasia (HP:0002656)1.67999737
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67924260
123Slender long bone (HP:0003100)1.67623694
124Ankle contracture (HP:0006466)1.67155218
125Severe short stature (HP:0003510)1.65790297
126Hypoplasia of the odontoid process (HP:0003311)1.64667704
127Symptomatic seizures (HP:0011145)1.64425425
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63180328
129Periauricular skin pits (HP:0100277)1.62352464
130Preauricular pit (HP:0004467)1.62352464
131Neoplasm of the pancreas (HP:0002894)1.62221947
132Progressive muscle weakness (HP:0003323)1.59691616
133Cerebral aneurysm (HP:0004944)1.59455378
134Abnormality of vitamin metabolism (HP:0100508)1.57523562
135Methylmalonic acidemia (HP:0002912)1.56478240
136Abnormality of vitamin B metabolism (HP:0004340)1.56384303
137Pterygium (HP:0001059)1.55325889
138Autoamputation (HP:0001218)1.55269162
139Abnormality of the vitamin B12 metabolism (HP:0004341)1.52255427
140Vertebral compression fractures (HP:0002953)1.51797358
141Hyperammonemia (HP:0001987)1.51738591
142Increased CSF protein (HP:0002922)1.51538214
143Glossoptosis (HP:0000162)1.48457952
144Vacuolated lymphocytes (HP:0001922)1.46950409
145Goiter (HP:0000853)1.46945687
146Abnormal cartilage morphology (HP:0002763)1.42586188
147Azoospermia (HP:0000027)1.38942949
148Glycosuria (HP:0003076)1.37668523
149Abnormality of urine glucose concentration (HP:0011016)1.37668523
150Abnormality of fatty-acid metabolism (HP:0004359)1.37017160
151Abnormal hemoglobin (HP:0011902)1.36860966
152Glomerulonephritis (HP:0000099)1.32843799
153Congenital, generalized hypertrichosis (HP:0004540)1.31337828
154Bifid uvula (HP:0000193)1.23660546
155Mitral stenosis (HP:0001718)1.15701861
156Abnormality of the nasal septum (HP:0000419)1.15367725
157Abnormality of the right ventricle (HP:0001707)1.15336483
158Methylmalonic aciduria (HP:0012120)1.15239612
159Spastic paraparesis (HP:0002313)1.13674600
160Epiphyseal stippling (HP:0010655)1.13239072
161Tubulointerstitial abnormality (HP:0001969)1.12851178
162Renal tubular acidosis (HP:0001947)1.10028278
163Rhabdomyolysis (HP:0003201)1.09481179
164Type II lissencephaly (HP:0007260)1.07929524
165Dicarboxylic aciduria (HP:0003215)1.07710322
166Abnormality of dicarboxylic acid metabolism (HP:0010995)1.07710322
167Sparse eyelashes (HP:0000653)1.06738514
168Increased circulating renin level (HP:0000848)1.06667314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.05432844
2PKN25.45289305
3TRIB35.34832902
4ERN14.28454441
5EPHA23.96566916
6EIF2AK33.50472105
7MAP2K23.30253042
8MAP3K33.21055155
9MAP3K123.06707139
10EIF2AK12.56732897
11LATS12.50443904
12STK162.26978792
13PTK62.26264478
14FRK2.19753322
15GRK12.17966559
16INSRR2.14785533
17MST41.97661918
18NEK61.95574286
19EEF2K1.90465386
20TAOK31.88418143
21SCYL21.87025695
22PAK21.79391628
23PASK1.78586322
24RPS6KB21.78465376
25FLT31.70960503
26RIPK11.69481447
27MAP3K101.64335988
28PDGFRA1.56815597
29OXSR11.50709500
30ZAP701.48256664
31PRKG21.44113408
32TBK11.39805172
33MAPK151.37429579
34PDGFRB1.36147908
35BMPR1B1.35736596
36WNK41.34287085
37MAP2K11.33021504
38ERBB41.32795958
39LRRK21.32073097
40STK241.27154636
41NLK1.25786183
42STK38L1.19160523
43PRKD31.17034713
44MAP3K21.16905906
45CAMKK11.15708994
46MYLK1.07976741
47IRAK11.05461112
48MTOR1.04527328
49NTRK31.02081693
50RET1.00332719
51PIK3CG0.94088592
52FER0.93652179
53PTK20.92826698
54MAPKAPK30.91090084
55ERBB30.88671486
56ILK0.86967365
57PAK40.86579082
58PIM20.86281011
59SIK10.84595640
60CDK190.84400441
61IRAK30.84063583
62MET0.83366366
63TESK10.81793292
64DDR20.81153714
65CDK80.80200984
66NME20.76945992
67ACVR1B0.75935338
68PRKCE0.75416989
69NME10.74448745
70FGFR40.73612103
71IRAK20.70076298
72DYRK1B0.70036774
73DAPK10.67726142
74NTRK10.67188686
75PRKCI0.64287581
76TRPM70.64187369
77DYRK1A0.63453313
78MAP3K140.62099287
79MAP3K50.61299880
80PRKCH0.59384653
81PIK3CA0.58832702
82EPHA30.57872945
83DAPK20.57696300
84KSR20.57662779
85NEK10.56709914
86CDK40.54359922
87SRPK10.54177840
88TAOK20.53190417
89ERBB20.52567967
90ROCK10.47885117
91MAP3K10.45508095
92BCR0.45490354
93HIPK20.45350542
94MAPK70.45314818
95FGFR10.42510684
96MAP3K80.41858763
97JAK10.41740210
98BMPR20.38793979
99WNK10.36957211
100PRKCZ0.36893563
101MAP3K70.36431318
102STK30.36234662
103CSNK1E0.35757625
104BRSK20.35094156
105PRKCQ0.34913295
106CASK0.34357429
107PRKD10.34291890
108STK390.33840473
109PRKACB0.33067914
110STK380.32719854
111FGFR30.32583743
112TSSK60.32077520
113MAPK30.31994216
114MAPK10.30898408
115RPS6KA10.30099213
116PDPK10.28246704
117MAP4K20.27662501
118DAPK30.27301535
119RPS6KB10.25475620
120YES10.25148469
121MELK0.25143145
122AKT10.24746793
123SGK30.24456708
124LMTK20.24234307
125TGFBR20.23168829
126LATS20.22966041
127EPHB10.21954111
128GSK3A0.21624958
129TRIM280.21581586
130SGK20.21159342
131PRKAA10.20268068
132TIE10.20108726
133IGF1R0.19993072
134AKT20.19545421
135EIF2AK20.19296960
136PRKCA0.19265858
137MUSK0.18981350
138PDK10.18963406
139UHMK10.18932024
140TYRO30.18695344
141CSNK1A1L0.18635405
142MAPK120.18490070
143PAK30.17792474
144MAPK90.17299443
145LIMK10.17169012
146PRKD20.16728718
147ICK0.14979606
148PRKDC0.14935612
149NUAK10.14261723
150JAK20.14098700
151SGK2230.14044574
152SGK4940.14044574
153NEK90.13839988
154CSNK1G10.13572215
155PRKACA0.12623178
156CSNK1G20.12322904
157TAOK10.12178947
158MST1R0.12089107
159PRKACG0.11843054
160PRKCD0.11618066
161PDK20.11596278
162MAPK140.11549671
163CSNK1A10.11236700

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.38378652
2Fat digestion and absorption_Homo sapiens_hsa049756.58082746
3* Protein digestion and absorption_Homo sapiens_hsa049745.72233710
4Maturity onset diabetes of the young_Homo sapiens_hsa049505.24365233
5Glycerolipid metabolism_Homo sapiens_hsa005613.26326771
6Protein export_Homo sapiens_hsa030603.14041586
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.52223683
8Folate biosynthesis_Homo sapiens_hsa007901.97986449
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89565723
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.74368584
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71754904
12Steroid biosynthesis_Homo sapiens_hsa001001.67205489
13N-Glycan biosynthesis_Homo sapiens_hsa005101.28168604
14Ether lipid metabolism_Homo sapiens_hsa005651.26532779
15Notch signaling pathway_Homo sapiens_hsa043301.25549047
16Propanoate metabolism_Homo sapiens_hsa006401.19543946
17Arachidonic acid metabolism_Homo sapiens_hsa005901.17650378
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15377001
19Vitamin digestion and absorption_Homo sapiens_hsa049771.14112179
20Insulin secretion_Homo sapiens_hsa049111.07343552
21Renin-angiotensin system_Homo sapiens_hsa046141.06765084
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03372439
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98843512
24Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95379870
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90989975
26Arginine and proline metabolism_Homo sapiens_hsa003300.89043559
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82635824
28Vitamin B6 metabolism_Homo sapiens_hsa007500.82619936
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81345293
30Chemical carcinogenesis_Homo sapiens_hsa052040.77957399
31Starch and sucrose metabolism_Homo sapiens_hsa005000.77850550
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77398485
33Selenocompound metabolism_Homo sapiens_hsa004500.77043774
34Steroid hormone biosynthesis_Homo sapiens_hsa001400.75180922
35Biosynthesis of amino acids_Homo sapiens_hsa012300.74649841
36One carbon pool by folate_Homo sapiens_hsa006700.73888280
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72034653
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69623348
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66758357
40Vibrio cholerae infection_Homo sapiens_hsa051100.66271835
41Influenza A_Homo sapiens_hsa051640.64223795
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61164300
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59106361
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56514908
45Mineral absorption_Homo sapiens_hsa049780.55288005
46Linoleic acid metabolism_Homo sapiens_hsa005910.54747487
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52259083
48Endometrial cancer_Homo sapiens_hsa052130.49416929
49Sulfur metabolism_Homo sapiens_hsa009200.48861552
50Fatty acid degradation_Homo sapiens_hsa000710.47148624
51beta-Alanine metabolism_Homo sapiens_hsa004100.44513032
52Circadian rhythm_Homo sapiens_hsa047100.44198975
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43997050
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.43525982
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43494683
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41863175
57Other glycan degradation_Homo sapiens_hsa005110.40680765
58Retinol metabolism_Homo sapiens_hsa008300.39009619
59Tight junction_Homo sapiens_hsa045300.38360636
60Tryptophan metabolism_Homo sapiens_hsa003800.37669913
61Lysine degradation_Homo sapiens_hsa003100.37623047
62Pyruvate metabolism_Homo sapiens_hsa006200.36601998
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36380085
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35665104
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35558517
66Thyroid cancer_Homo sapiens_hsa052160.33098893
67Sphingolipid metabolism_Homo sapiens_hsa006000.32436090
68Thyroid hormone synthesis_Homo sapiens_hsa049180.31954500
69Estrogen signaling pathway_Homo sapiens_hsa049150.31637164
70Ribosome_Homo sapiens_hsa030100.31356671
71Complement and coagulation cascades_Homo sapiens_hsa046100.30673600
72Bladder cancer_Homo sapiens_hsa052190.30295215
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30039513
74Proteasome_Homo sapiens_hsa030500.29835645
75mTOR signaling pathway_Homo sapiens_hsa041500.28552872
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.28135484
77Adherens junction_Homo sapiens_hsa045200.28127319
78Cocaine addiction_Homo sapiens_hsa050300.26709583
79Legionellosis_Homo sapiens_hsa051340.26354047
80Prostate cancer_Homo sapiens_hsa052150.24808415
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24260436
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24224383
83VEGF signaling pathway_Homo sapiens_hsa043700.23032880
84Insulin resistance_Homo sapiens_hsa049310.22991130
85Butanoate metabolism_Homo sapiens_hsa006500.22396570
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20573411
87Peroxisome_Homo sapiens_hsa041460.19558637
88Nitrogen metabolism_Homo sapiens_hsa009100.19019567
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18870614
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18565404
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17260549
92Hepatitis C_Homo sapiens_hsa051600.16980253
93Galactose metabolism_Homo sapiens_hsa000520.15846251
94Carbon metabolism_Homo sapiens_hsa012000.14926407
95Regulation of autophagy_Homo sapiens_hsa041400.14139485
96Gastric acid secretion_Homo sapiens_hsa049710.13366269
97Histidine metabolism_Homo sapiens_hsa003400.12940241
98Fatty acid elongation_Homo sapiens_hsa000620.12702098
99Hippo signaling pathway_Homo sapiens_hsa043900.12357481
100Fructose and mannose metabolism_Homo sapiens_hsa000510.12289895
101Viral myocarditis_Homo sapiens_hsa054160.11943367
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11818686
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11548235
104Type II diabetes mellitus_Homo sapiens_hsa049300.10959853
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10696356
106Pentose phosphate pathway_Homo sapiens_hsa000300.10524549
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.10207026
108Insulin signaling pathway_Homo sapiens_hsa049100.10128785
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10025241
110Type I diabetes mellitus_Homo sapiens_hsa049400.09605494
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.09161758
112ECM-receptor interaction_Homo sapiens_hsa045120.08937985
113Ovarian steroidogenesis_Homo sapiens_hsa049130.08761889
114Calcium signaling pathway_Homo sapiens_hsa040200.08407892
115Lysosome_Homo sapiens_hsa041420.07874086
116Colorectal cancer_Homo sapiens_hsa052100.07736883
117Non-small cell lung cancer_Homo sapiens_hsa052230.07639423
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07348017
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.07281406
120Glutathione metabolism_Homo sapiens_hsa004800.07152614
121Metabolic pathways_Homo sapiens_hsa011000.06742845
122Pancreatic cancer_Homo sapiens_hsa052120.06430524
123Bile secretion_Homo sapiens_hsa049760.05374312
124Tyrosine metabolism_Homo sapiens_hsa003500.05224086
125Focal adhesion_Homo sapiens_hsa045100.04994589
126Small cell lung cancer_Homo sapiens_hsa052220.04525418
127Collecting duct acid secretion_Homo sapiens_hsa049660.04126561
128Toxoplasmosis_Homo sapiens_hsa051450.04099724
129Cholinergic synapse_Homo sapiens_hsa047250.04055089
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.03856351
131Platelet activation_Homo sapiens_hsa046110.03352434
132Phototransduction_Homo sapiens_hsa047440.03320784
133AMPK signaling pathway_Homo sapiens_hsa041520.02996964
134Glucagon signaling pathway_Homo sapiens_hsa049220.02807596
135Arginine biosynthesis_Homo sapiens_hsa002200.02339105
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01809412
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.00843956
138Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0627938
139ABC transporters_Homo sapiens_hsa02010-0.0356697
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0315063
141TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0234808
142Fatty acid metabolism_Homo sapiens_hsa01212-0.0220940
143Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0159852

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