CPA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of inflammatory response to antigenic stimulus (GO:0002863)9.50298694
2regulation of acute inflammatory response to antigenic stimulus (GO:0002864)9.46464279
3leukotriene biosynthetic process (GO:0019370)9.06904912
4* angiotensin maturation (GO:0002003)9.03574391
5regulation of mast cell degranulation (GO:0043304)8.93395649
6positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)8.89890013
7regulation of mast cell activation involved in immune response (GO:0033006)8.42737023
8positive regulation of regulated secretory pathway (GO:1903307)8.37359374
9tyrosine phosphorylation of STAT protein (GO:0007260)8.09255476
10regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.80986882
11thrombin receptor signaling pathway (GO:0070493)7.63801018
12imidazole-containing compound metabolic process (GO:0052803)7.63398028
13regulation of myeloid leukocyte mediated immunity (GO:0002886)7.10460662
14regulation of leukocyte degranulation (GO:0043300)6.81172498
15regulation of mast cell activation (GO:0033003)6.71959242
16leukotriene metabolic process (GO:0006691)5.72662070
17regulation of regulated secretory pathway (GO:1903305)5.69505949
18regulation of tolerance induction (GO:0002643)5.69299248
19regulation of T cell tolerance induction (GO:0002664)5.65637673
20regulation of megakaryocyte differentiation (GO:0045652)5.52844872
21positive regulation of chemokine secretion (GO:0090197)5.46515446
22mast cell activation involved in immune response (GO:0002279)5.30221427
23mast cell degranulation (GO:0043303)5.30221427
24actin nucleation (GO:0045010)5.23374745
25mast cell activation (GO:0045576)4.79524842
26serotonin metabolic process (GO:0042428)4.75912237
27definitive hemopoiesis (GO:0060216)4.72487154
28regulation of inflammatory response to antigenic stimulus (GO:0002861)4.69585283
29positive regulation of acute inflammatory response (GO:0002675)4.60292673
30monoamine transport (GO:0015844)4.58215431
31negative regulation of erythrocyte differentiation (GO:0045647)4.56609511
32lipoxygenase pathway (GO:0019372)4.55351847
33positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.44919402
34megakaryocyte development (GO:0035855)4.43273944
35cytokine biosynthetic process (GO:0042089)4.41977644
36regulation of chemokine biosynthetic process (GO:0045073)4.31245865
37regulation of T cell cytokine production (GO:0002724)4.30577048
38cytokine metabolic process (GO:0042107)4.29033864
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.26010361
40T cell apoptotic process (GO:0070231)4.20446955
41regulation of chemokine secretion (GO:0090196)4.00460687
42platelet dense granule organization (GO:0060155)3.99242963
43germ cell migration (GO:0008354)3.98604857
44positive regulation of B cell mediated immunity (GO:0002714)3.91146726
45positive regulation of immunoglobulin mediated immune response (GO:0002891)3.91146726
46primary amino compound metabolic process (GO:1901160)3.90395160
47cytokine production involved in immune response (GO:0002367)3.87223640
48neutrophil mediated immunity (GO:0002446)3.85833146
49icosanoid biosynthetic process (GO:0046456)3.85555416
50fatty acid derivative biosynthetic process (GO:1901570)3.85555416
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.74342739
52cellular response to exogenous dsRNA (GO:0071360)3.69866689
53positive regulation of granulocyte differentiation (GO:0030854)3.68343380
54negative regulation of interleukin-8 production (GO:0032717)3.64794206
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.63732590
56negative regulation of growth of symbiont in host (GO:0044130)3.63590647
57negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.63590647
58modulation of growth of symbiont involved in interaction with host (GO:0044144)3.63590647
59regulation of growth of symbiont in host (GO:0044126)3.63590647
60disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.54496801
61killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.54496801
62lymphocyte apoptotic process (GO:0070227)3.53956404
63negative regulation of phagocytosis (GO:0050765)3.53437971
64positive regulation of calcium-mediated signaling (GO:0050850)3.53426662
65mature B cell differentiation involved in immune response (GO:0002313)3.45775982
66positive regulation of macrophage differentiation (GO:0045651)3.43863577
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.42359992
68negative regulation of bone resorption (GO:0045779)3.41226254
69actin filament capping (GO:0051693)3.39457931
70cellular extravasation (GO:0045123)3.36178819
71positive regulation of gamma-delta T cell activation (GO:0046645)3.33167882
72positive regulation of exocytosis (GO:0045921)3.25825269
73regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.22886194
74heparin biosynthetic process (GO:0030210)3.22101804
75heparin metabolic process (GO:0030202)3.22101804
76leukocyte apoptotic process (GO:0071887)3.21531465
77positive regulation of natural killer cell differentiation (GO:0032825)3.17152264
78regulation of B cell differentiation (GO:0045577)3.16562935
79hydrogen peroxide catabolic process (GO:0042744)3.14629520
80positive regulation of B cell differentiation (GO:0045579)3.11937588
81unsaturated fatty acid biosynthetic process (GO:0006636)3.11246310
82regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.10869017
83reactive oxygen species biosynthetic process (GO:1903409)3.10752182
84negative regulation of meiosis (GO:0045835)3.10646365
85positive regulation of erythrocyte differentiation (GO:0045648)3.10596113
86regulation of macrophage differentiation (GO:0045649)3.10164795
87pyrimidine nucleotide catabolic process (GO:0006244)3.07424725
88* peptide hormone processing (GO:0016486)3.05447143
89secretory granule organization (GO:0033363)3.01473768
90immunoglobulin mediated immune response (GO:0016064)3.00045169
91positive regulation of Rho protein signal transduction (GO:0035025)2.98050886
92response to peptidoglycan (GO:0032494)2.95889223
93regulation of B cell mediated immunity (GO:0002712)2.95056310
94bone remodeling (GO:0046849)2.94352265
95mRNA transcription (GO:0009299)2.92642970
96positive regulation of protein import into nucleus, translocation (GO:0033160)2.92635578
97antibacterial humoral response (GO:0019731)2.92564424
98regulation of activated T cell proliferation (GO:0046006)2.91692179
99homeostasis of number of cells within a tissue (GO:0048873)2.88937890
100antimicrobial humoral response (GO:0019730)2.88660241
101regulation of interleukin-8 biosynthetic process (GO:0045414)2.87560893
102deoxyribonucleotide catabolic process (GO:0009264)2.86634807
103catecholamine biosynthetic process (GO:0042423)2.86198972
104catechol-containing compound biosynthetic process (GO:0009713)2.86198972
105peroxisome fission (GO:0016559)2.85878647
106hemoglobin metabolic process (GO:0020027)2.84569992
107leukocyte degranulation (GO:0043299)2.84190064
108pinocytosis (GO:0006907)2.83911151
109regulation of granulocyte differentiation (GO:0030852)2.83782287
110deoxyribose phosphate catabolic process (GO:0046386)2.83373601
111regulation of gamma-delta T cell differentiation (GO:0045586)2.79579922
112mRNA transcription from RNA polymerase II promoter (GO:0042789)2.79033178
113negative regulation of B cell apoptotic process (GO:0002903)2.77976861
114positive regulation of chemokine biosynthetic process (GO:0045080)2.76469404
115indolalkylamine metabolic process (GO:0006586)2.76191615
116myeloid leukocyte mediated immunity (GO:0002444)2.74854117
117lysosome localization (GO:0032418)2.74542761
118regulation of MHC class II biosynthetic process (GO:0045346)2.74108748
119mucosal-associated lymphoid tissue development (GO:0048537)2.73501318
120Peyers patch development (GO:0048541)2.73501318
121regulation of immunoglobulin mediated immune response (GO:0002889)2.73468395
122cellular response to dsRNA (GO:0071359)2.72896069
123regulation of respiratory burst (GO:0060263)2.72845511
124endosome to melanosome transport (GO:0035646)2.72559045
125endosome to pigment granule transport (GO:0043485)2.72559045
126positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.72330450
127regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.72330450
128pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.71980789
129UV protection (GO:0009650)2.71241310
130B cell receptor signaling pathway (GO:0050853)2.70062349
131centriole replication (GO:0007099)2.69534063
132neutrophil activation involved in immune response (GO:0002283)2.69449545
133negative regulation of bone remodeling (GO:0046851)2.68677914
134pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.68272874
135microglial cell activation (GO:0001774)2.68231494
136regulation of B cell receptor signaling pathway (GO:0050855)2.67644074
137regulation of B cell apoptotic process (GO:0002902)2.66871762
138negative regulation of acute inflammatory response (GO:0002674)2.66374395
139negative regulation of bone mineralization (GO:0030502)2.65673431
140innate immune response in mucosa (GO:0002227)2.65475573
141mammary gland alveolus development (GO:0060749)2.65313657
142embryonic hemopoiesis (GO:0035162)2.64475710
143negative regulation of macrophage differentiation (GO:0045650)2.63828969
144regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.63201282
145negative regulation of actin filament depolymerization (GO:0030835)2.62721191
146cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.62625117
147positive regulation of interleukin-8 secretion (GO:2000484)2.59972032
148activation of JUN kinase activity (GO:0007257)2.55783827
149positive regulation of myeloid cell differentiation (GO:0045639)2.54225453
150production of molecular mediator of immune response (GO:0002440)2.54216716
151granulocyte differentiation (GO:0030851)2.52248885
152amine biosynthetic process (GO:0009309)2.51970210
153cellular biogenic amine biosynthetic process (GO:0042401)2.51970210
154histamine secretion (GO:0001821)2.42183101
155regulation of erythrocyte differentiation (GO:0045646)2.40694865
156negative regulation of actin filament polymerization (GO:0030837)2.38440292
157regulation of calcium-mediated signaling (GO:0050848)2.34804363
158lung lobe morphogenesis (GO:0060463)2.33498251
159negative regulation of granulocyte differentiation (GO:0030853)2.32041442
160cellular response to glucose stimulus (GO:0071333)2.31848337
161lymphoid progenitor cell differentiation (GO:0002320)2.30558931
162myeloid cell development (GO:0061515)2.28285245
163negative regulation of tissue remodeling (GO:0034104)2.22017406
164positive regulation of mast cell degranulation (GO:0043306)15.8531101
165positive regulation of mast cell activation involved in immune response (GO:0033008)15.8531101
166regulation of hypersensitivity (GO:0002883)13.9433556
167positive regulation of mast cell activation (GO:0033005)13.1558066
168positive regulation of myeloid leukocyte mediated immunity (GO:0002888)12.8205306
169positive regulation of megakaryocyte differentiation (GO:0045654)12.5165871
170positive regulation of leukocyte degranulation (GO:0043302)11.7340335
171positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)10.8940317
172production of molecular mediator involved in inflammatory response (GO:0002532)10.1267954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human6.16468038
2E2F7_22180533_ChIP-Seq_HELA_Human5.50552061
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.57595739
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.55291488
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.32222577
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86737274
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70462606
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66006814
9* RUNX1_22412390_ChIP-Seq_EML_Mouse2.65388676
10TCF7_22412390_ChIP-Seq_EML_Mouse2.59792128
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55005996
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52569571
13GATA1_19941827_ChIP-Seq_MEL_Mouse2.50604527
14VDR_21846776_ChIP-Seq_THP-1_Human2.41426323
15TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.38977805
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35983850
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.35858697
18EGR1_19032775_ChIP-ChIP_M12_Human2.30175477
19LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.27408259
20MYC_22102868_ChIP-Seq_BL_Human2.11909931
21VDR_24763502_ChIP-Seq_THP-1_Human2.02839555
22BP1_19119308_ChIP-ChIP_Hs578T_Human12.3456622
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95699676
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94645147
25MAF_26560356_Chip-Seq_TH1_Human1.91972264
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82877995
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81871536
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81373020
29SPI1_23547873_ChIP-Seq_NB4_Human1.76961004
30GATA1_22383799_ChIP-Seq_G1ME_Mouse1.76612215
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76541174
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73882014
33GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.71969043
34VDR_24787735_ChIP-Seq_THP-1_Human1.70188766
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69295828
36UTX_26944678_Chip-Seq_JUKART_Human1.69145876
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68446065
38MYB_26560356_Chip-Seq_TH2_Human1.68177071
39* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65989031
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.63905265
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62726680
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60790053
43KDM2B_26808549_Chip-Seq_DND41_Human1.60636595
44* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60428726
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59692119
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58064201
47RUNX_20019798_ChIP-Seq_JUKART_Human1.57742987
48SPI1_23127762_ChIP-Seq_K562_Human1.55937231
49GATA1_19941826_ChIP-Seq_K562_Human1.53591096
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49315041
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46481367
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45802211
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45594027
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42768141
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37744876
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33581911
57MYB_26560356_Chip-Seq_TH1_Human1.33448984
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.33069459
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.28978568
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27588371
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25691112
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25388004
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24177608
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20300830
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20276546
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.18533052
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14830521
68BCL6_27268052_Chip-Seq_Bcells_Human1.13505035
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.12929277
70GATA2_19941826_ChIP-Seq_K562_Human1.11898094
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.11276722
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10638337
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10375483
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09451620
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08008690
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07013884
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05375037
78ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04000219
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02935987
80P300_27268052_Chip-Seq_Bcells_Human1.02815106
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02083778
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01728601
83LXR_22292898_ChIP-Seq_THP-1_Human1.01525743
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01249821
85NCOR1_26117541_ChIP-Seq_K562_Human0.97977457
86GATA1_22025678_ChIP-Seq_K562_Human0.97919032
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97872306
88BCOR_27268052_Chip-Seq_Bcells_Human0.96356192
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93725339
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93126327
91GATA3_26560356_Chip-Seq_TH2_Human0.92752285
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91410597
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91296980
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91114192
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.90030746
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89673014
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89218726
98* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88366211
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86261015
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.85104621
101IRF8_22096565_ChIP-ChIP_GC-B_Human0.84866576
102MAF_26560356_Chip-Seq_TH2_Human0.84561077
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84535885
104FOXP3_21729870_ChIP-Seq_TREG_Human0.82780864
105GATA3_27048872_Chip-Seq_THYMUS_Human0.82462701
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81958703
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81710345
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.80692356
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.80032654
110GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79426982
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78334658
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77990452
113CEBPB_22108803_ChIP-Seq_LS180_Human0.76991023
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76528087
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.76467137
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76442260
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76141645
118GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75333576
119E2F1_21310950_ChIP-Seq_MCF-7_Human0.74686701
120RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71544938
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70804837
122SPI1_20517297_ChIP-Seq_HL60_Human0.70463867
123TP53_16413492_ChIP-PET_HCT116_Human0.70063671
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69811447
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68713211
126PU_27001747_Chip-Seq_BMDM_Mouse0.68122103
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.67214627
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.66979506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.91072777
2MP0000465_gastrointestinal_hemorrhage5.04981835
3MP0004808_abnormal_hematopoietic_stem3.94797303
4MP0005464_abnormal_platelet_physiology3.66785024
5MP0002148_abnormal_hypersensitivity_rea3.33849704
6MP0003436_decreased_susceptibility_to3.06938534
7MP0004147_increased_porphyrin_level2.84074982
8MP0001835_abnormal_antigen_presentation2.69594308
9MP0003300_gastrointestinal_ulcer2.60236002
10MP0003566_abnormal_cell_adhesion2.57186448
11MP0005174_abnormal_tail_pigmentation2.42513776
12MP0001873_stomach_inflammation2.42044974
13MP0004782_abnormal_surfactant_physiolog2.40331651
14MP0003183_abnormal_peptide_metabolism2.37825198
15MP0002396_abnormal_hematopoietic_system2.37099560
16MP0002419_abnormal_innate_immunity2.36848457
17MP0001790_abnormal_immune_system2.35811937
18MP0005387_immune_system_phenotype2.35811937
19MP0009379_abnormal_foot_pigmentation2.34695193
20MP0002420_abnormal_adaptive_immunity2.30088962
21MP0005671_abnormal_response_to2.30012939
22MP0001819_abnormal_immune_cell2.28637272
23* MP0002398_abnormal_bone_marrow2.21258545
24MP0008775_abnormal_heart_ventricle2.19427476
25MP0001800_abnormal_humoral_immune2.13593789
26MP0005000_abnormal_immune_tolerance2.10511351
27MP0005025_abnormal_response_to2.08300857
28MP0002735_abnormal_chemical_nociception2.06610251
29MP0003303_peritoneal_inflammation2.01943773
30MP0002723_abnormal_immune_serum1.92188273
31MP0001188_hyperpigmentation1.91652744
32MP0000343_altered_response_to1.87415253
33MP0004858_abnormal_nervous_system1.85028275
34MP0005058_abnormal_lysosome_morphology1.83126217
35MP0005075_abnormal_melanosome_morpholog1.81928932
36MP0010307_abnormal_tumor_latency1.81446551
37MP0003866_abnormal_defecation1.77052087
38MP0006082_CNS_inflammation1.73243130
39MP0002452_abnormal_antigen_presenting1.72898294
40MP0002971_abnormal_brown_adipose1.71872614
41MP0001545_abnormal_hematopoietic_system1.65978661
42MP0005397_hematopoietic_system_phenotyp1.65978661
43MP0002405_respiratory_system_inflammati1.65636892
44MP0000249_abnormal_blood_vessel1.63329249
45MP0001533_abnormal_skeleton_physiology1.62321816
46* MP0002722_abnormal_immune_system1.61795522
47MP0005646_abnormal_pituitary_gland1.59949401
48MP0008770_decreased_survivor_rate1.59845281
49MP0010329_abnormal_lipoprotein_level1.59669286
50MP0008995_early_reproductive_senescence1.59580381
51MP0004883_abnormal_blood_vessel1.59273202
52MP0009115_abnormal_fat_cell1.56900698
53MP0009333_abnormal_splenocyte_physiolog1.55156983
54* MP0000716_abnormal_immune_system1.54313906
55MP0000516_abnormal_urinary_system1.48756414
56MP0005367_renal/urinary_system_phenotyp1.48756414
57MP0001853_heart_inflammation1.47470884
58* MP0002429_abnormal_blood_cell1.47151380
59MP0005623_abnormal_meninges_morphology1.44978026
60MP0000689_abnormal_spleen_morphology1.44280609
61MP0002009_preneoplasia1.43007254
62MP0004885_abnormal_endolymph1.37037384
63MP0008961_abnormal_basal_metabolism1.32202775
64MP0002166_altered_tumor_susceptibility1.30724795
65MP0010155_abnormal_intestine_physiology1.29609154
66MP0008469_abnormal_protein_level1.29496803
67MP0001845_abnormal_inflammatory_respons1.28754275
68MP0004510_myositis1.28634928
69MP0000681_abnormal_thyroid_gland1.21614670
70MP0005360_urolithiasis1.20185910
71MP0003329_amyloid_beta_deposits1.15567092
72MP0003806_abnormal_nucleotide_metabolis1.15465557
73MP0004264_abnormal_extraembryonic_tissu1.14934112
74MP0000372_irregular_coat_pigmentation1.07734175
75MP0009785_altered_susceptibility_to1.07351601
76MP0004185_abnormal_adipocyte_glucose1.07057989
77MP0004947_skin_inflammation1.05667307
78MP0010352_gastrointestinal_tract_polyps1.05596422
79MP0005584_abnormal_enzyme/coenzyme_acti1.05421190
80MP0003172_abnormal_lysosome_physiology1.05347416
81MP0009278_abnormal_bone_marrow1.04406544
82MP0005310_abnormal_salivary_gland1.03883969
83MP0001851_eye_inflammation1.03611694
84MP0000685_abnormal_immune_system1.01964395
85MP0002796_impaired_skin_barrier0.95299424
86MP0000490_abnormal_crypts_of0.92602153
87MP0002938_white_spotting0.91986227
88MP0005448_abnormal_energy_balance0.91222979
89MP0009764_decreased_sensitivity_to0.88941755
90MP0003828_pulmonary_edema0.88084760
91MP0002837_dystrophic_cardiac_calcinosis0.88047156
92MP0005319_abnormal_enzyme/_coenzyme0.87840541
93MP0005164_abnormal_response_to0.87303471
94MP0009643_abnormal_urine_homeostasis0.87165447
95MP0002006_tumorigenesis0.84950773
96MP0003191_abnormal_cellular_cholesterol0.84573897
97MP0005666_abnormal_adipose_tissue0.84502068
98MP0005503_abnormal_tendon_morphology0.83573280
99MP0002970_abnormal_white_adipose0.83518179
100MP0005390_skeleton_phenotype0.82806809
101MP0005166_decreased_susceptibility_to0.81627681
102MP0001881_abnormal_mammary_gland0.80282495
103MP0003656_abnormal_erythrocyte_physiolo0.79306197
104MP0001764_abnormal_homeostasis0.78648985
105MP0003795_abnormal_bone_structure0.78369607
106MP0002909_abnormal_adrenal_gland0.77982013
107MP0001970_abnormal_pain_threshold0.77036586
108MP0000604_amyloidosis0.76972133
109MP0003763_abnormal_thymus_physiology0.76852715
110MP0006036_abnormal_mitochondrial_physio0.76716829
111MP0002998_abnormal_bone_remodeling0.76175150
112MP0009840_abnormal_foam_cell0.75839385
113MP0001666_abnormal_nutrient_absorption0.75149819
114* MP0000703_abnormal_thymus_morphology0.74510828
115MP0002095_abnormal_skin_pigmentation0.73543703
116MP0005535_abnormal_body_temperature0.71606673
117MP0001542_abnormal_bone_strength0.70194898
118MP0002254_reproductive_system_inflammat0.69537603
119MP0008057_abnormal_DNA_replication0.69136778
120MP0000858_altered_metastatic_potential0.69118130
121MP0008874_decreased_physiological_sensi0.69115201
122MP0003724_increased_susceptibility_to0.66578672
123MP0001663_abnormal_digestive_system0.65333205
124* MP0003638_abnormal_response/metabolism_0.65080770
125* MP0009765_abnormal_xenobiotic_induced0.64864615
126MP0006054_spinal_hemorrhage0.64267654
127* MP0009763_increased_sensitivity_to0.62004593
128* MP0008873_increased_physiological_sensi0.61542352
129MP0002128_abnormal_blood_circulation0.59441025
130MP0001727_abnormal_embryo_implantation0.57100619
131MP0005334_abnormal_fat_pad0.54543930
132MP0005076_abnormal_cell_differentiation0.52977097
133MP0001915_intracranial_hemorrhage0.51976302
134MP0002019_abnormal_tumor_incidence0.51813613
135MP0002733_abnormal_thermal_nociception0.51442809

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.79559864
2Abnormal platelet volume (HP:0011876)9.55038473
3Purpura (HP:0000979)9.08845644
4Prolonged bleeding time (HP:0003010)8.96548231
5Menorrhagia (HP:0000132)8.79495842
6Abnormal platelet function (HP:0011869)8.37620412
7Impaired platelet aggregation (HP:0003540)8.37620412
8Gingival bleeding (HP:0000225)7.64946323
9Aplastic anemia (HP:0001915)5.19365709
10Acute lymphatic leukemia (HP:0006721)4.82696462
11Elevated erythrocyte sedimentation rate (HP:0003565)4.82373355
12Agammaglobulinemia (HP:0004432)4.79650358
13Epistaxis (HP:0000421)4.72956910
14Papilledema (HP:0001085)4.34482379
15Autoimmune thrombocytopenia (HP:0001973)4.15306201
16Eczematoid dermatitis (HP:0000976)3.93976607
17Granulocytopenia (HP:0001913)3.73266725
18Abnormality of T cell physiology (HP:0011840)3.57005336
19Esophageal neoplasm (HP:0100751)3.52390711
20Neoplasm of head and neck (HP:0012288)3.52390711
21White forelock (HP:0002211)3.51135513
22Autoimmune hemolytic anemia (HP:0001890)3.36748948
23Cellulitis (HP:0100658)3.30768880
24Chronic otitis media (HP:0000389)3.29351181
25Chronic obstructive pulmonary disease (HP:0006510)3.28896104
26Obstructive lung disease (HP:0006536)3.28896104
27Chronic mucocutaneous candidiasis (HP:0002728)3.27102959
28Recurrent cutaneous fungal infections (HP:0011370)3.27102959
29Heterochromia iridis (HP:0001100)3.16436373
30Patchy hypopigmentation of hair (HP:0011365)3.12870569
31Bruising susceptibility (HP:0000978)3.11615221
32Recurrent viral infections (HP:0004429)3.05449161
33Increased IgE level (HP:0003212)3.05193869
34Meningitis (HP:0001287)3.01505742
35Male infertility (HP:0003251)2.98579967
36Abnormality of B cell number (HP:0010975)2.96680986
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95841933
38Interstitial pulmonary disease (HP:0006530)2.94073331
39Alveolar cell carcinoma (HP:0006519)2.91749519
40Hypergammaglobulinemia (HP:0010702)2.89920747
41Myositis (HP:0100614)2.87163527
42Failure to thrive in infancy (HP:0001531)2.86614626
43Recurrent bacterial skin infections (HP:0005406)2.82012956
44Poikilocytosis (HP:0004447)2.81528222
45Systemic lupus erythematosus (HP:0002725)2.80770518
46Eosinophilia (HP:0001880)2.79122973
47Acute myeloid leukemia (HP:0004808)2.78388798
48Diplopia (HP:0000651)2.74922524
49Abnormality of binocular vision (HP:0011514)2.74922524
50Neoplasm of the peripheral nervous system (HP:0100007)2.69918783
51Neoplasm of the tracheobronchial system (HP:0100552)2.69339095
52Osteomyelitis (HP:0002754)2.64987099
53Periodontitis (HP:0000704)2.63593182
54Abnormality of oral frenula (HP:0000190)2.60614941
55Recurrent fungal infections (HP:0002841)2.56035089
56B lymphocytopenia (HP:0010976)2.55454674
57Recurrent abscess formation (HP:0002722)2.51866259
58IgM deficiency (HP:0002850)2.50840001
59Abnormality of T cells (HP:0002843)2.47437861
60Abnormality of macrophages (HP:0004311)2.45316151
61Gastrointestinal stroma tumor (HP:0100723)2.44567374
62Vasculitis (HP:0002633)2.41634279
63Skin rash (HP:0000988)2.37730588
64Dysostosis multiplex (HP:0000943)2.37481003
65Neutropenia (HP:0001875)2.30175707
66Skin ulcer (HP:0200042)2.26926713
67Recurrent sinusitis (HP:0011108)2.26497504
68Neurodegeneration (HP:0002180)2.24608344
69Chronic diarrhea (HP:0002028)2.23841598
70Recurrent gram-negative bacterial infections (HP:0005420)2.20218619
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.20212357
72Prostate neoplasm (HP:0100787)2.17362576
73Abnormal sex determination (HP:0012244)2.14473834
74Sex reversal (HP:0012245)2.14473834
75Slender build (HP:0001533)2.14067698
76Increased density of long bones (HP:0006392)2.13393761
77Sepsis (HP:0100806)2.11771917
78Hyperacusis (HP:0010780)2.09692990
79Cutaneous melanoma (HP:0012056)2.09075935
80Urticaria (HP:0001025)2.08102006
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06783907
82Dicarboxylic aciduria (HP:0003215)2.06783907
83Cerebral palsy (HP:0100021)2.04379037
84Pustule (HP:0200039)2.03157224
85Recurrent lower respiratory tract infections (HP:0002783)2.01891728
86Episodic fever (HP:0001954)2.01523658
87Gastrointestinal infarctions (HP:0005244)2.00781226
88Petechiae (HP:0000967)12.7543956
89Abnormality of small intestinal villus morphology (HP:0011472)1.99719270
90Villous atrophy (HP:0011473)1.99719270
91Germ cell neoplasia (HP:0100728)1.99618491
92Gingivitis (HP:0000230)1.98605290
93Abnormality of male internal genitalia (HP:0000022)1.97743415
94Thrombocytosis (HP:0001894)1.95819886
95Abnormality of eosinophils (HP:0001879)1.95710299
96Seborrheic dermatitis (HP:0001051)1.95024789
97Pulmonary fibrosis (HP:0002206)1.93524600
98Complement deficiency (HP:0004431)1.93385740
99Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92399069
100Abnormality of complement system (HP:0005339)1.91984008
101Type I transferrin isoform profile (HP:0003642)1.91323497
102Growth hormone excess (HP:0000845)1.90658067
103Insomnia (HP:0100785)1.89952694
104Stomatitis (HP:0010280)1.89465226
105Albinism (HP:0001022)1.88089259
106Abnormality of transition element cation homeostasis (HP:0011030)1.85788463
107Myelodysplasia (HP:0002863)1.85125236
108Hemoptysis (HP:0002105)1.85013280
109Abnormality of the pleura (HP:0002103)1.84287042
110Gonadal dysgenesis (HP:0000133)1.83869919
111Acute hepatic failure (HP:0006554)1.83778413
112Urinary glycosaminoglycan excretion (HP:0003541)1.81851666
113Mucopolysacchariduria (HP:0008155)1.81851666
114Pulmonary infiltrates (HP:0002113)1.81712593
115Increased neuronal autofluorescent lipopigment (HP:0002074)1.80836206
116Large hands (HP:0001176)1.80549674
117Leukocytosis (HP:0001974)1.79396737
118Hepatosplenomegaly (HP:0001433)1.78397244
119Recurrent skin infections (HP:0001581)1.77076866
120Nasal polyposis (HP:0100582)1.75146933
121Cervical subluxation (HP:0003308)1.73518325
122Hematochezia (HP:0002573)1.72031410
123Abnormality of the prostate (HP:0008775)1.71843232
124Cerebral aneurysm (HP:0004944)1.71167248
125Inflammation of the large intestine (HP:0002037)1.71108083
126Spontaneous hematomas (HP:0007420)1.70619726
127Gastrointestinal inflammation (HP:0004386)1.68543492
128Neoplasm of the rectum (HP:0100743)1.67168225
129Increased cerebral lipofuscin (HP:0011813)1.66498354
130Fibroma (HP:0010614)1.61247491
131Fibrous tissue neoplasm (HP:0012316)1.57677101
132Abnormality of polysaccharide metabolism (HP:0011012)1.56341733
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56341733
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.56341733
135Acrocyanosis (HP:0001063)1.54569236
136Severe short stature (HP:0003510)1.53705119
137Abnormality of the lumbar spine (HP:0100712)1.52417932
138Disproportionate tall stature (HP:0001519)1.50832266
139Depressed nasal tip (HP:0000437)1.50060917
140Neoplasm of the small intestine (HP:0100833)1.48201344
141Apathy (HP:0000741)1.47390696
142Erythema (HP:0010783)1.46735374
143Easy fatigability (HP:0003388)1.44754227
144Chest pain (HP:0100749)1.43303919
145Abnormality of the nasal mucosa (HP:0000433)1.42531221
146Supranuclear gaze palsy (HP:0000605)1.42459767
147Abnormality of lateral ventricle (HP:0030047)1.42286133
148Synophrys (HP:0000664)1.41658618
149Amyotrophic lateral sclerosis (HP:0007354)1.40540433
150Diminished motivation (HP:0000745)1.38333639
151Panhypogammaglobulinemia (HP:0003139)1.38324228
152Encephalitis (HP:0002383)1.37140095
153Broad palm (HP:0001169)1.36435325
154Lymphedema (HP:0001004)1.35507188
155Bilateral sensorineural hearing impairment (HP:0008619)1.35228996
156Arterial thrombosis (HP:0004420)1.34325036
157Pallor (HP:0000980)1.32028464
158Colitis (HP:0002583)1.31340522
159Sudden cardiac death (HP:0001645)1.26855692
160Mediastinal lymphadenopathy (HP:0100721)1.26739242
161Trigonocephaly (HP:0000243)1.26526809
162Vacuolated lymphocytes (HP:0001922)1.24922274
163Beaking of vertebral bodies (HP:0004568)1.23519523
164Ankyloglossia (HP:0010296)1.23343999
165Abnormal delayed hypersensitivity skin test (HP:0002963)1.22794158
166Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.22104804
167Viral hepatitis (HP:0006562)1.20917058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT6.68508950
2EEF2K5.53069030
3MATK4.48431386
4TRIM284.01006390
5MAP4K13.45889248
6BCKDK3.19923800
7ERN13.14579311
8TXK2.82547042
9FLT32.66846710
10RIPK42.59669959
11MAPKAPK32.55902687
12FES2.48384755
13PIM22.37658485
14BMPR22.33751798
15PRPF4B2.24959833
16MAPKAPK52.23276142
17CDK62.21626487
18TAOK31.99505154
19NTRK21.92178199
20CSF1R1.86146847
21TRIB31.80282781
22TRPM71.73684029
23RPS6KB21.70294807
24ITK1.65262350
25SCYL21.63898827
26ZAP701.53349887
27SYK1.52629124
28IKBKE1.43176296
29FGFR21.33905445
30NME11.32091549
31MAPKAPK21.31216006
32GRK61.30915950
33BTK1.29439847
34NME21.27667185
35JAK21.23311128
36TGFBR21.18516030
37TYK21.18428265
38LYN1.18032740
39PKN21.16768550
40MAP3K141.16706882
41PDK21.16487232
42ABL21.13791079
43TEC1.11891593
44MAP2K21.10777220
45FER1.10031427
46NEK91.08642139
47LRRK21.06476519
48IRAK41.06198937
49IKBKB1.05740291
50STK101.05258995
51MAP3K121.03493560
52PIM11.02770446
53ACVR1B1.00752341
54SIK20.99596215
55CDC70.97452445
56CSNK1G30.94899929
57TAOK10.92351662
58FGFR30.90749788
59FGFR40.89770137
60MAP3K10.86326832
61PTK60.86228954
62MARK30.83367346
63NUAK10.82109993
64TNIK0.81753908
65CDK40.81174989
66ALK0.80266938
67PRKACG0.78090314
68MUSK0.76617041
69NEK20.74920575
70PRKACB0.73759880
71TIE10.72680376
72PIK3CA0.72462566
73BMX0.72394940
74RPS6KA20.72348343
75BLK0.72203272
76TAOK20.72015853
77GRK70.71991169
78IRAK30.71405859
79MAP2K60.71209474
80EIF2AK30.70731819
81HIPK20.66836739
82MKNK10.66032790
83MAP3K60.65179054
84ERBB30.64051153
85VRK20.63232368
86GSK3A0.63221589
87MAPK110.62603211
88LCK0.62304756
89MAP3K70.61787508
90HCK0.61138312
91CSNK1G20.60762802
92TGFBR10.57468310
93RPS6KC10.56197373
94RPS6KL10.56197373
95RPS6KA40.52603524
96RPS6KA60.51224390
97CSK0.51190765
98PRKD20.50963658
99VRK10.50485407
100CSNK1G10.50475336
101MAP3K130.50045579
102CAMK1G0.49027384
103PAK20.48766298
104TESK20.48655811
105JAK30.48500708
106ABL10.48138756
107KDR0.47592466
108PRKCQ0.47135530
109MAP4K20.46890879
110DAPK20.45934618
111MAP3K110.44842833
112CAMK1D0.43262895
113CAMKK20.42698960
114CDK120.42469039
115PDK10.41996007
116MAPK150.40206471
117EPHB10.38980540
118IRAK10.37194777
119PRKCD0.36083203
120PDPK10.35535406
121PIK3CG0.34836282
122DYRK1B0.34562353
123ILK0.34504927
124RPS6KA50.33685934
125PRKCB0.33679585
126MARK20.33612643
127ATR0.33358542
128MAP3K20.33119659
129CAMKK10.32460168
130WEE10.32423629
131DAPK10.31914181
132STK40.31749168
133CDK190.31492738
134SIK10.31464979
135MOS0.31212647
136TNK20.30954608
137PAK40.30589589
138TBK10.30172050
139MAPK40.29825703
140SRC0.29443213
141MAP3K80.29084594
142UHMK10.28467974
143PDGFRA0.27922389
144MAPK130.27220851
145TYRO30.26385361
146TLK10.25223513
147JAK10.23148356
148MAPK30.21924574
149MAP2K30.21813912
150CLK10.21356198
151FYN0.20977981
152DAPK30.20731812
153MAP2K10.20481815
154CDK70.20453456

Predicted pathways (KEGG)

RankGene SetZ-score
1* Renin-angiotensin system_Homo sapiens_hsa046146.19696234
2Fc epsilon RI signaling pathway_Homo sapiens_hsa046643.82381676
3Histidine metabolism_Homo sapiens_hsa003403.47304172
4Hematopoietic cell lineage_Homo sapiens_hsa046402.38501387
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.13744400
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12304669
7Platelet activation_Homo sapiens_hsa046112.04747245
8Asthma_Homo sapiens_hsa0531010.9141370
9Staphylococcus aureus infection_Homo sapiens_hsa051501.98468835
10Autoimmune thyroid disease_Homo sapiens_hsa053201.82806870
11Tryptophan metabolism_Homo sapiens_hsa003801.82309411
12Ovarian steroidogenesis_Homo sapiens_hsa049131.81508600
13Primary immunodeficiency_Homo sapiens_hsa053401.74566923
14Phospholipase D signaling pathway_Homo sapiens_hsa040721.71695986
15Sphingolipid signaling pathway_Homo sapiens_hsa040711.61115142
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56702203
17B cell receptor signaling pathway_Homo sapiens_hsa046621.44752113
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44203127
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39484069
20Serotonergic synapse_Homo sapiens_hsa047261.38989117
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34067725
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.33920812
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31050357
24Peroxisome_Homo sapiens_hsa041461.30134066
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28296385
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25709002
27Pertussis_Homo sapiens_hsa051331.24191238
28Linoleic acid metabolism_Homo sapiens_hsa005911.22743422
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.18615456
30Antigen processing and presentation_Homo sapiens_hsa046121.18114740
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17992195
32Fat digestion and absorption_Homo sapiens_hsa049751.17865319
33Ribosome_Homo sapiens_hsa030101.17006076
34Toxoplasmosis_Homo sapiens_hsa051451.15650410
35Starch and sucrose metabolism_Homo sapiens_hsa005001.13992174
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.13759991
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13046703
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11990626
39Chronic myeloid leukemia_Homo sapiens_hsa052201.10564028
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09001544
41Nitrogen metabolism_Homo sapiens_hsa009101.08764375
42Type I diabetes mellitus_Homo sapiens_hsa049401.07520919
43Acute myeloid leukemia_Homo sapiens_hsa052211.06666053
44Osteoclast differentiation_Homo sapiens_hsa043801.05492500
45Caffeine metabolism_Homo sapiens_hsa002321.03210129
46Chemical carcinogenesis_Homo sapiens_hsa052041.02022851
47Vitamin digestion and absorption_Homo sapiens_hsa049771.01369936
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.99824608
49Cocaine addiction_Homo sapiens_hsa050300.98332387
50Herpes simplex infection_Homo sapiens_hsa051680.98033876
51DNA replication_Homo sapiens_hsa030300.97697873
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.94227991
53Base excision repair_Homo sapiens_hsa034100.91867674
54Fatty acid degradation_Homo sapiens_hsa000710.91554243
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91307265
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90744890
57ECM-receptor interaction_Homo sapiens_hsa045120.90654513
58Lysosome_Homo sapiens_hsa041420.88683621
59Viral carcinogenesis_Homo sapiens_hsa052030.88011229
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87177779
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.85721196
62Hepatitis B_Homo sapiens_hsa051610.85130732
63Small cell lung cancer_Homo sapiens_hsa052220.84014543
64Influenza A_Homo sapiens_hsa051640.83026108
65Non-small cell lung cancer_Homo sapiens_hsa052230.81913497
66Hepatitis C_Homo sapiens_hsa051600.81891215
67African trypanosomiasis_Homo sapiens_hsa051430.81572002
68p53 signaling pathway_Homo sapiens_hsa041150.81368641
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78036306
70Apoptosis_Homo sapiens_hsa042100.77021680
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73706369
72Malaria_Homo sapiens_hsa051440.71689606
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71367663
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70789623
75Leishmaniasis_Homo sapiens_hsa051400.70788453
76Ether lipid metabolism_Homo sapiens_hsa005650.70721481
77Glutathione metabolism_Homo sapiens_hsa004800.68881530
78Arachidonic acid metabolism_Homo sapiens_hsa005900.66392782
79Rap1 signaling pathway_Homo sapiens_hsa040150.66273593
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66085814
81Arginine biosynthesis_Homo sapiens_hsa002200.65297940
82Retinol metabolism_Homo sapiens_hsa008300.61349171
83Glioma_Homo sapiens_hsa052140.61152460
84N-Glycan biosynthesis_Homo sapiens_hsa005100.56861649
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55715333
86Amphetamine addiction_Homo sapiens_hsa050310.55441345
87Rheumatoid arthritis_Homo sapiens_hsa053230.55260694
88Dilated cardiomyopathy_Homo sapiens_hsa054140.53507869
89Measles_Homo sapiens_hsa051620.53060113
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52255768
91Colorectal cancer_Homo sapiens_hsa052100.51031607
92Legionellosis_Homo sapiens_hsa051340.49668567
93* Pancreatic secretion_Homo sapiens_hsa049720.48890650
94Pancreatic cancer_Homo sapiens_hsa052120.48427617
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47986388
96Homologous recombination_Homo sapiens_hsa034400.46667233
97Galactose metabolism_Homo sapiens_hsa000520.44046714
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44039333
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42857457
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42497682
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41673073
102Pyrimidine metabolism_Homo sapiens_hsa002400.41012768
103VEGF signaling pathway_Homo sapiens_hsa043700.40830765
104Other glycan degradation_Homo sapiens_hsa005110.40184329
105Complement and coagulation cascades_Homo sapiens_hsa046100.39145364
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.39102160
107Glycerolipid metabolism_Homo sapiens_hsa005610.38844939
108Inositol phosphate metabolism_Homo sapiens_hsa005620.38236399
109Alcoholism_Homo sapiens_hsa050340.37102339
110Sphingolipid metabolism_Homo sapiens_hsa006000.36425822
111Pentose phosphate pathway_Homo sapiens_hsa000300.36167351
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35004333
113Phagosome_Homo sapiens_hsa041450.34941012
114Pathways in cancer_Homo sapiens_hsa052000.34042980
115Renin secretion_Homo sapiens_hsa049240.33970672
116Focal adhesion_Homo sapiens_hsa045100.33955945
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32887751
118Salivary secretion_Homo sapiens_hsa049700.32861705
119TNF signaling pathway_Homo sapiens_hsa046680.32317448
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.31992724
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.31960900
122Prion diseases_Homo sapiens_hsa050200.31032776
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30833503
124Viral myocarditis_Homo sapiens_hsa054160.29823629
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29594711
126MicroRNAs in cancer_Homo sapiens_hsa052060.29070644
127Shigellosis_Homo sapiens_hsa051310.28317680
128Endocytosis_Homo sapiens_hsa041440.28044046
129T cell receptor signaling pathway_Homo sapiens_hsa046600.27109638
130Long-term potentiation_Homo sapiens_hsa047200.26987723
131Chemokine signaling pathway_Homo sapiens_hsa040620.26441881
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26111969
133Systemic lupus erythematosus_Homo sapiens_hsa053220.25821389
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25409131
135Sulfur metabolism_Homo sapiens_hsa009200.25292161
136Mismatch repair_Homo sapiens_hsa034300.24791271
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23037085
138Allograft rejection_Homo sapiens_hsa053300.22331347
139Gap junction_Homo sapiens_hsa045400.21998277
140Tuberculosis_Homo sapiens_hsa051520.21961993
141Cell cycle_Homo sapiens_hsa041100.21363918
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20028959
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.19705923
144Estrogen signaling pathway_Homo sapiens_hsa049150.18665274
145Calcium signaling pathway_Homo sapiens_hsa040200.18372325
146Graft-versus-host disease_Homo sapiens_hsa053320.17986686
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.17725302
148Amoebiasis_Homo sapiens_hsa051460.17435828
149Vibrio cholerae infection_Homo sapiens_hsa051100.16905607
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16071643
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.15528317
152Insulin resistance_Homo sapiens_hsa049310.14902762
153Thyroid hormone synthesis_Homo sapiens_hsa049180.14270993
154mTOR signaling pathway_Homo sapiens_hsa041500.14250944
155Proteoglycans in cancer_Homo sapiens_hsa052050.14143103
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13978583
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13952160
158Prolactin signaling pathway_Homo sapiens_hsa049170.13761080
159Notch signaling pathway_Homo sapiens_hsa043300.11919522
160cAMP signaling pathway_Homo sapiens_hsa040240.11820067

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »