CPA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.60933770
2keratinocyte differentiation (GO:0030216)9.12829777
3hemidesmosome assembly (GO:0031581)9.02731886
4intermediate filament organization (GO:0045109)8.05056732
5water homeostasis (GO:0030104)7.99545932
6cell adhesion mediated by integrin (GO:0033627)7.47107403
7skin morphogenesis (GO:0043589)7.19143432
8epidermal cell differentiation (GO:0009913)6.81474125
9epidermis development (GO:0008544)6.66889050
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.15066589
11long-chain fatty acid biosynthetic process (GO:0042759)5.52076044
12glucosamine-containing compound catabolic process (GO:1901072)5.47366174
13endodermal cell differentiation (GO:0035987)5.36543242
14intermediate filament cytoskeleton organization (GO:0045104)5.13211254
15mesodermal cell differentiation (GO:0048333)5.11595753
16dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.08638981
17keratinocyte proliferation (GO:0043616)5.01144429
18intermediate filament-based process (GO:0045103)4.97293863
19ectoderm development (GO:0007398)4.90328978
20regulation of transforming growth factor beta2 production (GO:0032909)4.88676459
21gap junction assembly (GO:0016264)4.84190734
22fatty acid elongation (GO:0030497)4.53586798
23virion attachment to host cell (GO:0019062)4.49150428
24adhesion of symbiont to host cell (GO:0044650)4.49150428
25polarized epithelial cell differentiation (GO:0030859)4.47755015
26keratinocyte development (GO:0003334)4.33241067
27negative regulation of chondrocyte differentiation (GO:0032331)4.23286954
28skin development (GO:0043588)3.80261642
29cell junction assembly (GO:0034329)3.76351104
30cellular response to vitamin D (GO:0071305)3.64936756
31regulation of ruffle assembly (GO:1900027)3.64008579
32adhesion of symbiont to host (GO:0044406)3.63370387
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.60652582
34protein localization to endosome (GO:0036010)3.57704233
35heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.53404297
36cell junction organization (GO:0034330)3.51495664
37hair follicle morphogenesis (GO:0031069)3.51293551
38type B pancreatic cell proliferation (GO:0044342)3.50936217
39negative regulation of keratinocyte proliferation (GO:0010839)3.50771814
40protein retention in ER lumen (GO:0006621)3.50606595
41extracellular matrix disassembly (GO:0022617)3.48795366
42cellular response to vitamin (GO:0071295)3.44179275
43renal filtration (GO:0097205)3.39548009
44neural crest cell development (GO:0014032)3.37840946
45fibrinolysis (GO:0042730)3.37458872
46atrioventricular valve morphogenesis (GO:0003181)3.34958394
47hypotonic response (GO:0006971)3.30684528
48L-serine transport (GO:0015825)3.21797940
49linoleic acid metabolic process (GO:0043651)3.19884886
50epithelium development (GO:0060429)3.16627524
51negative regulation of cell fate specification (GO:0009996)3.15401030
52cell-substrate adherens junction assembly (GO:0007045)3.12082863
53focal adhesion assembly (GO:0048041)3.12082863
54COPI coating of Golgi vesicle (GO:0048205)3.11321961
55Golgi transport vesicle coating (GO:0048200)3.11321961
56negative regulation of epidermis development (GO:0045683)3.10009999
57phosphatidylinositol acyl-chain remodeling (GO:0036149)3.07384136
58mammary gland development (GO:0030879)3.03723453
59keratinization (GO:0031424)23.2676215
60lateral sprouting from an epithelium (GO:0060601)2.96149350
61gland morphogenesis (GO:0022612)2.95762269
62establishment of planar polarity (GO:0001736)2.94052813
63establishment of tissue polarity (GO:0007164)2.94052813
64regulation of apoptotic process involved in morphogenesis (GO:1902337)2.93384645
65planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91345668
66negative regulation of cartilage development (GO:0061037)2.90572634
67facial nerve structural organization (GO:0021612)2.89752395
68long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.89742873
69lipoxygenase pathway (GO:0019372)2.86946696
70cell-substrate junction assembly (GO:0007044)2.86089205
71heparan sulfate proteoglycan metabolic process (GO:0030201)2.85983598
72positive regulation of monocyte chemotaxis (GO:0090026)2.85980179
73molting cycle process (GO:0022404)2.83643610
74hair cycle process (GO:0022405)2.83643610
75wound healing, spreading of cells (GO:0044319)2.83437859
76wound healing, spreading of epidermal cells (GO:0035313)2.83045588
77regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.82994015
78collagen metabolic process (GO:0032963)2.82339980
79regulation of transforming growth factor beta production (GO:0071634)2.82270162
80collagen catabolic process (GO:0030574)2.80358948
81ventricular cardiac muscle cell action potential (GO:0086005)2.78777274
82sphingoid metabolic process (GO:0046519)2.77038780
83cellular copper ion homeostasis (GO:0006878)2.76698915
84regulation of heart rate by cardiac conduction (GO:0086091)2.74314455
85negative regulation of stem cell proliferation (GO:2000647)2.74026446
86regulation of transforming growth factor beta1 production (GO:0032908)2.72099339
87renal system development (GO:0072001)2.71510358
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70484673
89endothelial cell morphogenesis (GO:0001886)2.68824520
90adherens junction assembly (GO:0034333)2.68678382
91phosphatidylserine acyl-chain remodeling (GO:0036150)2.67437402
92regulation of hippo signaling (GO:0035330)2.65748253
93positive regulation of positive chemotaxis (GO:0050927)2.64458692
94serine transport (GO:0032329)2.63008851
95membrane raft organization (GO:0031579)2.62613658
96multicellular organismal macromolecule metabolic process (GO:0044259)2.62158319
97regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.61180081
98mammary gland epithelial cell proliferation (GO:0033598)2.60497196
99multicellular organismal catabolic process (GO:0044243)2.59658557
100peptidyl-proline hydroxylation (GO:0019511)2.58772909
101epithelial cell-cell adhesion (GO:0090136)2.56806735
102regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.56377694
103extracellular matrix organization (GO:0030198)2.55340980
104positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.52489610
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.49975888
106axon extension involved in axon guidance (GO:0048846)2.49975888
107negative regulation of cell fate commitment (GO:0010454)2.47833014
108long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.41413495
109retina homeostasis (GO:0001895)2.40734986
110positive regulation of epidermis development (GO:0045684)2.36871901
111cell wall macromolecule catabolic process (GO:0016998)2.33821068
112cell wall macromolecule metabolic process (GO:0044036)2.33821068
113detection of bacterium (GO:0016045)2.33294407
114regulation of hair follicle development (GO:0051797)2.32906480
115hair follicle development (GO:0001942)2.32681388
116positive regulation of meiotic cell cycle (GO:0051446)2.31830037
117cell communication involved in cardiac conduction (GO:0086065)2.31503560
118sphingosine metabolic process (GO:0006670)2.29704505
119cellular response to calcium ion (GO:0071277)2.28426427
120regulation of cardioblast differentiation (GO:0051890)2.27743815
121cardiac conduction (GO:0061337)2.27495693
122negative regulation of axon extension involved in axon guidance (GO:0048843)2.27221047
123ephrin receptor signaling pathway (GO:0048013)2.26878914
124tooth mineralization (GO:0034505)2.26793070
125phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.26409593
126outer ear morphogenesis (GO:0042473)2.25538334
127fatty-acyl-CoA metabolic process (GO:0035337)2.25408492
128myotube differentiation (GO:0014902)2.25062387
129surfactant homeostasis (GO:0043129)2.24921664
130non-canonical Wnt signaling pathway (GO:0035567)2.23887268
131regulation of keratinocyte differentiation (GO:0045616)2.22617282
132regulation of phospholipase A2 activity (GO:0032429)2.22443308
133regulation of monocyte chemotaxis (GO:0090025)2.20587684
134diol metabolic process (GO:0034311)2.19854060
135regulation of hair cycle (GO:0042634)2.18448009
136regulation of keratinocyte proliferation (GO:0010837)2.17166812
137positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.17153358
138fatty-acyl-CoA biosynthetic process (GO:0046949)2.14954715
139positive regulation of epidermal cell differentiation (GO:0045606)2.14013643
140cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.12381566
141chondrocyte proliferation (GO:0035988)2.11859554
142eyelid development in camera-type eye (GO:0061029)2.10686216
143chemical homeostasis within a tissue (GO:0048875)2.10009356
144positive regulation of hair cycle (GO:0042635)2.08841731
145positive regulation of hair follicle development (GO:0051798)2.08841731
146wound healing (GO:0042060)2.04512249
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.03340200
148regulation of epidermis development (GO:0045682)2.02149993
149muscle filament sliding (GO:0030049)2.01186530
150actin-myosin filament sliding (GO:0033275)2.01186530
151establishment of skin barrier (GO:0061436)17.1835241
152molting cycle (GO:0042303)15.2845931
153hair cycle (GO:0042633)15.2845931
154regulation of water loss via skin (GO:0033561)14.7132383
155desmosome organization (GO:0002934)12.8029863
156peptide cross-linking (GO:0018149)10.0815797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.75855253
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.13179436
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.05813420
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58593789
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.06130871
6TP63_17297297_ChIP-ChIP_HaCaT_Human14.2525305
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.80920995
8PPAR_26484153_Chip-Seq_NCI-H1993_Human1.79714796
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79688916
10EZH2_27304074_Chip-Seq_ESCs_Mouse1.78460739
11SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76736423
12ESR1_21235772_ChIP-Seq_MCF-7_Human1.72304021
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.68493049
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67999873
15JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66207400
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66061718
17* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.63797739
18* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60183641
19* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58719395
20* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58719395
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57965302
22ZNF263_19887448_ChIP-Seq_K562_Human1.56653831
23JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54829637
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51436467
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.48577887
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48301455
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47810020
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47538669
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47538669
30AR_21572438_ChIP-Seq_LNCaP_Human1.47276919
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.45604233
32TP63_23658742_ChIP-Seq_EP156T_Human1.44028122
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42909600
34GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.42592191
35* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42140129
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40520829
37BRD4_25478319_ChIP-Seq_HGPS_Human1.40049851
38RXR_22108803_ChIP-Seq_LS180_Human1.38340824
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35850548
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.34571416
41CTCF_27219007_Chip-Seq_Bcells_Human1.34398325
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.33946886
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33563507
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32521235
45GATA6_21074721_ChIP-Seq_CACO-2_Human1.31991963
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31462908
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29817173
48TP53_18474530_ChIP-ChIP_U2OS_Human1.29434876
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28817449
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28752993
51ERG_20517297_ChIP-Seq_VCAP_Human1.28363706
52* CJUN_26792858_Chip-Seq_BT549_Human1.28185313
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28137698
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27349456
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.23965517
56KLF5_25053715_ChIP-Seq_YYC3_Human1.23481625
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.23191558
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.22721357
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22501747
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22412831
61CTCF_20526341_ChIP-Seq_ESCs_Human1.21048512
62TP53_22127205_ChIP-Seq_IMR90_Human1.19564201
63BCAT_22108803_ChIP-Seq_LS180_Human1.18654278
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17805635
65TP63_22573176_ChIP-Seq_HFKS_Human1.17275872
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.16233498
67CLOCK_20551151_ChIP-Seq_293T_Human1.15789207
68SOX2_20726797_ChIP-Seq_SW620_Human1.13640752
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.12698997
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11925089
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.11673947
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.10367133
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.10221279
74EGR1_19032775_ChIP-ChIP_M12_Human1.09708740
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08998319
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08639729
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07826589
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.05706788
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05212663
80AR_21909140_ChIP-Seq_LNCAP_Human1.04019746
81BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02291195
82AHR_22903824_ChIP-Seq_MCF-7_Human1.02042070
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01609940
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.99730690
85GATA3_24758297_ChIP-Seq_MCF-7_Human0.98503444
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97801849
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96210196
88E2F1_20622854_ChIP-Seq_HELA_Human0.95699809
89TP53_16413492_ChIP-PET_HCT116_Human0.94408205
90RACK7_27058665_Chip-Seq_MCF-7_Human0.93115056
91RUNX1_27514584_Chip-Seq_MCF-7_Human0.92575372
92* RING1B_27294783_Chip-Seq_ESCs_Mouse0.91611535
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90336488
94VDR_22108803_ChIP-Seq_LS180_Human0.89995570
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88780408
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88507284
97* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87578660
98* ATF3_27146783_Chip-Seq_COLON_Human0.87530734
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86552551
100NANOG_20526341_ChIP-Seq_ESCs_Human0.85578068
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83510239
102CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83138946
103TP53_23651856_ChIP-Seq_MEFs_Mouse0.82026952
104BCOR_27268052_Chip-Seq_Bcells_Human0.81871927
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.81863774
106VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81525315
107CEBPB_22108803_ChIP-Seq_LS180_Human0.80804383
108GATA4_25053715_ChIP-Seq_YYC3_Human0.80443893
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80155206
110TAF2_19829295_ChIP-Seq_ESCs_Human0.80074741
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79901056
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79823491
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78577722
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.78329508
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.78222703
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77139450
117TCF4_22108803_ChIP-Seq_LS180_Human0.77018917
118* TBX20_22080862_ChIP-Seq_HEART_Mouse0.75309827
119* TBX20_22328084_ChIP-Seq_HEART_Mouse0.75309827
120BCL6_27268052_Chip-Seq_Bcells_Human0.75235674
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.74910966
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74756924
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74756924
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.74694443
125LXR_22292898_ChIP-Seq_THP-1_Human0.74304763
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.74155146
127GATA6_25053715_ChIP-Seq_YYC3_Human0.73861897
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73498442
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72972972
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.72372373
131MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.72037768
132MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.71653601
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.71415978
134JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71045627
135* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70903964
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70797908
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69416293
138RBPJ_21746931_ChIP-Seq_IB4_Human0.69082490
139ELK4_26923725_Chip-Seq_MESODERM_Mouse0.68557153
140ZFP57_27257070_Chip-Seq_ESCs_Mouse0.68353273
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.65108911
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.62941298
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60613832
144ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.60483216
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.58909206
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.58672540
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.58599756
148* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.57154807
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.56838792
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56507098
151NANOG_18555785_ChIP-Seq_MESCs_Mouse0.56203848
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.55261710
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.54772031
154NANOG_18692474_ChIP-Seq_MEFs_Mouse0.51972463
155* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.50973753
156SMC1_22415368_ChIP-Seq_MEFs_Mouse0.50026727
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.49310945
158EOMES_21245162_ChIP-Seq_HESCs_Human0.48061207
159SALL4_18804426_ChIP-ChIP_XEN_Mouse0.47909483
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.46109030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.40821888
2MP0005275_abnormal_skin_tensile7.41274177
3MP0000579_abnormal_nail_morphology6.03030901
4MP0005501_abnormal_skin_physiology5.15093192
5MP0000647_abnormal_sebaceous_gland3.50968766
6MP0002060_abnormal_skin_morphology3.37012755
7MP0003705_abnormal_hypodermis_morpholog3.35686014
8MP0003941_abnormal_skin_development3.34318869
9MP0010234_abnormal_vibrissa_follicle3.28277486
10MP0001216_abnormal_epidermal_layer3.26458515
11MP0010771_integument_phenotype3.20598963
12MP0004381_abnormal_hair_follicle3.15015728
13MP0000383_abnormal_hair_follicle3.14654178
14MP0001188_hyperpigmentation2.97923642
15MP0002098_abnormal_vibrissa_morphology2.87906859
16MP0004947_skin_inflammation2.86928091
17MP0002254_reproductive_system_inflammat2.65643366
18MP0010678_abnormal_skin_adnexa2.64870161
19MP0000467_abnormal_esophagus_morphology2.63598911
20MP0000377_abnormal_hair_follicle2.50969363
21MP0000427_abnormal_hair_cycle2.36179582
22MP0003453_abnormal_keratinocyte_physiol2.32915771
23MP0005623_abnormal_meninges_morphology2.00874769
24MP0000762_abnormal_tongue_morphology1.97897798
25MP0001243_abnormal_dermal_layer1.86262964
26MP0000566_synostosis1.82906263
27MP0009931_abnormal_skin_appearance1.72018852
28MP0002234_abnormal_pharynx_morphology1.67167905
29MP0005451_abnormal_body_composition1.66655580
30MP0000367_abnormal_coat/_hair1.47869040
31MP0003566_abnormal_cell_adhesion1.41233171
32MP0001191_abnormal_skin_condition1.39020799
33MP0000678_abnormal_parathyroid_gland1.38079225
34MP0008260_abnormal_autophagy1.36008898
35MP0010030_abnormal_orbit_morphology1.35923642
36MP0010352_gastrointestinal_tract_polyps1.26956173
37MP0009053_abnormal_anal_canal1.26575907
38MP0009384_cardiac_valve_regurgitation1.25034242
39MP0005360_urolithiasis1.18499925
40MP0005409_darkened_coat_color1.18489611
41MP0008438_abnormal_cutaneous_collagen1.18132819
42MP0003191_abnormal_cellular_cholesterol1.15758612
43MP0000013_abnormal_adipose_tissue1.09406580
44MP0010368_abnormal_lymphatic_system1.08771279
45MP0004185_abnormal_adipocyte_glucose1.06022909
46MP0002095_abnormal_skin_pigmentation1.05849938
47MP0003091_abnormal_cell_migration1.02920684
48MP0001851_eye_inflammation1.00256275
49MP0001346_abnormal_lacrimal_gland0.99747738
50MP0001661_extended_life_span0.94796448
51MP0005197_abnormal_uvea_morphology0.91273126
52MP0002177_abnormal_outer_ear0.89082903
53MP0001348_abnormal_lacrimal_gland0.84310718
54MP0001340_abnormal_eyelid_morphology0.80954688
55MP0002295_abnormal_pulmonary_circulatio0.80400273
56MP0000858_altered_metastatic_potential0.80265538
57MP0003755_abnormal_palate_morphology0.76015045
58MP0009379_abnormal_foot_pigmentation0.70779591
59MP0005330_cardiomyopathy0.69997443
60MP0006138_congestive_heart_failure0.69127768
61MP0002009_preneoplasia0.68930447
62MP0006054_spinal_hemorrhage0.66784884
63MP0002822_catalepsy0.64562887
64MP0001784_abnormal_fluid_regulation0.64462241
65MP0004233_abnormal_muscle_weight0.62267391
66MP0000003_abnormal_adipose_tissue0.62172820
67MP0002282_abnormal_trachea_morphology0.61653156
68MP0000733_abnormal_muscle_development0.59919672
69MP0003315_abnormal_perineum_morphology0.58404543
70MP0008932_abnormal_embryonic_tissue0.58293785
71MP0000538_abnormal_urinary_bladder0.57002519
72MP0003786_premature_aging0.55983519
73MP0005023_abnormal_wound_healing0.55646548
74MP0004019_abnormal_vitamin_homeostasis0.54834161
75MP0003385_abnormal_body_wall0.54514182
76MP0005621_abnormal_cell_physiology0.54306713
77MP0000537_abnormal_urethra_morphology0.54024558
78MP0003279_aneurysm0.53599005
79MP0000751_myopathy0.53346434
80MP0000534_abnormal_ureter_morphology0.53216222
81MP0004134_abnormal_chest_morphology0.52755006
82MP0001849_ear_inflammation0.48588160
83MP0000627_abnormal_mammary_gland0.48325534
84MP0010386_abnormal_urinary_bladder0.47812188
85MP0000428_abnormal_craniofacial_morphol0.46573054
86MP0000767_abnormal_smooth_muscle0.45937396
87MP0000465_gastrointestinal_hemorrhage0.45257834
88MP0003122_maternal_imprinting0.44714445
89MP0003045_fibrosis0.44622103
90MP0002111_abnormal_tail_morphology0.44366651
91MP0009780_abnormal_chondrocyte_physiolo0.44343562
92MP0003935_abnormal_craniofacial_develop0.44173074
93MP0001881_abnormal_mammary_gland0.43191090
94MP0003011_delayed_dark_adaptation0.43044279
95MP0004272_abnormal_basement_membrane0.41890969
96MP0005257_abnormal_intraocular_pressure0.41098771
97MP0004782_abnormal_surfactant_physiolog0.39676434
98MP0004858_abnormal_nervous_system0.38708404
99MP0002233_abnormal_nose_morphology0.37660681
100MP0002249_abnormal_larynx_morphology0.35409492
101MP0001299_abnormal_eye_distance/0.34089087
102MP0002877_abnormal_melanocyte_morpholog0.33297674
103MP0000750_abnormal_muscle_regeneration0.33145666
104MP0005503_abnormal_tendon_morphology0.32959951
105MP0008789_abnormal_olfactory_epithelium0.28361399
106MP0001958_emphysema0.27478525
107MP0009250_abnormal_appendicular_skeleto0.26304935
108MP0000462_abnormal_digestive_system0.25933910
109MP0003950_abnormal_plasma_membrane0.24877977
110MP0005508_abnormal_skeleton_morphology0.24034505
111MP0003880_abnormal_central_pattern0.23771931
112MP0000749_muscle_degeneration0.22775030
113MP0000432_abnormal_head_morphology0.22597219
114MP0008569_lethality_at_weaning0.22127049
115MP0006276_abnormal_autonomic_nervous0.20869969
116MP0002089_abnormal_postnatal_growth/wei0.19346948
117MP0002006_tumorigenesis0.18882799
118MP0002896_abnormal_bone_mineralization0.18564249
119MP0004742_abnormal_vestibular_system0.18400908
120MP0002109_abnormal_limb_morphology0.18171610
121MP0001186_pigmentation_phenotype0.17966884
122MP0003448_altered_tumor_morphology0.17955981
123MP0005394_taste/olfaction_phenotype0.17872879
124MP0005499_abnormal_olfactory_system0.17872879
125MP0002697_abnormal_eye_size0.17722718
126MP0000759_abnormal_skeletal_muscle0.17402934
127MP0004270_analgesia0.16745802
128MP0000049_abnormal_middle_ear0.16655955
129MP0005248_abnormal_Harderian_gland0.16441418
130MP0004264_abnormal_extraembryonic_tissu0.16088757
131MP0005193_abnormal_anterior_eye0.15956321
132MP0001177_atelectasis0.15608209
133MP0001542_abnormal_bone_strength0.15528460

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.56509681
2Abnormality of nail color (HP:0100643)8.74695408
3Hypotrichosis (HP:0001006)8.46218609
4Conjunctival hamartoma (HP:0100780)7.85133232
5Palmoplantar hyperkeratosis (HP:0000972)7.84888842
6Palmar hyperkeratosis (HP:0010765)7.45968002
7Plantar hyperkeratosis (HP:0007556)7.42134366
8Woolly hair (HP:0002224)6.64265302
9Onycholysis (HP:0001806)6.45464298
10Thick nail (HP:0001805)6.44268872
11Pili torti (HP:0003777)6.16464981
12Erythroderma (HP:0001019)6.14706210
13Erythema (HP:0010783)6.08784293
14Fragile nails (HP:0001808)5.23221418
15Right ventricular cardiomyopathy (HP:0011663)4.92050195
16Hamartoma of the eye (HP:0010568)4.91216484
17Congenital ichthyosiform erythroderma (HP:0007431)4.90306359
18Milia (HP:0001056)4.65044284
19Alopecia of scalp (HP:0002293)4.59146999
20Abnormal blistering of the skin (HP:0008066)4.41658764
21Follicular hyperkeratosis (HP:0007502)4.34057128
22Nail dystrophy (HP:0008404)4.33396581
23Selective tooth agenesis (HP:0001592)4.11691363
24Gangrene (HP:0100758)4.09620816
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.93410418
26Oral leukoplakia (HP:0002745)3.86881280
27Hypoplasia of dental enamel (HP:0006297)3.81237964
28Pterygium (HP:0001059)3.74538621
29Abnormal hair laboratory examination (HP:0003328)3.63275725
30Palmoplantar keratoderma (HP:0000982)3.45416980
31Corneal erosion (HP:0200020)3.36326629
32Ridged nail (HP:0001807)3.20729966
33Dry hair (HP:0011359)3.14064557
34Atrophic scars (HP:0001075)3.02851745
35Hypohidrosis (HP:0000966)2.96721202
36Natal tooth (HP:0000695)2.94464370
37Parakeratosis (HP:0001036)2.93163922
38Sparse eyelashes (HP:0000653)2.92731809
39Advanced eruption of teeth (HP:0006288)2.89259375
40Eczematoid dermatitis (HP:0000976)2.88933119
41Ectropion (HP:0000656)2.88321333
42Hypergammaglobulinemia (HP:0010702)2.79924054
43Arterial tortuosity (HP:0005116)2.66616051
44Brittle hair (HP:0002299)2.63756381
45Curly hair (HP:0002212)2.62833296
46Type 1 muscle fiber predominance (HP:0003803)2.59470786
47Pruritus (HP:0000989)2.56747269
48Short nail (HP:0001799)2.52515190
49Ventricular tachycardia (HP:0004756)2.50668089
50Abnormality of hair growth rate (HP:0011363)2.46047823
51Slow-growing hair (HP:0002217)2.46047823
52Lip pit (HP:0100267)2.42562115
53Fatigable weakness (HP:0003473)2.40428591
54Abnormality of the neuromuscular junction (HP:0003398)2.40428591
55Vascular tortuosity (HP:0004948)2.35640150
56Melanocytic nevus (HP:0000995)2.34007717
57Hamartoma (HP:0010566)2.33052617
58Ankyloglossia (HP:0010296)2.30618158
59Popliteal pterygium (HP:0009756)2.27308455
60Hyporeflexia of lower limbs (HP:0002600)2.25170258
61Hypodontia (HP:0000668)2.23457083
62Increased connective tissue (HP:0009025)2.22664329
63Oligodontia (HP:0000677)2.21362835
64Hyperhidrosis (HP:0000975)2.19808100
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.19528331
66Abnormality of oral frenula (HP:0000190)2.17652603
67Round ear (HP:0100830)2.16872632
68Verrucae (HP:0200043)2.14786423
69Papilloma (HP:0012740)2.14786423
70Muscle fiber inclusion bodies (HP:0100299)2.14709694
71Cervical subluxation (HP:0003308)2.14268880
72Abnormality of placental membranes (HP:0011409)2.13507609
73Amniotic constriction ring (HP:0009775)2.13507609
74Nemaline bodies (HP:0003798)2.12984503
75Laryngomalacia (HP:0001601)2.12197828
76Protrusio acetabuli (HP:0003179)2.10762150
77Hypoplastic labia majora (HP:0000059)2.10077985
78Cardiovascular calcification (HP:0011915)2.09210231
79Lack of skin elasticity (HP:0100679)2.07651226
80Corneal dystrophy (HP:0001131)2.07140071
81Aplasia cutis congenita (HP:0001057)2.06721050
82Vertebral compression fractures (HP:0002953)2.05740001
83Distal arthrogryposis (HP:0005684)2.05062697
84Myopathic facies (HP:0002058)2.03958269
85Vascular calcification (HP:0004934)2.00615020
86Autoamputation (HP:0001218)1.98537597
87Anonychia (HP:0001798)1.98125911
88Mitral stenosis (HP:0001718)1.97175514
89Acanthosis nigricans (HP:0000956)1.91781911
90Abnormality of the distal phalanges of the toes (HP:0010182)1.91756854
91Broad face (HP:0000283)1.90494266
92Fragile skin (HP:0001030)1.87748226
93Abnormality of the labia majora (HP:0012881)1.86832747
94Distal lower limb muscle weakness (HP:0009053)1.86655266
95Aortic dissection (HP:0002647)1.85377698
96Esophageal atresia (HP:0002032)1.84398942
97Ureteral stenosis (HP:0000071)1.78598491
98Calcaneovalgus deformity (HP:0001848)1.77621662
99Trismus (HP:0000211)1.76617188
100Neck muscle weakness (HP:0000467)1.74943153
101Congenital, generalized hypertrichosis (HP:0004540)1.73673725
102Death in infancy (HP:0001522)1.72400437
103Squamous cell carcinoma (HP:0002860)1.71975761
104Hoarse voice (HP:0001609)1.71814630
105Sudden death (HP:0001699)1.71257337
106Ureteral obstruction (HP:0006000)1.68923325
107Tibial bowing (HP:0002982)1.67714455
108Wormian bones (HP:0002645)1.66617332
109Carious teeth (HP:0000670)1.65626717
110Abnormality of the fingernails (HP:0001231)1.64320278
111Ventricular fibrillation (HP:0001663)1.63442289
112Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.63270070
113Exercise-induced myalgia (HP:0003738)1.63156483
114Sparse scalp hair (HP:0002209)1.62659725
115Osteolytic defects of the hand bones (HP:0009699)1.61998195
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.61998195
117Premature rupture of membranes (HP:0001788)1.61722615
118Blepharitis (HP:0000498)1.61705307
119Absent eyelashes (HP:0000561)1.61591900
120Back pain (HP:0003418)1.60457480
121Elbow flexion contracture (HP:0002987)1.60401348
122Skin ulcer (HP:0200042)1.59906995
123Poikiloderma (HP:0001029)1.59673136
124Deformed tarsal bones (HP:0008119)1.57259059
125Entropion (HP:0000621)1.56788098
126Bladder diverticulum (HP:0000015)1.56698181
127Concave nail (HP:0001598)1.56578477
128Breast hypoplasia (HP:0003187)1.56054433
129Distal lower limb amyotrophy (HP:0008944)1.55472066
130Recurrent corneal erosions (HP:0000495)1.55452277
131Ulnar deviation of the wrist (HP:0003049)1.53485817
132Cheilitis (HP:0100825)1.53361931
133Absent phalangeal crease (HP:0006109)1.53022127
134Vertebral arch anomaly (HP:0008438)1.52388666
135Knee flexion contracture (HP:0006380)1.52320650
136Ulnar bowing (HP:0003031)1.51014643
137Muscle fiber splitting (HP:0003555)1.49599170
138Abnormality of the axillary hair (HP:0100134)1.46076056
139Abnormality of secondary sexual hair (HP:0009888)1.46076056
140Amelogenesis imperfecta (HP:0000705)1.45826879
141Achilles tendon contracture (HP:0001771)1.45336412
142Mildly elevated creatine phosphokinase (HP:0008180)1.40328904
143Lower limb amyotrophy (HP:0007210)1.39497992
144Increased variability in muscle fiber diameter (HP:0003557)1.38024930
145Neonatal onset (HP:0003623)1.36201138
146Abnormality of skeletal muscle fiber size (HP:0012084)1.36155809
147Aplasia involving bones of the extremities (HP:0009825)1.35313108
148Aplasia of the phalanges of the hand (HP:0009802)1.35313108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.98051619
2ARAF4.13844018
3NTRK13.87225874
4MAPKAPK33.60528610
5MST1R3.32852304
6FGFR13.24371047
7CASK3.22550732
8EPHB22.88850352
9BCR2.87667803
10MAP3K32.84583025
11SIK12.75552673
12MAP3K122.66258103
13PIK3CG2.58486530
14MYLK2.49864523
15ERN12.46013631
16TTN2.40386419
17FLT32.34828095
18PAK42.23933724
19NME12.23702737
20MAP3K111.89903405
21MAP2K41.85786189
22LATS11.78053722
23EPHA21.75515588
24MAP2K61.70455588
25TAOK11.68382243
26MAP3K21.61365293
27MAP3K61.59171682
28NTRK21.56051510
29KSR21.53489696
30OBSCN1.49924844
31ERBB31.44625622
32CDK191.44578426
33RPS6KB21.39957067
34TIE11.37439182
35LATS21.23643481
36PBK1.22842741
37DDR21.21609650
38RIPK11.20181766
39DYRK1B1.16849501
40BRAF1.15502795
41PAK21.15449331
42EIF2AK11.14942814
43FGFR31.14680237
44RAF11.13594462
45EPHA31.10292281
46LIMK11.09751016
47TGFBR21.05576110
48STK381.04439413
49RPS6KA21.03980224
50MAP3K91.03674455
51TGFBR11.02836476
52PIM21.01272819
53PHKG10.99147550
54PHKG20.99147550
55DYRK20.94839233
56TESK10.94464951
57IRAK30.93274212
58MAPKAPK20.91041103
59MET0.90843175
60NTRK30.86278291
61TRPM70.85523643
62NEK60.82100550
63ERBB40.78442929
64MAP3K10.78354391
65PDGFRA0.76967279
66ADRBK10.75063101
67PAK30.74849686
68MST40.74770335
69ILK0.73883527
70NEK10.72758569
71ABL20.72567694
72NME20.71655827
73CAMK2G0.71623874
74BUB10.69931454
75MAPK130.69265733
76SCYL20.69186712
77FGR0.68339797
78MAP2K10.65157049
79ICK0.63093818
80PDGFRB0.62969143
81WNK10.62232232
82MAP3K50.59599283
83FGFR20.58967173
84MAP3K80.58952439
85UHMK10.56443326
86PRKD20.53330462
87SMG10.52519625
88MINK10.52496990
89BMX0.51893465
90PTK20.51794324
91TSSK60.51790264
92STK38L0.50818207
93ROCK20.50788479
94CDK60.50447624
95PTK60.50283823
96PDK40.50245773
97PDK30.50245773
98FGFR40.49462514
99MTOR0.49432342
100ROCK10.49260445
101TRIB30.48505369
102LMTK20.48486158
103RPS6KA40.47717236
104MARK10.47305404
105PRKCE0.47089582
106CSF1R0.46988224
107STK240.46319471
108STK100.46153797
109GSK3A0.46027765
110PRKCI0.45797880
111PKN10.45436167
112NEK90.45028638
113EIF2AK30.44699302
114TNK20.44684218
115CDK120.44172565
116MOS0.44160758
117LRRK20.43547195
118DAPK20.43100615
119YES10.42047307
120PDK20.41936856
121MAP3K40.40675120
122FYN0.40467224
123PLK20.39986898
124BLK0.39647848
125PAK60.37178999
126CDK50.37058698
127CLK10.36032669
128MAP3K70.35803447
129EPHB10.35379011
130PRKACA0.35321326
131RET0.34800590
132MAPKAPK50.34596843
133CDK140.34507431
134MAPK120.33951283
135CDK180.33839094
136KSR10.33069260
137SRC0.32676415
138CAMK2A0.32227573
139TYK20.29806819
140INSR0.29662057
141PTK2B0.29643120
142CDK11A0.29057872
143STK30.28921842
144DAPK30.28608393
145CDK150.28557496
146CSNK1A10.28468404
147PAK10.28312620
148CDK80.26914666
149CDK90.25059949
150CAMK2B0.24612451
151RPS6KA10.22971647
152AURKB0.22748287
153PRKG20.22264467
154ERBB20.21677965
155CAMK2D0.20895303
156MAPK70.20394406

Predicted pathways (KEGG)

RankGene SetZ-score
1Small cell lung cancer_Homo sapiens_hsa052223.47515692
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.04228734
3Linoleic acid metabolism_Homo sapiens_hsa005912.71956306
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68972621
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.32203499
6Fatty acid elongation_Homo sapiens_hsa000622.31395214
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01372238
8Axon guidance_Homo sapiens_hsa043601.94870606
9Arachidonic acid metabolism_Homo sapiens_hsa005901.89257409
10Phenylalanine metabolism_Homo sapiens_hsa003601.88018017
11N-Glycan biosynthesis_Homo sapiens_hsa005101.85683006
12GnRH signaling pathway_Homo sapiens_hsa049121.84087147
13Collecting duct acid secretion_Homo sapiens_hsa049661.82463511
14Ether lipid metabolism_Homo sapiens_hsa005651.68276949
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.67458275
16Sphingolipid metabolism_Homo sapiens_hsa006001.66612871
17Renin secretion_Homo sapiens_hsa049241.65048803
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60419421
19Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.51398701
20Proteasome_Homo sapiens_hsa030501.49362076
21Long-term depression_Homo sapiens_hsa047301.48533156
22ECM-receptor interaction_Homo sapiens_hsa045121.48178526
23Basal cell carcinoma_Homo sapiens_hsa052171.42540449
24Olfactory transduction_Homo sapiens_hsa047401.42043640
25Phototransduction_Homo sapiens_hsa047441.38724326
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.38326210
27Bladder cancer_Homo sapiens_hsa052191.36929723
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36841612
29VEGF signaling pathway_Homo sapiens_hsa043701.33973838
30Vibrio cholerae infection_Homo sapiens_hsa051101.33155814
31Serotonergic synapse_Homo sapiens_hsa047261.33015792
32Melanogenesis_Homo sapiens_hsa049161.32961096
33Other glycan degradation_Homo sapiens_hsa005111.32820064
34Staphylococcus aureus infection_Homo sapiens_hsa051501.31391331
35Synaptic vesicle cycle_Homo sapiens_hsa047211.25634044
36Gastric acid secretion_Homo sapiens_hsa049711.25343743
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.21600562
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19571191
39Adherens junction_Homo sapiens_hsa045201.17427800
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.15037864
41Fat digestion and absorption_Homo sapiens_hsa049751.14766254
42Glycerolipid metabolism_Homo sapiens_hsa005611.13895401
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12865887
44Proteoglycans in cancer_Homo sapiens_hsa052051.12450152
45Long-term potentiation_Homo sapiens_hsa047201.12217664
46Pathways in cancer_Homo sapiens_hsa052001.12098520
47Salivary secretion_Homo sapiens_hsa049701.10680058
48Oxytocin signaling pathway_Homo sapiens_hsa049211.10399384
49Hedgehog signaling pathway_Homo sapiens_hsa043401.09969462
50Tight junction_Homo sapiens_hsa045301.09952178
51Glioma_Homo sapiens_hsa052141.07063481
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04958596
53Gap junction_Homo sapiens_hsa045401.04389915
54Pertussis_Homo sapiens_hsa051331.03720739
55Circadian entrainment_Homo sapiens_hsa047131.03124682
56Phagosome_Homo sapiens_hsa041451.02424040
57Steroid biosynthesis_Homo sapiens_hsa001001.01945414
58Ras signaling pathway_Homo sapiens_hsa040141.01518068
59Galactose metabolism_Homo sapiens_hsa000521.00988757
60Tyrosine metabolism_Homo sapiens_hsa003501.00637124
61Hippo signaling pathway_Homo sapiens_hsa043901.00433252
62Chronic myeloid leukemia_Homo sapiens_hsa052201.00124461
63Histidine metabolism_Homo sapiens_hsa003400.99479694
64Dilated cardiomyopathy_Homo sapiens_hsa054140.98262478
65Pancreatic cancer_Homo sapiens_hsa052120.97409728
66Shigellosis_Homo sapiens_hsa051310.95532343
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95123634
68Dopaminergic synapse_Homo sapiens_hsa047280.94886123
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94508604
70Amoebiasis_Homo sapiens_hsa051460.93607089
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89584705
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88276405
73Sulfur metabolism_Homo sapiens_hsa009200.87594316
74Estrogen signaling pathway_Homo sapiens_hsa049150.87322471
75Calcium signaling pathway_Homo sapiens_hsa040200.86745733
76Lysosome_Homo sapiens_hsa041420.86190086
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85526849
78Amphetamine addiction_Homo sapiens_hsa050310.83803769
79ErbB signaling pathway_Homo sapiens_hsa040120.83270005
80Focal adhesion_Homo sapiens_hsa045100.83193610
81TGF-beta signaling pathway_Homo sapiens_hsa043500.83058630
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82750365
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.81273515
84Rap1 signaling pathway_Homo sapiens_hsa040150.80714933
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78303691
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76023826
87Pancreatic secretion_Homo sapiens_hsa049720.74794842
88Thyroid cancer_Homo sapiens_hsa052160.73112241
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71237847
90Salmonella infection_Homo sapiens_hsa051320.70758695
91Wnt signaling pathway_Homo sapiens_hsa043100.69702379
92Glutamatergic synapse_Homo sapiens_hsa047240.68054761
93MicroRNAs in cancer_Homo sapiens_hsa052060.67756166
94Alzheimers disease_Homo sapiens_hsa050100.67598069
95Dorso-ventral axis formation_Homo sapiens_hsa043200.67552766
96Renal cell carcinoma_Homo sapiens_hsa052110.66483777
97Nicotine addiction_Homo sapiens_hsa050330.66426188
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63481074
99Rheumatoid arthritis_Homo sapiens_hsa053230.62884141
100Platelet activation_Homo sapiens_hsa046110.62508691
101MAPK signaling pathway_Homo sapiens_hsa040100.60252395
102Ovarian steroidogenesis_Homo sapiens_hsa049130.59713826
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58842001
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57985405
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57860479
106Non-small cell lung cancer_Homo sapiens_hsa052230.55575128
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.55368219
108Toxoplasmosis_Homo sapiens_hsa051450.54783089
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54334124
110Protein digestion and absorption_Homo sapiens_hsa049740.53413151
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53076561
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52709253
113Endometrial cancer_Homo sapiens_hsa052130.52276276
114Taste transduction_Homo sapiens_hsa047420.51818607
115Notch signaling pathway_Homo sapiens_hsa043300.51495749
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.51164419
117Vitamin digestion and absorption_Homo sapiens_hsa049770.49846203
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49829066
119Apoptosis_Homo sapiens_hsa042100.48501697
120Melanoma_Homo sapiens_hsa052180.48017361
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47142552
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47040071
123Endocytosis_Homo sapiens_hsa041440.46816835
124Acute myeloid leukemia_Homo sapiens_hsa052210.45696234
125Prion diseases_Homo sapiens_hsa050200.44989451
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44962938
127cAMP signaling pathway_Homo sapiens_hsa040240.44682536
128p53 signaling pathway_Homo sapiens_hsa041150.43771318
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43617826
130Tuberculosis_Homo sapiens_hsa051520.43507873
131Hepatitis C_Homo sapiens_hsa051600.42462014
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.42393270
133Fructose and mannose metabolism_Homo sapiens_hsa000510.41978003
134Prostate cancer_Homo sapiens_hsa052150.41733453
135Protein export_Homo sapiens_hsa030600.40866917
136Insulin signaling pathway_Homo sapiens_hsa049100.38582942
137Inositol phosphate metabolism_Homo sapiens_hsa005620.38385381
138Starch and sucrose metabolism_Homo sapiens_hsa005000.35771297
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34374298
140Malaria_Homo sapiens_hsa051440.26820407
141Glutathione metabolism_Homo sapiens_hsa004800.26546116
142Selenocompound metabolism_Homo sapiens_hsa004500.26031936
143Mineral absorption_Homo sapiens_hsa049780.23805078
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17749562
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17500250
146Sulfur relay system_Homo sapiens_hsa041220.16614381

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