CPA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a member of the peptidase M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)7.26156420
2regulation of transmission of nerve impulse (GO:0051969)6.16188309
3L-phenylalanine metabolic process (GO:0006558)5.56860224
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56860224
5response to redox state (GO:0051775)4.93328585
6superoxide anion generation (GO:0042554)4.54151459
7response to peptidoglycan (GO:0032494)4.44794360
8G-protein coupled receptor internalization (GO:0002031)4.39132944
9mammary gland epithelial cell proliferation (GO:0033598)4.38025975
10anterior/posterior axis specification, embryo (GO:0008595)4.37272537
11terpenoid biosynthetic process (GO:0016114)4.33254236
12ear development (GO:0043583)4.11293082
13interleukin-6-mediated signaling pathway (GO:0070102)4.04561275
14cellular response to arsenic-containing substance (GO:0071243)3.99053701
15acrosome assembly (GO:0001675)3.96364777
16ER overload response (GO:0006983)3.88415561
17cell wall macromolecule metabolic process (GO:0044036)3.87829297
18regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.87223304
19positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.87223304
20polyamine biosynthetic process (GO:0006596)3.83202894
21response to hydroperoxide (GO:0033194)3.82406697
22prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.70792272
23cell wall macromolecule catabolic process (GO:0016998)3.66625742
24regulation of vacuole organization (GO:0044088)3.64658091
25regulation of T-helper 2 cell differentiation (GO:0045628)3.60444547
26autophagic vacuole fusion (GO:0000046)3.59429509
27cellular response to zinc ion (GO:0071294)3.58989906
28daunorubicin metabolic process (GO:0044597)3.57992154
29polyketide metabolic process (GO:0030638)3.57992154
30doxorubicin metabolic process (GO:0044598)3.57992154
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.53217605
32L-phenylalanine catabolic process (GO:0006559)3.53217605
33ribonucleoprotein complex disassembly (GO:0032988)3.52173731
34intermediate filament organization (GO:0045109)3.51009123
35negative regulation of granulocyte differentiation (GO:0030853)3.46561289
36membrane raft organization (GO:0031579)3.45578424
37endosome to lysosome transport (GO:0008333)3.44707353
38embryonic viscerocranium morphogenesis (GO:0048703)3.44667894
39organelle disassembly (GO:1903008)3.44647938
40DNA strand renaturation (GO:0000733)3.41863358
41pyrimidine-containing compound transmembrane transport (GO:0072531)3.40594964
42organ formation (GO:0048645)3.38389370
43pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.37259328
44positive regulation of cellular amide metabolic process (GO:0034250)3.34923151
45positive regulation of neurological system process (GO:0031646)3.34900467
46peptide catabolic process (GO:0043171)3.32258521
47positive regulation of type 2 immune response (GO:0002830)3.30721968
48dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.29306177
49amine catabolic process (GO:0009310)3.27130618
50cellular biogenic amine catabolic process (GO:0042402)3.27130618
51female gonad development (GO:0008585)3.25592720
52neutrophil activation involved in immune response (GO:0002283)3.22957418
53positive regulation of protein import into nucleus, translocation (GO:0033160)3.20724778
54regulation of immunoglobulin secretion (GO:0051023)3.18630846
55regulation of non-canonical Wnt signaling pathway (GO:2000050)3.16031927
56phosphatidylinositol dephosphorylation (GO:0046856)3.13628742
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.10452207
58negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.09666910
59mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09386966
60mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09386966
61righting reflex (GO:0060013)3.06302089
62positive regulation of cellular amine metabolic process (GO:0033240)3.06037900
63deoxyribose phosphate biosynthetic process (GO:0046385)3.05897981
642-deoxyribonucleotide biosynthetic process (GO:0009265)3.05897981
65cilium or flagellum-dependent cell motility (GO:0001539)3.05414118
66positive regulation of T-helper cell differentiation (GO:0045624)3.04939035
67protein neddylation (GO:0045116)3.02728147
68negative regulation of lipid storage (GO:0010888)3.00355678
69organelle membrane fusion (GO:0090174)2.99062153
70negative regulation of keratinocyte proliferation (GO:0010839)2.98771200
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.98624744
72startle response (GO:0001964)2.98228500
73energy homeostasis (GO:0097009)2.93903706
74DNA integration (GO:0015074)2.91721749
75regulation of acrosome reaction (GO:0060046)2.91192344
76positive regulation of focal adhesion assembly (GO:0051894)2.90230664
77positive regulation of cell junction assembly (GO:1901890)2.90230664
78branch elongation of an epithelium (GO:0060602)2.88825367
79detection of other organism (GO:0098543)2.88799609
80positive regulation of interleukin-1 beta secretion (GO:0050718)2.87963969
81retinal metabolic process (GO:0042574)2.86299287
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83509796
83response to host immune response (GO:0052572)2.83509796
84histone H3-K36 demethylation (GO:0070544)2.83415165
85limb bud formation (GO:0060174)2.82837577
86chemical homeostasis within a tissue (GO:0048875)2.82461282
87peptidyl-proline hydroxylation (GO:0019511)2.82377690
88superoxide metabolic process (GO:0006801)2.81667803
89C-terminal protein lipidation (GO:0006501)2.81101180
90androgen biosynthetic process (GO:0006702)2.80128482
91centriole assembly (GO:0098534)2.78574207
92histone H3-K4 trimethylation (GO:0080182)2.78410851
93phospholipid dephosphorylation (GO:0046839)2.78251237
94regulation of germinal center formation (GO:0002634)2.77956312
95inner ear receptor stereocilium organization (GO:0060122)2.77580933
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.77280557
97polyamine metabolic process (GO:0006595)2.76879345
98cellular biogenic amine biosynthetic process (GO:0042401)2.76725816
99regulation of DNA endoreduplication (GO:0032875)2.72993410
100cellular response to gamma radiation (GO:0071480)2.72989003
101extracellular negative regulation of signal transduction (GO:1900116)2.72077819
102extracellular regulation of signal transduction (GO:1900115)2.72077819
103platelet dense granule organization (GO:0060155)2.71813146
104auditory receptor cell stereocilium organization (GO:0060088)2.71037573
105mesenchymal cell differentiation (GO:0048762)2.70438779
106regulation of transforming growth factor beta1 production (GO:0032908)2.69635574
107detection of bacterium (GO:0016045)2.69595180
108negative regulation of gluconeogenesis (GO:0045721)2.69465810
109spermatid nucleus differentiation (GO:0007289)2.68619644
110negative regulation of chemokine production (GO:0032682)2.67064566
111regulation of receptor recycling (GO:0001919)2.66510021
112left/right axis specification (GO:0070986)2.66115854
113protein localization to cilium (GO:0061512)2.65500945
114reflex (GO:0060004)2.65103859
115regulation of T-helper cell differentiation (GO:0045622)2.64011833
116regulation of activation of Janus kinase activity (GO:0010533)2.63678018
117positive regulation of p38MAPK cascade (GO:1900745)2.63589591
118positive regulation of interleukin-1 secretion (GO:0050716)2.63262127
119xenobiotic catabolic process (GO:0042178)2.63128448
120nucleotide-sugar biosynthetic process (GO:0009226)2.62371945
121replicative senescence (GO:0090399)2.61047982
122cysteine metabolic process (GO:0006534)2.59811930
123negative regulation of osteoblast proliferation (GO:0033689)2.59629033
124positive regulation of adherens junction organization (GO:1903393)2.59036593
125germinal center formation (GO:0002467)2.57034528
126norepinephrine metabolic process (GO:0042415)2.56938642
127regulation of platelet aggregation (GO:0090330)2.54615299
128detection of molecule of bacterial origin (GO:0032490)2.54241202
129aromatic amino acid family catabolic process (GO:0009074)2.53701843
130embryonic camera-type eye development (GO:0031076)2.53684269
131C-terminal protein amino acid modification (GO:0018410)2.52948309
132dendritic cell chemotaxis (GO:0002407)2.52897634
133granulocyte activation (GO:0036230)2.52887116
134adenosine metabolic process (GO:0046085)2.50858761
135amine biosynthetic process (GO:0009309)2.50598075
136modulation by virus of host process (GO:0019054)2.50005025
137positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.49953653
138phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.49642531
139facial nerve structural organization (GO:0021612)2.49590061
140aromatic amino acid family metabolic process (GO:0009072)2.48356086
141cranial nerve structural organization (GO:0021604)2.47546107
142modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47423929
143positive regulation by organism of defense response of other organism involved in symbiotic interact2.47423929
144modulation by symbiont of host immune response (GO:0052553)2.47423929
145positive regulation by symbiont of host defense response (GO:0052509)2.47423929
146modulation by symbiont of host defense response (GO:0052031)2.47423929
147modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47423929
148sulfate transport (GO:0008272)2.46954486
149regulation of interleukin-1 beta secretion (GO:0050706)2.46560330
150regulation of NIK/NF-kappaB signaling (GO:1901222)2.46456537
151negative regulation of mast cell activation (GO:0033004)2.46264864
152I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.46250925
153mesenchymal-epithelial cell signaling (GO:0060638)2.45120710
154presynaptic membrane assembly (GO:0097105)2.44516808
155regulation of pigment cell differentiation (GO:0050932)2.42872179
156ganglion development (GO:0061548)2.41855506
157negative regulation of homotypic cell-cell adhesion (GO:0034111)2.41544500
158regulation of timing of cell differentiation (GO:0048505)2.40728822
159cell morphogenesis involved in neuron differentiation (GO:0048667)2.39959090
160positive regulation of heat generation (GO:0031652)2.39514613
161membrane budding (GO:0006900)2.39202995
162dendritic cell migration (GO:0036336)2.39049200
163pyrimidine-containing compound salvage (GO:0008655)2.38527559
164pyrimidine nucleoside salvage (GO:0043097)2.38527559
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.37610906
166response to host (GO:0075136)2.37610906
167response to host defenses (GO:0052200)2.37610906
168preassembly of GPI anchor in ER membrane (GO:0016254)2.37604267
169microtubule depolymerization (GO:0007019)2.37506948
170positive regulation of uterine smooth muscle contraction (GO:0070474)2.37149451
171regulation of T-helper 1 cell differentiation (GO:0045625)2.37064931
172sulfate transmembrane transport (GO:1902358)2.37024740
173positive regulation of CREB transcription factor activity (GO:0032793)2.36982200
174response to X-ray (GO:0010165)2.35710724
175negative regulation of protein secretion (GO:0050709)2.34649165
176negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.33236164
177negative regulation of translation, ncRNA-mediated (GO:0040033)2.33236164
178regulation of translation, ncRNA-mediated (GO:0045974)2.33236164
179negative regulation of cytokine secretion (GO:0050710)2.33115134
180interferon-gamma production (GO:0032609)2.32591374
181negative regulation of myoblast differentiation (GO:0045662)2.32279281
182negative regulation of synaptic transmission, GABAergic (GO:0032229)2.32011327
183keratinocyte development (GO:0003334)2.31557519
184opioid receptor signaling pathway (GO:0038003)2.30382374
185regulation of male gonad development (GO:2000018)2.28081705
186mitochondrion distribution (GO:0048311)2.27082230
187glucocorticoid biosynthetic process (GO:0006704)2.26913758
188polyol transport (GO:0015791)2.26871647
189cell proliferation in forebrain (GO:0021846)2.26609238
190developmental pigmentation (GO:0048066)2.25941325
191dentate gyrus development (GO:0021542)2.25399736
192lymphoid progenitor cell differentiation (GO:0002320)2.25381641
193androgen metabolic process (GO:0008209)2.24995424
194photoreceptor cell maintenance (GO:0045494)2.23702349
195cell differentiation involved in metanephros development (GO:0072202)2.23662308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.90827439
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.21416292
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.20642230
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.07356420
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83492227
6* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.78980768
7CJUN_26792858_Chip-Seq_BT549_Human2.75351283
8PCGF2_27294783_Chip-Seq_NPCs_Mouse2.61547487
9* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.50428062
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.49939786
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47665334
12* FLI1_27457419_Chip-Seq_LIVER_Mouse2.45239584
13EZH2_22144423_ChIP-Seq_EOC_Human2.41982246
14* NFE2_27457419_Chip-Seq_LIVER_Mouse2.38555502
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38273690
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.25282982
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22213521
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21931949
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.21169021
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21071609
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.16503296
22* EZH2_27294783_Chip-Seq_NPCs_Mouse2.12698827
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08574170
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.06032558
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.06032558
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.04382740
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.03242088
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03018148
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01133499
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99680735
31* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.99667577
32* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.97665879
33ELK1_19687146_ChIP-ChIP_HELA_Human1.94889609
34* NANOG_18555785_Chip-Seq_ESCs_Mouse1.94464815
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.93533652
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93133393
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91986435
38* P53_22387025_ChIP-Seq_ESCs_Mouse1.91449113
39* E2F1_18555785_Chip-Seq_ESCs_Mouse1.91160947
40SOX2_20726797_ChIP-Seq_SW620_Human1.86764268
41* STAT3_18555785_Chip-Seq_ESCs_Mouse1.86108496
42* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.85960631
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.85721603
44IGF1R_20145208_ChIP-Seq_DFB_Human1.83725466
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82468562
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80395359
47* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77552199
48AHR_22903824_ChIP-Seq_MCF-7_Human1.76528114
49* NMYC_18555785_Chip-Seq_ESCs_Mouse1.76422319
50* CMYC_18555785_Chip-Seq_ESCs_Mouse1.74717235
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.74652926
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.74448952
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73831792
54* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73586901
55VDR_24787735_ChIP-Seq_THP-1_Human1.73222107
56* P300_18555785_Chip-Seq_ESCs_Mouse1.71456320
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71214309
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71119505
59TAF15_26573619_Chip-Seq_HEK293_Human1.71028821
60* P300_19829295_ChIP-Seq_ESCs_Human1.70655825
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69957880
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67956964
63* OCT4_18555785_Chip-Seq_ESCs_Mouse1.66889431
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.66837496
65* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.66520801
66BRD4_25478319_ChIP-Seq_HGPS_Human1.65611396
67TP53_16413492_ChIP-PET_HCT116_Human1.63616281
68* CDX2_22108803_ChIP-Seq_LS180_Human1.63074711
69* PU1_27457419_Chip-Seq_LIVER_Mouse1.62082136
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61466599
71* PIAS1_25552417_ChIP-Seq_VCAP_Human1.60841226
72* SOX2_18555785_Chip-Seq_ESCs_Mouse1.59963613
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57862342
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.57287078
75* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.56731672
76* ZFX_18555785_Chip-Seq_ESCs_Mouse1.56678313
77* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.55034664
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.54588571
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53048203
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52946902
81* KLF4_18555785_Chip-Seq_ESCs_Mouse1.52755338
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51605255
83* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.51186929
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50647276
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48609741
86* CTCF_18555785_Chip-Seq_ESCs_Mouse1.48603407
87* CRX_20693478_ChIP-Seq_RETINA_Mouse1.48153138
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.48043878
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47739244
90* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.46598874
91* GATA4_25053715_ChIP-Seq_YYC3_Human1.45366577
92FUS_26573619_Chip-Seq_HEK293_Human1.44614031
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42163993
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.41402973
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39575486
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.39323067
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38321888
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38321888
99TP53_18474530_ChIP-ChIP_U2OS_Human1.37259786
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36456599
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.36320749
102* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.36112806
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36075974
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36053158
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35925986
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.35344774
107EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35290703
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34585677
109* STAT3_23295773_ChIP-Seq_U87_Human1.34580230
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34503873
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34503873
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.34433249
113TFEB_21752829_ChIP-Seq_HELA_Human1.34007829
114VDR_22108803_ChIP-Seq_LS180_Human1.33246721
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.33056081
116EWS_26573619_Chip-Seq_HEK293_Human1.32912230
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32752238
118ELF5_23300383_ChIP-Seq_T47D_Human1.32612835
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32425065
120ER_23166858_ChIP-Seq_MCF-7_Human1.30843916
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29571493
122RNF2_27304074_Chip-Seq_NSC_Mouse1.29257980
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26972954
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26270227
125GABP_17652178_ChIP-ChIP_JURKAT_Human1.26253879
126* KDM2B_26808549_Chip-Seq_REH_Human1.25368641
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25321790
128CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24283168
129* TCF4_23295773_ChIP-Seq_U87_Human1.23888171
130DROSHA_22980978_ChIP-Seq_HELA_Human1.22802518
131* GATA6_25053715_ChIP-Seq_YYC3_Human1.21311368
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21071562
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20823223
134NANOG_19829295_ChIP-Seq_ESCs_Human1.19697422
135SOX2_19829295_ChIP-Seq_ESCs_Human1.19697422
136RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19435921
137EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19435921
138JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18774216
139RNF2_27304074_Chip-Seq_ESCs_Mouse1.17052265
140RUNX2_22187159_ChIP-Seq_PCA_Human1.15462369
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15042550
142TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14799651
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13726667
144TP63_23658742_ChIP-Seq_EP156T_Human1.13660185
145AR_25329375_ChIP-Seq_VCAP_Human1.13547625
146AR_21572438_ChIP-Seq_LNCaP_Human1.11346529
147* GATA3_24758297_ChIP-Seq_MCF-7_Human1.10968711
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10166076
149EZH2_27294783_Chip-Seq_ESCs_Mouse1.08757122
150ARNT_22903824_ChIP-Seq_MCF-7_Human1.06906811
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06096090
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05690849
153SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04985212
154IRF8_22096565_ChIP-ChIP_GC-B_Human1.04766046
155* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04688746
156NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04263245
157BCAT_22108803_ChIP-Seq_LS180_Human1.03659460
158HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02505665
159STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02477994
160CBP_20019798_ChIP-Seq_JUKART_Human1.01826798
161IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01826798
162CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01017583
163CBP_21632823_ChIP-Seq_H3396_Human1.00105888
164KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97971168
165SALL4_22934838_ChIP-ChIP_CD34+_Human0.97845160
166PHF8_20622853_ChIP-Seq_HELA_Human0.97461654
167HNFA_21074721_ChIP-Seq_CACO-2_Human0.96645899
168MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96429024
169TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96148424
170EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95808529
171KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95772584
172ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95616539
173GATA3_26560356_Chip-Seq_TH2_Human0.94929559
174FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94714537
175SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92767609
176ZNF274_21170338_ChIP-Seq_K562_Hela0.92495687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.27873975
2MP0001188_hyperpigmentation4.88832418
3MP0000569_abnormal_digit_pigmentation4.71416818
4MP0003950_abnormal_plasma_membrane4.51229450
5MP0003828_pulmonary_edema3.66192394
6MP0006082_CNS_inflammation3.40445946
7MP0000566_synostosis3.34910716
8MP0003136_yellow_coat_color3.14058501
9MP0005464_abnormal_platelet_physiology3.11654980
10MP0002102_abnormal_ear_morphology3.03994782
11MP0000015_abnormal_ear_pigmentation2.92528940
12MP0006292_abnormal_olfactory_placode2.72552888
13MP0005174_abnormal_tail_pigmentation2.69936914
14MP0005409_darkened_coat_color2.67525235
15MP0003195_calcinosis2.58022585
16MP0004381_abnormal_hair_follicle2.48982459
17MP0003252_abnormal_bile_duct2.38002826
18MP0002277_abnormal_respiratory_mucosa2.34434835
19MP0005645_abnormal_hypothalamus_physiol2.32574145
20MP0003787_abnormal_imprinting2.26064884
21MP0005171_absent_coat_pigmentation2.21679076
22MP0005164_abnormal_response_to2.19671548
23MP0003183_abnormal_peptide_metabolism2.18468086
24MP0000383_abnormal_hair_follicle2.18312238
25MP0005084_abnormal_gallbladder_morpholo2.15335176
26MP0003941_abnormal_skin_development2.14297609
27MP0001986_abnormal_taste_sensitivity2.13479982
28MP0005410_abnormal_fertilization2.01474071
29MP0000579_abnormal_nail_morphology1.99240677
30MP0008058_abnormal_DNA_repair1.82966480
31MP0005646_abnormal_pituitary_gland1.82135986
32MP0005451_abnormal_body_composition1.78151565
33MP0003453_abnormal_keratinocyte_physiol1.72428454
34MP0002095_abnormal_skin_pigmentation1.61942956
35MP0002332_abnormal_exercise_endurance1.56547732
36MP0000427_abnormal_hair_cycle1.56013367
37MP0002876_abnormal_thyroid_physiology1.54818986
38MP0002796_impaired_skin_barrier1.53226061
39MP0000685_abnormal_immune_system1.51994776
40MP0003221_abnormal_cardiomyocyte_apopto1.51416829
41MP0009697_abnormal_copulation1.50625013
42MP0004742_abnormal_vestibular_system1.48483273
43MP0001486_abnormal_startle_reflex1.48224371
44MP0003638_abnormal_response/metabolism_1.44598281
45MP0000343_altered_response_to1.41113879
46MP0005165_increased_susceptibility_to1.40962346
47MP0008260_abnormal_autophagy1.40761222
48MP0000762_abnormal_tongue_morphology1.40438006
49MP0005408_hypopigmentation1.39109093
50MP0004947_skin_inflammation1.37096205
51MP0000465_gastrointestinal_hemorrhage1.36381054
52MP0005670_abnormal_white_adipose1.35689622
53MP0002735_abnormal_chemical_nociception1.34656564
54MP0005075_abnormal_melanosome_morpholog1.34360664
55MP0002396_abnormal_hematopoietic_system1.32595603
56MP0000678_abnormal_parathyroid_gland1.32029180
57MP0000026_abnormal_inner_ear1.31715782
58MP0009379_abnormal_foot_pigmentation1.31512915
59MP0005360_urolithiasis1.30821077
60MP0001835_abnormal_antigen_presentation1.30500162
61MP0000627_abnormal_mammary_gland1.30423228
62MP0001216_abnormal_epidermal_layer1.29866867
63MP0009764_decreased_sensitivity_to1.28616315
64MP0005503_abnormal_tendon_morphology1.28395560
65MP0003879_abnormal_hair_cell1.28287490
66MP0005387_immune_system_phenotype1.27597217
67MP0001790_abnormal_immune_system1.27597217
68MP0000230_abnormal_systemic_arterial1.27293946
69MP0003045_fibrosis1.27089910
70MP0002148_abnormal_hypersensitivity_rea1.26838267
71MP0001346_abnormal_lacrimal_gland1.25516531
72MP0001853_heart_inflammation1.24528412
73MP0004272_abnormal_basement_membrane1.22659768
74MP0001666_abnormal_nutrient_absorption1.22654746
75MP0003091_abnormal_cell_migration1.20690080
76MP0010386_abnormal_urinary_bladder1.18072826
77MP0008995_early_reproductive_senescence1.17925753
78MP0004808_abnormal_hematopoietic_stem1.17762466
79MP0003868_abnormal_feces_composition1.17577721
80MP0003186_abnormal_redox_activity1.17474266
81MP0000490_abnormal_crypts_of1.17017225
82MP0005379_endocrine/exocrine_gland_phen1.14914701
83MP0001905_abnormal_dopamine_level1.13151772
84MP0005023_abnormal_wound_healing1.10480079
85MP0001764_abnormal_homeostasis1.08865751
86MP0003724_increased_susceptibility_to1.07757093
87MP0009046_muscle_twitch1.06907936
88MP0002938_white_spotting1.06855179
89MP0004134_abnormal_chest_morphology1.06709172
90MP0000467_abnormal_esophagus_morphology1.05888545
91MP0001502_abnormal_circadian_rhythm1.04723291
92MP0002638_abnormal_pupillary_reflex1.04664308
93MP0001984_abnormal_olfaction1.04047055
94MP0005257_abnormal_intraocular_pressure1.03126645
95MP0001963_abnormal_hearing_physiology1.02674283
96MP0000858_altered_metastatic_potential1.00980759
97MP0005647_abnormal_sex_gland1.00657481
98MP0001756_abnormal_urination1.00320853
99MP0002419_abnormal_innate_immunity1.00290593
100MP0009785_altered_susceptibility_to0.99987289
101MP0002177_abnormal_outer_ear0.99785183
102MP0008875_abnormal_xenobiotic_pharmacok0.99536645
103MP0002928_abnormal_bile_duct0.99298389
104MP0001851_eye_inflammation0.97879133
105MP0000371_diluted_coat_color0.97799579
106MP0003936_abnormal_reproductive_system0.97723974
107MP0001186_pigmentation_phenotype0.97030494
108MP0005551_abnormal_eye_electrophysiolog0.95468808
109MP0010678_abnormal_skin_adnexa0.95421904
110MP0002138_abnormal_hepatobiliary_system0.94680060
111MP0001765_abnormal_ion_homeostasis0.94069744
112MP0004019_abnormal_vitamin_homeostasis0.93329182
113MP0002136_abnormal_kidney_physiology0.92304352
114MP0002693_abnormal_pancreas_physiology0.91917576
115MP0010155_abnormal_intestine_physiology0.91170871
116MP0009250_abnormal_appendicular_skeleto0.90779369
117MP0001881_abnormal_mammary_gland0.89885890
118MP0004883_abnormal_blood_vessel0.89248017
119MP0002736_abnormal_nociception_after0.88738850
120MP0002972_abnormal_cardiac_muscle0.88174252
121MP0002249_abnormal_larynx_morphology0.87740124
122MP0001800_abnormal_humoral_immune0.87216986
123MP0002075_abnormal_coat/hair_pigmentati0.86840534
124MP0005332_abnormal_amino_acid0.86059299
125MP0000749_muscle_degeneration0.85731648
126MP0002139_abnormal_hepatobiliary_system0.84841960
127MP0002998_abnormal_bone_remodeling0.84189087
128MP0003938_abnormal_ear_development0.83661072
129MP0001968_abnormal_touch/_nociception0.83095049
130MP0008877_abnormal_DNA_methylation0.82579653
131MP0008872_abnormal_physiological_respon0.82092524
132MP0009643_abnormal_urine_homeostasis0.81863087
133MP0000372_irregular_coat_pigmentation0.81582728
134MP0005025_abnormal_response_to0.80443835
135MP0002233_abnormal_nose_morphology0.80042766
136MP0002723_abnormal_immune_serum0.79473812
137MP0005671_abnormal_response_to0.78942212
138MP0000470_abnormal_stomach_morphology0.78024893
139MP0002452_abnormal_antigen_presenting0.77785398
140MP0002132_abnormal_respiratory_system0.77615910
141MP0005376_homeostasis/metabolism_phenot0.77544120
142MP0005501_abnormal_skin_physiology0.77372151
143MP0002254_reproductive_system_inflammat0.76712130
144MP0009763_increased_sensitivity_to0.76390983
145MP0003718_maternal_effect0.75940505
146MP0002067_abnormal_sensory_capabilities0.75507193
147MP0002009_preneoplasia0.75308367
148MP0001873_stomach_inflammation0.75087786
149MP0001845_abnormal_inflammatory_respons0.74280513
150MP0002098_abnormal_vibrissa_morphology0.73501184
151MP0000538_abnormal_urinary_bladder0.73472301
152MP0002163_abnormal_gland_morphology0.73350193
153MP0004264_abnormal_extraembryonic_tissu0.72456580
154MP0000681_abnormal_thyroid_gland0.71443036
155MP0002060_abnormal_skin_morphology0.71037857
156MP0009780_abnormal_chondrocyte_physiolo0.70823578
157MP0006054_spinal_hemorrhage0.70123074
158MP0002109_abnormal_limb_morphology0.69719758
159MP0001191_abnormal_skin_condition0.69705509
160MP0001944_abnormal_pancreas_morphology0.68779467
161MP0001324_abnormal_eye_pigmentation0.68445859
162MP0005220_abnormal_exocrine_pancreas0.67945237
163MP0005666_abnormal_adipose_tissue0.67914380
164MP0005253_abnormal_eye_physiology0.67345914
165MP0006036_abnormal_mitochondrial_physio0.67320311
166MP0000747_muscle_weakness0.65820853
167MP0005000_abnormal_immune_tolerance0.65621397
168MP0000049_abnormal_middle_ear0.63940534
169MP0004782_abnormal_surfactant_physiolog0.62782776
170MP0008004_abnormal_stomach_pH0.61306864
171MP0002557_abnormal_social/conspecific_i0.61242975
172MP0002168_other_aberrant_phenotype0.60395853
173MP0004142_abnormal_muscle_tone0.60231829
174MP0001501_abnormal_sleep_pattern0.59809025
175MP0001119_abnormal_female_reproductive0.59494675

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.43867006
2Hypokinesia (HP:0002375)6.28440651
3Axonal loss (HP:0003447)5.88055865
4Chromsome breakage (HP:0040012)5.79680260
5Neonatal respiratory distress (HP:0002643)5.71873209
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.06909366
7Hyporeflexia of lower limbs (HP:0002600)4.81654112
8Alopecia of scalp (HP:0002293)4.45765616
9Prostate neoplasm (HP:0100787)4.38833670
10Abnormality of dental color (HP:0011073)4.06247522
11Amelogenesis imperfecta (HP:0000705)4.05551152
12Upper limb muscle weakness (HP:0003484)3.94972720
13Dyschromatopsia (HP:0007641)3.89938086
14Diaphragmatic weakness (HP:0009113)3.74787907
15Muscle fiber splitting (HP:0003555)3.68710448
16Abnormality of the frontal sinuses (HP:0002687)3.64444322
17Disinhibition (HP:0000734)3.58551080
18Mutism (HP:0002300)3.51085145
19Duplicated collecting system (HP:0000081)3.30883630
20Diminished movement (HP:0002374)3.20008625
21Abnormality of the renal collecting system (HP:0004742)3.17990193
22Cavernous hemangioma (HP:0001048)3.06427352
23Congenital stationary night blindness (HP:0007642)3.05273718
24Abnormality of proline metabolism (HP:0010907)3.04129318
25Hydroxyprolinuria (HP:0003080)3.04129318
26Neck muscle weakness (HP:0000467)2.97032726
27Hypophosphatemic rickets (HP:0004912)2.93418005
28Fragile nails (HP:0001808)2.86833332
29Abnormality of the vasculature of the conjunctiva (HP:0008054)2.82272806
30Prolonged bleeding time (HP:0003010)2.81875025
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.81057104
32Renal cortical cysts (HP:0000803)2.80629181
33Tubulointerstitial nephritis (HP:0001970)2.79855025
34Conjunctival telangiectasia (HP:0000524)2.79624718
35Choroideremia (HP:0001139)2.77486598
36Clubbing of toes (HP:0100760)2.76578716
37Septo-optic dysplasia (HP:0100842)2.76285024
38Nuclear cataract (HP:0100018)2.75006501
39Distal lower limb muscle weakness (HP:0009053)2.73327902
40Mesomelia (HP:0003027)2.71540176
41J-shaped sella turcica (HP:0002680)2.71446237
42Abnormality of incisor morphology (HP:0011063)2.68789481
43Oral leukoplakia (HP:0002745)2.68127204
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.68072842
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.67086163
46Absent/shortened dynein arms (HP:0200106)2.67086163
47Autoimmune hemolytic anemia (HP:0001890)2.66747760
48Abnormal ciliary motility (HP:0012262)2.61926890
49Abnormality of the preputium (HP:0100587)2.60954994
50Congenital sensorineural hearing impairment (HP:0008527)2.57823432
51EMG: myopathic abnormalities (HP:0003458)2.57441666
52Follicular hyperkeratosis (HP:0007502)2.56653848
53Abnormality of DNA repair (HP:0003254)2.56142054
54Distal lower limb amyotrophy (HP:0008944)2.55688992
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.53915034
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.53915034
57Acute myeloid leukemia (HP:0004808)2.52818339
58White forelock (HP:0002211)2.52439693
59Abnormality of the prostate (HP:0008775)2.52126297
60Metaphyseal dysplasia (HP:0100255)2.51583405
61Chronic hepatic failure (HP:0100626)2.51189262
62Decreased central vision (HP:0007663)2.50711640
63Mitral stenosis (HP:0001718)2.50120620
64Meckel diverticulum (HP:0002245)2.50081303
65Arterial tortuosity (HP:0005116)2.49853828
66Aplasia cutis congenita (HP:0001057)2.44350397
67Knee flexion contracture (HP:0006380)2.44195760
68Testicular neoplasm (HP:0010788)2.43200863
69Retrobulbar optic neuritis (HP:0100654)2.42414532
70Optic neuritis (HP:0100653)2.42414532
71Hip dysplasia (HP:0001385)2.41894824
72Abnormality of the ileum (HP:0001549)2.39836676
73Petechiae (HP:0000967)2.39268639
74Tetraparesis (HP:0002273)2.37065807
75Abnormality of the nasal septum (HP:0000419)2.36745901
76Patchy hypopigmentation of hair (HP:0011365)2.34725786
77Vacuolated lymphocytes (HP:0001922)2.32436595
78Abnormality of chromosome stability (HP:0003220)2.31083606
79Exocrine pancreatic insufficiency (HP:0001738)2.30819285
80Osteomalacia (HP:0002749)2.28801394
81Hypothermia (HP:0002045)2.26938053
82Ectopic kidney (HP:0000086)2.24056550
83Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23007629
84Cranial hyperostosis (HP:0004437)2.22915256
85Tubular atrophy (HP:0000092)2.22384607
86Fair hair (HP:0002286)2.22117135
87Lip pit (HP:0100267)2.21597727
88Menorrhagia (HP:0000132)2.21556561
89Abnormal respiratory motile cilium physiology (HP:0012261)2.16850152
90Inappropriate behavior (HP:0000719)2.16708855
91Craniofacial hyperostosis (HP:0004493)2.15019777
92Aplasia/Hypoplasia of the scapulae (HP:0006713)2.13746445
93Hypoplastic scapulae (HP:0000882)2.13746445
94Abnormality of the carotid arteries (HP:0005344)2.13598131
95Abnormality of lateral ventricle (HP:0030047)2.13552582
96Alveolar cell carcinoma (HP:0006519)2.13016158
97Rapidly progressive (HP:0003678)2.12976215
98Protruding tongue (HP:0010808)2.11725446
99Sparse lateral eyebrow (HP:0005338)2.11052847
100Corneal dystrophy (HP:0001131)2.09419722
101Congenital hepatic fibrosis (HP:0002612)2.08092060
102Abnormality of the renal cortex (HP:0011035)2.08016242
103Abnormality of the common coagulation pathway (HP:0010990)2.05230404
104Widely spaced teeth (HP:0000687)2.05148025
105Submucous cleft hard palate (HP:0000176)2.04891433
106Microvesicular hepatic steatosis (HP:0001414)2.03438181
107Optic nerve hypoplasia (HP:0000609)2.02886474
108True hermaphroditism (HP:0010459)2.02001558
109Wide intermamillary distance (HP:0006610)2.01596221
110Conjunctival hamartoma (HP:0100780)1.99777537
111Impaired platelet aggregation (HP:0003540)1.98960102
112Abnormal platelet function (HP:0011869)1.98960102
113Lower limb amyotrophy (HP:0007210)1.98944306
114Abnormality of the renal medulla (HP:0100957)1.98550507
115Vascular tortuosity (HP:0004948)1.98066689
116Median cleft lip (HP:0000161)1.97624402
117Duplication of thumb phalanx (HP:0009942)1.93604142
118Increased mean platelet volume (HP:0011877)1.93541635
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93116789
120Generalized hypopigmentation of hair (HP:0011358)1.92664389
121External ophthalmoplegia (HP:0000544)1.92230189
122Abnormality of the axillary hair (HP:0100134)1.91311322
123Abnormality of secondary sexual hair (HP:0009888)1.91311322
124Generalized amyotrophy (HP:0003700)1.89571800
125Mediastinal lymphadenopathy (HP:0100721)1.89502285
126Chronic diarrhea (HP:0002028)1.88738645
127Nephronophthisis (HP:0000090)1.87899907
128Nephrogenic diabetes insipidus (HP:0009806)1.87689068
129Abnormality of permanent molar morphology (HP:0011071)1.87250501
130Abnormality of the dental root (HP:0006486)1.87250501
131Taurodontia (HP:0000679)1.87250501
132Recurrent cutaneous fungal infections (HP:0011370)1.86382516
133Chronic mucocutaneous candidiasis (HP:0002728)1.86382516
134Focal motor seizures (HP:0011153)1.86241975
135Neoplasm of the tracheobronchial system (HP:0100552)1.85929678
136Nephroblastoma (Wilms tumor) (HP:0002667)1.85873899
137Abnormality of the anterior horn cell (HP:0006802)1.84466013
138Degeneration of anterior horn cells (HP:0002398)1.84466013
139Polar cataract (HP:0010696)1.84360137
140Malnutrition (HP:0004395)1.82887459
141Keratoconus (HP:0000563)1.82719587
142Increased corneal curvature (HP:0100692)1.82719587
143Postaxial foot polydactyly (HP:0001830)1.82701739
144Absent hand (HP:0004050)1.82155805
145Abnormal respiratory epithelium morphology (HP:0012253)1.81842553
146Abnormal respiratory motile cilium morphology (HP:0005938)1.81842553
147Gingivitis (HP:0000230)1.80899992
148Aplasia/Hypoplasia of the fovea (HP:0008060)1.80826832
149Hypoplasia of the fovea (HP:0007750)1.80826832
150Recurrent pneumonia (HP:0006532)1.80749024
151Absent frontal sinuses (HP:0002688)1.80321545
152Male pseudohermaphroditism (HP:0000037)1.80243596
153Loss of speech (HP:0002371)1.79974843
154Congenital ichthyosiform erythroderma (HP:0007431)1.78457591
155Hoarse voice (HP:0001609)1.78031637
156Recurrent abscess formation (HP:0002722)1.77991366
157Severe muscular hypotonia (HP:0006829)1.77445278
158Eczematoid dermatitis (HP:0000976)1.76739972
159Sparse eyelashes (HP:0000653)1.76004453
160Premature loss of primary teeth (HP:0006323)1.75630509
161Zonular cataract (HP:0010920)1.75557318
162Thick nail (HP:0001805)1.75548869
163Nasal speech (HP:0001611)1.75405827
164Abnormality of the columella (HP:0009929)1.74618005
165Abnormality of the corticospinal tract (HP:0002492)1.74356491
166Conical tooth (HP:0000698)1.74124136
167Embryonal renal neoplasm (HP:0011794)1.73551971
168Azoospermia (HP:0000027)1.73130554
169Abnormality of the parietal bone (HP:0002696)1.72721878
170* Febrile seizures (HP:0002373)1.72580058
171Autoimmune thrombocytopenia (HP:0001973)1.72373459
172Aplasia/Hypoplasia of the tibia (HP:0005772)1.72363376
173Abnormality of the dental pulp (HP:0006479)1.72041173
174Epistaxis (HP:0000421)1.71133691
175Cerebral hemorrhage (HP:0001342)1.69418952
176Pulmonary artery stenosis (HP:0004415)1.69242722
177Renal tubular acidosis (HP:0001947)1.68687995
178Abnormality of primary teeth (HP:0006481)1.65810763
179Abnormality of male internal genitalia (HP:0000022)1.64845043
180Orchitis (HP:0100796)1.63923150
181Preaxial hand polydactyly (HP:0001177)1.63516797
182Stomach cancer (HP:0012126)1.62376767
183Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59986698
184Anal stenosis (HP:0002025)1.58670534
185Oligohydramnios (HP:0001562)1.56978099
186Joint hemorrhage (HP:0005261)1.56864401
187Attenuation of retinal blood vessels (HP:0007843)1.56738342
188Abnormality of the incisor (HP:0000676)1.56457370
189Conjugated hyperbilirubinemia (HP:0002908)1.54940260
190Abnormal hair whorl (HP:0010721)1.54585976
191Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.53867818
192Medial flaring of the eyebrow (HP:0010747)1.53450987
193Short thumb (HP:0009778)1.53400788
194Hypergonadotropic hypogonadism (HP:0000815)1.53174560
195Small intestinal stenosis (HP:0012848)1.52668597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.20770904
2TRIM284.20391540
3CASK3.83199085
4LATS23.37501338
5MST43.36721999
6TNIK3.06976181
7INSRR3.04589094
8EIF2AK23.02644560
9ZAK2.90113304
10TXK2.87803152
11MYLK2.76453489
12STK392.74331358
13MAP3K142.55188192
14STK162.44535070
15IRAK32.40966730
16PDK22.26777376
17GRK12.14027135
18ARAF2.03845059
19KSR12.03559716
20MAP3K91.99042134
21IRAK41.88705425
22EIF2AK31.76016790
23YES11.73670440
24PRPF4B1.66039688
25EIF2AK11.65298485
26BRD41.63286417
27WNK41.60679205
28MAP2K71.60106382
29SIK31.59955559
30ADRBK21.56087391
31OXSR11.55109309
32MAP3K31.48796364
33SGK21.47630138
34NUAK11.45112800
35NTRK31.44645993
36NEK61.44339467
37MKNK21.42180948
38TGFBR21.38850409
39MUSK1.37719699
40TEC1.32656096
41EPHA21.27384002
42PIK3CG1.26897712
43MST1R1.25622437
44BMPR21.21683760
45JAK11.18713334
46CAMK1D1.18332370
47DYRK31.17090044
48MOS1.16585513
49BMPR1B1.16313179
50ACVR1B1.15747977
51IKBKB1.15393963
52EPHA31.14117609
53TAOK31.12103718
54RAF11.11002485
55IKBKE1.09539546
56PKN11.06025383
57CDK31.05491308
58SRPK11.05230958
59MAPK131.05078298
60CAMK1G1.03681476
61LATS11.03240546
62TNK21.02748184
63MAP3K131.01974141
64GRK71.00628557
65IRAK10.98811509
66RIPK40.98385878
67FRK0.96374636
68STK38L0.95797831
69ILK0.95556893
70KIT0.93109246
71AKT30.92248309
72SIK20.85808544
73BLK0.84200795
74MAP2K10.83548151
75JAK30.82834414
76CHUK0.82794692
77CLK10.80874968
78PIK3CA0.80131909
79MKNK10.78374045
80SGK30.78358115
81TAF10.77334373
82TAOK20.75510685
83CSF1R0.75117799
84SGK10.74012163
85PRKCE0.73652338
86NLK0.71782603
87MAPK70.71138730
88FGFR10.71127988
89PRKAA20.70624823
90TRPM70.69106188
91SGK2230.69063053
92SGK4940.69063053
93PAK40.67783946
94MET0.67102275
95IRAK20.65358293
96LYN0.63878771
97NTRK20.61933657
98HCK0.61147639
99STK30.59427170
100PLK40.58925637
101CAMK2G0.58309663
102ATR0.57542804
103CAMK10.56819391
104STK240.56745665
105TESK20.56128864
106EPHB20.55975796
107MAPKAPK30.55935485
108CDK120.55827776
109MAPKAPK20.55478832
110MAP3K20.54944907
111OBSCN0.54278388
112CDK90.54043678
113MARK30.53414801
114PLK20.52601859
115BRSK20.52225257
116PAK10.50415063
117PTK2B0.48639499
118SIK10.48188510
119CDC42BPA0.47820739
120PRKG10.47605958
121EPHA40.47068784
122CAMK40.46847303
123PIM20.46103668
124ADRBK10.46065787
125PDGFRB0.45947543
126ERBB30.44626579
127PINK10.44177442
128AKT20.43191809
129STK110.42961177
130PRKCQ0.41435184
131LCK0.40524507
132SYK0.40319613
133TIE10.39170052
134KSR20.38892818
135FGFR30.38709649
136TBK10.38398295
137STK40.37542471
138FES0.37245513
139CDK80.36384191
140ABL20.35552906
141DAPK10.35215804
142DDR20.34502720
143ERBB40.34427903
144AKT10.34170831
145CAMK2A0.34043159
146DMPK0.33608838
147ATM0.33040217
148MAP2K60.32538275
149BCR0.32468802
150BTK0.32459073
151PBK0.30510319
152ROCK10.29180105
153FER0.26214388
154PNCK0.25115620
155ABL10.24673506
156PTK20.23724072
157MINK10.22695074
158STK380.22529359
159GSK3A0.20161416
160PRKCD0.19992229
161PRKCI0.19717255
162WEE10.18221774
163LMTK20.17948517

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.65481393
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.15508866
3Legionellosis_Homo sapiens_hsa051342.66138809
4Fanconi anemia pathway_Homo sapiens_hsa034602.48214101
5Basal transcription factors_Homo sapiens_hsa030222.40419291
6Nicotine addiction_Homo sapiens_hsa050332.19851937
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.07997625
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03966729
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.02701201
10Caffeine metabolism_Homo sapiens_hsa002322.01531452
11Phototransduction_Homo sapiens_hsa047441.98390886
12Vibrio cholerae infection_Homo sapiens_hsa051101.92989938
13Protein export_Homo sapiens_hsa030601.91944926
14Non-homologous end-joining_Homo sapiens_hsa034501.87752357
15Graft-versus-host disease_Homo sapiens_hsa053321.85450008
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82417834
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80142670
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.76463863
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74953084
20Proteasome_Homo sapiens_hsa030501.72304940
21Hematopoietic cell lineage_Homo sapiens_hsa046401.70325383
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65880357
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65427770
24Allograft rejection_Homo sapiens_hsa053301.62845225
25Taste transduction_Homo sapiens_hsa047421.59519611
26Autoimmune thyroid disease_Homo sapiens_hsa053201.58175231
27Sphingolipid metabolism_Homo sapiens_hsa006001.55458657
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53902637
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52698288
30Vitamin digestion and absorption_Homo sapiens_hsa049771.48268096
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48107914
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46644511
33ABC transporters_Homo sapiens_hsa020101.43862409
34Platelet activation_Homo sapiens_hsa046111.43831034
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42433581
36Measles_Homo sapiens_hsa051621.40131814
37Morphine addiction_Homo sapiens_hsa050321.34822177
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34558793
39Homologous recombination_Homo sapiens_hsa034401.29224024
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27574721
41Rheumatoid arthritis_Homo sapiens_hsa053231.26595891
42Glutathione metabolism_Homo sapiens_hsa004801.26565504
43Primary immunodeficiency_Homo sapiens_hsa053401.24082949
44Malaria_Homo sapiens_hsa051441.23398629
45Shigellosis_Homo sapiens_hsa051311.21765951
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19505077
47Arachidonic acid metabolism_Homo sapiens_hsa005901.16330168
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16325948
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13500561
50Folate biosynthesis_Homo sapiens_hsa007901.11410703
51Asthma_Homo sapiens_hsa053101.10044813
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.08810217
53FoxO signaling pathway_Homo sapiens_hsa040681.08258202
54Arginine and proline metabolism_Homo sapiens_hsa003301.07624746
55Calcium signaling pathway_Homo sapiens_hsa040201.06801363
56Pertussis_Homo sapiens_hsa051331.05488259
57Prion diseases_Homo sapiens_hsa050201.05057995
58Sulfur metabolism_Homo sapiens_hsa009201.04647107
59TNF signaling pathway_Homo sapiens_hsa046681.02720348
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00041461
61Salmonella infection_Homo sapiens_hsa051320.98490645
62Ovarian steroidogenesis_Homo sapiens_hsa049130.98432690
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97834720
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.96916790
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.96183948
66Fructose and mannose metabolism_Homo sapiens_hsa000510.96135762
67Pancreatic cancer_Homo sapiens_hsa052120.91748928
68Olfactory transduction_Homo sapiens_hsa047400.91033321
69Other glycan degradation_Homo sapiens_hsa005110.90468292
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.90193290
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90114274
72Serotonergic synapse_Homo sapiens_hsa047260.89932236
73Selenocompound metabolism_Homo sapiens_hsa004500.89882958
74Inositol phosphate metabolism_Homo sapiens_hsa005620.88674213
75African trypanosomiasis_Homo sapiens_hsa051430.88468414
76Herpes simplex infection_Homo sapiens_hsa051680.87848994
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87516644
78Lysine degradation_Homo sapiens_hsa003100.87176301
79Osteoclast differentiation_Homo sapiens_hsa043800.86955159
80Influenza A_Homo sapiens_hsa051640.86858014
81Retinol metabolism_Homo sapiens_hsa008300.86444972
82Ether lipid metabolism_Homo sapiens_hsa005650.86264080
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.86178045
84Hepatitis B_Homo sapiens_hsa051610.85944589
85Amoebiasis_Homo sapiens_hsa051460.85022287
86Leishmaniasis_Homo sapiens_hsa051400.84972864
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84801412
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84695159
89Glutamatergic synapse_Homo sapiens_hsa047240.84504623
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81483544
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78541588
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78500491
93Renal cell carcinoma_Homo sapiens_hsa052110.78229122
94beta-Alanine metabolism_Homo sapiens_hsa004100.77237328
95Staphylococcus aureus infection_Homo sapiens_hsa051500.77172822
96ECM-receptor interaction_Homo sapiens_hsa045120.76580812
97Chemokine signaling pathway_Homo sapiens_hsa040620.76236660
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75596323
99Galactose metabolism_Homo sapiens_hsa000520.74992844
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73782689
101Linoleic acid metabolism_Homo sapiens_hsa005910.73560621
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73117119
103Basal cell carcinoma_Homo sapiens_hsa052170.72281835
104Collecting duct acid secretion_Homo sapiens_hsa049660.71433835
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70511891
106Type I diabetes mellitus_Homo sapiens_hsa049400.70201702
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68530534
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66610767
109Circadian rhythm_Homo sapiens_hsa047100.66295487
110cAMP signaling pathway_Homo sapiens_hsa040240.65793351
111Circadian entrainment_Homo sapiens_hsa047130.62692100
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62491217
113Starch and sucrose metabolism_Homo sapiens_hsa005000.61367560
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.60703776
115Chemical carcinogenesis_Homo sapiens_hsa052040.60170396
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59456356
117Endocytosis_Homo sapiens_hsa041440.57698826
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57683114
119Axon guidance_Homo sapiens_hsa043600.57165061
120Histidine metabolism_Homo sapiens_hsa003400.57008197
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56439142
122Tuberculosis_Homo sapiens_hsa051520.55834523
123Type II diabetes mellitus_Homo sapiens_hsa049300.55499097
124Phagosome_Homo sapiens_hsa041450.55279453
125TGF-beta signaling pathway_Homo sapiens_hsa043500.54999702
126Protein digestion and absorption_Homo sapiens_hsa049740.53836034
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51079367
128Melanoma_Homo sapiens_hsa052180.49995786
129Hepatitis C_Homo sapiens_hsa051600.49936461
130Insulin secretion_Homo sapiens_hsa049110.49910396
131p53 signaling pathway_Homo sapiens_hsa041150.49150575
132Salivary secretion_Homo sapiens_hsa049700.49052566
133Ras signaling pathway_Homo sapiens_hsa040140.48329034
134Pancreatic secretion_Homo sapiens_hsa049720.46937450
135Thyroid cancer_Homo sapiens_hsa052160.45810757
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45674912
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45080478
138Regulation of autophagy_Homo sapiens_hsa041400.44219554
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44084992
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43396035
141Small cell lung cancer_Homo sapiens_hsa052220.42257989
142T cell receptor signaling pathway_Homo sapiens_hsa046600.42247860
143Tyrosine metabolism_Homo sapiens_hsa003500.39587636
144Focal adhesion_Homo sapiens_hsa045100.39251528
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38586010
146Mineral absorption_Homo sapiens_hsa049780.38096760
147Systemic lupus erythematosus_Homo sapiens_hsa053220.37299660
148Apoptosis_Homo sapiens_hsa042100.36323980
149One carbon pool by folate_Homo sapiens_hsa006700.35740124
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35110274
151Toxoplasmosis_Homo sapiens_hsa051450.34330889
152Wnt signaling pathway_Homo sapiens_hsa043100.33406147
153Viral carcinogenesis_Homo sapiens_hsa052030.28617519
154B cell receptor signaling pathway_Homo sapiens_hsa046620.27912361

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »