CPAMD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)4.48826064
2otic vesicle formation (GO:0030916)4.46825095
3glomerular basement membrane development (GO:0032836)4.19382629
4limb bud formation (GO:0060174)4.15701269
5growth hormone receptor signaling pathway (GO:0060396)4.01864985
6prostate gland growth (GO:0060736)3.85921024
7behavioral response to nicotine (GO:0035095)3.73478386
8cornea development in camera-type eye (GO:0061303)3.64884318
9cellular response to growth hormone stimulus (GO:0071378)3.56038991
10negative regulation of Rho protein signal transduction (GO:0035024)3.42314621
11positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.30304416
12lateral sprouting from an epithelium (GO:0060601)3.29187368
13indole-containing compound catabolic process (GO:0042436)3.25233881
14indolalkylamine catabolic process (GO:0046218)3.25233881
15tryptophan catabolic process (GO:0006569)3.25233881
16kidney morphogenesis (GO:0060993)3.23153863
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.19606609
18detection of light stimulus involved in visual perception (GO:0050908)3.11938015
19detection of light stimulus involved in sensory perception (GO:0050962)3.11938015
20auditory receptor cell stereocilium organization (GO:0060088)3.07991695
21indolalkylamine metabolic process (GO:0006586)3.07382185
22regulation of activation of Janus kinase activity (GO:0010533)3.05143336
23mesonephros development (GO:0001823)3.03265106
24radial glial cell differentiation (GO:0060019)2.93727138
25fucose catabolic process (GO:0019317)2.92558084
26L-fucose metabolic process (GO:0042354)2.92558084
27L-fucose catabolic process (GO:0042355)2.92558084
28skeletal muscle adaptation (GO:0043501)2.86849612
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.85728104
30negative regulation of translation, ncRNA-mediated (GO:0040033)2.85728104
31regulation of translation, ncRNA-mediated (GO:0045974)2.85728104
32bicarbonate transport (GO:0015701)2.85658831
33lung secretory cell differentiation (GO:0061140)2.85091858
34phosphatidylinositol acyl-chain remodeling (GO:0036149)2.85073840
35kynurenine metabolic process (GO:0070189)2.84656113
36inner ear receptor stereocilium organization (GO:0060122)2.80596730
37regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.78384207
38negative regulation of systemic arterial blood pressure (GO:0003085)2.78336365
39cellular ketone body metabolic process (GO:0046950)2.77436800
40detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76144180
41epithelial cilium movement (GO:0003351)2.74197316
42axoneme assembly (GO:0035082)2.74017357
43tryptophan metabolic process (GO:0006568)2.73988100
44thyroid hormone metabolic process (GO:0042403)2.72378009
45sulfation (GO:0051923)2.71719612
46photoreceptor cell maintenance (GO:0045494)2.68919159
47regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.65804613
48reflex (GO:0060004)2.62635973
49negative regulation of actin filament bundle assembly (GO:0032232)2.61687884
50negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61348160
51negative regulation of mast cell activation (GO:0033004)2.57689909
52ketone body metabolic process (GO:1902224)2.56919644
53organ growth (GO:0035265)2.55529846
54urinary tract smooth muscle contraction (GO:0014848)2.54063814
55cilium or flagellum-dependent cell motility (GO:0001539)2.52940703
56white fat cell differentiation (GO:0050872)2.52323168
57G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50953708
58positive regulation of digestive system process (GO:0060456)2.50563789
59regulation of gene silencing by miRNA (GO:0060964)2.49659341
60regulation of gene silencing by RNA (GO:0060966)2.49659341
61regulation of posttranscriptional gene silencing (GO:0060147)2.49659341
62prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.49377987
63dendritic spine morphogenesis (GO:0060997)2.47937819
64nonmotile primary cilium assembly (GO:0035058)2.46576684
65cilium movement (GO:0003341)2.45214605
66thyroid hormone generation (GO:0006590)2.43443684
67regulation of memory T cell differentiation (GO:0043380)2.42759000
68amine catabolic process (GO:0009310)2.41334565
69cellular biogenic amine catabolic process (GO:0042402)2.41334565
70phasic smooth muscle contraction (GO:0014821)2.41148362
71indole-containing compound metabolic process (GO:0042430)2.40180296
72embryonic camera-type eye development (GO:0031076)2.39975322
73cilium morphogenesis (GO:0060271)2.39349871
74protein K11-linked deubiquitination (GO:0035871)2.38208526
75neuronal action potential (GO:0019228)2.34008358
76embryonic digestive tract morphogenesis (GO:0048557)2.33807015
77regulation of action potential (GO:0098900)2.33533435
78response to pheromone (GO:0019236)2.32924897
79preassembly of GPI anchor in ER membrane (GO:0016254)2.32533666
80somite development (GO:0061053)2.30729635
81cilium organization (GO:0044782)2.30322149
82positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.27182156
83dorsal/ventral axis specification (GO:0009950)2.26735972
84cilium assembly (GO:0042384)2.26643256
85lymphangiogenesis (GO:0001946)2.25497806
86phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.24896674
87one-carbon compound transport (GO:0019755)2.23437433
88positive regulation of protein kinase C signaling (GO:0090037)2.23314561
89visual perception (GO:0007601)2.23280425
90cAMP catabolic process (GO:0006198)2.23212812
91peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.22687417
92transepithelial transport (GO:0070633)2.22338385
93regulation of phospholipid biosynthetic process (GO:0071071)2.22319768
94head development (GO:0060322)2.22152776
95appendage development (GO:0048736)2.21758231
96limb development (GO:0060173)2.21758231
97photoreceptor cell development (GO:0042461)2.21695052
98metanephric nephron tubule development (GO:0072234)2.21154489
99metanephric tubule development (GO:0072170)2.21154489
100sensory perception of light stimulus (GO:0050953)2.20725730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.98299353
2ZNF274_21170338_ChIP-Seq_K562_Hela2.84034432
3GBX2_23144817_ChIP-Seq_PC3_Human2.80136192
4VDR_22108803_ChIP-Seq_LS180_Human2.70429507
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32642879
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.30651923
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14845486
8IGF1R_20145208_ChIP-Seq_DFB_Human1.96770226
9PIAS1_25552417_ChIP-Seq_VCAP_Human1.90623093
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89189892
11ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87102411
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82411885
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71741386
14* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68322410
15ER_23166858_ChIP-Seq_MCF-7_Human1.68114717
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64675122
17BCAT_22108803_ChIP-Seq_LS180_Human1.63826404
18AR_21572438_ChIP-Seq_LNCaP_Human1.61672176
19AHR_22903824_ChIP-Seq_MCF-7_Human1.61020625
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57586251
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56282041
22P300_19829295_ChIP-Seq_ESCs_Human1.55269969
23SMAD4_21799915_ChIP-Seq_A2780_Human1.52213009
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.51972880
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51776760
26TAF15_26573619_Chip-Seq_HEK293_Human1.51436758
27STAT3_23295773_ChIP-Seq_U87_Human1.50590432
28* DROSHA_22980978_ChIP-Seq_HELA_Human1.50552626
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49185652
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.49145572
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.49085753
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44392156
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44392156
34AR_25329375_ChIP-Seq_VCAP_Human1.44073476
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42859976
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42324890
37* TCF4_23295773_ChIP-Seq_U87_Human1.41219591
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40304631
39EWS_26573619_Chip-Seq_HEK293_Human1.38221573
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32930710
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.32796206
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31987617
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31072939
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27483699
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25911272
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.25381917
47FUS_26573619_Chip-Seq_HEK293_Human1.25093676
48TP53_16413492_ChIP-PET_HCT116_Human1.24678793
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22607111
50TCF4_22108803_ChIP-Seq_LS180_Human1.22060558
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22047349
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21998836
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21760001
54RUNX2_22187159_ChIP-Seq_PCA_Human1.21731091
55SMAD3_21741376_ChIP-Seq_HESCs_Human1.20622550
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.20271153
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.18435851
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17757234
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17715376
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16086031
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12170140
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11149575
63* HOXB7_26014856_ChIP-Seq_BT474_Human1.10463031
64SMAD4_21741376_ChIP-Seq_HESCs_Human1.09796937
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09519796
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.09250634
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08518459
68TP53_22573176_ChIP-Seq_HFKS_Human1.08209169
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.08040587
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08033430
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07799482
72CBP_20019798_ChIP-Seq_JUKART_Human1.07799482
73IRF1_19129219_ChIP-ChIP_H3396_Human1.07459116
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06202723
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05767219
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.05752566
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05477842
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05074252
79REST_21632747_ChIP-Seq_MESCs_Mouse1.04824634
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04796623
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03744926
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.03744926
83RXR_22108803_ChIP-Seq_LS180_Human1.03403076
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.02447503
85RNF2_27304074_Chip-Seq_NSC_Mouse1.02271063
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02132855
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00931873
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00557796
89SOX2_21211035_ChIP-Seq_LN229_Gbm0.99404147
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98155941
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97857141
92AR_20517297_ChIP-Seq_VCAP_Human0.97702487
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97240033
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96318837
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.96130036
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95287054
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95280244
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95209444
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95082021
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.94860631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.56958655
2MP0003878_abnormal_ear_physiology4.56958655
3MP0002102_abnormal_ear_morphology3.58687058
4MP0002254_reproductive_system_inflammat2.82732622
5MP0005248_abnormal_Harderian_gland2.79873172
6MP0004885_abnormal_endolymph2.38259860
7MP0002653_abnormal_ependyma_morphology2.35577217
8MP0003195_calcinosis2.28170347
9MP0005551_abnormal_eye_electrophysiolog2.22664184
10MP0000383_abnormal_hair_follicle2.14871026
11MP0004043_abnormal_pH_regulation2.14267468
12MP0003646_muscle_fatigue2.09342544
13MP0000566_synostosis2.06277829
14MP0003011_delayed_dark_adaptation2.05825365
15MP0000427_abnormal_hair_cycle1.97582882
16MP0010030_abnormal_orbit_morphology1.85832263
17MP0000569_abnormal_digit_pigmentation1.85245920
18MP0005083_abnormal_biliary_tract1.81510605
19MP0005253_abnormal_eye_physiology1.76823928
20MP0001968_abnormal_touch/_nociception1.74700434
21MP0002638_abnormal_pupillary_reflex1.73309877
22MP0002837_dystrophic_cardiac_calcinosis1.68551773
23MP0002876_abnormal_thyroid_physiology1.67422006
24MP0003136_yellow_coat_color1.66414380
25MP0001986_abnormal_taste_sensitivity1.65003823
26MP0005503_abnormal_tendon_morphology1.58400988
27MP0006072_abnormal_retinal_apoptosis1.55796977
28MP0001485_abnormal_pinna_reflex1.44664427
29MP0001501_abnormal_sleep_pattern1.43624892
30MP0002909_abnormal_adrenal_gland1.43326680
31MP0010678_abnormal_skin_adnexa1.40881380
32MP0002938_white_spotting1.38287205
33MP0001756_abnormal_urination1.37751909
34MP0008995_early_reproductive_senescence1.36119564
35MP0000026_abnormal_inner_ear1.34557260
36MP0004133_heterotaxia1.31500865
37MP0005167_abnormal_blood-brain_barrier1.31468652
38MP0006276_abnormal_autonomic_nervous1.31169809
39MP0000631_abnormal_neuroendocrine_gland1.29439620
40MP0003938_abnormal_ear_development1.21250848
41MP0004782_abnormal_surfactant_physiolog1.20206579
42MP0006292_abnormal_olfactory_placode1.19768064
43MP0005379_endocrine/exocrine_gland_phen1.15271025
44MP0000230_abnormal_systemic_arterial1.13997276
45MP0003045_fibrosis1.13956998
46MP0004742_abnormal_vestibular_system1.13525307
47MP0001502_abnormal_circadian_rhythm1.12537581
48MP0008872_abnormal_physiological_respon1.10040914
49MP0003724_increased_susceptibility_to1.06988162
50MP0002295_abnormal_pulmonary_circulatio1.06772280
51MP0005646_abnormal_pituitary_gland1.06094906
52MP0003137_abnormal_impulse_conducting1.05639520
53MP0002282_abnormal_trachea_morphology1.05280142
54MP0008775_abnormal_heart_ventricle1.05145202
55MP0001984_abnormal_olfaction1.05081146
56MP0002277_abnormal_respiratory_mucosa1.03468854
57MP0004147_increased_porphyrin_level1.03435984
58MP0002736_abnormal_nociception_after1.01900126
59MP0001919_abnormal_reproductive_system1.01470814
60MP0010368_abnormal_lymphatic_system1.00332231
61MP0008875_abnormal_xenobiotic_pharmacok1.00168048
62MP0001346_abnormal_lacrimal_gland0.97497681
63MP0004215_abnormal_myocardial_fiber0.95651543
64MP0001661_extended_life_span0.95309484
65MP0001879_abnormal_lymphatic_vessel0.94093963
66MP0000613_abnormal_salivary_gland0.93169723
67MP0003787_abnormal_imprinting0.92690602
68MP0001963_abnormal_hearing_physiology0.92283801
69MP0009745_abnormal_behavioral_response0.91860896
70MP0004085_abnormal_heartbeat0.91192964
71MP0002933_joint_inflammation0.90370222
72MP0002168_other_aberrant_phenotype0.89086842
73MP0001486_abnormal_startle_reflex0.88975343
74MP0001177_atelectasis0.87565793
75MP0009384_cardiac_valve_regurgitation0.84293430
76MP0008961_abnormal_basal_metabolism0.84109005
77MP0005171_absent_coat_pigmentation0.83830981
78MP0002557_abnormal_social/conspecific_i0.83809716
79MP0001324_abnormal_eye_pigmentation0.82367188
80MP0002272_abnormal_nervous_system0.81756120
81MP0008877_abnormal_DNA_methylation0.80797925
82MP0005391_vision/eye_phenotype0.80009787
83MP0003119_abnormal_digestive_system0.79199187
84MP0005389_reproductive_system_phenotype0.78928659
85MP0000470_abnormal_stomach_morphology0.78726356
86MP0004484_altered_response_of0.78156386
87MP0001970_abnormal_pain_threshold0.78025601
88MP0002098_abnormal_vibrissa_morphology0.77963308
89MP0005195_abnormal_posterior_eye0.77820417
90MP0000013_abnormal_adipose_tissue0.77136676
91MP0009046_muscle_twitch0.76969977
92MP0003936_abnormal_reproductive_system0.76176338
93MP0003879_abnormal_hair_cell0.75786004
94MP0004142_abnormal_muscle_tone0.74938239
95MP0004019_abnormal_vitamin_homeostasis0.74125899
96MP0004130_abnormal_muscle_cell0.73223634
97MP0005075_abnormal_melanosome_morpholog0.72152456
98MP0002733_abnormal_thermal_nociception0.71776980
99MP0010329_abnormal_lipoprotein_level0.71352417
100MP0001664_abnormal_digestion0.70837352

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.14983589
2Concave nail (HP:0001598)4.05952965
3Congenital stationary night blindness (HP:0007642)3.93663772
4Nephronophthisis (HP:0000090)3.89968418
5True hermaphroditism (HP:0010459)3.80558947
6Molar tooth sign on MRI (HP:0002419)3.74008522
7Abnormality of midbrain morphology (HP:0002418)3.74008522
8Tubular atrophy (HP:0000092)3.67765543
9Abnormality of the renal medulla (HP:0100957)3.65498711
10Pancreatic fibrosis (HP:0100732)3.65440158
11Hyperventilation (HP:0002883)3.59265883
12Chronic hepatic failure (HP:0100626)3.54364397
13Abnormality of the renal cortex (HP:0011035)3.47007899
14Abnormal drinking behavior (HP:0030082)3.10261997
15Polydipsia (HP:0001959)3.10261997
16Cystic liver disease (HP:0006706)3.03075889
17Thyroid-stimulating hormone excess (HP:0002925)2.98584060
18Decreased circulating renin level (HP:0003351)2.96735103
19Keratoconus (HP:0000563)2.95770265
20Increased corneal curvature (HP:0100692)2.95770265
21Attenuation of retinal blood vessels (HP:0007843)2.79343955
22Stage 5 chronic kidney disease (HP:0003774)2.74814772
23Genetic anticipation (HP:0003743)2.70510214
24Progressive cerebellar ataxia (HP:0002073)2.55037829
25Tachypnea (HP:0002789)2.47180734
26Abolished electroretinogram (ERG) (HP:0000550)2.46293048
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40751684
28Type II lissencephaly (HP:0007260)2.39501663
29Clumsiness (HP:0002312)2.39421447
30Polyuria (HP:0000103)2.39166182
31Congenital hepatic fibrosis (HP:0002612)2.38819676
32Flat capital femoral epiphysis (HP:0003370)2.37672772
33Medial flaring of the eyebrow (HP:0010747)2.34706016
34Mesangial abnormality (HP:0001966)2.31456273
35Large for gestational age (HP:0001520)2.23146685
36Gaze-evoked nystagmus (HP:0000640)2.22236748
37Partial duplication of thumb phalanx (HP:0009944)2.18895060
38Decreased central vision (HP:0007663)2.17423283
39Tubulointerstitial fibrosis (HP:0005576)2.15088756
40Abnormal rod and cone electroretinograms (HP:0008323)2.15022548
41Protruding tongue (HP:0010808)2.13350687
42Conical tooth (HP:0000698)2.12132736
43Glomerulonephritis (HP:0000099)2.11807377
44Preaxial foot polydactyly (HP:0001841)2.10194296
45Patellar aplasia (HP:0006443)2.09969773
46Absent speech (HP:0001344)2.09852797
47Tubulointerstitial nephritis (HP:0001970)2.05343286
48Bony spicule pigmentary retinopathy (HP:0007737)2.02414423
49Postaxial foot polydactyly (HP:0001830)2.01818745
50Abnormality of renin-angiotensin system (HP:0000847)2.01258644
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.00757636
52Aplasia/Hypoplasia of the tibia (HP:0005772)1.99536614
53Aplasia/Hypoplasia of the patella (HP:0006498)1.99481268
54Genital tract atresia (HP:0001827)1.95857998
55Partial duplication of the phalanx of hand (HP:0009999)1.95001626
56Broad-based gait (HP:0002136)1.93469648
57Amelogenesis imperfecta (HP:0000705)1.92937390
58Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.92900137
59Occipital encephalocele (HP:0002085)1.92890202
60Abnormality of incisor morphology (HP:0011063)1.92864333
61Vaginal atresia (HP:0000148)1.91636770
62Furrowed tongue (HP:0000221)1.91518516
63Inability to walk (HP:0002540)1.91110106
64Male pseudohermaphroditism (HP:0000037)1.90781688
65Tubulointerstitial abnormality (HP:0001969)1.90559342
66Hypoplastic ischia (HP:0003175)1.90280451
67Short hallux (HP:0010109)1.88842343
68Absent/shortened dynein arms (HP:0200106)1.87433818
69Dynein arm defect of respiratory motile cilia (HP:0012255)1.87433818
70Abnormality of the ischium (HP:0003174)1.87380380
71Macular degeneration (HP:0000608)1.86875990
72Pigmentary retinal degeneration (HP:0001146)1.86465120
73Abnormality of renal excretion (HP:0011036)1.86210329
74Aplasia involving bones of the extremities (HP:0009825)1.85661513
75Aplasia involving bones of the upper limbs (HP:0009823)1.85661513
76Aplasia of the phalanges of the hand (HP:0009802)1.85661513
77Pendular nystagmus (HP:0012043)1.83834399
78Congenital sensorineural hearing impairment (HP:0008527)1.83791395
79Hyperkalemia (HP:0002153)1.83715410
80Nonprogressive disorder (HP:0003680)1.82891986
81Stomach cancer (HP:0012126)1.82279533
82Hypoplasia of the ulna (HP:0003022)1.79114025
83Gait imbalance (HP:0002141)1.78479517
84Aplasia/Hypoplasia of the hallux (HP:0008362)1.78428238
85Nephritis (HP:0000123)1.78402074
86Abnormal urine output (HP:0012590)1.78363899
87Anencephaly (HP:0002323)1.78200357
88Tented upper lip vermilion (HP:0010804)1.77641493
89Congenital primary aphakia (HP:0007707)1.76549837
90Widely spaced teeth (HP:0000687)1.76465457
91Hypoplasia of the fovea (HP:0007750)1.73421589
92Aplasia/Hypoplasia of the fovea (HP:0008060)1.73421589
93Nephrotic syndrome (HP:0000100)1.73331510
94Growth hormone deficiency (HP:0000824)1.71815916
95Optic nerve hypoplasia (HP:0000609)1.71530355
96Hypothermia (HP:0002045)1.70845708
97Alacrima (HP:0000522)1.70693727
98Infantile muscular hypotonia (HP:0008947)1.68969803
99Neonatal respiratory distress (HP:0002643)1.68868688
100Abnormal biliary tract physiology (HP:0012439)1.68806850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.24830625
2ADRBK22.90352541
3WNK32.47965645
4BMPR1B2.32679701
5GRK12.19229108
6EPHA32.10136052
7MAP4K22.06499598
8FGFR22.05497578
9MAPK152.05334638
10INSRR2.02476352
11DAPK22.00606384
12FER1.99222022
13STK38L1.88995123
14TAOK31.77804323
15PINK11.72448698
16ACVR1B1.72367591
17TIE11.58300374
18TNK21.53821258
19WNK41.51103126
20MAPK131.44243190
21NUAK11.40176176
22BLK1.36569993
23PTK2B1.33736974
24LATS11.33147675
25PAK31.32742390
26AKT31.31975392
27TLK11.30714917
28OXSR11.30703635
29IRAK11.30066755
30NLK1.22337362
31CASK1.18994742
32ERBB21.13112073
33MAP3K41.09995518
34MAPKAPK31.09801826
35ADRBK11.08245248
36PRKAA21.04384596
37HIPK21.04290301
38DYRK21.02488357
39PRKCE1.01217591
40CAMK1D0.96474738
41MYLK0.96362425
42SGK20.93419654
43PIK3CG0.90000447
44ZAK0.86474815
45MAP3K70.85067047
46STK30.80690539
47TXK0.80005911
48SGK2230.78171707
49SGK4940.78171707
50GRK50.76680723
51STK110.73521157
52MARK20.72813445
53STK390.72275453
54MAP2K60.69694874
55CHUK0.65250824
56NTRK30.63326247
57PIK3CA0.62909718
58TGFBR10.62086080
59CAMK10.62049407
60NME10.61251697
61RPS6KA60.61058207
62PKN10.58922061
63BRSK20.58457708
64TGFBR20.57661767
65CAMK1G0.57656871
66CDC42BPA0.57158461
67TNIK0.56496811
68MUSK0.55694584
69OBSCN0.55582891
70PRKD10.55533533
71MKNK20.55482298
72PRKCZ0.54276590
73EPHA40.52905051
74PRKACA0.52092121
75MAPK70.51040343
76PRKCG0.51002240
77EPHB20.50973713
78MAP2K70.49468608
79KDR0.49383939
80EPHB10.48580906
81PRKD20.46743016
82MARK10.46726820
83IKBKB0.46505653
84MATK0.45812709
85EPHA20.43829089
86TEC0.43473194
87GRK70.43239302
88PRKAA10.41762083
89CAMK40.41237205
90TRIM280.40792296
91CAMKK20.40529427
92MAP3K60.40047572
93VRK10.39757866
94CSNK1A10.39727140
95RPS6KA50.38194181
96CSNK1G10.36894928
97PRKCI0.36762895
98PRKG10.35595928
99PHKG20.35240371
100PHKG10.35240371

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18462979
2Nitrogen metabolism_Homo sapiens_hsa009103.11299613
3Linoleic acid metabolism_Homo sapiens_hsa005912.77409415
4Phototransduction_Homo sapiens_hsa047442.67040748
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40501130
6Tryptophan metabolism_Homo sapiens_hsa003802.32527245
7ABC transporters_Homo sapiens_hsa020102.13084526
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04680608
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04286113
10Ether lipid metabolism_Homo sapiens_hsa005652.00670282
11Ovarian steroidogenesis_Homo sapiens_hsa049131.94650515
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90845903
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83088698
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71992889
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70440722
16Arachidonic acid metabolism_Homo sapiens_hsa005901.61712575
17Butanoate metabolism_Homo sapiens_hsa006501.58606207
18Taste transduction_Homo sapiens_hsa047421.55233921
19Histidine metabolism_Homo sapiens_hsa003401.48948694
20Morphine addiction_Homo sapiens_hsa050321.35184359
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.31710516
22Olfactory transduction_Homo sapiens_hsa047401.27767208
23Selenocompound metabolism_Homo sapiens_hsa004501.24586716
24Caffeine metabolism_Homo sapiens_hsa002321.24483165
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.21968530
26Circadian rhythm_Homo sapiens_hsa047101.21790145
27beta-Alanine metabolism_Homo sapiens_hsa004101.21501163
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17687576
29Insulin secretion_Homo sapiens_hsa049111.17624089
30Nicotine addiction_Homo sapiens_hsa050331.16788280
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16432416
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15563036
33Circadian entrainment_Homo sapiens_hsa047131.12538507
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.12231267
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10583514
36Dorso-ventral axis formation_Homo sapiens_hsa043201.10138345
37Chemical carcinogenesis_Homo sapiens_hsa052041.08130372
38ECM-receptor interaction_Homo sapiens_hsa045121.07123026
39Salivary secretion_Homo sapiens_hsa049701.05163203
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.03073906
41Propanoate metabolism_Homo sapiens_hsa006401.02891827
42Glutamatergic synapse_Homo sapiens_hsa047241.01341950
43Serotonergic synapse_Homo sapiens_hsa047261.01210284
44Peroxisome_Homo sapiens_hsa041460.96531328
45Basal cell carcinoma_Homo sapiens_hsa052170.95795085
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95454122
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92729539
48Calcium signaling pathway_Homo sapiens_hsa040200.91806643
49Dilated cardiomyopathy_Homo sapiens_hsa054140.90263569
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.85715660
51cAMP signaling pathway_Homo sapiens_hsa040240.85203107
52Hedgehog signaling pathway_Homo sapiens_hsa043400.82740141
53Mineral absorption_Homo sapiens_hsa049780.82666403
54GABAergic synapse_Homo sapiens_hsa047270.81293446
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81284699
56Gastric acid secretion_Homo sapiens_hsa049710.79932516
57Regulation of autophagy_Homo sapiens_hsa041400.79234032
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79068612
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.78837856
60Renin secretion_Homo sapiens_hsa049240.76860291
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75386645
62Lysine degradation_Homo sapiens_hsa003100.74301091
63Fanconi anemia pathway_Homo sapiens_hsa034600.73820219
64Sphingolipid metabolism_Homo sapiens_hsa006000.73168580
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.72471376
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72035636
67Oxidative phosphorylation_Homo sapiens_hsa001900.69928440
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68016507
69Basal transcription factors_Homo sapiens_hsa030220.67172838
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67076665
71Collecting duct acid secretion_Homo sapiens_hsa049660.66048950
72Oxytocin signaling pathway_Homo sapiens_hsa049210.65729314
73Cardiac muscle contraction_Homo sapiens_hsa042600.62006763
74Fatty acid degradation_Homo sapiens_hsa000710.61063128
75Glycerolipid metabolism_Homo sapiens_hsa005610.60718502
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60661046
77Retinol metabolism_Homo sapiens_hsa008300.57515472
78Bile secretion_Homo sapiens_hsa049760.56825826
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56518352
80Axon guidance_Homo sapiens_hsa043600.55093559
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.54068522
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52734908
83Homologous recombination_Homo sapiens_hsa034400.52719859
84Platelet activation_Homo sapiens_hsa046110.52170926
85Ras signaling pathway_Homo sapiens_hsa040140.51933903
86Thyroid hormone synthesis_Homo sapiens_hsa049180.49691436
87Melanoma_Homo sapiens_hsa052180.48236055
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47146629
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46605893
90Pancreatic secretion_Homo sapiens_hsa049720.45883143
91Cholinergic synapse_Homo sapiens_hsa047250.45570523
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.45564773
93Fatty acid biosynthesis_Homo sapiens_hsa000610.43719397
94Cocaine addiction_Homo sapiens_hsa050300.42819687
95Notch signaling pathway_Homo sapiens_hsa043300.42639024
96Hippo signaling pathway_Homo sapiens_hsa043900.42390582
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42271119
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40647894
99Protein digestion and absorption_Homo sapiens_hsa049740.40633674
100Vitamin digestion and absorption_Homo sapiens_hsa049770.37572912

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