CPB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.75272064
2transcytosis (GO:0045056)8.68992689
3cholesterol catabolic process (GO:0006707)7.55397764
4sterol catabolic process (GO:0016127)7.55397764
5cobalamin metabolic process (GO:0009235)7.30535082
6Golgi transport vesicle coating (GO:0048200)7.04749067
7COPI coating of Golgi vesicle (GO:0048205)7.04749067
8phosphatidylinositol acyl-chain remodeling (GO:0036149)6.87397843
9peptidyl-proline hydroxylation (GO:0019511)6.50305304
10phosphatidylserine acyl-chain remodeling (GO:0036150)6.32977861
11phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.28803117
12negative regulation of digestive system process (GO:0060457)6.12661908
13membrane lipid catabolic process (GO:0046466)6.01387278
14glycolipid catabolic process (GO:0019377)5.86754126
15regulation of phospholipase A2 activity (GO:0032429)5.77365660
16ceramide catabolic process (GO:0046514)5.59820792
17activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.48546697
18positive regulation of nuclease activity (GO:0032075)5.23168935
19polyketide metabolic process (GO:0030638)5.20034810
20doxorubicin metabolic process (GO:0044598)5.20034810
21daunorubicin metabolic process (GO:0044597)5.20034810
22protein maturation by protein folding (GO:0022417)5.10426296
23cysteine metabolic process (GO:0006534)5.05535580
24protein hydroxylation (GO:0018126)5.01946178
25fatty acid derivative transport (GO:1901571)4.96891542
26icosanoid transport (GO:0071715)4.96891542
27regulation of keratinocyte differentiation (GO:0045616)4.84394014
28endoplasmic reticulum unfolded protein response (GO:0030968)4.83250366
29endocrine pancreas development (GO:0031018)4.82355913
30aminoglycoside antibiotic metabolic process (GO:0030647)4.75882993
31regulation of nuclease activity (GO:0032069)4.75275601
32tetrapyrrole metabolic process (GO:0033013)4.71655731
33cellular response to unfolded protein (GO:0034620)4.68820259
34phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.66678118
35response to endoplasmic reticulum stress (GO:0034976)4.66636245
36valine metabolic process (GO:0006573)4.66626297
37proline biosynthetic process (GO:0006561)4.61307651
38primary alcohol catabolic process (GO:0034310)4.52337902
39intestinal epithelial cell development (GO:0060576)4.52163849
40COPII vesicle coating (GO:0048208)4.48828162
41ER-nucleus signaling pathway (GO:0006984)4.48116870
42innate immune response in mucosa (GO:0002227)4.45056009
43cellular response to topologically incorrect protein (GO:0035967)4.43590966
44branched-chain amino acid catabolic process (GO:0009083)4.39118967
45regulation of acrosome reaction (GO:0060046)4.38664228
46homocysteine metabolic process (GO:0050667)4.23285103
47zinc ion transport (GO:0006829)4.18057854
48phosphatidylserine metabolic process (GO:0006658)4.17450450
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.16412163
50phospholipid catabolic process (GO:0009395)4.12058609
51cellular modified amino acid catabolic process (GO:0042219)4.06897628
52ER overload response (GO:0006983)4.01770016
53branched-chain amino acid metabolic process (GO:0009081)4.01333119
54signal peptide processing (GO:0006465)3.98686155
554-hydroxyproline metabolic process (GO:0019471)3.98280095
56maintenance of protein localization in organelle (GO:0072595)3.97612448
57regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.96712277
58phosphatidylcholine acyl-chain remodeling (GO:0036151)3.95253555
59ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.82689018
60negative regulation of epidermal cell differentiation (GO:0045605)3.78469265
61response to unfolded protein (GO:0006986)3.76212771
62steroid catabolic process (GO:0006706)3.73874792
63mucosal immune response (GO:0002385)3.70791324
64mitochondrial calcium ion transport (GO:0006851)3.70648480
65glutamine metabolic process (GO:0006541)3.67338423
66water-soluble vitamin metabolic process (GO:0006767)3.65251730
67acute-phase response (GO:0006953)3.63882659
68response to topologically incorrect protein (GO:0035966)3.60529716
69L-alpha-amino acid transmembrane transport (GO:1902475)3.60378226
70protein N-linked glycosylation via asparagine (GO:0018279)3.53723861
71sphingolipid catabolic process (GO:0030149)3.53390993
72peptidyl-asparagine modification (GO:0018196)3.51714404
73alditol phosphate metabolic process (GO:0052646)3.38187360
74phosphatidic acid biosynthetic process (GO:0006654)3.37919182
75phosphatidic acid metabolic process (GO:0046473)3.37919182
76leukotriene biosynthetic process (GO:0019370)3.37335736
77sterol transport (GO:0015918)3.37117222
78cholesterol transport (GO:0030301)3.37117222
79organ or tissue specific immune response (GO:0002251)3.35119262
80positive regulation of heat generation (GO:0031652)3.32633884
81digestive system process (GO:0022600)3.28991125
82vesicle coating (GO:0006901)3.24270436
83positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.22725766
84protein N-linked glycosylation (GO:0006487)3.21202329
85neutrophil mediated immunity (GO:0002446)3.20827661
86coenzyme catabolic process (GO:0009109)3.20181481
87regulation of fever generation (GO:0031620)3.16793636
88aspartate family amino acid catabolic process (GO:0009068)3.15046234
89antibacterial humoral response (GO:0019731)3.11206740
90pancreas development (GO:0031016)3.09786774
91Golgi organization (GO:0007030)3.09187910
92serine family amino acid biosynthetic process (GO:0009070)3.05950647
93creatine metabolic process (GO:0006600)3.04087855
94defense response to Gram-positive bacterium (GO:0050830)3.03531690
95xenobiotic catabolic process (GO:0042178)2.97768118
96negative regulation of epithelial cell differentiation (GO:0030857)2.96489701
97membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93764046
98proline metabolic process (GO:0006560)2.92052763
99cell redox homeostasis (GO:0045454)2.90811726
100regulation of triglyceride catabolic process (GO:0010896)2.90617973
101retinoid metabolic process (GO:0001523)2.89419091
102phototransduction, visible light (GO:0007603)2.88270061
103UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87797106
104antimicrobial humoral response (GO:0019730)2.86367816
105mitochondrion distribution (GO:0048311)2.86086227
106GDP-mannose metabolic process (GO:0019673)2.85995121
107alcohol catabolic process (GO:0046164)2.85689372
108L-phenylalanine catabolic process (GO:0006559)2.85162912
109erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.85162912
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.84751993
111leukotriene metabolic process (GO:0006691)2.81220125
112endothelial cell migration (GO:0043542)2.80816351
113nucleotide-sugar biosynthetic process (GO:0009226)2.80316663
114regulation of epidermal cell differentiation (GO:0045604)2.79784403
115cellular response to cadmium ion (GO:0071276)2.78836647
116vitamin metabolic process (GO:0006766)2.78286922
117water-soluble vitamin biosynthetic process (GO:0042364)2.78078510
118phosphatidylglycerol metabolic process (GO:0046471)2.77149726
119glutathione derivative biosynthetic process (GO:1901687)2.75950331
120glutathione derivative metabolic process (GO:1901685)2.75950331
121diterpenoid metabolic process (GO:0016101)2.75666773
122negative regulation of epidermis development (GO:0045683)2.74348989
123progesterone metabolic process (GO:0042448)2.73734324
124columnar/cuboidal epithelial cell development (GO:0002066)2.73389645
125glandular epithelial cell differentiation (GO:0002067)2.69355788
126acute inflammatory response (GO:0002526)2.68438642
127maintenance of gastrointestinal epithelium (GO:0030277)2.66235309
128negative regulation of hormone metabolic process (GO:0032351)2.61790134
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61360188
130L-phenylalanine metabolic process (GO:0006558)2.61360188
131membrane repolarization during action potential (GO:0086011)2.59801705
132regulation of digestive system process (GO:0044058)2.58465419
133icosanoid secretion (GO:0032309)2.57131206
134arachidonic acid secretion (GO:0050482)2.57131206
135multicellular organismal catabolic process (GO:0044243)2.55193270
136regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.54555599
137phototransduction (GO:0007602)2.53089382
138positive regulation of wound healing (GO:0090303)2.52787231
139phenylpropanoid metabolic process (GO:0009698)2.52341667
140hair cycle (GO:0042633)2.52211417
141molting cycle (GO:0042303)2.52211417
142peptide catabolic process (GO:0043171)2.51697022
143detection of visible light (GO:0009584)2.51420630
144regulation of heat generation (GO:0031650)2.49344318
145cellular response to zinc ion (GO:0071294)2.48983500
146regulation of keratinocyte proliferation (GO:0010837)2.48850822
147ER to Golgi vesicle-mediated transport (GO:0006888)2.48720346
148Leydig cell differentiation (GO:0033327)2.48553859
149myeloid leukocyte mediated immunity (GO:0002444)2.47534872
150cellular protein catabolic process (GO:0044257)2.47329776
151polarized epithelial cell differentiation (GO:0030859)2.46744931
152glycoside metabolic process (GO:0016137)2.42627322
153terpenoid metabolic process (GO:0006721)2.42379427
154retinal metabolic process (GO:0042574)2.42077450
155benzene-containing compound metabolic process (GO:0042537)2.41234614
156multicellular organismal metabolic process (GO:0044236)2.39111031
157cholesterol metabolic process (GO:0008203)2.35469764
158regulation of calcium ion import (GO:0090279)2.33869155
159detection of light stimulus (GO:0009583)2.32833074
160lipid catabolic process (GO:0016042)2.31986051
161intestinal cholesterol absorption (GO:0030299)19.1607219
162exocrine pancreas development (GO:0031017)15.4317580
163digestion (GO:0007586)13.2128473
164protein retention in ER lumen (GO:0006621)11.5952908
165maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.0577048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.76456312
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.41670410
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.84634246
4GATA1_22025678_ChIP-Seq_K562_Human3.83500140
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.39435987
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.78147900
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.76652067
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.69958088
9GATA4_25053715_ChIP-Seq_YYC3_Human2.60358818
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.49729225
11VDR_22108803_ChIP-Seq_LS180_Human2.47337643
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.46815364
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.40000954
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32990666
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.27018112
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25146762
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.16526501
18GATA6_25053715_ChIP-Seq_YYC3_Human2.12081775
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88737182
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83171117
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.81735865
22FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74715285
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72570752
24* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69350868
25PHF8_20622853_ChIP-Seq_HELA_Human1.68975557
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.65665764
27NFYA_21822215_ChIP-Seq_K562_Human1.63820712
28PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.61410957
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.55473814
30CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.55154600
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53222000
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.47602661
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47402577
34PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.46403738
35GATA6_21074721_ChIP-Seq_CACO-2_Human1.45862522
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.44688369
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44570966
38ETV1_20927104_ChIP-Seq_GIST48_Human1.43335423
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42454683
40NFYB_21822215_ChIP-Seq_K562_Human1.42425777
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.41332743
42AHR_22903824_ChIP-Seq_MCF-7_Human1.40372104
43CLOCK_20551151_ChIP-Seq_293T_Human1.40270553
44AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.40078320
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39942116
46TBL1_22424771_ChIP-Seq_293T_Human1.39215065
47SOX2_20726797_ChIP-Seq_SW620_Human1.38696400
48FOXA1_25552417_ChIP-Seq_VCAP_Human1.38423846
49CREB1_26743006_Chip-Seq_LNCaP_Human1.37081678
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.37050382
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34207428
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33697734
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33692048
54JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32570884
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32383306
56CHD1_26751641_Chip-Seq_LNCaP_Human1.31885990
57RBPJ_21746931_ChIP-Seq_IB4_Human1.31486001
58* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30623814
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29283325
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27661805
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25573702
62CBP_20019798_ChIP-Seq_JUKART_Human1.24334731
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24334731
64CBP_21632823_ChIP-Seq_H3396_Human1.24278423
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24115117
66CJUN_26792858_Chip-Seq_BT549_Human1.23831174
67CDX2_22108803_ChIP-Seq_LS180_Human1.23774944
68CBX2_22325352_ChIP-Seq_293T-Rex_Human1.23353432
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23327805
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23327805
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23327805
72TP53_18474530_ChIP-ChIP_U2OS_Human1.22437299
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21878423
74* P300_19829295_ChIP-Seq_ESCs_Human1.21051376
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.20456308
76ZNF274_21170338_ChIP-Seq_K562_Hela1.20137990
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18899016
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.18676956
79EGR1_19032775_ChIP-ChIP_M12_Human1.18192576
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15576524
81AR_20517297_ChIP-Seq_VCAP_Human1.15525483
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14411279
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12841251
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12544585
85SOX2_19829295_ChIP-Seq_ESCs_Human1.12240675
86NANOG_19829295_ChIP-Seq_ESCs_Human1.12240675
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.12231710
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12231710
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11349215
90* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10799018
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10498730
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09235119
93ER_23166858_ChIP-Seq_MCF-7_Human1.09009393
94TBX20_22328084_ChIP-Seq_HEART_Mouse1.08460569
95TBX20_22080862_ChIP-Seq_HEART_Mouse1.08460569
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08019514
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.07987831
98ESET_19884257_ChIP-Seq_ESCs_Mouse1.06628911
99GATA3_24758297_ChIP-Seq_MCF-7_Human1.06148822
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05314406
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05043613
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04694155
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.04489574
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03899195
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02537452
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02533784
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02371874
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02246066
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.01450526
110ERG_20517297_ChIP-Seq_VCAP_Human1.01424845
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01420076
112TP63_22573176_ChIP-Seq_HFKS_Human1.00863227
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00667752
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99092475
115RUNX2_22187159_ChIP-Seq_PCA_Human0.98952118
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.98876169
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98408931
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97714135
119ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97711863
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96195625
121CEBPB_22108803_ChIP-Seq_LS180_Human0.95769291
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95637925
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95465700
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95052307
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.95005009
126KLF4_19829295_ChIP-Seq_ESCs_Human0.94469417
127IRF1_19129219_ChIP-ChIP_H3396_Human0.92122575
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91901443
129* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91889690
130AR_25329375_ChIP-Seq_VCAP_Human0.91623208
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90553817
132* FOXH1_21741376_ChIP-Seq_ESCs_Human0.90499495
133* TAF2_19829295_ChIP-Seq_ESCs_Human0.90254545
134LXR_22292898_ChIP-Seq_THP-1_Human0.90131625
135HOXB7_26014856_ChIP-Seq_BT474_Human0.89924845
136KDM2B_26808549_Chip-Seq_K562_Human0.89754831
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89370688
138P300_27268052_Chip-Seq_Bcells_Human0.88255471
139GBX2_23144817_ChIP-Seq_PC3_Human0.88201952
140GATA1_19941826_ChIP-Seq_K562_Human0.87011814
141ATF3_27146783_Chip-Seq_COLON_Human0.86783800
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.86328800
143HTT_18923047_ChIP-ChIP_STHdh_Human0.85584423
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82895993
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.81968730
146ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81505356
147P68_20966046_ChIP-Seq_HELA_Human0.81383290
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81241517
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80899494
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80602977
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80330678
152CTCF_27219007_Chip-Seq_Bcells_Human0.79368609
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78223755
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77311262
155RACK7_27058665_Chip-Seq_MCF-7_Human0.75934193
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75849576
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75541192
158ERA_21632823_ChIP-Seq_H3396_Human0.74796566
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74277837
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74082415
161HNFA_21074721_ChIP-Seq_CACO-2_Human0.72375738
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.72139839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.55189608
2MP0001666_abnormal_nutrient_absorption8.51884644
3MP0005365_abnormal_bile_salt6.23858475
4MP0005220_abnormal_exocrine_pancreas6.22435420
5MP0003868_abnormal_feces_composition5.13455476
6MP0005084_abnormal_gallbladder_morpholo4.80288843
7MP0002138_abnormal_hepatobiliary_system3.76729840
8MP0002693_abnormal_pancreas_physiology3.17633400
9MP0005085_abnormal_gallbladder_physiolo3.08058545
10MP0003959_abnormal_lean_body2.58772945
11MP0001944_abnormal_pancreas_morphology2.41529718
12MP0003252_abnormal_bile_duct2.36278157
13MP0002928_abnormal_bile_duct2.20316449
14MP0002139_abnormal_hepatobiliary_system2.18221905
15MP0001664_abnormal_digestion2.07750783
16MP0004264_abnormal_extraembryonic_tissu2.02352303
17MP0003705_abnormal_hypodermis_morpholog1.96967381
18MP0008995_early_reproductive_senescence1.91928468
19MP0003300_gastrointestinal_ulcer1.87076542
20MP0003011_delayed_dark_adaptation1.79124328
21MP0010234_abnormal_vibrissa_follicle1.64935492
22MP0005448_abnormal_energy_balance1.63257313
23MP0005646_abnormal_pituitary_gland1.58809239
24MP0003045_fibrosis1.48786420
25MP0003283_abnormal_digestive_organ1.48092801
26MP0009780_abnormal_chondrocyte_physiolo1.35326978
27MP0008872_abnormal_physiological_respon1.30538211
28MP0008004_abnormal_stomach_pH1.29544126
29MP0002078_abnormal_glucose_homeostasis1.28776276
30MP0004233_abnormal_muscle_weight1.27880392
31MP0005165_increased_susceptibility_to1.25229532
32MP0009697_abnormal_copulation1.21067071
33MP0001501_abnormal_sleep_pattern1.20469120
34MP0002118_abnormal_lipid_homeostasis1.19970688
35MP0008875_abnormal_xenobiotic_pharmacok1.16741551
36MP0003638_abnormal_response/metabolism_1.16114346
37MP0009840_abnormal_foam_cell1.10234777
38MP0000003_abnormal_adipose_tissue1.09869289
39MP0002877_abnormal_melanocyte_morpholog1.08520895
40MP0006054_spinal_hemorrhage1.08241747
41MP0008438_abnormal_cutaneous_collagen1.06571475
42MP0002132_abnormal_respiratory_system0.97472302
43MP0000383_abnormal_hair_follicle0.95704014
44MP0008961_abnormal_basal_metabolism0.94258483
45MP0006072_abnormal_retinal_apoptosis0.92258090
46MP0000470_abnormal_stomach_morphology0.88562851
47MP0005410_abnormal_fertilization0.88559795
48MP0003953_abnormal_hormone_level0.86756489
49MP0005332_abnormal_amino_acid0.85375101
50MP0004272_abnormal_basement_membrane0.85352424
51MP0000613_abnormal_salivary_gland0.84430692
52MP0002277_abnormal_respiratory_mucosa0.81722181
53MP0009643_abnormal_urine_homeostasis0.80020592
54MP0000427_abnormal_hair_cycle0.79205138
55MP0010386_abnormal_urinary_bladder0.78692651
56MP0002837_dystrophic_cardiac_calcinosis0.77521015
57MP0005535_abnormal_body_temperature0.77177178
58MP0005408_hypopigmentation0.74808681
59MP0005636_abnormal_mineral_homeostasis0.73063040
60MP0009384_cardiac_valve_regurgitation0.71592955
61MP0002896_abnormal_bone_mineralization0.70272046
62MP0003943_abnormal_hepatobiliary_system0.70045651
63MP0003195_calcinosis0.69684139
64MP0004043_abnormal_pH_regulation0.69239001
65MP0004381_abnormal_hair_follicle0.68393758
66MP0003950_abnormal_plasma_membrane0.68057370
67MP0000647_abnormal_sebaceous_gland0.66882362
68MP0000013_abnormal_adipose_tissue0.65781071
69MP0002163_abnormal_gland_morphology0.65679573
70MP0003183_abnormal_peptide_metabolism0.64174635
71MP0008877_abnormal_DNA_methylation0.64062109
72MP0002909_abnormal_adrenal_gland0.63976609
73MP0003787_abnormal_imprinting0.63299728
74MP0004484_altered_response_of0.62776533
75MP0001502_abnormal_circadian_rhythm0.60066111
76MP0005452_abnormal_adipose_tissue0.59323483
77MP0008789_abnormal_olfactory_epithelium0.56907909
78MP0005058_abnormal_lysosome_morphology0.56418733
79MP0001485_abnormal_pinna_reflex0.56407373
80MP0002970_abnormal_white_adipose0.55116389
81MP0010368_abnormal_lymphatic_system0.54793640
82MP0000598_abnormal_liver_morphology0.54495470
83MP0003879_abnormal_hair_cell0.54398028
84MP0003786_premature_aging0.54263813
85MP0002168_other_aberrant_phenotype0.53406252
86MP0005187_abnormal_penis_morphology0.52867371
87MP0003866_abnormal_defecation0.51926905
88MP0000367_abnormal_coat/_hair0.51911209
89MP0005375_adipose_tissue_phenotype0.51546200
90MP0003878_abnormal_ear_physiology0.50803560
91MP0005377_hearing/vestibular/ear_phenot0.50803560
92MP0004185_abnormal_adipocyte_glucose0.50683744
93MP0005253_abnormal_eye_physiology0.50067060
94MP0002282_abnormal_trachea_morphology0.49035383
95MP0000609_abnormal_liver_physiology0.47270167
96MP0002234_abnormal_pharynx_morphology0.46963418
97MP0006082_CNS_inflammation0.46823392
98MP0005319_abnormal_enzyme/_coenzyme0.46427507
99MP0001731_abnormal_postnatal_growth0.45977674
100MP0000631_abnormal_neuroendocrine_gland0.45947054
101MP0005551_abnormal_eye_electrophysiolog0.45424950
102MP0002822_catalepsy0.45370571
103MP0002060_abnormal_skin_morphology0.44837203
104MP0009703_decreased_birth_body0.44312492
105MP0004019_abnormal_vitamin_homeostasis0.42958828
106MP0002876_abnormal_thyroid_physiology0.42801034
107MP0010329_abnormal_lipoprotein_level0.42562642
108MP0005394_taste/olfaction_phenotype0.41960399
109MP0005499_abnormal_olfactory_system0.41960399
110MP0000490_abnormal_crypts_of0.41379640
111MP0005451_abnormal_body_composition0.40217798
112MP0002009_preneoplasia0.38850390
113MP0001881_abnormal_mammary_gland0.37643562
114MP0003172_abnormal_lysosome_physiology0.36413448
115MP0000371_diluted_coat_color0.36022329
116MP0003795_abnormal_bone_structure0.35623803
117MP0001873_stomach_inflammation0.34311511
118MP0000678_abnormal_parathyroid_gland0.33885385
119MP0002098_abnormal_vibrissa_morphology0.33845204
120MP0002102_abnormal_ear_morphology0.33396229
121MP0005379_endocrine/exocrine_gland_phen0.32994620
122MP0002557_abnormal_social/conspecific_i0.32583216
123MP0005381_digestive/alimentary_phenotyp0.32565514
124MP0005334_abnormal_fat_pad0.32495787
125MP0002160_abnormal_reproductive_system0.32471073
126MP0001663_abnormal_digestive_system0.32367011
127MP0001542_abnormal_bone_strength0.32366058
128MP0001845_abnormal_inflammatory_respons0.32300340
129MP0001765_abnormal_ion_homeostasis0.32093572
130MP0001270_distended_abdomen0.31786652
131MP0009765_abnormal_xenobiotic_induced0.31371171
132MP0000462_abnormal_digestive_system0.30675655
133MP0001756_abnormal_urination0.29674763
134MP0009642_abnormal_blood_homeostasis0.29299171
135MP0010678_abnormal_skin_adnexa0.28950408
136MP0005275_abnormal_skin_tensile0.28480779
137MP0002069_abnormal_eating/drinking_beha0.28226384
138MP0002089_abnormal_postnatal_growth/wei0.28016286
139MP0009672_abnormal_birth_weight0.26425698
140MP0000750_abnormal_muscle_regeneration0.26160371
141MP0001299_abnormal_eye_distance/0.26129053
142MP0003119_abnormal_digestive_system0.23599834
143MP0001661_extended_life_span0.23597114
144MP0000377_abnormal_hair_follicle0.23081953

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.96386182
2Fat malabsorption (HP:0002630)6.90494019
3Gout (HP:0001997)6.35096117
4Exocrine pancreatic insufficiency (HP:0001738)5.50618673
5Abnormal pancreas size (HP:0012094)5.19273966
6Decreased subcutaneous fat (HP:0001002)4.66576298
7Hyperinsulinemic hypoglycemia (HP:0000825)4.59163207
8Abnormality of endocrine pancreas physiology (HP:0012093)4.48168804
9Abnormality of the pancreatic islet cells (HP:0006476)4.48168804
10Hypoglycemic seizures (HP:0002173)4.44974999
11Tetraparesis (HP:0002273)4.33548916
12Abnormality of the intrinsic pathway (HP:0010989)4.31174694
13Hypoglycemic coma (HP:0001325)4.25829478
14Tubulointerstitial fibrosis (HP:0005576)4.20421005
15Ketoacidosis (HP:0001993)4.16006212
16Abnormality of subcutaneous fat tissue (HP:0001001)4.15496842
17Short chin (HP:0000331)4.12376339
18Type I diabetes mellitus (HP:0100651)3.89623547
19Abnormality of the pleura (HP:0002103)3.53879098
20Ketosis (HP:0001946)3.50648902
21Late onset (HP:0003584)3.50335460
22Facial shape deformation (HP:0011334)3.47680135
23Potter facies (HP:0002009)3.47680135
24Hypoplasia of the pons (HP:0012110)3.39886463
25Pancreatitis (HP:0001733)3.38386169
26Maternal diabetes (HP:0009800)3.37954785
27Symptomatic seizures (HP:0011145)3.37196686
28Hyperglycemia (HP:0003074)3.32962671
29Hypoproteinemia (HP:0003075)3.32373297
30Male infertility (HP:0003251)3.26012872
31Tubulointerstitial nephritis (HP:0001970)3.15085054
32Abnormality of aromatic amino acid family metabolism (HP:0004338)3.13921816
33Abnormality of the pons (HP:0007361)3.13778196
34Esophageal varix (HP:0002040)3.06668178
35Premature skin wrinkling (HP:0100678)3.05458661
36Cortical dysplasia (HP:0002539)2.96531311
37Hydroxyprolinuria (HP:0003080)2.93272228
38Abnormality of proline metabolism (HP:0010907)2.93272228
39Insulin-resistant diabetes mellitus (HP:0000831)2.91512438
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.89434580
41Abnormality of the common coagulation pathway (HP:0010990)2.87564579
42Joint stiffness (HP:0001387)2.87376010
43Large for gestational age (HP:0001520)2.86777580
44Pancreatic islet-cell hyperplasia (HP:0004510)2.82235840
45Hyperuricemia (HP:0002149)2.82168657
46Increased purine levels (HP:0004368)2.82168657
47Lip pit (HP:0100267)2.75472679
48Abnormality of the renal cortex (HP:0011035)2.70026091
49Conjugated hyperbilirubinemia (HP:0002908)2.65759087
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63841481
51Congenital, generalized hypertrichosis (HP:0004540)2.63836590
52Unilateral renal agenesis (HP:0000122)2.61990932
53Abnormality of the nasal septum (HP:0000419)2.61689245
54Congenital glaucoma (HP:0001087)2.59901973
55Ileus (HP:0002595)2.59279547
56Carpal bone hypoplasia (HP:0001498)2.58023775
57Ventricular fibrillation (HP:0001663)2.55367388
58Neonatal death (HP:0003811)2.55332262
59Abnormal rod and cone electroretinograms (HP:0008323)2.55228593
60Tubulointerstitial abnormality (HP:0001969)2.50620564
61Dysostosis multiplex (HP:0000943)2.44783403
62Sex reversal (HP:0012245)2.40347857
63Abnormal sex determination (HP:0012244)2.40347857
64Concave nail (HP:0001598)2.36443059
65Dyschromatopsia (HP:0007641)2.35079255
66Long foot (HP:0001833)2.34574942
67Hypoplasia of the odontoid process (HP:0003311)2.27635964
68Abnormal tarsal ossification (HP:0008369)2.26081278
69Severe short stature (HP:0003510)2.25783568
70Macular degeneration (HP:0000608)2.24950597
71Abnormality of purine metabolism (HP:0004352)2.22773403
72Anal atresia (HP:0002023)2.22477321
73Urinary glycosaminoglycan excretion (HP:0003541)2.18428794
74Mucopolysacchariduria (HP:0008155)2.18428794
75Insulin resistance (HP:0000855)2.17989350
76Pigmentary retinal degeneration (HP:0001146)2.17827317
77Pectus carinatum (HP:0000768)2.16391494
78Chorioretinal atrophy (HP:0000533)2.14620373
79Vascular calcification (HP:0004934)2.13101072
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12706502
81Abnormality of sulfur amino acid metabolism (HP:0004339)2.10691034
82Right ventricular cardiomyopathy (HP:0011663)2.09066998
83Sparse lateral eyebrow (HP:0005338)2.08298863
84Acute hepatic failure (HP:0006554)2.06149461
85Type I transferrin isoform profile (HP:0003642)2.06070853
86Hypsarrhythmia (HP:0002521)2.05943628
87Small epiphyses (HP:0010585)2.05273714
88Ankyloglossia (HP:0010296)2.04487244
89Fatigue (HP:0012378)1.99456418
90Abnormality of small intestinal villus morphology (HP:0011472)1.98107462
91Villous atrophy (HP:0011473)1.98107462
92Hyperglycinemia (HP:0002154)1.97502150
93EEG with generalized epileptiform discharges (HP:0011198)1.97081320
94Glucose intolerance (HP:0000833)1.96973488
95Popliteal pterygium (HP:0009756)1.95814027
96Abnormal protein glycosylation (HP:0012346)1.95180077
97Abnormal glycosylation (HP:0012345)1.95180077
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95180077
99Abnormal protein N-linked glycosylation (HP:0012347)1.95180077
100Abnormality of polysaccharide metabolism (HP:0011012)1.94692358
101Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94692358
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94692358
103Prolonged QT interval (HP:0001657)1.94149081
104Enlarged kidneys (HP:0000105)1.93554069
105Distal lower limb muscle weakness (HP:0009053)1.92809270
106Vitreoretinal degeneration (HP:0000655)1.91338769
107Increased CSF protein (HP:0002922)1.90781568
108Abnormal cartilage morphology (HP:0002763)1.90117394
109Limb hypertonia (HP:0002509)1.89530352
110Enlarged penis (HP:0000040)1.89428932
111Cortical visual impairment (HP:0100704)1.89280523
112Rectal prolapse (HP:0002035)1.89252297
113Type II lissencephaly (HP:0007260)1.89109779
114Abolished electroretinogram (ERG) (HP:0000550)1.86970509
115Hypoplasia of the uterus (HP:0000013)1.86420332
116Epileptiform EEG discharges (HP:0011182)1.86324650
117Barrel-shaped chest (HP:0001552)1.86202620
118Autoimmune hemolytic anemia (HP:0001890)1.86170242
119Azoospermia (HP:0000027)1.84512213
120Prenatal maternal abnormality (HP:0002686)1.84280468
121Progressive muscle weakness (HP:0003323)1.82181815
122Thoracolumbar scoliosis (HP:0002944)1.82101892
123Chronic hepatic failure (HP:0100626)1.81629959
124Abnormal foot bone ossification (HP:0010675)1.80558680
125Cardiovascular calcification (HP:0011915)1.78999962
126Abnormality of the odontoid process (HP:0003310)1.77993658
127Myocardial infarction (HP:0001658)1.77264786
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77193996
129Abnormal biliary tract morphology (HP:0012440)1.77015024
130Abnormality of the proximal phalanges of the hand (HP:0009834)1.76865593
131Congenital sensorineural hearing impairment (HP:0008527)1.75982551
132Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74793472
133Pancreatic cysts (HP:0001737)1.74043441
134Tubular atrophy (HP:0000092)1.73739035
135Thick nail (HP:0001805)1.72655466
136Abnormality of macular pigmentation (HP:0008002)1.72127627
137Intrahepatic cholestasis (HP:0001406)1.71158451
138Optic nerve hypoplasia (HP:0000609)1.69894637
139Abdominal distention (HP:0003270)1.69630358
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.64391581
141Cerebellar dysplasia (HP:0007033)1.64029282
142Hyporeflexia of lower limbs (HP:0002600)1.61440211
143Malnutrition (HP:0004395)1.59995652
144Infantile muscular hypotonia (HP:0008947)1.59134459
145Lower limb hyperreflexia (HP:0002395)1.58153962
146Hypothermia (HP:0002045)1.54967665
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.54080415
148Decreased central vision (HP:0007663)1.53262905
149Abnormality of the distal phalanges of the toes (HP:0010182)1.52486632
150Paraparesis (HP:0002385)1.48572533
151Submucous cleft hard palate (HP:0000176)1.47527740
152Flat capital femoral epiphysis (HP:0003370)1.45348218
153Medial flaring of the eyebrow (HP:0010747)1.45302451
154Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.44292587
155Abnormality of methionine metabolism (HP:0010901)1.44215843
156Abnormality of chloride homeostasis (HP:0011422)1.43571962
157Deep philtrum (HP:0002002)1.42191167
158Abnormality of the sella turcica (HP:0002679)1.41109281
159Congenital primary aphakia (HP:0007707)1.39601095
160Depressed nasal tip (HP:0000437)1.37278385
161Autoimmune thrombocytopenia (HP:0001973)1.37007411
162Curly hair (HP:0002212)1.36161121
163Horizontal nystagmus (HP:0000666)1.35423676
164Gait imbalance (HP:0002141)1.35375461
165Reduced antithrombin III activity (HP:0001976)1.34399605
166True hermaphroditism (HP:0010459)1.34218435
167Skin pits (HP:0100276)1.32813531
168Severe visual impairment (HP:0001141)1.32199840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.33988411
2INSRR4.92930505
3ERN14.38670866
4MST44.33700418
5EIF2AK34.15081394
6FRK3.65337695
7MAP2K23.55690410
8AKT33.53240463
9TAOK33.34245539
10TRIB33.00364265
11EPHA22.83633789
12GRK12.38995493
13PKN22.33847198
14PAK32.26225987
15STK242.10055765
16BMPR22.09981787
17MAPK152.04789277
18MAP3K31.98924490
19IRAK31.88008329
20SCYL21.79351387
21ZAP701.73831091
22MAP3K21.70548461
23LATS11.61025887
24MAP3K121.56285242
25MAPKAPK31.51547296
26PTK61.50695570
27WNK41.48789908
28MAP2K11.48090793
29STK161.41713808
30MST1R1.39301277
31MKNK21.37711946
32PASK1.30326277
33PDGFRB1.30021765
34NLK1.24435713
35FLT31.22372207
36PAK21.20707237
37PRKD31.18893518
38BMPR1B1.15720642
39SIK11.15445930
40DYRK1A1.14813582
41MUSK1.14728848
42HIPK21.14181444
43TYRO31.12350587
44CAMKK21.08448436
45PRKCH1.01451117
46MAP3K41.00723065
47BRSK11.00517771
48PDGFRA1.00200902
49WEE10.99044375
50OXSR10.95511401
51ERBB30.94732487
52MAP3K10.93365398
53ADRBK20.93228828
54PRKG20.88035301
55CAMKK10.87430545
56RET0.87057922
57EIF2AK10.86868421
58DYRK1B0.86545496
59IRAK20.85428619
60RIPK10.83883487
61PIK3CG0.81234174
62PIK3CA0.80413763
63MTOR0.77870703
64TBK10.75962190
65FER0.74985376
66TRPM70.74930566
67SGK20.72608253
68EPHA30.71526822
69NTRK10.71525278
70FGFR30.70348576
71FGFR40.69300722
72NME10.68351483
73PTK20.67786974
74CHUK0.67499520
75RPS6KB20.65006591
76FES0.64173660
77EEF2K0.63046953
78IRAK10.60401944
79EPHB10.57688269
80DAPK20.57195148
81MAP3K130.55993402
82MET0.55612065
83MELK0.55279531
84JAK20.54579574
85FGFR20.53619409
86PDPK10.52927538
87SGK30.51102765
88CAMK1D0.50885122
89PRKD10.50351396
90TRIM280.49370641
91RPS6KB10.48495776
92PRKD20.48271634
93IKBKE0.48048505
94STK38L0.47564880
95FGFR10.47409382
96IRAK40.47078188
97NTRK30.45408020
98IKBKB0.44514812
99WNK10.42631190
100BCR0.42059071
101CDC42BPA0.42014405
102KDR0.42006580
103PRKCZ0.41704283
104NEK60.41172975
105PRKCI0.41116795
106KSR20.40428123
107ERBB40.39503749
108LRRK20.39236605
109PIM20.38925887
110PLK20.38872717
111STK390.38682861
112MAP2K60.38621007
113PDK20.38327140
114SGK2230.37977963
115SGK4940.37977963
116CAMK1G0.36786481
117PDK10.36687716
118MYLK0.36682064
119IGF1R0.36291508
120TGFBR20.36267931
121MAP2K70.35866312
122JAK10.34167608
123GSK3A0.33982317
124BRAF0.33939010
125MAP3K70.32876006
126NME20.32381171
127CDK190.31947017
128STK100.30913604
129CSNK1A1L0.30289784
130UHMK10.30246750
131MKNK10.29697572
132BRSK20.29149077
133MAPK30.28760400
134TIE10.28508613
135NUAK10.27611929
136PRKAA10.27007241
137MAP3K50.26180606
138ROCK10.26120160
139ABL10.24422916
140MARK20.24359739
141PRKCQ0.24235384
142DDR20.24127728
143MAP4K20.23643013
144PAK10.23228301
145MAPK10.22936304
146MAPKAPK50.22724155
147EGFR0.20574909
148PRKACB0.20097759
149CSNK1G20.20091564
150PINK10.19959089
151PRKCE0.19374073
152RPS6KA20.18757343
153ADRBK10.18364390
154CASK0.18212973
155ALK0.17179476
156CSNK1A10.16946193
157GRK60.16359678
158AKT10.15999360
159LMTK20.15806843
160CSNK1E0.15672860
161GRK50.15646179
162PRKACA0.15531143

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049727.97440195
2Fat digestion and absorption_Homo sapiens_hsa049756.00388042
3* Protein digestion and absorption_Homo sapiens_hsa049745.13557787
4Maturity onset diabetes of the young_Homo sapiens_hsa049505.11870279
5Protein export_Homo sapiens_hsa030603.45533174
6Glycerolipid metabolism_Homo sapiens_hsa005612.90051599
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.63787211
8Folate biosynthesis_Homo sapiens_hsa007902.33164163
9Vitamin digestion and absorption_Homo sapiens_hsa049771.98593095
10Steroid biosynthesis_Homo sapiens_hsa001001.83972578
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.76656814
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69759951
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68099232
14Renin-angiotensin system_Homo sapiens_hsa046141.57407968
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47067309
16Insulin secretion_Homo sapiens_hsa049111.42635350
17Propanoate metabolism_Homo sapiens_hsa006401.21726301
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08057431
19N-Glycan biosynthesis_Homo sapiens_hsa005101.07154515
20Starch and sucrose metabolism_Homo sapiens_hsa005001.06542143
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02955928
22Sulfur metabolism_Homo sapiens_hsa009201.00218882
23Linoleic acid metabolism_Homo sapiens_hsa005910.97582880
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92156183
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89681007
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88775595
27Selenocompound metabolism_Homo sapiens_hsa004500.88714278
28Histidine metabolism_Homo sapiens_hsa003400.88175104
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81895513
30Vitamin B6 metabolism_Homo sapiens_hsa007500.79338386
31Chemical carcinogenesis_Homo sapiens_hsa052040.77453268
32Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74624250
33Vibrio cholerae infection_Homo sapiens_hsa051100.74034137
34Other glycan degradation_Homo sapiens_hsa005110.73523642
35Influenza A_Homo sapiens_hsa051640.72344470
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69918355
37Arginine and proline metabolism_Homo sapiens_hsa003300.68154933
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.67939514
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66434095
40Type II diabetes mellitus_Homo sapiens_hsa049300.66313679
41Glutathione metabolism_Homo sapiens_hsa004800.65995813
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64527710
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64043568
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62880453
45Notch signaling pathway_Homo sapiens_hsa043300.62832560
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54189256
47Type I diabetes mellitus_Homo sapiens_hsa049400.53603566
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50839018
49Proteasome_Homo sapiens_hsa030500.50749392
50Nitrogen metabolism_Homo sapiens_hsa009100.49903207
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49642485
52Lysosome_Homo sapiens_hsa041420.45436185
53Endometrial cancer_Homo sapiens_hsa052130.45291069
54Insulin resistance_Homo sapiens_hsa049310.42475369
55Biosynthesis of amino acids_Homo sapiens_hsa012300.41550562
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40517976
57Tryptophan metabolism_Homo sapiens_hsa003800.38752067
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38398885
59Retinol metabolism_Homo sapiens_hsa008300.38140804
60One carbon pool by folate_Homo sapiens_hsa006700.38036053
61Tyrosine metabolism_Homo sapiens_hsa003500.37467756
62Fatty acid elongation_Homo sapiens_hsa000620.34999848
63Ovarian steroidogenesis_Homo sapiens_hsa049130.34398592
64Prostate cancer_Homo sapiens_hsa052150.33902261
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33621617
66mTOR signaling pathway_Homo sapiens_hsa041500.33564536
67Cocaine addiction_Homo sapiens_hsa050300.32610746
68Legionellosis_Homo sapiens_hsa051340.32326334
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31928015
70Phototransduction_Homo sapiens_hsa047440.31773087
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.31342927
72Mineral absorption_Homo sapiens_hsa049780.30884835
73Sphingolipid metabolism_Homo sapiens_hsa006000.30716260
74Butanoate metabolism_Homo sapiens_hsa006500.30433996
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28476155
76Fatty acid degradation_Homo sapiens_hsa000710.27708122
77Thyroid hormone synthesis_Homo sapiens_hsa049180.27204136
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27054223
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26814846
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.25384875
81VEGF signaling pathway_Homo sapiens_hsa043700.25279574
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.24785616
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24193027
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23914204
85Estrogen signaling pathway_Homo sapiens_hsa049150.23714207
86beta-Alanine metabolism_Homo sapiens_hsa004100.23441442
87Regulation of autophagy_Homo sapiens_hsa041400.23340628
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22812785
89Oxidative phosphorylation_Homo sapiens_hsa001900.22792662
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22540115
91Tight junction_Homo sapiens_hsa045300.22516803
92Phenylalanine metabolism_Homo sapiens_hsa003600.22419931
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20568583
94Ether lipid metabolism_Homo sapiens_hsa005650.20399818
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20060061
96Toxoplasmosis_Homo sapiens_hsa051450.18832439
97Peroxisome_Homo sapiens_hsa041460.17965541
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16999148
99Arachidonic acid metabolism_Homo sapiens_hsa005900.16753181
100Arginine biosynthesis_Homo sapiens_hsa002200.16451820
101Caffeine metabolism_Homo sapiens_hsa002320.16305456
102Pancreatic cancer_Homo sapiens_hsa052120.16016553
103ABC transporters_Homo sapiens_hsa020100.15866207
104Cholinergic synapse_Homo sapiens_hsa047250.15473361
105Lysine degradation_Homo sapiens_hsa003100.15408342
106Glucagon signaling pathway_Homo sapiens_hsa049220.15250509
107Bladder cancer_Homo sapiens_hsa052190.15247779
108Circadian rhythm_Homo sapiens_hsa047100.14815519
109Calcium signaling pathway_Homo sapiens_hsa040200.14343825
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14107620
111Insulin signaling pathway_Homo sapiens_hsa049100.13658546
112Gastric acid secretion_Homo sapiens_hsa049710.12183796
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.12010646
114Bile secretion_Homo sapiens_hsa049760.11593462
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11138429
116AMPK signaling pathway_Homo sapiens_hsa041520.11105523
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10989000
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.10900044
119Non-small cell lung cancer_Homo sapiens_hsa052230.10787271
120Inositol phosphate metabolism_Homo sapiens_hsa005620.10246007
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10140152
122Complement and coagulation cascades_Homo sapiens_hsa046100.10052889
123Adherens junction_Homo sapiens_hsa045200.09857342
124Metabolic pathways_Homo sapiens_hsa011000.09326918
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09289596
126Prion diseases_Homo sapiens_hsa050200.08783219
127Pyruvate metabolism_Homo sapiens_hsa006200.08562404
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08145311
129Hepatitis C_Homo sapiens_hsa051600.07193573
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.06730474
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06479741
132Viral myocarditis_Homo sapiens_hsa054160.05873545
133Alzheimers disease_Homo sapiens_hsa050100.05736748
134Parkinsons disease_Homo sapiens_hsa050120.05047042
135Sulfur relay system_Homo sapiens_hsa041220.03696875
136RNA polymerase_Homo sapiens_hsa030200.03276267
137Fatty acid metabolism_Homo sapiens_hsa012120.02201870
138Collecting duct acid secretion_Homo sapiens_hsa049660.01831904
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.01613041
140Huntingtons disease_Homo sapiens_hsa05016-0.0579812
141Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0537320
142TNF signaling pathway_Homo sapiens_hsa04668-0.0436300
143Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0397439
144Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0371333
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0312471
146RNA degradation_Homo sapiens_hsa03018-0.0096649
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0064922

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