CPB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.27110606
2epoxygenase P450 pathway (GO:0019373)7.85399811
3omega-hydroxylase P450 pathway (GO:0097267)7.61812745
4L-phenylalanine catabolic process (GO:0006559)7.56579809
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.56579809
6L-phenylalanine metabolic process (GO:0006558)7.23887725
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.23887725
8aromatic amino acid family catabolic process (GO:0009074)6.81419204
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.41894048
10indole-containing compound catabolic process (GO:0042436)6.15793789
11indolalkylamine catabolic process (GO:0046218)6.15793789
12tryptophan catabolic process (GO:0006569)6.15793789
13kynurenine metabolic process (GO:0070189)6.03953032
14bile acid biosynthetic process (GO:0006699)5.95906585
15drug metabolic process (GO:0017144)5.83214433
16glyoxylate metabolic process (GO:0046487)5.81461900
17tryptophan metabolic process (GO:0006568)5.79923031
18urea metabolic process (GO:0019627)5.73251638
19urea cycle (GO:0000050)5.73251638
20high-density lipoprotein particle remodeling (GO:0034375)5.72341631
21oxidative demethylation (GO:0070989)5.67418046
22regulation of protein activation cascade (GO:2000257)5.58432979
23complement activation, alternative pathway (GO:0006957)5.57539639
24alpha-linolenic acid metabolic process (GO:0036109)5.50175489
25protein carboxylation (GO:0018214)5.48265763
26peptidyl-glutamic acid carboxylation (GO:0017187)5.48265763
27* negative regulation of fibrinolysis (GO:0051918)5.36066357
28cysteine metabolic process (GO:0006534)5.33829054
29sulfur amino acid catabolic process (GO:0000098)5.32656073
30* regulation of fibrinolysis (GO:0051917)5.28000611
31nitrogen cycle metabolic process (GO:0071941)5.26474601
32regulation of complement activation (GO:0030449)5.19546000
33phenylpropanoid metabolic process (GO:0009698)5.08424279
34serine family amino acid catabolic process (GO:0009071)5.07775649
35bile acid metabolic process (GO:0008206)5.07351218
36regulation of cholesterol esterification (GO:0010872)5.02514267
37reverse cholesterol transport (GO:0043691)5.02418625
38aromatic amino acid family metabolic process (GO:0009072)4.95190518
39regulation of triglyceride catabolic process (GO:0010896)4.94568034
40ethanol metabolic process (GO:0006067)4.93050619
41protein-lipid complex remodeling (GO:0034368)4.91880387
42macromolecular complex remodeling (GO:0034367)4.91880387
43plasma lipoprotein particle remodeling (GO:0034369)4.91880387
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88208935
45tyrosine metabolic process (GO:0006570)4.79965483
46homocysteine metabolic process (GO:0050667)4.74387774
47phospholipid efflux (GO:0033700)4.72601453
48* negative regulation of hemostasis (GO:1900047)4.71105369
49* negative regulation of blood coagulation (GO:0030195)4.71105369
50triglyceride homeostasis (GO:0070328)4.69232615
51acylglycerol homeostasis (GO:0055090)4.69232615
52regulation of humoral immune response (GO:0002920)4.63554848
53alpha-amino acid catabolic process (GO:1901606)4.61273738
54negative regulation of sterol transport (GO:0032372)4.60026594
55negative regulation of cholesterol transport (GO:0032375)4.60026594
56lysine catabolic process (GO:0006554)4.57535772
57lysine metabolic process (GO:0006553)4.57535772
58amino-acid betaine metabolic process (GO:0006577)4.56239579
59intestinal cholesterol absorption (GO:0030299)4.55481483
60plasma lipoprotein particle clearance (GO:0034381)4.51880080
61S-adenosylmethionine metabolic process (GO:0046500)4.40423116
62glycine metabolic process (GO:0006544)4.39524185
63bile acid and bile salt transport (GO:0015721)4.38599967
64indolalkylamine metabolic process (GO:0006586)4.36347692
65cellular ketone body metabolic process (GO:0046950)4.36301520
66cholesterol efflux (GO:0033344)4.34667726
67coenzyme catabolic process (GO:0009109)4.32760789
68* negative regulation of coagulation (GO:0050819)4.29024505
69imidazole-containing compound metabolic process (GO:0052803)4.27294124
70cellular biogenic amine catabolic process (GO:0042402)4.26634402
71amine catabolic process (GO:0009310)4.26634402
72cellular amino acid catabolic process (GO:0009063)4.23906153
73* negative regulation of wound healing (GO:0061045)4.22003988
74glutamate metabolic process (GO:0006536)4.20913958
75cellular glucuronidation (GO:0052695)4.18626617
76serine family amino acid metabolic process (GO:0009069)4.16773956
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.14038559
78plasma lipoprotein particle assembly (GO:0034377)4.13556452
79benzene-containing compound metabolic process (GO:0042537)4.13185264
80alkaloid metabolic process (GO:0009820)4.11823291
81dicarboxylic acid biosynthetic process (GO:0043650)4.05106304
82arginine metabolic process (GO:0006525)4.04127561
83low-density lipoprotein particle remodeling (GO:0034374)4.03895801
84cellular modified amino acid catabolic process (GO:0042219)4.03615902
85daunorubicin metabolic process (GO:0044597)4.02295058
86polyketide metabolic process (GO:0030638)4.02295058
87doxorubicin metabolic process (GO:0044598)4.02295058
88aldehyde catabolic process (GO:0046185)4.02217066
89blood coagulation, intrinsic pathway (GO:0007597)4.00911361
90fat-soluble vitamin biosynthetic process (GO:0042362)4.00695372
91serine family amino acid biosynthetic process (GO:0009070)3.99779376
92ethanol oxidation (GO:0006069)3.99227534
93hormone catabolic process (GO:0042447)3.96149424
94drug catabolic process (GO:0042737)3.94256584
95disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.92585964
96killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.92585964
97complement activation, classical pathway (GO:0006958)3.89446777
98* regulation of plasminogen activation (GO:0010755)3.89044777
99positive regulation of lipoprotein lipase activity (GO:0051006)3.88441121
100positive regulation of triglyceride lipase activity (GO:0061365)3.88441121
101protein activation cascade (GO:0072376)3.85439962
102flavonoid metabolic process (GO:0009812)3.84873762
103complement activation (GO:0006956)3.84863451
104negative regulation of lipase activity (GO:0060192)3.83062045
105cofactor catabolic process (GO:0051187)3.82640758
106very-low-density lipoprotein particle assembly (GO:0034379)3.82432729
107response to mercury ion (GO:0046689)3.82374618
108positive regulation of lipid catabolic process (GO:0050996)3.81628720
109phospholipid homeostasis (GO:0055091)3.80867944
110* fibrinolysis (GO:0042730)3.80206264
111cholesterol homeostasis (GO:0042632)3.78342357
112cytolysis (GO:0019835)3.78200124
113ketone body metabolic process (GO:1902224)3.77460132
114acute-phase response (GO:0006953)3.75809997
115plasma lipoprotein particle organization (GO:0071827)3.73561066
116* positive regulation of hemostasis (GO:1900048)3.73267986
117* positive regulation of blood coagulation (GO:0030194)3.73267986
118sterol homeostasis (GO:0055092)3.72169888
119negative regulation of complement activation (GO:0045916)3.71519841
120uronic acid metabolic process (GO:0006063)3.71363913
121glucuronate metabolic process (GO:0019585)3.71363913
122protein-lipid complex assembly (GO:0065005)3.71017279
123organic acid catabolic process (GO:0016054)3.70161345
124carboxylic acid catabolic process (GO:0046395)3.70161345
125heme transport (GO:0015886)3.68318426
126regulation of bile acid biosynthetic process (GO:0070857)3.67834312
127negative regulation of protein activation cascade (GO:2000258)3.64884121
128opsonization (GO:0008228)3.63844613
129acetyl-CoA metabolic process (GO:0006084)3.63234945
130aminoglycoside antibiotic metabolic process (GO:0030647)3.57791597
131acute inflammatory response (GO:0002526)3.53833012
132regulation of apoptotic cell clearance (GO:2000425)3.53468322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.39291313
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20434035
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.13509168
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.49388268
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29809229
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16758228
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83800809
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.09094094
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00578393
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07638366
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00882032
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0166961
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97580973
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61457879
15HTT_18923047_ChIP-ChIP_STHdh_Human1.57317730
16CLOCK_20551151_ChIP-Seq_293T_Human1.57036839
17GATA1_22025678_ChIP-Seq_K562_Human1.47006019
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41469884
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27894999
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.24477375
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21466553
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20979405
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18409112
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14021952
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01395764
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99349909
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96402141
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95668995
29SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91802148
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91217042
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89584427
32IRF8_22096565_ChIP-ChIP_GC-B_Human0.87205638
33AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84334285
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81676185
35KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80377174
36GATA4_25053715_ChIP-Seq_YYC3_Human0.80109411
37RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79521293
38SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78929004
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78554928
40TCF4_18268006_ChIP-ChIP_LS174T_Human0.77168094
41NFE2_27457419_Chip-Seq_LIVER_Mouse0.76769901
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76758150
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75145017
44RARA_24833708_ChIP-Seq_LIVER_Mouse0.75035221
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74790364
46SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73794628
47ZNF263_19887448_ChIP-Seq_K562_Human0.73043390
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71713999
49SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70625250
50TP53_18474530_ChIP-ChIP_U2OS_Human0.70274426
51HNFA_21074721_ChIP-Seq_CACO-2_Human0.69715691
52* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69060600
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67794099
54SOX2_21211035_ChIP-Seq_LN229_Human0.67548341
55SOX2_20726797_ChIP-Seq_SW620_Human0.66865249
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.65665289
57NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65291802
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65291802
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65244301
60EZH2_27294783_Chip-Seq_NPCs_Mouse0.65180240
61PIAS1_25552417_ChIP-Seq_VCAP_Human0.63943908
62ESR2_21235772_ChIP-Seq_MCF-7_Human0.63672048
63RARB_24833708_ChIP-Seq_LIVER_Mouse0.63438676
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.62394857
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.61333624
66PCGF2_27294783_Chip-Seq_NPCs_Mouse0.60352039
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60106605
68RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59218585
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58720469
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58171929
71PHF8_20622853_ChIP-Seq_HELA_Human0.58159740
72CEBPB_22108803_ChIP-Seq_LS180_Human0.57592938
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.56403375
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55683868
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.55289058
76RAC3_21632823_ChIP-Seq_H3396_Human0.54873014
77SMAD1_18555785_Chip-Seq_ESCs_Mouse0.54376371
78EGR1_19032775_ChIP-ChIP_M12_Human0.54282243
79FOXA1_25552417_ChIP-Seq_VCAP_Human0.54201233
80AR_20517297_ChIP-Seq_VCAP_Human0.53785464
81NFYA_21822215_ChIP-Seq_K562_Human0.53761473
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53140219
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.52872573
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52737434
85CBX2_22325352_ChIP-Seq_293T-Rex_Human0.51983985
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51603885
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.51603252
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.51540482
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.51151126
90MYC_19915707_ChIP-ChIP_AK7_Human0.50426868
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50285028
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.50093538
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.49799742
94RUNX1_27457419_Chip-Seq_LIVER_Mouse0.49717686
95ESRRB_18555785_Chip-Seq_ESCs_Mouse0.48993532
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.48956149
97POU5F1_16518401_ChIP-PET_MESCs_Mouse0.48412457
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.47817178
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.47750913
100LXR_22292898_ChIP-Seq_THP-1_Human0.47588447
101STAT1_17558387_ChIP-Seq_HELA_Human0.46975180
102SPI1_20517297_ChIP-Seq_HL60_Human0.46938048
103IGF1R_20145208_ChIP-Seq_DFB_Human0.46929016
104P53_21459846_ChIP-Seq_SAOS-2_Human0.46477693
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.46476081
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.45764393
107PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45682839
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45599056
109* CBP_21632823_ChIP-Seq_H3396_Human0.45531180
110TAF15_26573619_Chip-Seq_HEK293_Human0.44190438
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43552928
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42546734
113GATA1_19941826_ChIP-Seq_K562_Human0.42110841
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.40976499
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.40847883
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.40610331
117GATA2_19941826_ChIP-Seq_K562_Human0.39974461
118GATA6_25053715_ChIP-Seq_YYC3_Human0.39813712
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39437473
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.38728842
121* TAF2_19829295_ChIP-Seq_ESCs_Human0.38497218
122BCAT_22108803_ChIP-Seq_LS180_Human0.38490781
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38406387
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38272060
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38020475
126ERG_20517297_ChIP-Seq_VCAP_Human0.36361477
127SPI1_26923725_Chip-Seq_HPCs_Mouse0.36049336
128CDX2_22108803_ChIP-Seq_LS180_Human0.35115991
129NCOR_22424771_ChIP-Seq_293T_Human0.34837037
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34801361
131* MYC_27129775_Chip-Seq_CORNEA_Mouse0.34709029
132LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34452382
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33832796
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.33557294
135IRF1_19129219_ChIP-ChIP_H3396_Human0.33183412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.28830721
2MP0005360_urolithiasis7.54196440
3MP0005085_abnormal_gallbladder_physiolo6.45940109
4MP0005365_abnormal_bile_salt6.22980862
5MP0008875_abnormal_xenobiotic_pharmacok5.07876037
6MP0003806_abnormal_nucleotide_metabolis4.24736182
7MP0003252_abnormal_bile_duct3.90762469
8MP0010329_abnormal_lipoprotein_level3.60826572
9MP0009840_abnormal_foam_cell3.30633942
10MP0005083_abnormal_biliary_tract3.04289623
11MP0003195_calcinosis2.78237054
12MP0005332_abnormal_amino_acid2.73728258
13MP0001666_abnormal_nutrient_absorption2.58868478
14MP0003191_abnormal_cellular_cholesterol2.43632729
15MP0000609_abnormal_liver_physiology2.18413859
16MP0004019_abnormal_vitamin_homeostasis2.12840283
17MP0002118_abnormal_lipid_homeostasis2.10125338
18MP0002138_abnormal_hepatobiliary_system2.01401326
19MP0003868_abnormal_feces_composition1.93571937
20* MP0005319_abnormal_enzyme/_coenzyme1.75766728
21MP0001764_abnormal_homeostasis1.69705277
22MP0009697_abnormal_copulation1.67236142
23MP0005584_abnormal_enzyme/coenzyme_acti1.55969737
24MP0003011_delayed_dark_adaptation1.50955563
25MP0005451_abnormal_body_composition1.39237983
26MP0003656_abnormal_erythrocyte_physiolo1.32022494
27MP0003186_abnormal_redox_activity1.27979816
28MP0009643_abnormal_urine_homeostasis1.23738751
29MP0000598_abnormal_liver_morphology1.19215529
30MP0005647_abnormal_sex_gland1.14202287
31MP0003705_abnormal_hypodermis_morpholog1.13113538
32MP0000604_amyloidosis1.11621060
33MP0009764_decreased_sensitivity_to1.06636396
34MP0002254_reproductive_system_inflammat1.04918957
35MP0001915_intracranial_hemorrhage1.02296289
36* MP0009763_increased_sensitivity_to0.99471538
37MP0010368_abnormal_lymphatic_system0.99406691
38MP0005636_abnormal_mineral_homeostasis0.95835326
39* MP0008469_abnormal_protein_level0.88306373
40MP0005408_hypopigmentation0.88136456
41* MP0009642_abnormal_blood_homeostasis0.87310915
42MP0005670_abnormal_white_adipose0.82418588
43MP0005084_abnormal_gallbladder_morpholo0.81751881
44MP0006036_abnormal_mitochondrial_physio0.81523474
45MP0005376_homeostasis/metabolism_phenot0.80871964
46MP0009765_abnormal_xenobiotic_induced0.78749457
47MP0002078_abnormal_glucose_homeostasis0.78266363
48MP0005220_abnormal_exocrine_pancreas0.76956604
49MP0002876_abnormal_thyroid_physiology0.75044852
50MP0002971_abnormal_brown_adipose0.71439179
51MP0005334_abnormal_fat_pad0.68509735
52MP0009053_abnormal_anal_canal0.67206396
53MP0000566_synostosis0.67036502
54MP0003690_abnormal_glial_cell0.67035851
55MP0001661_extended_life_span0.66899674
56MP0005535_abnormal_body_temperature0.66097326
57MP0004130_abnormal_muscle_cell0.65479524
58MP0002282_abnormal_trachea_morphology0.65418805
59MP0003879_abnormal_hair_cell0.65123700
60MP0005187_abnormal_penis_morphology0.64558817
61MP0005266_abnormal_metabolism0.64019653
62MP0000639_abnormal_adrenal_gland0.63342228
63MP0003329_amyloid_beta_deposits0.61885835
64MP0005058_abnormal_lysosome_morphology0.59172743
65MP0001756_abnormal_urination0.58315105
66MP0005464_abnormal_platelet_physiology0.58151279
67MP0006035_abnormal_mitochondrial_morpho0.54514829
68MP0005448_abnormal_energy_balance0.53799681
69MP0005395_other_phenotype0.52082025
70MP0003718_maternal_effect0.50943135
71MP0002928_abnormal_bile_duct0.46846004
72MP0002837_dystrophic_cardiac_calcinosis0.46236373
73MP0002136_abnormal_kidney_physiology0.44861870
74MP0002089_abnormal_postnatal_growth/wei0.44713120
75MP0003638_abnormal_response/metabolism_0.44576756
76MP0003724_increased_susceptibility_to0.43797177
77MP0003436_decreased_susceptibility_to0.43654837
78MP0008874_decreased_physiological_sensi0.43518693
79MP0002822_catalepsy0.43395229
80MP0002249_abnormal_larynx_morphology0.42937849
81MP0004782_abnormal_surfactant_physiolog0.40785669
82MP0003953_abnormal_hormone_level0.40547915
83MP0000579_abnormal_nail_morphology0.40094470
84MP0003075_altered_response_to0.39833501
85MP0005166_decreased_susceptibility_to0.39134708
86MP0005248_abnormal_Harderian_gland0.38330418
87MP0005666_abnormal_adipose_tissue0.37852295
88MP0004381_abnormal_hair_follicle0.37616848
89* MP0008873_increased_physiological_sensi0.37609146
90MP0009672_abnormal_birth_weight0.36489005
91MP0008872_abnormal_physiological_respon0.36415104
92MP0009384_cardiac_valve_regurgitation0.35467703
93MP0009115_abnormal_fat_cell0.33089202
94MP0004883_abnormal_blood_vessel0.32856245
95MP0002796_impaired_skin_barrier0.32707370
96MP0009785_altered_susceptibility_to0.32450334
97MP0000249_abnormal_blood_vessel0.31741760
98MP0001243_abnormal_dermal_layer0.31347823
99MP0002168_other_aberrant_phenotype0.30877903
100MP0002970_abnormal_white_adipose0.30548828
101MP0001881_abnormal_mammary_gland0.30168469
102MP0000230_abnormal_systemic_arterial0.29792192
103MP0001853_heart_inflammation0.29643358
104MP0006082_CNS_inflammation0.28796068
105MP0004272_abnormal_basement_membrane0.27377850
106MP0005164_abnormal_response_to0.27196004
107MP0003632_abnormal_nervous_system0.26696516
108* MP0001845_abnormal_inflammatory_respons0.26500054
109MP0000920_abnormal_myelination0.26487528
110MP0003959_abnormal_lean_body0.25229982
111MP0002060_abnormal_skin_morphology0.24935918
112MP0002132_abnormal_respiratory_system0.24929607
113MP0000427_abnormal_hair_cycle0.24509370
114MP0003122_maternal_imprinting0.23343602
115MP0001851_eye_inflammation0.23162511
116MP0005197_abnormal_uvea_morphology0.21374619
117MP0002128_abnormal_blood_circulation0.21100518
118MP0003878_abnormal_ear_physiology0.19247987
119MP0005377_hearing/vestibular/ear_phenot0.19247987
120MP0000467_abnormal_esophagus_morphology0.19056810
121MP0003172_abnormal_lysosome_physiology0.17828994
122MP0003633_abnormal_nervous_system0.17413339
123MP0003631_nervous_system_phenotype0.17268756

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.55026597
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.34883222
3Intrahepatic cholestasis (HP:0001406)7.33998904
4Prolonged partial thromboplastin time (HP:0003645)6.73008834
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65678594
6Hypobetalipoproteinemia (HP:0003563)6.43398808
7Xanthomatosis (HP:0000991)6.31515342
8Complement deficiency (HP:0004431)5.64450512
9Hyperlipoproteinemia (HP:0010980)5.52461605
10Joint hemorrhage (HP:0005261)4.92674793
11Hypolipoproteinemia (HP:0010981)4.85778017
12Abnormality of the common coagulation pathway (HP:0010990)4.69562869
13Hyperammonemia (HP:0001987)4.57702120
14Epidermoid cyst (HP:0200040)4.51664932
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.44291800
16Hyperglycinemia (HP:0002154)4.32282412
17Abnormality of methionine metabolism (HP:0010901)4.26449461
18Hypoalphalipoproteinemia (HP:0003233)4.25725121
19Ketosis (HP:0001946)4.20579918
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.20169597
21Fat malabsorption (HP:0002630)4.16020007
22Abnormality of complement system (HP:0005339)4.12142274
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11366824
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10106045
25Hypoglycemic coma (HP:0001325)3.90968673
26Abnormality of the intrinsic pathway (HP:0010989)3.88656610
27Abnormality of pyrimidine metabolism (HP:0004353)3.83330894
28Abnormality of glycine metabolism (HP:0010895)3.81108012
29Abnormality of serine family amino acid metabolism (HP:0010894)3.81108012
30Hyperglycinuria (HP:0003108)3.80525336
31Conjugated hyperbilirubinemia (HP:0002908)3.70568036
32Hypercholesterolemia (HP:0003124)3.62006881
33Hyperbilirubinemia (HP:0002904)3.34945448
34Spontaneous abortion (HP:0005268)3.33632215
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32962301
36Abnormality of fatty-acid metabolism (HP:0004359)3.27430007
37Steatorrhea (HP:0002570)3.13052500
38Hypochromic microcytic anemia (HP:0004840)3.03792641
39Abnormality of serum amino acid levels (HP:0003112)3.03443381
40Abnormality of nucleobase metabolism (HP:0010932)3.02738681
41Hepatocellular carcinoma (HP:0001402)3.01287107
42Delayed CNS myelination (HP:0002188)2.99715573
43Ketoacidosis (HP:0001993)2.98023786
44Myocardial infarction (HP:0001658)2.91125919
45Osteomalacia (HP:0002749)2.86705360
46Systemic lupus erythematosus (HP:0002725)2.82143591
47Skin nodule (HP:0200036)2.78892245
48Metabolic acidosis (HP:0001942)2.71008592
49Purpura (HP:0000979)2.68836761
50Acanthocytosis (HP:0001927)2.66744322
51Abnormality of purine metabolism (HP:0004352)2.62442575
52Lethargy (HP:0001254)2.58410858
53Hypoglycemic seizures (HP:0002173)2.55982555
54Glomerulonephritis (HP:0000099)2.55523102
55Abnormal gallbladder morphology (HP:0012437)2.52192433
56Recurrent gram-negative bacterial infections (HP:0005420)2.51846924
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50978446
58Dicarboxylic aciduria (HP:0003215)2.50978446
59Cholecystitis (HP:0001082)2.50351522
60Abnormal gallbladder physiology (HP:0012438)2.50351522
61Vascular calcification (HP:0004934)2.50183973
62Cholelithiasis (HP:0001081)2.45961519
63Amyloidosis (HP:0011034)2.45638648
64Spastic diplegia (HP:0001264)2.43074827
65Cerebral edema (HP:0002181)2.42286223
66Gingival bleeding (HP:0000225)2.39858544
67Gout (HP:0001997)2.39463003
68Mitral stenosis (HP:0001718)2.37678137
69Irritability (HP:0000737)2.34257226
70Neonatal onset (HP:0003623)2.33027771
71Pulmonary embolism (HP:0002204)2.30433827
72Reduced antithrombin III activity (HP:0001976)2.28001473
73Esophageal varix (HP:0002040)2.24741929
74Cardiovascular calcification (HP:0011915)2.21355516
75Fair hair (HP:0002286)2.20970336
76Arthropathy (HP:0003040)2.19935010
77Menorrhagia (HP:0000132)2.18603968
78Thrombophlebitis (HP:0004418)2.18564146
79Malnutrition (HP:0004395)2.17580497
80Hyperphosphaturia (HP:0003109)2.17577593
81Late onset (HP:0003584)2.15094164
82Pancreatitis (HP:0001733)2.12740953
83Sensorimotor neuropathy (HP:0007141)2.11996206
84Enlarged kidneys (HP:0000105)2.11322024
85Brushfield spots (HP:0001088)2.09480532
86Poikilocytosis (HP:0004447)2.08649207
87Hyperinsulinemic hypoglycemia (HP:0000825)2.08519085
88Bifid scrotum (HP:0000048)2.05284210
89Abnormality of urine glucose concentration (HP:0011016)2.05252085
90Glycosuria (HP:0003076)2.05252085
91Abnormality of the gallbladder (HP:0005264)2.04933023
92Vomiting (HP:0002013)2.02829026
93Abnormality of the Achilles tendon (HP:0005109)2.02386186
94Abnormality of iron homeostasis (HP:0011031)1.99782771
95Generalized aminoaciduria (HP:0002909)1.99749002
96Opisthotonus (HP:0002179)1.97382938
97Abnormality of transition element cation homeostasis (HP:0011030)1.95837208
98Hemorrhage of the eye (HP:0011885)1.95263750
99Rickets (HP:0002748)1.91623079
100Joint swelling (HP:0001386)1.87844132
101Elevated alkaline phosphatase (HP:0003155)1.87769344
102Abnormal cartilage morphology (HP:0002763)1.86166195
103Renal cortical cysts (HP:0000803)1.82407723
104Hyperglycemia (HP:0003074)1.81332706
105Abnormal enzyme/coenzyme activity (HP:0012379)1.80522979
106Elevated hepatic transaminases (HP:0002910)1.80068662
107Nephritis (HP:0000123)1.80053378
108Hypophosphatemic rickets (HP:0004912)1.80036355
109Abnormality of proline metabolism (HP:0010907)1.79114720
110Hydroxyprolinuria (HP:0003080)1.79114720
111Neonatal hypoglycemia (HP:0001998)1.79100026
112Increased mean platelet volume (HP:0011877)1.77853325
113Alkalosis (HP:0001948)1.77262706
114Abnormal urine phosphate concentration (HP:0012599)1.76019817
115Increased serum pyruvate (HP:0003542)1.75294844
116Gangrene (HP:0100758)1.75099335
117Status epilepticus (HP:0002133)1.74874940
118Abnormal tarsal ossification (HP:0008369)1.73288964
119Abnormality of vitamin metabolism (HP:0100508)1.73194335
120Increased serum ferritin (HP:0003281)1.72239084
121Abnormality of alkaline phosphatase activity (HP:0004379)1.71261488
122Epistaxis (HP:0000421)1.65186014
123Abnormal platelet volume (HP:0011876)1.58678918
124Abnormal biliary tract physiology (HP:0012439)1.54324529
125Bile duct proliferation (HP:0001408)1.54324529
126Facial shape deformation (HP:0011334)1.53412837
127Potter facies (HP:0002009)1.53412837
128Abnormal delivery (HP:0001787)1.52261932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.04894887
2FGFR44.58571205
3ERN14.49374522
4SIK14.31952719
5TAOK33.28408743
6ERBB43.25503741
7INSRR2.99653576
8MAP2K42.34939791
9MST1R2.17780774
10PKN22.05727302
11MAPK112.02792151
12LATS11.84796115
13FLT31.82666374
14PIK3CG1.79250573
15TYK21.72335670
16NTRK31.71441967
17TRIB31.70914892
18DAPK21.63218938
19NEK91.54616954
20ABL21.53135427
21MAP3K21.49468839
22PTK61.47995456
23FRK1.43109578
24PRPF4B1.37921821
25FGFR21.30577580
26JAK21.27165141
27KDR1.24898021
28MAP3K121.19939735
29EIF2AK11.15539057
30MAP3K71.15075139
31PRKAA21.14542045
32CDK121.10399543
33PINK11.09146002
34FGFR11.07253746
35ERBB21.07241179
36GRK61.05415813
37TBK11.03428953
38PDGFRA1.02492918
39JAK11.02036698
40MAP2K31.00880799
41AKT31.00826650
42STK38L0.99655874
43NLK0.98101575
44MAPK40.96751434
45CAMKK20.96307672
46MAP3K140.95961371
47BCR0.92212577
48MAP3K30.91036931
49MAP3K100.90219349
50EPHA30.89447728
51PRKCZ0.88988256
52EPHB10.88117951
53MET0.87507664
54KSR20.86674408
55MAPK150.85538532
56MAP3K110.81646406
57PRKACG0.76761511
58PRKG10.76675527
59CDK60.76325227
60CAMK2G0.76144648
61MAPK120.75162169
62MAPKAPK30.74350610
63SCYL20.74048700
64FER0.73667807
65CSNK1D0.71941774
66CAMK1D0.69691623
67BRSK20.69576948
68CSNK1E0.69369634
69TIE10.69245755
70DYRK1B0.69068515
71RIPK10.67726771
72PRKACA0.67580907
73WNK40.66782403
74GSK3A0.66590238
75PRKAA10.66553198
76SGK10.65417830
77CSK0.64659595
78MAP2K60.61559168
79SGK30.61284693
80MYLK0.61006263
81PTK20.56848606
82FGFR30.56749231
83RPS6KA30.56303240
84IKBKE0.55991983
85IRAK30.54238859
86CSF1R0.53164024
87PRKCB0.52889165
88MAP3K60.52707736
89MAPK70.52590935
90TGFBR20.52493064
91MAP3K50.51386634
92TAOK20.50031691
93MAP2K10.49770278
94PRKCQ0.49069675
95SRC0.48959435
96CSNK1G10.48726616
97PDPK10.48675390
98MAP3K130.47986827
99RPS6KB10.46355221
100SGK20.46347306
101PRKACB0.45171822
102IGF1R0.44007497
103RET0.43966924
104ZAP700.43305754
105PKN10.42868647
106CSNK2A10.41511093
107EPHA20.40501770
108GRK10.40405698
109CDK40.39998196
110CSNK2A20.39099623
111PRKCG0.38656992
112EPHA40.38156308
113LATS20.37481724
114PBK0.37366482
115MTOR0.35772952
116EGFR0.35563694
117NEK10.33995990
118SGK4940.33982519
119SGK2230.33982519
120TNK20.32641229
121STK160.30889236
122MAP3K10.30260595
123ICK0.30231183
124CAMK40.29761650
125PDK10.29451712
126MAPK30.28389022
127PIK3CA0.27645589
128STK380.27477848
129CSNK1G20.27228586
130PRKCA0.25457164
131IRAK10.24705203
132PAK30.24315823
133CSNK1G30.23651504
134MAP2K20.22765475
135ABL10.22425824
136STK30.20482987
137BMX0.20061907
138CAMK1G0.18580108

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56318960
2Nitrogen metabolism_Homo sapiens_hsa009103.66341713
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45094495
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31518871
5Arginine biosynthesis_Homo sapiens_hsa002203.10569216
6* Complement and coagulation cascades_Homo sapiens_hsa046102.84877105
7Tryptophan metabolism_Homo sapiens_hsa003802.68621797
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63831988
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61210278
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56226231
11Fatty acid degradation_Homo sapiens_hsa000712.45959454
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35141199
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20005615
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13860754
15Butanoate metabolism_Homo sapiens_hsa006502.11645489
16Peroxisome_Homo sapiens_hsa041462.07002350
17Chemical carcinogenesis_Homo sapiens_hsa052041.95190217
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91928958
19Propanoate metabolism_Homo sapiens_hsa006401.89903186
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.89621213
21Histidine metabolism_Homo sapiens_hsa003401.88382863
22PPAR signaling pathway_Homo sapiens_hsa033201.85613608
23Staphylococcus aureus infection_Homo sapiens_hsa051501.83317308
24Caffeine metabolism_Homo sapiens_hsa002321.77922253
25Fatty acid metabolism_Homo sapiens_hsa012121.77859504
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74987280
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.73609565
28beta-Alanine metabolism_Homo sapiens_hsa004101.68840733
29Retinol metabolism_Homo sapiens_hsa008301.67375015
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62291668
31Selenocompound metabolism_Homo sapiens_hsa004501.59515130
32Phenylalanine metabolism_Homo sapiens_hsa003601.57117669
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55856008
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50698301
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50089882
36Bile secretion_Homo sapiens_hsa049761.46682461
37Tyrosine metabolism_Homo sapiens_hsa003501.43952732
38Sulfur metabolism_Homo sapiens_hsa009201.34646442
39Pyruvate metabolism_Homo sapiens_hsa006201.34392254
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.34038773
41Fatty acid elongation_Homo sapiens_hsa000621.30707456
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27451402
43Steroid biosynthesis_Homo sapiens_hsa001001.22348325
44Folate biosynthesis_Homo sapiens_hsa007901.22268306
45Biosynthesis of amino acids_Homo sapiens_hsa012301.21398363
46Fat digestion and absorption_Homo sapiens_hsa049751.19492306
47ABC transporters_Homo sapiens_hsa020101.18983796
48Carbon metabolism_Homo sapiens_hsa012001.12752332
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.07591630
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05276319
51Vitamin B6 metabolism_Homo sapiens_hsa007501.00939168
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99034820
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.96958482
54Arginine and proline metabolism_Homo sapiens_hsa003300.96258849
55Sulfur relay system_Homo sapiens_hsa041220.94164656
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88170378
57Vitamin digestion and absorption_Homo sapiens_hsa049770.86514582
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80034218
59Lysine degradation_Homo sapiens_hsa003100.79780902
60One carbon pool by folate_Homo sapiens_hsa006700.75786935
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70774820
62Glutathione metabolism_Homo sapiens_hsa004800.69018020
63Glycerolipid metabolism_Homo sapiens_hsa005610.65488346
64Pentose phosphate pathway_Homo sapiens_hsa000300.61199785
65Fatty acid biosynthesis_Homo sapiens_hsa000610.51329831
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47058960
67Metabolic pathways_Homo sapiens_hsa011000.45722595
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43863172
69Prion diseases_Homo sapiens_hsa050200.41747956
70Pertussis_Homo sapiens_hsa051330.32748993
71Galactose metabolism_Homo sapiens_hsa000520.26557594
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26551391
73Fructose and mannose metabolism_Homo sapiens_hsa000510.25384258
74Linoleic acid metabolism_Homo sapiens_hsa005910.23439187
75Insulin resistance_Homo sapiens_hsa049310.22360533
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.20886113
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19441183
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16000223
79Glucagon signaling pathway_Homo sapiens_hsa049220.10071816
80Other glycan degradation_Homo sapiens_hsa005110.08461604
81AMPK signaling pathway_Homo sapiens_hsa041520.01432602
82Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2448557
83Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2364935
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2324399
85Bladder cancer_Homo sapiens_hsa05219-0.2292604
86Amoebiasis_Homo sapiens_hsa05146-0.2284140
87Type II diabetes mellitus_Homo sapiens_hsa04930-0.2241449
88Circadian rhythm_Homo sapiens_hsa04710-0.2088966
89Renin-angiotensin system_Homo sapiens_hsa04614-0.1931569
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1927300
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1882359
92Hepatitis C_Homo sapiens_hsa05160-0.1670612
93Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1654242
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1646622
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1616343
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1503289
97Sphingolipid metabolism_Homo sapiens_hsa00600-0.1431299
98African trypanosomiasis_Homo sapiens_hsa05143-0.1406030
99N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1363894
100Regulation of autophagy_Homo sapiens_hsa04140-0.1351042
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1092608
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1008174
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0997078
104Serotonergic synapse_Homo sapiens_hsa04726-0.0679792
105Mineral absorption_Homo sapiens_hsa04978-0.0588512
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0583339
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0558568
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0525321

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