CPD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.12118444
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.05165961
3positive regulation by organism of defense response of other organism involved in symbiotic interact4.05165961
4modulation by symbiont of host immune response (GO:0052553)4.05165961
5positive regulation by symbiont of host defense response (GO:0052509)4.05165961
6modulation by symbiont of host defense response (GO:0052031)4.05165961
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.05165961
8cell adhesion mediated by integrin (GO:0033627)3.82305664
9negative regulation of protein activation cascade (GO:2000258)3.82164721
10hypotonic response (GO:0006971)3.70889214
11COPI coating of Golgi vesicle (GO:0048205)3.69816394
12Golgi transport vesicle coating (GO:0048200)3.69816394
13negative regulation of complement activation (GO:0045916)3.63799600
14skin morphogenesis (GO:0043589)3.62032663
15COPII vesicle coating (GO:0048208)3.47127083
16positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.40547004
17growth hormone receptor signaling pathway (GO:0060396)3.38884616
18response to lipoprotein particle (GO:0055094)3.37303530
19regulation of complement activation (GO:0030449)3.33409915
20regulation of protein activation cascade (GO:2000257)3.30390558
21regulation of transforming growth factor beta2 production (GO:0032909)3.27226351
22detection of molecule of bacterial origin (GO:0032490)3.25658178
23embryonic process involved in female pregnancy (GO:0060136)3.13108801
24nerve growth factor signaling pathway (GO:0038180)3.08566141
25regulation of membrane protein ectodomain proteolysis (GO:0051043)3.05757942
26negative regulation of humoral immune response (GO:0002921)3.05478550
27apoptotic cell clearance (GO:0043277)3.00598822
28central nervous system myelination (GO:0022010)2.98947762
29axon ensheathment in central nervous system (GO:0032291)2.98947762
30retina vasculature morphogenesis in camera-type eye (GO:0061299)2.93037660
31cellular response to growth hormone stimulus (GO:0071378)2.91904692
32positive regulation of macrophage cytokine production (GO:0060907)2.89455422
33negative regulation of fibrinolysis (GO:0051918)2.85372250
34desmosome organization (GO:0002934)2.85274620
35macroautophagy (GO:0016236)2.84402417
36low-density lipoprotein particle clearance (GO:0034383)2.83634494
37cortical actin cytoskeleton organization (GO:0030866)2.81742440
38substrate-dependent cell migration (GO:0006929)2.78275105
39myelin maintenance (GO:0043217)2.74879669
40macrophage activation involved in immune response (GO:0002281)2.74622907
41cytoskeletal anchoring at plasma membrane (GO:0007016)2.74142890
42stress fiber assembly (GO:0043149)2.72216740
43very-low-density lipoprotein particle assembly (GO:0034379)2.70082158
44basement membrane organization (GO:0071711)2.69781254
45nuclear pore complex assembly (GO:0051292)2.69670004
46vesicle coating (GO:0006901)2.67629184
47positive regulation of p38MAPK cascade (GO:1900745)2.66679769
48semaphorin-plexin signaling pathway (GO:0071526)2.63509312
49cell-substrate junction assembly (GO:0007044)2.61856368
50response to laminar fluid shear stress (GO:0034616)2.61265386
51response to host immune response (GO:0052572)2.60003219
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60003219
53regulation of lipoprotein metabolic process (GO:0050746)2.58835515
54platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58538358
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55021195
56regulation of macrophage cytokine production (GO:0010935)2.52506548
57cellular response to nerve growth factor stimulus (GO:1990090)2.51815312
58response to nerve growth factor (GO:1990089)2.51815312
59cellular response to ethanol (GO:0071361)2.49189075
60insulin-like growth factor receptor signaling pathway (GO:0048009)2.48965491
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.48938250
62complement activation, alternative pathway (GO:0006957)2.48852380
63regulation of apoptotic cell clearance (GO:2000425)2.48673986
64regulation of cholesterol homeostasis (GO:2000188)2.47159483
65creatine metabolic process (GO:0006600)2.46856614
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.46054549
67response to host (GO:0075136)2.46054549
68response to host defenses (GO:0052200)2.46054549
69positive regulation of extracellular matrix organization (GO:1903055)2.44119961
70cortical cytoskeleton organization (GO:0030865)2.44056218
71interleukin-6-mediated signaling pathway (GO:0070102)2.42748989
72surfactant homeostasis (GO:0043129)2.41948326
73positive regulation of receptor recycling (GO:0001921)2.41448628
74negative regulation of fatty acid transport (GO:2000192)2.41333625
75plasma lipoprotein particle assembly (GO:0034377)2.40282596
76adhesion of symbiont to host cell (GO:0044650)2.40175901
77virion attachment to host cell (GO:0019062)2.40175901
78bundle of His cell to Purkinje myocyte communication (GO:0086069)2.39959510
79protein hydroxylation (GO:0018126)2.39637472
80negative regulation of anoikis (GO:2000811)2.38560648
81positive regulation of coagulation (GO:0050820)2.38334810
82regulation of cholesterol storage (GO:0010885)2.38222538
83extracellular matrix assembly (GO:0085029)2.37910051
84regulation of transforming growth factor beta production (GO:0071634)2.37583568
85positive regulation of blood coagulation (GO:0030194)2.37076618
86positive regulation of hemostasis (GO:1900048)2.37076618
87import into cell (GO:0098657)2.36201677
88embryonic retina morphogenesis in camera-type eye (GO:0060059)2.36121729
89regulation of cytokine production involved in inflammatory response (GO:1900015)2.36050175
90positive regulation of natural killer cell differentiation (GO:0032825)2.35644897
91lung lobe morphogenesis (GO:0060463)2.35591740
92long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.33491738
93positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32030001
94regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.30753167
95wound healing, spreading of epidermal cells (GO:0035313)2.29600290
96chondrocyte development (GO:0002063)2.29354828
97peptidyl-tyrosine autophosphorylation (GO:0038083)2.29317079
98axon ensheathment (GO:0008366)2.29191339
99ensheathment of neurons (GO:0007272)2.29191339
100I-kappaB phosphorylation (GO:0007252)2.28872768
101cytoplasmic mRNA processing body assembly (GO:0033962)2.28781227
102lipid translocation (GO:0034204)2.28675051
103phospholipid translocation (GO:0045332)2.28675051
104negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.28039877
105negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.26929684
106epithelial cell-cell adhesion (GO:0090136)2.26659015
107protein retention in ER lumen (GO:0006621)2.26075263
108JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.25712872
109protein-lipid complex assembly (GO:0065005)2.23410549
110epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23353652
111myelination (GO:0042552)2.23153284
112microglial cell activation (GO:0001774)2.22728482
113positive regulation of oligodendrocyte differentiation (GO:0048714)2.22613387
114pathway-restricted SMAD protein phosphorylation (GO:0060389)2.22336376
115negative regulation of neurotransmitter secretion (GO:0046929)2.21603410
116positive regulation of osteoblast proliferation (GO:0033690)2.21317014
117negative regulation of keratinocyte proliferation (GO:0010839)2.20634169
118cellular response to interferon-alpha (GO:0035457)2.20423656
119glomerular visceral epithelial cell development (GO:0072015)2.20282432
120L-amino acid import (GO:0043092)2.19572414
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19009761
122regulation of interferon-beta biosynthetic process (GO:0045357)2.18657613
123cellular copper ion homeostasis (GO:0006878)2.18561820
124regulation of fibrinolysis (GO:0051917)2.18275042
125hemidesmosome assembly (GO:0031581)2.17965438
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.17625259
127UDP-N-acetylglucosamine metabolic process (GO:0006047)2.16741923
128membrane protein ectodomain proteolysis (GO:0006509)2.15366623
129positive regulation of endothelial cell apoptotic process (GO:2000353)2.15296450
130cellular response to vitamin D (GO:0071305)2.13023050
131vascular endothelial growth factor signaling pathway (GO:0038084)2.12920678
132branching involved in salivary gland morphogenesis (GO:0060445)2.12766253
133regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.12427051
134renal filtration (GO:0097205)2.11579859
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.10592061
136axon extension involved in axon guidance (GO:0048846)2.10592061
137positive regulation of cellular response to insulin stimulus (GO:1900078)2.09842283
138establishment of endothelial barrier (GO:0061028)2.09694388
139peptidyl-glutamic acid carboxylation (GO:0017187)2.09530986
140protein carboxylation (GO:0018214)2.09530986
141alpha-linolenic acid metabolic process (GO:0036109)2.09256861
142positive regulation of hormone biosynthetic process (GO:0046886)2.09136508
143long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.09125842
144iron ion import (GO:0097286)2.09037294
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.08325375
146gap junction assembly (GO:0016264)2.07039794
147Rap protein signal transduction (GO:0032486)2.06486856
148bone remodeling (GO:0046849)2.06466597
149regulation of interleukin-8 biosynthetic process (GO:0045414)2.06287247
150nuclear pore organization (GO:0006999)2.05971314
151neutrophil activation involved in immune response (GO:0002283)2.04920005
152sequestering of extracellular ligand from receptor (GO:0035581)2.04093752
153positive regulation of insulin receptor signaling pathway (GO:0046628)2.03862537
154regulation of p38MAPK cascade (GO:1900744)2.03823774
155positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.03625129
156regulation of transforming growth factor beta1 production (GO:0032908)2.03365576
157adhesion of symbiont to host (GO:0044406)2.02998366
158wound healing, spreading of cells (GO:0044319)2.02902097
159positive regulation of toll-like receptor signaling pathway (GO:0034123)2.02752397
160asymmetric protein localization (GO:0008105)2.02693636
161positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.01708612
162fatty-acyl-CoA biosynthetic process (GO:0046949)2.01474958
163positive regulation of bone remodeling (GO:0046852)2.00703661
164positive regulation of bone resorption (GO:0045780)2.00703661
165endodermal cell differentiation (GO:0035987)2.00653605
166regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.00459974
167clathrin coat assembly (GO:0048268)2.00112058
168positive regulation of histone deacetylation (GO:0031065)1.99996502
169retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.99706113
170membrane raft organization (GO:0031579)1.98526444
171glomerular epithelial cell development (GO:0072310)1.98072679
172regulation of hormone biosynthetic process (GO:0046885)1.97335829
173negative regulation of protein localization to plasma membrane (GO:1903077)1.96665771
174Golgi organization (GO:0007030)1.96039352
175endocardial cushion development (GO:0003197)1.95831958
176response to methylmercury (GO:0051597)1.94019342
177mesodermal cell differentiation (GO:0048333)1.93420319
178positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610811.92868288
179sodium ion export (GO:0071436)1.92855399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.19070652
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.06744142
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73618628
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.48051225
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24041983
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20469916
7EGR1_19374776_ChIP-ChIP_THP-1_Human1.99167864
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.95444892
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90216198
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.88105874
11FOXO3_23340844_ChIP-Seq_DLD1_Human1.86322448
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85818702
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84268716
14LXR_22158963_ChIP-Seq_LIVER_Mouse1.83528171
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.80251667
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78482083
17CLOCK_20551151_ChIP-Seq_293T_Human1.77962610
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77076898
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74624370
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69640007
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.69011819
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.67939110
23TP53_16413492_ChIP-PET_HCT116_Human1.62957038
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62573968
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.59743287
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58548703
27AR_21909140_ChIP-Seq_LNCAP_Human1.55949109
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55779738
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55779738
30BRD4_25478319_ChIP-Seq_HGPS_Human1.55644907
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.55554375
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54981827
33* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52901562
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.52474789
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51604019
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.50870055
37* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50350990
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.50137474
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49754672
40CJUN_26792858_Chip-Seq_BT549_Human1.47079441
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46182137
42* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45336434
43* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42016527
44AHR_22903824_ChIP-Seq_MCF-7_Human1.40325875
45* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37669903
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.37372617
47* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37015919
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36949518
49SOX2_20726797_ChIP-Seq_SW620_Human1.35247750
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33068167
51VDR_24787735_ChIP-Seq_THP-1_Human1.29271730
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28653618
53* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28525645
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24916114
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23817696
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23745414
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23703486
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23407489
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.23388818
60* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23101495
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22190850
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21834046
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.21611931
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21416981
65* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20934070
66GATA4_25053715_ChIP-Seq_YYC3_Human1.20589678
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20229312
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19716971
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19590700
70* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19040490
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.18497925
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18340167
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.17921684
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17461511
75AR_21572438_ChIP-Seq_LNCaP_Human1.17134394
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15755895
77* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15215622
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14827313
79GATA1_19941826_ChIP-Seq_K562_Human1.14800896
80P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14711978
81RXR_22108803_ChIP-Seq_LS180_Human1.13829337
82* FOXA2_19822575_ChIP-Seq_HepG2_Human1.13562505
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13450006
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13294469
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13294469
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13145338
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12964326
88* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11215614
89* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10733799
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10538970
91* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10259954
92DROSHA_22980978_ChIP-Seq_HELA_Human1.09647654
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09214180
94GATA1_22025678_ChIP-Seq_K562_Human1.08741128
95* GATA6_25053715_ChIP-Seq_YYC3_Human1.08458555
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.08314184
97* TP63_23658742_ChIP-Seq_EP156T_Human1.07407702
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06659130
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06120067
100KLF5_25053715_ChIP-Seq_YYC3_Human1.05955518
101TP53_18474530_ChIP-ChIP_U2OS_Human1.04554718
102KDM2B_26808549_Chip-Seq_K562_Human1.03358748
103* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03131895
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03021667
105* TBX20_22080862_ChIP-Seq_HEART_Mouse1.02926392
106* TBX20_22328084_ChIP-Seq_HEART_Mouse1.02926392
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02561989
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01033651
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00867716
110* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00307615
111TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00265979
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99389808
113* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99293050
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99142504
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.97889104
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97733628
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96520571
118* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95701795
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95082618
120EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94852141
121RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94852141
122* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94782684
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94143104
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94102618
125ZNF263_19887448_ChIP-Seq_K562_Human0.93937599
126* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93208386
127* FOXA1_25552417_ChIP-Seq_VCAP_Human0.92958108
128* RUNX_20019798_ChIP-Seq_JUKART_Human0.92938309
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92930063
130GATA2_19941826_ChIP-Seq_K562_Human0.91892004
131* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91525987
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91217093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.96001575
2MP0008438_abnormal_cutaneous_collagen3.55881548
3MP0003705_abnormal_hypodermis_morpholog2.87517438
4MP0003303_peritoneal_inflammation2.83409403
5MP0005167_abnormal_blood-brain_barrier2.67448479
6MP0004272_abnormal_basement_membrane2.56416000
7MP0005058_abnormal_lysosome_morphology2.34101309
8MP0000920_abnormal_myelination2.33564552
9MP0003950_abnormal_plasma_membrane2.31700726
10MP0003690_abnormal_glial_cell2.20427571
11MP0000604_amyloidosis2.16067900
12MP0009780_abnormal_chondrocyte_physiolo2.13104615
13MP0010234_abnormal_vibrissa_follicle2.09021959
14MP0010678_abnormal_skin_adnexa2.03962889
15MP0001958_emphysema2.02344186
16MP0005623_abnormal_meninges_morphology2.00728571
17MP0005409_darkened_coat_color1.97411027
18MP0005451_abnormal_body_composition1.93497616
19MP0003045_fibrosis1.93038392
20MP0004264_abnormal_extraembryonic_tissu1.91348437
21MP0003566_abnormal_cell_adhesion1.90885898
22MP0003091_abnormal_cell_migration1.87560992
23MP0005275_abnormal_skin_tensile1.86169519
24MP0010352_gastrointestinal_tract_polyps1.84606111
25MP0004858_abnormal_nervous_system1.77628440
26MP0003329_amyloid_beta_deposits1.66187156
27MP0003075_altered_response_to1.62825002
28MP0003172_abnormal_lysosome_physiology1.58376402
29MP0001533_abnormal_skeleton_physiology1.54438681
30MP0005076_abnormal_cell_differentiation1.52685171
31MP0004185_abnormal_adipocyte_glucose1.51713243
32MP0000383_abnormal_hair_follicle1.46479935
33MP0003436_decreased_susceptibility_to1.45355684
34MP0003941_abnormal_skin_development1.44118143
35MP0002009_preneoplasia1.42342736
36MP0005171_absent_coat_pigmentation1.41034574
37MP0003453_abnormal_keratinocyte_physiol1.38998137
38MP0003634_abnormal_glial_cell1.38777476
39MP0000733_abnormal_muscle_development1.38611686
40MP0004130_abnormal_muscle_cell1.38561697
41MP0008260_abnormal_autophagy1.37304173
42MP0003828_pulmonary_edema1.34796311
43MP0001299_abnormal_eye_distance/1.33088528
44MP0009278_abnormal_bone_marrow1.33015743
45MP0002254_reproductive_system_inflammat1.31055180
46MP0000858_altered_metastatic_potential1.30760198
47MP0000003_abnormal_adipose_tissue1.28810897
48MP0002933_joint_inflammation1.26795130
49MP0003279_aneurysm1.25391783
50MP0005257_abnormal_intraocular_pressure1.24370494
51MP0004883_abnormal_blood_vessel1.23851195
52MP0001879_abnormal_lymphatic_vessel1.22493232
53MP0003448_altered_tumor_morphology1.21488205
54MP0002998_abnormal_bone_remodeling1.21379746
55MP0002896_abnormal_bone_mineralization1.19924645
56MP0006054_spinal_hemorrhage1.19063175
57MP0003656_abnormal_erythrocyte_physiolo1.15850063
58MP0003191_abnormal_cellular_cholesterol1.15709940
59MP0003868_abnormal_feces_composition1.15313742
60MP0005164_abnormal_response_to1.14780245
61MP0003252_abnormal_bile_duct1.13957367
62MP0002295_abnormal_pulmonary_circulatio1.13395964
63MP0004084_abnormal_cardiac_muscle1.12352098
64MP0001851_eye_inflammation1.11283032
65MP0002006_tumorigenesis1.10867069
66MP0005388_respiratory_system_phenotype1.10838544
67MP0002133_abnormal_respiratory_system1.10838544
68MP0005165_increased_susceptibility_to1.10828622
69MP0010368_abnormal_lymphatic_system1.10035413
70MP0004510_myositis1.07700474
71MP0005375_adipose_tissue_phenotype1.06840568
72MP0005023_abnormal_wound_healing1.06743093
73MP0004233_abnormal_muscle_weight1.05363082
74MP0006082_CNS_inflammation1.05140753
75MP0004947_skin_inflammation1.03742645
76MP0000767_abnormal_smooth_muscle1.03046837
77MP0000013_abnormal_adipose_tissue1.00738761
78MP0003183_abnormal_peptide_metabolism0.99450760
79MP0003724_increased_susceptibility_to0.99218586
80MP0005085_abnormal_gallbladder_physiolo0.98921641
81MP0003633_abnormal_nervous_system0.98289317
82MP0002419_abnormal_innate_immunity0.97636262
83MP0005166_decreased_susceptibility_to0.96849229
84MP0002877_abnormal_melanocyte_morpholog0.96467144
85MP0001849_ear_inflammation0.96225042
86MP0002139_abnormal_hepatobiliary_system0.93787567
87MP0002086_abnormal_extraembryonic_tissu0.92816562
88MP0005408_hypopigmentation0.91726365
89MP0004782_abnormal_surfactant_physiolog0.90273577
90MP0000537_abnormal_urethra_morphology0.90178319
91MP0001881_abnormal_mammary_gland0.89408323
92MP0000747_muscle_weakness0.86898365
93MP0000569_abnormal_digit_pigmentation0.86774980
94MP0005248_abnormal_Harderian_gland0.86403425
95MP0009840_abnormal_foam_cell0.86225729
96MP0000751_myopathy0.85997571
97MP0000627_abnormal_mammary_gland0.85072150
98MP0001666_abnormal_nutrient_absorption0.84757095
99MP0005621_abnormal_cell_physiology0.84560428
100MP0004036_abnormal_muscle_relaxation0.84319490
101MP0003115_abnormal_respiratory_system0.84310161
102MP0010155_abnormal_intestine_physiology0.83801501
103MP0001177_atelectasis0.82854646
104MP0005365_abnormal_bile_salt0.82826809
105MP0005666_abnormal_adipose_tissue0.81956885
106MP0000343_altered_response_to0.81631038
107MP0009384_cardiac_valve_regurgitation0.81557875
108MP0001216_abnormal_epidermal_layer0.80960420
109MP0009053_abnormal_anal_canal0.80667702
110MP0005390_skeleton_phenotype0.80357902
111MP0008057_abnormal_DNA_replication0.79892660
112MP0001661_extended_life_span0.79882058
113MP0003632_abnormal_nervous_system0.79845394
114MP0005387_immune_system_phenotype0.78964582
115MP0001790_abnormal_immune_system0.78964582
116MP0003195_calcinosis0.77964730
117MP0003631_nervous_system_phenotype0.76343353
118MP0001614_abnormal_blood_vessel0.76323914
119MP0002168_other_aberrant_phenotype0.75680556
120MP0004043_abnormal_pH_regulation0.73630978
121MP0005464_abnormal_platelet_physiology0.73518266
122MP0004087_abnormal_muscle_fiber0.73386384
123MP0000750_abnormal_muscle_regeneration0.73281242
124MP0009785_altered_susceptibility_to0.71976464
125MP0008775_abnormal_heart_ventricle0.71334875
126MP0002090_abnormal_vision0.70188315
127MP0010630_abnormal_cardiac_muscle0.69726929
128MP0000249_abnormal_blood_vessel0.69548994
129MP0002166_altered_tumor_susceptibility0.69238466
130MP0002925_abnormal_cardiovascular_devel0.69203362
131MP0001915_intracranial_hemorrhage0.68513358
132MP0002060_abnormal_skin_morphology0.68297086
133MP0008004_abnormal_stomach_pH0.67745018
134MP0000428_abnormal_craniofacial_morphol0.66967697
135MP0001175_abnormal_lung_morphology0.66502972
136MP0003943_abnormal_hepatobiliary_system0.66020489
137MP0002796_impaired_skin_barrier0.64804032

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)3.69753586
2Cerebral inclusion bodies (HP:0100314)3.68172758
3Insidious onset (HP:0003587)3.65114799
4Termporal pattern (HP:0011008)3.65114799
5Deep venous thrombosis (HP:0002625)3.25350065
6Flat acetabular roof (HP:0003180)3.15410606
7Premature rupture of membranes (HP:0001788)3.14290310
8Abnormality of the common coagulation pathway (HP:0010990)3.09305697
9Mitral stenosis (HP:0001718)3.08578842
10Osteolytic defects of the hand bones (HP:0009699)3.07451077
11Osteolytic defects of the phalanges of the hand (HP:0009771)3.07451077
12Increased cerebral lipofuscin (HP:0011813)3.03938642
13Cerebral aneurysm (HP:0004944)3.01692310
14Hematochezia (HP:0002573)2.93204788
15Arterial tortuosity (HP:0005116)2.84226346
16Shallow orbits (HP:0000586)2.76526755
17Hyporeflexia of lower limbs (HP:0002600)2.63856961
18Vascular tortuosity (HP:0004948)2.59896589
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57286811
20Aortic dissection (HP:0002647)2.56470677
21Hypoplasia of the iris (HP:0007676)2.52455192
22Buphthalmos (HP:0000557)2.50559567
23Axonal loss (HP:0003447)2.49956088
24Difficulty running (HP:0009046)2.49557810
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.49455616
26Persistence of primary teeth (HP:0006335)2.47917859
27Cardiovascular calcification (HP:0011915)2.47101543
28Degeneration of the lateral corticospinal tracts (HP:0002314)2.46064491
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46064491
30Aortic aneurysm (HP:0004942)2.43868801
31Papillary thyroid carcinoma (HP:0002895)2.43406313
32Eczematoid dermatitis (HP:0000976)2.43067843
33Vertebral compression fractures (HP:0002953)2.41540937
34Myocardial infarction (HP:0001658)2.40962400
35Macroorchidism (HP:0000053)2.40091635
36Supranuclear gaze palsy (HP:0000605)2.37945642
37Conjugated hyperbilirubinemia (HP:0002908)2.36163743
38Disinhibition (HP:0000734)2.33061846
39Mitral valve prolapse (HP:0001634)2.32020832
40Atrophic scars (HP:0001075)2.29918475
41Short nail (HP:0001799)2.29849649
42Broad metatarsal (HP:0001783)2.27498979
43Vascular calcification (HP:0004934)2.27193420
44Peritonitis (HP:0002586)2.26901905
45Periodontitis (HP:0000704)2.25341237
46Segmental peripheral demyelination/remyelination (HP:0003481)2.23743376
47Focal segmental glomerulosclerosis (HP:0000097)2.23364024
48Scapular winging (HP:0003691)2.22888196
49Dysostosis multiplex (HP:0000943)2.22732028
50Esophageal varix (HP:0002040)2.20721754
51Ankyloglossia (HP:0010296)2.18456433
52Asymmetry of the thorax (HP:0001555)2.18111283
53Amyloidosis (HP:0011034)2.15663994
54Complement deficiency (HP:0004431)2.15037158
55Onion bulb formation (HP:0003383)2.13911503
56Spondylolisthesis (HP:0003302)2.12291153
57Disproportionate tall stature (HP:0001519)2.12269025
58Abnormality of complement system (HP:0005339)2.11394317
59Abnormality of carpal bone ossification (HP:0006257)2.11125316
60Apathy (HP:0000741)2.08996735
61Coarse hair (HP:0002208)2.08659662
62Abnormality of the acetabulum (HP:0003170)2.08648647
63Abnormality of macrophages (HP:0004311)2.06941695
64Vertebral arch anomaly (HP:0008438)2.06168532
65Thick nail (HP:0001805)2.04453309
66Abnormality of the distal phalanges of the toes (HP:0010182)2.03370667
67Ulnar bowing (HP:0003031)2.02570286
68Increased CSF protein (HP:0002922)2.01437146
69Abnormal foot bone ossification (HP:0010675)1.97524555
70Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94609649
71Neuronal loss in central nervous system (HP:0002529)1.94066575
72Gingival bleeding (HP:0000225)1.93718073
73Protrusio acetabuli (HP:0003179)1.93176879
74Turricephaly (HP:0000262)1.93015878
75Spinal cord lesions (HP:0100561)1.92408907
76Syringomyelia (HP:0003396)1.92408907
77Abnormal ossification of hand bones (HP:0005921)1.92318970
78Subacute progressive viral hepatitis (HP:0006572)1.90800265
79Abnormality of oral frenula (HP:0000190)1.90331878
80Dilatation of the ascending aorta (HP:0005111)1.90084801
81Urinary glycosaminoglycan excretion (HP:0003541)1.90037216
82Mucopolysacchariduria (HP:0008155)1.90037216
83Aneurysm (HP:0002617)1.89436538
84Menorrhagia (HP:0000132)1.89368113
85Broad face (HP:0000283)1.88723535
86Peripheral demyelination (HP:0011096)1.88562856
87Fatigue (HP:0012378)1.88505414
88Blue sclerae (HP:0000592)1.88110761
89Tetraparesis (HP:0002273)1.86551362
90Interstitial pulmonary disease (HP:0006530)1.84560201
91Ankle contracture (HP:0006466)1.83731727
92Thin bony cortex (HP:0002753)1.83530535
93Diminished motivation (HP:0000745)1.83262678
94Action tremor (HP:0002345)1.82358168
95Right ventricular cardiomyopathy (HP:0011663)1.80777701
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.80272182
97Striae distensae (HP:0001065)1.79340499
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78400772
99Abnormality of the corticospinal tract (HP:0002492)1.78121270
100Muscle fiber splitting (HP:0003555)1.77759232
101Fragile skin (HP:0001030)1.77698248
102Advanced eruption of teeth (HP:0006288)1.77243005
103Achilles tendon contracture (HP:0001771)1.76269206
104Increased variability in muscle fiber diameter (HP:0003557)1.73873369
105Glomerulosclerosis (HP:0000096)1.73669314
106Hypobetalipoproteinemia (HP:0003563)1.73436662
107Vacuolated lymphocytes (HP:0001922)1.73292614
108Glomerulonephritis (HP:0000099)1.73093174
109Skin nodule (HP:0200036)1.72487013
110Frequent falls (HP:0002359)1.71661260
111Wormian bones (HP:0002645)1.69780661
112Coxa vara (HP:0002812)1.69758453
113Thickened calvaria (HP:0002684)1.69556595
114Hammertoe (HP:0001765)1.69194844
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68966586
116Abnormality of polysaccharide metabolism (HP:0011012)1.68966586
117Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68966586
118Cervical subluxation (HP:0003308)1.67616028
119Abnormal hand bone ossification (HP:0010660)1.66473743
120Hyperextensible skin (HP:0000974)1.66424142
121Thoracolumbar scoliosis (HP:0002944)1.66067908
122Joint laxity (HP:0001388)1.66014186
123Camptodactyly of toe (HP:0001836)1.65546739
124Recurrent gram-negative bacterial infections (HP:0005420)1.65168124
125Absent frontal sinuses (HP:0002688)1.64312830
126Abnormal vertebral ossification (HP:0100569)1.63204597
127Increased connective tissue (HP:0009025)1.62978159
128Abnormality of the nasal septum (HP:0000419)1.62580104
129Abnormality of the lumbar spine (HP:0100712)1.62534068
130Soft skin (HP:0000977)1.62488566
131Abnormality of monocarboxylic acid metabolism (HP:0010996)1.62285924
132Curly hair (HP:0002212)1.62239788
133Scanning speech (HP:0002168)1.62043442
134Cerebral hemorrhage (HP:0001342)1.62042322
135Hypoplastic ischia (HP:0003175)1.61916548
136Bronchomalacia (HP:0002780)1.61244749
137Wide nose (HP:0000445)1.59784959
138Rapidly progressive (HP:0003678)1.59507833
139Vertebral hypoplasia (HP:0008417)1.58857648
140Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58857648
141Dislocated radial head (HP:0003083)1.58689458
142Hepatocellular carcinoma (HP:0001402)1.58439584
143Gingivitis (HP:0000230)1.58104112
144Ovoid vertebral bodies (HP:0003300)1.57490506
145Intention tremor (HP:0002080)1.57472128
146Bladder diverticulum (HP:0000015)1.56765507
147Overgrowth (HP:0001548)1.56206805
148Femoral bowing (HP:0002980)1.55778506
149Nephritis (HP:0000123)1.55682665
150Neonatal death (HP:0003811)1.55651075
151Joint hemorrhage (HP:0005261)1.55428555
152Loss of speech (HP:0002371)1.55067822
153Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.54851103
154Abnormality of the Achilles tendon (HP:0005109)1.52884864
155Spinal rigidity (HP:0003306)1.50782577
156Conjunctival telangiectasia (HP:0000524)1.50588153
157Distal upper limb amyotrophy (HP:0007149)1.50276779
158Upper limb amyotrophy (HP:0009129)1.50276779
159Congenital glaucoma (HP:0001087)1.50112046
160Tibial bowing (HP:0002982)1.49185125
161Metabolic alkalosis (HP:0200114)1.48015768
162Aplasia involving bones of the extremities (HP:0009825)1.47074582
163Aplasia of the phalanges of the hand (HP:0009802)1.47074582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.21954571
2STK393.10439272
3TRIB32.77678573
4TTN2.69410230
5EPHA22.29415194
6RIPK12.24382911
7CAMK1G2.02446456
8CAMK1D1.96623515
9AKT31.96411758
10DMPK1.90467097
11SIK11.86953416
12PTK61.82449538
13MAP3K21.79222426
14EPHA31.78790362
15ICK1.74035969
16WNK41.72586109
17LATS21.72070639
18LATS11.62199574
19MET1.56428722
20FGFR21.50992533
21IRAK31.50952512
22EEF2K1.50623270
23PDGFRA1.45801331
24DDR21.43073670
25FER1.41959705
26SCYL21.39059495
27BMX1.38834461
28KSR21.37619674
29NTRK11.37215882
30WNK11.36732564
31OXSR11.35204496
32FGR1.33607323
33RET1.28039821
34YES11.27360646
35PDGFRB1.26207408
36PKN21.24391393
37FRK1.23045939
38JAK11.22273773
39TGFBR21.22035086
40STK381.18997313
41SGK31.18253523
42MAP2K31.17514594
43MAPKAPK51.14788808
44BRD41.13938327
45FGFR31.13667544
46JAK31.12547763
47PRKD31.06764084
48STK38L1.06709490
49MAP3K61.05872450
50FGFR41.05025949
51PRPF4B1.01514951
52LRRK21.01293722
53TRPM71.00941098
54KSR11.00522653
55PTK20.97092954
56STK240.96607736
57MELK0.93304907
58IRAK10.93023464
59TIE10.92943479
60ERN10.92564623
61GSK3A0.91373015
62PAK20.90346480
63PKN10.90089067
64PDPK10.89761902
65MAP3K10.88729730
66RIPK40.88619525
67PIK3CG0.88488727
68LMTK20.88204718
69PIK3CA0.87522028
70PRKD10.87145256
71ROCK20.86986995
72PTK2B0.86894768
73PAK30.86030032
74TYK20.85669543
75SGK20.85619861
76PRKCH0.85459405
77STK100.81252629
78STK30.80962873
79NLK0.79425432
80PAK60.78919243
81TBK10.78765356
82MST1R0.78529595
83PRKAA20.78402633
84JAK20.77973698
85MST40.77330746
86PBK0.75846021
87ZAP700.75099862
88EPHB20.74754377
89ALK0.74296793
90EGFR0.74055129
91MAP3K90.74032459
92MAP3K140.73902808
93NEK90.72909835
94MAP3K70.72553069
95CDC42BPA0.72546290
96FLT30.72193528
97MOS0.70799705
98CSK0.69068482
99FYN0.68270737
100IRAK40.67433897
101CSNK1A1L0.66395827
102MAP3K130.66164750
103TYRO30.65444377
104FGFR10.65075648
105MTOR0.64861470
106BRSK20.63808311
107ERBB30.63282454
108ERBB40.62212327
109HCK0.60620562
110CDK60.58610129
111PDK10.55721559
112MARK20.55468131
113SRC0.55386753
114SGK2230.54668929
115SGK4940.54668929
116IRAK20.54523871
117ITK0.54454828
118INSR0.53084742
119DAPK20.52404874
120BMPR20.51528210
121TAOK10.50423313
122SMG10.49123463
123PRKCE0.45679011
124MAP3K30.43739901
125PAK40.43315010
126IGF1R0.43239514
127CLK10.43104400
128PRKCQ0.42800898
129CAMKK10.42691910
130LIMK10.42636032
131NEK60.42479324
132ERBB20.42252351
133CDK120.41826834
134HIPK20.41132497
135TAOK30.40823981
136RAF10.39900357
137BLK0.37769687

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.32951474
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09375217
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72722806
4Other glycan degradation_Homo sapiens_hsa005111.68309894
5Nitrogen metabolism_Homo sapiens_hsa009101.63447081
6ECM-receptor interaction_Homo sapiens_hsa045121.57563723
7Dorso-ventral axis formation_Homo sapiens_hsa043201.50840718
8Renal cell carcinoma_Homo sapiens_hsa052111.50427228
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.49263767
10Amoebiasis_Homo sapiens_hsa051461.47464500
11Focal adhesion_Homo sapiens_hsa045101.46566758
12Lysosome_Homo sapiens_hsa041421.37946021
13Leishmaniasis_Homo sapiens_hsa051401.35460501
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33419895
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31298130
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30951962
17Steroid biosynthesis_Homo sapiens_hsa001001.28789209
18Non-small cell lung cancer_Homo sapiens_hsa052231.27779620
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.27111030
20Osteoclast differentiation_Homo sapiens_hsa043801.23670507
21Proteoglycans in cancer_Homo sapiens_hsa052051.21158617
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19528047
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16901053
24Adherens junction_Homo sapiens_hsa045201.15775160
25Toxoplasmosis_Homo sapiens_hsa051451.15173953
26Fatty acid biosynthesis_Homo sapiens_hsa000611.14109571
27Malaria_Homo sapiens_hsa051441.13405738
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12054210
29Thyroid cancer_Homo sapiens_hsa052161.10967139
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08280928
31Pancreatic cancer_Homo sapiens_hsa052121.07367344
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06425740
33Type II diabetes mellitus_Homo sapiens_hsa049301.06305295
34Staphylococcus aureus infection_Homo sapiens_hsa051501.06225594
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.05374156
36Phagosome_Homo sapiens_hsa041451.04062558
37TNF signaling pathway_Homo sapiens_hsa046681.01910050
38Mineral absorption_Homo sapiens_hsa049781.01445048
39Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99630110
40Dilated cardiomyopathy_Homo sapiens_hsa054140.98749459
41VEGF signaling pathway_Homo sapiens_hsa043700.98618586
42Small cell lung cancer_Homo sapiens_hsa052220.98544484
43Pertussis_Homo sapiens_hsa051330.98250373
44Salmonella infection_Homo sapiens_hsa051320.98244766
45Glioma_Homo sapiens_hsa052140.98124405
46Sphingolipid signaling pathway_Homo sapiens_hsa040710.95475836
47Rheumatoid arthritis_Homo sapiens_hsa053230.95004817
48Chronic myeloid leukemia_Homo sapiens_hsa052200.94867678
49Viral myocarditis_Homo sapiens_hsa054160.94336575
50Tuberculosis_Homo sapiens_hsa051520.94050071
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.93842871
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93842480
53Inositol phosphate metabolism_Homo sapiens_hsa005620.92599374
54Gastric acid secretion_Homo sapiens_hsa049710.91967563
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89488349
56Acute myeloid leukemia_Homo sapiens_hsa052210.89435107
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88442557
58Histidine metabolism_Homo sapiens_hsa003400.88226492
59Starch and sucrose metabolism_Homo sapiens_hsa005000.87977175
60Endocytosis_Homo sapiens_hsa041440.87761265
61FoxO signaling pathway_Homo sapiens_hsa040680.86343010
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85425713
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84286612
64Platelet activation_Homo sapiens_hsa046110.83736458
65Renin-angiotensin system_Homo sapiens_hsa046140.83051524
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83006567
67Insulin resistance_Homo sapiens_hsa049310.82416860
68Chemokine signaling pathway_Homo sapiens_hsa040620.80005895
69Renin secretion_Homo sapiens_hsa049240.79983904
70Axon guidance_Homo sapiens_hsa043600.78917898
71N-Glycan biosynthesis_Homo sapiens_hsa005100.77362706
72Tight junction_Homo sapiens_hsa045300.77351978
73ABC transporters_Homo sapiens_hsa020100.76469271
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75638390
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75596368
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75569463
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75486085
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74910227
79Insulin signaling pathway_Homo sapiens_hsa049100.74092713
80Rap1 signaling pathway_Homo sapiens_hsa040150.73749647
81Salivary secretion_Homo sapiens_hsa049700.73738838
82TGF-beta signaling pathway_Homo sapiens_hsa043500.73172915
83Thyroid hormone synthesis_Homo sapiens_hsa049180.73088975
84Prostate cancer_Homo sapiens_hsa052150.72909093
85PPAR signaling pathway_Homo sapiens_hsa033200.72856402
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.72002408
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.71577362
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71157561
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.70392847
90Legionellosis_Homo sapiens_hsa051340.70360699
91Notch signaling pathway_Homo sapiens_hsa043300.70130615
92Estrogen signaling pathway_Homo sapiens_hsa049150.69991644
93Hepatitis B_Homo sapiens_hsa051610.69893492
94Protein digestion and absorption_Homo sapiens_hsa049740.68874472
95Galactose metabolism_Homo sapiens_hsa000520.68538377
96MicroRNAs in cancer_Homo sapiens_hsa052060.67528646
97mTOR signaling pathway_Homo sapiens_hsa041500.66998702
98Sulfur metabolism_Homo sapiens_hsa009200.65732360
99Hepatitis C_Homo sapiens_hsa051600.65611627
100Pathways in cancer_Homo sapiens_hsa052000.64191855
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63744506
102B cell receptor signaling pathway_Homo sapiens_hsa046620.63696169
103Influenza A_Homo sapiens_hsa051640.63560131
104Bile secretion_Homo sapiens_hsa049760.63557765
105Shigellosis_Homo sapiens_hsa051310.63545345
106Asthma_Homo sapiens_hsa053100.63457740
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62752625
108Prolactin signaling pathway_Homo sapiens_hsa049170.61210395
109Colorectal cancer_Homo sapiens_hsa052100.61075794
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59506380
111Fatty acid elongation_Homo sapiens_hsa000620.59420151
112Pancreatic secretion_Homo sapiens_hsa049720.59320858
113ErbB signaling pathway_Homo sapiens_hsa040120.59140941
114HIF-1 signaling pathway_Homo sapiens_hsa040660.58517095
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57991622
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57821640
117Bladder cancer_Homo sapiens_hsa052190.57701373
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.57393407
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.57123605
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56921196
121Phenylalanine metabolism_Homo sapiens_hsa003600.56682915
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56616403
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56179838
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56075438
125Ether lipid metabolism_Homo sapiens_hsa005650.55774086
126Sphingolipid metabolism_Homo sapiens_hsa006000.55499895
127Choline metabolism in cancer_Homo sapiens_hsa052310.55453455
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55422795
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55263982
130Endometrial cancer_Homo sapiens_hsa052130.55143491
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.55136681
132Prion diseases_Homo sapiens_hsa050200.55095507
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54561817
134GnRH signaling pathway_Homo sapiens_hsa049120.54356364
135Ras signaling pathway_Homo sapiens_hsa040140.54157322
136Apoptosis_Homo sapiens_hsa042100.52680237
137AMPK signaling pathway_Homo sapiens_hsa041520.52478193

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