CPEB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.03367039
2central nervous system myelination (GO:0022010)4.03367039
3acrosome reaction (GO:0007340)3.67994369
4sperm motility (GO:0030317)3.52689240
5fatty acid elongation (GO:0030497)3.43369798
6synaptic vesicle maturation (GO:0016188)3.36559627
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34985015
8gamma-aminobutyric acid transport (GO:0015812)3.31649160
9fusion of sperm to egg plasma membrane (GO:0007342)3.14737596
10neuron cell-cell adhesion (GO:0007158)3.10772114
11negative regulation of inclusion body assembly (GO:0090084)3.07163391
12long-chain fatty acid biosynthetic process (GO:0042759)3.06528642
13locomotory exploration behavior (GO:0035641)3.06350688
14L-amino acid import (GO:0043092)3.04639435
15glutamate secretion (GO:0014047)2.96863520
16neuronal action potential propagation (GO:0019227)2.95735663
17regulation of T-helper 2 cell differentiation (GO:0045628)2.95283557
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94824464
19calcium ion-dependent exocytosis (GO:0017156)2.94350411
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91953890
21regulation of synaptic vesicle exocytosis (GO:2000300)2.89359861
22response to methylmercury (GO:0051597)2.88785624
23detection of molecule of bacterial origin (GO:0032490)2.86408343
24dendrite morphogenesis (GO:0048813)2.75323699
25synaptic vesicle exocytosis (GO:0016079)2.73655578
26L-phenylalanine catabolic process (GO:0006559)2.73458426
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.73458426
28vocalization behavior (GO:0071625)2.73214171
29ensheathment of neurons (GO:0007272)2.69367459
30axon ensheathment (GO:0008366)2.69367459
31response to peptidoglycan (GO:0032494)2.68988818
32ionotropic glutamate receptor signaling pathway (GO:0035235)2.68929388
33myelination (GO:0042552)2.68593031
34negative regulation of neurotransmitter secretion (GO:0046929)2.68086693
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.68023499
36acrosome assembly (GO:0001675)2.63754251
37layer formation in cerebral cortex (GO:0021819)2.62944392
38cilium or flagellum-dependent cell motility (GO:0001539)2.62918468
39macrophage activation involved in immune response (GO:0002281)2.62739215
40multicellular organism reproduction (GO:0032504)2.60894903
41cellular response to nerve growth factor stimulus (GO:1990090)2.60893809
42response to nerve growth factor (GO:1990089)2.60893809
43cell wall macromolecule metabolic process (GO:0044036)2.58329803
44cell wall macromolecule catabolic process (GO:0016998)2.58329803
45negative regulation of neurotransmitter transport (GO:0051589)2.57605225
46dendritic spine morphogenesis (GO:0060997)2.57290910
47cellular potassium ion homeostasis (GO:0030007)2.56381894
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55865606
49plasma membrane fusion (GO:0045026)2.54086346
50protein localization to synapse (GO:0035418)2.53448793
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51721352
52neurotransmitter secretion (GO:0007269)2.51029426
53cerebellar granule cell differentiation (GO:0021707)2.47626473
54response to muramyl dipeptide (GO:0032495)2.45915904
55glycine transport (GO:0015816)2.45148597
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.43740247
57regulation of synaptic vesicle transport (GO:1902803)2.42264184
58positive regulation of p38MAPK cascade (GO:1900745)2.41711331
59regulation of glutamate receptor signaling pathway (GO:1900449)2.41071874
60neuromuscular process controlling posture (GO:0050884)2.40391764
61transmission of nerve impulse (GO:0019226)2.39880494
62membrane depolarization during action potential (GO:0086010)2.39794659
63regulation of fever generation (GO:0031620)2.39322182
64mating behavior (GO:0007617)2.38755017
65vesicle transport along microtubule (GO:0047496)2.38431266
66regulation of neuronal synaptic plasticity (GO:0048168)2.38368596
67presynaptic membrane assembly (GO:0097105)2.37181199
68glutamate receptor signaling pathway (GO:0007215)2.35834971
69sperm capacitation (GO:0048240)2.35676485
70neuron recognition (GO:0008038)2.34180371
71nerve growth factor signaling pathway (GO:0038180)2.33915411
72epithelial cilium movement (GO:0003351)2.33797553
73adult walking behavior (GO:0007628)2.32230930
74neurotransmitter-gated ion channel clustering (GO:0072578)2.30893748
75presynaptic membrane organization (GO:0097090)2.30875469
76exploration behavior (GO:0035640)2.30830676
77reproduction (GO:0000003)2.29688059
78cerebellar Purkinje cell differentiation (GO:0021702)2.29217556
79negative regulation of type 2 immune response (GO:0002829)2.28773473
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.28451003
81proline transport (GO:0015824)2.28268212
82regulation of type 2 immune response (GO:0002828)2.27928621
83protein localization to endosome (GO:0036010)2.27233848
84positive regulation of cellular amide metabolic process (GO:0034250)2.26542707
85sodium ion export (GO:0071436)2.25956519
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.25689115
87L-phenylalanine metabolic process (GO:0006558)2.25689115
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.25538205
89organelle transport along microtubule (GO:0072384)2.25383619
90establishment of mitochondrion localization (GO:0051654)2.25286174
91positive regulation of type 2 immune response (GO:0002830)2.24340084
92amino acid import (GO:0043090)2.24097223
93germinal center formation (GO:0002467)2.23785960
94positive regulation by symbiont of host defense response (GO:0052509)2.23701741
95modulation by symbiont of host defense response (GO:0052031)2.23701741
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.23701741
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.23701741
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.23701741
99modulation by symbiont of host immune response (GO:0052553)2.23701741
100macroautophagy (GO:0016236)2.23204173
101regulation of synapse structural plasticity (GO:0051823)2.22899647
102import into cell (GO:0098657)2.22469117
103neuron-neuron synaptic transmission (GO:0007270)2.21927074
104neurotransmitter transport (GO:0006836)2.19854871
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.19684560
106Rap protein signal transduction (GO:0032486)2.19636436
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.19042193
108synaptic transmission, glutamatergic (GO:0035249)2.18611582
109pyrimidine nucleobase catabolic process (GO:0006208)2.17993943
110neuronal ion channel clustering (GO:0045161)2.17427069
111regulation of NFAT protein import into nucleus (GO:0051532)2.17262208
112cell migration in hindbrain (GO:0021535)2.17004882
113neuromuscular process controlling balance (GO:0050885)2.16943418
114potassium ion import (GO:0010107)2.16854418
115behavioral response to cocaine (GO:0048148)2.16744030
116regulation of dendritic spine morphogenesis (GO:0061001)2.16076120
117long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.15206974
118axonemal dynein complex assembly (GO:0070286)2.13790230
119neurotransmitter catabolic process (GO:0042135)2.13525486
120prepulse inhibition (GO:0060134)2.13480934
121activation of protein kinase A activity (GO:0034199)2.13177789
122regulation of synaptic transmission, glutamatergic (GO:0051966)2.12193502
123lipopolysaccharide-mediated signaling pathway (GO:0031663)2.10934469
124positive regulation of heat generation (GO:0031652)2.09905340
125protein targeting to Golgi (GO:0000042)2.09020842
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.08119728
127regulation of T-helper 1 cell differentiation (GO:0045625)2.07989722
128regulation of clathrin-mediated endocytosis (GO:2000369)2.07846408
129negative regulation of interleukin-12 production (GO:0032695)2.07639386
130positive regulation of Rap GTPase activity (GO:0032854)2.07255270
131regulation of vitamin D biosynthetic process (GO:0060556)2.04517570
132cell adhesion mediated by integrin (GO:0033627)2.03611364
133response to manganese ion (GO:0010042)2.03576834
134regulation of p38MAPK cascade (GO:1900744)2.03425145
135detection of external biotic stimulus (GO:0098581)2.00855751
136skin morphogenesis (GO:0043589)2.00766255
137regulation of ARF protein signal transduction (GO:0032012)2.00754550
138positive regulation of macrophage cytokine production (GO:0060907)1.99839916
139cellular response to ethanol (GO:0071361)1.98307252
140interleukin-6-mediated signaling pathway (GO:0070102)1.98147115
141T-helper 1 type immune response (GO:0042088)1.97407583
142macrophage activation (GO:0042116)1.96918924
143establishment of endothelial barrier (GO:0061028)1.96556001
144response to fluid shear stress (GO:0034405)1.96121268
145regulation of macrophage cytokine production (GO:0010935)1.94282884
146detection of other organism (GO:0098543)1.93485812
147regulation of Rap GTPase activity (GO:0032317)1.92889536
148response to laminar fluid shear stress (GO:0034616)1.92344443
149stress fiber assembly (GO:0043149)1.91713907
150cellular response to epinephrine stimulus (GO:0071872)1.90957194
151negative regulation of vascular permeability (GO:0043116)1.89550718
152regulation of membrane protein ectodomain proteolysis (GO:0051043)1.88264192
153endocytic recycling (GO:0032456)1.87364574
154virion attachment to host cell (GO:0019062)1.87156807
155adhesion of symbiont to host cell (GO:0044650)1.87156807
156microglial cell activation (GO:0001774)1.86481865
157regulation of interferon-beta biosynthetic process (GO:0045357)1.86103331
158platelet-derived growth factor receptor signaling pathway (GO:0048008)1.86101618
159regulation of interleukin-8 biosynthetic process (GO:0045414)1.85363505
160regulation of cAMP-dependent protein kinase activity (GO:2000479)1.84793405
161hypotonic response (GO:0006971)1.82840582
162cellular response to thyroid hormone stimulus (GO:0097067)1.81480493
163neuron remodeling (GO:0016322)1.81059415
164Notch signaling involved in heart development (GO:0061314)1.79996462
165cell communication by electrical coupling (GO:0010644)1.79941919
166regulation of heat generation (GO:0031650)1.78140527
167cytoskeletal anchoring at plasma membrane (GO:0007016)1.77903152
168retrograde transport, vesicle recycling within Golgi (GO:0000301)1.77407357
169positive regulation of receptor recycling (GO:0001921)1.76764762
170negative regulation of interleukin-17 production (GO:0032700)1.76406797
171negative regulation of NF-kappaB import into nucleus (GO:0042347)1.75952429
172positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)1.75867890
173establishment of protein localization to Golgi (GO:0072600)1.75614737
174regulation of early endosome to late endosome transport (GO:2000641)1.74752475
175cortical actin cytoskeleton organization (GO:0030866)1.74489007
176establishment of skin barrier (GO:0061436)1.73995690
177early endosome to late endosome transport (GO:0045022)1.73508519
178type I interferon signaling pathway (GO:0060337)1.73316282
179cellular response to type I interferon (GO:0071357)1.73316282
180barbed-end actin filament capping (GO:0051016)1.73238296
181negative regulation of calcium ion-dependent exocytosis (GO:0045955)1.72608048
182synaptic vesicle docking involved in exocytosis (GO:0016081)1.71825522
183detection of biotic stimulus (GO:0009595)1.71753532
184response to type I interferon (GO:0034340)1.71371019
185negative regulation of erythrocyte differentiation (GO:0045647)1.71128198
186neutrophil mediated immunity (GO:0002446)1.70637496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.40329222
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.82062746
3GBX2_23144817_ChIP-Seq_PC3_Human2.52552738
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31007997
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.03388664
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96483703
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93042528
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92999381
9* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90638455
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86455162
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86188938
12TAF15_26573619_Chip-Seq_HEK293_Human1.85118704
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81954945
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.79692326
15* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71674195
16REST_21632747_ChIP-Seq_MESCs_Mouse1.70329842
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70276651
18* VDR_24787735_ChIP-Seq_THP-1_Human1.67675000
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66649116
20DROSHA_22980978_ChIP-Seq_HELA_Human1.66208312
21AR_21572438_ChIP-Seq_LNCaP_Human1.66192560
22* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65493516
23* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65493516
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63479391
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60320132
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60267920
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59130073
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.57465073
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52091609
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51188236
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.50542685
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50327488
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50189223
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49850052
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48879688
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.48838074
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48674384
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44470836
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.43991148
40CJUN_26792858_Chip-Seq_BT549_Human1.43719289
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.40491984
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38078723
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37868635
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.37810502
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.37260462
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.36917283
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.36856908
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35811903
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35624641
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31528780
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31144211
52AHR_22903824_ChIP-Seq_MCF-7_Human1.30366938
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30324378
54RUNX_20019798_ChIP-Seq_JUKART_Human1.29842725
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.28834708
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28735590
57* TP53_18474530_ChIP-ChIP_U2OS_Human1.27996538
58* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27183912
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27143897
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26690149
61VDR_22108803_ChIP-Seq_LS180_Human1.26541153
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.26039730
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.25964695
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25370377
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.24761892
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.23703776
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22569763
68* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21695596
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21517463
70* REST_18959480_ChIP-ChIP_MESCs_Mouse1.20042069
71* ARNT_22903824_ChIP-Seq_MCF-7_Human1.19271008
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17382171
73* P300_19829295_ChIP-Seq_ESCs_Human1.15406925
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.13799366
75* STAT3_23295773_ChIP-Seq_U87_Human1.12621339
76AR_25329375_ChIP-Seq_VCAP_Human1.12360749
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11714245
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.11665731
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11258254
80ER_23166858_ChIP-Seq_MCF-7_Human1.11103120
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.10478232
82* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09641978
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09099538
84TP63_23658742_ChIP-Seq_EP156T_Human1.08926482
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07483802
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07249877
87ZNF274_21170338_ChIP-Seq_K562_Hela1.07021398
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.06242906
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.04968088
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04556241
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04410604
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04395701
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03927201
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02541111
95* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02352552
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02218017
97* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02177611
98TCF4_23295773_ChIP-Seq_U87_Human1.02003371
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01315435
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00623326
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00069082
102RXR_22108803_ChIP-Seq_LS180_Human0.99570399
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99382974
104FOXO3_23340844_ChIP-Seq_DLD1_Human0.98707293
105* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98664554
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98525679
107* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98260592
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98095569
109* KDM2B_26808549_Chip-Seq_REH_Human0.97914367
110* KDM2B_26808549_Chip-Seq_K562_Human0.97486485
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97284745
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96393702
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96326352
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96237538
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95778942
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95128741
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95128741
118BCAT_22108803_ChIP-Seq_LS180_Human0.94521883
119TP53_16413492_ChIP-PET_HCT116_Human0.94411534
120* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93494007
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92845605
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92743583
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92380124
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92346654
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.92118842
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.91560454
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91346829
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.91325437
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91198962
130GATA1_22025678_ChIP-Seq_K562_Human0.91017395
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90416878
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90394622
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90394622
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89755118
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.89366597
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89356169
137* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88413918
138BRD4_25478319_ChIP-Seq_HGPS_Human0.88042880
139FOXA2_19822575_ChIP-Seq_HepG2_Human0.87984235
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87825136
141TBL1_22424771_ChIP-Seq_293T_Human0.87460264
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87359644
143* RUNX2_22187159_ChIP-Seq_PCA_Human0.87112081
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87094124
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.86821611
146FLI1_21867929_ChIP-Seq_TH2_Mouse0.86571783
147CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86097745
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86040208
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85814204
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85440441
151* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84744974
152RING1B_27294783_Chip-Seq_ESCs_Mouse0.84583413
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.83882392
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83152716
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.83100139
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82894957
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82894957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.07726507
2MP0004859_abnormal_synaptic_plasticity3.95310814
3MP0003303_peritoneal_inflammation3.67987614
4MP0004270_analgesia3.44711044
5MP0003880_abnormal_central_pattern2.98329290
6MP0004510_myositis2.92715219
7MP0009046_muscle_twitch2.79496898
8MP0003635_abnormal_synaptic_transmissio2.71492654
9MP0003329_amyloid_beta_deposits2.66533154
10MP0000920_abnormal_myelination2.62655898
11MP0003724_increased_susceptibility_to2.51536201
12MP0003300_gastrointestinal_ulcer2.50285743
13MP0003690_abnormal_glial_cell2.45366138
14MP0002064_seizures2.41201296
15MP0002139_abnormal_hepatobiliary_system2.30607948
16MP0009745_abnormal_behavioral_response2.28475804
17MP0001486_abnormal_startle_reflex2.27347134
18MP0006082_CNS_inflammation2.26914719
19MP0003091_abnormal_cell_migration2.24673041
20MP0002063_abnormal_learning/memory/cond2.15102024
21MP0005275_abnormal_skin_tensile2.13137736
22MP0008438_abnormal_cutaneous_collagen2.12222940
23MP0001968_abnormal_touch/_nociception2.08261396
24MP0002272_abnormal_nervous_system2.06106551
25MP0005423_abnormal_somatic_nervous2.04148333
26MP0005360_urolithiasis2.01670111
27MP0005058_abnormal_lysosome_morphology1.99238561
28MP0002734_abnormal_mechanical_nocicepti1.98264120
29MP0002877_abnormal_melanocyte_morpholog1.97430276
30MP0005085_abnormal_gallbladder_physiolo1.94724993
31MP0003279_aneurysm1.90448627
32MP0002822_catalepsy1.88515538
33MP0000604_amyloidosis1.87713156
34MP0002572_abnormal_emotion/affect_behav1.85310608
35MP0008004_abnormal_stomach_pH1.85067435
36MP0001958_emphysema1.77464432
37MP0002332_abnormal_exercise_endurance1.77257173
38MP0004885_abnormal_endolymph1.76704573
39MP0001440_abnormal_grooming_behavior1.72640839
40MP0003436_decreased_susceptibility_to1.71343491
41MP0003453_abnormal_keratinocyte_physiol1.71240908
42MP0000778_abnormal_nervous_system1.67919965
43MP0002735_abnormal_chemical_nociception1.66470002
44MP0004947_skin_inflammation1.62190953
45MP0005365_abnormal_bile_salt1.61431061
46MP0002998_abnormal_bone_remodeling1.61242351
47MP0001542_abnormal_bone_strength1.59603724
48MP0008875_abnormal_xenobiotic_pharmacok1.59214691
49MP0000015_abnormal_ear_pigmentation1.58961753
50MP0003191_abnormal_cellular_cholesterol1.58545715
51MP0004742_abnormal_vestibular_system1.57834362
52MP0005171_absent_coat_pigmentation1.56334162
53MP0002067_abnormal_sensory_capabilities1.52496306
54MP0003633_abnormal_nervous_system1.50657621
55MP0002736_abnormal_nociception_after1.50409155
56MP0003634_abnormal_glial_cell1.50154882
57MP0002733_abnormal_thermal_nociception1.48526919
58MP0003828_pulmonary_edema1.44836755
59MP0003705_abnormal_hypodermis_morpholog1.43272666
60MP0008569_lethality_at_weaning1.41929733
61MP0003183_abnormal_peptide_metabolism1.40893537
62MP0001970_abnormal_pain_threshold1.38678489
63MP0003698_abnormal_male_reproductive1.36625917
64MP0002419_abnormal_innate_immunity1.36244278
65MP0005164_abnormal_response_to1.35627587
66MP0001501_abnormal_sleep_pattern1.35594557
67MP0004883_abnormal_blood_vessel1.33145947
68MP0002796_impaired_skin_barrier1.32425005
69MP0003631_nervous_system_phenotype1.30740930
70MP0006054_spinal_hemorrhage1.30510936
71MP0003950_abnormal_plasma_membrane1.30314059
72MP0002229_neurodegeneration1.28584129
73MP0000955_abnormal_spinal_cord1.26434596
74MP0005386_behavior/neurological_phenoty1.26361891
75MP0004924_abnormal_behavior1.26361891
76MP0000579_abnormal_nail_morphology1.26295079
77MP0005595_abnormal_vascular_smooth1.26230073
78MP0001533_abnormal_skeleton_physiology1.23000477
79MP0004811_abnormal_neuron_physiology1.20906534
80MP0004142_abnormal_muscle_tone1.19012694
81MP0009780_abnormal_chondrocyte_physiolo1.18676701
82MP0004484_altered_response_of1.17583430
83MP0009785_altered_susceptibility_to1.16022482
84MP0001984_abnormal_olfaction1.15791503
85MP0003045_fibrosis1.15401989
86MP0003632_abnormal_nervous_system1.14497813
87MP0003566_abnormal_cell_adhesion1.14262137
88MP0002066_abnormal_motor_capabilities/c1.13344044
89MP0004858_abnormal_nervous_system1.12432288
90MP0002882_abnormal_neuron_morphology1.12085767
91MP0000343_altered_response_to1.11917634
92MP0005451_abnormal_body_composition1.10563138
93MP0009764_decreased_sensitivity_to1.10104632
94MP0004381_abnormal_hair_follicle1.10091668
95MP0005166_decreased_susceptibility_to1.09728559
96MP0010678_abnormal_skin_adnexa1.08563164
97MP0005257_abnormal_intraocular_pressure1.06686245
98MP0001851_eye_inflammation1.03609689
99MP0002148_abnormal_hypersensitivity_rea1.03449569
100MP0002118_abnormal_lipid_homeostasis1.02985487
101MP0003656_abnormal_erythrocyte_physiolo1.02711293
102MP0003195_calcinosis1.02346490
103MP0005000_abnormal_immune_tolerance1.02020348
104MP0002557_abnormal_social/conspecific_i1.01316777
105MP0005174_abnormal_tail_pigmentation1.00894293
106MP0005387_immune_system_phenotype1.00121479
107MP0001790_abnormal_immune_system1.00121479
108MP0002184_abnormal_innervation1.00052731
109MP0010329_abnormal_lipoprotein_level0.99099137
110MP0006276_abnormal_autonomic_nervous0.98538223
111MP0000371_diluted_coat_color0.97668062
112MP0005248_abnormal_Harderian_gland0.97657411
113MP0003252_abnormal_bile_duct0.97297617
114MP0005083_abnormal_biliary_tract0.96473132
115MP0005551_abnormal_eye_electrophysiolog0.95309887
116MP0004130_abnormal_muscle_cell0.94768177
117MP0000569_abnormal_digit_pigmentation0.93657321
118MP0000647_abnormal_sebaceous_gland0.93248433
119MP0001502_abnormal_circadian_rhythm0.91110336
120MP0000751_myopathy0.90892877
121MP0005167_abnormal_blood-brain_barrier0.90870391
122MP0000767_abnormal_smooth_muscle0.90034307
123MP0005025_abnormal_response_to0.89748606
124MP0002090_abnormal_vision0.89535420
125MP0001905_abnormal_dopamine_level0.89461445
126MP0005535_abnormal_body_temperature0.89353724
127MP0001835_abnormal_antigen_presentation0.89143969
128MP0009840_abnormal_foam_cell0.87093095
129MP0004043_abnormal_pH_regulation0.86402114
130MP0002896_abnormal_bone_mineralization0.86360595
131MP0005023_abnormal_wound_healing0.86297567
132MP0001853_heart_inflammation0.86080747
133MP0000465_gastrointestinal_hemorrhage0.85895959
134MP0008874_decreased_physiological_sensi0.85713233
135MP0005623_abnormal_meninges_morphology0.85069669
136MP0001299_abnormal_eye_distance/0.84943979
137MP0005646_abnormal_pituitary_gland0.84928811
138MP0001529_abnormal_vocalization0.84782456
139MP0001177_atelectasis0.84421820
140MP0003448_altered_tumor_morphology0.84045838
141MP0003172_abnormal_lysosome_physiology0.83922234
142MP0002909_abnormal_adrenal_gland0.83247680
143MP0004085_abnormal_heartbeat0.80897492
144MP0003879_abnormal_hair_cell0.78899325
145MP0009384_cardiac_valve_regurgitation0.78183567
146MP0000747_muscle_weakness0.77931245
147MP0005409_darkened_coat_color0.77752534
148MP0002152_abnormal_brain_morphology0.76223218
149MP0010234_abnormal_vibrissa_follicle0.76211388
150MP0005332_abnormal_amino_acid0.75798947
151MP0010368_abnormal_lymphatic_system0.75397903
152MP0005388_respiratory_system_phenotype0.74521959
153MP0002133_abnormal_respiratory_system0.74521959
154MP0005390_skeleton_phenotype0.72149646
155MP0000249_abnormal_blood_vessel0.71308221
156MP0002723_abnormal_immune_serum0.71272261
157MP0004145_abnormal_muscle_electrophysio0.71013312
158MP0005076_abnormal_cell_differentiation0.70724399
159MP0000383_abnormal_hair_follicle0.69402678
160MP0001666_abnormal_nutrient_absorption0.69054057
161MP0008260_abnormal_autophagy0.69002730
162MP0001929_abnormal_gametogenesis0.68957526
163MP0003075_altered_response_to0.68763929
164MP0001963_abnormal_hearing_physiology0.68366390
165MP0004036_abnormal_muscle_relaxation0.67212464

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.87112646
2Absent/shortened dynein arms (HP:0200106)4.52617780
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.52617780
4Myokymia (HP:0002411)4.17526124
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.05108785
6Cerebral inclusion bodies (HP:0100314)3.94752067
7Supranuclear gaze palsy (HP:0000605)3.78742290
8Focal motor seizures (HP:0011153)3.71657943
9Abnormality of the corticospinal tract (HP:0002492)3.55678630
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.45205332
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.45205332
12Termporal pattern (HP:0011008)3.42560735
13Insidious onset (HP:0003587)3.42560735
14Action tremor (HP:0002345)3.41572728
15Focal seizures (HP:0007359)3.37105169
16Abnormality of liposaccharide metabolism (HP:0010968)3.21911831
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.21911831
18Abnormality of glycolipid metabolism (HP:0010969)3.21911831
19Intention tremor (HP:0002080)3.18516190
20Eczematoid dermatitis (HP:0000976)3.16319597
21Onion bulb formation (HP:0003383)3.04115566
22Progressive cerebellar ataxia (HP:0002073)3.03658221
23Spastic tetraparesis (HP:0001285)2.95331837
24Ankle clonus (HP:0011448)2.90336747
25Spastic gait (HP:0002064)2.81741362
26Dysmetria (HP:0001310)2.76974807
27Abnormal respiratory motile cilium physiology (HP:0012261)2.76580470
28Peripheral hypomyelination (HP:0007182)2.72311772
29Hyporeflexia of lower limbs (HP:0002600)2.70063791
30Disinhibition (HP:0000734)2.68792526
31Hyperventilation (HP:0002883)2.64990530
32Sensory axonal neuropathy (HP:0003390)2.64340546
33Atonic seizures (HP:0010819)2.63960072
34Optic neuritis (HP:0100653)2.57904903
35Retrobulbar optic neuritis (HP:0100654)2.57904903
36Orchitis (HP:0100796)2.53655150
37Arterial tortuosity (HP:0005116)2.49196717
38Vascular tortuosity (HP:0004948)2.48075267
39Ulnar claw (HP:0001178)2.47400616
40Mutism (HP:0002300)2.46401026
41Dysostosis multiplex (HP:0000943)2.45178808
42Tetraparesis (HP:0002273)2.44430966
43Postural instability (HP:0002172)2.44302385
44Urinary bladder sphincter dysfunction (HP:0002839)2.43829307
45Epileptic encephalopathy (HP:0200134)2.43118692
46Neuronal loss in central nervous system (HP:0002529)2.40768472
47Abnormal respiratory epithelium morphology (HP:0012253)2.38836669
48Abnormal respiratory motile cilium morphology (HP:0005938)2.38836669
49Dysdiadochokinesis (HP:0002075)2.38292558
50Deep venous thrombosis (HP:0002625)2.37181892
51Segmental peripheral demyelination/remyelination (HP:0003481)2.34745688
52Complement deficiency (HP:0004431)2.33613787
53Scanning speech (HP:0002168)2.31719883
54Progressive inability to walk (HP:0002505)2.31588372
55Generalized tonic-clonic seizures (HP:0002069)2.30795241
56Intrahepatic cholestasis (HP:0001406)2.30211771
57Hyperlipoproteinemia (HP:0010980)2.29938046
58Pheochromocytoma (HP:0002666)2.29106380
59Lower limb muscle weakness (HP:0007340)2.27274405
60Xanthomatosis (HP:0000991)2.27265169
61Nuclear cataract (HP:0100018)2.26937173
62Gaze-evoked nystagmus (HP:0000640)2.25087812
63Urinary urgency (HP:0000012)2.23531463
64Clumsiness (HP:0002312)2.22656746
65Infertility (HP:0000789)2.22573652
66Peritonitis (HP:0002586)2.22433193
67Dialeptic seizures (HP:0011146)2.21194684
68Epidermoid cyst (HP:0200040)2.20486277
69Visual hallucinations (HP:0002367)2.19365306
70Decreased motor nerve conduction velocity (HP:0003431)2.17325221
71Increased IgE level (HP:0003212)2.17322384
72Absence seizures (HP:0002121)2.16617538
73Aplasia involving bones of the upper limbs (HP:0009823)2.15445973
74Aplasia of the phalanges of the hand (HP:0009802)2.15445973
75Aplasia involving bones of the extremities (HP:0009825)2.15445973
76Abnormal ciliary motility (HP:0012262)2.13278896
77Impaired vibration sensation in the lower limbs (HP:0002166)2.13064224
78Abnormality of saccadic eye movements (HP:0000570)2.11904940
79Morphological abnormality of the pyramidal tract (HP:0002062)2.11507535
80Cubitus valgus (HP:0002967)2.10768805
81Asymmetric septal hypertrophy (HP:0001670)2.10684490
82Hemiparesis (HP:0001269)2.08528958
83Apathy (HP:0000741)2.08507851
84Truncal ataxia (HP:0002078)2.08139316
85Mucopolysacchariduria (HP:0008155)2.07437340
86Urinary glycosaminoglycan excretion (HP:0003541)2.07437340
87Rhinitis (HP:0012384)2.06029976
88Protrusio acetabuli (HP:0003179)2.05505575
89Drooling (HP:0002307)2.05220914
90Excessive salivation (HP:0003781)2.05220914
91Peripheral demyelination (HP:0011096)2.04608698
92Hypoplasia of the iris (HP:0007676)2.03409893
93Myositis (HP:0100614)2.03202431
94Spondylolisthesis (HP:0003302)2.01961106
95Slow saccadic eye movements (HP:0000514)2.01890419
96Recurrent bacterial skin infections (HP:0005406)2.00198338
97Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99635722
98Atrophic scars (HP:0001075)1.99580758
99Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99282615
100Abnormality of polysaccharide metabolism (HP:0011012)1.99282615
101Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99282615
102Mitral stenosis (HP:0001718)1.98681497
103Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.98638890
104Akinesia (HP:0002304)1.98118701
105Abnormality of macrophages (HP:0004311)1.97606200
106Genetic anticipation (HP:0003743)1.96720870
107Hammertoe (HP:0001765)1.96237039
108Aortic aneurysm (HP:0004942)1.96055067
109Inappropriate behavior (HP:0000719)1.94489060
110Torticollis (HP:0000473)1.94150488
111Diminished motivation (HP:0000745)1.93865983
112Parakeratosis (HP:0001036)1.93675339
113Neonatal short-limb short stature (HP:0008921)1.93216113
114Febrile seizures (HP:0002373)1.92455561
115Loss of speech (HP:0002371)1.91998928
116Abnormal eating behavior (HP:0100738)1.91610914
117Generalized myoclonic seizures (HP:0002123)1.91393254
118Vertebral arch anomaly (HP:0008438)1.91225680
119Cerebral hemorrhage (HP:0001342)1.90789697
120Abnormal gallbladder physiology (HP:0012438)1.90479015
121Cholecystitis (HP:0001082)1.90479015
122Amyloidosis (HP:0011034)1.89105680
123Distal sensory impairment (HP:0002936)1.89060855
124Clonus (HP:0002169)1.88917651
125Exercise-induced myalgia (HP:0003738)1.88621225
126Thick nail (HP:0001805)1.84434540
127Premature rupture of membranes (HP:0001788)1.84319139
128Broad-based gait (HP:0002136)1.84104570
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83651057
130Absent frontal sinuses (HP:0002688)1.83076460
131Blue irides (HP:0000635)1.82823732
132Aortic dissection (HP:0002647)1.82652566
133Keratoconjunctivitis sicca (HP:0001097)1.81323382
134Increased CSF protein (HP:0002922)1.81310655
135Neuroendocrine neoplasm (HP:0100634)1.81300306
136Difficulty running (HP:0009046)1.79490478
137Abnormality of vision evoked potentials (HP:0000649)1.79430253
138Impaired social interactions (HP:0000735)1.79393968
139Abnormal social behavior (HP:0012433)1.79393968
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.79222979
141Osteolytic defects of the hand bones (HP:0009699)1.79222979
142Status epilepticus (HP:0002133)1.78715080
143Foot dorsiflexor weakness (HP:0009027)1.78221852
144Wormian bones (HP:0002645)1.78030564
145Steppage gait (HP:0003376)1.77154109
146Generalized hypopigmentation of hair (HP:0011358)1.76976918
147Axonal loss (HP:0003447)1.75617352
148Thoracolumbar scoliosis (HP:0002944)1.75601696
149Abnormality of the axillary hair (HP:0100134)1.74305635
150Abnormality of secondary sexual hair (HP:0009888)1.74305635
151Spontaneous hematomas (HP:0007420)1.73344282
152Diplopia (HP:0000651)1.73279819
153Abnormality of binocular vision (HP:0011514)1.73279819
154Postural tremor (HP:0002174)1.72887888
155Abnormality of the lower motor neuron (HP:0002366)1.72814605
156Overgrowth (HP:0001548)1.71802140
157Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71409487
158Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71374842
159Papilledema (HP:0001085)1.71337461
160Ventricular fibrillation (HP:0001663)1.69449158
161Cerebral aneurysm (HP:0004944)1.67277355
162Papillary thyroid carcinoma (HP:0002895)1.67135430
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65713982
164Gangrene (HP:0100758)1.65690255
165Interstitial pulmonary disease (HP:0006530)1.65427832
166Hypercortisolism (HP:0001578)1.64435030
167Rapidly progressive (HP:0003678)1.64269056
168Hemiplegia (HP:0002301)1.64049582
169Keratoconjunctivitis (HP:0001096)1.63123580
170Ocular albinism (HP:0001107)1.63069965
171Recurrent abscess formation (HP:0002722)1.60696481
172Curly hair (HP:0002212)1.60577619
173Cranial hyperostosis (HP:0004437)1.60276507
174Obstructive sleep apnea (HP:0002870)1.58613783
175Abnormality of the frontal sinuses (HP:0002687)1.58174509
176Genu recurvatum (HP:0002816)1.56841921
177Dilatation of the ascending aorta (HP:0005111)1.54807801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.61830276
2MARK12.67646290
3MAP3K92.57430122
4PDK32.44914383
5PDK42.44914383
6RIPK12.29200485
7OXSR12.28839483
8MOS2.22500249
9PRKD32.19100768
10PNCK2.17450425
11NTRK32.16459646
12EPHA42.06294361
13DDR22.05601096
14NTRK12.00213021
15ICK1.98406877
16PAK61.89879088
17WNK41.86633208
18MAP3K41.84118478
19WNK11.79013127
20PDK21.75732894
21STK241.74590835
22PKN11.66532993
23EPHB11.62622993
24NTRK21.61401772
25MAP2K41.59117687
26CASK1.58458715
27MAP3K141.57178327
28FGFR21.56526758
29MINK11.55959353
30CAMK1G1.55342628
31MAP3K31.50039487
32TYRO31.48143617
33BLK1.47779423
34MAP3K21.43393926
35KSR21.43266807
36MAP3K131.39461727
37PHKG21.38919029
38PHKG11.38919029
39DAPK21.38472447
40JAK11.36016537
41IRAK31.33596856
42NEK91.32964592
43PDGFRA1.32116164
44MAPK71.28524190
45BMPR21.27798451
46MAP2K71.25158806
47SGK2231.24179422
48SGK4941.24179422
49TGFBR21.22014636
50STK381.19426684
51IRAK41.18569973
52RIPK41.16072860
53CDK51.15735539
54PDGFRB1.13889530
55MAP3K61.12536109
56PAK31.11188813
57BCR1.07559905
58PTK2B1.07195808
59PIK3CG1.06868907
60PDPK11.04461619
61IKBKE1.03498037
62MAPKAPK51.02955957
63TBK11.02922029
64PDK11.00215438
65STK110.99400839
66TESK10.98411023
67CSNK1G20.98299709
68CSK0.96261044
69TNIK0.95410571
70GRK50.91359670
71CAMKK10.91029382
72UHMK10.90802939
73LMTK20.90216053
74CAMK2A0.88453292
75MARK30.87335698
76MARK20.87200015
77EPHA30.85464110
78FGFR30.84406331
79SIK20.83361557
80JAK20.83199081
81TYK20.82991033
82DMPK0.82945659
83LIMK10.81357493
84ERBB40.81153419
85TAOK20.80515983
86NEK60.80313042
87PRPF4B0.80262301
88PRKCG0.78499128
89RPS6KA20.76980098
90CAMK2B0.76376486
91RET0.76001897
92CSNK1A1L0.73880933
93IRAK20.73311188
94CDK190.73056563
95FGR0.72703802
96MAP3K50.69967067
97MAP2K30.69410350
98CAMK2D0.68480547
99MET0.68012877
100TRPM70.67451175
101IRAK10.66962517
102LATS10.66752566
103PINK10.66739918
104FES0.65806625
105CAMK2G0.65198751
106CAMK1D0.63434142
107MAPK130.62175960
108CDC42BPA0.61363018
109PRKCH0.61184790
110CSNK1G30.61141307
111CHUK0.61046555
112SGK10.60593332
113YES10.59743143
114PLK20.58046962
115DYRK1B0.57897666
116ZAP700.57793463
117CDK140.57611779
118ERN10.57573056
119HIPK20.57288515
120PRKCE0.57132456
121CDK120.56783712
122IKBKB0.56241538
123LATS20.56142866
124TAOK10.55244583
125BRD40.54846435
126SGK30.53901479
127PRKCZ0.53637884
128FER0.52593313
129MAPK120.52330997
130RAF10.50642760
131SGK20.50531100
132TTN0.50075688
133CDK150.49711714
134ARAF0.49207606
135ROCK20.49065203
136MAP3K10.48605793
137MAPK150.48573773
138FYN0.47545171
139KIT0.47504078
140CDK180.47271236
141PRKD10.46990418
142KSR10.46645738
143DYRK1A0.45943637
144CAMK10.45712660
145PRKG10.45538723
146SIK10.44895617
147CAMKK20.44576672
148GRK70.43287262
149MAPK40.42460475
150AKT30.41797660
151MAPK100.41723920

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.02346161
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75062407
3Synaptic vesicle cycle_Homo sapiens_hsa047211.74741215
4Primary bile acid biosynthesis_Homo sapiens_hsa001201.72384952
5Nicotine addiction_Homo sapiens_hsa050331.72156311
6GABAergic synapse_Homo sapiens_hsa047271.61924664
7Osteoclast differentiation_Homo sapiens_hsa043801.60816045
8Steroid biosynthesis_Homo sapiens_hsa001001.58934582
9Glutamatergic synapse_Homo sapiens_hsa047241.55970582
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50810683
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48375639
12Butanoate metabolism_Homo sapiens_hsa006501.47349112
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47323059
14Arginine biosynthesis_Homo sapiens_hsa002201.43844803
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42225439
16Circadian entrainment_Homo sapiens_hsa047131.41914414
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39218232
18Fatty acid elongation_Homo sapiens_hsa000621.38495916
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37532301
20Vitamin B6 metabolism_Homo sapiens_hsa007501.31852839
21TNF signaling pathway_Homo sapiens_hsa046681.30905142
22Salivary secretion_Homo sapiens_hsa049701.30001677
23Bile secretion_Homo sapiens_hsa049761.29761172
24Long-term potentiation_Homo sapiens_hsa047201.28258545
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28189705
26Malaria_Homo sapiens_hsa051441.27520034
27Fatty acid biosynthesis_Homo sapiens_hsa000611.27012703
28Morphine addiction_Homo sapiens_hsa050321.26985237
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26057731
30Amoebiasis_Homo sapiens_hsa051461.25783544
31Amphetamine addiction_Homo sapiens_hsa050311.23644919
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23587648
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21972701
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21004061
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17553653
36Tuberculosis_Homo sapiens_hsa051521.16855518
37Renin secretion_Homo sapiens_hsa049241.16177424
38Leishmaniasis_Homo sapiens_hsa051401.14746438
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.14548595
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14162300
41Olfactory transduction_Homo sapiens_hsa047401.13823361
42PPAR signaling pathway_Homo sapiens_hsa033201.13594909
43Gastric acid secretion_Homo sapiens_hsa049711.13088788
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12524671
45Ether lipid metabolism_Homo sapiens_hsa005651.12396200
46Propanoate metabolism_Homo sapiens_hsa006401.11431163
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09335013
48Fatty acid metabolism_Homo sapiens_hsa012121.09198367
49Dopaminergic synapse_Homo sapiens_hsa047281.07635099
50Axon guidance_Homo sapiens_hsa043601.05127468
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04224652
52Prolactin signaling pathway_Homo sapiens_hsa049171.03121407
53Lysosome_Homo sapiens_hsa041421.02667602
54B cell receptor signaling pathway_Homo sapiens_hsa046621.02230528
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01886464
56Insulin secretion_Homo sapiens_hsa049111.01829366
57* Dorso-ventral axis formation_Homo sapiens_hsa043201.00946467
58Pertussis_Homo sapiens_hsa051330.99779043
59VEGF signaling pathway_Homo sapiens_hsa043700.98737044
60Complement and coagulation cascades_Homo sapiens_hsa046100.98707607
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98560997
62Long-term depression_Homo sapiens_hsa047300.96918870
63Toxoplasmosis_Homo sapiens_hsa051450.96447570
64Cholinergic synapse_Homo sapiens_hsa047250.96211698
65Collecting duct acid secretion_Homo sapiens_hsa049660.95959964
66Chemokine signaling pathway_Homo sapiens_hsa040620.94279266
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.93066887
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92549565
69Cocaine addiction_Homo sapiens_hsa050300.91997663
70Phagosome_Homo sapiens_hsa041450.91931797
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91260207
72Salmonella infection_Homo sapiens_hsa051320.91018815
73Serotonergic synapse_Homo sapiens_hsa047260.90983504
74Platelet activation_Homo sapiens_hsa046110.89112879
75Glioma_Homo sapiens_hsa052140.88870392
76Focal adhesion_Homo sapiens_hsa045100.88567585
77Taste transduction_Homo sapiens_hsa047420.88423254
78Endometrial cancer_Homo sapiens_hsa052130.88345199
79Fatty acid degradation_Homo sapiens_hsa000710.88007863
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.87825013
81Histidine metabolism_Homo sapiens_hsa003400.87031134
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.85735075
83Glycerolipid metabolism_Homo sapiens_hsa005610.84932225
84Circadian rhythm_Homo sapiens_hsa047100.84909404
85Hepatitis C_Homo sapiens_hsa051600.84716145
86Type II diabetes mellitus_Homo sapiens_hsa049300.84432329
87Influenza A_Homo sapiens_hsa051640.84054649
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83890133
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.83882006
90Acute myeloid leukemia_Homo sapiens_hsa052210.83464230
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.83092268
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82914569
93FoxO signaling pathway_Homo sapiens_hsa040680.82556243
94GnRH signaling pathway_Homo sapiens_hsa049120.81877814
95African trypanosomiasis_Homo sapiens_hsa051430.81164950
96Oxytocin signaling pathway_Homo sapiens_hsa049210.81032773
97Rheumatoid arthritis_Homo sapiens_hsa053230.80986712
98Calcium signaling pathway_Homo sapiens_hsa040200.79828300
99MAPK signaling pathway_Homo sapiens_hsa040100.78377542
100mTOR signaling pathway_Homo sapiens_hsa041500.76562728
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76081469
102Pancreatic cancer_Homo sapiens_hsa052120.75811966
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75405756
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75355847
105cAMP signaling pathway_Homo sapiens_hsa040240.75157489
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75056669
107Chronic myeloid leukemia_Homo sapiens_hsa052200.73405771
108Non-small cell lung cancer_Homo sapiens_hsa052230.72980983
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72718319
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.72123721
111Rap1 signaling pathway_Homo sapiens_hsa040150.71282139
112ABC transporters_Homo sapiens_hsa020100.71170355
113Pancreatic secretion_Homo sapiens_hsa049720.71110652
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70903238
115Pyruvate metabolism_Homo sapiens_hsa006200.70423641
116Sulfur metabolism_Homo sapiens_hsa009200.70383345
117ErbB signaling pathway_Homo sapiens_hsa040120.70377527
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70363459
119Proteoglycans in cancer_Homo sapiens_hsa052050.70062367
120Hepatitis B_Homo sapiens_hsa051610.69999282
121Estrogen signaling pathway_Homo sapiens_hsa049150.69854799
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68821330
123Legionellosis_Homo sapiens_hsa051340.68606382
124Tryptophan metabolism_Homo sapiens_hsa003800.67873344
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66551020
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.66549924
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66520890
128T cell receptor signaling pathway_Homo sapiens_hsa046600.65978652
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.65954445
130Inositol phosphate metabolism_Homo sapiens_hsa005620.64147457
131Ras signaling pathway_Homo sapiens_hsa040140.63915256
132Prion diseases_Homo sapiens_hsa050200.63739436
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63725745
134Staphylococcus aureus infection_Homo sapiens_hsa051500.63042386
135Measles_Homo sapiens_hsa051620.62712722
136Gap junction_Homo sapiens_hsa045400.61910612
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61713493
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61700817
139Linoleic acid metabolism_Homo sapiens_hsa005910.61247864
140Mineral absorption_Homo sapiens_hsa049780.61100513
141ECM-receptor interaction_Homo sapiens_hsa045120.60958941
142Fat digestion and absorption_Homo sapiens_hsa049750.60880257
143Renal cell carcinoma_Homo sapiens_hsa052110.60726861
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.60671476
145Insulin signaling pathway_Homo sapiens_hsa049100.60571328
146Peroxisome_Homo sapiens_hsa041460.59302550
147Cardiac muscle contraction_Homo sapiens_hsa042600.58592816
148Sphingolipid metabolism_Homo sapiens_hsa006000.58214536
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57993544
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57734402
151Ovarian steroidogenesis_Homo sapiens_hsa049130.57458248
152Glucagon signaling pathway_Homo sapiens_hsa049220.55046038
153Endocytosis_Homo sapiens_hsa041440.54983017
154Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53602453
155beta-Alanine metabolism_Homo sapiens_hsa004100.53186116
156Steroid hormone biosynthesis_Homo sapiens_hsa001400.53022572
157Choline metabolism in cancer_Homo sapiens_hsa052310.50577509
158Chemical carcinogenesis_Homo sapiens_hsa052040.49189676
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48582826
160Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48213588
161Thyroid hormone synthesis_Homo sapiens_hsa049180.48108738

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