CPEB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.25050580
2vocalization behavior (GO:0071625)4.15569503
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14397125
4neuron cell-cell adhesion (GO:0007158)4.03362385
5synaptic vesicle exocytosis (GO:0016079)3.95695834
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85809680
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.80790403
8neuronal action potential propagation (GO:0019227)3.78997799
9locomotory exploration behavior (GO:0035641)3.78104860
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.76733404
11synaptic vesicle maturation (GO:0016188)3.76413541
12regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.70869909
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69821657
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68997185
15positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.68886486
16positive regulation of synapse maturation (GO:0090129)3.68152657
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.61670631
18regulation of synaptic vesicle exocytosis (GO:2000300)3.58149839
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.58141085
20glutamate secretion (GO:0014047)3.58041992
21adaptation of signaling pathway (GO:0023058)3.57318952
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55784481
23serotonin metabolic process (GO:0042428)3.51214431
24regulation of glutamate receptor signaling pathway (GO:1900449)3.49361830
25postsynaptic membrane organization (GO:0001941)3.49053315
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.46901239
27detection of calcium ion (GO:0005513)3.40082652
28protein localization to synapse (GO:0035418)3.37624623
29glutamate receptor signaling pathway (GO:0007215)3.34504746
30regulation of synaptic vesicle transport (GO:1902803)3.31755056
31cell communication by electrical coupling (GO:0010644)3.28127479
32cellular sodium ion homeostasis (GO:0006883)3.28123923
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23794282
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.23469558
35cellular potassium ion homeostasis (GO:0030007)3.23441735
36primary amino compound metabolic process (GO:1901160)3.22714125
37neurotransmitter secretion (GO:0007269)3.22346399
38sarcoplasmic reticulum calcium ion transport (GO:0070296)3.18521169
39gamma-aminobutyric acid transport (GO:0015812)3.17992885
40neuron recognition (GO:0008038)3.16615248
41positive regulation of potassium ion transmembrane transport (GO:1901381)3.15085248
42neuron-neuron synaptic transmission (GO:0007270)3.14621922
43pyrimidine nucleobase catabolic process (GO:0006208)3.12151803
44regulation of cell communication by electrical coupling (GO:0010649)3.12091179
45regulation of sodium ion transmembrane transporter activity (GO:2000649)3.08031980
46regulation of synapse structural plasticity (GO:0051823)3.06268579
47synaptic transmission, glutamatergic (GO:0035249)3.05849943
48membrane depolarization during action potential (GO:0086010)3.05751152
49neuromuscular synaptic transmission (GO:0007274)3.05226821
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.04350189
51cell communication involved in cardiac conduction (GO:0086065)3.03873115
52regulation of synapse maturation (GO:0090128)3.02500998
53regulation of membrane repolarization (GO:0060306)3.02394852
54transmission of nerve impulse (GO:0019226)3.01842546
55exploration behavior (GO:0035640)3.01545597
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.00736884
57positive regulation of dendritic spine morphogenesis (GO:0061003)2.99997151
58short-term memory (GO:0007614)2.97624159
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96081441
60neurotransmitter transport (GO:0006836)2.95265168
61dendritic spine morphogenesis (GO:0060997)2.95098214
62positive regulation of sodium ion transport (GO:0010765)2.94684754
63potassium ion import (GO:0010107)2.94619132
64startle response (GO:0001964)2.94458160
65regulation of neurotransmitter secretion (GO:0046928)2.93836336
66regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93713435
67positive regulation of sodium ion transmembrane transport (GO:1902307)2.93591093
68regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.93272365
69regulation of neuronal synaptic plasticity (GO:0048168)2.92523568
70sodium ion export (GO:0071436)2.91764264
71positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.90917478
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.90409512
73regulation of calcium ion transmembrane transport (GO:1903169)2.90089041
74regulation of calcium ion transmembrane transporter activity (GO:1901019)2.90089041
75response to histamine (GO:0034776)2.89409801
76negative regulation of potassium ion transmembrane transport (GO:1901380)2.88258847
77positive regulation of neurotransmitter transport (GO:0051590)2.86842363
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.86754605
79layer formation in cerebral cortex (GO:0021819)2.85887436
80neuronal action potential (GO:0019228)2.84844297
81auditory behavior (GO:0031223)2.84567175
82negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82279793
83regulation of postsynaptic membrane potential (GO:0060078)2.81657547
84activation of protein kinase A activity (GO:0034199)2.81519874
85positive regulation of potassium ion transport (GO:0043268)2.80678675
86positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.80589414
87nucleobase catabolic process (GO:0046113)2.79707245
88regulation of neurotransmitter transport (GO:0051588)2.78417738
89neuromuscular process controlling posture (GO:0050884)2.77493722
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76907401
91axonal fasciculation (GO:0007413)2.76580969
92regulation of sodium ion transmembrane transport (GO:1902305)2.76263840
93calcium ion-dependent exocytosis (GO:0017156)2.76125908
94nerve growth factor signaling pathway (GO:0038180)2.74398518
95vesicle transport along microtubule (GO:0047496)2.74380827
96* long-term memory (GO:0007616)2.74120866
97synaptic vesicle endocytosis (GO:0048488)2.72890542
98mating behavior (GO:0007617)2.72617973
99cerebellar Purkinje cell differentiation (GO:0021702)2.71663335
100proline transport (GO:0015824)2.71286644
101regulation of voltage-gated calcium channel activity (GO:1901385)2.70987934
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.70696414
103synaptic vesicle docking involved in exocytosis (GO:0016081)2.70046865
104presynaptic membrane assembly (GO:0097105)2.67268006
105membrane depolarization (GO:0051899)2.67007147
106regulation of neurotransmitter levels (GO:0001505)2.66059180
107behavioral response to cocaine (GO:0048148)2.65075367
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63689954
109neurotransmitter-gated ion channel clustering (GO:0072578)2.62347137
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.61872209
111regulation of dendritic spine morphogenesis (GO:0061001)2.61572091
112membrane hyperpolarization (GO:0060081)2.61190562
113response to epinephrine (GO:0071871)2.60906451
114adult walking behavior (GO:0007628)2.60335894
115glycine transport (GO:0015816)2.60054923
116calcium-mediated signaling using intracellular calcium source (GO:0035584)2.59341395
117positive regulation of membrane potential (GO:0045838)2.59274410
118cellular response to epinephrine stimulus (GO:0071872)2.58723165
119regulation of actin filament-based movement (GO:1903115)2.57731051
120potassium ion homeostasis (GO:0055075)2.57295048
121regulation of vesicle fusion (GO:0031338)2.56244758
122multicellular organismal signaling (GO:0035637)2.56051170
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.55559262
124presynaptic membrane organization (GO:0097090)2.54115939
125cerebellar granule cell differentiation (GO:0021707)2.53462175
126relaxation of cardiac muscle (GO:0055119)2.51857506
127cardiac muscle contraction (GO:0060048)2.51402713
128regulation of potassium ion transmembrane transport (GO:1901379)2.51299815
129mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51276810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46687627
2GBX2_23144817_ChIP-Seq_PC3_Human3.30640545
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70821861
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67726878
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54589015
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28608033
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28608033
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25198507
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21115700
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20176096
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.19207544
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17512246
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.16049642
14DROSHA_22980978_ChIP-Seq_HELA_Human2.15194377
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12861748
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07860212
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.95751030
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95331111
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.92221006
20TAF15_26573619_Chip-Seq_HEK293_Human1.91515487
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.86080261
22* RNF2_27304074_Chip-Seq_ESCs_Mouse1.78834913
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75212669
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.74289597
25AR_21572438_ChIP-Seq_LNCaP_Human1.72698646
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69430890
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68660150
28SMAD4_21799915_ChIP-Seq_A2780_Human1.67906159
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67141017
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62419466
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52937804
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49885060
33* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47206046
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46250058
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46138055
36VDR_22108803_ChIP-Seq_LS180_Human1.43208274
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41573773
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.41478764
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.40392808
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39877446
41P300_19829295_ChIP-Seq_ESCs_Human1.39822711
42ZNF274_21170338_ChIP-Seq_K562_Hela1.38725677
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38547162
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.38074804
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37462883
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37385967
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33110013
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31189596
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.31185086
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.28602724
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27627205
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27203496
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27170892
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26552113
55CBP_20019798_ChIP-Seq_JUKART_Human1.25642413
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25642413
57* STAT3_23295773_ChIP-Seq_U87_Human1.25273627
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24680918
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22085804
60AR_25329375_ChIP-Seq_VCAP_Human1.20526526
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16077030
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15498544
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15138220
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13332651
65ER_23166858_ChIP-Seq_MCF-7_Human1.12803315
66TCF4_23295773_ChIP-Seq_U87_Human1.12209474
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11791054
68IGF1R_20145208_ChIP-Seq_DFB_Human1.11555047
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10647557
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08955506
71* AR_19668381_ChIP-Seq_PC3_Human1.07884572
72AHR_22903824_ChIP-Seq_MCF-7_Human1.07610617
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.07376222
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06686248
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06629774
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05779354
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.05051092
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03982196
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.02605987
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.02494082
81* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02148491
82RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01826058
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00650523
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.00553339
85P53_22387025_ChIP-Seq_ESCs_Mouse0.99649920
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99310512
87P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98714097
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98054942
89BCAT_22108803_ChIP-Seq_LS180_Human0.97853510
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.97814537
91* RUNX2_22187159_ChIP-Seq_PCA_Human0.97298116
92* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96984426
93FUS_26573619_Chip-Seq_HEK293_Human0.96608371
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.95722614
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.95596910
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95176357
97* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95166333
98* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95122800
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94657942
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.94263618
101* TAL1_26923725_Chip-Seq_HPCs_Mouse0.93348012
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93295557
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93295557
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91953839
105TP53_16413492_ChIP-PET_HCT116_Human0.91387833
106SMAD4_21741376_ChIP-Seq_EPCs_Human0.90874187
107* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90507430
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90273684
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87979431
110* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87452037
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86603897
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86060812
113RNF2_27304074_Chip-Seq_NSC_Mouse0.85826015
114KDM2B_26808549_Chip-Seq_REH_Human0.85013448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.35642196
2MP0003880_abnormal_central_pattern4.30668696
3MP0002837_dystrophic_cardiac_calcinosis3.57171142
4MP0003635_abnormal_synaptic_transmissio3.18689830
5MP0004270_analgesia3.04730826
6MP0009046_muscle_twitch2.80958322
7MP0000569_abnormal_digit_pigmentation2.74835656
8MP0003646_muscle_fatigue2.70561864
9MP0009745_abnormal_behavioral_response2.69960900
10MP0002064_seizures2.65532234
11MP0000751_myopathy2.64862303
12MP0002063_abnormal_learning/memory/cond2.46657905
13MP0004215_abnormal_myocardial_fiber2.39922315
14MP0002272_abnormal_nervous_system2.34354114
15MP0003787_abnormal_imprinting2.30679507
16MP0002572_abnormal_emotion/affect_behav2.20613935
17MP0001486_abnormal_startle_reflex2.19728845
18MP0002822_catalepsy2.18111268
19MP0005423_abnormal_somatic_nervous2.17461027
20MP0004145_abnormal_muscle_electrophysio2.16061548
21MP0001968_abnormal_touch/_nociception2.10206643
22MP0002734_abnormal_mechanical_nocicepti2.07119565
23MP0001440_abnormal_grooming_behavior2.00520097
24MP0001501_abnormal_sleep_pattern1.95132701
25MP0004036_abnormal_muscle_relaxation1.94663457
26MP0006276_abnormal_autonomic_nervous1.81859795
27MP0004084_abnormal_cardiac_muscle1.80499966
28MP0003329_amyloid_beta_deposits1.80363420
29MP0001529_abnormal_vocalization1.80022310
30MP0002067_abnormal_sensory_capabilities1.75327638
31MP0005386_behavior/neurological_phenoty1.73323828
32MP0004924_abnormal_behavior1.73323828
33MP0002735_abnormal_chemical_nociception1.71525025
34MP0002909_abnormal_adrenal_gland1.64058299
35MP0002733_abnormal_thermal_nociception1.60373676
36MP0008569_lethality_at_weaning1.58283698
37MP0009780_abnormal_chondrocyte_physiolo1.58054382
38MP0003137_abnormal_impulse_conducting1.57292523
39MP0001970_abnormal_pain_threshold1.55799402
40MP0002736_abnormal_nociception_after1.53279323
41MP0000749_muscle_degeneration1.49776667
42MP0004130_abnormal_muscle_cell1.49213809
43MP0004085_abnormal_heartbeat1.48294243
44MP0004484_altered_response_of1.44406085
45MP0004142_abnormal_muscle_tone1.43356009
46MP0008877_abnormal_DNA_methylation1.42074172
47MP0001188_hyperpigmentation1.37984961
48MP0005620_abnormal_muscle_contractility1.37414273
49MP0005330_cardiomyopathy1.36372485
50MP0000778_abnormal_nervous_system1.36183337
51MP0001905_abnormal_dopamine_level1.35998046
52MP0005646_abnormal_pituitary_gland1.35601524
53MP0004043_abnormal_pH_regulation1.34572308
54MP0005551_abnormal_eye_electrophysiolog1.32142334
55MP0002557_abnormal_social/conspecific_i1.31941415
56MP0002184_abnormal_innervation1.30718937
57MP0001984_abnormal_olfaction1.30420142
58MP0002972_abnormal_cardiac_muscle1.28018115
59MP0004885_abnormal_endolymph1.26503840
60MP0002066_abnormal_motor_capabilities/c1.26012337
61MP0000747_muscle_weakness1.25743190
62MP0000920_abnormal_myelination1.23157889
63MP0003633_abnormal_nervous_system1.21841503
64MP0001502_abnormal_circadian_rhythm1.19255446
65MP0005535_abnormal_body_temperature1.16172252
66MP0002229_neurodegeneration1.16000428
67MP0002882_abnormal_neuron_morphology1.15476461
68MP0000955_abnormal_spinal_cord1.12453380
69MP0004233_abnormal_muscle_weight1.12038727
70MP0004811_abnormal_neuron_physiology1.09144892
71MP0004087_abnormal_muscle_fiber1.09102063
72MP0003690_abnormal_glial_cell1.07726200
73MP0005645_abnormal_hypothalamus_physiol1.06902455
74MP0000013_abnormal_adipose_tissue1.06691248
75MP0002106_abnormal_muscle_physiology1.06628743
76MP0008775_abnormal_heart_ventricle1.06368434
77MP0003121_genomic_imprinting1.05590440
78MP0003195_calcinosis1.04787424
79MP0004742_abnormal_vestibular_system1.03949976
80MP0003879_abnormal_hair_cell1.02396432
81MP0003631_nervous_system_phenotype1.01601641
82MP0005670_abnormal_white_adipose1.00050788
83MP0005369_muscle_phenotype0.91566462
84MP0002269_muscular_atrophy0.91468286
85MP0003634_abnormal_glial_cell0.91440433
86MP0006138_congestive_heart_failure0.91329650
87MP0006072_abnormal_retinal_apoptosis0.90007584
88MP0004858_abnormal_nervous_system0.89676370
89MP0001986_abnormal_taste_sensitivity0.89598696
90MP0004510_myositis0.88787920
91MP0002090_abnormal_vision0.87175660
92MP0000759_abnormal_skeletal_muscle0.86193406
93MP0005410_abnormal_fertilization0.83852184
94MP0002332_abnormal_exercise_endurance0.83648509
95MP0004147_increased_porphyrin_level0.79842360
96MP0003123_paternal_imprinting0.77896869
97MP0002152_abnormal_brain_morphology0.77591236
98MP0001544_abnormal_cardiovascular_syste0.77540796
99MP0005385_cardiovascular_system_phenoty0.77540796
100MP0008874_decreased_physiological_sensi0.77099325
101MP0003122_maternal_imprinting0.76221635
102MP0002069_abnormal_eating/drinking_beha0.75994925
103MP0000631_abnormal_neuroendocrine_gland0.75294926
104MP0001485_abnormal_pinna_reflex0.75027496
105MP0000604_amyloidosis0.74091824
106MP0010386_abnormal_urinary_bladder0.72693220
107MP0003632_abnormal_nervous_system0.70819474
108MP0002876_abnormal_thyroid_physiology0.70166583
109MP0002752_abnormal_somatic_nervous0.70138169
110MP0002638_abnormal_pupillary_reflex0.69315070
111MP0008872_abnormal_physiological_respon0.68406025
112MP0001963_abnormal_hearing_physiology0.68056615
113MP0005187_abnormal_penis_morphology0.67546880
114MP0003698_abnormal_male_reproductive0.67255906
115MP0002078_abnormal_glucose_homeostasis0.64301187

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.76485716
2Myokymia (HP:0002411)4.39133223
3Focal seizures (HP:0007359)4.24898064
4Sudden death (HP:0001699)4.14618243
5Visual hallucinations (HP:0002367)4.07033680
6Muscle hypertrophy of the lower extremities (HP:0008968)3.75820213
7Calf muscle hypertrophy (HP:0008981)3.64489380
8Exercise-induced myalgia (HP:0003738)3.63847344
9Fetal akinesia sequence (HP:0001989)3.57156907
10Epileptic encephalopathy (HP:0200134)3.56403593
11Atonic seizures (HP:0010819)3.52188790
12Muscle fiber inclusion bodies (HP:0100299)3.49425608
13Syncope (HP:0001279)3.45338972
14Progressive cerebellar ataxia (HP:0002073)3.42281550
15Absence seizures (HP:0002121)3.34907556
16Nemaline bodies (HP:0003798)3.25891639
17Generalized tonic-clonic seizures (HP:0002069)3.25153665
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.22445650
19Febrile seizures (HP:0002373)3.21814524
20Prolonged QT interval (HP:0001657)3.19418498
21Atrial fibrillation (HP:0005110)3.15098755
22Pheochromocytoma (HP:0002666)3.14512271
23Dialeptic seizures (HP:0011146)3.10990717
24Neurofibrillary tangles (HP:0002185)3.07508015
25Ventricular fibrillation (HP:0001663)3.04369283
26Primary atrial arrhythmia (HP:0001692)3.02196656
27Supranuclear gaze palsy (HP:0000605)3.00674642
28Broad-based gait (HP:0002136)2.98076123
29Hyperventilation (HP:0002883)2.92145692
30Action tremor (HP:0002345)2.90780880
31Cerebral inclusion bodies (HP:0100314)2.87852483
32Bundle branch block (HP:0011710)2.86618119
33Dysdiadochokinesis (HP:0002075)2.86241124
34Abnormality of the calf musculature (HP:0001430)2.81376404
35Supraventricular tachycardia (HP:0004755)2.81206983
36Dysmetria (HP:0001310)2.80371432
37Neuroendocrine neoplasm (HP:0100634)2.74353072
38Supraventricular arrhythmia (HP:0005115)2.71638641
39Exercise-induced muscle cramps (HP:0003710)2.66986855
40Anxiety (HP:0000739)2.63281895
41Abnormal EKG (HP:0003115)2.63276884
42Muscle fiber splitting (HP:0003555)2.61298703
43Diplopia (HP:0000651)2.59692144
44Abnormality of binocular vision (HP:0011514)2.59692144
45Progressive inability to walk (HP:0002505)2.57358582
46Postural instability (HP:0002172)2.50058439
47Poor eye contact (HP:0000817)2.47621782
48Gaze-evoked nystagmus (HP:0000640)2.46850811
49Abnormality of the left ventricular outflow tract (HP:0011103)2.46529960
50Subaortic stenosis (HP:0001682)2.46529960
51Truncal ataxia (HP:0002078)2.46256891
52Hyporeflexia of lower limbs (HP:0002600)2.44196861
53Papilledema (HP:0001085)2.43241460
54Ankle clonus (HP:0011448)2.41285639
55Impaired social interactions (HP:0000735)2.40719160
56Abnormal social behavior (HP:0012433)2.40719160
57Protruding tongue (HP:0010808)2.40496344
58Central scotoma (HP:0000603)2.37593488
59Hypothermia (HP:0002045)2.32812354
60Myotonia (HP:0002486)2.32398705
61Akinesia (HP:0002304)2.32201747
62Difficulty running (HP:0009046)2.32186419
63Dysmetric saccades (HP:0000641)2.31664914
64Ventricular arrhythmia (HP:0004308)2.30795631
65Depression (HP:0000716)2.30077613
66Excessive salivation (HP:0003781)2.29538254
67Drooling (HP:0002307)2.29538254
68Rimmed vacuoles (HP:0003805)2.28942284
69Abnormality of the corticospinal tract (HP:0002492)2.28809603
70Urinary bladder sphincter dysfunction (HP:0002839)2.27641602
71Acute necrotizing encephalopathy (HP:0006965)2.26405909
72Myoglobinuria (HP:0002913)2.24173552
73Hemiparesis (HP:0001269)2.21660360
74Ventricular tachycardia (HP:0004756)2.21157960
75Frequent falls (HP:0002359)2.19266157
76Impaired vibration sensation in the lower limbs (HP:0002166)2.18627075
77Intention tremor (HP:0002080)2.18409572
78Insidious onset (HP:0003587)2.16687940
79Termporal pattern (HP:0011008)2.16687940
80Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15859805
81Degeneration of the lateral corticospinal tracts (HP:0002314)2.15859805
82Type 1 muscle fiber predominance (HP:0003803)2.14859269
83Abnormal eating behavior (HP:0100738)2.14250393
84Hyperkalemia (HP:0002153)2.14162774
85Abnormal mitochondria in muscle tissue (HP:0008316)2.14066976
86Spastic gait (HP:0002064)2.13579856
87Scanning speech (HP:0002168)2.11242644
88Sleep apnea (HP:0010535)2.10448209
89Impaired vibratory sensation (HP:0002495)2.10020321
90Genetic anticipation (HP:0003743)2.09513857
91Left ventricular hypertrophy (HP:0001712)2.07745792
92Progressive macrocephaly (HP:0004481)2.06509714
93EMG: myopathic abnormalities (HP:0003458)2.06107002
94Heart block (HP:0012722)2.03895400
95EMG: neuropathic changes (HP:0003445)2.00493808
96Gait imbalance (HP:0002141)2.00036396
97Epileptiform EEG discharges (HP:0011182)1.98444254
98Rapidly progressive (HP:0003678)1.98267919
99Limb dystonia (HP:0002451)1.97746284
100Acute encephalopathy (HP:0006846)1.97648047
101Urinary urgency (HP:0000012)1.97152349
102Hemiplegia (HP:0002301)1.96327690
103EEG with generalized epileptiform discharges (HP:0011198)1.95325962
104Ketoacidosis (HP:0001993)1.94538462
105Lower limb muscle weakness (HP:0007340)1.92690645
106Cerebral hemorrhage (HP:0001342)1.92040597
107Torticollis (HP:0000473)1.90342029
108Generalized myoclonic seizures (HP:0002123)1.89136905
109Amblyopia (HP:0000646)1.87839072
110Absent speech (HP:0001344)1.86852665
111Amyotrophic lateral sclerosis (HP:0007354)1.85376574
112Hypsarrhythmia (HP:0002521)1.83190472
113Failure to thrive in infancy (HP:0001531)1.81649594
114Mutism (HP:0002300)1.81541560
115Abnormal atrioventricular conduction (HP:0005150)1.81347382
116Inappropriate behavior (HP:0000719)1.81233571
117Bradykinesia (HP:0002067)1.81153600
118Dynein arm defect of respiratory motile cilia (HP:0012255)1.80915056
119Absent/shortened dynein arms (HP:0200106)1.80915056
120Fair hair (HP:0002286)1.80505612
121Agitation (HP:0000713)1.80202946
122Psychosis (HP:0000709)1.80192749
123Polyphagia (HP:0002591)1.80158654
124Status epilepticus (HP:0002133)1.79079738
125Mitochondrial inheritance (HP:0001427)1.77757791
126Increased circulating renin level (HP:0000848)1.77192505
127Inability to walk (HP:0002540)1.76455332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.44982155
2EPHA43.10026916
3MAP3K42.86173626
4MAP3K92.55293587
5FRK2.42829217
6PHKG22.36539937
7PHKG12.36539937
8MARK12.34543308
9MAP2K72.13196221
10PNCK2.12956932
11MAP2K42.01850686
12STK392.00828170
13PAK61.90248310
14MINK11.85093306
15NTRK21.81783227
16NTRK11.78331570
17CASK1.69663148
18OXSR11.62489182
19LMTK21.60600493
20WNK41.58975772
21MUSK1.58017379
22TNIK1.55672200
23PRKD31.52569919
24OBSCN1.51643176
25RIPK41.49050343
26PDK41.47270521
27PDK31.47270521
28MAP3K121.46348193
29PINK11.43001698
30DAPK21.41694282
31KSR21.40386708
32GRK51.36099588
33CAMK2A1.34762951
34PAK31.33001996
35CDK51.29850763
36WNK11.28341946
37STK381.26363374
38CAMK2D1.23104701
39GRK71.22785582
40INSRR1.21176652
41PKN11.12535028
42DMPK1.12240970
43UHMK11.11814409
44MAPK131.07414332
45ARAF1.07124403
46PLK21.04079463
47ERBB31.03042520
48SGK4941.02310894
49SGK2231.02310894
50CAMK41.01929453
51AKT31.01621571
52WNK31.01438409
53CAMK2B0.98892438
54CAMK1G0.91638515
55PDK20.91410502
56PTK2B0.90758323
57PRKCG0.86065315
58RET0.85469433
59FES0.85440118
60TTN0.84186340
61CAMKK10.82851355
62PIK3CA0.82596677
63CAMK10.81466974
64PRKCE0.80999475
65CAMK2G0.79247305
66MAPKAPK50.78875854
67KSR10.78757829
68PRKCZ0.77648437
69TAOK10.77119354
70LATS20.76941922
71CDK190.76570902
72PDPK10.75860316
73TYRO30.75508961
74STK110.74840780
75SGK10.74445134
76NME10.71222393
77SIK20.70498344
78MYLK0.68223041
79PRKCH0.68038504
80BMPR20.67959195
81MAPK120.67685403
82MARK20.66408395
83FGR0.66202301
84MAP3K20.66153388
85PRKG10.65038223
86PDK10.64898622
87DYRK20.64864796
88CSNK1G20.63263594
89SGK20.62999585
90PRKD10.62904672
91PRPF4B0.60686875
92ROCK20.60303791
93DYRK1A0.59286752
94CDC42BPA0.58193072
95RPS6KA30.57937430
96MAPK100.57159126
97ICK0.56802938
98MAP3K130.56584278
99FGFR20.56024175
100MAP3K70.55533935
101CDK140.55507465
102TAOK20.54715704
103MAP3K10.54656847
104CDK150.54340864
105CAMKK20.54187048
106MAP2K60.54084833
107FER0.53784683
108PRKACA0.53722716
109CDK180.53681833
110PRKAA10.53290581
111MAP3K60.51356280
112SGK30.50861460
113DAPK10.47134524
114PIK3CG0.46762212
115FGFR30.42699080
116BMPR1B0.42008101
117BRD40.40062586
118DYRK1B0.39787862
119TRIM280.39089597
120PRKAA20.39071839
121PRKACB0.37913509
122ADRBK20.36275747
123CSNK1D0.34622064
124MAPKAPK30.34277737
125PRKCQ0.32480667
126PRKCA0.32304828
127EPHA30.32255028
128CSNK1E0.32024145
129MAP4K20.31552509

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.10798298
2Synaptic vesicle cycle_Homo sapiens_hsa047212.47583172
3GABAergic synapse_Homo sapiens_hsa047272.38779769
4Cardiac muscle contraction_Homo sapiens_hsa042602.29372721
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29287633
6Circadian entrainment_Homo sapiens_hsa047132.13256360
7Glutamatergic synapse_Homo sapiens_hsa047242.10350329
8Morphine addiction_Homo sapiens_hsa050322.09810658
9Long-term potentiation_Homo sapiens_hsa047201.91885181
10Amphetamine addiction_Homo sapiens_hsa050311.91613269
11Olfactory transduction_Homo sapiens_hsa047401.87739231
12Insulin secretion_Homo sapiens_hsa049111.85299429
13Salivary secretion_Homo sapiens_hsa049701.79734676
14Oxidative phosphorylation_Homo sapiens_hsa001901.78877943
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78829206
16Taste transduction_Homo sapiens_hsa047421.69566449
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68627614
18Dopaminergic synapse_Homo sapiens_hsa047281.68150765
19Renin secretion_Homo sapiens_hsa049241.62206341
20Gastric acid secretion_Homo sapiens_hsa049711.61348570
21Collecting duct acid secretion_Homo sapiens_hsa049661.55342557
22Serotonergic synapse_Homo sapiens_hsa047261.54781732
23Dilated cardiomyopathy_Homo sapiens_hsa054141.52618411
24Calcium signaling pathway_Homo sapiens_hsa040201.49906707
25Cholinergic synapse_Homo sapiens_hsa047251.49000697
26Alzheimers disease_Homo sapiens_hsa050101.48165366
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47768861
28Parkinsons disease_Homo sapiens_hsa050121.46845878
29Cocaine addiction_Homo sapiens_hsa050301.43044596
30Oxytocin signaling pathway_Homo sapiens_hsa049211.42985936
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38088077
32Long-term depression_Homo sapiens_hsa047301.31002178
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25661663
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23707677
35Butanoate metabolism_Homo sapiens_hsa006501.22418437
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21670714
37Nitrogen metabolism_Homo sapiens_hsa009101.17842760
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16952716
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15772005
40Type II diabetes mellitus_Homo sapiens_hsa049301.15610670
41cAMP signaling pathway_Homo sapiens_hsa040241.10803070
42GnRH signaling pathway_Homo sapiens_hsa049121.08729070
43Phototransduction_Homo sapiens_hsa047441.06378281
44Propanoate metabolism_Homo sapiens_hsa006401.06187343
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05047167
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04768461
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.97428071
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96826151
49Gap junction_Homo sapiens_hsa045400.95393937
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95044800
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91183172
52Pancreatic secretion_Homo sapiens_hsa049720.89240831
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88719034
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86520374
55Huntingtons disease_Homo sapiens_hsa050160.86222378
56Vibrio cholerae infection_Homo sapiens_hsa051100.83269824
57Fatty acid elongation_Homo sapiens_hsa000620.81720098
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81349880
59Axon guidance_Homo sapiens_hsa043600.80110056
60Estrogen signaling pathway_Homo sapiens_hsa049150.79427048
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79311820
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.78541325
63Glucagon signaling pathway_Homo sapiens_hsa049220.76901561
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74696827
65Fatty acid metabolism_Homo sapiens_hsa012120.73622538
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73565415
67Circadian rhythm_Homo sapiens_hsa047100.71333041
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69677788
69Melanogenesis_Homo sapiens_hsa049160.65724154
70Regulation of autophagy_Homo sapiens_hsa041400.65392330
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65024321
72* Dorso-ventral axis formation_Homo sapiens_hsa043200.63482598
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63069899
74Pyruvate metabolism_Homo sapiens_hsa006200.61742519
75Bile secretion_Homo sapiens_hsa049760.61741166
76Fatty acid biosynthesis_Homo sapiens_hsa000610.61655426
77ErbB signaling pathway_Homo sapiens_hsa040120.61499082
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.58601156
79Histidine metabolism_Homo sapiens_hsa003400.57183263
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56887529
81Thyroid hormone synthesis_Homo sapiens_hsa049180.55820886
82mTOR signaling pathway_Homo sapiens_hsa041500.55116056
83Arginine biosynthesis_Homo sapiens_hsa002200.54620834
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.53222750
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52652566
86* Oocyte meiosis_Homo sapiens_hsa041140.52638504
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52626526
88Choline metabolism in cancer_Homo sapiens_hsa052310.52412064
89Ovarian steroidogenesis_Homo sapiens_hsa049130.51616576
90Fatty acid degradation_Homo sapiens_hsa000710.51239950
91Glioma_Homo sapiens_hsa052140.48919873
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48881577
93Insulin signaling pathway_Homo sapiens_hsa049100.47110317
94Inositol phosphate metabolism_Homo sapiens_hsa005620.46396296
95ABC transporters_Homo sapiens_hsa020100.46257033
96MAPK signaling pathway_Homo sapiens_hsa040100.46128387
97Ether lipid metabolism_Homo sapiens_hsa005650.45964291
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42858743
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41213127
100Prion diseases_Homo sapiens_hsa050200.40042938
101Linoleic acid metabolism_Homo sapiens_hsa005910.39983890
102Renal cell carcinoma_Homo sapiens_hsa052110.39912350
103Mineral absorption_Homo sapiens_hsa049780.39493102
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39196886
105Ras signaling pathway_Homo sapiens_hsa040140.38845009
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38421843
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.38388162
108Rap1 signaling pathway_Homo sapiens_hsa040150.37313968
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35741395
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.34520624
111Phenylalanine metabolism_Homo sapiens_hsa003600.33912237
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33377866
113AMPK signaling pathway_Homo sapiens_hsa041520.32803942
114Insulin resistance_Homo sapiens_hsa049310.30995401
115Carbon metabolism_Homo sapiens_hsa012000.29735714
116Prolactin signaling pathway_Homo sapiens_hsa049170.28295234
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.27796618
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26950270
119Vitamin B6 metabolism_Homo sapiens_hsa007500.26316083
120Alcoholism_Homo sapiens_hsa050340.25304310

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