CPEB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)3.20194750
2cellular response to epinephrine stimulus (GO:0071872)3.17737816
3regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10641840
4response to epinephrine (GO:0071871)3.05941097
5regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.04459976
6negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01713495
7detection of calcium ion (GO:0005513)2.99637355
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94889960
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92347686
10cellular potassium ion homeostasis (GO:0030007)2.87945974
11macroautophagy (GO:0016236)2.87279074
12positive regulation by symbiont of host defense response (GO:0052509)2.80927553
13modulation by symbiont of host defense response (GO:0052031)2.80927553
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80927553
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80927553
16positive regulation by organism of defense response of other organism involved in symbiotic interact2.80927553
17modulation by symbiont of host immune response (GO:0052553)2.80927553
18L-amino acid import (GO:0043092)2.79610382
19response to methylmercury (GO:0051597)2.75812857
20positive regulation of cellular amide metabolic process (GO:0034250)2.74931422
21positive regulation of macroautophagy (GO:0016239)2.73745516
22regulation of relaxation of muscle (GO:1901077)2.72739012
23sodium ion export (GO:0071436)2.71078914
24relaxation of cardiac muscle (GO:0055119)2.70888510
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.70825409
26regulation of ARF protein signal transduction (GO:0032012)2.69381608
27gamma-aminobutyric acid transport (GO:0015812)2.68070728
28synaptic vesicle maturation (GO:0016188)2.67329959
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67133188
30retrograde transport, vesicle recycling within Golgi (GO:0000301)2.65688700
31protoporphyrinogen IX metabolic process (GO:0046501)2.63427814
32positive regulation of glycolytic process (GO:0045821)2.60821212
33vocalization behavior (GO:0071625)2.59973647
34iron ion import (GO:0097286)2.57643790
35regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57080868
36nerve growth factor signaling pathway (GO:0038180)2.54754141
37regulation of glutamate receptor signaling pathway (GO:1900449)2.54576816
38regulation of cell communication by electrical coupling (GO:0010649)2.53811395
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53802541
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53345397
41* ionotropic glutamate receptor signaling pathway (GO:0035235)2.52822805
42regulation of energy homeostasis (GO:2000505)2.51853481
43regulation of synaptic vesicle exocytosis (GO:2000300)2.51376851
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48133125
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47976910
46synaptic vesicle exocytosis (GO:0016079)2.47469242
47regulation of clathrin-mediated endocytosis (GO:2000369)2.47349128
48glutamate secretion (GO:0014047)2.45578143
49myofibril assembly (GO:0030239)2.45292956
50regulation of protein glycosylation (GO:0060049)2.43695648
51dendrite morphogenesis (GO:0048813)2.39153583
52macrophage activation involved in immune response (GO:0002281)2.38994015
53negative regulation of hormone biosynthetic process (GO:0032353)2.38758658
54negative regulation of dendrite morphogenesis (GO:0050774)2.38147243
55cellular response to ethanol (GO:0071361)2.37411750
56interleukin-6-mediated signaling pathway (GO:0070102)2.36713575
57Golgi to endosome transport (GO:0006895)2.36147745
58* glutamate receptor signaling pathway (GO:0007215)2.35417773
59proline transport (GO:0015824)2.35218620
60negative regulation of dendrite development (GO:2000171)2.34462925
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.34293982
62inositol phosphate catabolic process (GO:0071545)2.33765268
63amino acid import (GO:0043090)2.33101875
64response to catecholamine (GO:0071869)2.30966118
65response to monoamine (GO:0071867)2.30966118
66regulation of actin filament-based movement (GO:1903115)2.30890402
67neurotransmitter-gated ion channel clustering (GO:0072578)2.30754620
68cerebellar granule cell differentiation (GO:0021707)2.30728750
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.30007305
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.29953038
71protoporphyrinogen IX biosynthetic process (GO:0006782)2.27861092
72presynaptic membrane assembly (GO:0097105)2.27176130
73regulation of beta-amyloid formation (GO:1902003)2.26182174
74regulation of synaptic vesicle transport (GO:1902803)2.24607874
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24371469
76regulation of cAMP-dependent protein kinase activity (GO:2000479)2.23574109
77regulation of cardiac muscle cell contraction (GO:0086004)2.23485659
78righting reflex (GO:0060013)2.22722936
79regulation of Rap GTPase activity (GO:0032317)2.21202690
80alanine transport (GO:0032328)2.20913323
81gas transport (GO:0015669)2.20477485
82presynaptic membrane organization (GO:0097090)2.19918576
83oxygen transport (GO:0015671)2.19482421
84dendritic spine morphogenesis (GO:0060997)2.19029313
85positive regulation of Rap GTPase activity (GO:0032854)2.18933255
86positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.17770726
87response to insecticide (GO:0017085)2.17403866
88protein K11-linked deubiquitination (GO:0035871)2.16948436
89regulation of cellular amide metabolic process (GO:0034248)2.16890233
90glucocorticoid metabolic process (GO:0008211)2.16823095
91positive regulation of heat generation (GO:0031652)2.16822287
92potassium ion import (GO:0010107)2.16646516
93vesicle transport along microtubule (GO:0047496)2.16332778
94protein localization to synapse (GO:0035418)2.16008436
95cell communication involved in cardiac conduction (GO:0086065)2.15999751
96cerebellar Purkinje cell differentiation (GO:0021702)2.15823003
97cellular sodium ion homeostasis (GO:0006883)2.15719479
98neuron cell-cell adhesion (GO:0007158)2.15711110
99cell communication by electrical coupling (GO:0010644)2.15657866
100negative regulation of complement activation (GO:0045916)2.15517509
101layer formation in cerebral cortex (GO:0021819)2.15437302
102cellular response to antibiotic (GO:0071236)2.15154620
103erythrocyte development (GO:0048821)2.13954968
104neurotransmitter secretion (GO:0007269)2.13929323
105positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.13525446
106exploration behavior (GO:0035640)2.12825195
107neuronal action potential propagation (GO:0019227)2.12061905
108protein targeting to Golgi (GO:0000042)2.12018819
109negative regulation of amino acid transport (GO:0051956)2.11941351
110cardiac muscle hypertrophy (GO:0003300)2.11859929
111positive regulation of p38MAPK cascade (GO:1900745)2.10807065
112response to lipoprotein particle (GO:0055094)2.10688320
113regulation of membrane repolarization (GO:0060306)2.10465604
114synaptic vesicle endocytosis (GO:0048488)2.09880949
115cardiac muscle contraction (GO:0060048)2.09306130
116brain morphogenesis (GO:0048854)2.08273364
117cellular response to catecholamine stimulus (GO:0071870)2.07957005
118cellular response to monoamine stimulus (GO:0071868)2.07957005
119sarcoplasmic reticulum calcium ion transport (GO:0070296)2.06926261
120positive regulation of autophagy (GO:0010508)2.06908412
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.06332204
122cellular response to nerve growth factor stimulus (GO:1990090)2.06308519
123response to nerve growth factor (GO:1990089)2.06308519
124synaptic transmission, glutamatergic (GO:0035249)2.06114573
125cellular response to toxic substance (GO:0097237)2.06046578
126positive regulation of response to extracellular stimulus (GO:0032106)2.02860063
127positive regulation of response to nutrient levels (GO:0032109)2.02860063
128regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.02680927
129regulation of excitatory postsynaptic membrane potential (GO:0060079)2.02618818
130striated muscle hypertrophy (GO:0014897)2.02374235
131long-term memory (GO:0007616)2.01857416
132regulation of sodium ion transmembrane transporter activity (GO:2000649)2.01680272
133response to host immune response (GO:0052572)2.01260785
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.01260785
135import into cell (GO:0098657)2.01133950
136cardiac conduction (GO:0061337)2.01071502
137insulin secretion (GO:0030073)1.99877266
138microglial cell activation (GO:0001774)1.99575245
139startle response (GO:0001964)1.99563694
140regulation of neuronal synaptic plasticity (GO:0048168)1.99376480
141cyclic nucleotide catabolic process (GO:0009214)1.99347694
142regulation of dendritic spine development (GO:0060998)1.99045545
143synaptic vesicle docking involved in exocytosis (GO:0016081)1.98792361
144establishment of protein localization to Golgi (GO:0072600)1.97871570
145neuromuscular process controlling balance (GO:0050885)1.97375568
146gamma-aminobutyric acid signaling pathway (GO:0007214)1.94185272
147neuron-neuron synaptic transmission (GO:0007270)1.93286978
148low-density lipoprotein particle clearance (GO:0034383)1.92117528
149regulation of amyloid precursor protein catabolic process (GO:1902991)1.92012497
150I-kappaB phosphorylation (GO:0007252)1.91821101
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.91733637
152regulation of long-term neuronal synaptic plasticity (GO:0048169)1.91310965
153positive regulation of heterotypic cell-cell adhesion (GO:0034116)1.91190075
154regulation of synapse structural plasticity (GO:0051823)1.90617773
155membrane depolarization during action potential (GO:0086010)1.90293497
156regulation of synaptic transmission, glutamatergic (GO:0051966)1.90249877
157negative regulation of neurotransmitter secretion (GO:0046929)1.90234056
158dicarboxylic acid biosynthetic process (GO:0043650)1.89257053
159long-term synaptic potentiation (GO:0060291)1.88608058
160hemoglobin metabolic process (GO:0020027)1.88554739
161regulation of postsynaptic membrane potential (GO:0060078)1.88071499
162acidic amino acid transport (GO:0015800)1.87268270
163negative regulation of neurotransmitter transport (GO:0051589)1.87115354
164L-glutamate transport (GO:0015813)1.85965146
165regulation of voltage-gated calcium channel activity (GO:1901385)1.85887268
166glycine transport (GO:0015816)1.84967595
167positive regulation of cardiac muscle hypertrophy (GO:0010613)1.84668430
168positive regulation of muscle hypertrophy (GO:0014742)1.84668430
169clathrin coat assembly (GO:0048268)1.84221906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09382497
2EZH2_22144423_ChIP-Seq_EOC_Human2.59867361
3GBX2_23144817_ChIP-Seq_PC3_Human2.48981129
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40642803
5CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93878350
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88485659
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86391666
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81439329
9SMAD_19615063_ChIP-ChIP_OVARY_Human1.80386782
10MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68595224
11DROSHA_22980978_ChIP-Seq_HELA_Human1.68320005
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65688336
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60921037
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60745432
15AR_21572438_ChIP-Seq_LNCaP_Human1.59404298
16MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57066234
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55312617
18* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54066028
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51789037
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.51584669
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50672597
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49058892
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49058892
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47773651
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.47505958
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45185958
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42904128
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42604918
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40500802
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39827787
31REST_21632747_ChIP-Seq_MESCs_Mouse1.39225572
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.39135415
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38118932
34GATA1_22025678_ChIP-Seq_K562_Human1.36453451
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34330045
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31674200
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31117217
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31117217
39* RARB_27405468_Chip-Seq_BRAIN_Mouse1.30211181
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27553647
41* LXR_22158963_ChIP-Seq_LIVER_Mouse1.27471857
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.26897435
43TP53_16413492_ChIP-PET_HCT116_Human1.26748234
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25673832
45RXR_22108803_ChIP-Seq_LS180_Human1.24616605
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.24506020
47* GATA1_19941826_ChIP-Seq_K562_Human1.23701902
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23212161
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23212161
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22568300
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22434972
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22184990
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22122249
54* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21515299
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.21400444
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20934692
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20750302
58* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20487490
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20445895
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.20193026
61P300_19829295_ChIP-Seq_ESCs_Human1.19043504
62FUS_26573619_Chip-Seq_HEK293_Human1.18690387
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18539964
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18097756
65* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17604809
66* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17540793
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17042879
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16180024
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16139028
70* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16002705
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15909998
72AR_25329375_ChIP-Seq_VCAP_Human1.15692954
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.14948374
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14806450
75P53_22387025_ChIP-Seq_ESCs_Mouse1.14525180
76STAT3_23295773_ChIP-Seq_U87_Human1.12756538
77* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12135494
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.11807679
79* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11450006
80* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11399209
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11101865
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.10851015
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10677110
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10466016
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.09954155
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.09312031
87* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08931688
88* VDR_24787735_ChIP-Seq_THP-1_Human1.08758519
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.08735841
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08626485
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08230864
92IRF8_27001747_Chip-Seq_BMDM_Mouse1.08152522
93* AHR_22903824_ChIP-Seq_MCF-7_Human1.07709552
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.07560710
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06762882
96TAF15_26573619_Chip-Seq_HEK293_Human1.05539134
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05323192
98VDR_22108803_ChIP-Seq_LS180_Human1.05238551
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04994881
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04521671
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.04146376
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04040085
103* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03910288
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03837823
105* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02679914
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02019130
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01828952
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01788648
109* FOXA2_19822575_ChIP-Seq_HepG2_Human1.01510388
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00914829
111* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00780423
112CDX2_22108803_ChIP-Seq_LS180_Human1.00042394
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99982672
114CBP_20019798_ChIP-Seq_JUKART_Human0.99921582
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99921582
116* RXR_22158963_ChIP-Seq_LIVER_Mouse0.99733397
117RUNX2_22187159_ChIP-Seq_PCA_Human0.99699905
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.99537017
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98869381
120* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98745712
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98495206
122KDM2B_26808549_Chip-Seq_REH_Human0.97601013
123* ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97592859
124* TP53_18474530_ChIP-ChIP_U2OS_Human0.97090576
125* CRX_20693478_ChIP-Seq_RETINA_Mouse0.96563921
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96560717
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96270336
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.96143173
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.95790845
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.95715082
131* GATA2_19941826_ChIP-Seq_K562_Human0.95236964
132ER_23166858_ChIP-Seq_MCF-7_Human0.95178306
133AR_19668381_ChIP-Seq_PC3_Human0.94786067
134* TCF4_23295773_ChIP-Seq_U87_Human0.94696303
135REST_18959480_ChIP-ChIP_MESCs_Mouse0.92855946
136* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91341185
137KDM2B_26808549_Chip-Seq_K562_Human0.91273554
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90054414
139IGF1R_20145208_ChIP-Seq_DFB_Human0.89993200
140* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89919829
141* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88783112
142BCAT_22108803_ChIP-Seq_LS180_Human0.88662005
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.87831883
144IRF8_22096565_ChIP-ChIP_GC-B_Human0.85865811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.18622059
2MP0003656_abnormal_erythrocyte_physiolo2.99581521
3MP0004270_analgesia2.73246731
4MP0000569_abnormal_digit_pigmentation2.67018264
5MP0002837_dystrophic_cardiac_calcinosis2.58465288
6MP0009046_muscle_twitch2.56663430
7MP0003635_abnormal_synaptic_transmissio2.48824990
8MP0003880_abnormal_central_pattern2.46860140
9MP0003690_abnormal_glial_cell2.31372871
10MP0001501_abnormal_sleep_pattern2.18294566
11MP0002064_seizures2.16901713
12MP0009745_abnormal_behavioral_response2.13990272
13MP0000604_amyloidosis2.10898940
14MP0002063_abnormal_learning/memory/cond2.05535527
15MP0009780_abnormal_chondrocyte_physiolo2.03861873
16MP0004510_myositis2.02773135
17MP0003787_abnormal_imprinting2.01333662
18MP0004215_abnormal_myocardial_fiber1.98032349
19MP0003329_amyloid_beta_deposits1.97720633
20MP0004147_increased_porphyrin_level1.96707986
21MP0003303_peritoneal_inflammation1.95728161
22MP0002735_abnormal_chemical_nociception1.88532049
23MP0001440_abnormal_grooming_behavior1.87073741
24MP0004858_abnormal_nervous_system1.86242911
25MP0003172_abnormal_lysosome_physiology1.84507636
26MP0010234_abnormal_vibrissa_follicle1.79811920
27MP0002734_abnormal_mechanical_nocicepti1.79223964
28MP0003075_altered_response_to1.79223720
29MP0002139_abnormal_hepatobiliary_system1.71905180
30MP0003195_calcinosis1.68001206
31MP0001486_abnormal_startle_reflex1.67294821
32MP0004130_abnormal_muscle_cell1.66248438
33MP0005058_abnormal_lysosome_morphology1.65960561
34MP0002572_abnormal_emotion/affect_behav1.62011636
35MP0004084_abnormal_cardiac_muscle1.61492109
36MP0003122_maternal_imprinting1.59434623
37MP0001968_abnormal_touch/_nociception1.59293322
38MP0005360_urolithiasis1.53194642
39MP0004145_abnormal_muscle_electrophysio1.46848056
40MP0003183_abnormal_peptide_metabolism1.44770912
41MP0003633_abnormal_nervous_system1.43668938
42MP0004036_abnormal_muscle_relaxation1.43642606
43MP0000920_abnormal_myelination1.41509719
44MP0005083_abnormal_biliary_tract1.41044342
45MP0002909_abnormal_adrenal_gland1.40877672
46MP0005535_abnormal_body_temperature1.40270353
47MP0005167_abnormal_blood-brain_barrier1.39097492
48MP0002272_abnormal_nervous_system1.37802692
49MP0002733_abnormal_thermal_nociception1.37530805
50MP0002067_abnormal_sensory_capabilities1.35248654
51MP0003646_muscle_fatigue1.34113669
52MP0004043_abnormal_pH_regulation1.33503763
53MP0005423_abnormal_somatic_nervous1.28866064
54MP0003300_gastrointestinal_ulcer1.27007368
55MP0002254_reproductive_system_inflammat1.24953200
56MP0006082_CNS_inflammation1.24527653
57MP0002736_abnormal_nociception_after1.22699568
58MP0008057_abnormal_DNA_replication1.22398127
59MP0002090_abnormal_vision1.22082843
60MP0004924_abnormal_behavior1.21690871
61MP0005386_behavior/neurological_phenoty1.21690871
62MP0003634_abnormal_glial_cell1.21328037
63MP0000013_abnormal_adipose_tissue1.18802550
64MP0001970_abnormal_pain_threshold1.17855575
65MP0009764_decreased_sensitivity_to1.16978520
66MP0003631_nervous_system_phenotype1.14738986
67MP0008569_lethality_at_weaning1.14577570
68MP0004885_abnormal_endolymph1.14167012
69MP0000749_muscle_degeneration1.14163106
70MP0002078_abnormal_glucose_homeostasis1.12837418
71MP0005646_abnormal_pituitary_gland1.12439687
72MP0010386_abnormal_urinary_bladder1.12032855
73MP0001502_abnormal_circadian_rhythm1.10263533
74MP0005620_abnormal_muscle_contractility1.10169974
75MP0001756_abnormal_urination1.09436205
76MP0000015_abnormal_ear_pigmentation1.07826427
77MP0000778_abnormal_nervous_system1.07031588
78MP0002822_catalepsy1.06936716
79MP0002693_abnormal_pancreas_physiology1.03969658
80MP0005166_decreased_susceptibility_to1.03337937
81MP0005248_abnormal_Harderian_gland1.02498667
82MP0000639_abnormal_adrenal_gland1.01898818
83MP0003724_increased_susceptibility_to1.01292423
84MP0002638_abnormal_pupillary_reflex1.00973488
85MP0001944_abnormal_pancreas_morphology1.00619306
86MP0005379_endocrine/exocrine_gland_phen0.99771212
87MP0002229_neurodegeneration0.99120798
88MP0003252_abnormal_bile_duct0.98840813
89MP0008004_abnormal_stomach_pH0.98048268
90MP0010329_abnormal_lipoprotein_level0.97298453
91MP0003045_fibrosis0.96884370
92MP0005174_abnormal_tail_pigmentation0.96851241
93MP0004811_abnormal_neuron_physiology0.96844882
94MP0005085_abnormal_gallbladder_physiolo0.96829272
95MP0003879_abnormal_hair_cell0.95875294
96MP0004142_abnormal_muscle_tone0.95822561
97MP0005253_abnormal_eye_physiology0.95536132
98MP0008874_decreased_physiological_sensi0.92346233
99MP0003436_decreased_susceptibility_to0.91156465
100MP0005365_abnormal_bile_salt0.90608454
101MP0003868_abnormal_feces_composition0.90513617
102MP0003632_abnormal_nervous_system0.90433550
103MP0002332_abnormal_exercise_endurance0.89736674
104MP0002118_abnormal_lipid_homeostasis0.89636321
105MP0002419_abnormal_innate_immunity0.89631059
106MP0005187_abnormal_penis_morphology0.88751397
107MP0004742_abnormal_vestibular_system0.88649399
108MP0002066_abnormal_motor_capabilities/c0.88480908
109MP0005636_abnormal_mineral_homeostasis0.85689485
110MP0003011_delayed_dark_adaptation0.84242714
111MP0008877_abnormal_DNA_methylation0.83409683
112MP0010678_abnormal_skin_adnexa0.81454700
113MP0002168_other_aberrant_phenotype0.79252565
114MP0000955_abnormal_spinal_cord0.78090712
115MP0002998_abnormal_bone_remodeling0.77585256
116MP0005448_abnormal_energy_balance0.77466092
117MP0002882_abnormal_neuron_morphology0.77316998
118MP0002971_abnormal_brown_adipose0.77303641
119MP0004484_altered_response_of0.76990367
120MP0002184_abnormal_innervation0.76226964
121MP0004085_abnormal_heartbeat0.76110901
122MP0005551_abnormal_eye_electrophysiolog0.75933915
123MP0005310_abnormal_salivary_gland0.75777187
124MP0002557_abnormal_social/conspecific_i0.75069836
125MP0008775_abnormal_heart_ventricle0.74942997
126MP0002972_abnormal_cardiac_muscle0.74669046
127MP0003191_abnormal_cellular_cholesterol0.73364720
128MP0003953_abnormal_hormone_level0.71717102
129MP0005164_abnormal_response_to0.70334234
130MP0001765_abnormal_ion_homeostasis0.69765721
131MP0005645_abnormal_hypothalamus_physiol0.69616775
132MP0008260_abnormal_autophagy0.68414929
133MP0005584_abnormal_enzyme/coenzyme_acti0.67760798
134MP0001984_abnormal_olfaction0.67649552
135MP0006276_abnormal_autonomic_nervous0.67571930

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.93085490
2Papillary thyroid carcinoma (HP:0002895)3.74206662
3Focal seizures (HP:0007359)3.57379205
4Poikilocytosis (HP:0004447)3.37849158
5Increased cerebral lipofuscin (HP:0011813)3.22196735
6Neurofibrillary tangles (HP:0002185)3.20816982
7Action tremor (HP:0002345)3.10216513
8Abnormality of the heme biosynthetic pathway (HP:0010472)3.08891974
9Epileptic encephalopathy (HP:0200134)3.05285435
10Syncope (HP:0001279)2.99455479
11Bundle branch block (HP:0011710)2.95147273
12Recurrent gram-negative bacterial infections (HP:0005420)2.94024137
13Myokymia (HP:0002411)2.93410222
14Cerebral inclusion bodies (HP:0100314)2.92998347
15Generalized tonic-clonic seizures (HP:0002069)2.88819407
16Hypochromic microcytic anemia (HP:0004840)2.87726994
17Supranuclear gaze palsy (HP:0000605)2.86516358
18Calf muscle hypertrophy (HP:0008981)2.83910003
19Visual hallucinations (HP:0002367)2.83420371
20Increased neuronal autofluorescent lipopigment (HP:0002074)2.82557718
21Difficulty running (HP:0009046)2.80665785
22Febrile seizures (HP:0002373)2.80650012
23Thyroid carcinoma (HP:0002890)2.80607526
24Axonal loss (HP:0003447)2.78569294
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.74906154
26Acanthocytosis (HP:0001927)2.74624958
27Ventricular fibrillation (HP:0001663)2.74104053
28Progressive cerebellar ataxia (HP:0002073)2.70602724
29Increased circulating renin level (HP:0000848)2.65473281
30Hyperglycemia (HP:0003074)2.63244912
31Dialeptic seizures (HP:0011146)2.61945213
32Absence seizures (HP:0002121)2.61525960
33Muscle hypertrophy of the lower extremities (HP:0008968)2.60615941
34Cholelithiasis (HP:0001081)2.56686075
35Hyporeflexia of lower limbs (HP:0002600)2.56047474
36Ketoacidosis (HP:0001993)2.51008823
37Hypothermia (HP:0002045)2.50269332
38Hemiparesis (HP:0001269)2.48362340
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48179092
40Hyperinsulinemic hypoglycemia (HP:0000825)2.47240762
41Fair hair (HP:0002286)2.45356005
42Abnormal gallbladder morphology (HP:0012437)2.44515436
43Diplopia (HP:0000651)2.44333857
44Abnormality of binocular vision (HP:0011514)2.44333857
45Excessive salivation (HP:0003781)2.42178079
46Drooling (HP:0002307)2.42178079
47EEG with generalized epileptiform discharges (HP:0011198)2.42125810
48Recurrent bacterial skin infections (HP:0005406)2.41928517
49Reticulocytosis (HP:0001923)2.41301450
50Sudden death (HP:0001699)2.39869630
51Clumsiness (HP:0002312)2.39263512
52Pheochromocytoma (HP:0002666)2.38780489
53Hyperkalemia (HP:0002153)2.38043465
54Postural instability (HP:0002172)2.35215661
55Atonic seizures (HP:0010819)2.30788105
56Hyperventilation (HP:0002883)2.30695604
57Hypsarrhythmia (HP:0002521)2.29848653
58Abnormality of the calf musculature (HP:0001430)2.28593743
59Generalized hypopigmentation of hair (HP:0011358)2.27784170
60Recurrent abscess formation (HP:0002722)2.24469081
61Dysmetria (HP:0001310)2.23770275
62Hypoglycemic seizures (HP:0002173)2.22537020
63Testicular neoplasm (HP:0010788)2.22038874
64Blue irides (HP:0000635)2.21622845
65Decreased circulating renin level (HP:0003351)2.20130427
66Muscle fiber splitting (HP:0003555)2.19843994
67Status epilepticus (HP:0002133)2.19817381
68Eczematoid dermatitis (HP:0000976)2.19760838
69Progressive inability to walk (HP:0002505)2.18030592
70Neuroendocrine neoplasm (HP:0100634)2.17652423
71Tetraparesis (HP:0002273)2.17615582
72Abnormal social behavior (HP:0012433)2.17399082
73Impaired social interactions (HP:0000735)2.17399082
74Atrial fibrillation (HP:0005110)2.16380699
75Spastic tetraparesis (HP:0001285)2.13369570
76Hypokalemic alkalosis (HP:0001949)2.10962434
77Global brain atrophy (HP:0002283)2.10603307
78Fetal akinesia sequence (HP:0001989)2.10156494
79Confusion (HP:0001289)2.10122416
80Dysdiadochokinesis (HP:0002075)2.10110118
81Ventricular arrhythmia (HP:0004308)2.09794999
82Primary atrial arrhythmia (HP:0001692)2.09496406
83Gaze-evoked nystagmus (HP:0000640)2.09341262
84Intention tremor (HP:0002080)2.08693599
85Insulin-resistant diabetes mellitus (HP:0000831)2.08051599
86Frequent falls (HP:0002359)2.07735300
87Abnormality of the left ventricular outflow tract (HP:0011103)2.07580644
88Subaortic stenosis (HP:0001682)2.07580644
89Prolonged QT interval (HP:0001657)2.07462156
90Abnormality of macrophages (HP:0004311)2.07300705
91Agitation (HP:0000713)2.07030404
92Depression (HP:0000716)2.03934576
93Broad-based gait (HP:0002136)2.03112541
94Genetic anticipation (HP:0003743)2.02488848
95Mutism (HP:0002300)2.02385825
96Urinary bladder sphincter dysfunction (HP:0002839)2.02249645
97EMG: myopathic abnormalities (HP:0003458)2.02001274
98Hypoglycemic coma (HP:0001325)1.99645735
99Inappropriate behavior (HP:0000719)1.99403187
100Widely spaced teeth (HP:0000687)1.97743555
101Disinhibition (HP:0000734)1.97585072
102Hyperaldosteronism (HP:0000859)1.97297040
103Hematochezia (HP:0002573)1.97144423
104Large for gestational age (HP:0001520)1.97079515
105Hamartoma of the eye (HP:0010568)1.97034685
106Absent speech (HP:0001344)1.96952527
107Albinism (HP:0001022)1.96352841
108Onion bulb formation (HP:0003383)1.95479369
109Neuronal loss in central nervous system (HP:0002529)1.94749967
110Anxiety (HP:0000739)1.94296140
111Dysmetric saccades (HP:0000641)1.94179761
112Abnormal EKG (HP:0003115)1.94083759
113Postural tremor (HP:0002174)1.93831227
114Truncal ataxia (HP:0002078)1.93825802
115Increased CSF protein (HP:0002922)1.93340233
116Congenital sensorineural hearing impairment (HP:0008527)1.92552495
117Microcytic anemia (HP:0001935)1.92347394
118Enlarged penis (HP:0000040)1.92082069
119Amyloidosis (HP:0011034)1.91992863
120Abnormality of calcium-phosphate metabolism (HP:0100530)1.91570535
121Poor eye contact (HP:0000817)1.90728751
122Myocardial infarction (HP:0001658)1.89759806
123Dysostosis multiplex (HP:0000943)1.88386789
124Supraventricular tachycardia (HP:0004755)1.86798019
125Hypomagnesemia (HP:0002917)1.86704834
126Abnormality of the corticospinal tract (HP:0002492)1.86461146
127Abnormality of polysaccharide metabolism (HP:0011012)1.86166899
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86166899
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86166899
130Progressive visual loss (HP:0000529)1.85713141
131Stomatitis (HP:0010280)1.84872952
132Peripheral demyelination (HP:0011096)1.84298728
133Abnormality of potassium homeostasis (HP:0011042)1.83349832
134Gingivitis (HP:0000230)1.83219709
135Retinal atrophy (HP:0001105)1.82766862
136Mucopolysacchariduria (HP:0008155)1.82691609
137Urinary glycosaminoglycan excretion (HP:0003541)1.82691609
138Protruding tongue (HP:0010808)1.82249160
139Slow saccadic eye movements (HP:0000514)1.81457589
140Exercise-induced myalgia (HP:0003738)1.80998712
141EMG: neuropathic changes (HP:0003445)1.80537978
142Abnormality of salivation (HP:0100755)1.80536141
143Macroorchidism (HP:0000053)1.78612831
144Supraventricular arrhythmia (HP:0005115)1.78277389
145Sensorimotor neuropathy (HP:0007141)1.78013499
146Epidermoid cyst (HP:0200040)1.77942131
147Insidious onset (HP:0003587)1.77756416
148Termporal pattern (HP:0011008)1.77756416
149Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77258377
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.77258377
151Abnormality of the periventricular white matter (HP:0002518)1.76972110
152Abnormality of renin-angiotensin system (HP:0000847)1.76665079
153Asymmetric septal hypertrophy (HP:0001670)1.76254144
154Abnormal eating behavior (HP:0100738)1.75799864
155Xanthomatosis (HP:0000991)1.75663552
156Psychosis (HP:0000709)1.74145864
157Abnormality of saccadic eye movements (HP:0000570)1.73588916
158Hypoalphalipoproteinemia (HP:0003233)1.73219851
159Papilledema (HP:0001085)1.71778762
160Lower limb muscle weakness (HP:0007340)1.70835160
161Thick nail (HP:0001805)1.70575002
162Hemiplegia (HP:0002301)1.70324419
163Lower limb amyotrophy (HP:0007210)1.68608875
164Abnormality of the gallbladder (HP:0005264)1.67674474
165Epileptiform EEG discharges (HP:0011182)1.66889040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.55361713
2EPHA42.68869456
3DAPK22.67319319
4NTRK32.61757316
5OBSCN2.51599697
6AKT32.45760355
7MARK12.11563321
8MAP3K91.90352147
9PAK61.74369479
10KSR21.73364183
11MAP3K41.71990088
12CAMK1G1.69557082
13MAP2K41.63000423
14NTRK11.61992668
15SGK21.60052952
16SGK31.58758597
17MAP3K141.55779502
18SGK4941.51795014
19SGK2231.51795014
20MAP3K131.50856754
21EPHA31.44795593
22MAP3K21.43901941
23TRPM71.39654969
24CAMK1D1.33966728
25PINK11.33886375
26STK241.29861831
27INSRR1.26767005
28CASK1.26250045
29TNIK1.24847036
30ACVR1B1.24481925
31FGR1.22516774
32NTRK21.21793750
33RIPK11.21582580
34ERBB41.19335260
35TAOK31.18078419
36SGK11.16962231
37MINK11.16610325
38JAK11.16395033
39CAMKK11.13596819
40MAP2K71.11664669
41MAPK131.10509525
42PTK2B1.10027133
43ERBB31.08620344
44RET1.07507951
45CDK51.06942163
46PDPK11.04884311
47PHKG21.03601692
48PHKG11.03601692
49BMX1.03254271
50CAMKK21.02529850
51FER1.01723564
52NLK1.00663496
53PKN10.99027991
54SIK20.98639930
55IRAK30.98484470
56WNK10.98347518
57PLK20.97142805
58IRAK10.95949639
59PRPF4B0.95159291
60TBK10.94502185
61PRKCH0.93672304
62YES10.91974359
63GRK50.89720992
64STK38L0.89190695
65CAMK40.88918945
66MAP3K30.86510275
67PDK10.86030057
68EPHB10.85503415
69MST1R0.83077240
70KSR10.82859140
71OXSR10.82422930
72JAK20.80691227
73IKBKE0.80458489
74PBK0.77098460
75MAPK120.75874806
76DYRK1A0.74340673
77DMPK0.74235988
78BMPR20.74071095
79PRKAA10.73159613
80PDGFRB0.70314808
81CAMK2A0.69974665
82HIPK20.69562842
83MAP3K60.69048093
84PRKCE0.68948002
85CAMK10.66192571
86FGFR20.64672455
87STK380.64656078
88BMPR1B0.64549786
89FRK0.64449729
90PRKD30.63392054
91MAP3K50.63124136
92UHMK10.62726786
93TYRO30.61284050
94FES0.61234089
95WNK40.60788600
96PRKCG0.59574168
97CAMK2D0.59527418
98PDK20.59378090
99PRKAA20.58496716
100PRKCZ0.58381413
101ABL20.58337523
102PAK30.57901293
103STK30.57868349
104MST40.57523632
105MAP2K10.57295940
106STK110.56720144
107MAP3K10.56493502
108IRAK20.56284040
109SIK10.55389920
110FGFR30.54829017
111FYN0.53870389
112MAP3K70.53576161
113BLK0.53062149
114RPS6KA30.52898105
115ERBB20.51496242
116PRKCQ0.51349125
117MAP4K20.50876114
118EIF2AK10.50346023
119TRIB30.50207941
120MARK30.49696441
121TYK20.49550067
122CHUK0.49312608
123CDC42BPA0.49001779
124WNK30.48536620
125PIK3CA0.48380046
126MAP2K30.48030317
127STK390.47690588
128EGFR0.47577501
129PRKACG0.47480102
130TAOK10.47265069
131MUSK0.47094322
132LATS10.46284329
133DAPK10.46097259
134NEK60.46045669
135GRK70.44929489
136MAPK70.44744809
137PRKG10.44249334
138PIM10.43970125
139CSNK1G20.41990382
140STK40.41108125
141CAMK2B0.39924168
142BRD40.39634151

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.31017488
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.25523630
3Nicotine addiction_Homo sapiens_hsa050331.76666699
4Synaptic vesicle cycle_Homo sapiens_hsa047211.75361625
5Type II diabetes mellitus_Homo sapiens_hsa049301.61467644
6GABAergic synapse_Homo sapiens_hsa047271.53550443
7Glutamatergic synapse_Homo sapiens_hsa047241.43544484
8Collecting duct acid secretion_Homo sapiens_hsa049661.43127519
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41831181
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39915912
11Long-term potentiation_Homo sapiens_hsa047201.39516364
12Circadian entrainment_Homo sapiens_hsa047131.38379049
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36853434
14Regulation of autophagy_Homo sapiens_hsa041401.36584034
15Morphine addiction_Homo sapiens_hsa050321.30355046
16Salivary secretion_Homo sapiens_hsa049701.30007844
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25538820
18Ovarian steroidogenesis_Homo sapiens_hsa049131.25072937
19Olfactory transduction_Homo sapiens_hsa047401.20376209
20FoxO signaling pathway_Homo sapiens_hsa040681.15206023
21Insulin secretion_Homo sapiens_hsa049111.14824914
22Arginine biosynthesis_Homo sapiens_hsa002201.10289475
23Gastric acid secretion_Homo sapiens_hsa049711.07016128
24Cholinergic synapse_Homo sapiens_hsa047251.06937894
25Bile secretion_Homo sapiens_hsa049761.06589237
26Staphylococcus aureus infection_Homo sapiens_hsa051501.05867548
27Amphetamine addiction_Homo sapiens_hsa050311.03501640
28* Dorso-ventral axis formation_Homo sapiens_hsa043201.00019859
29Rheumatoid arthritis_Homo sapiens_hsa053230.99647814
30Dopaminergic synapse_Homo sapiens_hsa047280.98177085
31Renin secretion_Homo sapiens_hsa049240.97841768
32Long-term depression_Homo sapiens_hsa047300.95552969
33Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95361914
34Prolactin signaling pathway_Homo sapiens_hsa049170.94317485
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94105185
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91732577
37Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90714158
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90174452
39Osteoclast differentiation_Homo sapiens_hsa043800.89764156
40Lysosome_Homo sapiens_hsa041420.88935324
41African trypanosomiasis_Homo sapiens_hsa051430.88850123
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88044509
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.87406147
44Tuberculosis_Homo sapiens_hsa051520.87030790
45Oxytocin signaling pathway_Homo sapiens_hsa049210.86865966
46Glucagon signaling pathway_Homo sapiens_hsa049220.86436919
47Fatty acid biosynthesis_Homo sapiens_hsa000610.86006092
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85238248
49Malaria_Homo sapiens_hsa051440.83175136
50cAMP signaling pathway_Homo sapiens_hsa040240.80691914
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80585133
52Leishmaniasis_Homo sapiens_hsa051400.80304420
53GnRH signaling pathway_Homo sapiens_hsa049120.80154351
54Serotonergic synapse_Homo sapiens_hsa047260.79202917
55Glioma_Homo sapiens_hsa052140.78586456
56Taste transduction_Homo sapiens_hsa047420.78067299
57Cocaine addiction_Homo sapiens_hsa050300.78042110
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77780875
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76747937
60AMPK signaling pathway_Homo sapiens_hsa041520.75722870
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75605883
62Calcium signaling pathway_Homo sapiens_hsa040200.75500345
63Type I diabetes mellitus_Homo sapiens_hsa049400.73292227
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.73079359
65Choline metabolism in cancer_Homo sapiens_hsa052310.72282598
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.72190302
67Insulin resistance_Homo sapiens_hsa049310.71801082
68Mineral absorption_Homo sapiens_hsa049780.71508866
69ABC transporters_Homo sapiens_hsa020100.71439699
70TNF signaling pathway_Homo sapiens_hsa046680.71223021
71PPAR signaling pathway_Homo sapiens_hsa033200.71165660
72ErbB signaling pathway_Homo sapiens_hsa040120.71142754
73Endometrial cancer_Homo sapiens_hsa052130.70976369
74Sphingolipid metabolism_Homo sapiens_hsa006000.70976160
75Complement and coagulation cascades_Homo sapiens_hsa046100.70886151
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69781849
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68481826
78Phagosome_Homo sapiens_hsa041450.66707618
79Insulin signaling pathway_Homo sapiens_hsa049100.65469705
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64715047
81Chemokine signaling pathway_Homo sapiens_hsa040620.64388036
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64233156
83Ether lipid metabolism_Homo sapiens_hsa005650.62445494
84Renal cell carcinoma_Homo sapiens_hsa052110.62234847
85Estrogen signaling pathway_Homo sapiens_hsa049150.60860548
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60492216
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.60221054
88Pancreatic secretion_Homo sapiens_hsa049720.59973701
89mTOR signaling pathway_Homo sapiens_hsa041500.59464787
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58980346
91Pertussis_Homo sapiens_hsa051330.58658955
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58637861
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57939089
94Graft-versus-host disease_Homo sapiens_hsa053320.57801807
95Amoebiasis_Homo sapiens_hsa051460.55272900
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.54872155
97Dilated cardiomyopathy_Homo sapiens_hsa054140.54274281
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.53939141
99Vitamin B6 metabolism_Homo sapiens_hsa007500.53918760
100Gap junction_Homo sapiens_hsa045400.53897278
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53092408
102Platelet activation_Homo sapiens_hsa046110.52852177
103Butanoate metabolism_Homo sapiens_hsa006500.52172491
104Circadian rhythm_Homo sapiens_hsa047100.52069950
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51814090
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51362636
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.49958233
108Prion diseases_Homo sapiens_hsa050200.49952541
109Salmonella infection_Homo sapiens_hsa051320.49819627
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49416956
111Inositol phosphate metabolism_Homo sapiens_hsa005620.49004403
112Thyroid hormone synthesis_Homo sapiens_hsa049180.48943482
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47879344
114VEGF signaling pathway_Homo sapiens_hsa043700.47776989
115MAPK signaling pathway_Homo sapiens_hsa040100.47706854
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47671533
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47666894
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47444920
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46398279
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45221651
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44716387
122Axon guidance_Homo sapiens_hsa043600.43846963
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43401336
124Fatty acid metabolism_Homo sapiens_hsa012120.43279537
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43115302
126Tryptophan metabolism_Homo sapiens_hsa003800.41266556
127Ras signaling pathway_Homo sapiens_hsa040140.41156497
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.39470387
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39435055

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