CPLX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in visual perception (GO:0050908)9.97132691
2detection of light stimulus involved in sensory perception (GO:0050962)9.97132691
3retinal rod cell development (GO:0046548)8.37650740
4negative regulation of cytosolic calcium ion concentration (GO:0051481)7.63952087
5G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.36107118
6cellular potassium ion homeostasis (GO:0030007)6.34454515
7gamma-aminobutyric acid signaling pathway (GO:0007214)6.03865721
8response to pheromone (GO:0019236)5.91417895
9relaxation of smooth muscle (GO:0044557)5.81681067
10sodium ion export (GO:0071436)5.72624932
11protein localization to synapse (GO:0035418)5.67273369
12synaptic vesicle endocytosis (GO:0048488)5.66387985
13positive regulation of synapse maturation (GO:0090129)5.58524652
14rhodopsin mediated signaling pathway (GO:0016056)5.36094327
15potassium ion homeostasis (GO:0055075)5.32415305
16urinary tract smooth muscle contraction (GO:0014848)5.31892503
17retinal cone cell development (GO:0046549)5.31730230
18amino acid import (GO:0043090)5.19360512
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.07812847
20photoreceptor cell development (GO:0042461)5.07106093
21eye photoreceptor cell development (GO:0042462)4.92828610
22locomotory exploration behavior (GO:0035641)4.65422386
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.63809786
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.63332589
25regulation of rhodopsin mediated signaling pathway (GO:0022400)4.63168039
26regulation of synaptic vesicle exocytosis (GO:2000300)4.51678375
27innervation (GO:0060384)4.51440176
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44172764
29* synaptic vesicle exocytosis (GO:0016079)4.37903363
30regulation of synapse maturation (GO:0090128)4.30186106
31photoreceptor cell maintenance (GO:0045494)4.29246748
32mating behavior (GO:0007617)4.27223882
33regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.24818510
34regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13293143
35regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.12608835
36regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.12608835
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.11808661
38mitotic cell cycle arrest (GO:0071850)4.10244001
39regulation of neuronal synaptic plasticity (GO:0048168)4.07852717
40synaptic vesicle maturation (GO:0016188)4.01443826
41striatum development (GO:0021756)4.00157204
42regulation of voltage-gated calcium channel activity (GO:1901385)3.96196071
43neuronal action potential propagation (GO:0019227)3.94343171
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.92331510
45cell communication by electrical coupling (GO:0010644)3.90906823
46cerebellar granule cell differentiation (GO:0021707)3.89775104
47regulation of cell communication by electrical coupling (GO:0010649)3.89681102
48gamma-aminobutyric acid transport (GO:0015812)3.84790899
49neuronal ion channel clustering (GO:0045161)3.82795468
50cellular sodium ion homeostasis (GO:0006883)3.80181280
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.78465037
52regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.77290385
53neurotransmitter-gated ion channel clustering (GO:0072578)3.76367051
54regulation of long-term neuronal synaptic plasticity (GO:0048169)3.75344019
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.75201540
56visual perception (GO:0007601)3.72049354
57regulation of synaptic vesicle transport (GO:1902803)3.71475711
58sensory perception of light stimulus (GO:0050953)3.70203962
59exploration behavior (GO:0035640)3.69540064
60potassium ion import (GO:0010107)3.69396312
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64045242
62substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.61452648
63substrate-independent telencephalic tangential migration (GO:0021826)3.61452648
64glutamate secretion (GO:0014047)3.60012060
65calcium ion import (GO:0070509)3.58549718
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58364523
67detection of light stimulus (GO:0009583)3.56302686
68protein-chromophore linkage (GO:0018298)3.53901742
69regulation of glutamate receptor signaling pathway (GO:1900449)3.52485220
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.51838698
71neuromuscular process controlling balance (GO:0050885)3.50292610
72GMP metabolic process (GO:0046037)3.48830104
73membrane hyperpolarization (GO:0060081)3.48556718
74detection of visible light (GO:0009584)3.48056207
75cell communication involved in cardiac conduction (GO:0086065)3.47841758
76membrane depolarization during action potential (GO:0086010)3.47396403
77vocalization behavior (GO:0071625)3.47170553
78peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.47048472
79dendritic spine morphogenesis (GO:0060997)3.46485813
80response to histamine (GO:0034776)3.46407705
81behavioral response to cocaine (GO:0048148)3.46227314
82positive regulation of membrane potential (GO:0045838)3.44322573
83glutamate receptor signaling pathway (GO:0007215)3.44000966
84activation of protein kinase A activity (GO:0034199)3.41814952
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41558057
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.41219140
87synaptic transmission, glutamatergic (GO:0035249)3.38605822
88long term synaptic depression (GO:0060292)3.34896767
89regulation of membrane repolarization (GO:0060306)3.33978654
90glycolytic process (GO:0006096)3.31036813
91potassium ion export (GO:0071435)3.30332936
92regulation of neurotransmitter uptake (GO:0051580)3.30165338
93long-term memory (GO:0007616)3.29187456
94dendritic spine organization (GO:0097061)3.28165074
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26568392
96behavioral defense response (GO:0002209)3.25951663
97behavioral fear response (GO:0001662)3.25951663
98long-term synaptic potentiation (GO:0060291)3.25645201
99nonmotile primary cilium assembly (GO:0035058)3.25514491
100regulation of cardiac muscle cell contraction (GO:0086004)3.24220568
101neurotransmitter secretion (GO:0007269)3.24111995
102regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23370263
103regulation of neurotransmitter levels (GO:0001505)3.22553907
104regulation of synapse structural plasticity (GO:0051823)3.22185206
105* regulation of neurotransmitter secretion (GO:0046928)3.20347301
106detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.19952787
107detection of temperature stimulus involved in sensory perception (GO:0050961)3.19952787
108cerebellar Purkinje cell differentiation (GO:0021702)3.16934290
109axon ensheathment in central nervous system (GO:0032291)3.16562262
110central nervous system myelination (GO:0022010)3.16562262
111regulation of synaptic plasticity (GO:0048167)3.15982275
112iron coordination entity transport (GO:1901678)3.15555059
113neuron-neuron synaptic transmission (GO:0007270)3.15155231
114* synaptic vesicle transport (GO:0048489)3.14635103
115* establishment of synaptic vesicle localization (GO:0097480)3.14635103
116regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.13860815
117prepulse inhibition (GO:0060134)3.12754719
118L-amino acid import (GO:0043092)3.12687045
119positive regulation of gastrulation (GO:2000543)3.11035032
120detection of calcium ion (GO:0005513)3.10289484
121peristalsis (GO:0030432)3.06633603
122cardiac conduction (GO:0061337)3.06617473
123regulation of ARF protein signal transduction (GO:0032012)3.05324202
124potassium ion transmembrane transport (GO:0071805)3.04133566
125cellular potassium ion transport (GO:0071804)3.04133566
126neurotransmitter transport (GO:0006836)3.03920032
127regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.03900054
128neuromuscular synaptic transmission (GO:0007274)3.03647791
129synaptic transmission, dopaminergic (GO:0001963)3.03565061
130synapse assembly (GO:0007416)3.02478235
131regulation of postsynaptic membrane potential (GO:0060078)3.02279274
132regulation of vesicle fusion (GO:0031338)3.00010454
133retina development in camera-type eye (GO:0060041)2.98469683
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.97975912
135positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97966609
136layer formation in cerebral cortex (GO:0021819)2.97369324
137axon cargo transport (GO:0008088)2.97342571
138regulation of actin filament-based movement (GO:1903115)2.97187499
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.95764224
140regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.94781741
141behavioral response to ethanol (GO:0048149)2.94401228
142pyrimidine dimer repair (GO:0006290)2.93940886
143response to acidic pH (GO:0010447)2.92584969
144positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92338804
145membrane repolarization (GO:0086009)2.91613950
146lactate metabolic process (GO:0006089)2.89637649
147membrane depolarization (GO:0051899)2.87235634
148fear response (GO:0042596)2.86644725
149proline transport (GO:0015824)2.86529683
150* regulation of neurotransmitter transport (GO:0051588)2.85857804
151vesicle docking involved in exocytosis (GO:0006904)2.85716307
152regulation of relaxation of muscle (GO:1901077)2.84551717
153regulation of dendritic spine morphogenesis (GO:0061001)2.83116788
154positive regulation of dendritic spine development (GO:0060999)2.81618406
155regulation of respiratory system process (GO:0044065)2.79214943
156transmission of nerve impulse (GO:0019226)2.73579090
157multicellular organismal signaling (GO:0035637)2.72021168
158cardiac muscle contraction (GO:0060048)2.71083870
159neuron cell-cell adhesion (GO:0007158)2.69172460
160positive regulation of catecholamine secretion (GO:0033605)2.68225346
161protein retention in ER lumen (GO:0006621)2.67661684
162regulation of respiratory gaseous exchange (GO:0043576)2.66596136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.20596507
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.56379948
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28824140
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85707567
5REST_21632747_ChIP-Seq_MESCs_Mouse2.75102106
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72765500
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68294882
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61054881
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59434607
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58521364
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53901575
12DROSHA_22980978_ChIP-Seq_HELA_Human2.51019803
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48385867
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.43970094
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42021187
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39613902
17TAF15_26573619_Chip-Seq_HEK293_Human2.37689297
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.30745912
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26736418
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26012836
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22497230
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22497230
23AR_21572438_ChIP-Seq_LNCaP_Human2.20254769
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19585110
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19440988
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17329997
27EZH2_22144423_ChIP-Seq_EOC_Human2.13518395
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12929880
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.12921355
30VDR_22108803_ChIP-Seq_LS180_Human2.12515505
31P53_22127205_ChIP-Seq_FIBROBLAST_Human2.10986730
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.07264038
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05279328
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.00891412
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95565954
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91534248
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.91350643
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78067325
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.72347978
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71111410
41SMAD4_21799915_ChIP-Seq_A2780_Human1.68688785
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.67382640
43FUS_26573619_Chip-Seq_HEK293_Human1.65807116
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.63256462
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62765902
46IGF1R_20145208_ChIP-Seq_DFB_Human1.62224059
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58182786
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.58138510
49CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.54540530
50AR_25329375_ChIP-Seq_VCAP_Human1.52832063
51KDM2B_26808549_Chip-Seq_K562_Human1.51766743
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51708090
53P300_19829295_ChIP-Seq_ESCs_Human1.51567268
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.50319676
55RNF2_27304074_Chip-Seq_NSC_Mouse1.48967683
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48817361
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47307032
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.43214485
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40193420
60* CTCF_27219007_Chip-Seq_Bcells_Human1.39875220
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38437569
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38035870
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36466477
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36317242
65ZNF263_19887448_ChIP-Seq_K562_Human1.33870625
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.32816996
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32815380
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32367789
69AR_19668381_ChIP-Seq_PC3_Human1.32263932
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.30323449
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29403702
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28463692
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28001235
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.27968946
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27685666
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25134997
77TCF4_23295773_ChIP-Seq_U87_Human1.23284563
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23012877
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22859969
80STAT3_23295773_ChIP-Seq_U87_Human1.20712889
81* SMC4_20622854_ChIP-Seq_HELA_Human1.19636049
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.19548900
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.16436168
84ER_23166858_ChIP-Seq_MCF-7_Human1.16344553
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14611906
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13871772
87CREB1_26743006_Chip-Seq_LNCaP_Human1.13833833
88CBP_20019798_ChIP-Seq_JUKART_Human1.13326929
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13326929
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12554314
91GATA1_22025678_ChIP-Seq_K562_Human1.11453076
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.10346742
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.10208164
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.09307708
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09250368
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07421877
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05870582
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05800284
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04912086
100* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04355853
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.03377004
102NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.02790568
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02557642
104BP1_19119308_ChIP-ChIP_Hs578T_Human1.02212025
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02075561
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99488504
107SOX9_26525672_Chip-Seq_HEART_Mouse0.99258630
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98953726
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98272167
110LXR_22292898_ChIP-Seq_THP-1_Human0.96683985
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94232486
112* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94204629
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93919076
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93833212
115OCT4_19829295_ChIP-Seq_ESCs_Human0.93292187
116JUN_21703547_ChIP-Seq_K562_Human0.92982593
117KDM2B_26808549_Chip-Seq_DND41_Human0.92721000
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92259003
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92259003
120AHR_22903824_ChIP-Seq_MCF-7_Human0.91995212
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91525986
122EGR1_19032775_ChIP-ChIP_M12_Human0.91406774
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.90334624
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89741451
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.89665821
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.89464321
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89281666
128SMAD4_21741376_ChIP-Seq_EPCs_Human0.89160804
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87622145
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87556777
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.87500396
132CLOCK_20551151_ChIP-Seq_293T_Human0.87290105
133KDM2B_26808549_Chip-Seq_REH_Human0.86990303
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86558732
135BCAT_22108803_ChIP-Seq_LS180_Human0.86542826
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86335234
137TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86226317
138* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86093985
139TCF4_22108803_ChIP-Seq_LS180_Human0.85728832
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85560590
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83957795
142OCT1_27270436_Chip-Seq_PROSTATE_Human0.83585738
143TP63_17297297_ChIP-ChIP_HaCaT_Human0.81862528
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77151468
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75043002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog6.59566868
2MP0006072_abnormal_retinal_apoptosis4.78912758
3MP0001984_abnormal_olfaction4.31293933
4MP0005253_abnormal_eye_physiology3.62977851
5MP0003011_delayed_dark_adaptation3.51590417
6MP0001502_abnormal_circadian_rhythm3.01035137
7* MP0002090_abnormal_vision2.94492900
8MP0006292_abnormal_olfactory_placode2.92318375
9MP0003941_abnormal_skin_development2.78385718
10MP0004233_abnormal_muscle_weight2.65993688
11MP0003880_abnormal_central_pattern2.59850306
12* MP0005195_abnormal_posterior_eye2.56989229
13MP0003635_abnormal_synaptic_transmissio2.46535142
14MP0004859_abnormal_synaptic_plasticity2.38093303
15MP0009046_muscle_twitch2.36618037
16MP0003950_abnormal_plasma_membrane2.29132277
17MP0002638_abnormal_pupillary_reflex2.25293638
18MP0002734_abnormal_mechanical_nocicepti2.22974141
19MP0003646_muscle_fatigue2.20982478
20MP0002272_abnormal_nervous_system2.14237664
21MP0002064_seizures2.13783752
22MP0002063_abnormal_learning/memory/cond2.12344575
23MP0001968_abnormal_touch/_nociception2.11298185
24MP0001486_abnormal_startle_reflex2.05118967
25MP0001188_hyperpigmentation1.99546730
26MP0009745_abnormal_behavioral_response1.94590660
27MP0002229_neurodegeneration1.90102879
28MP0010386_abnormal_urinary_bladder1.82367843
29MP0002736_abnormal_nociception_after1.79801356
30MP0002067_abnormal_sensory_capabilities1.77701915
31MP0005394_taste/olfaction_phenotype1.76468078
32MP0005499_abnormal_olfactory_system1.76468078
33MP0002572_abnormal_emotion/affect_behav1.75591592
34MP0002735_abnormal_chemical_nociception1.70091460
35MP0001324_abnormal_eye_pigmentation1.68036380
36MP0004782_abnormal_surfactant_physiolog1.67692034
37MP0002184_abnormal_innervation1.67529070
38MP0005423_abnormal_somatic_nervous1.65169718
39MP0003315_abnormal_perineum_morphology1.62732980
40MP0004036_abnormal_muscle_relaxation1.61354322
41MP0005248_abnormal_Harderian_gland1.60695744
42MP0008004_abnormal_stomach_pH1.57686340
43MP0005391_vision/eye_phenotype1.56774854
44* MP0002752_abnormal_somatic_nervous1.56503277
45MP0008789_abnormal_olfactory_epithelium1.55428946
46MP0000516_abnormal_urinary_system1.52764525
47MP0005367_renal/urinary_system_phenotyp1.52764525
48MP0001346_abnormal_lacrimal_gland1.51477028
49MP0004084_abnormal_cardiac_muscle1.50720307
50MP0002733_abnormal_thermal_nociception1.49058150
51MP0004215_abnormal_myocardial_fiber1.47703550
52MP0003879_abnormal_hair_cell1.43482238
53* MP0002882_abnormal_neuron_morphology1.41599217
54MP0004270_analgesia1.40775882
55MP0008775_abnormal_heart_ventricle1.40753177
56MP0008569_lethality_at_weaning1.37443932
57MP0001529_abnormal_vocalization1.34792972
58MP0010030_abnormal_orbit_morphology1.32645143
59MP0003787_abnormal_imprinting1.31758851
60MP0004142_abnormal_muscle_tone1.30136217
61MP0001501_abnormal_sleep_pattern1.29102467
62MP0002234_abnormal_pharynx_morphology1.27021084
63MP0000631_abnormal_neuroendocrine_gland1.25718680
64MP0002653_abnormal_ependyma_morphology1.23221558
65MP0001905_abnormal_dopamine_level1.22422717
66MP0005167_abnormal_blood-brain_barrier1.19783179
67MP0004510_myositis1.19476370
68MP0002332_abnormal_exercise_endurance1.19429150
69MP0002009_preneoplasia1.16715824
70MP0004484_altered_response_of1.16128421
71MP0002909_abnormal_adrenal_gland1.13521533
72MP0001970_abnormal_pain_threshold1.12938706
73MP0008874_decreased_physiological_sensi1.12714403
74MP0000920_abnormal_myelination1.11394422
75MP0003183_abnormal_peptide_metabolism1.09399203
76MP0005595_abnormal_vascular_smooth1.08476562
77MP0002557_abnormal_social/conspecific_i1.03891633
78MP0005187_abnormal_penis_morphology1.01416212
79MP0002822_catalepsy1.00392158
80MP0001177_atelectasis0.99947489
81MP0000955_abnormal_spinal_cord0.99367518
82MP0004811_abnormal_neuron_physiology0.98838805
83MP0000749_muscle_degeneration0.96656224
84MP0005623_abnormal_meninges_morphology0.96168429
85MP0002837_dystrophic_cardiac_calcinosis0.95494351
86MP0000751_myopathy0.95019341
87MP0003690_abnormal_glial_cell0.91697901
88MP0001542_abnormal_bone_strength0.91255072
89MP0003634_abnormal_glial_cell0.90950780
90MP0005670_abnormal_white_adipose0.90199341
91MP0002066_abnormal_motor_capabilities/c0.87829191
92MP0004145_abnormal_muscle_electrophysio0.87304373
93MP0005535_abnormal_body_temperature0.86565217
94MP0001986_abnormal_taste_sensitivity0.86219877
95MP0004924_abnormal_behavior0.84967057
96MP0005386_behavior/neurological_phenoty0.84967057
97MP0004085_abnormal_heartbeat0.83723489
98MP0004087_abnormal_muscle_fiber0.81782802
99MP0000778_abnormal_nervous_system0.81656930
100MP0000537_abnormal_urethra_morphology0.80378563
101MP0006276_abnormal_autonomic_nervous0.79557339
102MP0003633_abnormal_nervous_system0.76540482
103MP0002972_abnormal_cardiac_muscle0.75164974
104MP0003632_abnormal_nervous_system0.73940675
105MP0003137_abnormal_impulse_conducting0.73318137
106MP0005330_cardiomyopathy0.73279237
107MP0000747_muscle_weakness0.73089541
108MP0001440_abnormal_grooming_behavior0.72311026
109MP0003123_paternal_imprinting0.72273832
110MP0001664_abnormal_digestion0.72104361
111MP0008872_abnormal_physiological_respon0.71904266
112MP0002069_abnormal_eating/drinking_beha0.71488727
113MP0009697_abnormal_copulation0.71387865
114MP0008260_abnormal_autophagy0.71104276
115MP0005410_abnormal_fertilization0.68832583
116MP0002152_abnormal_brain_morphology0.67897364
117MP0001963_abnormal_hearing_physiology0.66887233
118MP0005620_abnormal_muscle_contractility0.66443587
119MP0004043_abnormal_pH_regulation0.64623216
120MP0003045_fibrosis0.64166409
121MP0004885_abnormal_endolymph0.64140205
122MP0006138_congestive_heart_failure0.63277688
123MP0005646_abnormal_pituitary_gland0.62239836
124MP0003890_abnormal_embryonic-extraembry0.61432819
125MP0005385_cardiovascular_system_phenoty0.60079638
126MP0001544_abnormal_cardiovascular_syste0.60079638
127MP0004742_abnormal_vestibular_system0.59554534
128MP0008877_abnormal_DNA_methylation0.58846551
129MP0000534_abnormal_ureter_morphology0.57376636
130MP0003868_abnormal_feces_composition0.55339879
131MP0000013_abnormal_adipose_tissue0.54869411
132MP0003631_nervous_system_phenotype0.53035128
133MP0002751_abnormal_autonomic_nervous0.51873836
134MP0003329_amyloid_beta_deposits0.51198698

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.29960868
2Abnormal rod and cone electroretinograms (HP:0008323)7.36893234
3Abnormality of macular pigmentation (HP:0008002)7.13673912
4Severe visual impairment (HP:0001141)6.88211584
5Scotoma (HP:0000575)5.92522593
6Bony spicule pigmentary retinopathy (HP:0007737)5.89944782
7Decreased central vision (HP:0007663)5.60890416
8Ankle clonus (HP:0011448)4.88805369
9Epileptic encephalopathy (HP:0200134)4.87187339
10Keratoconus (HP:0000563)4.83438439
11Increased corneal curvature (HP:0100692)4.83438439
12Absent rod-and cone-mediated responses on ERG (HP:0007688)4.82501062
13Abnormal gallbladder physiology (HP:0012438)4.73165951
14Cholecystitis (HP:0001082)4.73165951
15Septo-optic dysplasia (HP:0100842)4.30981142
16Bundle branch block (HP:0011710)4.18483600
17Supranuclear gaze palsy (HP:0000605)4.09111084
18Febrile seizures (HP:0002373)3.98085901
19Hypercortisolism (HP:0001578)3.91413294
20Abolished electroretinogram (ERG) (HP:0000550)3.89574797
21Attenuation of retinal blood vessels (HP:0007843)3.87625283
22Pendular nystagmus (HP:0012043)3.81230778
23Spastic gait (HP:0002064)3.64448183
24Cerebral hypomyelination (HP:0006808)3.64395915
25Obstructive sleep apnea (HP:0002870)3.60366183
26Postural instability (HP:0002172)3.58531489
27Chorioretinal atrophy (HP:0000533)3.52839540
28Progressive cerebellar ataxia (HP:0002073)3.49898072
29Aplasia/Hypoplasia of the fovea (HP:0008060)3.48714259
30Hypoplasia of the fovea (HP:0007750)3.48714259
31Ventricular fibrillation (HP:0001663)3.47612745
32Absence seizures (HP:0002121)3.41506856
33Pigmentary retinal degeneration (HP:0001146)3.40684475
34Abnormal eating behavior (HP:0100738)3.37070409
35Myokymia (HP:0002411)3.36163208
36Lower limb muscle weakness (HP:0007340)3.31992633
37Hand muscle atrophy (HP:0009130)3.25422821
38Visual hallucinations (HP:0002367)3.24313012
39Papilledema (HP:0001085)3.18993466
40Neurofibrillary tangles (HP:0002185)3.08815496
41Photophobia (HP:0000613)3.07401319
42Type II diabetes mellitus (HP:0005978)3.03856882
43Torticollis (HP:0000473)3.00842141
44Dyschromatopsia (HP:0007641)2.97776714
45Abnormal pupillary function (HP:0007686)2.96066347
46Urinary urgency (HP:0000012)2.93893079
47Heart block (HP:0012722)2.91581297
48Focal motor seizures (HP:0011153)2.91247886
49Atrial fibrillation (HP:0005110)2.89467106
50Sudden death (HP:0001699)2.83932412
51Abnormality of the fovea (HP:0000493)2.83575926
52Dialeptic seizures (HP:0011146)2.82984870
53Constricted visual fields (HP:0001133)2.82819417
54Distal upper limb amyotrophy (HP:0007149)2.81865068
55Upper limb amyotrophy (HP:0009129)2.81865068
56Hyporeflexia of lower limbs (HP:0002600)2.81846999
57Fetal akinesia sequence (HP:0001989)2.80740894
58Syncope (HP:0001279)2.78906932
59Albinism (HP:0001022)2.78180957
60Sleep apnea (HP:0010535)2.75878886
61Primary atrial arrhythmia (HP:0001692)2.72605242
62Abnormal EKG (HP:0003115)2.70929596
63Annular pancreas (HP:0001734)2.69301759
64Abnormal atrioventricular conduction (HP:0005150)2.69228383
65Limb dystonia (HP:0002451)2.68664534
66Cone-rod dystrophy (HP:0000548)2.68269759
67Gait imbalance (HP:0002141)2.67779585
68Neuronal loss in central nervous system (HP:0002529)2.66743346
69Clonus (HP:0002169)2.66267181
70Foot dorsiflexor weakness (HP:0009027)2.65692507
71Retinitis pigmentosa (HP:0000510)2.65594548
72Delusions (HP:0000746)2.64661679
73Hemiparesis (HP:0001269)2.63182479
74Urinary bladder sphincter dysfunction (HP:0002839)2.61895781
75Hyperparathyroidism (HP:0000843)2.61877871
76Supraventricular tachycardia (HP:0004755)2.60391482
77Congenital primary aphakia (HP:0007707)2.56472376
78Peripheral hypomyelination (HP:0007182)2.55501353
79Dysdiadochokinesis (HP:0002075)2.53036188
80Supraventricular arrhythmia (HP:0005115)2.52010200
81Impaired vibration sensation in the lower limbs (HP:0002166)2.50275603
82Bradykinesia (HP:0002067)2.49138939
83Congenital sensorineural hearing impairment (HP:0008527)2.47786665
84Abnormality of the foot musculature (HP:0001436)2.47462042
85Adrenal overactivity (HP:0002717)2.46975926
86Generalized tonic-clonic seizures (HP:0002069)2.44629015
87Resting tremor (HP:0002322)2.42532850
88Aplasia/Hypoplasia of the macula (HP:0008059)2.41461741
89Macular degeneration (HP:0000608)2.39806788
90Medial flaring of the eyebrow (HP:0010747)2.38991218
91Impaired smooth pursuit (HP:0007772)2.37804934
92Posterior subcapsular cataract (HP:0007787)2.34222426
93Nephrogenic diabetes insipidus (HP:0009806)2.33854113
94Rapidly progressive (HP:0003678)2.32310134
95Atrioventricular block (HP:0001678)2.31997873
96Optic nerve hypoplasia (HP:0000609)2.30295603
97EEG with generalized epileptiform discharges (HP:0011198)2.30142828
98Aplasia/Hypoplasia affecting the retina (HP:0008061)2.29056238
99Epileptiform EEG discharges (HP:0011182)2.28465127
100Hammertoe (HP:0001765)2.26303527
101Focal dystonia (HP:0004373)2.23728167
102Tetraplegia (HP:0002445)2.23726248
103Lower limb amyotrophy (HP:0007210)2.23660333
104Poor eye contact (HP:0000817)2.22434847
105Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.19724531
106Hemiplegia (HP:0002301)2.18677527
107Optic disc pallor (HP:0000543)2.18183747
108Cerebral inclusion bodies (HP:0100314)2.16339803
109Craniofacial dystonia (HP:0012179)2.15010919
110Prolonged QT interval (HP:0001657)2.14756999
111Dysmetric saccades (HP:0000641)2.11472646
112Status epilepticus (HP:0002133)2.11357389
113Atonic seizures (HP:0010819)2.09755585
114Generalized hypopigmentation (HP:0007513)2.09641659
115Focal seizures (HP:0007359)2.08970464
116Stereotypic behavior (HP:0000733)2.08187948
117Choroideremia (HP:0001139)2.07866034
118Broad-based gait (HP:0002136)2.07505968
119Depression (HP:0000716)2.07117571
120Emotional lability (HP:0000712)2.03798138
121Retinal dysplasia (HP:0007973)2.00578492
122Mutism (HP:0002300)2.00489854
123Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00437644
124Congenital stationary night blindness (HP:0007642)14.0004054
125Insomnia (HP:0100785)1.99710933
126Rigidity (HP:0002063)1.99116867
127Apathy (HP:0000741)1.99071465
128Upper limb muscle weakness (HP:0003484)1.98875116
129CNS hypomyelination (HP:0003429)1.98204811
130Impaired vibratory sensation (HP:0002495)1.97826168
131Absent septum pellucidum (HP:0001331)1.97183764
132Intention tremor (HP:0002080)1.96806667
133Abnormality of ocular smooth pursuit (HP:0000617)1.96105204
134Muscle fiber splitting (HP:0003555)1.95418046
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94608148
136Poor coordination (HP:0002370)1.93568899
137Unsteady gait (HP:0002317)1.92325826
138Akinesia (HP:0002304)1.91440052
139Steppage gait (HP:0003376)1.91145650
140Calf muscle hypertrophy (HP:0008981)1.90727690
141Abnormality of the corticospinal tract (HP:0002492)1.90119227
142Diminished motivation (HP:0000745)1.89665066
143Abnormality of abdominal situs (HP:0011620)1.88073239
144Abdominal situs inversus (HP:0003363)1.88073239
145EMG: myopathic abnormalities (HP:0003458)1.87122401
146Exercise-induced myalgia (HP:0003738)1.86676884
147Severe Myopia (HP:0011003)1.86178856
148Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78242690
149Growth hormone deficiency (HP:0000824)1.77050203
150Astigmatism (HP:0000483)1.76504271
151Chorioretinal coloboma (HP:0000567)1.71590854
152Vaginal atresia (HP:0000148)1.69706960
153Genital tract atresia (HP:0001827)1.66672765
154Neoplasm of the heart (HP:0100544)1.66016364
155Aplasia/Hypoplasia of the lens (HP:0008063)1.65463996
156Abnormal hair whorl (HP:0010721)1.65395216
157Action tremor (HP:0002345)1.65185533
158Abnormality of the septum pellucidum (HP:0007375)1.63961510
159Abnormality of binocular vision (HP:0011514)1.61414346
160Diplopia (HP:0000651)1.61414346
161Polyphagia (HP:0002591)1.59973370
162Progressive visual loss (HP:0000529)1.59478030
163Truncal ataxia (HP:0002078)1.58367543
164Hypsarrhythmia (HP:0002521)1.57604409
165Gaze-evoked nystagmus (HP:0000640)1.56378453
166Abnormality of the lower motor neuron (HP:0002366)1.56300039
167Cholelithiasis (HP:0001081)1.56277706
168Anxiety (HP:0000739)1.55080999
169Dysmetria (HP:0001310)1.54721479
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.52570622
171Subcapsular cataract (HP:0000523)1.51367869
172Abnormality of alanine metabolism (HP:0010916)1.50515902
173Hyperalaninemia (HP:0003348)1.50515902
174Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.50515902
175Vitreoretinal degeneration (HP:0000655)1.49796463
176Incomplete penetrance (HP:0003829)1.49377608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM26.43010699
2NME14.35360904
3PRPF4B4.18365768
4MAP3K43.63935508
5PAK63.10399025
6NEK13.10353942
7MAP2K72.70404194
8DYRK1A2.55977058
9DAPK32.54865359
10CASK2.54423794
11TAOK22.22231501
12TRIM282.16359152
13MINK12.15219847
14MAP3K52.10386694
15MYLK2.05631648
16RIPK12.02059857
17PINK11.94178343
18UHMK11.93293854
19STK381.91594726
20PHKG11.90872579
21PHKG21.90872579
22CDK31.84285831
23MARK11.82252955
24GRK11.79399517
25PBK1.78360499
26BCR1.69846577
27STK38L1.65486936
28CDK61.64556827
29AKT31.64191043
30CDK191.62757858
31INSRR1.60743065
32EPHA41.46602168
33LATS21.44622823
34DAPK21.41130115
35MAP2K41.40390721
36MAP3K91.38162940
37GRK51.35143404
38MAP3K131.33914577
39SGK2231.28968433
40SGK4941.28968433
41FES1.28833359
42CDK81.28735292
43MAP3K71.21887156
44TNK21.21104089
45CDK141.20977811
46CAMK2D1.17518563
47TNIK1.16301404
48PRKCG1.14111078
49CDK151.12134436
50PLK21.11489345
51CDK181.09247020
52SIK21.05389420
53TSSK61.03689888
54CDK51.03211453
55MAP3K61.02552295
56ARAF1.01406115
57CDK11A0.99722528
58MAPK130.97222763
59NTRK30.94854604
60CAMK2A0.93355130
61CLK10.91675719
62OXSR10.89512221
63DAPK10.89162830
64FER0.87755240
65IRAK20.82806896
66MAPK70.82248763
67ADRBK10.81326182
68TESK10.79929604
69MAPK40.78483154
70PIM10.77865200
71NTRK20.75107357
72PRKAA10.75022537
73PRKCE0.74885060
74CAMK10.74722159
75PAK30.73325085
76PTK2B0.72603835
77PLK30.71805051
78SGK30.71580932
79PAK20.68672225
80PRKCH0.67266208
81NTRK10.66617344
82PKN10.66359552
83MAP3K120.66056843
84PRKD30.63452499
85BRAF0.62945004
86CSNK1A1L0.62721288
87ADRBK20.62162422
88CAMKK20.61655101
89PRKG10.60866853
90MAPK100.60067904
91CAMK2G0.59481353
92IRAK10.58808544
93NEK60.57806217
94SGK10.57020813
95MARK20.54398911
96MAP2K60.53926568
97PRKCA0.53528183
98WNK30.51303914
99PRKCZ0.51035372
100CAMK1D0.50660763
101PRKACA0.50014383
102ROCK20.49572939
103KSR20.49384888
104BMPR20.49320842
105PRKCB0.49184370
106CAMKK10.48170156
107PRKD20.48135129
108SIK30.48112199
109CSNK1G20.47677322
110EIF2AK30.47546705
111TYRO30.46367071
112PRKACB0.46132290
113MARK30.45239303
114STK110.44953320
115RPS6KA30.44831952
116OBSCN0.44095628
117WNK10.43180563
118TTN0.42280409
119CCNB10.41060433
120STK160.40019238
121EPHA30.39595411
122BRD40.39445331
123MAPK90.39072163
124GSK3B0.38978789
125DYRK1B0.38340521
126SGK20.38270321
127RIPK40.37907195
128CAMK40.37551956
129PDK10.37539809
130LIMK10.37484902
131MAPK80.37424422
132EIF2AK10.36229084
133CAMK2B0.35034738
134KSR10.33770449
135PDPK10.32274681
136EEF2K0.31776500
137MAPK120.31232250
138RPS6KB10.30356905
139ICK0.30202154
140BRSK10.28680360
141CSNK1G30.28064922
142LMTK20.28045314
143DMPK0.27725246
144RPS6KA50.26815883
145ALK0.26567914

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.52115346
2Nicotine addiction_Homo sapiens_hsa050334.49072866
3GABAergic synapse_Homo sapiens_hsa047274.07599842
4* Synaptic vesicle cycle_Homo sapiens_hsa047213.72261404
5Morphine addiction_Homo sapiens_hsa050323.67312883
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.56917397
7Circadian entrainment_Homo sapiens_hsa047132.76235984
8Olfactory transduction_Homo sapiens_hsa047402.50538122
9Collecting duct acid secretion_Homo sapiens_hsa049662.35685919
10Insulin secretion_Homo sapiens_hsa049112.14435741
11Circadian rhythm_Homo sapiens_hsa047102.12703427
12Glutamatergic synapse_Homo sapiens_hsa047242.03968841
13Fructose and mannose metabolism_Homo sapiens_hsa000511.94811456
14Renin secretion_Homo sapiens_hsa049241.90442924
15Salivary secretion_Homo sapiens_hsa049701.88587948
16Cholinergic synapse_Homo sapiens_hsa047251.88321350
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84624085
18Serotonergic synapse_Homo sapiens_hsa047261.75516807
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70434155
20Taste transduction_Homo sapiens_hsa047421.69996330
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65690985
22Dopaminergic synapse_Homo sapiens_hsa047281.64362075
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55478608
24Cardiac muscle contraction_Homo sapiens_hsa042601.49859383
25Oxytocin signaling pathway_Homo sapiens_hsa049211.47350355
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44028373
27Glioma_Homo sapiens_hsa052141.42817065
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40937033
29Calcium signaling pathway_Homo sapiens_hsa040201.24575202
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23527844
31Vibrio cholerae infection_Homo sapiens_hsa051101.23216714
32Biosynthesis of amino acids_Homo sapiens_hsa012301.22440157
33Dilated cardiomyopathy_Homo sapiens_hsa054141.17024828
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16688494
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14964622
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10645868
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07703135
38Gap junction_Homo sapiens_hsa045401.04845872
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04696802
40ErbB signaling pathway_Homo sapiens_hsa040121.02508911
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.01196120
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99343812
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95238272
44Gastric acid secretion_Homo sapiens_hsa049710.90576622
45Amphetamine addiction_Homo sapiens_hsa050310.84665973
46Long-term potentiation_Homo sapiens_hsa047200.83902769
47cAMP signaling pathway_Homo sapiens_hsa040240.83018663
48Type II diabetes mellitus_Homo sapiens_hsa049300.81690526
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81640455
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.79044529
51GnRH signaling pathway_Homo sapiens_hsa049120.77905543
52Long-term depression_Homo sapiens_hsa047300.76988686
53AMPK signaling pathway_Homo sapiens_hsa041520.76723050
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73847377
55beta-Alanine metabolism_Homo sapiens_hsa004100.72642685
56Histidine metabolism_Homo sapiens_hsa003400.72291374
57Arginine biosynthesis_Homo sapiens_hsa002200.72194525
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72108588
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71694698
60Arginine and proline metabolism_Homo sapiens_hsa003300.67382975
61Rheumatoid arthritis_Homo sapiens_hsa053230.65343481
62Galactose metabolism_Homo sapiens_hsa000520.64143838
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63633896
64Mineral absorption_Homo sapiens_hsa049780.63375859
65Pentose phosphate pathway_Homo sapiens_hsa000300.62682853
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62492201
67Carbon metabolism_Homo sapiens_hsa012000.61666588
68Inositol phosphate metabolism_Homo sapiens_hsa005620.60779263
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60664282
70Endocytosis_Homo sapiens_hsa041440.59931372
71Pancreatic secretion_Homo sapiens_hsa049720.59511594
72Regulation of autophagy_Homo sapiens_hsa041400.58738506
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58581453
74Cocaine addiction_Homo sapiens_hsa050300.56609058
75Insulin signaling pathway_Homo sapiens_hsa049100.55124735
76Alcoholism_Homo sapiens_hsa050340.53952253
77Prostate cancer_Homo sapiens_hsa052150.52591239
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52550312
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52494426
80Bile secretion_Homo sapiens_hsa049760.50299467
81Pyruvate metabolism_Homo sapiens_hsa006200.49996977
82Prion diseases_Homo sapiens_hsa050200.49667397
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.49443818
84Thyroid hormone synthesis_Homo sapiens_hsa049180.46126700
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44855926
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44746577
87Oxidative phosphorylation_Homo sapiens_hsa001900.44707952
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44533900
89Ovarian steroidogenesis_Homo sapiens_hsa049130.43630050
90Butanoate metabolism_Homo sapiens_hsa006500.43570834
91Dorso-ventral axis formation_Homo sapiens_hsa043200.42235235
92FoxO signaling pathway_Homo sapiens_hsa040680.41474953
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.41359096
94Propanoate metabolism_Homo sapiens_hsa006400.39867531
95mTOR signaling pathway_Homo sapiens_hsa041500.38670021
96Fatty acid biosynthesis_Homo sapiens_hsa000610.37671781
97Estrogen signaling pathway_Homo sapiens_hsa049150.37124043
98Bladder cancer_Homo sapiens_hsa052190.34867613
99MAPK signaling pathway_Homo sapiens_hsa040100.34810935
100HIF-1 signaling pathway_Homo sapiens_hsa040660.33315416
101Glucagon signaling pathway_Homo sapiens_hsa049220.32835058
102Purine metabolism_Homo sapiens_hsa002300.32057488
103Rap1 signaling pathway_Homo sapiens_hsa040150.32054808
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31771163
105Ras signaling pathway_Homo sapiens_hsa040140.31486811
106VEGF signaling pathway_Homo sapiens_hsa043700.30793041
107Alzheimers disease_Homo sapiens_hsa050100.27583008
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27298046
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.24383122
110Phagosome_Homo sapiens_hsa041450.23631694
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21550085
112Melanoma_Homo sapiens_hsa052180.20897551
113Renal cell carcinoma_Homo sapiens_hsa052110.17727947
114ABC transporters_Homo sapiens_hsa020100.17369730
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16503059
116Sphingolipid metabolism_Homo sapiens_hsa006000.16383222
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16231513
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.15999870
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15465990
120Phenylalanine metabolism_Homo sapiens_hsa003600.14852727
121Melanogenesis_Homo sapiens_hsa049160.13855701
122Choline metabolism in cancer_Homo sapiens_hsa052310.13653378
123Axon guidance_Homo sapiens_hsa043600.13048990
124Oocyte meiosis_Homo sapiens_hsa041140.12440988

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