CPM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.83995480
2axon ensheathment in central nervous system (GO:0032291)9.83995480
3fatty acid elongation (GO:0030497)7.60302699
4surfactant homeostasis (GO:0043129)6.09431003
5myelin maintenance (GO:0043217)5.86653956
6ensheathment of neurons (GO:0007272)5.56801037
7axon ensheathment (GO:0008366)5.56801037
8regulation of memory T cell differentiation (GO:0043380)5.54314313
9myelination (GO:0042552)5.51841386
10long-chain fatty acid biosynthetic process (GO:0042759)5.07495837
11adhesion of symbiont to host cell (GO:0044650)4.93711689
12virion attachment to host cell (GO:0019062)4.93711689
13chemical homeostasis within a tissue (GO:0048875)4.76732947
14positive regulation of vasculogenesis (GO:2001214)4.31790523
15photoreceptor cell differentiation (GO:0046530)4.29802948
16eye photoreceptor cell differentiation (GO:0001754)4.29802948
17negative regulation of multicellular organism growth (GO:0040015)4.23745683
18apical protein localization (GO:0045176)4.22313709
19asymmetric protein localization (GO:0008105)4.19033100
20amyloid precursor protein metabolic process (GO:0042982)4.16930468
21long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.08563433
22indole-containing compound catabolic process (GO:0042436)4.08092138
23indolalkylamine catabolic process (GO:0046218)4.08092138
24tryptophan catabolic process (GO:0006569)4.08092138
25oligodendrocyte differentiation (GO:0048709)4.07369857
26negative regulation of neurotransmitter secretion (GO:0046929)4.06893657
27cholesterol biosynthetic process (GO:0006695)4.06844456
28cellular response to cadmium ion (GO:0071276)3.87095927
29adhesion of symbiont to host (GO:0044406)3.79593833
30molting cycle (GO:0042303)3.77733880
31hair cycle (GO:0042633)3.77733880
32regulation of MHC class I biosynthetic process (GO:0045343)3.77602934
33kynurenine metabolic process (GO:0070189)3.75371146
34negative regulation of protein localization to cell surface (GO:2000009)3.74505295
35regulation of vasculogenesis (GO:2001212)3.69800137
36long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.69193405
37response to lipoprotein particle (GO:0055094)3.68971482
38cellular response to zinc ion (GO:0071294)3.67006478
39sterol catabolic process (GO:0016127)3.64231012
40cholesterol catabolic process (GO:0006707)3.64231012
41negative regulation of neurotransmitter transport (GO:0051589)3.60790960
42regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.57074178
43sterol biosynthetic process (GO:0016126)3.54436566
44negative regulation of type 2 immune response (GO:0002829)3.54300661
45regulation of sequestering of triglyceride (GO:0010889)3.53207134
46regulation of metalloenzyme activity (GO:0048552)3.51660318
47lateral sprouting from an epithelium (GO:0060601)3.51614292
48amyloid precursor protein catabolic process (GO:0042987)3.51284099
49positive regulation of lipid storage (GO:0010884)3.50912517
50limb bud formation (GO:0060174)3.47794152
51positive regulation of heat generation (GO:0031652)3.46427720
52lung lobe morphogenesis (GO:0060463)3.45346194
53protein localization to endosome (GO:0036010)3.43955671
54fatty-acyl-CoA biosynthetic process (GO:0046949)3.43724664
55tryptophan metabolic process (GO:0006568)3.39419828
56regulation of cholesterol storage (GO:0010885)3.37132717
57regulation of establishment of cell polarity (GO:2000114)3.33359675
58iron ion import (GO:0097286)3.31934860
59positive regulation of triglyceride biosynthetic process (GO:0010867)3.27224436
60pattern specification involved in kidney development (GO:0061004)3.25631362
61positive regulation of oligodendrocyte differentiation (GO:0048714)3.22203982
62calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.20730091
63regulation of integrin-mediated signaling pathway (GO:2001044)3.20156719
64creatine metabolic process (GO:0006600)3.19878699
65negative regulation of endothelial cell apoptotic process (GO:2000352)3.18972092
66bile acid biosynthetic process (GO:0006699)3.12987848
67fatty-acyl-CoA metabolic process (GO:0035337)3.12709466
68regulation of somitogenesis (GO:0014807)3.12641847
69cytoplasmic mRNA processing body assembly (GO:0033962)3.11264035
70mesodermal cell differentiation (GO:0048333)3.09661545
71prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.08758345
72negative regulation of complement activation (GO:0045916)3.07547787
73response to redox state (GO:0051775)3.05277151
74regulation of lipoprotein metabolic process (GO:0050746)3.04608427
75regulation of collateral sprouting (GO:0048670)3.04570982
76glycerophospholipid catabolic process (GO:0046475)3.03850439
77regulation of triglyceride catabolic process (GO:0010896)3.00856325
78peptidyl-tyrosine autophosphorylation (GO:0038083)2.99061449
79regulation of triglyceride biosynthetic process (GO:0010866)2.98772559
80regulation of interleukin-13 production (GO:0032656)2.98073778
81regulation of establishment or maintenance of cell polarity (GO:0032878)2.96645232
82very long-chain fatty acid metabolic process (GO:0000038)2.95516962
83import into cell (GO:0098657)2.95055951
84regulation of heat generation (GO:0031650)2.93527950
85negative regulation of mast cell activation (GO:0033004)2.92574729
86response to methylmercury (GO:0051597)2.92275259
87positive regulation of pseudopodium assembly (GO:0031274)2.87991988
88protein palmitoylation (GO:0018345)2.83359534
89keratan sulfate catabolic process (GO:0042340)2.82354565
90isoprenoid biosynthetic process (GO:0008299)2.81844530
91membrane tubulation (GO:0097320)2.81370830
92cellular biogenic amine catabolic process (GO:0042402)2.79248067
93amine catabolic process (GO:0009310)2.79248067
94branch elongation of an epithelium (GO:0060602)2.79117749
95negative regulation of protein activation cascade (GO:2000258)2.76482257
96magnesium ion transport (GO:0015693)2.75936057
97regulation of membrane protein ectodomain proteolysis (GO:0051043)2.75514165
98L-serine transport (GO:0015825)2.75474655
99membrane protein ectodomain proteolysis (GO:0006509)2.75421681
100indolalkylamine metabolic process (GO:0006586)2.74457055
101GPI anchor biosynthetic process (GO:0006506)2.73671691
102membrane raft organization (GO:0031579)2.73520707
103regulation of apoptotic process involved in morphogenesis (GO:1902337)2.71803467
104aromatic amino acid family catabolic process (GO:0009074)2.71238610
105L-amino acid import (GO:0043092)2.71053008
106regulation of lipid storage (GO:0010883)2.70974028
107sphingosine metabolic process (GO:0006670)2.70919887
108oligosaccharide catabolic process (GO:0009313)2.68121091
109organ growth (GO:0035265)2.67758595
110negative regulation of receptor-mediated endocytosis (GO:0048261)2.66957897
111peripheral nervous system axon ensheathment (GO:0032292)2.66933839
112myelination in peripheral nervous system (GO:0022011)2.66933839
113lipid storage (GO:0019915)2.66782042
114acyl-CoA biosynthetic process (GO:0071616)2.66671750
115thioester biosynthetic process (GO:0035384)2.66671750
116sodium-independent organic anion transport (GO:0043252)2.65564296
117low-density lipoprotein particle clearance (GO:0034383)2.64772994
118positive regulation of actin filament depolymerization (GO:0030836)2.64142990
119astrocyte development (GO:0014002)2.62585007
120negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.62293135
121positive regulation of triglyceride metabolic process (GO:0090208)2.62086659
122enteric nervous system development (GO:0048484)2.61083288
123branching involved in labyrinthine layer morphogenesis (GO:0060670)2.60242019
124negative regulation of lipase activity (GO:0060192)2.58775676
125GPI anchor metabolic process (GO:0006505)2.58685092
126negative regulation of JUN kinase activity (GO:0043508)2.58580685
127positive regulation of protein kinase C signaling (GO:0090037)2.58350960
128regulation of pseudopodium assembly (GO:0031272)2.57615691
129positive regulation of gliogenesis (GO:0014015)2.55414797
130negative regulation of macrophage differentiation (GO:0045650)2.55141186
131tight junction assembly (GO:0070830)2.54520434
132negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.53643040
133prostate gland growth (GO:0060736)2.52311358
134negative regulation of protein autophosphorylation (GO:0031953)2.51403737
135regulation of osteoblast proliferation (GO:0033688)2.51272816
136sex differentiation (GO:0007548)2.51213139
137phosphatidylserine metabolic process (GO:0006658)2.50247211
138nerve growth factor signaling pathway (GO:0038180)2.49830257
139nucleotide transmembrane transport (GO:1901679)2.48696214
140Leydig cell differentiation (GO:0033327)2.48377399
141cellular response to ATP (GO:0071318)2.48312912
142regulation of phospholipid biosynthetic process (GO:0071071)2.47244185
143regulation of mononuclear cell migration (GO:0071675)2.46961878
144positive regulation of fatty acid beta-oxidation (GO:0032000)2.45821498
145mesenchymal cell proliferation (GO:0010463)2.45099991
146keratinization (GO:0031424)2.44220331
147positive regulation of glial cell differentiation (GO:0045687)2.43773342
148neuron remodeling (GO:0016322)2.43157456
149phagocytosis, recognition (GO:0006910)2.43029407
150androgen biosynthetic process (GO:0006702)2.42910324
151cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.42627088
152phosphatidylserine acyl-chain remodeling (GO:0036150)2.42559887
153establishment of mitochondrion localization (GO:0051654)2.41863002
154interleukin-6-mediated signaling pathway (GO:0070102)2.41500837
155regulation of endothelial cell apoptotic process (GO:2000351)2.41155399
156diol metabolic process (GO:0034311)2.40604348
157negative regulation of lipid storage (GO:0010888)2.38937509
158lipid particle organization (GO:0034389)2.38900798
159bile acid metabolic process (GO:0008206)2.38266575
160serine transport (GO:0032329)2.38231513
161lens fiber cell development (GO:0070307)2.37686269
162substantia nigra development (GO:0021762)2.37221810
163ER overload response (GO:0006983)2.37185239
164cranial suture morphogenesis (GO:0060363)2.36117446
165regulation of macrophage derived foam cell differentiation (GO:0010743)2.33074175
166sphingoid metabolic process (GO:0046519)2.32505830
167negative regulation of endothelial cell proliferation (GO:0001937)2.32169764
168positive regulation of fatty acid oxidation (GO:0046321)2.30160601
169benzene-containing compound metabolic process (GO:0042537)2.30134129
170negative regulation of humoral immune response (GO:0002921)2.30059933
171estrogen biosynthetic process (GO:0006703)2.28542693
172regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.28042189
173steroid catabolic process (GO:0006706)2.28034765
174phospholipid translocation (GO:0045332)2.27652335
175lipid translocation (GO:0034204)2.27652335
176ADP metabolic process (GO:0046031)2.27599263
177one-carbon compound transport (GO:0019755)2.27010142
178UDP-N-acetylglucosamine metabolic process (GO:0006047)2.26622646
179plasma lipoprotein particle clearance (GO:0034381)2.26064435
180endocrine hormone secretion (GO:0060986)2.25231755
181triglyceride homeostasis (GO:0070328)2.24320397
182acylglycerol homeostasis (GO:0055090)2.24320397
183cellular response to thyroid hormone stimulus (GO:0097067)2.23840060
184negative regulation of nitric oxide biosynthetic process (GO:0045019)2.22371527
185lung vasculature development (GO:0060426)2.21817913
186androgen metabolic process (GO:0008209)2.19926040
187regulation of triglyceride metabolic process (GO:0090207)2.18303894
188regulation of transforming growth factor beta2 production (GO:0032909)2.17341929
189complement activation, alternative pathway (GO:0006957)2.14653824
190glycolipid catabolic process (GO:0019377)2.13600132
191ceramide catabolic process (GO:0046514)2.12379449
192amino sugar catabolic process (GO:0046348)2.12074317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77078874
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.61065625
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.59927547
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.52689004
5VDR_22108803_ChIP-Seq_LS180_Human2.23105261
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22628030
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22099863
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08106347
9SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05071344
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.03101454
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99833854
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.94851211
13IRF8_21731497_ChIP-ChIP_J774_Mouse1.93572401
14TP63_17297297_ChIP-ChIP_HaCaT_Human1.90296807
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89777415
16AHR_22903824_ChIP-Seq_MCF-7_Human1.87854379
17* LXR_22158963_ChIP-Seq_LIVER_Mouse1.85976318
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85882874
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85016908
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84674036
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82165347
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80834611
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76339523
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75102313
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.74230851
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.71509952
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70557401
28BCAT_22108803_ChIP-Seq_LS180_Human1.70173705
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68056472
30AR_21572438_ChIP-Seq_LNCaP_Human1.66529464
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63790834
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.61941178
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59125020
34* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.58272603
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54653311
36SOX2_20726797_ChIP-Seq_SW620_Human1.54048678
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.53616187
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52921287
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50480270
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50480270
41* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.49709363
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.47777639
43* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47698678
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.45702587
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44874542
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.44759582
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43832205
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42957457
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40876637
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.39123092
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.36716702
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.36452181
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35653617
54* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35254785
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.34174055
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32454167
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31352367
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27633518
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27633518
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.27395928
61* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27063154
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26400114
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.26021752
64SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25855700
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25818899
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24667820
67TAF15_26573619_Chip-Seq_HEK293_Human1.24508498
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23559060
69* CDX2_22108803_ChIP-Seq_LS180_Human1.23006841
70AR_25329375_ChIP-Seq_VCAP_Human1.22633306
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22477285
72TP53_18474530_ChIP-ChIP_U2OS_Human1.21955508
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21934591
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20954850
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20435156
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20088168
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19840606
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19408203
79CJUN_26792858_Chip-Seq_BT549_Human1.18925828
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18297814
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.17169111
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15909835
83* TP63_23658742_ChIP-Seq_EP156T_Human1.15307921
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14593643
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13770684
86* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12759015
87FOXA1_25552417_ChIP-Seq_VCAP_Human1.12584280
88RXR_22108803_ChIP-Seq_LS180_Human1.11979294
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11617316
90GATA4_25053715_ChIP-Seq_YYC3_Human1.11442958
91P300_19829295_ChIP-Seq_ESCs_Human1.11290791
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10536070
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.10444924
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09839592
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.09628114
96* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09127192
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08941221
98GBX2_23144817_ChIP-Seq_PC3_Human1.08639318
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08446901
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08327318
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08155721
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.07970504
103KLF5_25053715_ChIP-Seq_YYC3_Human1.07713674
104ZNF274_21170338_ChIP-Seq_K562_Hela1.06905722
105STAT3_23295773_ChIP-Seq_U87_Human1.06702324
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06468066
107TCF4_22108803_ChIP-Seq_LS180_Human1.05469347
108* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04846385
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04531632
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04103919
111* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03945773
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.03463279
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03357966
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.02738089
115SMAD4_21799915_ChIP-Seq_A2780_Human1.02212293
116TP53_16413492_ChIP-PET_HCT116_Human1.01775833
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00719303
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.00007792
119RUNX_20019798_ChIP-Seq_JUKART_Human0.99484539
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.98959797
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98094096
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97806400
123ER_23166858_ChIP-Seq_MCF-7_Human0.97406443
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.96161426
125* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95426299
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95293523
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.94069856
128* CRX_20693478_ChIP-Seq_RETINA_Mouse0.93826057
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93571933
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92692241
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92466734
132* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92453744
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92212714
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92122722
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90592194
136* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90226855
137VDR_24787735_ChIP-Seq_THP-1_Human0.89847580
138NANOG_19829295_ChIP-Seq_ESCs_Human0.89800908
139SOX2_19829295_ChIP-Seq_ESCs_Human0.89800908
140* TCF4_23295773_ChIP-Seq_U87_Human0.89661159
141SMRT_27268052_Chip-Seq_Bcells_Human0.89399425
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87379430
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86890554
144SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86571866
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86316711
146* ISL1_27105846_Chip-Seq_CPCs_Mouse0.85960222
147* BRD4_25478319_ChIP-Seq_HGPS_Human0.85923613
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85846925
149JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85353630
150KDM2B_26808549_Chip-Seq_REH_Human0.84898437
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84659818
152OCT1_27270436_Chip-Seq_PROSTATE_Human0.84596104
153SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83912407
154SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83912407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.61669978
2MP0004782_abnormal_surfactant_physiolog4.36841472
3MP0000920_abnormal_myelination4.31613727
4MP0010678_abnormal_skin_adnexa3.81984221
5MP0003950_abnormal_plasma_membrane3.79915615
6MP0000383_abnormal_hair_follicle3.54780007
7MP0000566_synostosis3.47223468
8MP0003195_calcinosis3.44640596
9MP0002098_abnormal_vibrissa_morphology2.85811255
10MP0000579_abnormal_nail_morphology2.72302416
11MP0004885_abnormal_endolymph2.59918758
12MP0002796_impaired_skin_barrier2.51584770
13MP0001958_emphysema2.51016927
14MP0000647_abnormal_sebaceous_gland2.50098097
15MP0002139_abnormal_hepatobiliary_system2.41133071
16MP0000537_abnormal_urethra_morphology2.36491444
17MP0003690_abnormal_glial_cell2.33035732
18MP0001346_abnormal_lacrimal_gland2.32890614
19MP0000569_abnormal_digit_pigmentation2.31094995
20MP0001177_atelectasis2.30198696
21MP0003252_abnormal_bile_duct2.29646788
22MP0002295_abnormal_pulmonary_circulatio2.27927911
23MP0004043_abnormal_pH_regulation2.21721243
24MP0010234_abnormal_vibrissa_follicle2.19024326
25MP0000462_abnormal_digestive_system2.15412089
26MP0000762_abnormal_tongue_morphology2.10331257
27MP0004742_abnormal_vestibular_system2.06872612
28MP0008875_abnormal_xenobiotic_pharmacok2.04201484
29MP0002876_abnormal_thyroid_physiology2.03328499
30MP0003329_amyloid_beta_deposits2.01740666
31MP0005670_abnormal_white_adipose1.99733897
32MP0005409_darkened_coat_color1.97298672
33MP0006082_CNS_inflammation1.96510597
34MP0002133_abnormal_respiratory_system1.91641512
35MP0005388_respiratory_system_phenotype1.91641512
36MP0005167_abnormal_blood-brain_barrier1.87220007
37MP0005647_abnormal_sex_gland1.84852619
38MP0003453_abnormal_keratinocyte_physiol1.80097161
39MP0005451_abnormal_body_composition1.78528013
40MP0001501_abnormal_sleep_pattern1.71536348
41MP0005365_abnormal_bile_salt1.68354071
42MP0004381_abnormal_hair_follicle1.67776588
43MP0005083_abnormal_biliary_tract1.67405838
44MP0002148_abnormal_hypersensitivity_rea1.66404847
45MP0005164_abnormal_response_to1.61859464
46MP0010329_abnormal_lipoprotein_level1.55709984
47MP0004130_abnormal_muscle_cell1.55055384
48MP0010386_abnormal_urinary_bladder1.54527627
49MP0000343_altered_response_to1.54496117
50MP0003634_abnormal_glial_cell1.53518979
51MP0001851_eye_inflammation1.53241806
52MP0001905_abnormal_dopamine_level1.48778388
53MP0000377_abnormal_hair_follicle1.47639497
54MP0004019_abnormal_vitamin_homeostasis1.42948721
55MP0005408_hypopigmentation1.42735901
56MP0005275_abnormal_skin_tensile1.41994462
57MP0005501_abnormal_skin_physiology1.41766270
58MP0008004_abnormal_stomach_pH1.41499389
59MP0002254_reproductive_system_inflammat1.40334322
60MP0003828_pulmonary_edema1.39235215
61MP0005171_absent_coat_pigmentation1.39167054
62MP0001986_abnormal_taste_sensitivity1.37854583
63MP0004272_abnormal_basement_membrane1.37776190
64MP0001485_abnormal_pinna_reflex1.36724382
65MP0003186_abnormal_redox_activity1.35881509
66MP0002118_abnormal_lipid_homeostasis1.35667526
67MP0003937_abnormal_limbs/digits/tail_de1.33261849
68MP0008995_early_reproductive_senescence1.32514975
69MP0003279_aneurysm1.32383371
70MP0005595_abnormal_vascular_smooth1.31427509
71MP0009785_altered_susceptibility_to1.31026667
72MP0003632_abnormal_nervous_system1.28888362
73MP0005334_abnormal_fat_pad1.28863967
74MP0002419_abnormal_innate_immunity1.27553975
75MP0001756_abnormal_urination1.27396746
76MP0002998_abnormal_bone_remodeling1.24718425
77MP0000685_abnormal_immune_system1.23564323
78MP0005058_abnormal_lysosome_morphology1.22815219
79MP0009764_decreased_sensitivity_to1.21361287
80MP0003172_abnormal_lysosome_physiology1.18507456
81MP0004134_abnormal_chest_morphology1.17065681
82MP0000778_abnormal_nervous_system1.16846703
83MP0003075_altered_response_to1.16599322
84MP0004883_abnormal_blood_vessel1.15980963
85MP0000371_diluted_coat_color1.14798147
86MP0004185_abnormal_adipocyte_glucose1.13020663
87MP0001533_abnormal_skeleton_physiology1.12889737
88MP0005085_abnormal_gallbladder_physiolo1.09996054
89MP0000467_abnormal_esophagus_morphology1.09668900
90MP0010368_abnormal_lymphatic_system1.09261630
91MP0000465_gastrointestinal_hemorrhage1.08700906
92MP0009384_cardiac_valve_regurgitation1.07925076
93MP0010771_integument_phenotype1.07587868
94MP0003136_yellow_coat_color1.07288184
95MP0000613_abnormal_salivary_gland1.06948215
96MP0003724_increased_susceptibility_to1.06302689
97MP0001216_abnormal_epidermal_layer1.06108779
98MP0005410_abnormal_fertilization1.05989930
99MP0010030_abnormal_orbit_morphology1.02866405
100MP0002229_neurodegeneration1.00832232
101MP0004947_skin_inflammation0.99944396
102MP0001661_extended_life_span0.97717728
103MP0005666_abnormal_adipose_tissue0.97544249
104MP0002282_abnormal_trachea_morphology0.97516700
105MP0003303_peritoneal_inflammation0.96859171
106MP0005023_abnormal_wound_healing0.95947159
107MP0000534_abnormal_ureter_morphology0.95039011
108MP0005375_adipose_tissue_phenotype0.94837420
109MP0005025_abnormal_response_to0.94753034
110MP0006054_spinal_hemorrhage0.94534814
111MP0000249_abnormal_blood_vessel0.94520609
112MP0005551_abnormal_eye_electrophysiolog0.91814371
113MP0000604_amyloidosis0.89672069
114MP0004264_abnormal_extraembryonic_tissu0.88572148
115MP0000681_abnormal_thyroid_gland0.88241130
116MP0001879_abnormal_lymphatic_vessel0.87511432
117MP0003283_abnormal_digestive_organ0.87410425
118MP0001340_abnormal_eyelid_morphology0.87380861
119MP0002971_abnormal_brown_adipose0.86525305
120MP0002060_abnormal_skin_morphology0.86303664
121MP0001299_abnormal_eye_distance/0.85527746
122MP0003436_decreased_susceptibility_to0.84381654
123MP0001845_abnormal_inflammatory_respons0.83830919
124MP0002233_abnormal_nose_morphology0.82599056
125MP0001853_heart_inflammation0.81983540
126MP0000427_abnormal_hair_cycle0.81346132
127MP0009643_abnormal_urine_homeostasis0.80935364
128MP0005166_decreased_susceptibility_to0.80734082
129MP0002933_joint_inflammation0.80502122
130MP0005253_abnormal_eye_physiology0.80369554
131MP0003646_muscle_fatigue0.80275790
132MP0005332_abnormal_amino_acid0.80101419
133MP0003191_abnormal_cellular_cholesterol0.79840248
134MP0002452_abnormal_antigen_presenting0.79521433
135MP0001849_ear_inflammation0.78959106
136MP0008469_abnormal_protein_level0.78531900
137MP0005584_abnormal_enzyme/coenzyme_acti0.78474440
138MP0003938_abnormal_ear_development0.78154665
139MP0002009_preneoplasia0.76474106
140MP0005623_abnormal_meninges_morphology0.76445601
141MP0000230_abnormal_systemic_arterial0.76192476
142MP0009840_abnormal_foam_cell0.76056393
143MP0008438_abnormal_cutaneous_collagen0.75633914
144MP0002405_respiratory_system_inflammati0.75604043
145MP0002736_abnormal_nociception_after0.75530582
146MP0008260_abnormal_autophagy0.75349510
147MP0009115_abnormal_fat_cell0.75196785
148MP0001666_abnormal_nutrient_absorption0.75114372
149MP0002896_abnormal_bone_mineralization0.74645664
150MP0004270_analgesia0.74562865
151MP0001545_abnormal_hematopoietic_system0.73966207
152MP0005397_hematopoietic_system_phenotyp0.73966207
153MP0003806_abnormal_nucleotide_metabolis0.73865177
154MP0001963_abnormal_hearing_physiology0.72764057
155MP0002136_abnormal_kidney_physiology0.72274426
156MP0002138_abnormal_hepatobiliary_system0.70570115
157MP0009250_abnormal_appendicular_skeleto0.70434220
158MP0002277_abnormal_respiratory_mucosa0.70027871
159MP0003880_abnormal_central_pattern0.69962264
160MP0000003_abnormal_adipose_tissue0.68134785
161MP0001664_abnormal_digestion0.67473936
162MP0001790_abnormal_immune_system0.66433267
163MP0005387_immune_system_phenotype0.66433267
164MP0003631_nervous_system_phenotype0.66408413
165MP0002132_abnormal_respiratory_system0.66158981
166MP0001486_abnormal_startle_reflex0.65792981
167MP0005195_abnormal_posterior_eye0.65066682
168MP0001529_abnormal_vocalization0.64956078
169MP0000470_abnormal_stomach_morphology0.61441209
170MP0001943_abnormal_respiration0.60639077
171MP0002272_abnormal_nervous_system0.59760010

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.14637102
2Genetic anticipation (HP:0003743)5.42085187
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.38656947
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.38656947
5Abnormality of glycolipid metabolism (HP:0010969)5.35048479
6Abnormality of liposaccharide metabolism (HP:0010968)5.35048479
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.35048479
8Prostate neoplasm (HP:0100787)5.00208584
9Action tremor (HP:0002345)4.89225714
10Interstitial pulmonary disease (HP:0006530)4.69784432
11Parakeratosis (HP:0001036)4.67301620
12Cerebral inclusion bodies (HP:0100314)4.41012724
13Dysmetric saccades (HP:0000641)4.01304463
14Systemic lupus erythematosus (HP:0002725)3.97401461
15Vacuolated lymphocytes (HP:0001922)3.77896067
16Progressive cerebellar ataxia (HP:0002073)3.67277638
17Sensory axonal neuropathy (HP:0003390)3.52217011
18Abnormality of the hepatic vasculature (HP:0006707)3.50030794
19Abnormality of the corticospinal tract (HP:0002492)3.46297550
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.44344547
21Abnormality of the phalanges of the 2nd finger (HP:0009541)3.43277033
22Dysostosis multiplex (HP:0000943)3.43182698
23Abnormality of the middle phalanges of the toes (HP:0010183)3.38505280
24Congenital ichthyosiform erythroderma (HP:0007431)3.34998022
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.34931639
26Abnormality of polysaccharide metabolism (HP:0011012)3.34931639
27Abnormality of glycosaminoglycan metabolism (HP:0004371)3.34931639
28Renal salt wasting (HP:0000127)3.29849375
29Peripheral hypomyelination (HP:0007182)3.29305824
30Mucopolysacchariduria (HP:0008155)3.28118532
31Urinary glycosaminoglycan excretion (HP:0003541)3.28118532
32Complement deficiency (HP:0004431)3.21312081
33Loss of speech (HP:0002371)3.16775215
34Increased cerebral lipofuscin (HP:0011813)3.14330800
35Stomach cancer (HP:0012126)3.10568892
36Hypokalemic alkalosis (HP:0001949)3.08295712
37Synostosis involving the elbow (HP:0003938)3.05223906
38Humeroradial synostosis (HP:0003041)3.05223906
39Onion bulb formation (HP:0003383)3.03155523
40Aplasia involving bones of the upper limbs (HP:0009823)3.02962998
41Aplasia of the phalanges of the hand (HP:0009802)3.02962998
42Aplasia involving bones of the extremities (HP:0009825)3.02962998
43Alacrima (HP:0000522)3.00072881
44Supranuclear gaze palsy (HP:0000605)2.98487079
45Ulnar bowing (HP:0003031)2.94911970
46Myocardial infarction (HP:0001658)2.90830079
47Stenosis of the external auditory canal (HP:0000402)2.90818962
48Premature skin wrinkling (HP:0100678)2.89344085
49Thickened helices (HP:0000391)2.88684226
50Glomerulonephritis (HP:0000099)2.85129383
51Intention tremor (HP:0002080)2.84853619
52Gaze-evoked nystagmus (HP:0000640)2.83682432
53Stridor (HP:0010307)2.80532005
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.80511005
55Hyperactive renin-angiotensin system (HP:0000841)2.79898847
56Hyperventilation (HP:0002883)2.79121407
57Keratoconus (HP:0000563)2.77267472
58Increased corneal curvature (HP:0100692)2.77267472
59Onycholysis (HP:0001806)2.76637759
60Tubulointerstitial fibrosis (HP:0005576)2.66829074
61Anteriorly placed anus (HP:0001545)2.64217196
62Morphological abnormality of the inner ear (HP:0011390)2.63905809
63Pendular nystagmus (HP:0012043)2.62528025
64Barrel-shaped chest (HP:0001552)2.60284930
65Abnormality of the 2nd finger (HP:0004100)2.60064285
66Tubular atrophy (HP:0000092)2.55647360
67Hematochezia (HP:0002573)2.53898950
68Cupped ear (HP:0000378)2.53844679
69Increased circulating renin level (HP:0000848)2.53589292
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53226575
71Hypomagnesemia (HP:0002917)2.53089801
72Metabolic alkalosis (HP:0200114)2.51887880
73Coronal craniosynostosis (HP:0004440)2.49790755
74Split foot (HP:0001839)2.49450493
75Postural tremor (HP:0002174)2.44069012
76Abnormality of chloride homeostasis (HP:0011422)2.43708938
77Segmental peripheral demyelination/remyelination (HP:0003481)2.42709265
78Abnormality of the prostate (HP:0008775)2.42688775
79Megalencephaly (HP:0001355)2.41476119
80Hypotrichosis (HP:0001006)2.41474029
81Abnormal drinking behavior (HP:0030082)2.39714633
82Polydipsia (HP:0001959)2.39714633
83Abnormality of complement system (HP:0005339)2.39367586
84Congenital sensorineural hearing impairment (HP:0008527)2.38120497
85Autoamputation (HP:0001218)2.37775124
86Respiratory distress (HP:0002098)2.34191813
87Cerebral hypomyelination (HP:0006808)2.32845833
88Abnormal auditory evoked potentials (HP:0006958)2.32734642
89Fragile nails (HP:0001808)2.32635374
90Abnormality of macrophages (HP:0004311)2.31771997
91Partial duplication of thumb phalanx (HP:0009944)2.31371332
92Bifid scrotum (HP:0000048)2.29791346
93Steatorrhea (HP:0002570)2.29787463
94Esophageal atresia (HP:0002032)2.29695681
95Hyperaldosteronism (HP:0000859)2.28828307
96Ovoid vertebral bodies (HP:0003300)2.28368249
97Cerebral hemorrhage (HP:0001342)2.26833075
98Absence seizures (HP:0002121)2.26533691
99Nephritis (HP:0000123)2.26247508
100Decreased circulating renin level (HP:0003351)2.25036573
101Abnormality of cochlea (HP:0000375)2.23900241
102Hyperkalemia (HP:0002153)2.22106855
103Autoimmune thrombocytopenia (HP:0001973)2.18972396
104Abnormality of renin-angiotensin system (HP:0000847)2.18947346
105Woolly hair (HP:0002224)2.18818503
106Bone cyst (HP:0012062)2.18242032
107Erythroderma (HP:0001019)2.17873322
108Decreased lacrimation (HP:0000633)2.14443706
109Follicular hyperkeratosis (HP:0007502)2.13620419
110Portal hypertension (HP:0001409)2.11452395
111Abnormality of incisor morphology (HP:0011063)2.09663131
112Severe visual impairment (HP:0001141)2.08102525
113Hepatosplenomegaly (HP:0001433)2.06926558
114Hypoplasia of the odontoid process (HP:0003311)2.06791465
115Nasolacrimal duct obstruction (HP:0000579)2.06112726
116Slow saccadic eye movements (HP:0000514)2.03735512
117Xanthomatosis (HP:0000991)2.02980602
118Spondylolisthesis (HP:0003302)2.02950340
119Hyporeflexia of lower limbs (HP:0002600)2.01943638
120Mixed hearing impairment (HP:0000410)2.01562077
121Insidious onset (HP:0003587)2.00065576
122Termporal pattern (HP:0011008)2.00065576
123Glomerulosclerosis (HP:0000096)1.99195389
124Fair hair (HP:0002286)1.98824144
125Abnormal umbilical cord blood vessels (HP:0011403)1.97899596
126Single umbilical artery (HP:0001195)1.97899596
127Abnormality of the fetal cardiovascular system (HP:0010948)1.97899596
128Metaphyseal irregularity (HP:0003025)1.95523634
129Corneal erosion (HP:0200020)1.95487076
130Mutism (HP:0002300)1.95432381
131Short hallux (HP:0010109)1.95365304
132Partial duplication of the phalanx of hand (HP:0009999)1.94682691
133Tachypnea (HP:0002789)1.93901748
134Polyuria (HP:0000103)1.93824379
135Prolonged neonatal jaundice (HP:0006579)1.93803527
136Hypoplastic labia majora (HP:0000059)1.92807336
137Urinary bladder sphincter dysfunction (HP:0002839)1.92298977
138Muscle fiber splitting (HP:0003555)1.91367606
139Hypoplasia of the iris (HP:0007676)1.89897158
140Abolished electroretinogram (ERG) (HP:0000550)1.87968115
141Macular degeneration (HP:0000608)1.87418555
142Abnormality of the periventricular white matter (HP:0002518)1.87253146
143Neoplasm of head and neck (HP:0012288)1.86857105
144Esophageal neoplasm (HP:0100751)1.86857105
145Tubulointerstitial abnormality (HP:0001969)1.86797978
146Symphalangism affecting the phalanges of the hand (HP:0009773)1.86615658
147Thick nail (HP:0001805)1.85926212
148Bell-shaped thorax (HP:0001591)1.85427327
149Abnormality of proline metabolism (HP:0010907)1.84840190
150Hydroxyprolinuria (HP:0003080)1.84840190
151Clumsiness (HP:0002312)1.84821811
152Conical tooth (HP:0000698)1.84383410
153Seborrheic dermatitis (HP:0001051)1.84171292
154Retinal atrophy (HP:0001105)1.84138171
155Abnormality of macular pigmentation (HP:0008002)1.83968733
156Chronic otitis media (HP:0000389)1.82550897
157Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82231503
158Postural instability (HP:0002172)1.82108073
159Adrenal hypoplasia (HP:0000835)1.80298793
160Small epiphyses (HP:0010585)1.79769888
161Abnormality of magnesium homeostasis (HP:0004921)1.79602661
162Macroglossia (HP:0000158)1.79434459
163Spastic gait (HP:0002064)1.79429563
164Pancreatic cysts (HP:0001737)1.78554060
165Recurrent gram-negative bacterial infections (HP:0005420)1.78186252
166Broad metatarsal (HP:0001783)1.78004772
167Disproportionate short-trunk short stature (HP:0003521)1.77298424
168Congenital stationary night blindness (HP:0007642)1.75380291
169Increased CSF protein (HP:0002922)1.74836939
170Abnormality of the renal cortex (HP:0011035)1.73839049
171Retinal dysplasia (HP:0007973)1.73744823
172Abnormality of molar (HP:0011077)1.73603970
173Abnormality of molar morphology (HP:0011070)1.73603970
174Aplasia/Hypoplasia of the hallux (HP:0008362)1.73195299
175Dialeptic seizures (HP:0011146)1.72804758
176Mitral stenosis (HP:0001718)1.72487695
177Axonal loss (HP:0003447)1.71738277
178Xerostomia (HP:0000217)1.71401018
179Abnormality of the salivary glands (HP:0010286)1.70935171
180Congenital, generalized hypertrichosis (HP:0004540)1.70796906
181Abnormality of renal excretion (HP:0011036)1.70231809
182Abnormal urine output (HP:0012590)1.68895478
183Thyroid-stimulating hormone excess (HP:0002925)1.68543210
184Generalized hypopigmentation of hair (HP:0011358)1.68325448
185Amyloidosis (HP:0011034)1.67193859
186Poor head control (HP:0002421)1.64494614
187Joint stiffness (HP:0001387)1.64212244
188Chorioretinal atrophy (HP:0000533)1.63037221
189Widely spaced teeth (HP:0000687)1.60487835
190Metaphyseal dysplasia (HP:0100255)1.60291838
191Pulmonary artery stenosis (HP:0004415)1.60001125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.41295319
2EPHB14.39767814
3OXSR14.15237335
4MST44.02306838
5FGFR23.79520686
6WNK43.08202330
7ACVR1B3.02862133
8ADRBK22.83434958
9MAP4K22.65940905
10PBK2.61735306
11BCR2.38252104
12MAPKAPK52.27339344
13PKN12.26827490
14TAOK32.15577409
15MET2.12505014
16PDK22.11571936
17WNK12.05868906
18MAPK151.63132800
19CLK11.60931430
20LIMK11.60702255
21CSNK1A1L1.49532070
22PINK11.44156502
23CAMKK21.40817383
24PRPF4B1.35951128
25SGK2231.33956810
26SGK4941.33956810
27EPHA21.33795924
28ROCK21.32328307
29GRK71.29876194
30NEK61.24778137
31MAPKAPK31.24701257
32CSNK1G31.23571898
33IKBKB1.21312075
34ABL21.20876957
35TESK21.19732546
36ADRBK11.19219889
37CAMK2B1.18671332
38TRPM71.18431849
39STK101.14357736
40JAK11.14244714
41CSNK1G11.10903699
42EPHA31.10502753
43PRKD11.09381867
44PRKAA21.05452418
45MAP2K21.05288480
46TGFBR11.03817368
47DAPK21.02841596
48PRKCQ1.02493151
49TXK1.01957766
50STK38L1.01577245
51KIT1.00610557
52TYK20.99599866
53NTRK10.96032566
54NEK90.94619636
55PAK30.93365318
56MAP3K20.93275200
57PDGFRB0.92839641
58MUSK0.91988318
59IRAK30.87141654
60CDK190.86029868
61LRRK20.85567657
62FGR0.83961143
63UHMK10.83735252
64GSK3A0.81808795
65MARK20.81669312
66CSNK1G20.81402152
67MAP3K130.81274706
68WNK30.80018323
69TYRO30.79800665
70CAMK2D0.78867272
71HIPK20.75882765
72TIE10.75430395
73MYLK0.74981363
74PDK10.74914307
75CHUK0.73655635
76ITK0.73637383
77JAK20.73444037
78RPS6KA50.72639572
79ICK0.72380144
80LATS10.70271892
81FER0.69742025
82LATS20.68388049
83DDR20.66531318
84STK380.66061608
85ERN10.65835327
86PRKCE0.63942274
87GRK10.62759255
88BMPR1B0.62716948
89NLK0.60151621
90JAK30.59752256
91CAMK2G0.59741809
92STK40.58904502
93STK110.58427355
94TBK10.54888418
95FGFR30.52859813
96MAP3K140.52605952
97DYRK20.51434941
98CDC42BPA0.51105269
99MAPK120.50037757
100MATK0.49172950
101PDPK10.49006506
102PTK2B0.48742813
103CSNK1D0.48383477
104IGF1R0.48013096
105MELK0.47858250
106FYN0.47529315
107CAMK1D0.47378409
108STK240.45146175
109CSK0.44334539
110NUAK10.43358397
111MAP2K10.42729640
112PRKCH0.40495198
113IKBKE0.40193771
114MAPK70.39866975
115MKNK20.39629430
116MAP2K60.39606696
117MAPK40.39220953
118FRK0.38394081
119YES10.37965490
120CSF1R0.37902102
121MAP3K30.37898383
122INSRR0.37829222
123MST1R0.37200173
124INSR0.37178385
125MAPKAPK20.34919863
126FGFR10.34760180
127BCKDK0.33371909
128ZAP700.33046723
129EPHB20.32473498
130CSNK1A10.32334555
131SGK20.32318141
132DMPK0.31844696
133BRSK20.31640620
134RPS6KA20.31394192
135PTK60.31153854
136CAMK2A0.30881816
137STK30.30650387
138ABL10.30490624
139TGFBR20.29914915
140TNK20.29658535
141PRKG10.29522100
142MAP3K70.29408657
143CASK0.28793045
144PTK20.28463147
145ILK0.27939149
146AKT30.27644735
147PNCK0.27055600
148BLK0.26469480
149ROCK10.24553476
150FGFR40.24504702
151IRAK10.22569897
152PIK3CA0.22432144
153EGFR0.21914350
154PRKD20.21164684

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.38335063
2Fatty acid elongation_Homo sapiens_hsa000624.28323780
3Steroid biosynthesis_Homo sapiens_hsa001004.22138619
4Primary bile acid biosynthesis_Homo sapiens_hsa001204.01922138
5Ether lipid metabolism_Homo sapiens_hsa005653.15607113
6Sulfur metabolism_Homo sapiens_hsa009202.97353508
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.55822495
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45550309
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38777694
10Staphylococcus aureus infection_Homo sapiens_hsa051502.26509203
11Sphingolipid metabolism_Homo sapiens_hsa006002.20569185
12Tryptophan metabolism_Homo sapiens_hsa003802.19846704
13Histidine metabolism_Homo sapiens_hsa003402.18160553
14Complement and coagulation cascades_Homo sapiens_hsa046102.14503409
15Nitrogen metabolism_Homo sapiens_hsa009102.02655908
16Other glycan degradation_Homo sapiens_hsa005112.02512861
17Protein export_Homo sapiens_hsa030601.97082300
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.89710438
19PPAR signaling pathway_Homo sapiens_hsa033201.83073715
20Mineral absorption_Homo sapiens_hsa049781.79445185
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79410833
22Tight junction_Homo sapiens_hsa045301.77827012
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76244536
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.73764058
25Caffeine metabolism_Homo sapiens_hsa002321.71584385
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70840710
27Linoleic acid metabolism_Homo sapiens_hsa005911.70561546
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62396626
29Axon guidance_Homo sapiens_hsa043601.55878243
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.49437968
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35662959
32Asthma_Homo sapiens_hsa053101.34904699
33ECM-receptor interaction_Homo sapiens_hsa045121.34574206
34Pertussis_Homo sapiens_hsa051331.29125402
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28709719
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26916388
37Renal cell carcinoma_Homo sapiens_hsa052111.26305354
38Glutathione metabolism_Homo sapiens_hsa004801.25384662
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.25191570
40Allograft rejection_Homo sapiens_hsa053301.21414618
41Vibrio cholerae infection_Homo sapiens_hsa051101.18970072
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13883545
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13724227
44Arachidonic acid metabolism_Homo sapiens_hsa005901.08890978
45Graft-versus-host disease_Homo sapiens_hsa053321.08100026
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07550400
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06983410
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06887779
49Fatty acid degradation_Homo sapiens_hsa000711.03791788
50Vitamin B6 metabolism_Homo sapiens_hsa007501.02022568
51Lysosome_Homo sapiens_hsa041421.01170961
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99132890
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98814407
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95688486
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.93268896
56Chemical carcinogenesis_Homo sapiens_hsa052040.92954997
57Collecting duct acid secretion_Homo sapiens_hsa049660.89783309
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87746651
59Circadian rhythm_Homo sapiens_hsa047100.85752130
60Osteoclast differentiation_Homo sapiens_hsa043800.85240415
61Rheumatoid arthritis_Homo sapiens_hsa053230.85177901
62Hippo signaling pathway_Homo sapiens_hsa043900.84154129
63Endocytosis_Homo sapiens_hsa041440.80652846
64Butanoate metabolism_Homo sapiens_hsa006500.80441855
65Prostate cancer_Homo sapiens_hsa052150.78855044
66Leishmaniasis_Homo sapiens_hsa051400.77912551
67Arginine and proline metabolism_Homo sapiens_hsa003300.76516187
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74712855
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.73428333
70Fat digestion and absorption_Homo sapiens_hsa049750.73194075
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72620959
72TNF signaling pathway_Homo sapiens_hsa046680.72041712
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71967364
74Tuberculosis_Homo sapiens_hsa051520.70793467
75Dorso-ventral axis formation_Homo sapiens_hsa043200.69671032
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.69601749
77Pancreatic secretion_Homo sapiens_hsa049720.69136463
78African trypanosomiasis_Homo sapiens_hsa051430.68915186
79Tyrosine metabolism_Homo sapiens_hsa003500.68565793
80Type I diabetes mellitus_Homo sapiens_hsa049400.68007687
81Hematopoietic cell lineage_Homo sapiens_hsa046400.67504283
82Adherens junction_Homo sapiens_hsa045200.67139901
83ABC transporters_Homo sapiens_hsa020100.67008784
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.66733199
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.66568760
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66433051
87Gastric acid secretion_Homo sapiens_hsa049710.66122723
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65314347
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62339643
90Phagosome_Homo sapiens_hsa041450.61943205
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61702308
92Ras signaling pathway_Homo sapiens_hsa040140.61368782
93Basal cell carcinoma_Homo sapiens_hsa052170.61305604
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.61117914
95Protein digestion and absorption_Homo sapiens_hsa049740.60946708
96Bile secretion_Homo sapiens_hsa049760.60271876
97Malaria_Homo sapiens_hsa051440.59588206
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59156978
99Phenylalanine metabolism_Homo sapiens_hsa003600.59154894
100Hedgehog signaling pathway_Homo sapiens_hsa043400.58547559
101B cell receptor signaling pathway_Homo sapiens_hsa046620.54958745
102Hepatitis C_Homo sapiens_hsa051600.54623286
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.53818680
104Focal adhesion_Homo sapiens_hsa045100.53457772
105Serotonergic synapse_Homo sapiens_hsa047260.53327403
106Starch and sucrose metabolism_Homo sapiens_hsa005000.52988953
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.50802195
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50622159
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50380402
110Ovarian steroidogenesis_Homo sapiens_hsa049130.49230536
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47632842
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45964123
113Fatty acid biosynthesis_Homo sapiens_hsa000610.45941270
114Toxoplasmosis_Homo sapiens_hsa051450.45857065
115Inositol phosphate metabolism_Homo sapiens_hsa005620.45048825
116Influenza A_Homo sapiens_hsa051640.43640596
117Long-term depression_Homo sapiens_hsa047300.43137055
118Choline metabolism in cancer_Homo sapiens_hsa052310.42883288
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42491084
120Oxidative phosphorylation_Homo sapiens_hsa001900.42166329
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41580453
122Renin-angiotensin system_Homo sapiens_hsa046140.41139885
123Vitamin digestion and absorption_Homo sapiens_hsa049770.40636450
124Retinol metabolism_Homo sapiens_hsa008300.40589601
125Primary immunodeficiency_Homo sapiens_hsa053400.40382402
126Rap1 signaling pathway_Homo sapiens_hsa040150.39986479
127Legionellosis_Homo sapiens_hsa051340.39295435
128Insulin resistance_Homo sapiens_hsa049310.39254879
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39160329
130Fatty acid metabolism_Homo sapiens_hsa012120.38827431
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38809948
132Pathways in cancer_Homo sapiens_hsa052000.38463704
133Phototransduction_Homo sapiens_hsa047440.38266969
134T cell receptor signaling pathway_Homo sapiens_hsa046600.38016993
135Cocaine addiction_Homo sapiens_hsa050300.36706047
136Propanoate metabolism_Homo sapiens_hsa006400.35839993
137TGF-beta signaling pathway_Homo sapiens_hsa043500.35511344
138Glycerolipid metabolism_Homo sapiens_hsa005610.34823246
139Chemokine signaling pathway_Homo sapiens_hsa040620.33961565
140Selenocompound metabolism_Homo sapiens_hsa004500.33827813
141beta-Alanine metabolism_Homo sapiens_hsa004100.33503312
142Platelet activation_Homo sapiens_hsa046110.33438216
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32913829
144Salivary secretion_Homo sapiens_hsa049700.32848292
145Autoimmune thyroid disease_Homo sapiens_hsa053200.32444664
146ErbB signaling pathway_Homo sapiens_hsa040120.31774795
147Pancreatic cancer_Homo sapiens_hsa052120.31624193
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31609786
149Amoebiasis_Homo sapiens_hsa051460.30690095
150Peroxisome_Homo sapiens_hsa041460.30497203
151NF-kappa B signaling pathway_Homo sapiens_hsa040640.29670964
152Maturity onset diabetes of the young_Homo sapiens_hsa049500.29373428
153Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29115860

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