CPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.67038133
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.67038133
3L-phenylalanine metabolic process (GO:0006558)7.34355051
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.34355051
5aromatic amino acid family catabolic process (GO:0009074)6.77378917
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.31198603
7epoxygenase P450 pathway (GO:0019373)6.12835127
8indole-containing compound catabolic process (GO:0042436)6.01206902
9indolalkylamine catabolic process (GO:0046218)6.01206902
10tryptophan catabolic process (GO:0006569)6.01206902
11regulation of plasminogen activation (GO:0010755)5.93046584
12kynurenine metabolic process (GO:0070189)5.90486324
13omega-hydroxylase P450 pathway (GO:0097267)5.89948638
14exogenous drug catabolic process (GO:0042738)5.82243367
15bile acid biosynthetic process (GO:0006699)5.77593110
16glyoxylate metabolic process (GO:0046487)5.77589584
17tryptophan metabolic process (GO:0006568)5.70143000
18positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.61434088
19negative regulation of fibrinolysis (GO:0051918)5.57498185
20high-density lipoprotein particle remodeling (GO:0034375)5.56172763
21alpha-linolenic acid metabolic process (GO:0036109)5.55668528
22urea cycle (GO:0000050)5.46775690
23urea metabolic process (GO:0019627)5.46775690
24cysteine metabolic process (GO:0006534)5.43975636
25regulation of fibrinolysis (GO:0051917)5.37317746
26sulfur amino acid catabolic process (GO:0000098)5.34150240
27protein carboxylation (GO:0018214)5.33286498
28peptidyl-glutamic acid carboxylation (GO:0017187)5.33286498
29regulation of protein activation cascade (GO:2000257)5.21829573
30complement activation, alternative pathway (GO:0006957)5.16388627
31serine family amino acid catabolic process (GO:0009071)5.12832281
32nitrogen cycle metabolic process (GO:0071941)5.03686387
33bile acid metabolic process (GO:0008206)4.98845233
34aromatic amino acid family metabolic process (GO:0009072)4.96191963
35reverse cholesterol transport (GO:0043691)4.91516655
36regulation of cholesterol esterification (GO:0010872)4.85160698
37regulation of complement activation (GO:0030449)4.84928014
38negative regulation of protein activation cascade (GO:2000258)4.81426215
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80449017
40tyrosine metabolic process (GO:0006570)4.76877046
41homocysteine metabolic process (GO:0050667)4.76638957
42macromolecular complex remodeling (GO:0034367)4.75466033
43plasma lipoprotein particle remodeling (GO:0034369)4.75466033
44protein-lipid complex remodeling (GO:0034368)4.75466033
45regulation of triglyceride catabolic process (GO:0010896)4.74425775
46acute-phase response (GO:0006953)4.69397219
47acylglycerol homeostasis (GO:0055090)4.64536842
48triglyceride homeostasis (GO:0070328)4.64536842
49alpha-amino acid catabolic process (GO:1901606)4.61803517
50lysine metabolic process (GO:0006553)4.60264025
51lysine catabolic process (GO:0006554)4.60264025
52drug metabolic process (GO:0017144)4.59089564
53phospholipid efflux (GO:0033700)4.58775446
54negative regulation of blood coagulation (GO:0030195)4.58433343
55negative regulation of hemostasis (GO:1900047)4.58433343
56regulation of humoral immune response (GO:0002920)4.57589099
57amino-acid betaine metabolic process (GO:0006577)4.55386936
58oxidative demethylation (GO:0070989)4.54541258
59negative regulation of cholesterol transport (GO:0032375)4.53466239
60negative regulation of sterol transport (GO:0032372)4.53466239
61protein-lipid complex subunit organization (GO:0071825)4.51192268
62glycine metabolic process (GO:0006544)4.45730860
63cellular ketone body metabolic process (GO:0046950)4.44081656
64coenzyme catabolic process (GO:0009109)4.36572339
65plasma lipoprotein particle clearance (GO:0034381)4.35402471
66bile acid and bile salt transport (GO:0015721)4.32903441
67indolalkylamine metabolic process (GO:0006586)4.30837393
68cellular amino acid catabolic process (GO:0009063)4.27271217
69imidazole-containing compound metabolic process (GO:0052803)4.24271075
70serine family amino acid metabolic process (GO:0009069)4.23993315
71glutamate metabolic process (GO:0006536)4.21197066
72negative regulation of coagulation (GO:0050819)4.20790522
73cholesterol efflux (GO:0033344)4.19397293
74amine catabolic process (GO:0009310)4.17189318
75cellular biogenic amine catabolic process (GO:0042402)4.17189318
76phenylpropanoid metabolic process (GO:0009698)4.15494224
77cellular modified amino acid catabolic process (GO:0042219)4.12567634
78serine family amino acid biosynthetic process (GO:0009070)4.09419516
79negative regulation of wound healing (GO:0061045)4.09315984
80ethanol metabolic process (GO:0006067)4.01565830
81benzene-containing compound metabolic process (GO:0042537)4.00935515
82cellular glucuronidation (GO:0052695)4.00629776
83plasma lipoprotein particle assembly (GO:0034377)3.99339082
84positive regulation of blood coagulation (GO:0030194)3.93974709
85positive regulation of hemostasis (GO:1900048)3.93974709
86fibrinolysis (GO:0042730)3.93452278
87dicarboxylic acid biosynthetic process (GO:0043650)3.89624929
88aldehyde catabolic process (GO:0046185)3.89548778
89ethanol oxidation (GO:0006069)3.89441969
90arginine metabolic process (GO:0006525)3.88052782
91regulation of apoptotic cell clearance (GO:2000425)3.87725671
92low-density lipoprotein particle remodeling (GO:0034374)3.87134581
93ketone body metabolic process (GO:1902224)3.83993279
94positive regulation of triglyceride lipase activity (GO:0061365)3.83105523
95positive regulation of lipoprotein lipase activity (GO:0051006)3.83105523
96opsonization (GO:0008228)3.81694586
97drug catabolic process (GO:0042737)3.81432664
98proline metabolic process (GO:0006560)3.80690593
99heme transport (GO:0015886)3.80001531
100intestinal cholesterol absorption (GO:0030299)3.78964489
101blood coagulation, intrinsic pathway (GO:0007597)3.78301378
102positive regulation of fatty acid biosynthetic process (GO:0045723)3.77031878
103flavonoid metabolic process (GO:0009812)3.75145220
104organic acid catabolic process (GO:0016054)3.75020280
105carboxylic acid catabolic process (GO:0046395)3.75020280
106regulation of cholesterol homeostasis (GO:2000188)3.73997257
107phospholipid homeostasis (GO:0055091)3.73462671
108cholesterol homeostasis (GO:0042632)3.72853284
109cofactor catabolic process (GO:0051187)3.72685474
110negative regulation of complement activation (GO:0045916)3.67176213
111sterol homeostasis (GO:0055092)3.66951558
112short-chain fatty acid metabolic process (GO:0046459)3.65991666
113negative regulation of lipase activity (GO:0060192)3.65912115
114complement activation, classical pathway (GO:0006958)3.65824393
115positive regulation of coagulation (GO:0050820)3.65211992
116regulation of bile acid biosynthetic process (GO:0070857)3.65116797
117positive regulation of lipid catabolic process (GO:0050996)3.64368303
118lipoprotein metabolic process (GO:0042157)3.63327676
119acute inflammatory response (GO:0002526)3.62509596
120very-low-density lipoprotein particle assembly (GO:0034379)3.62444570
121plasma lipoprotein particle organization (GO:0071827)3.61597315
122protein activation cascade (GO:0072376)3.60024829
123complement activation (GO:0006956)3.59025350
124acetyl-CoA metabolic process (GO:0006084)3.57921045
125cytolysis (GO:0019835)3.56667996
126uronic acid metabolic process (GO:0006063)3.56260453
127glucuronate metabolic process (GO:0019585)3.56260453
128protein-lipid complex assembly (GO:0065005)3.56020101
129cholesterol transport (GO:0030301)3.52713923
130sterol transport (GO:0015918)3.52713923
131aspartate family amino acid catabolic process (GO:0009068)3.49475033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.36814816
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22807992
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.85343265
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.47421861
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32049588
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.22148906
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74072233
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.09619169
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96056762
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.12696676
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03913125
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02950787
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8897854
14GATA1_22025678_ChIP-Seq_K562_Human1.71022462
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59527867
16CLOCK_20551151_ChIP-Seq_293T_Human1.58513257
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57827919
18HTT_18923047_ChIP-ChIP_STHdh_Human1.52855741
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42320558
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31343660
21IGF1R_20145208_ChIP-Seq_DFB_Human1.28170816
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27155184
23* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19933581
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17002178
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16184542
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10329523
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08745398
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07649369
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96706311
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96449040
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95001241
32GATA4_25053715_ChIP-Seq_YYC3_Human0.94628833
33TCF4_18268006_ChIP-ChIP_LS174T_Human0.92970536
34ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91840752
35NFE2_27457419_Chip-Seq_LIVER_Mouse0.90618318
36SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85977720
37IRF8_22096565_ChIP-ChIP_GC-B_Human0.85601086
38PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84781684
39SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84091733
40SOX2_21211035_ChIP-Seq_LN229_Human0.84049595
41RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83828430
42RARA_24833708_ChIP-Seq_LIVER_Mouse0.82372419
43KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81829342
44BCAT_22108803_ChIP-Seq_LS180_Human0.81234248
45ESR1_20079471_ChIP-ChIP_T-47D_Human0.80552420
46NANOG_19829295_ChIP-Seq_ESCs_Human0.80356485
47SOX2_19829295_ChIP-Seq_ESCs_Human0.80356485
48RAC3_21632823_ChIP-Seq_H3396_Human0.80191831
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80034107
50* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.79714852
51ER_23166858_ChIP-Seq_MCF-7_Human0.78124455
52AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77675163
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77195383
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76809614
55MYC_19829295_ChIP-Seq_ESCs_Human0.76537809
56* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76351157
57ZNF263_19887448_ChIP-Seq_K562_Human0.76294909
58SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73199006
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72247258
60ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72030250
61* OCT4_20526341_ChIP-Seq_ESCs_Human0.71820756
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.71485697
63EZH2_27294783_Chip-Seq_NPCs_Mouse0.70929117
64RARB_24833708_ChIP-Seq_LIVER_Mouse0.70922379
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69741986
66ESR2_21235772_ChIP-Seq_MCF-7_Human0.68415864
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68090103
68SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67687411
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67586980
70FOXH1_21741376_ChIP-Seq_EPCs_Human0.66629397
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65841601
72SMAD1_18555785_Chip-Seq_ESCs_Mouse0.65800566
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65497276
74KLF5_20875108_ChIP-Seq_MESCs_Mouse0.64948174
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.63663904
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62957722
77FOXH1_21741376_ChIP-Seq_ESCs_Human0.62700329
78ERA_21632823_ChIP-Seq_H3396_Human0.62552365
79RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62279809
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61571199
81CDX2_22108803_ChIP-Seq_LS180_Human0.61086265
82E2F1_20622854_ChIP-Seq_HELA_Human0.60430183
83FOXA1_25552417_ChIP-Seq_VCAP_Human0.60403429
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59512292
85ESR1_21235772_ChIP-Seq_MCF-7_Human0.59347149
86LXR_22292898_ChIP-Seq_THP-1_Human0.58623861
87AR_20517297_ChIP-Seq_VCAP_Human0.58480659
88AR_21572438_ChIP-Seq_LNCaP_Human0.58395679
89NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.58163233
90FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57968814
91SPI1_20517297_ChIP-Seq_HL60_Human0.57747819
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.57365861
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.56735358
94POU5F1_16518401_ChIP-PET_MESCs_Mouse0.56670026
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.56619050
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.56524424
97CEBPB_22108803_ChIP-Seq_LS180_Human0.56416279
98SOX11_22085726_ChIP-Seq_ESNs_Mouse0.56224387
99ESRRB_18555785_Chip-Seq_ESCs_Mouse0.56069209
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55934773
101OCT4_18555785_Chip-Seq_ESCs_Mouse0.55895030
102* NCOR_22424771_ChIP-Seq_293T_Human0.55600103
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55527188
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.54933679
105RUNX1_27457419_Chip-Seq_LIVER_Mouse0.54568117
106FOXA1_25329375_ChIP-Seq_VCAP_Human0.54150323
107FOXA1_27270436_Chip-Seq_PROSTATE_Human0.54150323
108CRX_20693478_ChIP-Seq_RETINA_Mouse0.53885773
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53869029
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52949700
111MYC_19915707_ChIP-ChIP_AK7_Human0.52698891
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.52619418
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.52619418
114GATA3_21878914_ChIP-Seq_MCF-7_Human0.51848695
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.51768483
116GATA6_25053715_ChIP-Seq_YYC3_Human0.51763896
117ZFX_18555785_Chip-Seq_ESCs_Mouse0.51665030
118ESET_19884257_ChIP-Seq_ESCs_Mouse0.51164428
119SOX2_22085726_ChIP-Seq_NPCs_Mouse0.50838337
120P53_21459846_ChIP-Seq_SAOS-2_Human0.50786897
121GATA1_19941826_ChIP-Seq_K562_Human0.47078315
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46666982
123TAF2_19829295_ChIP-Seq_ESCs_Human0.46650889
124EGR1_19032775_ChIP-ChIP_M12_Human0.45800437
125STAT1_17558387_ChIP-Seq_HELA_Human0.45150461
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44184329
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43830666
128* CBP_21632823_ChIP-Seq_H3396_Human0.43181562
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43138753
130ERG_20517297_ChIP-Seq_VCAP_Human0.42429382
131* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42080998
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.41064427
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.40721023
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.39555198
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.39211166
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.38163573
137SPI1_26923725_Chip-Seq_HPCs_Mouse0.38035627
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.37475224
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37430869
140GATA2_19941826_ChIP-Seq_K562_Human0.36487901
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36449354
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.36338855
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.36116728
144LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35996138
145BCOR_27268052_Chip-Seq_Bcells_Human0.35983588
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.35583439
147SOX2_20726797_ChIP-Seq_SW620_Human0.34177931
148P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34136982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17838845
2MP0005360_urolithiasis7.29172604
3MP0005085_abnormal_gallbladder_physiolo6.35043225
4MP0005365_abnormal_bile_salt6.32633999
5MP0008875_abnormal_xenobiotic_pharmacok4.86218438
6MP0003806_abnormal_nucleotide_metabolis4.24730786
7MP0003252_abnormal_bile_duct3.88881675
8MP0010329_abnormal_lipoprotein_level3.53836232
9MP0005083_abnormal_biliary_tract3.37438765
10MP0009840_abnormal_foam_cell3.32272019
11MP0003195_calcinosis3.15643920
12MP0001666_abnormal_nutrient_absorption2.89541689
13MP0005332_abnormal_amino_acid2.82549707
14MP0003191_abnormal_cellular_cholesterol2.33711852
15MP0004019_abnormal_vitamin_homeostasis2.22025576
16MP0000609_abnormal_liver_physiology2.15589676
17MP0002118_abnormal_lipid_homeostasis2.13445184
18MP0003868_abnormal_feces_composition2.07398313
19MP0002138_abnormal_hepatobiliary_system2.06611246
20MP0003136_yellow_coat_color1.83670080
21MP0005319_abnormal_enzyme/_coenzyme1.80429652
22MP0001764_abnormal_homeostasis1.71712044
23MP0005171_absent_coat_pigmentation1.60223575
24MP0005584_abnormal_enzyme/coenzyme_acti1.50436424
25MP0009697_abnormal_copulation1.47721416
26MP0005451_abnormal_body_composition1.47028915
27MP0009643_abnormal_urine_homeostasis1.39301105
28MP0003186_abnormal_redox_activity1.27550393
29MP0003011_delayed_dark_adaptation1.26811006
30MP0003656_abnormal_erythrocyte_physiolo1.21801811
31MP0000598_abnormal_liver_morphology1.18052073
32MP0002132_abnormal_respiratory_system1.15933997
33MP0005220_abnormal_exocrine_pancreas1.15492909
34MP0001915_intracranial_hemorrhage1.09982967
35MP0003705_abnormal_hypodermis_morpholog1.09805726
36MP0005084_abnormal_gallbladder_morpholo1.08473402
37MP0003879_abnormal_hair_cell1.06812266
38MP0005636_abnormal_mineral_homeostasis1.06131985
39MP0005647_abnormal_sex_gland1.03708949
40MP0000604_amyloidosis1.02321016
41MP0003122_maternal_imprinting0.97205650
42MP0009763_increased_sensitivity_to0.95350244
43MP0002078_abnormal_glucose_homeostasis0.94620345
44MP0002938_white_spotting0.94562575
45MP0005408_hypopigmentation0.94351178
46MP0009764_decreased_sensitivity_to0.90884652
47MP0009642_abnormal_blood_homeostasis0.90511962
48MP0010368_abnormal_lymphatic_system0.90157168
49MP0006036_abnormal_mitochondrial_physio0.88069585
50MP0002254_reproductive_system_inflammat0.87922108
51MP0000372_irregular_coat_pigmentation0.87371704
52MP0002089_abnormal_postnatal_growth/wei0.86662759
53MP0008469_abnormal_protein_level0.86220313
54MP0003878_abnormal_ear_physiology0.81930122
55MP0005377_hearing/vestibular/ear_phenot0.81930122
56MP0005670_abnormal_white_adipose0.81842283
57MP0000566_synostosis0.81833901
58MP0001324_abnormal_eye_pigmentation0.81022359
59MP0002876_abnormal_thyroid_physiology0.80955138
60MP0001756_abnormal_urination0.78960863
61MP0005376_homeostasis/metabolism_phenot0.76824012
62MP0003646_muscle_fatigue0.76761266
63MP0000371_diluted_coat_color0.74919482
64MP0009765_abnormal_xenobiotic_induced0.74186883
65MP0001661_extended_life_span0.72292932
66MP0005075_abnormal_melanosome_morpholog0.71826674
67MP0005535_abnormal_body_temperature0.71077399
68MP0005334_abnormal_fat_pad0.70538122
69MP0002971_abnormal_brown_adipose0.70090802
70MP0003890_abnormal_embryonic-extraembry0.68844456
71MP0001986_abnormal_taste_sensitivity0.67402702
72MP0000639_abnormal_adrenal_gland0.64790650
73MP0005448_abnormal_energy_balance0.63305525
74MP0005266_abnormal_metabolism0.62699049
75MP0004130_abnormal_muscle_cell0.61269826
76MP0003329_amyloid_beta_deposits0.60326565
77MP0002928_abnormal_bile_duct0.59532493
78MP0003172_abnormal_lysosome_physiology0.58478690
79MP0009053_abnormal_anal_canal0.57646814
80MP0006035_abnormal_mitochondrial_morpho0.56208659
81MP0005187_abnormal_penis_morphology0.54700080
82MP0002282_abnormal_trachea_morphology0.54382228
83MP0002837_dystrophic_cardiac_calcinosis0.54295793
84MP0003690_abnormal_glial_cell0.53325323
85MP0005395_other_phenotype0.53077932
86MP0003953_abnormal_hormone_level0.52623336
87MP0001944_abnormal_pancreas_morphology0.52001163
88MP0004272_abnormal_basement_membrane0.51484247
89MP0002136_abnormal_kidney_physiology0.51003335
90MP0003638_abnormal_response/metabolism_0.49788664
91MP0002090_abnormal_vision0.49490294
92MP0003718_maternal_effect0.48550350
93MP0003123_paternal_imprinting0.48477250
94MP0004043_abnormal_pH_regulation0.47729830
95MP0002075_abnormal_coat/hair_pigmentati0.46893783
96MP0004264_abnormal_extraembryonic_tissu0.46244183
97MP0005464_abnormal_platelet_physiology0.45366039
98MP0005410_abnormal_fertilization0.44799081
99MP0009672_abnormal_birth_weight0.42978537
100MP0004782_abnormal_surfactant_physiolog0.42034072
101MP0005551_abnormal_eye_electrophysiolog0.40135432
102MP0005058_abnormal_lysosome_morphology0.39784664
103MP0008873_increased_physiological_sensi0.38361634
104MP0005164_abnormal_response_to0.37913994
105MP0005666_abnormal_adipose_tissue0.36982977
106MP0000230_abnormal_systemic_arterial0.36493703
107MP0002168_other_aberrant_phenotype0.36146331
108MP0000920_abnormal_myelination0.35620837
109MP0001186_pigmentation_phenotype0.35389249
110MP0002249_abnormal_larynx_morphology0.35352429
111MP0003959_abnormal_lean_body0.35248250
112MP0003941_abnormal_skin_development0.35126549
113MP0002822_catalepsy0.34903675
114MP0002653_abnormal_ependyma_morphology0.34715620
115MP0003699_abnormal_female_reproductive0.34483588
116MP0002796_impaired_skin_barrier0.34394916
117MP0002693_abnormal_pancreas_physiology0.34118221
118MP0002970_abnormal_white_adipose0.33026171
119MP0008874_decreased_physiological_sensi0.32856323
120MP0003724_increased_susceptibility_to0.32649053
121MP0005248_abnormal_Harderian_gland0.31678655
122MP0003632_abnormal_nervous_system0.31382158
123MP0001765_abnormal_ion_homeostasis0.31230833
124MP0003075_altered_response_to0.30951359
125MP0006292_abnormal_olfactory_placode0.30751233
126MP0000579_abnormal_nail_morphology0.30485500
127MP0003436_decreased_susceptibility_to0.30287131
128MP0001243_abnormal_dermal_layer0.30274755
129MP0003567_abnormal_fetal_cardiomyocyte0.30234516
130MP0005646_abnormal_pituitary_gland0.29957167
131MP0005409_darkened_coat_color0.29581358
132MP0005023_abnormal_wound_healing0.29397908
133MP0008872_abnormal_physiological_respon0.28516611
134MP0009115_abnormal_fat_cell0.28132869
135MP0005166_decreased_susceptibility_to0.28069179
136MP0009384_cardiac_valve_regurgitation0.28044391
137MP0004381_abnormal_hair_follicle0.26587576
138MP0000249_abnormal_blood_vessel0.24928225
139MP0001881_abnormal_mammary_gland0.24898930
140* MP0001845_abnormal_inflammatory_respons0.24515011

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.51742446
2Deep venous thrombosis (HP:0002625)7.15674385
3Intrahepatic cholestasis (HP:0001406)7.12279516
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.52466508
5Prolonged partial thromboplastin time (HP:0003645)6.40731819
6Hypobetalipoproteinemia (HP:0003563)6.22236391
7Xanthomatosis (HP:0000991)6.16000184
8Hyperlipoproteinemia (HP:0010980)5.41628191
9Complement deficiency (HP:0004431)5.12003175
10Hypolipoproteinemia (HP:0010981)4.71469023
11Joint hemorrhage (HP:0005261)4.64204474
12Abnormality of the common coagulation pathway (HP:0010990)4.54702573
13Hyperammonemia (HP:0001987)4.52747804
14Hyperglycinemia (HP:0002154)4.47172620
15Ketosis (HP:0001946)4.45884751
16Hypoglycemic coma (HP:0001325)4.44371363
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27575205
18Epidermoid cyst (HP:0200040)4.27378092
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.20848718
20Hypoalphalipoproteinemia (HP:0003233)4.16813406
21Abnormality of methionine metabolism (HP:0010901)4.16599464
22Fat malabsorption (HP:0002630)4.16077603
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.03988060
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01198842
25Hyperglycinuria (HP:0003108)3.99719694
26Abnormality of the intrinsic pathway (HP:0010989)3.99467153
27Abnormality of serine family amino acid metabolism (HP:0010894)3.94861574
28Abnormality of glycine metabolism (HP:0010895)3.94861574
29Conjugated hyperbilirubinemia (HP:0002908)3.81618637
30Abnormality of complement system (HP:0005339)3.71893046
31Abnormality of pyrimidine metabolism (HP:0004353)3.65572748
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43073998
33Hypercholesterolemia (HP:0003124)3.43032114
34Abnormality of fatty-acid metabolism (HP:0004359)3.42513381
35Ketoacidosis (HP:0001993)3.40814684
36Hyperbilirubinemia (HP:0002904)3.32669146
37Nephritis (HP:0000123)3.22065505
38Steatorrhea (HP:0002570)3.14686257
39Hypoglycemic seizures (HP:0002173)3.10234236
40Abnormality of nucleobase metabolism (HP:0010932)3.08691063
41Abnormality of serum amino acid levels (HP:0003112)3.03601531
42Delayed CNS myelination (HP:0002188)3.03330668
43Spontaneous abortion (HP:0005268)2.97073139
44Hepatocellular carcinoma (HP:0001402)2.92057285
45Gout (HP:0001997)2.87280862
46Purpura (HP:0000979)2.86795432
47Myocardial infarction (HP:0001658)2.84890651
48Hypochromic microcytic anemia (HP:0004840)2.83826855
49Abnormality of purine metabolism (HP:0004352)2.80250220
50Metabolic acidosis (HP:0001942)2.79092812
51Osteomalacia (HP:0002749)2.77241180
52Skin nodule (HP:0200036)2.74805682
53Hyperinsulinemic hypoglycemia (HP:0000825)2.68409603
54Dicarboxylic aciduria (HP:0003215)2.68284119
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68284119
56Lethargy (HP:0001254)2.61975545
57Systemic lupus erythematosus (HP:0002725)2.59181249
58Vascular calcification (HP:0004934)2.51935919
59Late onset (HP:0003584)2.49661600
60Acanthocytosis (HP:0001927)2.45984502
61Irritability (HP:0000737)2.45672243
62Abnormal gallbladder morphology (HP:0012437)2.42934925
63Pulmonary embolism (HP:0002204)2.36898970
64Generalized aminoaciduria (HP:0002909)2.36673268
65Cerebral edema (HP:0002181)2.36088344
66Mitral stenosis (HP:0001718)2.35487442
67Glomerulonephritis (HP:0000099)2.32607860
68Spastic diplegia (HP:0001264)2.32588621
69Cholelithiasis (HP:0001081)2.30515721
70Pancreatitis (HP:0001733)2.25489832
71Neonatal onset (HP:0003623)2.24083578
72Malnutrition (HP:0004395)2.23971083
73Enlarged kidneys (HP:0000105)2.23673153
74Amyloidosis (HP:0011034)2.23062546
75Hyperglycemia (HP:0003074)2.22779260
76Cardiovascular calcification (HP:0011915)2.21443953
77Brushfield spots (HP:0001088)2.20948146
78Cholecystitis (HP:0001082)2.20086718
79Abnormal gallbladder physiology (HP:0012438)2.20086718
80Abnormal delivery (HP:0001787)2.19384198
81Symptomatic seizures (HP:0011145)2.17683627
82Esophageal varix (HP:0002040)2.16503302
83Arthropathy (HP:0003040)2.15363924
84Recurrent gram-negative bacterial infections (HP:0005420)2.14874447
85Gingival bleeding (HP:0000225)2.10576555
86Vomiting (HP:0002013)2.09752594
87Menorrhagia (HP:0000132)2.09699820
88Joint swelling (HP:0001386)2.08830668
89Sensorimotor neuropathy (HP:0007141)2.07438301
90Opisthotonus (HP:0002179)2.04635082
91Hypophosphatemic rickets (HP:0004912)2.02729289
92Abnormality of the Achilles tendon (HP:0005109)2.02429501
93Thrombophlebitis (HP:0004418)2.01988745
94Epistaxis (HP:0000421)2.01757487
95Rickets (HP:0002748)1.98858229
96Abnormality of the gallbladder (HP:0005264)1.96603566
97Potter facies (HP:0002009)1.96547231
98Facial shape deformation (HP:0011334)1.96547231
99Reduced antithrombin III activity (HP:0001976)1.94963442
100Proximal tubulopathy (HP:0000114)1.93996780
101Poikilocytosis (HP:0004447)1.93539184
102Alkalosis (HP:0001948)1.93396889
103Hemorrhage of the eye (HP:0011885)1.91598072
104Increased serum pyruvate (HP:0003542)1.89744817
105Abnormal enzyme/coenzyme activity (HP:0012379)1.89041288
106Hyperalaninemia (HP:0003348)1.88594459
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88594459
108Abnormality of alanine metabolism (HP:0010916)1.88594459
109Fair hair (HP:0002286)1.88296397
110Renal cortical cysts (HP:0000803)1.88133079
111Abnormal cartilage morphology (HP:0002763)1.88000537
112Retinal atrophy (HP:0001105)1.87702338
113Abnormality of endocrine pancreas physiology (HP:0012093)1.86471124
114Abnormality of the pancreatic islet cells (HP:0006476)1.86471124
115Hyperphosphaturia (HP:0003109)1.86165911
116Abnormality of transition element cation homeostasis (HP:0011030)1.85732197
117Hyperuricemia (HP:0002149)1.85484634
118Increased purine levels (HP:0004368)1.85484634
119Gangrene (HP:0100758)1.84252848
120Elevated alkaline phosphatase (HP:0003155)1.83648150
121Abnormality of urine glucose concentration (HP:0011016)1.82474161
122Glycosuria (HP:0003076)1.82474161
123Abnormality of alkaline phosphatase activity (HP:0004379)1.80602190
124Blue irides (HP:0000635)1.79125726
125Abnormal tarsal ossification (HP:0008369)1.77463158
126Pancreatic islet-cell hyperplasia (HP:0004510)1.71949468
127Abnormality of glycolysis (HP:0004366)1.64680736
128Pigmentary retinal degeneration (HP:0001146)1.63726887
129Increased serum ferritin (HP:0003281)1.59279261
130Abnormality of carpal bone ossification (HP:0006257)1.59121706
131Abnormality of iron homeostasis (HP:0011031)1.57582758
132Abnormality of vitamin metabolism (HP:0100508)1.53374192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.39878653
2PDK25.24694134
3ERN14.70163286
4FGFR44.38057927
5SIK14.18136254
6INSRR3.91901597
7TAOK33.43970365
8LATS23.42741026
9ERBB42.65723673
10ACVR1B2.34904988
11PIK3CG2.33969280
12MAPK152.32966061
13FLT32.08146283
14PKN22.06232327
15PIK3CA2.00873186
16MST1R1.97999917
17TRIB31.95167170
18MAP2K41.90344826
19NLK1.85554078
20STK381.79632087
21MAPK111.76738918
22PBK1.70845273
23FRK1.67534048
24PTK61.55246524
25ZAK1.54604433
26LATS11.48864198
27TYK21.47016556
28EIF2AK31.44108450
29DAPK21.33040591
30ABL21.31757548
31NEK91.30342338
32MELK1.20570287
33EPHA41.19957162
34KDR1.18519235
35LMTK21.17005812
36NTRK31.15689489
37PINK11.15039406
38JAK21.13197512
39FGFR11.09990026
40WNK31.09005258
41STK38L1.02844277
42PRKAA21.01952205
43IRAK30.99294474
44MET0.96479391
45MAP3K30.95962511
46BMPR1B0.94415409
47FGFR20.93469472
48TESK20.92328824
49ERBB20.90308935
50DYRK1B0.89520039
51EPHA30.88982918
52MAP3K70.88541160
53MAP2K30.87876397
54FGR0.87188103
55TBK10.83921487
56PRKCZ0.82963303
57JAK10.82956970
58CSNK1D0.79369134
59GRK60.78037614
60MAP3K110.76184782
61MAP3K100.75860802
62TYRO30.75639680
63PTK20.73767338
64PRKACG0.72888445
65MAPK40.72573562
66PRKAA10.71515015
67PRKD30.71237387
68EPHB10.70513012
69NEK20.69362117
70GSK3A0.69257936
71MAP2K20.67282926
72STK30.65637720
73MAP3K140.65568891
74CSK0.65410965
75TIE10.65367908
76CDK60.64876680
77FER0.61646016
78CAMK2G0.60921782
79CDK70.60078811
80PRKACB0.59737096
81EIF2AK10.59242359
82NEK10.58909504
83MAP2K60.58269931
84RIPK10.57319034
85CSNK1E0.56011313
86MAPK120.55449384
87BRSK10.53578479
88CSNK2A10.52332867
89PRKACA0.52190225
90RPS6KB10.52039738
91MAP2K10.52012413
92MAP3K10.51681561
93SGK30.50846252
94EPHA20.50447537
95WNK40.50305145
96CSNK2A20.49980022
97CAMK1D0.49254769
98PDPK10.48660353
99MTOR0.48310029
100MAP3K20.48113704
101PRKG10.47123917
102PRKCB0.46537713
103STK390.46227139
104WEE10.44287562
105IRAK10.44214267
106MAPK70.43210782
107CSNK1G10.42749696
108SGK10.42179368
109AKT20.39795451
110IGF1R0.39362320
111FGFR30.38404368
112RET0.37764219
113CDK40.37629113
114GRK10.37418890
115PRKCG0.37180664
116CDK120.36682417
117AKT30.36490455
118SGK20.36383608
119MAP3K50.35975853
120TGFBR20.35337010
121CSNK1A10.35231945
122SGK2230.32721020
123SGK4940.32721020
124PAK30.32503075
125PRKCQ0.32425646
126CDK90.32256693
127PRKD10.31127694
128MAPKAPK30.29829572
129TAOK20.29159541
130IKBKE0.28769281
131PDK40.28753232
132PDK30.28753232
133RPS6KA30.27219437
134IRAK20.27184054
135MATK0.26832677
136ICK0.24962463
137PRKCA0.24673872
138EGFR0.24646322
139PDK10.23593155
140PDGFRA0.23117692
141ZAP700.22908676
142CSF1R0.20540413
143CSNK1G20.18526471
144CSNK1G30.18375880
145MAPK30.17820673
146STK160.17162703

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38818170
2Nitrogen metabolism_Homo sapiens_hsa009103.50632305
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29658111
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27724257
5Arginine biosynthesis_Homo sapiens_hsa002202.97554285
6Complement and coagulation cascades_Homo sapiens_hsa046102.69865283
7Tryptophan metabolism_Homo sapiens_hsa003802.69346393
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65676277
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64229490
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60640490
11Fatty acid degradation_Homo sapiens_hsa000712.49982020
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45311288
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20885481
14Butanoate metabolism_Homo sapiens_hsa006502.18450406
15Peroxisome_Homo sapiens_hsa041462.07664457
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05630800
17Propanoate metabolism_Homo sapiens_hsa006401.95128981
18Histidine metabolism_Homo sapiens_hsa003401.89131156
19Chemical carcinogenesis_Homo sapiens_hsa052041.86623587
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83841002
21PPAR signaling pathway_Homo sapiens_hsa033201.82664949
22Fatty acid metabolism_Homo sapiens_hsa012121.81037379
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.80168922
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.75808296
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71537515
26beta-Alanine metabolism_Homo sapiens_hsa004101.70359327
27Selenocompound metabolism_Homo sapiens_hsa004501.69150267
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65829407
29Staphylococcus aureus infection_Homo sapiens_hsa051501.64686519
30Retinol metabolism_Homo sapiens_hsa008301.61547023
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.60611963
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59403726
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55916536
34Caffeine metabolism_Homo sapiens_hsa002321.54927290
35Phenylalanine metabolism_Homo sapiens_hsa003601.53371406
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52001865
37Sulfur metabolism_Homo sapiens_hsa009201.49976863
38Bile secretion_Homo sapiens_hsa049761.45195596
39Tyrosine metabolism_Homo sapiens_hsa003501.40668344
40Folate biosynthesis_Homo sapiens_hsa007901.39492546
41Pyruvate metabolism_Homo sapiens_hsa006201.38439327
42Fat digestion and absorption_Homo sapiens_hsa049751.37083570
43Fatty acid elongation_Homo sapiens_hsa000621.33978657
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.31514675
45Starch and sucrose metabolism_Homo sapiens_hsa005001.28679689
46Steroid biosynthesis_Homo sapiens_hsa001001.23392400
47ABC transporters_Homo sapiens_hsa020101.21472533
48Biosynthesis of amino acids_Homo sapiens_hsa012301.20135415
49Carbon metabolism_Homo sapiens_hsa012001.13888107
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.04085786
51Arginine and proline metabolism_Homo sapiens_hsa003301.00973342
52Vitamin B6 metabolism_Homo sapiens_hsa007501.00790382
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97616226
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96507645
55Sulfur relay system_Homo sapiens_hsa041220.95638641
56Vitamin digestion and absorption_Homo sapiens_hsa049770.94197722
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84973187
58Lysine degradation_Homo sapiens_hsa003100.81623566
59One carbon pool by folate_Homo sapiens_hsa006700.80596965
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80583139
61Glycerolipid metabolism_Homo sapiens_hsa005610.75013830
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70479105
63Glutathione metabolism_Homo sapiens_hsa004800.67631255
64Pentose phosphate pathway_Homo sapiens_hsa000300.59980453
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58688658
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52073973
67Metabolic pathways_Homo sapiens_hsa011000.48985576
68Other glycan degradation_Homo sapiens_hsa005110.46582313
69Fatty acid biosynthesis_Homo sapiens_hsa000610.43014568
70Prion diseases_Homo sapiens_hsa050200.38406038
71Sphingolipid metabolism_Homo sapiens_hsa006000.38247208
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35576157
73Galactose metabolism_Homo sapiens_hsa000520.33536630
74Fructose and mannose metabolism_Homo sapiens_hsa000510.32112442
75N-Glycan biosynthesis_Homo sapiens_hsa005100.29809126
76Linoleic acid metabolism_Homo sapiens_hsa005910.29710049
77Pertussis_Homo sapiens_hsa051330.25382686
78Insulin resistance_Homo sapiens_hsa049310.25131218
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.20228647
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20071107
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.19788112
82Glucagon signaling pathway_Homo sapiens_hsa049220.14018540
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09656694
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05558131
85AMPK signaling pathway_Homo sapiens_hsa041520.03425518
86Regulation of autophagy_Homo sapiens_hsa041400.01535922
87Mineral absorption_Homo sapiens_hsa049780.00401583
88African trypanosomiasis_Homo sapiens_hsa05143-0.2110160
89Type II diabetes mellitus_Homo sapiens_hsa04930-0.1994116
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.1990846
91Hepatitis C_Homo sapiens_hsa05160-0.1922990
92Lysosome_Homo sapiens_hsa04142-0.1920105
93ECM-receptor interaction_Homo sapiens_hsa04512-0.1853695
94Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1819231
95Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1801759
96Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1708837
97Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1507511
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1442427
99Serotonergic synapse_Homo sapiens_hsa04726-0.1361563
100Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1325592
101Amoebiasis_Homo sapiens_hsa05146-0.1324275
102Protein digestion and absorption_Homo sapiens_hsa04974-0.1320829
103Ether lipid metabolism_Homo sapiens_hsa00565-0.1282215
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1152212
105Renin-angiotensin system_Homo sapiens_hsa04614-0.1080553
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0998869
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0946644
108Protein export_Homo sapiens_hsa03060-0.0838065
109Insulin signaling pathway_Homo sapiens_hsa04910-0.0811107
110Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0653170
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0284598
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0148439

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