

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.58717373 |
| 2 | L-phenylalanine catabolic process (GO:0006559) | 7.58717373 |
| 3 | exogenous drug catabolic process (GO:0042738) | 7.56510856 |
| 4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.23963654 |
| 5 | L-phenylalanine metabolic process (GO:0006558) | 7.23963654 |
| 6 | epoxygenase P450 pathway (GO:0019373) | 6.92193686 |
| 7 | omega-hydroxylase P450 pathway (GO:0097267) | 6.91804025 |
| 8 | aromatic amino acid family catabolic process (GO:0009074) | 6.86665167 |
| 9 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.26921649 |
| 10 | indole-containing compound catabolic process (GO:0042436) | 6.23562465 |
| 11 | indolalkylamine catabolic process (GO:0046218) | 6.23562465 |
| 12 | tryptophan catabolic process (GO:0006569) | 6.23562465 |
| 13 | kynurenine metabolic process (GO:0070189) | 6.09679956 |
| 14 | bile acid biosynthetic process (GO:0006699) | 6.00723170 |
| 15 | tryptophan metabolic process (GO:0006568) | 5.85778420 |
| 16 | glyoxylate metabolic process (GO:0046487) | 5.77219243 |
| 17 | urea cycle (GO:0000050) | 5.73411533 |
| 18 | urea metabolic process (GO:0019627) | 5.73411533 |
| 19 | negative regulation of fibrinolysis (GO:0051918) | 5.66645874 |
| 20 | alpha-linolenic acid metabolic process (GO:0036109) | 5.59962852 |
| 21 | high-density lipoprotein particle remodeling (GO:0034375) | 5.52771885 |
| 22 | complement activation, alternative pathway (GO:0006957) | 5.51724686 |
| 23 | oxidative demethylation (GO:0070989) | 5.48995163 |
| 24 | regulation of protein activation cascade (GO:2000257) | 5.48530481 |
| 25 | regulation of fibrinolysis (GO:0051917) | 5.47587409 |
| 26 | protein carboxylation (GO:0018214) | 5.43268861 |
| 27 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.43268861 |
| 28 | drug metabolic process (GO:0017144) | 5.37287648 |
| 29 | cysteine metabolic process (GO:0006534) | 5.32381741 |
| 30 | sulfur amino acid catabolic process (GO:0000098) | 5.31634287 |
| 31 | nitrogen cycle metabolic process (GO:0071941) | 5.26957239 |
| 32 | serine family amino acid catabolic process (GO:0009071) | 5.13249206 |
| 33 | regulation of complement activation (GO:0030449) | 5.12460215 |
| 34 | bile acid metabolic process (GO:0008206) | 5.11820209 |
| 35 | regulation of plasminogen activation (GO:0010755) | 5.04104133 |
| 36 | aromatic amino acid family metabolic process (GO:0009072) | 4.98048351 |
| 37 | phenylpropanoid metabolic process (GO:0009698) | 4.93168101 |
| 38 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.90693005 |
| 39 | regulation of triglyceride catabolic process (GO:0010896) | 4.84265508 |
| 40 | reverse cholesterol transport (GO:0043691) | 4.83659391 |
| 41 | tyrosine metabolic process (GO:0006570) | 4.82267485 |
| 42 | homocysteine metabolic process (GO:0050667) | 4.80503034 |
| 43 | regulation of cholesterol esterification (GO:0010872) | 4.79730983 |
| 44 | protein-lipid complex remodeling (GO:0034368) | 4.75191997 |
| 45 | macromolecular complex remodeling (GO:0034367) | 4.75191997 |
| 46 | plasma lipoprotein particle remodeling (GO:0034369) | 4.75191997 |
| 47 | alpha-amino acid catabolic process (GO:1901606) | 4.65711199 |
| 48 | triglyceride homeostasis (GO:0070328) | 4.62590577 |
| 49 | acylglycerol homeostasis (GO:0055090) | 4.62590577 |
| 50 | amino-acid betaine metabolic process (GO:0006577) | 4.60793723 |
| 51 | lysine metabolic process (GO:0006553) | 4.59951937 |
| 52 | lysine catabolic process (GO:0006554) | 4.59951937 |
| 53 | negative regulation of protein activation cascade (GO:2000258) | 4.58136383 |
| 54 | negative regulation of hemostasis (GO:1900047) | 4.54241273 |
| 55 | negative regulation of blood coagulation (GO:0030195) | 4.54241273 |
| 56 | ethanol metabolic process (GO:0006067) | 4.53503310 |
| 57 | phospholipid efflux (GO:0033700) | 4.51803356 |
| 58 | negative regulation of sterol transport (GO:0032372) | 4.48999036 |
| 59 | negative regulation of cholesterol transport (GO:0032375) | 4.48999036 |
| 60 | bile acid and bile salt transport (GO:0015721) | 4.44283183 |
| 61 | coenzyme catabolic process (GO:0009109) | 4.42749692 |
| 62 | glycine metabolic process (GO:0006544) | 4.42744929 |
| 63 | cellular ketone body metabolic process (GO:0046950) | 4.42078035 |
| 64 | indolalkylamine metabolic process (GO:0006586) | 4.41412671 |
| 65 | imidazole-containing compound metabolic process (GO:0052803) | 4.37521608 |
| 66 | plasma lipoprotein particle clearance (GO:0034381) | 4.36339583 |
| 67 | amine catabolic process (GO:0009310) | 4.32566326 |
| 68 | cellular biogenic amine catabolic process (GO:0042402) | 4.32566326 |
| 69 | cellular amino acid catabolic process (GO:0009063) | 4.27683667 |
| 70 | S-adenosylmethionine metabolic process (GO:0046500) | 4.26454709 |
| 71 | glutamate metabolic process (GO:0006536) | 4.24325836 |
| 72 | cellular glucuronidation (GO:0052695) | 4.23155641 |
| 73 | cholesterol efflux (GO:0033344) | 4.20844676 |
| 74 | serine family amino acid metabolic process (GO:0009069) | 4.16791789 |
| 75 | flavonoid metabolic process (GO:0009812) | 4.14946061 |
| 76 | negative regulation of coagulation (GO:0050819) | 4.13841672 |
| 77 | alkaloid metabolic process (GO:0009820) | 4.13133823 |
| 78 | intestinal cholesterol absorption (GO:0030299) | 4.12931474 |
| 79 | benzene-containing compound metabolic process (GO:0042537) | 4.12046587 |
| 80 | negative regulation of wound healing (GO:0061045) | 4.07529987 |
| 81 | ethanol oxidation (GO:0006069) | 4.07377537 |
| 82 | dicarboxylic acid biosynthetic process (GO:0043650) | 4.06802866 |
| 83 | regulation of humoral immune response (GO:0002920) | 4.06408841 |
| 84 | fibrinolysis (GO:0042730) | 4.06270724 |
| 85 | cellular modified amino acid catabolic process (GO:0042219) | 4.04897582 |
| 86 | arginine metabolic process (GO:0006525) | 4.02755610 |
| 87 | serine family amino acid biosynthetic process (GO:0009070) | 3.99499536 |
| 88 | low-density lipoprotein particle remodeling (GO:0034374) | 3.99409794 |
| 89 | negative regulation of complement activation (GO:0045916) | 3.98136979 |
| 90 | plasma lipoprotein particle assembly (GO:0034377) | 3.96614500 |
| 91 | positive regulation of blood coagulation (GO:0030194) | 3.95915514 |
| 92 | positive regulation of hemostasis (GO:1900048) | 3.95915514 |
| 93 | aldehyde catabolic process (GO:0046185) | 3.95194685 |
| 94 | blood coagulation, intrinsic pathway (GO:0007597) | 3.89617598 |
| 95 | complement activation, classical pathway (GO:0006958) | 3.86107147 |
| 96 | drug catabolic process (GO:0042737) | 3.84006396 |
| 97 | ketone body metabolic process (GO:1902224) | 3.82609115 |
| 98 | complement activation (GO:0006956) | 3.81594974 |
| 99 | steroid catabolic process (GO:0006706) | 3.80618552 |
| 100 | cofactor catabolic process (GO:0051187) | 3.80254373 |
| 101 | protein activation cascade (GO:0072376) | 3.79312047 |
| 102 | cytolysis (GO:0019835) | 3.79278693 |
| 103 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.76908391 |
| 104 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.76908391 |
| 105 | phospholipid homeostasis (GO:0055091) | 3.76329698 |
| 106 | glucuronate metabolic process (GO:0019585) | 3.75188097 |
| 107 | uronic acid metabolic process (GO:0006063) | 3.75188097 |
| 108 | regulation of bile acid biosynthetic process (GO:0070857) | 3.74392918 |
| 109 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.74210091 |
| 110 | organic acid catabolic process (GO:0016054) | 3.74032815 |
| 111 | carboxylic acid catabolic process (GO:0046395) | 3.74032815 |
| 112 | cholesterol homeostasis (GO:0042632) | 3.73293913 |
| 113 | positive regulation of lipid catabolic process (GO:0050996) | 3.73108015 |
| 114 | negative regulation of lipase activity (GO:0060192) | 3.71909682 |
| 115 | acetyl-CoA metabolic process (GO:0006084) | 3.70368869 |
| 116 | sterol homeostasis (GO:0055092) | 3.67009695 |
| 117 | regulation of cholesterol homeostasis (GO:2000188) | 3.65701372 |
| 118 | positive regulation of coagulation (GO:0050820) | 3.64713100 |
| 119 | short-chain fatty acid metabolic process (GO:0046459) | 3.62533687 |
| 120 | plasma lipoprotein particle organization (GO:0071827) | 3.60946739 |
| 121 | NAD biosynthetic process (GO:0009435) | 3.58065034 |
| 122 | heme transport (GO:0015886) | 3.57308594 |
| 123 | protein-lipid complex assembly (GO:0065005) | 3.55019961 |
| 124 | acute-phase response (GO:0006953) | 3.54177744 |
| 125 | xenobiotic metabolic process (GO:0006805) | 3.51141063 |
| 126 | amino acid salvage (GO:0043102) | 3.44542680 |
| 127 | L-methionine salvage (GO:0071267) | 3.44542680 |
| 128 | L-methionine biosynthetic process (GO:0071265) | 3.44542680 |
| 129 | drug transmembrane transport (GO:0006855) | 3.37940817 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.39641746 |
| 2 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.19605987 |
| 3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 7.05384424 |
| 4 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.49676344 |
| 5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.33211823 |
| 6 | * CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 5.05573803 |
| 7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.84305360 |
| 8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 4.09579101 |
| 9 | * CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.90233937 |
| 10 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.91270932 |
| 11 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.24393629 |
| 12 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.08806058 |
| 13 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.07588340 |
| 14 | VDR_22108803_ChIP-Seq_LS180_Human | 2.01402725 |
| 15 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 12.0062402 |
| 16 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.97967762 |
| 17 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.96524321 |
| 18 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.95923939 |
| 19 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.89217580 |
| 20 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.79955400 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.69821755 |
| 22 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.62038432 |
| 23 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.61937117 |
| 24 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.59280525 |
| 25 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.57546222 |
| 26 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.55553821 |
| 27 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.54248551 |
| 28 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.51962213 |
| 29 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.51595042 |
| 30 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.47320869 |
| 31 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.45866010 |
| 32 | GATA1_22025678_ChIP-Seq_K562_Human | 1.44122539 |
| 33 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.42343829 |
| 34 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.40029842 |
| 35 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.37517650 |
| 36 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.37009578 |
| 37 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.36390069 |
| 38 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.29987394 |
| 39 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.27488198 |
| 40 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.27308266 |
| 41 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.26864549 |
| 42 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.26864549 |
| 43 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.26531349 |
| 44 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.26428616 |
| 45 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.26418018 |
| 46 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.26150547 |
| 47 | P300_19829295_ChIP-Seq_ESCs_Human | 1.24758725 |
| 48 | AR_25329375_ChIP-Seq_VCAP_Human | 1.22440176 |
| 49 | TCF4_23295773_ChIP-Seq_U87_Human | 1.22439148 |
| 50 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.22402272 |
| 51 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.20360354 |
| 52 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.19988262 |
| 53 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.19699817 |
| 54 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.18851342 |
| 55 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.18510456 |
| 56 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.18190379 |
| 57 | * RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.17333954 |
| 58 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.16061271 |
| 59 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.13245876 |
| 60 | * TP53_18474530_ChIP-ChIP_U2OS_Human | 1.12804940 |
| 61 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.11030847 |
| 62 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.09159608 |
| 63 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.08756802 |
| 64 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.06476672 |
| 65 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.05931165 |
| 66 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.05810665 |
| 67 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.05317923 |
| 68 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.03961166 |
| 69 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.02722763 |
| 70 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.02722763 |
| 71 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.02615574 |
| 72 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.01981963 |
| 73 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.01763281 |
| 74 | FUS_26573619_Chip-Seq_HEK293_Human | 1.01601393 |
| 75 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.01184068 |
| 76 | TP53_16413492_ChIP-PET_HCT116_Human | 1.01139257 |
| 77 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.00137371 |
| 78 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.00105693 |
| 79 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.99357159 |
| 80 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.99268470 |
| 81 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.99028094 |
| 82 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.98910118 |
| 83 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.96922378 |
| 84 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.96922378 |
| 85 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.96581679 |
| 86 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.96528095 |
| 87 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.94608003 |
| 88 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.94398138 |
| 89 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.94374434 |
| 90 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.93954223 |
| 91 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.93800472 |
| 92 | NFYA_21822215_ChIP-Seq_K562_Human | 0.93605748 |
| 93 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.93168140 |
| 94 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.92434973 |
| 95 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.90813746 |
| 96 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.88415098 |
| 97 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.86149627 |
| 98 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.84375744 |
| 99 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.84050124 |
| 100 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.83446066 |
| 101 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.80929440 |
| 102 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.78665047 |
| 103 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.78606796 |
| 104 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.77420367 |
| 105 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.76404248 |
| 106 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.75856694 |
| 107 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.73777379 |
| 108 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.72083012 |
| 109 | * RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.70385322 |
| 110 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.70351929 |
| 111 | * SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.69559567 |
| 112 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.66894766 |
| 113 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.65843873 |
| 114 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.65784884 |
| 115 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.65784884 |
| 116 | * AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.65431713 |
| 117 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.63674329 |
| 118 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.62744232 |
| 119 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.59694477 |
| 120 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.59523836 |
| 121 | * RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.59201557 |
| 122 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.58405106 |
| 123 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.57309625 |
| 124 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.54481419 |
| 125 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.54367492 |
| 126 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.53599197 |
| 127 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.51928163 |
| 128 | AR_20517297_ChIP-Seq_VCAP_Human | 0.51886334 |
| 129 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.51200607 |
| 130 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.50303624 |
| 131 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.49562834 |
| 132 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.48782040 |
| 133 | CBP_21632823_ChIP-Seq_H3396_Human | 0.48497457 |
| 134 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.48362575 |
| 135 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.48182130 |
| 136 | * FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.48164515 |
| 137 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.45954563 |
| 138 | * STAT1_17558387_ChIP-Seq_HELA_Human | 0.45334421 |
| 139 | * PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.45329879 |
| 140 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.45042141 |
| 141 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.44385893 |
| 142 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.44220597 |
| 143 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.43621110 |
| 144 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.43184464 |
| 145 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.42799150 |
| 146 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.42570513 |
| 147 | GATA1_19941826_ChIP-Seq_K562_Human | 0.42333102 |
| 148 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.42206734 |
| 149 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.41928046 |
| 150 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.41578283 |
| 151 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.40801475 |
| 152 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.40688577 |
| 153 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.40533733 |
| 154 | GATA2_19941826_ChIP-Seq_K562_Human | 0.40306214 |
| 155 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.39957967 |
| 156 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.39880249 |
| 157 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.38267050 |
| 158 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.38213581 |
| 159 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.37170789 |
| 160 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.36864039 |
| 161 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.36498140 |
| 162 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 0.35276076 |
| 163 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.34569845 |
| 164 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.34423973 |
| 165 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.33583401 |
| 166 | NCOR_22424771_ChIP-Seq_293T_Human | 0.33505247 |
| 167 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.33138186 |
| 168 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.32921618 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 8.27446089 |
| 2 | MP0005360_urolithiasis | 7.57043895 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 6.48343126 |
| 4 | MP0005365_abnormal_bile_salt | 6.18941363 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 5.08083520 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 4.25063815 |
| 7 | MP0003252_abnormal_bile_duct | 3.92720363 |
| 8 | MP0010329_abnormal_lipoprotein_level | 3.60073872 |
| 9 | MP0009840_abnormal_foam_cell | 3.25142203 |
| 10 | MP0005083_abnormal_biliary_tract | 3.11352021 |
| 11 | MP0003195_calcinosis | 2.83403073 |
| 12 | MP0005332_abnormal_amino_acid | 2.75155691 |
| 13 | MP0001666_abnormal_nutrient_absorption | 2.59350763 |
| 14 | MP0003191_abnormal_cellular_cholesterol | 2.35459451 |
| 15 | MP0000609_abnormal_liver_physiology | 2.17353596 |
| 16 | MP0002118_abnormal_lipid_homeostasis | 2.11045257 |
| 17 | MP0004019_abnormal_vitamin_homeostasis | 2.10783484 |
| 18 | MP0002138_abnormal_hepatobiliary_system | 1.95349114 |
| 19 | MP0003868_abnormal_feces_composition | 1.94677383 |
| 20 | MP0005319_abnormal_enzyme/_coenzyme | 1.83426164 |
| 21 | MP0001764_abnormal_homeostasis | 1.65847389 |
| 22 | MP0009697_abnormal_copulation | 1.60281878 |
| 23 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.56681830 |
| 24 | MP0005451_abnormal_body_composition | 1.41454658 |
| 25 | MP0003011_delayed_dark_adaptation | 1.38996614 |
| 26 | MP0003656_abnormal_erythrocyte_physiolo | 1.26871954 |
| 27 | MP0003186_abnormal_redox_activity | 1.24356513 |
| 28 | MP0009643_abnormal_urine_homeostasis | 1.20965883 |
| 29 | MP0000598_abnormal_liver_morphology | 1.17857370 |
| 30 | MP0003705_abnormal_hypodermis_morpholog | 1.16912782 |
| 31 | MP0005647_abnormal_sex_gland | 1.16349993 |
| 32 | MP0000604_amyloidosis | 1.07200720 |
| 33 | MP0009764_decreased_sensitivity_to | 1.06997587 |
| 34 | MP0005551_abnormal_eye_electrophysiolog | 1.05102290 |
| 35 | MP0009763_increased_sensitivity_to | 1.03113937 |
| 36 | MP0002254_reproductive_system_inflammat | 1.02724353 |
| 37 | MP0010368_abnormal_lymphatic_system | 0.99924640 |
| 38 | MP0005187_abnormal_penis_morphology | 0.94165122 |
| 39 | MP0005636_abnormal_mineral_homeostasis | 0.90994590 |
| 40 | MP0008469_abnormal_protein_level | 0.89742877 |
| 41 | MP0005670_abnormal_white_adipose | 0.87236524 |
| 42 | MP0009642_abnormal_blood_homeostasis | 0.87036484 |
| 43 | MP0005408_hypopigmentation | 0.84449902 |
| 44 | MP0006036_abnormal_mitochondrial_physio | 0.82097641 |
| 45 | MP0005646_abnormal_pituitary_gland | 0.80792672 |
| 46 | MP0001986_abnormal_taste_sensitivity | 0.79794300 |
| 47 | MP0005376_homeostasis/metabolism_phenot | 0.79686963 |
| 48 | MP0004043_abnormal_pH_regulation | 0.79099073 |
| 49 | MP0009765_abnormal_xenobiotic_induced | 0.78228553 |
| 50 | MP0002078_abnormal_glucose_homeostasis | 0.78206494 |
| 51 | MP0005084_abnormal_gallbladder_morpholo | 0.77938387 |
| 52 | MP0002876_abnormal_thyroid_physiology | 0.77680687 |
| 53 | MP0003183_abnormal_peptide_metabolism | 0.76289610 |
| 54 | MP0002971_abnormal_brown_adipose | 0.74799636 |
| 55 | MP0005220_abnormal_exocrine_pancreas | 0.73585327 |
| 56 | MP0004130_abnormal_muscle_cell | 0.72308126 |
| 57 | MP0005334_abnormal_fat_pad | 0.70015300 |
| 58 | MP0005535_abnormal_body_temperature | 0.68955149 |
| 59 | MP0001661_extended_life_span | 0.68737990 |
| 60 | MP0003690_abnormal_glial_cell | 0.67667857 |
| 61 | MP0005266_abnormal_metabolism | 0.64539940 |
| 62 | MP0009053_abnormal_anal_canal | 0.63706478 |
| 63 | MP0002282_abnormal_trachea_morphology | 0.63083943 |
| 64 | MP0002736_abnormal_nociception_after | 0.61799611 |
| 65 | MP0003329_amyloid_beta_deposits | 0.60776219 |
| 66 | MP0000639_abnormal_adrenal_gland | 0.60390819 |
| 67 | MP0006035_abnormal_mitochondrial_morpho | 0.58007743 |
| 68 | MP0001756_abnormal_urination | 0.56916431 |
| 69 | MP0005448_abnormal_energy_balance | 0.56832960 |
| 70 | MP0005464_abnormal_platelet_physiology | 0.54407409 |
| 71 | MP0000371_diluted_coat_color | 0.53198265 |
| 72 | MP0001915_intracranial_hemorrhage | 0.49781793 |
| 73 | MP0003879_abnormal_hair_cell | 0.49542139 |
| 74 | MP0002822_catalepsy | 0.49264738 |
| 75 | MP0005377_hearing/vestibular/ear_phenot | 0.49019832 |
| 76 | MP0003878_abnormal_ear_physiology | 0.49019832 |
| 77 | MP0005395_other_phenotype | 0.48696826 |
| 78 | MP0005410_abnormal_fertilization | 0.48435609 |
| 79 | MP0001501_abnormal_sleep_pattern | 0.47100883 |
| 80 | MP0010386_abnormal_urinary_bladder | 0.47054487 |
| 81 | MP0002090_abnormal_vision | 0.46877798 |
| 82 | MP0002928_abnormal_bile_duct | 0.46458792 |
| 83 | MP0003724_increased_susceptibility_to | 0.46164026 |
| 84 | MP0009745_abnormal_behavioral_response | 0.45958390 |
| 85 | MP0003718_maternal_effect | 0.45817439 |
| 86 | MP0004381_abnormal_hair_follicle | 0.45475170 |
| 87 | MP0004782_abnormal_surfactant_physiolog | 0.45297814 |
| 88 | MP0003638_abnormal_response/metabolism_ | 0.45078241 |
| 89 | MP0008874_decreased_physiological_sensi | 0.44813267 |
| 90 | MP0003950_abnormal_plasma_membrane | 0.44733222 |
| 91 | MP0003436_decreased_susceptibility_to | 0.44481216 |
| 92 | MP0002837_dystrophic_cardiac_calcinosis | 0.44480055 |
| 93 | MP0008873_increased_physiological_sensi | 0.43440835 |
| 94 | MP0002136_abnormal_kidney_physiology | 0.43119211 |
| 95 | MP0005167_abnormal_blood-brain_barrier | 0.42974408 |
| 96 | MP0001968_abnormal_touch/_nociception | 0.42928195 |
| 97 | MP0001984_abnormal_olfaction | 0.42770626 |
| 98 | MP0000569_abnormal_digit_pigmentation | 0.42742694 |
| 99 | MP0001324_abnormal_eye_pigmentation | 0.42103919 |
| 100 | MP0002234_abnormal_pharynx_morphology | 0.41995987 |
| 101 | MP0005248_abnormal_Harderian_gland | 0.40637271 |
| 102 | MP0003953_abnormal_hormone_level | 0.40418651 |
| 103 | MP0003122_maternal_imprinting | 0.40302034 |
| 104 | MP0005666_abnormal_adipose_tissue | 0.40203743 |
| 105 | MP0003075_altered_response_to | 0.40084861 |
| 106 | MP0003633_abnormal_nervous_system | 0.39950379 |
| 107 | MP0005253_abnormal_eye_physiology | 0.38905824 |
| 108 | MP0005166_decreased_susceptibility_to | 0.38840733 |
| 109 | MP0000579_abnormal_nail_morphology | 0.38372135 |
| 110 | MP0004142_abnormal_muscle_tone | 0.38263501 |
| 111 | MP0008872_abnormal_physiological_respon | 0.36475273 |
| 112 | MP0009672_abnormal_birth_weight | 0.35967543 |
| 113 | MP0006292_abnormal_olfactory_placode | 0.35913676 |
| 114 | MP0009384_cardiac_valve_regurgitation | 0.35365012 |
| 115 | MP0009115_abnormal_fat_cell | 0.34203059 |
| 116 | MP0000249_abnormal_blood_vessel | 0.32544961 |
| 117 | MP0002796_impaired_skin_barrier | 0.32496479 |
| 118 | MP0004883_abnormal_blood_vessel | 0.32493571 |
| 119 | MP0001853_heart_inflammation | 0.32337371 |
| 120 | MP0002970_abnormal_white_adipose | 0.31708685 |
| 121 | MP0006082_CNS_inflammation | 0.31345287 |
| 122 | MP0000230_abnormal_systemic_arterial | 0.31111532 |
| 123 | MP0004924_abnormal_behavior | 0.31031103 |
| 124 | MP0005386_behavior/neurological_phenoty | 0.31031103 |
| 125 | MP0001243_abnormal_dermal_layer | 0.30570211 |
| 126 | MP0002168_other_aberrant_phenotype | 0.30470846 |
| 127 | MP0003631_nervous_system_phenotype | 0.29717935 |
| 128 | MP0001845_abnormal_inflammatory_respons | 0.27679497 |
| 129 | MP0001881_abnormal_mammary_gland | 0.27585592 |
| 130 | MP0005164_abnormal_response_to | 0.25822561 |
| 131 | MP0002132_abnormal_respiratory_system | 0.24698423 |
| 132 | MP0002060_abnormal_skin_morphology | 0.24435947 |
| 133 | MP0000427_abnormal_hair_cycle | 0.24015562 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Deep venous thrombosis (HP:0002625) | 7.45636930 |
| 2 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.36213064 |
| 3 | Intrahepatic cholestasis (HP:0001406) | 7.36147244 |
| 4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.66960235 |
| 5 | Prolonged partial thromboplastin time (HP:0003645) | 6.66758091 |
| 6 | Hypobetalipoproteinemia (HP:0003563) | 6.40531936 |
| 7 | Xanthomatosis (HP:0000991) | 6.26847038 |
| 8 | Complement deficiency (HP:0004431) | 5.58836449 |
| 9 | Hyperlipoproteinemia (HP:0010980) | 5.58389359 |
| 10 | Joint hemorrhage (HP:0005261) | 4.87375385 |
| 11 | Hypolipoproteinemia (HP:0010981) | 4.80448481 |
| 12 | Hyperammonemia (HP:0001987) | 4.61714392 |
| 13 | Epidermoid cyst (HP:0200040) | 4.55647778 |
| 14 | Abnormality of the common coagulation pathway (HP:0010990) | 4.54999623 |
| 15 | Hyperglycinemia (HP:0002154) | 4.45116586 |
| 16 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.39995587 |
| 17 | Abnormality of methionine metabolism (HP:0010901) | 4.26501778 |
| 18 | Ketosis (HP:0001946) | 4.25185486 |
| 19 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.22992900 |
| 20 | Hypoalphalipoproteinemia (HP:0003233) | 4.20712905 |
| 21 | Fat malabsorption (HP:0002630) | 4.16007920 |
| 22 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.12954171 |
| 23 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.10574867 |
| 24 | Abnormality of complement system (HP:0005339) | 4.08087165 |
| 25 | Hyperglycinuria (HP:0003108) | 3.91694062 |
| 26 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.91617762 |
| 27 | Abnormality of glycine metabolism (HP:0010895) | 3.91617762 |
| 28 | Hypoglycemic coma (HP:0001325) | 3.87262007 |
| 29 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.84615220 |
| 30 | Abnormality of the intrinsic pathway (HP:0010989) | 3.81488029 |
| 31 | Conjugated hyperbilirubinemia (HP:0002908) | 3.78306890 |
| 32 | Hypercholesterolemia (HP:0003124) | 3.60666556 |
| 33 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.35603369 |
| 34 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.32781441 |
| 35 | Hyperbilirubinemia (HP:0002904) | 3.32533027 |
| 36 | Spontaneous abortion (HP:0005268) | 3.13716086 |
| 37 | Steatorrhea (HP:0002570) | 3.12663897 |
| 38 | Fair hair (HP:0002286) | 3.09890509 |
| 39 | Delayed CNS myelination (HP:0002188) | 3.08181747 |
| 40 | Abnormality of serum amino acid levels (HP:0003112) | 3.08012392 |
| 41 | Abnormality of nucleobase metabolism (HP:0010932) | 3.03667289 |
| 42 | Hypochromic microcytic anemia (HP:0004840) | 3.02582761 |
| 43 | Ketoacidosis (HP:0001993) | 2.98862776 |
| 44 | Hepatocellular carcinoma (HP:0001402) | 2.98617986 |
| 45 | Myocardial infarction (HP:0001658) | 2.97673705 |
| 46 | Skin nodule (HP:0200036) | 2.82085629 |
| 47 | Systemic lupus erythematosus (HP:0002725) | 2.81841896 |
| 48 | Metabolic acidosis (HP:0001942) | 2.74280508 |
| 49 | Abnormality of purine metabolism (HP:0004352) | 2.63193323 |
| 50 | Lethargy (HP:0001254) | 2.59579184 |
| 51 | Acanthocytosis (HP:0001927) | 2.59472289 |
| 52 | Dicarboxylic aciduria (HP:0003215) | 2.56694691 |
| 53 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.56694691 |
| 54 | Arthropathy (HP:0003040) | 2.56148690 |
| 55 | Vascular calcification (HP:0004934) | 2.54549953 |
| 56 | Osteomalacia (HP:0002749) | 2.51786343 |
| 57 | Reduced antithrombin III activity (HP:0001976) | 2.51709141 |
| 58 | Bile duct proliferation (HP:0001408) | 2.51418641 |
| 59 | Abnormal biliary tract physiology (HP:0012439) | 2.51418641 |
| 60 | Glomerulonephritis (HP:0000099) | 2.49762022 |
| 61 | Hypoglycemic seizures (HP:0002173) | 2.49694886 |
| 62 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.47053738 |
| 63 | Abnormal gallbladder morphology (HP:0012437) | 2.46744946 |
| 64 | Spastic diplegia (HP:0001264) | 2.44505464 |
| 65 | Cerebral edema (HP:0002181) | 2.42915946 |
| 66 | Mitral stenosis (HP:0001718) | 2.41441287 |
| 67 | Cholelithiasis (HP:0001081) | 2.40726745 |
| 68 | Gout (HP:0001997) | 2.38949674 |
| 69 | Genetic anticipation (HP:0003743) | 2.38497365 |
| 70 | Neonatal onset (HP:0003623) | 2.34731726 |
| 71 | Irritability (HP:0000737) | 2.33128320 |
| 72 | Amyloidosis (HP:0011034) | 2.32497263 |
| 73 | Abnormal gallbladder physiology (HP:0012438) | 2.32151972 |
| 74 | Cholecystitis (HP:0001082) | 2.32151972 |
| 75 | Pulmonary embolism (HP:0002204) | 2.28032123 |
| 76 | Proximal tubulopathy (HP:0000114) | 2.27723491 |
| 77 | Gingival bleeding (HP:0000225) | 2.27506366 |
| 78 | Cardiovascular calcification (HP:0011915) | 2.25570634 |
| 79 | Abnormality of urine glucose concentration (HP:0011016) | 2.24076117 |
| 80 | Glycosuria (HP:0003076) | 2.24076117 |
| 81 | Esophageal varix (HP:0002040) | 2.20820395 |
| 82 | Malnutrition (HP:0004395) | 2.19548638 |
| 83 | Hyperventilation (HP:0002883) | 2.18534488 |
| 84 | Menorrhagia (HP:0000132) | 2.17285543 |
| 85 | Pancreatitis (HP:0001733) | 2.14046256 |
| 86 | Sensorimotor neuropathy (HP:0007141) | 2.13726866 |
| 87 | Generalized hypopigmentation of hair (HP:0011358) | 2.12898538 |
| 88 | Thrombophlebitis (HP:0004418) | 2.11822310 |
| 89 | Enlarged kidneys (HP:0000105) | 2.10639395 |
| 90 | Brushfield spots (HP:0001088) | 2.10539211 |
| 91 | Late onset (HP:0003584) | 2.08152396 |
| 92 | Vomiting (HP:0002013) | 2.05081735 |
| 93 | Poikilocytosis (HP:0004447) | 2.02979347 |
| 94 | Opisthotonus (HP:0002179) | 2.02496442 |
| 95 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.02459466 |
| 96 | Hemorrhage of the eye (HP:0011885) | 2.01809765 |
| 97 | Generalized aminoaciduria (HP:0002909) | 2.00715982 |
| 98 | Abnormality of the gallbladder (HP:0005264) | 2.00711914 |
| 99 | Purpura (HP:0000979) | 1.99312101 |
| 100 | Progressive cerebellar ataxia (HP:0002073) | 1.90657720 |
| 101 | Rickets (HP:0002748) | 1.90348278 |
| 102 | Abnormality of iron homeostasis (HP:0011031) | 1.89879368 |
| 103 | Renal cortical cysts (HP:0000803) | 1.88526748 |
| 104 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.86461925 |
| 105 | Abnormal cartilage morphology (HP:0002763) | 1.84575271 |
| 106 | Hypophosphatemic rickets (HP:0004912) | 1.84168090 |
| 107 | Hydroxyprolinuria (HP:0003080) | 1.83109189 |
| 108 | Abnormality of proline metabolism (HP:0010907) | 1.83109189 |
| 109 | Elevated hepatic transaminases (HP:0002910) | 1.82543120 |
| 110 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.80012676 |
| 111 | Hypochromic anemia (HP:0001931) | 1.79443414 |
| 112 | Status epilepticus (HP:0002133) | 1.78698813 |
| 113 | Hyperphosphaturia (HP:0003109) | 1.78377065 |
| 114 | Alkalosis (HP:0001948) | 1.78107122 |
| 115 | Nephritis (HP:0000123) | 1.76886406 |
| 116 | Hyperglycemia (HP:0003074) | 1.74526030 |
| 117 | Retinal atrophy (HP:0001105) | 1.73431753 |
| 118 | Gangrene (HP:0100758) | 1.72889438 |
| 119 | Action tremor (HP:0002345) | 1.72052549 |
| 120 | Abnormality of vitamin metabolism (HP:0100508) | 1.71855659 |
| 121 | Abnormality of the hepatic vasculature (HP:0006707) | 1.70462977 |
| 122 | Bifid scrotum (HP:0000048) | 1.67691121 |
| 123 | Potter facies (HP:0002009) | 1.67652683 |
| 124 | Facial shape deformation (HP:0011334) | 1.67652683 |
| 125 | Gaze-evoked nystagmus (HP:0000640) | 1.55599074 |
| 126 | Pendular nystagmus (HP:0012043) | 1.54397910 |
| 127 | Chronic hepatic failure (HP:0100626) | 1.53846424 |
| 128 | Blue irides (HP:0000635) | 1.53460491 |
| 129 | Epistaxis (HP:0000421) | 1.50750749 |
| 130 | Submucous cleft hard palate (HP:0000176) | 1.49463677 |
| 131 | Anorexia (HP:0002039) | 1.47931601 |
| 132 | Dysmetric saccades (HP:0000641) | 1.46535253 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 7.12441269 |
| 2 | FGFR4 | 4.62458817 |
| 3 | SIK1 | 4.50483719 |
| 4 | ERN1 | 4.46667820 |
| 5 | WNK3 | 3.34050095 |
| 6 | TAOK3 | 3.12549963 |
| 7 | INSRR | 3.12530329 |
| 8 | ERBB4 | 3.05956677 |
| 9 | OXSR1 | 2.53708767 |
| 10 | CDK19 | 2.37391827 |
| 11 | MAP2K4 | 2.35987338 |
| 12 | ACVR1B | 2.31971847 |
| 13 | NTRK3 | 2.26786585 |
| 14 | PKN2 | 2.10289686 |
| 15 | MST1R | 2.09465525 |
| 16 | MAPK11 | 1.96054364 |
| 17 | CASK | 1.95720239 |
| 18 | FLT3 | 1.85046726 |
| 19 | PIK3CG | 1.80897723 |
| 20 | MAP4K2 | 1.80742025 |
| 21 | BCR | 1.80253367 |
| 22 | TRIB3 | 1.76984225 |
| 23 | BMPR1B | 1.76763437 |
| 24 | ADRBK2 | 1.76605708 |
| 25 | TYK2 | 1.72424104 |
| 26 | LATS1 | 1.70318881 |
| 27 | FER | 1.53866787 |
| 28 | TXK | 1.51956010 |
| 29 | DAPK2 | 1.49033951 |
| 30 | TNK2 | 1.48702616 |
| 31 | ABL2 | 1.45896274 |
| 32 | PTK6 | 1.44679632 |
| 33 | NEK9 | 1.40736697 |
| 34 | FRK | 1.39918896 |
| 35 | FGFR2 | 1.39302895 |
| 36 | MAPK13 | 1.38830924 |
| 37 | ZAK | 1.30199397 |
| 38 | KDR | 1.28842586 |
| 39 | BRSK2 | 1.27200182 |
| 40 | WNK4 | 1.25899125 |
| 41 | JAK2 | 1.23800238 |
| 42 | MAP3K7 | 1.20908993 |
| 43 | AKT3 | 1.20563373 |
| 44 | PINK1 | 1.16408608 |
| 45 | PRKAA2 | 1.14952459 |
| 46 | ERBB2 | 1.07682729 |
| 47 | MAP2K3 | 1.06019050 |
| 48 | JAK1 | 1.05522908 |
| 49 | TBK1 | 1.04037499 |
| 50 | MKNK2 | 1.02107525 |
| 51 | EIF2AK3 | 1.02058940 |
| 52 | GRK6 | 1.02003690 |
| 53 | MAPK4 | 0.99463972 |
| 54 | MAP3K14 | 0.98248649 |
| 55 | MAP3K10 | 0.97299688 |
| 56 | MAP3K4 | 0.93597910 |
| 57 | PRKCZ | 0.91244856 |
| 58 | TIE1 | 0.90018723 |
| 59 | STK38L | 0.88139598 |
| 60 | EPHB1 | 0.86403329 |
| 61 | MET | 0.82819148 |
| 62 | MAPK12 | 0.82500308 |
| 63 | PRKG1 | 0.82452022 |
| 64 | EPHA3 | 0.82347611 |
| 65 | CAMKK2 | 0.81919309 |
| 66 | MAPK15 | 0.80782689 |
| 67 | CDK6 | 0.79892079 |
| 68 | MAP3K3 | 0.79642785 |
| 69 | NUAK1 | 0.77985983 |
| 70 | PRKACG | 0.76180057 |
| 71 | CAMK1D | 0.75283309 |
| 72 | MAP3K11 | 0.72714530 |
| 73 | CAMK2G | 0.71847143 |
| 74 | PRKCE | 0.71275656 |
| 75 | MAPKAPK3 | 0.69182063 |
| 76 | MUSK | 0.68866038 |
| 77 | IRAK3 | 0.68859310 |
| 78 | CSNK1D | 0.68057313 |
| 79 | DYRK1B | 0.67656488 |
| 80 | CSK | 0.67460360 |
| 81 | PRKAA1 | 0.67338163 |
| 82 | SGK3 | 0.67004195 |
| 83 | GSK3A | 0.66784952 |
| 84 | PRKACA | 0.66376109 |
| 85 | MAP2K6 | 0.65055582 |
| 86 | STK39 | 0.64159927 |
| 87 | MAPK7 | 0.62366298 |
| 88 | FGFR3 | 0.61014698 |
| 89 | ADRBK1 | 0.60232676 |
| 90 | PAK3 | 0.59935977 |
| 91 | RIPK1 | 0.57213973 |
| 92 | CSF1R | 0.56839097 |
| 93 | TGFBR2 | 0.56542634 |
| 94 | TRIM28 | 0.56508481 |
| 95 | CSNK1A1 | 0.56444084 |
| 96 | IKBKE | 0.55466109 |
| 97 | STK3 | 0.54441526 |
| 98 | PRKCB | 0.54275894 |
| 99 | SGK1 | 0.52898492 |
| 100 | NEK1 | 0.51841138 |
| 101 | PDPK1 | 0.51645168 |
| 102 | SGK2 | 0.51259716 |
| 103 | PTK2 | 0.50740569 |
| 104 | PKN1 | 0.50731794 |
| 105 | PRKACB | 0.50724395 |
| 106 | PRKCQ | 0.50545924 |
| 107 | MARK1 | 0.49006463 |
| 108 | CSNK1G1 | 0.48899298 |
| 109 | TAOK2 | 0.48758991 |
| 110 | GRK1 | 0.48663763 |
| 111 | STK38 | 0.46710033 |
| 112 | EPHA4 | 0.46106809 |
| 113 | MAP3K5 | 0.45294757 |
| 114 | IGF1R | 0.43691570 |
| 115 | RPS6KA3 | 0.42966266 |
| 116 | CDK4 | 0.41116454 |
| 117 | RET | 0.40748810 |
| 118 | PRKCG | 0.39964094 |
| 119 | MAP2K1 | 0.39838752 |
| 120 | ICK | 0.39624718 |
| 121 | MAP3K6 | 0.37667791 |
| 122 | MAP3K13 | 0.36121670 |
| 123 | NLK | 0.35178118 |
| 124 | MTOR | 0.34817594 |
| 125 | SGK223 | 0.34468359 |
| 126 | SGK494 | 0.34468359 |
| 127 | CSNK1E | 0.34060706 |
| 128 | EIF2AK1 | 0.33780155 |
| 129 | EGFR | 0.33572378 |
| 130 | CAMK4 | 0.32331636 |
| 131 | BLK | 0.32050120 |
| 132 | IRAK1 | 0.31385167 |
| 133 | PDK1 | 0.30939826 |
| 134 | DYRK2 | 0.30596887 |
| 135 | YES1 | 0.30588104 |
| 136 | MAP3K1 | 0.30524152 |
| 137 | RPS6KB1 | 0.30461536 |
| 138 | PBK | 0.29531757 |
| 139 | FGFR1 | 0.27769850 |
| 140 | IRAK2 | 0.27341236 |
| 141 | CSNK1G2 | 0.26999282 |
| 142 | CAMK1G | 0.26735037 |
| 143 | CAMK2A | 0.25843289 |
| 144 | PRKCA | 0.25593729 |
| 145 | SIK2 | 0.24991074 |
| 146 | LATS2 | 0.24901470 |
| 147 | GRK7 | 0.24380516 |
| 148 | PDK3 | 0.24371012 |
| 149 | PDK4 | 0.24371012 |
| 150 | CSNK1G3 | 0.24076082 |
| 151 | PIK3CA | 0.23666801 |
| 152 | CSNK2A1 | 0.23138819 |
| 153 | MAP2K7 | 0.23121348 |
| 154 | MAPKAPK5 | 0.22637320 |
| 155 | TEC | 0.22068004 |
| 156 | PLK4 | 0.22043335 |
| 157 | ABL1 | 0.21998575 |
| 158 | BMX | 0.21198206 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.57928420 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.65042755 |
| 3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.42958008 |
| 4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.30500115 |
| 5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.09235678 |
| 6 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.83466040 |
| 7 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.69376049 |
| 8 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.66660714 |
| 9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.63400920 |
| 10 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.54593493 |
| 11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.49424410 |
| 12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.38460820 |
| 13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.21246719 |
| 14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.13658831 |
| 15 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.09756112 |
| 16 | Peroxisome_Homo sapiens_hsa04146 | 2.07698969 |
| 17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.93977989 |
| 18 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.92192501 |
| 19 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.91139160 |
| 20 | Histidine metabolism_Homo sapiens_hsa00340 | 1.89210678 |
| 21 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.88530050 |
| 22 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.87532414 |
| 23 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.81591420 |
| 24 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.80480441 |
| 25 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.75686234 |
| 26 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.75304333 |
| 27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.74346911 |
| 28 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.71090156 |
| 29 | Retinol metabolism_Homo sapiens_hsa00830 | 1.68292740 |
| 30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.65576922 |
| 31 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.57210526 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.57062931 |
| 33 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.56882441 |
| 34 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.53232854 |
| 35 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.51532493 |
| 36 | Bile secretion_Homo sapiens_hsa04976 | 1.49264902 |
| 37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.44844421 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35365900 |
| 39 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.33673036 |
| 40 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.33153987 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.31514187 |
| 42 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.26973121 |
| 43 | ABC transporters_Homo sapiens_hsa02010 | 1.21435229 |
| 44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.19789578 |
| 45 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.19762201 |
| 46 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.19354458 |
| 47 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.15905841 |
| 48 | Carbon metabolism_Homo sapiens_hsa01200 | 1.12468165 |
| 49 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.03706597 |
| 50 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.01350172 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.97720322 |
| 52 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.96703575 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.95847323 |
| 54 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.94401646 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.93063143 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.88206026 |
| 57 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.85837330 |
| 58 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.82709001 |
| 59 | Lysine degradation_Homo sapiens_hsa00310 | 0.80956400 |
| 60 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.75725288 |
| 61 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.68427535 |
| 62 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.66834329 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.61866317 |
| 64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.55190817 |
| 65 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.55023869 |
| 66 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.49839382 |
| 67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.45657952 |
| 68 | Prion diseases_Homo sapiens_hsa05020 | 0.40570372 |
| 69 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.39302236 |
| 70 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.24429479 |
| 71 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.24372762 |
| 72 | Galactose metabolism_Homo sapiens_hsa00052 | 0.24336594 |
| 73 | Insulin resistance_Homo sapiens_hsa04931 | 0.24200850 |
| 74 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.23198081 |
| 75 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.21612119 |
| 76 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.20906111 |
| 77 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.17824147 |
| 78 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.16444118 |
| 79 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.16307473 |
| 80 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.14414915 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.10987679 |
| 82 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.08060323 |
| 83 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.06561322 |
| 84 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.06420563 |
| 85 | Mineral absorption_Homo sapiens_hsa04978 | 0.04671232 |
| 86 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.03030190 |
| 87 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.02655480 |
| 88 | Pertussis_Homo sapiens_hsa05133 | -0.2466793 |
| 89 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | -0.2328908 |
| 90 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.2276857 |
| 91 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.2262040 |
| 92 | Amoebiasis_Homo sapiens_hsa05146 | -0.2258800 |
| 93 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1978819 |
| 94 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1964074 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1960589 |
| 96 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1852597 |
| 97 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.1697324 |
| 98 | Hepatitis C_Homo sapiens_hsa05160 | -0.1685295 |
| 99 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1591854 |
| 100 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1553670 |
| 101 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | -0.1492061 |
| 102 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.1354247 |
| 103 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1326083 |
| 104 | Olfactory transduction_Homo sapiens_hsa04740 | -0.1289776 |
| 105 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1245384 |
| 106 | Nicotine addiction_Homo sapiens_hsa05033 | -0.1244468 |
| 107 | GABAergic synapse_Homo sapiens_hsa04727 | -0.1025089 |
| 108 | Circadian rhythm_Homo sapiens_hsa04710 | -0.0981207 |
| 109 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.0927899 |
| 110 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0889611 |
| 111 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0682476 |
| 112 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0582105 |
| 113 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0383664 |
| 114 | Phototransduction_Homo sapiens_hsa04744 | -0.0186785 |

