CPNE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.44247694
2Golgi transport vesicle coating (GO:0048200)5.17329349
3COPI coating of Golgi vesicle (GO:0048205)5.17329349
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68381264
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68381264
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.30242435
7antigen processing and presentation of endogenous antigen (GO:0019883)4.10027311
8DNA unwinding involved in DNA replication (GO:0006268)3.94890234
9GDP-mannose metabolic process (GO:0019673)3.93722050
10positive regulation of gamma-delta T cell activation (GO:0046645)3.86144186
11establishment of viral latency (GO:0019043)3.83319097
12regulation of mitochondrial translation (GO:0070129)3.80399990
13establishment of integrated proviral latency (GO:0075713)3.79202651
14vascular endothelial growth factor signaling pathway (GO:0038084)3.65711985
15metallo-sulfur cluster assembly (GO:0031163)3.65166485
16iron-sulfur cluster assembly (GO:0016226)3.65166485
17definitive hemopoiesis (GO:0060216)3.57273562
18pinocytosis (GO:0006907)3.48510123
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.41783548
20peptidyl-arginine omega-N-methylation (GO:0035247)3.39907781
21regulation of cellular amino acid metabolic process (GO:0006521)3.36491999
22protein retention in ER lumen (GO:0006621)3.33453796
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31452009
24mannosylation (GO:0097502)3.28659090
25negative regulation of B cell apoptotic process (GO:0002903)3.28298851
26negative regulation of DNA-templated transcription, elongation (GO:0032785)3.26298984
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24852868
28signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23200240
29intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23200240
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20788548
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20788548
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20788548
33nuclear pore complex assembly (GO:0051292)3.19064428
34regulation of gamma-delta T cell differentiation (GO:0045586)3.18767469
35NADPH regeneration (GO:0006740)3.16135251
36signal transduction involved in DNA damage checkpoint (GO:0072422)3.15610211
37signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15610211
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.14733238
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.13272555
40GMP metabolic process (GO:0046037)3.09451220
41regulation of gamma-delta T cell activation (GO:0046643)3.08821987
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08332180
43glucose catabolic process (GO:0006007)3.08142564
44negative regulation of phagocytosis (GO:0050765)3.06061677
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00561070
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99155413
47regulation of protein heterodimerization activity (GO:0043497)2.96784523
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.96252109
49endothelial tube morphogenesis (GO:0061154)2.95840285
50morphogenesis of an endothelium (GO:0003159)2.95840285
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94181521
52nuclear pore organization (GO:0006999)2.93430688
53plasma lipoprotein particle assembly (GO:0034377)2.91410712
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91123232
55negative regulation of ligase activity (GO:0051352)2.91123232
56viral transcription (GO:0019083)2.86482070
57purine deoxyribonucleotide catabolic process (GO:0009155)2.84876157
58pentose metabolic process (GO:0019321)2.84302919
59formation of translation preinitiation complex (GO:0001731)2.84234334
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83253329
61base-excision repair (GO:0006284)2.81527764
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80564322
63proline biosynthetic process (GO:0006561)2.79888370
64translational termination (GO:0006415)2.78795211
65nuclear envelope reassembly (GO:0031468)2.77293824
66mitotic nuclear envelope reassembly (GO:0007084)2.77293824
67base-excision repair, AP site formation (GO:0006285)2.77217769
68antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72945538
69snRNA processing (GO:0016180)2.72727150
70ribosomal small subunit assembly (GO:0000028)2.72533403
71regulation of cholesterol esterification (GO:0010872)2.71958174
72peptidyl-arginine N-methylation (GO:0035246)2.70743465
73peptidyl-arginine methylation (GO:0018216)2.70743465
74establishment of endothelial barrier (GO:0061028)2.68845266
75deoxyribonucleotide catabolic process (GO:0009264)2.68453966
76branched-chain amino acid catabolic process (GO:0009083)2.67964090
77protein deneddylation (GO:0000338)2.67828525
78glycolytic process (GO:0006096)2.67512212
79protein localization to kinetochore (GO:0034501)2.67476565
80UV protection (GO:0009650)2.66804737
81positive regulation of cell cycle arrest (GO:0071158)2.66553929
82lipopolysaccharide biosynthetic process (GO:0009103)2.65838146
83DNA strand elongation involved in DNA replication (GO:0006271)2.65696977
84cellular response to interleukin-4 (GO:0071353)2.65247279
85negative regulation of cell size (GO:0045792)2.64381063
86T cell apoptotic process (GO:0070231)2.64323802
87cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.64215226
88proteasome assembly (GO:0043248)2.62749511
89positive regulation of B cell differentiation (GO:0045579)2.62291900
90positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.61905673
91mitotic nuclear envelope disassembly (GO:0007077)2.61686062
92leukocyte aggregation (GO:0070486)2.61276796
93GPI anchor biosynthetic process (GO:0006506)2.60631967
94lymph vessel development (GO:0001945)2.59772570
95Arp2/3 complex-mediated actin nucleation (GO:0034314)2.57540900
96DNA strand elongation (GO:0022616)2.57403255
97deoxyribose phosphate catabolic process (GO:0046386)2.56822973
98regulation of translation in response to stress (GO:0043555)2.56511840
99positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.55733080
100negative T cell selection (GO:0043383)2.55308432
101monoubiquitinated protein deubiquitination (GO:0035520)2.54992802
102mRNA transcription from RNA polymerase II promoter (GO:0042789)2.54570541
103regulation of cell cycle arrest (GO:0071156)2.53160533
104germ cell migration (GO:0008354)2.52646878
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.52387011
106translational elongation (GO:0006414)2.52121080
107sprouting angiogenesis (GO:0002040)2.51521310
108regulation of superoxide anion generation (GO:0032928)2.51353273
109snRNA metabolic process (GO:0016073)2.50879126
110guanosine-containing compound biosynthetic process (GO:1901070)2.50296614
111dosage compensation (GO:0007549)2.50157854
112DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.50004311
113deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.49483031
114membrane disassembly (GO:0030397)2.48858587
115nuclear envelope disassembly (GO:0051081)2.48858587
116angiogenesis involved in wound healing (GO:0060055)2.48188392
117negative thymic T cell selection (GO:0045060)2.48174772
118pore complex assembly (GO:0046931)2.47815597
119viral mRNA export from host cell nucleus (GO:0046784)2.46237682
120galactose catabolic process (GO:0019388)2.45994764
121folic acid-containing compound biosynthetic process (GO:0009396)2.45397463
122antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.44704537
123NIK/NF-kappaB signaling (GO:0038061)2.44051281
124maturation of SSU-rRNA (GO:0030490)2.43906342
125nucleotide salvage (GO:0043173)2.43829660
126purine deoxyribonucleotide metabolic process (GO:0009151)2.42176500
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.42051933
128response to interleukin-15 (GO:0070672)2.41430990
129transcription-coupled nucleotide-excision repair (GO:0006283)2.41414057
130positive regulation of ligase activity (GO:0051351)2.41078373
131pentose-phosphate shunt (GO:0006098)2.41051560
132cullin deneddylation (GO:0010388)2.41013835
133protein-lipid complex assembly (GO:0065005)2.38922441
134pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.38498427
135histone arginine methylation (GO:0034969)2.37949420
136telomere maintenance via semi-conservative replication (GO:0032201)2.37511146
137lipopolysaccharide metabolic process (GO:0008653)2.37249135
138tricarboxylic acid metabolic process (GO:0072350)2.36747106
139actin nucleation (GO:0045010)2.36546291
140response to laminar fluid shear stress (GO:0034616)2.36393588
141pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.35735851
1424-hydroxyproline metabolic process (GO:0019471)2.35185379
143virion assembly (GO:0019068)2.34955029
144patterning of blood vessels (GO:0001569)2.34864524
145pyrimidine nucleoside salvage (GO:0043097)2.33862657
146fat-soluble vitamin biosynthetic process (GO:0042362)2.33478509
147negative regulation of RNA splicing (GO:0033119)2.32919226
148regulation of B cell differentiation (GO:0045577)2.31843676
149positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31232609
150regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31187405
151positive regulation of natural killer cell differentiation (GO:0032825)2.29783608
152response to UV-C (GO:0010225)2.29613087
153positive regulation of lipid kinase activity (GO:0090218)2.29329599
154mRNA transcription (GO:0009299)2.28723659
155endodermal cell differentiation (GO:0035987)2.28678395
156mitotic recombination (GO:0006312)2.27824007
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.26399871
158radial glial cell differentiation (GO:0060019)2.23862815
159positive regulation of epithelial to mesenchymal transition (GO:0010718)2.23273257
160antigen processing and presentation via MHC class Ib (GO:0002475)2.22498424
161DNA duplex unwinding (GO:0032508)2.21285215
162positive thymic T cell selection (GO:0045059)2.20630115
163telomere maintenance via recombination (GO:0000722)2.20492671
164IMP biosynthetic process (GO:0006188)2.20128361
165DNA replication initiation (GO:0006270)2.20089767
166viral life cycle (GO:0019058)2.19764112
167histone mRNA catabolic process (GO:0071044)2.19153150
168DNA geometric change (GO:0032392)2.18928406
169translational initiation (GO:0006413)2.17836925
170immunoglobulin mediated immune response (GO:0016064)2.17065629
171B cell mediated immunity (GO:0019724)2.16107578
172regulation of interleukin-12 biosynthetic process (GO:0045075)2.15077626
173lymphocyte apoptotic process (GO:0070227)2.14266862
174thymic T cell selection (GO:0045061)2.12508702
175positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.11494350
176negative regulation of interleukin-12 production (GO:0032695)2.09459655
177SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.08765196
178protein localization to chromosome, centromeric region (GO:0071459)2.08311435
179cellular protein complex disassembly (GO:0043624)2.08287927
180translesion synthesis (GO:0019985)2.08071827
181natural killer cell differentiation (GO:0001779)2.07513228
182sequestering of actin monomers (GO:0042989)2.07094624
183trabecula morphogenesis (GO:0061383)2.06196056
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.05139626
185mitotic chromosome condensation (GO:0007076)2.04474298
186regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.03545198
187negative regulation of stress fiber assembly (GO:0051497)2.02955103
188chondrocyte proliferation (GO:0035988)2.02606990
189T cell homeostasis (GO:0043029)2.01631824
190protein targeting to ER (GO:0045047)2.01048882
1913-UTR-mediated mRNA stabilization (GO:0070935)2.01044657
192regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.00359723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.26694405
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.97985712
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.56646209
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44580403
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02860258
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01064263
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98102061
8MYC_22102868_ChIP-Seq_BL_Human2.90418493
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89298776
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86801666
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64607488
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.50853767
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35540532
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34945710
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30090164
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.14368358
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11053926
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.10712490
19VDR_21846776_ChIP-Seq_THP-1_Human2.10567416
20* GABP_19822575_ChIP-Seq_HepG2_Human2.10243698
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08486294
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02338843
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00262629
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98087231
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.97146142
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97085315
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91712075
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89653677
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89242610
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88623671
31AR_21909140_ChIP-Seq_LNCAP_Human1.86852084
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86728937
33CLOCK_20551151_ChIP-Seq_293T_Human1.85095177
34MAF_26560356_Chip-Seq_TH1_Human1.84980563
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.84510901
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.80953770
37MYB_26560356_Chip-Seq_TH2_Human1.80695436
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78838218
39UTX_26944678_Chip-Seq_JUKART_Human1.76057182
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.75605842
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75597987
42ZNF263_19887448_ChIP-Seq_K562_Human1.71192050
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70893218
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67766662
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66124441
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66098880
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.63611245
48XRN2_22483619_ChIP-Seq_HELA_Human1.61580271
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59436168
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57317494
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50696179
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49855372
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49422085
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49039359
55MYB_26560356_Chip-Seq_TH1_Human1.49010441
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48119002
57SPI1_23547873_ChIP-Seq_NB4_Human1.47764846
58TCF7_22412390_ChIP-Seq_EML_Mouse1.47418940
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.45306302
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.44943830
61SCL_19346495_ChIP-Seq_HPC-7_Human1.44737748
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44232000
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41819573
64KDM5A_27292631_Chip-Seq_BREAST_Human1.41548634
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41547955
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41489438
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38954474
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38808027
69* CIITA_25753668_ChIP-Seq_RAJI_Human1.37358150
70VDR_24763502_ChIP-Seq_THP-1_Human1.36892632
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36837772
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36761064
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36475432
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36239094
75MAF_26560356_Chip-Seq_TH2_Human1.34977823
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33747258
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33718256
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33682231
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33127151
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32824030
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31617890
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.30367310
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30280548
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30230631
85ELK1_19687146_ChIP-ChIP_HELA_Human1.28812970
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.28604426
87RUNX_20019798_ChIP-Seq_JUKART_Human1.27311992
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24928549
89TFEB_21752829_ChIP-Seq_HELA_Human1.24178736
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22632181
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22384621
92* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22199664
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22060612
94LXR_22292898_ChIP-Seq_THP-1_Human1.21924430
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21718285
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.20893209
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20084384
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18915964
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18640968
100BCL6_27268052_Chip-Seq_Bcells_Human1.18523719
101P68_20966046_ChIP-Seq_HELA_Human1.17755531
102GABP_17652178_ChIP-ChIP_JURKAT_Human1.17672308
103VDR_23849224_ChIP-Seq_CD4+_Human1.16151498
104FOXP3_21729870_ChIP-Seq_TREG_Human1.16100256
105EST1_17652178_ChIP-ChIP_JURKAT_Human1.15459720
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13891316
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13609968
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13340177
109* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13220310
110KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11914377
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11708073
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11182911
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.10780027
114ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10611416
115KDM2B_26808549_Chip-Seq_DND41_Human1.09960267
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08828133
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08561845
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08321246
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.07730617
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07411343
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06555030
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06300549
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06300549
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05564447
125TTF2_22483619_ChIP-Seq_HELA_Human1.05351904
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04808160
127DCP1A_22483619_ChIP-Seq_HELA_Human1.04456275
128BP1_19119308_ChIP-ChIP_Hs578T_Human1.04172936
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04059107
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03925764
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03004190
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.02890196
133SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01982184
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01811196
135* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01755420
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00945788
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00843854
138CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00049031
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99811576
140BCOR_27268052_Chip-Seq_Bcells_Human0.99476786
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99083915
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98859625
143RACK7_27058665_Chip-Seq_MCF-7_Human0.98482475
144* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98330476
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98099158
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98079030
147FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96745508
148MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96300529
149MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95545224
150* ATF3_27146783_Chip-Seq_COLON_Human0.95095274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.29010463
2MP0008438_abnormal_cutaneous_collagen3.16752454
3MP0003191_abnormal_cellular_cholesterol3.07166019
4MP0003122_maternal_imprinting2.88893022
5MP0010352_gastrointestinal_tract_polyps2.72222876
6MP0003172_abnormal_lysosome_physiology2.62792106
7MP0008260_abnormal_autophagy2.45113679
8MP0005075_abnormal_melanosome_morpholog2.40377382
9MP0003279_aneurysm2.36311182
10MP0000372_irregular_coat_pigmentation2.33547007
11MP0004808_abnormal_hematopoietic_stem2.31450696
12MP0006054_spinal_hemorrhage2.28383971
13MP0003705_abnormal_hypodermis_morpholog2.20877297
14MP0003806_abnormal_nucleotide_metabolis2.17401637
15MP0002396_abnormal_hematopoietic_system2.13222300
16MP0003123_paternal_imprinting2.12240023
17MP0005275_abnormal_skin_tensile2.08230570
18MP0003566_abnormal_cell_adhesion2.04047961
19MP0002166_altered_tumor_susceptibility2.00604060
20MP0003763_abnormal_thymus_physiology2.00222112
21MP0003436_decreased_susceptibility_to1.96769274
22MP0008007_abnormal_cellular_replicative1.96124131
23MP0009840_abnormal_foam_cell1.92825089
24MP0001958_emphysema1.85743360
25MP0001835_abnormal_antigen_presentation1.82845856
26MP0003077_abnormal_cell_cycle1.81497945
27MP0000685_abnormal_immune_system1.80826508
28MP0003786_premature_aging1.78791287
29MP0009333_abnormal_splenocyte_physiolog1.78531317
30MP0002877_abnormal_melanocyte_morpholog1.75934740
31MP0009278_abnormal_bone_marrow1.75485205
32MP0005023_abnormal_wound_healing1.73928318
33MP0001879_abnormal_lymphatic_vessel1.68297836
34MP0002006_tumorigenesis1.66486434
35MP0001545_abnormal_hematopoietic_system1.66007899
36MP0005397_hematopoietic_system_phenotyp1.66007899
37MP0003315_abnormal_perineum_morphology1.62897889
38MP0005451_abnormal_body_composition1.62501016
39MP0002398_abnormal_bone_marrow1.62144279
40MP0003300_gastrointestinal_ulcer1.61218239
41MP0005503_abnormal_tendon_morphology1.60323236
42MP0003693_abnormal_embryo_hatching1.60079489
43MP0001800_abnormal_humoral_immune1.59403345
44MP0008057_abnormal_DNA_replication1.58361771
45MP0003111_abnormal_nucleus_morphology1.55395515
46MP0003121_genomic_imprinting1.51686997
47MP0002132_abnormal_respiratory_system1.51648893
48MP0010094_abnormal_chromosome_stability1.49654431
49MP0005408_hypopigmentation1.49194603
50MP0000358_abnormal_cell_content/1.47638038
51MP0002452_abnormal_antigen_presenting1.46276936
52MP0002420_abnormal_adaptive_immunity1.46240696
53MP0003303_peritoneal_inflammation1.45002611
54MP0002405_respiratory_system_inflammati1.44942162
55MP0000858_altered_metastatic_potential1.44600391
56MP0001819_abnormal_immune_cell1.43353482
57MP0005257_abnormal_intraocular_pressure1.42660428
58MP0004957_abnormal_blastocyst_morpholog1.40095945
59MP0002722_abnormal_immune_system1.39347095
60MP0000703_abnormal_thymus_morphology1.38287507
61MP0005076_abnormal_cell_differentiation1.37375287
62MP0002163_abnormal_gland_morphology1.36683634
63MP0000490_abnormal_crypts_of1.35881435
64MP0003091_abnormal_cell_migration1.35822626
65MP0000767_abnormal_smooth_muscle1.34895162
66MP0004264_abnormal_extraembryonic_tissu1.34837773
67MP0005387_immune_system_phenotype1.34769435
68MP0001790_abnormal_immune_system1.34769435
69MP0004272_abnormal_basement_membrane1.34148279
70MP0000733_abnormal_muscle_development1.32934362
71MP0005671_abnormal_response_to1.32780830
72MP0000689_abnormal_spleen_morphology1.32256922
73MP0005000_abnormal_immune_tolerance1.31357186
74MP0010307_abnormal_tumor_latency1.30799753
75MP0000350_abnormal_cell_proliferation1.30570777
76MP0009785_altered_susceptibility_to1.29394167
77MP0000716_abnormal_immune_system1.28155260
78MP0003448_altered_tumor_morphology1.27341006
79MP0002723_abnormal_immune_serum1.25056851
80MP0002429_abnormal_blood_cell1.24101473
81MP0005377_hearing/vestibular/ear_phenot1.23276228
82MP0003878_abnormal_ear_physiology1.23276228
83MP0001730_embryonic_growth_arrest1.22244706
84MP0003724_increased_susceptibility_to1.21433005
85MP0002938_white_spotting1.20755561
86MP0000371_diluted_coat_color1.19684973
87MP0001915_intracranial_hemorrhage1.19506275
88MP0001764_abnormal_homeostasis1.18295392
89MP0005464_abnormal_platelet_physiology1.16624551
90MP0005025_abnormal_response_to1.16355941
91MP0002419_abnormal_innate_immunity1.15436511
92MP0005084_abnormal_gallbladder_morpholo1.14627128
93MP0010155_abnormal_intestine_physiology1.14162028
94MP0002933_joint_inflammation1.13471594
95MP0001533_abnormal_skeleton_physiology1.11320412
96MP0001661_extended_life_span1.11263945
97MP0001853_heart_inflammation1.10862145
98MP0005623_abnormal_meninges_morphology1.09000432
99MP0002019_abnormal_tumor_incidence1.07493125
100MP0010368_abnormal_lymphatic_system1.07252500
101MP0005360_urolithiasis1.07023303
102MP0002086_abnormal_extraembryonic_tissu1.05871200
103MP0000516_abnormal_urinary_system1.04433377
104MP0005367_renal/urinary_system_phenotyp1.04433377
105MP0002653_abnormal_ependyma_morphology1.03651425
106MP0003943_abnormal_hepatobiliary_system1.03026831
107MP0002075_abnormal_coat/hair_pigmentati1.02692496
108MP0003186_abnormal_redox_activity1.02556181
109MP0006035_abnormal_mitochondrial_morpho1.02281398
110MP0001243_abnormal_dermal_layer1.00905815
111MP0000598_abnormal_liver_morphology1.00159905
112MP0001873_stomach_inflammation0.98701207
113MP0009697_abnormal_copulation0.98242748
114MP0005083_abnormal_biliary_tract0.98236773
115MP0004947_skin_inflammation0.97786249
116MP0000465_gastrointestinal_hemorrhage0.96799174
117MP0000003_abnormal_adipose_tissue0.96773474
118MP0006292_abnormal_olfactory_placode0.96401319
119MP0002925_abnormal_cardiovascular_devel0.94725800
120MP0003984_embryonic_growth_retardation0.94431780
121MP0008058_abnormal_DNA_repair0.93196306
122MP0003567_abnormal_fetal_cardiomyocyte0.93130218
123MP0001697_abnormal_embryo_size0.92976600
124MP0002060_abnormal_skin_morphology0.92937014
125MP0005380_embryogenesis_phenotype0.92807876
126MP0001672_abnormal_embryogenesis/_devel0.92807876
127MP0002088_abnormal_embryonic_growth/wei0.92432798
128MP0008932_abnormal_embryonic_tissue0.91567909
129MP0009053_abnormal_anal_canal0.90354275
130MP0004197_abnormal_fetal_growth/weight/0.90332451
131MP0005171_absent_coat_pigmentation0.89562024
132MP0010030_abnormal_orbit_morphology0.89449581
133MP0000609_abnormal_liver_physiology0.89229025
134MP0005390_skeleton_phenotype0.88822399
135MP0000015_abnormal_ear_pigmentation0.85977609
136MP0005384_cellular_phenotype0.85777260
137MP0001614_abnormal_blood_vessel0.84278874
138MP0001845_abnormal_inflammatory_respons0.84119861
139MP0008469_abnormal_protein_level0.82349125
140MP0005330_cardiomyopathy0.82220249
141MP0003866_abnormal_defecation0.82088378
142MP0005365_abnormal_bile_salt0.82005378
143MP0002148_abnormal_hypersensitivity_rea0.81676021
144MP0002128_abnormal_blood_circulation0.81175161
145MP0010329_abnormal_lipoprotein_level0.80588979
146MP0002080_prenatal_lethality0.79586551
147MP0000639_abnormal_adrenal_gland0.79548408
148MP0005220_abnormal_exocrine_pancreas0.78383460
149MP0001293_anophthalmia0.78293366
150MP0003950_abnormal_plasma_membrane0.77735677
151MP0003656_abnormal_erythrocyte_physiolo0.77475452
152MP0000313_abnormal_cell_death0.76678793
153MP0009384_cardiac_valve_regurgitation0.76642208
154MP0005508_abnormal_skeleton_morphology0.75826446

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.26942283
2Cholecystitis (HP:0001082)3.87095646
3Abnormal gallbladder physiology (HP:0012438)3.87095646
4Abnormality of glycolysis (HP:0004366)3.66126735
5Entropion (HP:0000621)3.38596149
6Type I transferrin isoform profile (HP:0003642)3.37629603
7Premature rupture of membranes (HP:0001788)3.36990753
8Deep venous thrombosis (HP:0002625)3.26809432
9Increased serum pyruvate (HP:0003542)3.15655337
10Hypoplasia of the capital femoral epiphysis (HP:0003090)3.09896205
11Ankle contracture (HP:0006466)3.00943672
12Abnormal protein glycosylation (HP:0012346)3.00138882
13Abnormal glycosylation (HP:0012345)3.00138882
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.00138882
15Abnormal protein N-linked glycosylation (HP:0012347)3.00138882
16Aortic dissection (HP:0002647)2.99113529
17Microvesicular hepatic steatosis (HP:0001414)2.98932132
18Aortic aneurysm (HP:0004942)2.90291357
19Dilatation of the ascending aorta (HP:0005111)2.89735337
20Cerebral aneurysm (HP:0004944)2.88880410
21Chronic otitis media (HP:0000389)2.82108632
22Recurrent viral infections (HP:0004429)2.79652986
23Hepatocellular necrosis (HP:0001404)2.71675086
24Increased density of long bones (HP:0006392)2.71590724
25Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.68674514
26Absent epiphyses (HP:0010577)2.68674514
27Recurrent bronchitis (HP:0002837)2.68005017
28Abnormal platelet volume (HP:0011876)2.64617630
29Broad alveolar ridges (HP:0000187)2.64031497
30Persistence of primary teeth (HP:0006335)2.62217456
31Nonimmune hydrops fetalis (HP:0001790)2.59350195
32Short 4th metacarpal (HP:0010044)2.58814461
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58814461
34Poikiloderma (HP:0001029)2.58466375
35Shallow orbits (HP:0000586)2.57315633
36Severe combined immunodeficiency (HP:0004430)2.56153391
37Petechiae (HP:0000967)2.52895223
38Abnormality of the peritoneum (HP:0002585)2.50649673
39Peritonitis (HP:0002586)2.50266829
40Growth hormone excess (HP:0000845)2.49261518
41Pustule (HP:0200039)2.43913503
42Increased mean platelet volume (HP:0011877)2.42608931
43Selective tooth agenesis (HP:0001592)2.42423510
44Hepatic necrosis (HP:0002605)2.40949156
45Cellulitis (HP:0100658)2.40226001
46Prolonged neonatal jaundice (HP:0006579)2.39071427
47Delayed CNS myelination (HP:0002188)2.37387911
48Rough bone trabeculation (HP:0100670)2.37222555
49Recurrent fungal infections (HP:0002841)2.36980816
50T lymphocytopenia (HP:0005403)2.34903762
51Wrist flexion contracture (HP:0001239)2.34790640
52Hepatosplenomegaly (HP:0001433)2.33788849
53Spastic paraparesis (HP:0002313)2.33018786
54Abnormality of T cell number (HP:0011839)2.30841375
55Myositis (HP:0100614)2.30316280
56Glucose intolerance (HP:0000833)2.28821667
57Syringomyelia (HP:0003396)2.27643710
58Spinal cord lesions (HP:0100561)2.27643710
59Eczematoid dermatitis (HP:0000976)2.26840323
60Soft skin (HP:0000977)2.24723459
61Joint hemorrhage (HP:0005261)2.24574199
62Cervical subluxation (HP:0003308)2.24449846
63Broad metatarsal (HP:0001783)2.22913183
64Orthostatic hypotension (HP:0001278)2.22618522
65Cutaneous melanoma (HP:0012056)2.22242463
66Ragged-red muscle fibers (HP:0003200)2.21860921
67Biconcave vertebral bodies (HP:0004586)2.20504339
68Elevated erythrocyte sedimentation rate (HP:0003565)2.20359826
69Mitral valve prolapse (HP:0001634)2.18611718
70Thrombocytosis (HP:0001894)2.18427972
71Hematochezia (HP:0002573)2.16381634
72Vertebral compression fractures (HP:0002953)2.16102592
73Increased IgM level (HP:0003496)2.15662995
74Autoimmune thrombocytopenia (HP:0001973)2.14409504
75Opisthotonus (HP:0002179)2.12769656
76Genu recurvatum (HP:0002816)2.12373991
77Pancreatic islet-cell hyperplasia (HP:0004510)2.11152647
78Amyloidosis (HP:0011034)2.10059757
79Increased IgE level (HP:0003212)2.10033553
80J-shaped sella turcica (HP:0002680)2.08905686
81Abnormality of the calcaneus (HP:0008364)2.08389085
82Eosinophilia (HP:0001880)2.01400452
83Emotional lability (HP:0000712)2.01348847
84Panhypogammaglobulinemia (HP:0003139)1.99716949
85Osteolytic defects of the phalanges of the hand (HP:0009771)1.98868285
86Osteolytic defects of the hand bones (HP:0009699)1.98868285
87Abnormality of T cells (HP:0002843)1.98662701
88Aortic regurgitation (HP:0001659)1.98596238
89Acute hepatic failure (HP:0006554)1.98054619
90Abnormal delayed hypersensitivity skin test (HP:0002963)1.97733829
91Vacuolated lymphocytes (HP:0001922)1.97663846
92IgM deficiency (HP:0002850)1.97516363
93Spontaneous hematomas (HP:0007420)1.96457673
94Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96374951
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96374951
96Abnormality of the distal phalanges of the toes (HP:0010182)1.96146574
97Reduced antithrombin III activity (HP:0001976)1.96130215
98Bowel diverticulosis (HP:0005222)1.94928602
99Fatigue (HP:0012378)1.93697525
100Secondary amenorrhea (HP:0000869)1.93544902
101Prolonged bleeding time (HP:0003010)1.92393353
102Abnormality of the common coagulation pathway (HP:0010990)1.91931941
103Mesomelia (HP:0003027)1.91402697
104Small epiphyses (HP:0010585)1.90902139
105Abnormality of the nasal mucosa (HP:0000433)1.90508374
106Bicuspid aortic valve (HP:0001647)1.88615144
107Camptodactyly of toe (HP:0001836)1.88167368
108Aplastic anemia (HP:0001915)1.87381991
109Retinal dysplasia (HP:0007973)1.86533707
110Brittle hair (HP:0002299)1.85670189
111Nasal polyposis (HP:0100582)1.84948066
112Long eyelashes (HP:0000527)1.84689155
113Leukocytosis (HP:0001974)1.84146035
114Atrophic scars (HP:0001075)1.84047612
115Seborrheic dermatitis (HP:0001051)1.83219150
116High pitched voice (HP:0001620)1.82498810
117Hand muscle atrophy (HP:0009130)1.81967384
118Bladder diverticulum (HP:0000015)1.79677300
119B lymphocytopenia (HP:0010976)1.78987120
120Abnormality of B cell number (HP:0010975)1.78987120
121Acute myeloid leukemia (HP:0004808)1.78375740
122Gingival bleeding (HP:0000225)1.77936157
123Broad palm (HP:0001169)1.77732693
124Abnormality of the anterior horn cell (HP:0006802)1.77569736
125Degeneration of anterior horn cells (HP:0002398)1.77569736
126Joint contractures involving the joints of the feet (HP:0100492)1.77372371
127Flexion contracture of toe (HP:0005830)1.77372371
128Abnormality of carpal bone ossification (HP:0006257)1.77213863
129Combined immunodeficiency (HP:0005387)1.76928260
130Broad distal phalanx of finger (HP:0009836)1.76786868
131Dysostosis multiplex (HP:0000943)1.76561234
132Emphysema (HP:0002097)1.76257170
133Abnormal mitochondria in muscle tissue (HP:0008316)1.76066477
134Cholelithiasis (HP:0001081)1.75900699
135Increased serum lactate (HP:0002151)1.75552116
136Prolonged partial thromboplastin time (HP:0003645)1.75360611
137Mitochondrial inheritance (HP:0001427)1.75021859
138Increased CSF lactate (HP:0002490)1.74908881
139Vertebral arch anomaly (HP:0008438)1.74632652
140Granulocytopenia (HP:0001913)1.74397715
141Ectopia lentis (HP:0001083)1.74212694
142Chronic mucocutaneous candidiasis (HP:0002728)1.72409164
143Recurrent cutaneous fungal infections (HP:0011370)1.72409164
144Dislocated radial head (HP:0003083)1.72386744
145Proximal placement of thumb (HP:0009623)1.71820580
146Epiphyseal stippling (HP:0010655)1.71602465
147Joint swelling (HP:0001386)1.71470301
148Abnormality of the acetabulum (HP:0003170)1.71337767
149Abnormality of the alveolar ridges (HP:0006477)1.71184790
150Deviation of the hallux (HP:0010051)1.71151180
151Trismus (HP:0000211)1.70501071
152Testicular atrophy (HP:0000029)1.69765580
153Microretrognathia (HP:0000308)1.69591642
154Cerebral palsy (HP:0100021)1.69278763
155Irregular epiphyses (HP:0010582)1.69207754
156Broad face (HP:0000283)1.68711555
157Abnormality of methionine metabolism (HP:0010901)1.68502799
158Increased intramyocellular lipid droplets (HP:0012240)1.67574199
159Ulnar bowing (HP:0003031)1.66631406
160Thoracolumbar scoliosis (HP:0002944)1.66283926
161Hemorrhage of the eye (HP:0011885)1.66171212
162Hypercholesterolemia (HP:0003124)1.66161365
163Vascular tortuosity (HP:0004948)1.66155388
164Interstitial pulmonary disease (HP:0006530)1.65627224
165Hallux valgus (HP:0001822)1.65615999
166Mesangial abnormality (HP:0001966)1.65280950
167Abnormality of the 4th metacarpal (HP:0010012)1.65259562
168Recurrent abscess formation (HP:0002722)1.64959790
169Abnormality of the fingertips (HP:0001211)1.64804513
170Dicarboxylic aciduria (HP:0003215)1.64733000
171Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64733000
172Hypoplasia of the thymus (HP:0000778)1.64299325
173Deviation of the thumb (HP:0009603)1.64176756
174Agammaglobulinemia (HP:0004432)1.64047584
175Abnormality of the pancreatic islet cells (HP:0006476)1.63982305
176Abnormality of endocrine pancreas physiology (HP:0012093)1.63982305
177Short nail (HP:0001799)1.63537988
178Increased muscle lipid content (HP:0009058)1.63117690
179Abnormality of the radial head (HP:0003995)1.63088411
180Adrenal hypoplasia (HP:0000835)1.63062789
181Squamous cell carcinoma (HP:0002860)1.62683107
182Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62519212
183Abnormality of polysaccharide metabolism (HP:0011012)1.62519212
184Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62519212
185Exercise intolerance (HP:0003546)1.61708153
186Slender build (HP:0001533)1.61467248
187Distal upper limb amyotrophy (HP:0007149)1.61409899
188Meningitis (HP:0001287)1.61178031
189Mitral regurgitation (HP:0001653)1.61152018
190Increased connective tissue (HP:0009025)1.60123688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.23485870
2VRK24.60893091
3EEF2K3.41780149
4BCKDK3.31015239
5EPHA22.77333018
6MAP4K12.68710757
7MAP4K22.51636022
8TRIB32.31923742
9STK102.28160625
10LRRK22.25541538
11SMG12.14414977
12SIK32.08706253
13KDR2.07712310
14LIMK12.05600475
15TEC1.93249562
16BMX1.89940826
17MAPKAPK31.87279949
18TTN1.85306436
19PKN21.82227362
20TRPM71.80131846
21CDC71.80085075
22RPS6KA41.74782719
23TYK21.74232312
24MAP3K101.72135405
25SRPK11.70934755
26TGFBR11.70127196
27JAK31.64954033
28IRAK31.59882705
29NEK21.55816771
30TRIM281.53415755
31CDK121.51009954
32ERN11.50834429
33TSSK61.50488178
34ZAP701.50244878
35DAPK11.49619437
36CDK191.38145972
37SIK21.33434267
38RPS6KB21.33085354
39NME21.30967409
40CDK81.28181560
41CLK11.27030895
42MST1R1.26506644
43ACVR1B1.25136759
44PLK41.21636728
45PAK41.18746130
46PDGFRA1.17812618
47BLK1.16773576
48NLK1.16605225
49MAP2K31.16541099
50TGFBR21.12493797
51BUB11.10636855
52FGFR41.09247935
53LMTK21.08770307
54PASK1.07267780
55WEE11.07237557
56MAP2K61.06520206
57JAK11.06221573
58ICK1.06185776
59VRK11.06044846
60GRK61.05520997
61FGFR31.05427375
62BTK1.04643824
63TXK1.03435627
64NME11.03386687
65TBK11.03016826
66CSNK1G31.02486633
67MAPK111.00727202
68CDK90.99441437
69MAP3K80.97347925
70ERBB30.94986147
71KIT0.94224911
72PTK60.93696331
73ITK0.87493175
74CSF1R0.87067357
75FLT30.86608276
76PIM20.86249615
77IKBKB0.86004040
78TESK20.85646210
79PIM10.85151925
80CSNK1A1L0.80897127
81CDK40.80582126
82BCR0.79536437
83PAK20.78692657
84TNK20.78593427
85PBK0.78354652
86CDK60.77853284
87AURKA0.76446911
88DMPK0.75341445
89HCK0.73611008
90CDK70.73223625
91IKBKE0.72558789
92TLK10.72551621
93LATS20.70989251
94CAMK1D0.69911450
95MST40.69176637
96MTOR0.69114258
97ARAF0.68350294
98NUAK10.68103623
99RPS6KL10.66404466
100RPS6KC10.66404466
101RPS6KA60.65202484
102CHUK0.64886079
103CSK0.64578222
104SIK10.63485270
105BRSK20.61797062
106LCK0.61484571
107STK30.61430293
108SCYL20.61106092
109DYRK1B0.60561676
110NEK10.59765023
111MAP2K70.58415565
112STK40.58107345
113PTK20.57866790
114MKNK10.57397831
115MAP3K110.57110278
116ZAK0.55848329
117EIF2AK10.55764129
118MAPKAPK20.55362884
119MAP3K60.54535923
120PDGFRB0.53612232
121PDK20.53387209
122PRKD20.53154607
123TAOK20.52363375
124MAP3K140.51875986
125MET0.51329471
126EPHB20.51108986
127AURKB0.50500534
128ATR0.49824630
129MAP2K20.49223768
130IRAK40.48112634
131MAP3K50.46496232
132PLK10.46292786
133CSNK1G10.45373777
134BRSK10.44669998
135STK160.44498979
136SYK0.44460059
137EPHA30.44181588
138EPHB10.43620148
139PRKCI0.41732582
140MAP3K30.41706855
141TESK10.40866078
142ALK0.40389343
143RIPK10.39546492
144TAF10.35751197
145HIPK20.35533319
146CDK140.34589413
147ABL20.33017067
148PAK10.32636864
149EIF2AK20.32356441

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.67142554
2DNA replication_Homo sapiens_hsa030302.65610650
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46939647
4Biosynthesis of amino acids_Homo sapiens_hsa012302.29940618
5Fatty acid elongation_Homo sapiens_hsa000622.29598965
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24144651
7Primary immunodeficiency_Homo sapiens_hsa053402.13972234
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.02639820
9Mismatch repair_Homo sapiens_hsa034301.93815238
10Leishmaniasis_Homo sapiens_hsa051401.85369116
11Fructose and mannose metabolism_Homo sapiens_hsa000511.83833440
12Cell cycle_Homo sapiens_hsa041101.81252808
13N-Glycan biosynthesis_Homo sapiens_hsa005101.80266053
14Carbon metabolism_Homo sapiens_hsa012001.79227606
15Galactose metabolism_Homo sapiens_hsa000521.77930169
16Spliceosome_Homo sapiens_hsa030401.76195789
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73448124
18Antigen processing and presentation_Homo sapiens_hsa046121.72633212
19One carbon pool by folate_Homo sapiens_hsa006701.71979389
20Ribosome_Homo sapiens_hsa030101.71548012
21Adherens junction_Homo sapiens_hsa045201.68360859
22p53 signaling pathway_Homo sapiens_hsa041151.62902381
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.61290313
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.60954657
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59820834
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59390897
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.59323185
28Shigellosis_Homo sapiens_hsa051311.59021958
29Herpes simplex infection_Homo sapiens_hsa051681.55298568
30Small cell lung cancer_Homo sapiens_hsa052221.51558020
31HTLV-I infection_Homo sapiens_hsa051661.51527262
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.51251950
33Measles_Homo sapiens_hsa051621.51012361
34Chronic myeloid leukemia_Homo sapiens_hsa052201.48980115
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48503389
36Base excision repair_Homo sapiens_hsa034101.46250365
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45339267
38Sulfur relay system_Homo sapiens_hsa041221.41940503
39B cell receptor signaling pathway_Homo sapiens_hsa046621.40289943
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39671310
41RNA transport_Homo sapiens_hsa030131.39242208
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.37634317
43MicroRNAs in cancer_Homo sapiens_hsa052061.37180871
44Hepatitis B_Homo sapiens_hsa051611.34232373
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32914439
46Glutathione metabolism_Homo sapiens_hsa004801.32330828
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32182550
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32096649
49Viral carcinogenesis_Homo sapiens_hsa052031.31438413
50Toxoplasmosis_Homo sapiens_hsa051451.31067252
51Focal adhesion_Homo sapiens_hsa045101.29014540
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28629398
53Nucleotide excision repair_Homo sapiens_hsa034201.27600396
54Hematopoietic cell lineage_Homo sapiens_hsa046401.27131877
55Acute myeloid leukemia_Homo sapiens_hsa052211.25426269
56Osteoclast differentiation_Homo sapiens_hsa043801.22807816
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22593028
58Apoptosis_Homo sapiens_hsa042101.21337322
59T cell receptor signaling pathway_Homo sapiens_hsa046601.21006917
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20503408
61Epstein-Barr virus infection_Homo sapiens_hsa051691.20153670
62Homologous recombination_Homo sapiens_hsa034401.19996686
63Proteoglycans in cancer_Homo sapiens_hsa052051.19111828
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17213819
65Malaria_Homo sapiens_hsa051441.15964719
66Viral myocarditis_Homo sapiens_hsa054161.15265812
67Steroid biosynthesis_Homo sapiens_hsa001001.14957018
68Pancreatic cancer_Homo sapiens_hsa052121.14793710
69ECM-receptor interaction_Homo sapiens_hsa045121.14103187
70Platelet activation_Homo sapiens_hsa046111.12974011
71Jak-STAT signaling pathway_Homo sapiens_hsa046301.12828963
72Thyroid cancer_Homo sapiens_hsa052161.10083387
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09064502
74TNF signaling pathway_Homo sapiens_hsa046681.07627499
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06459461
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05702588
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04494712
78TGF-beta signaling pathway_Homo sapiens_hsa043501.04290766
79HIF-1 signaling pathway_Homo sapiens_hsa040661.02280813
80Colorectal cancer_Homo sapiens_hsa052101.01021994
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01004804
82RNA degradation_Homo sapiens_hsa030181.00413554
83Vibrio cholerae infection_Homo sapiens_hsa051101.00029089
84Legionellosis_Homo sapiens_hsa051340.97778422
85Non-homologous end-joining_Homo sapiens_hsa034500.97112518
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95402036
87Notch signaling pathway_Homo sapiens_hsa043300.94471628
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94395004
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.94251219
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93791447
91Fatty acid metabolism_Homo sapiens_hsa012120.91697621
92Bladder cancer_Homo sapiens_hsa052190.91138310
93Prostate cancer_Homo sapiens_hsa052150.90791377
94Peroxisome_Homo sapiens_hsa041460.90706894
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87591092
96Influenza A_Homo sapiens_hsa051640.84819848
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83970862
98Purine metabolism_Homo sapiens_hsa002300.83459352
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83326429
100Pentose phosphate pathway_Homo sapiens_hsa000300.82310337
101Pathways in cancer_Homo sapiens_hsa052000.81143628
102Salmonella infection_Homo sapiens_hsa051320.79400969
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78909964
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77047029
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76192520
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74351713
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74035217
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73697982
109Tuberculosis_Homo sapiens_hsa051520.72977021
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72946558
111Pertussis_Homo sapiens_hsa051330.72543572
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71746240
113Proteasome_Homo sapiens_hsa030500.71096088
114Pyrimidine metabolism_Homo sapiens_hsa002400.70140715
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69846232
116Chemokine signaling pathway_Homo sapiens_hsa040620.69631875
117Amoebiasis_Homo sapiens_hsa051460.69447220
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68985651
119Graft-versus-host disease_Homo sapiens_hsa053320.68887805
120Fanconi anemia pathway_Homo sapiens_hsa034600.68791208
121Rap1 signaling pathway_Homo sapiens_hsa040150.68204670
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.67208866
123RNA polymerase_Homo sapiens_hsa030200.63197541
124mRNA surveillance pathway_Homo sapiens_hsa030150.62651292
125Pyruvate metabolism_Homo sapiens_hsa006200.61938337
126Endometrial cancer_Homo sapiens_hsa052130.61770018
127Hepatitis C_Homo sapiens_hsa051600.61732978
128Non-small cell lung cancer_Homo sapiens_hsa052230.61002092
129Lysosome_Homo sapiens_hsa041420.60873273
130FoxO signaling pathway_Homo sapiens_hsa040680.60532761
131Metabolic pathways_Homo sapiens_hsa011000.60175396
132Folate biosynthesis_Homo sapiens_hsa007900.59983801
133Allograft rejection_Homo sapiens_hsa053300.59505328
134Systemic lupus erythematosus_Homo sapiens_hsa053220.59426040
135Complement and coagulation cascades_Homo sapiens_hsa046100.59257034
136Hippo signaling pathway_Homo sapiens_hsa043900.58966935
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.58634721
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.57145282
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56898364
140Protein export_Homo sapiens_hsa030600.55616256
141Basal transcription factors_Homo sapiens_hsa030220.51096741
142VEGF signaling pathway_Homo sapiens_hsa043700.50724163
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50115390
144Parkinsons disease_Homo sapiens_hsa050120.49523795
145Endocytosis_Homo sapiens_hsa041440.47641161
146Fat digestion and absorption_Homo sapiens_hsa049750.45757057
147Oxidative phosphorylation_Homo sapiens_hsa001900.45359801
148Lysine degradation_Homo sapiens_hsa003100.45253055
149Propanoate metabolism_Homo sapiens_hsa006400.39906414
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37698132
151Vitamin digestion and absorption_Homo sapiens_hsa049770.36958753
152Huntingtons disease_Homo sapiens_hsa050160.35518351
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32988448

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