CPNE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.87136678
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04636999
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.04636999
4neutrophil activation involved in immune response (GO:0002283)4.87866192
5ribosomal small subunit assembly (GO:0000028)4.82463938
6antigen processing and presentation of endogenous antigen (GO:0019883)4.68936151
7definitive hemopoiesis (GO:0060216)4.50126606
8response to interferon-beta (GO:0035456)4.46192814
9regulation of T-helper 1 cell differentiation (GO:0045625)4.41169585
10positive regulation of natural killer cell differentiation (GO:0032825)4.27156375
11response to peptidoglycan (GO:0032494)4.26770800
12response to interferon-alpha (GO:0035455)4.13576542
13antigen processing and presentation via MHC class Ib (GO:0002475)4.08383180
14NIK/NF-kappaB signaling (GO:0038061)4.04861180
15Arp2/3 complex-mediated actin nucleation (GO:0034314)4.01199894
16negative regulation of erythrocyte differentiation (GO:0045647)3.97209565
17neutrophil activation (GO:0042119)3.87117332
18myeloid dendritic cell activation (GO:0001773)3.83163477
19barbed-end actin filament capping (GO:0051016)3.81366348
20positive regulation of gamma-delta T cell activation (GO:0046645)3.77707991
21myeloid dendritic cell differentiation (GO:0043011)3.73886482
22granulocyte activation (GO:0036230)3.73790675
23negative regulation of phagocytosis (GO:0050765)3.67980562
24platelet dense granule organization (GO:0060155)3.66174658
25negative regulation of viral genome replication (GO:0045071)3.63769433
26positive regulation of B cell differentiation (GO:0045579)3.63064798
27defense response to protozoan (GO:0042832)3.58277596
28response to muramyl dipeptide (GO:0032495)3.55207009
29endothelium development (GO:0003158)3.49084149
30respiratory burst (GO:0045730)3.49045924
31type I interferon signaling pathway (GO:0060337)3.46449412
32cellular response to type I interferon (GO:0071357)3.46449412
33response to type I interferon (GO:0034340)3.45144027
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.44734660
35modulation by symbiont of host immune response (GO:0052553)3.44734660
36positive regulation by symbiont of host defense response (GO:0052509)3.44734660
37modulation by symbiont of host defense response (GO:0052031)3.44734660
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.44734660
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.44734660
40immunoglobulin mediated immune response (GO:0016064)3.43821657
41response to protozoan (GO:0001562)3.39631697
42neutrophil mediated immunity (GO:0002446)3.37805694
43regulation of natural killer cell differentiation (GO:0032823)3.34098746
44stress fiber assembly (GO:0043149)3.31713655
45positive regulation of antigen processing and presentation (GO:0002579)3.30266332
46dendritic cell differentiation (GO:0097028)3.28562695
47myeloid cell activation involved in immune response (GO:0002275)3.27332773
48T-helper 1 type immune response (GO:0042088)3.23879025
49necroptotic process (GO:0070266)3.21678923
50interferon-gamma-mediated signaling pathway (GO:0060333)3.20627355
51actin nucleation (GO:0045010)3.19268475
52regulation of necroptotic process (GO:0060544)3.17832147
53postsynaptic membrane organization (GO:0001941)3.17713816
54endosome to melanosome transport (GO:0035646)3.16088015
55endosome to pigment granule transport (GO:0043485)3.16088015
56regulation of RIG-I signaling pathway (GO:0039535)3.09039771
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08481429
58secretory granule organization (GO:0033363)3.07354989
59response to fungus (GO:0009620)3.05472108
60megakaryocyte development (GO:0035855)3.05307173
61positive regulation of natural killer cell activation (GO:0032816)3.03942041
62positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.03071169
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03017724
64cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.02123812
65adenosine receptor signaling pathway (GO:0001973)3.00601162
66mast cell activation (GO:0045576)2.99141602
67regulation of necrotic cell death (GO:0010939)2.98807003
68positive regulation of macrophage differentiation (GO:0045651)2.98391180
69myeloid leukocyte mediated immunity (GO:0002444)2.97860750
70leukocyte degranulation (GO:0043299)2.97163412
71positive regulation of interferon-alpha production (GO:0032727)2.94725450
72execution phase of apoptosis (GO:0097194)2.94386184
73regulation of antigen processing and presentation (GO:0002577)2.94118317
74production of molecular mediator involved in inflammatory response (GO:0002532)2.92103302
75cellular response to interferon-beta (GO:0035458)2.92073540
76negative regulation of interleukin-17 production (GO:0032700)2.92056694
77mature B cell differentiation involved in immune response (GO:0002313)2.90166829
78angiogenesis involved in wound healing (GO:0060055)2.89818546
79positive regulation of T-helper cell differentiation (GO:0045624)2.86072252
80regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.86030727
81response to host immune response (GO:0052572)2.85907602
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85907602
83leukocyte mediated cytotoxicity (GO:0001909)2.85864170
84regulation of erythrocyte differentiation (GO:0045646)2.85484163
85negative regulation of blood vessel endothelial cell migration (GO:0043537)2.84772593
86B cell mediated immunity (GO:0019724)2.84569249
87macrophage activation involved in immune response (GO:0002281)2.84240424
88regulation of dendritic cell antigen processing and presentation (GO:0002604)2.83858951
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83307489
90negative regulation of T-helper cell differentiation (GO:0045623)2.83307489
91myeloid leukocyte activation (GO:0002274)2.82491565
92regulation of natural killer cell activation (GO:0032814)2.81412252
93regulation of mast cell activation (GO:0033003)2.80814157
94regulation of hypersensitivity (GO:0002883)2.80479249
95lymph vessel development (GO:0001945)2.80065853
96regulation of interferon-alpha production (GO:0032647)2.79547686
97regulation of interferon-beta biosynthetic process (GO:0045357)2.77969390
98cellular response to thyroid hormone stimulus (GO:0097067)2.76304024
99regulation of mast cell degranulation (GO:0043304)2.75797894
100negative regulation of bone mineralization (GO:0030502)2.75617010
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74339899
102leukocyte aggregation (GO:0070486)2.73345986
103Notch signaling involved in heart development (GO:0061314)2.72951325
104reactive oxygen species biosynthetic process (GO:1903409)2.71964311
105regulation of interleukin-17 production (GO:0032660)2.71222030
106central nervous system myelination (GO:0022010)2.70975594
107axon ensheathment in central nervous system (GO:0032291)2.70975594
108chondroitin sulfate catabolic process (GO:0030207)2.70926493
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70899200
110mannose metabolic process (GO:0006013)2.70705668
111positive regulation of vasculogenesis (GO:2001214)2.69382538
112mature B cell differentiation (GO:0002335)2.68752832
113regulation of B cell differentiation (GO:0045577)2.68557122
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.67155327
115regulation of chemokine biosynthetic process (GO:0045073)2.67013464
116semaphorin-plexin signaling pathway (GO:0071526)2.66478606
117regulation of vasculogenesis (GO:2001212)2.64478679
118negative regulation of granulocyte differentiation (GO:0030853)2.64416905
119vascular endothelial growth factor signaling pathway (GO:0038084)2.63307463
120dermatan sulfate metabolic process (GO:0030205)2.62626920
121glial cell migration (GO:0008347)2.60159844
122oligodendrocyte differentiation (GO:0048709)2.59402690
123dermatan sulfate biosynthetic process (GO:0030208)2.58212745
124regulation of cholesterol storage (GO:0010885)2.54065546
125chondroitin sulfate biosynthetic process (GO:0030206)2.53749798
126L-amino acid import (GO:0043092)2.52477878
127retina vasculature morphogenesis in camera-type eye (GO:0061299)2.50581626
128positive regulation of extracellular matrix organization (GO:1903055)2.49723466
129astrocyte differentiation (GO:0048708)2.49172025
130regulation of leukocyte degranulation (GO:0043300)2.48054757
131cell-cell junction maintenance (GO:0045217)2.47641495
132positive regulation of cellular amide metabolic process (GO:0034250)2.47447653
133negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46497269
134glycosphingolipid catabolic process (GO:0046479)2.45686078
135glomerular filtration (GO:0003094)2.42925345
136peptidyl-tyrosine autophosphorylation (GO:0038083)2.42820980
137regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.41567270
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39686174
139phagocytosis, recognition (GO:0006910)2.39163176
140adhesion of symbiont to host cell (GO:0044650)2.38758224
141virion attachment to host cell (GO:0019062)2.38758224
142regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38389842
143regulation of macrophage cytokine production (GO:0010935)2.36233619
144positive regulation of receptor recycling (GO:0001921)2.35896769
145regulation of synapse structural plasticity (GO:0051823)2.34953272
146regulation of ARF GTPase activity (GO:0032312)2.34422695
147regulation of early endosome to late endosome transport (GO:2000641)2.34261084
148renal filtration (GO:0097205)2.34069910
149heart valve formation (GO:0003188)2.33197352
150endothelial cell chemotaxis (GO:0035767)2.32225931
151positive regulation of protein dephosphorylation (GO:0035307)2.31056480
152negative regulation of interleukin-8 production (GO:0032717)2.30722724
153positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29863357
154amino acid import (GO:0043090)2.26670571
155negative regulation of interleukin-12 production (GO:0032695)2.26580070
156response to laminar fluid shear stress (GO:0034616)2.23066952
157cortical actin cytoskeleton organization (GO:0030866)2.21769522
158regulation of macrophage chemotaxis (GO:0010758)2.19607211
159astrocyte development (GO:0014002)2.19471954
160positive regulation of lipid kinase activity (GO:0090218)2.19000056
161cellular extravasation (GO:0045123)2.18264590
162cGMP-mediated signaling (GO:0019934)2.18024552
163blood vessel maturation (GO:0001955)2.16997154
164cortical cytoskeleton organization (GO:0030865)2.16816230
165negative regulation of endothelial cell migration (GO:0010596)2.16161987
166pinocytosis (GO:0006907)2.15956777
167establishment of endothelial barrier (GO:0061028)2.15773000
168cellular response to epinephrine stimulus (GO:0071872)2.15458686
169protein localization to endosome (GO:0036010)2.14758818
170endothelial cell differentiation (GO:0045446)2.12586310
171adhesion of symbiont to host (GO:0044406)2.11477117
172glycolipid catabolic process (GO:0019377)2.10865023
173macrophage activation (GO:0042116)2.10555291
174sodium ion export (GO:0071436)2.10223656
175basement membrane organization (GO:0071711)2.10192255
176cAMP biosynthetic process (GO:0006171)2.09939380
177camera-type eye morphogenesis (GO:0048593)2.09327055
178apoptotic cell clearance (GO:0043277)2.08675311
179actin filament bundle assembly (GO:0051017)2.05777280
180actin filament bundle organization (GO:0061572)2.05777280
181low-density lipoprotein particle clearance (GO:0034383)2.05768614
182white fat cell differentiation (GO:0050872)2.04807890
183detection of other organism (GO:0098543)2.04309028
184positive regulation of leukocyte degranulation (GO:0043302)2.03924304
185G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.03015511
186positive regulation of vascular permeability (GO:0043117)2.02210869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.18970017
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.60916653
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.51052134
4SCL_19346495_ChIP-Seq_HPC-7_Human4.26138948
5MYB_21317192_ChIP-Seq_ERMYB_Mouse4.21504386
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.19230300
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.88127001
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.76501791
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.42699194
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38908553
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.25083161
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.20220376
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09253292
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.08228303
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.81565572
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.78836289
17VDR_21846776_ChIP-Seq_THP-1_Human2.68275490
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64934011
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60225609
20VDR_24763502_ChIP-Seq_THP-1_Human2.59069364
21SPI1_23547873_ChIP-Seq_NB4_Human2.51983948
22LXR_22292898_ChIP-Seq_THP-1_Human2.49353158
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.44974060
24E2F7_22180533_ChIP-Seq_HELA_Human2.44095706
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41618484
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38001379
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37662234
28* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29022820
29* RUNX1_22412390_ChIP-Seq_EML_Mouse2.25357472
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.22710473
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21252599
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11800440
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.08012718
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07283660
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04773141
36MYB_26560356_Chip-Seq_TH2_Human1.99172373
37MAF_26560356_Chip-Seq_TH1_Human1.96834528
38DROSHA_22980978_ChIP-Seq_HELA_Human1.93664444
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92668160
40SPI1_23127762_ChIP-Seq_K562_Human1.89791246
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89020799
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.87089671
43* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85448685
44KDM2B_26808549_Chip-Seq_K562_Human1.85248641
45GATA1_22025678_ChIP-Seq_K562_Human1.78456643
46TCF7_22412390_ChIP-Seq_EML_Mouse1.78020247
47RUNX_20019798_ChIP-Seq_JUKART_Human1.74820654
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73754153
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72805375
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.72331074
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.72323854
52MYB_26560356_Chip-Seq_TH1_Human1.66632211
53MYC_22102868_ChIP-Seq_BL_Human1.65621730
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.65531189
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64643609
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64524704
57PU_27001747_Chip-Seq_BMDM_Mouse1.63384381
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.62652309
59EZH2_22144423_ChIP-Seq_EOC_Human1.61530147
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.61179192
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56854154
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55499499
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.53778727
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53573147
65VDR_24787735_ChIP-Seq_THP-1_Human1.48871688
66RACK7_27058665_Chip-Seq_MCF-7_Human1.48320223
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45715292
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45524804
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45318951
70* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45202322
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43771761
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.41951650
73UTX_26944678_Chip-Seq_JUKART_Human1.41552766
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.40339086
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39857202
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39212630
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38336578
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37851584
79* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37419474
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.36280228
81* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34720816
82RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34188709
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34188709
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31503159
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31266950
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29296375
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.28930256
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28298356
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26599813
90* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25569085
91* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24185350
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24164021
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22569664
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22486182
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20806770
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20800327
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.20263463
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19062752
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17913801
100* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17591400
101SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17279959
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16762744
103MAF_26560356_Chip-Seq_TH2_Human1.16601351
104P68_20966046_ChIP-Seq_HELA_Human1.16530614
105SMC4_20622854_ChIP-Seq_HELA_Human1.16468839
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16235792
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16155681
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13970775
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.13933598
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13263019
111* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12875681
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12825488
113* GATA3_27048872_Chip-Seq_THYMUS_Human1.12345449
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11802560
115SA1_27219007_Chip-Seq_ERYTHROID_Human1.11413021
116ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10982018
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10641642
118* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10499999
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10469828
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.10069704
121KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09928678
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09721016
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08321492
124* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07868640
125CLOCK_20551151_ChIP-Seq_293T_Human1.07849833
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06635572
127* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06133363
128* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04922614
129CTCF_27219007_Chip-Seq_Bcells_Human1.04679606
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04633994
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03514724
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02363159
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01952072
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99974660
135EGR1_19032775_ChIP-ChIP_M12_Human0.99960167
136* GATA2_19941826_ChIP-Seq_K562_Human0.99901521
137GATA3_26560356_Chip-Seq_TH2_Human0.99862796
138* TP53_23651856_ChIP-Seq_MEFs_Mouse0.99773417
139CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99323773
140TP63_22573176_ChIP-Seq_HFKS_Human0.99218299
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98693794
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98376832
143* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98055308
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.97854410
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97618183
146* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97431931
147* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96857325
148* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96857325
149EED_16625203_ChIP-ChIP_MESCs_Mouse0.96269132
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94986557
151IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94637769
152TP63_17297297_ChIP-ChIP_HaCaT_Human0.93660750
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92886751
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92555696
155* KDM2B_26808549_Chip-Seq_DND41_Human0.92076376
156SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90933794
157GATA1_19941826_ChIP-Seq_K562_Human0.89653619
158KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87812908
159* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87735641
160RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84214589
161PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80884771
162ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79539627
163NCOR1_26117541_ChIP-Seq_K562_Human0.78053749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.17789185
2MP0003705_abnormal_hypodermis_morpholog3.41032435
3MP0003436_decreased_susceptibility_to3.32783802
4MP0009785_altered_susceptibility_to3.30560794
5MP0000685_abnormal_immune_system3.26594751
6MP0010368_abnormal_lymphatic_system3.08766688
7MP0002148_abnormal_hypersensitivity_rea3.05677596
8MP0003724_increased_susceptibility_to3.05569518
9MP0002419_abnormal_innate_immunity2.84340927
10MP0001545_abnormal_hematopoietic_system2.83387168
11MP0005397_hematopoietic_system_phenotyp2.83387168
12MP0005464_abnormal_platelet_physiology2.79177609
13MP0003303_peritoneal_inflammation2.77909993
14MP0005025_abnormal_response_to2.75408824
15MP0005000_abnormal_immune_tolerance2.62449161
16MP0002396_abnormal_hematopoietic_system2.54939968
17MP0002166_altered_tumor_susceptibility2.48467153
18MP0003690_abnormal_glial_cell2.40224834
19MP0005671_abnormal_response_to2.36156658
20MP0004808_abnormal_hematopoietic_stem2.35418020
21MP0005174_abnormal_tail_pigmentation2.34350502
22MP0002452_abnormal_antigen_presenting2.30153931
23MP0004510_myositis2.28839156
24MP0001853_heart_inflammation2.26702718
25MP0009278_abnormal_bone_marrow2.25073656
26MP0002723_abnormal_immune_serum2.16648615
27MP0001790_abnormal_immune_system2.14230506
28MP0005387_immune_system_phenotype2.14230506
29MP0001800_abnormal_humoral_immune2.13331089
30MP0001819_abnormal_immune_cell2.12132748
31MP0001879_abnormal_lymphatic_vessel2.11514960
32MP0002420_abnormal_adaptive_immunity2.11377513
33MP0003329_amyloid_beta_deposits2.10994079
34MP0002006_tumorigenesis2.08459572
35MP0005409_darkened_coat_color2.03654271
36MP0001533_abnormal_skeleton_physiology1.89579883
37MP0000920_abnormal_myelination1.88673754
38MP0002877_abnormal_melanocyte_morpholog1.84658983
39MP0002398_abnormal_bone_marrow1.84620508
40MP0001348_abnormal_lacrimal_gland1.82142500
41MP0000465_gastrointestinal_hemorrhage1.81258108
42MP0003183_abnormal_peptide_metabolism1.79440395
43MP0002254_reproductive_system_inflammat1.78776158
44MP0001849_ear_inflammation1.78640368
45MP0000343_altered_response_to1.78285520
46MP0000716_abnormal_immune_system1.70124433
47MP0005595_abnormal_vascular_smooth1.69625287
48MP0010155_abnormal_intestine_physiology1.67958514
49MP0002405_respiratory_system_inflammati1.67015905
50MP0002653_abnormal_ependyma_morphology1.65471074
51MP0003172_abnormal_lysosome_physiology1.62454697
52MP0003075_altered_response_to1.61454541
53MP0001845_abnormal_inflammatory_respons1.60851970
54MP0001873_stomach_inflammation1.60710820
55MP0005058_abnormal_lysosome_morphology1.59280518
56MP0005666_abnormal_adipose_tissue1.57489941
57MP0003300_gastrointestinal_ulcer1.57308801
58MP0009764_decreased_sensitivity_to1.54247521
59MP0004859_abnormal_synaptic_plasticity1.50597587
60MP0004130_abnormal_muscle_cell1.49548591
61MP0003634_abnormal_glial_cell1.47761337
62MP0002429_abnormal_blood_cell1.46984155
63MP0005670_abnormal_white_adipose1.46458707
64MP0009333_abnormal_splenocyte_physiolog1.45306309
65MP0000689_abnormal_spleen_morphology1.44570506
66MP0008469_abnormal_protein_level1.43586450
67MP0000490_abnormal_crypts_of1.43447765
68MP0004185_abnormal_adipocyte_glucose1.42293089
69MP0006082_CNS_inflammation1.41402223
70MP0002722_abnormal_immune_system1.41008012
71MP0000858_altered_metastatic_potential1.40383567
72MP0002163_abnormal_gland_morphology1.37833873
73MP0000767_abnormal_smooth_muscle1.35259854
74MP0005310_abnormal_salivary_gland1.32565458
75MP0004947_skin_inflammation1.31763391
76MP0005076_abnormal_cell_differentiation1.31288307
77MP0004885_abnormal_endolymph1.30366637
78MP0003656_abnormal_erythrocyte_physiolo1.23312604
79MP0003186_abnormal_redox_activity1.12835295
80MP0003448_altered_tumor_morphology1.12581477
81MP0009053_abnormal_anal_canal1.11231014
82MP0002095_abnormal_skin_pigmentation1.10302151
83MP0002736_abnormal_nociception_after1.10017465
84MP0001986_abnormal_taste_sensitivity1.09835512
85MP0005023_abnormal_wound_healing1.09701870
86MP0010307_abnormal_tumor_latency1.09201780
87MP0003279_aneurysm1.07431745
88MP0003763_abnormal_thymus_physiology1.05430280
89MP0002896_abnormal_bone_mineralization1.05133035
90MP0005375_adipose_tissue_phenotype1.04793721
91MP0005257_abnormal_intraocular_pressure1.04145471
92MP0004883_abnormal_blood_vessel1.03825828
93MP0005388_respiratory_system_phenotype1.03454803
94MP0002133_abnormal_respiratory_system1.03454803
95MP0000569_abnormal_digit_pigmentation1.03208666
96MP0004272_abnormal_basement_membrane1.02771105
97MP0003866_abnormal_defecation1.01497556
98MP0003191_abnormal_cellular_cholesterol1.01492338
99MP0005075_abnormal_melanosome_morpholog0.98395584
100MP0006054_spinal_hemorrhage0.98128537
101MP0002971_abnormal_brown_adipose0.98079347
102MP0003453_abnormal_keratinocyte_physiol0.96974164
103MP0003566_abnormal_cell_adhesion0.96570744
104MP0003136_yellow_coat_color0.96178660
105MP0003633_abnormal_nervous_system0.95653270
106MP0002998_abnormal_bone_remodeling0.95332210
107MP0001663_abnormal_digestive_system0.95292918
108MP0004858_abnormal_nervous_system0.94973851
109MP0005165_increased_susceptibility_to0.94919980
110MP0005166_decreased_susceptibility_to0.94676158
111MP0003632_abnormal_nervous_system0.94339094
112MP0002249_abnormal_larynx_morphology0.94122713
113MP0001958_emphysema0.92899155
114MP0002733_abnormal_thermal_nociception0.92131249
115MP0000015_abnormal_ear_pigmentation0.90439724
116MP0005390_skeleton_phenotype0.90320925
117MP0001970_abnormal_pain_threshold0.89616473
118MP0005167_abnormal_blood-brain_barrier0.88330658
119MP0009379_abnormal_foot_pigmentation0.87152309
120MP0005379_endocrine/exocrine_gland_phen0.86884885
121MP0000703_abnormal_thymus_morphology0.85688289
122MP0009840_abnormal_foam_cell0.82567538
123MP0010352_gastrointestinal_tract_polyps0.82451422
124MP0003943_abnormal_hepatobiliary_system0.81831570
125MP0001851_eye_inflammation0.80516969
126MP0003631_nervous_system_phenotype0.80361650
127MP0006138_congestive_heart_failure0.80249424
128MP0005164_abnormal_response_to0.80236633
129MP0009115_abnormal_fat_cell0.80014799
130MP0001614_abnormal_blood_vessel0.78708473
131MP0001486_abnormal_startle_reflex0.78636848
132MP0000778_abnormal_nervous_system0.78049486
133MP0000249_abnormal_blood_vessel0.77877933
134MP0005508_abnormal_skeleton_morphology0.77382945
135MP0009763_increased_sensitivity_to0.75867725
136MP0003828_pulmonary_edema0.75735226
137MP0003638_abnormal_response/metabolism_0.73858595
138MP0002009_preneoplasia0.73699326
139MP0001968_abnormal_touch/_nociception0.70396036
140MP0003045_fibrosis0.70154941
141MP0000371_diluted_coat_color0.70008294
142MP0003091_abnormal_cell_migration0.69243731
143MP0000026_abnormal_inner_ear0.69228301
144MP0002933_joint_inflammation0.68067348
145MP0008260_abnormal_autophagy0.66781922
146MP0003283_abnormal_digestive_organ0.63890258
147MP0002064_seizures0.63843628
148MP0002019_abnormal_tumor_incidence0.62828830
149MP0008874_decreased_physiological_sensi0.62621918
150MP0002138_abnormal_hepatobiliary_system0.60063443
151MP0001502_abnormal_circadian_rhythm0.59274919
152MP0000604_amyloidosis0.58680975

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.47300802
2Eczematoid dermatitis (HP:0000976)4.96868420
3Recurrent bacterial skin infections (HP:0005406)4.96498769
4Myositis (HP:0100614)4.59267258
5Thrombocytosis (HP:0001894)4.51018574
6Elevated erythrocyte sedimentation rate (HP:0003565)4.44908185
7Chronic otitis media (HP:0000389)4.13234471
8Mediastinal lymphadenopathy (HP:0100721)4.03611830
9Prolonged bleeding time (HP:0003010)3.95058649
10Petechiae (HP:0000967)3.94602068
11Abnormality of macrophages (HP:0004311)3.93196238
12Orchitis (HP:0100796)3.87765248
13Recurrent gram-negative bacterial infections (HP:0005420)3.84781466
14Recurrent fungal infections (HP:0002841)3.61123608
15Systemic lupus erythematosus (HP:0002725)3.53867059
16Neurofibrillary tangles (HP:0002185)3.42967817
17Chronic obstructive pulmonary disease (HP:0006510)3.42625443
18Obstructive lung disease (HP:0006536)3.42625443
19Optic neuritis (HP:0100653)3.38515344
20Retrobulbar optic neuritis (HP:0100654)3.38515344
21Recurrent skin infections (HP:0001581)3.35984978
22Cellulitis (HP:0100658)3.30268365
23Impaired platelet aggregation (HP:0003540)3.16111757
24Abnormal platelet function (HP:0011869)3.16111757
25Increased cerebral lipofuscin (HP:0011813)3.14092810
26Increased neuronal autofluorescent lipopigment (HP:0002074)3.12535570
27Epistaxis (HP:0000421)3.06064569
28Interstitial pulmonary disease (HP:0006530)2.98200815
29Nasal polyposis (HP:0100582)2.97780875
30Obstructive sleep apnea (HP:0002870)2.97079545
31Abnormality of the nasal mucosa (HP:0000433)2.96985818
32Loss of speech (HP:0002371)2.93865485
33Abnormal number of erythroid precursors (HP:0012131)2.91926893
34Recurrent viral infections (HP:0004429)2.90960223
35Periodontitis (HP:0000704)2.90709729
36Abnormality of cells of the erythroid lineage (HP:0012130)2.88350925
37Vertebral compression fractures (HP:0002953)2.86079497
38Autoimmune thrombocytopenia (HP:0001973)2.78873289
39Arterial thrombosis (HP:0004420)2.78528142
40Meningitis (HP:0001287)2.75447546
41Gingival bleeding (HP:0000225)2.74937496
42J-shaped sella turcica (HP:0002680)2.71294680
43Purpura (HP:0000979)2.71080932
44Chronic mucocutaneous candidiasis (HP:0002728)2.69091834
45Recurrent cutaneous fungal infections (HP:0011370)2.69091834
46Cerebral aneurysm (HP:0004944)2.65211260
47Hemiplegia (HP:0002301)2.64888047
48Gingivitis (HP:0000230)2.64058171
49Vasculitis (HP:0002633)2.62611872
50Nuclear cataract (HP:0100018)2.60808687
51Vacuolated lymphocytes (HP:0001922)2.57620157
52Protrusio acetabuli (HP:0003179)2.57179006
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.54787295
54Deformed sella turcica (HP:0002681)2.54431837
55Thoracic kyphosis (HP:0002942)2.52893905
56Mucopolysacchariduria (HP:0008155)2.51882822
57Urinary glycosaminoglycan excretion (HP:0003541)2.51882822
58Action tremor (HP:0002345)2.50717749
59Aplastic anemia (HP:0001915)2.50654507
60Recurrent bronchitis (HP:0002837)2.48798083
61Urticaria (HP:0001025)2.47655031
62Abnormality of the lumbar spine (HP:0100712)2.47049792
63Beaking of vertebral bodies (HP:0004568)2.46539963
64Abnormal platelet volume (HP:0011876)2.45233741
65Cerebral inclusion bodies (HP:0100314)2.45145425
66Reduced antithrombin III activity (HP:0001976)2.43220591
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.43011958
68Hyperacusis (HP:0010780)2.40083454
69Turricephaly (HP:0000262)2.39905732
70Albinism (HP:0001022)2.39626730
71Pulmonary infiltrates (HP:0002113)2.38759541
72Axonal loss (HP:0003447)2.34559039
73Mutism (HP:0002300)2.33927347
74Hemorrhage of the eye (HP:0011885)2.33414935
75Dysostosis multiplex (HP:0000943)2.31462022
76Acute myeloid leukemia (HP:0004808)2.27149975
77Chest pain (HP:0100749)2.27123982
78Arterial tortuosity (HP:0005116)2.26726685
79Stomatitis (HP:0010280)2.25946575
80Polygenic inheritance (HP:0010982)2.25691028
81Abnormality of binocular vision (HP:0011514)2.25587492
82Diplopia (HP:0000651)2.25587492
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24129502
84Abnormality of polysaccharide metabolism (HP:0011012)2.24129502
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24129502
86Mitral regurgitation (HP:0001653)2.24011422
87Abnormality of the thoracic spine (HP:0100711)2.23313489
88Basal ganglia calcification (HP:0002135)2.22882327
89Hypergammaglobulinemia (HP:0010702)2.22762995
90Leukocytosis (HP:0001974)2.20957547
91Increased IgE level (HP:0003212)2.20754400
92Menorrhagia (HP:0000132)2.19066118
93Broad metatarsal (HP:0001783)2.19002751
94IgM deficiency (HP:0002850)2.18151977
95Abnormality of glycolipid metabolism (HP:0010969)2.15840110
96Abnormality of liposaccharide metabolism (HP:0010968)2.15840110
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.15840110
98Papilledema (HP:0001085)2.15662781
99Neoplasm of head and neck (HP:0012288)2.14682144
100Esophageal neoplasm (HP:0100751)2.14682144
101Vascular tortuosity (HP:0004948)2.14179318
102Neuronal loss in central nervous system (HP:0002529)2.12991786
103Increased mean platelet volume (HP:0011877)2.11761912
104Peritonitis (HP:0002586)2.10622333
105Spinal cord lesions (HP:0100561)2.10260934
106Syringomyelia (HP:0003396)2.10260934
107Hemoptysis (HP:0002105)2.09779027
108Annular pancreas (HP:0001734)2.08507372
109Ulnar bowing (HP:0003031)2.08256302
110Shallow orbits (HP:0000586)2.08078445
111Keratoconjunctivitis (HP:0001096)2.07193311
112Apathy (HP:0000741)2.06276044
113Increased variability in muscle fiber diameter (HP:0003557)2.03784258
114Increased serum ferritin (HP:0003281)2.02443730
115Hematochezia (HP:0002573)2.02024341
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01559940
117Segmental peripheral demyelination/remyelination (HP:0003481)2.00806251
118Abnormality of T cell physiology (HP:0011840)2.00676782
119Biconcave vertebral bodies (HP:0004586)1.99775889
120Abnormality of the prostate (HP:0008775)1.99646226
121Bruising susceptibility (HP:0000978)1.99570374
122Myocardial infarction (HP:0001658)1.99295485
123Cervical subluxation (HP:0003308)1.99028280
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98909719
125Onion bulb formation (HP:0003383)1.97708733
126Broad face (HP:0000283)1.97417511
127Osteomyelitis (HP:0002754)1.96476449
128Glomerulonephritis (HP:0000099)1.96453183
129Esophageal varix (HP:0002040)1.95588222
130Conjunctival telangiectasia (HP:0000524)1.95393652
131Spontaneous hematomas (HP:0007420)1.95091509
132Recurrent pneumonia (HP:0006532)1.94525905
133Diminished motivation (HP:0000745)1.94162711
134Thin bony cortex (HP:0002753)1.93828911
135Keratoconjunctivitis sicca (HP:0001097)1.93822454
136Amyloidosis (HP:0011034)1.91884948
137Tetraparesis (HP:0002273)1.90132775
138Radial bowing (HP:0002986)1.88580063
139Supranuclear gaze palsy (HP:0000605)1.88487367
140Polycythemia (HP:0001901)1.87511255
141Abnormality of the diencephalon (HP:0010662)1.86852363
142Disinhibition (HP:0000734)1.86249870
143Bronchomalacia (HP:0002780)1.83198221
144Abnormal eating behavior (HP:0100738)1.79874893
145Insomnia (HP:0100785)1.79813666
146Rapidly progressive (HP:0003678)1.75004851
147Abnormality of the periventricular white matter (HP:0002518)1.73230345
148Hypertriglyceridemia (HP:0002155)1.71780541
149Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71019557
150Short 4th metacarpal (HP:0010044)1.71019557
151Genu recurvatum (HP:0002816)1.70008608
152Hyperparathyroidism (HP:0000843)1.69748389
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.69376038
154Neonatal short-limb short stature (HP:0008921)1.69299869
155Dementia (HP:0000726)1.68538523
156Abnormality of the 4th metacarpal (HP:0010012)1.67567116
157Abnormal vertebral ossification (HP:0100569)1.65544039
158Visceral angiomatosis (HP:0100761)1.64705189
159Disproportionate tall stature (HP:0001519)1.63975551
160Abnormality of skeletal muscle fiber size (HP:0012084)1.62121197
161Pulmonary artery stenosis (HP:0004415)1.61836191
162Tibial bowing (HP:0002982)1.60154405
163Mesangial abnormality (HP:0001966)1.60056614
164Pulmonary hypertension (HP:0002092)1.58977467
165Abnormality of complement system (HP:0005339)1.58214867
166Premature rupture of membranes (HP:0001788)1.56923276
167Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.54565095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.78259602
2KIT3.43129722
3IRAK43.08031185
4MAP3K142.83538261
5PIM22.71062406
6MAP3K122.64791935
7TBK12.57953616
8MUSK2.41447079
9RIPK42.35450812
10NME22.30118759
11MAP4K12.25797079
12MAPK152.23824196
13IKBKB2.21242492
14MATK2.20688790
15JAK32.09138250
16PRPF4B2.04573338
17TYK22.03050714
18IKBKE2.01899833
19BTK1.98730157
20PRKD31.96832896
21TEC1.84011641
22FES1.83820434
23NTRK11.81301429
24BLK1.81153706
25EEF2K1.79434020
26TYRO31.78128022
27MAP3K31.55061113
28TGFBR11.52206745
29IRAK31.49838585
30EPHB11.49407301
31SYK1.48326242
32MARK21.47277848
33TRPM71.45481715
34FLT31.44105695
35LRRK21.42538949
36TRIB31.41281260
37MAP3K131.39688694
38MAP3K111.36864304
39PIM11.36469303
40CSF1R1.35238305
41PDGFRA1.35168382
42TAOK11.35113557
43ERN11.34565336
44PRKG21.33689132
45NTRK31.30852587
46NTRK21.28837314
47DDR21.27691947
48JAK11.25024652
49PTK21.24967390
50EIF2AK31.22580423
51SIK11.22015473
52MAPKAPK51.21705152
53CHUK1.19760739
54ZAP701.16019936
55MAP2K31.13212014
56KSR21.12462859
57CAMKK21.11458036
58TNIK1.10160686
59ICK1.09663446
60TAOK31.09141646
61PTK2B1.08543852
62TNK21.06365023
63PAK61.06330182
64CDC42BPA1.05623558
65PRKD21.02701655
66TGFBR21.01370885
67SMG11.00510160
68HCK1.00191367
69LYN0.98995121
70FGR0.97649806
71GRK60.97637951
72EIF2AK20.94696536
73PDGFRB0.92887231
74PDPK10.92638645
75TXK0.92215558
76FGFR30.91411993
77NEK90.90411415
78PAK40.88661039
79STK160.88645674
80RPS6KA40.86494961
81SCYL20.85990811
82JAK20.85580242
83DMPK0.85350441
84LATS20.84687616
85CAMK1D0.84664841
86LCK0.84021570
87TIE10.82821891
88TESK20.82541236
89NLK0.80017095
90ROCK20.79972541
91MARK10.77628550
92MAPKAPK30.77028902
93CDK80.76176282
94PKN20.75983061
95EPHA30.75902465
96MKNK10.75469988
97MAPK40.74205748
98CAMK1G0.73791405
99PKN10.69510350
100ABL20.68887839
101KSR10.68401224
102CDK190.66689907
103DAPK10.66228545
104PTK60.65649346
105MAP3K60.65472028
106ILK0.65467836
107ROCK10.65169236
108TAOK20.64769509
109RIPK10.62336820
110MYLK0.59564705
111FER0.59406528
112RPS6KA60.59394519
113CAMK2B0.59095128
114SGK30.56948514
115MOS0.56895058
116PRKCD0.56103691
117MAPK70.55760329
118PRKD10.55309372
119ARAF0.54778887
120KDR0.54662238
121CSK0.53976711
122TESK10.53800051
123IRAK20.53792621
124MAPK120.52900089
125RPS6KA20.52897086
126BMX0.52634421
127SIK20.52382058
128MAPKAPK20.51859016
129RET0.49826145
130MTOR0.49815369
131GSK3A0.49355395
132CDK60.47746423
133PNCK0.47356331
134IRAK10.47310967
135RPS6KB20.47103934
136FYN0.46942181
137SRC0.46225361
138CAMKK10.43915854
139RPS6KC10.43644571
140RPS6KL10.43644571
141HIPK20.43324902
142YES10.43193575
143MAP3K80.42936842
144MAP2K10.42498147
145SGK2230.42211896
146SGK4940.42211896
147PIK3CG0.42012107
148LMTK20.41758440
149RPS6KB10.40141616
150MAP3K10.39496890
151WEE10.39494834
152BRSK20.39039923
153ABL10.38193827
154VRK10.37308720
155MAP2K60.36732827
156ALK0.34455573
157STK100.33966769

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.27232893
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31189821
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.30095354
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29864908
5Osteoclast differentiation_Homo sapiens_hsa043802.19410769
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18768352
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13879626
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.09841417
9Pertussis_Homo sapiens_hsa051332.03897285
10Measles_Homo sapiens_hsa051622.00283097
11Asthma_Homo sapiens_hsa053101.92841387
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.92112167
13B cell receptor signaling pathway_Homo sapiens_hsa046621.89561495
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88982115
15Malaria_Homo sapiens_hsa051441.88427377
16Legionellosis_Homo sapiens_hsa051341.82681375
17Allograft rejection_Homo sapiens_hsa053301.82288924
18Notch signaling pathway_Homo sapiens_hsa043301.79767624
19Tuberculosis_Homo sapiens_hsa051521.78982053
20TNF signaling pathway_Homo sapiens_hsa046681.77528480
21DNA replication_Homo sapiens_hsa030301.74283910
22Ribosome_Homo sapiens_hsa030101.73435582
23Shigellosis_Homo sapiens_hsa051311.70007339
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.66439147
25Salmonella infection_Homo sapiens_hsa051321.65027753
26Toxoplasmosis_Homo sapiens_hsa051451.64028580
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62847873
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60593615
29Hematopoietic cell lineage_Homo sapiens_hsa046401.57590983
30Apoptosis_Homo sapiens_hsa042101.56807348
31Prion diseases_Homo sapiens_hsa050201.53749512
32Platelet activation_Homo sapiens_hsa046111.53064900
33Acute myeloid leukemia_Homo sapiens_hsa052211.52205822
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48209932
35Influenza A_Homo sapiens_hsa051641.44205662
36Herpes simplex infection_Homo sapiens_hsa051681.42910369
37Hepatitis B_Homo sapiens_hsa051611.38449635
38Staphylococcus aureus infection_Homo sapiens_hsa051501.38302191
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36959816
40African trypanosomiasis_Homo sapiens_hsa051431.35932084
41Chemokine signaling pathway_Homo sapiens_hsa040621.34163711
42Antigen processing and presentation_Homo sapiens_hsa046121.33246506
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32834738
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32341908
45Graft-versus-host disease_Homo sapiens_hsa053321.26184612
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23728716
47Estrogen signaling pathway_Homo sapiens_hsa049151.20549724
48PPAR signaling pathway_Homo sapiens_hsa033201.19202941
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17791589
50Rheumatoid arthritis_Homo sapiens_hsa053231.17394417
51Chronic myeloid leukemia_Homo sapiens_hsa052201.15128348
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14114003
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.13854601
54Phagosome_Homo sapiens_hsa041451.07035580
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07026082
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06829104
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06828441
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.05048344
59Other glycan degradation_Homo sapiens_hsa005111.04703879
60Renal cell carcinoma_Homo sapiens_hsa052111.02794394
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02604516
62GnRH signaling pathway_Homo sapiens_hsa049121.02429988
63Rap1 signaling pathway_Homo sapiens_hsa040151.01705481
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01686069
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01196955
66Dorso-ventral axis formation_Homo sapiens_hsa043201.00594686
67Primary immunodeficiency_Homo sapiens_hsa053400.99511879
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.99384743
69Lysosome_Homo sapiens_hsa041420.97090653
70Endocytosis_Homo sapiens_hsa041440.95511587
71Caffeine metabolism_Homo sapiens_hsa002320.91114866
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86731356
73ECM-receptor interaction_Homo sapiens_hsa045120.86014532
74Axon guidance_Homo sapiens_hsa043600.84980883
75Cocaine addiction_Homo sapiens_hsa050300.84629159
76Viral myocarditis_Homo sapiens_hsa054160.84296619
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83091065
78Hepatitis C_Homo sapiens_hsa051600.82831222
79Histidine metabolism_Homo sapiens_hsa003400.82785115
80Gastric acid secretion_Homo sapiens_hsa049710.82427567
81Prolactin signaling pathway_Homo sapiens_hsa049170.80603335
82Sphingolipid metabolism_Homo sapiens_hsa006000.80539771
83Morphine addiction_Homo sapiens_hsa050320.80231110
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79429853
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78710984
86Cholinergic synapse_Homo sapiens_hsa047250.76088338
87Adherens junction_Homo sapiens_hsa045200.75718949
88Renin secretion_Homo sapiens_hsa049240.75462308
89Small cell lung cancer_Homo sapiens_hsa052220.75171247
90Choline metabolism in cancer_Homo sapiens_hsa052310.74579110
91Bladder cancer_Homo sapiens_hsa052190.74534720
92cAMP signaling pathway_Homo sapiens_hsa040240.74512377
93Type I diabetes mellitus_Homo sapiens_hsa049400.74166634
94Glutamatergic synapse_Homo sapiens_hsa047240.72551868
95Pancreatic cancer_Homo sapiens_hsa052120.71374242
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70638254
97Ras signaling pathway_Homo sapiens_hsa040140.68598667
98p53 signaling pathway_Homo sapiens_hsa041150.67695381
99Circadian entrainment_Homo sapiens_hsa047130.67676989
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.67243428
101Gap junction_Homo sapiens_hsa045400.66084187
102Amoebiasis_Homo sapiens_hsa051460.66058479
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65965088
104Bile secretion_Homo sapiens_hsa049760.65907535
105Base excision repair_Homo sapiens_hsa034100.65856805
106Colorectal cancer_Homo sapiens_hsa052100.65154091
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63102315
108N-Glycan biosynthesis_Homo sapiens_hsa005100.62785527
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.62767202
110ErbB signaling pathway_Homo sapiens_hsa040120.62761143
111Endometrial cancer_Homo sapiens_hsa052130.62063180
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61182158
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60370107
114Non-small cell lung cancer_Homo sapiens_hsa052230.60049723
115Long-term potentiation_Homo sapiens_hsa047200.59983724
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59889878
117Glycerolipid metabolism_Homo sapiens_hsa005610.59421194
118HIF-1 signaling pathway_Homo sapiens_hsa040660.59210291
119Viral carcinogenesis_Homo sapiens_hsa052030.55595915
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55297406
121Vibrio cholerae infection_Homo sapiens_hsa051100.54184295
122Autoimmune thyroid disease_Homo sapiens_hsa053200.53393262
123MAPK signaling pathway_Homo sapiens_hsa040100.52754478
124Oxytocin signaling pathway_Homo sapiens_hsa049210.52479384
125Epstein-Barr virus infection_Homo sapiens_hsa051690.51169246
126Pathways in cancer_Homo sapiens_hsa052000.50569371
127Melanogenesis_Homo sapiens_hsa049160.50096640
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49628291
129Pentose phosphate pathway_Homo sapiens_hsa000300.48759180
130Dopaminergic synapse_Homo sapiens_hsa047280.48105752
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47515457
132Galactose metabolism_Homo sapiens_hsa000520.46472553
133VEGF signaling pathway_Homo sapiens_hsa043700.44524789
134T cell receptor signaling pathway_Homo sapiens_hsa046600.41925485
135HTLV-I infection_Homo sapiens_hsa051660.41592467
136Glioma_Homo sapiens_hsa052140.41324367
137Thyroid cancer_Homo sapiens_hsa052160.40922127
138Proteoglycans in cancer_Homo sapiens_hsa052050.37672519
139Homologous recombination_Homo sapiens_hsa034400.36753031
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35978362
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35463108
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35409610
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34382980
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28000441
145Focal adhesion_Homo sapiens_hsa045100.27177227
146Renin-angiotensin system_Homo sapiens_hsa046140.27018296
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.25747840
148Melanoma_Homo sapiens_hsa052180.25270437
149MicroRNAs in cancer_Homo sapiens_hsa052060.25191584

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