CPNE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)5.76875238
2regulation of memory T cell differentiation (GO:0043380)4.92218794
3lipid particle organization (GO:0034389)4.76792754
4regulation of establishment of cell polarity (GO:2000114)4.65978409
5COPII vesicle coating (GO:0048208)4.54925374
6negative regulation of multicellular organism growth (GO:0040015)4.45477163
7lactate metabolic process (GO:0006089)4.18866597
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15930273
9keratinocyte development (GO:0003334)4.09640369
10peripheral nervous system neuron development (GO:0048935)3.98672823
11intestinal epithelial cell development (GO:0060576)3.96457785
12branched-chain amino acid catabolic process (GO:0009083)3.83410072
13sex differentiation (GO:0007548)3.83296460
14cellular ketone body metabolic process (GO:0046950)3.80468451
15iron ion import (GO:0097286)3.73182956
16regulation of establishment or maintenance of cell polarity (GO:0032878)3.71864307
17neutrophil activation involved in immune response (GO:0002283)3.59761527
18ER overload response (GO:0006983)3.52845700
19thrombin receptor signaling pathway (GO:0070493)3.49435625
20ketone body metabolic process (GO:1902224)3.49426446
21regulation of metalloenzyme activity (GO:0048552)3.48123361
22biotin metabolic process (GO:0006768)3.42162858
23nucleoside diphosphate catabolic process (GO:0009134)3.38081419
24regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.34461274
25protein autoprocessing (GO:0016540)3.34209746
26bile acid biosynthetic process (GO:0006699)3.30149354
27glucuronate metabolic process (GO:0019585)3.25040542
28uronic acid metabolic process (GO:0006063)3.25040542
29positive regulation of interferon-alpha production (GO:0032727)3.23819607
30regulation of interleukin-13 production (GO:0032656)3.23742908
31cellular glucuronidation (GO:0052695)3.19251324
32stress granule assembly (GO:0034063)3.17951497
33definitive hemopoiesis (GO:0060216)3.17185703
34COPI coating of Golgi vesicle (GO:0048205)3.13596211
35Golgi transport vesicle coating (GO:0048200)3.13596211
36ADP metabolic process (GO:0046031)3.13535069
37neutrophil activation (GO:0042119)3.12229627
38L-phenylalanine metabolic process (GO:0006558)3.11279009
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.11279009
40regulation of interferon-beta biosynthetic process (GO:0045357)3.10160943
41water-soluble vitamin biosynthetic process (GO:0042364)3.04027741
42regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.04016474
43gland morphogenesis (GO:0022612)3.04012574
44granulocyte activation (GO:0036230)3.02124376
45regulation of interferon-alpha production (GO:0032647)3.01934102
46negative regulation of receptor-mediated endocytosis (GO:0048261)3.01751427
47auditory receptor cell differentiation (GO:0042491)3.01568126
48ER to Golgi vesicle-mediated transport (GO:0006888)2.99992111
49Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96134736
50positive regulation of actin filament depolymerization (GO:0030836)2.95846625
51CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.94885699
52response to X-ray (GO:0010165)2.91006786
53negative regulation of homotypic cell-cell adhesion (GO:0034111)2.88988026
54positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.88836776
55UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87820725
56regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.84846162
57negative regulation of execution phase of apoptosis (GO:1900118)2.82683425
58response to type I interferon (GO:0034340)2.82397882
59regulation of protein heterodimerization activity (GO:0043497)2.81354829
60type I interferon signaling pathway (GO:0060337)2.81153054
61cellular response to type I interferon (GO:0071357)2.81153054
62pteridine-containing compound biosynthetic process (GO:0042559)2.80416431
63retinol metabolic process (GO:0042572)2.78938560
64negative regulation of keratinocyte proliferation (GO:0010839)2.77878133
65positive regulation of protein autophosphorylation (GO:0031954)2.77585695
66sequestering of extracellular ligand from receptor (GO:0035581)2.77197058
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.75812426
68zinc ion transport (GO:0006829)2.75464854
69polyol catabolic process (GO:0046174)2.75332681
70magnesium ion transport (GO:0015693)2.73956162
71regulation of keratinocyte proliferation (GO:0010837)2.73185999
72production of molecular mediator involved in inflammatory response (GO:0002532)2.72197981
73alternative mRNA splicing, via spliceosome (GO:0000380)2.71749421
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69673200
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69673200
76zinc ion transmembrane transport (GO:0071577)2.67542148
77response to interferon-alpha (GO:0035455)2.66922847
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65750877
79L-phenylalanine catabolic process (GO:0006559)2.65750877
80L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65322812
81negative regulation of endothelial cell apoptotic process (GO:2000352)2.64222168
82amino-acid betaine transport (GO:0015838)2.63011613
83carnitine transport (GO:0015879)2.63011613
84regulation of interleukin-5 production (GO:0032674)2.62906355
85early endosome to late endosome transport (GO:0045022)2.62069054
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.61009763
87regulation of protein glycosylation (GO:0060049)2.60170390
88branched-chain amino acid metabolic process (GO:0009081)2.60098172
89negative regulation of myeloid cell apoptotic process (GO:0033033)2.59950916
90phospholipid efflux (GO:0033700)2.59841527
91cellular response to exogenous dsRNA (GO:0071360)2.59834717
92negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.59760653
93Golgi to endosome transport (GO:0006895)2.58823721
94regulation of natural killer cell differentiation (GO:0032823)2.58488732
95response to peptidoglycan (GO:0032494)2.57568984
96low-density lipoprotein particle remodeling (GO:0034374)2.56724083
97somite rostral/caudal axis specification (GO:0032525)2.56197110
98regulation of integrin-mediated signaling pathway (GO:2001044)2.56090625
99L-methionine salvage (GO:0071267)2.55243170
100L-methionine biosynthetic process (GO:0071265)2.55243170
101amino acid salvage (GO:0043102)2.55243170
102negative regulation of phagocytosis (GO:0050765)2.55223121
103positive regulation of natural killer cell differentiation (GO:0032825)2.54125380
104acrosome assembly (GO:0001675)2.53403090
105inositol phosphate catabolic process (GO:0071545)2.52830515
106negative regulation of coagulation (GO:0050819)2.51993237
107regulation of sulfur metabolic process (GO:0042762)2.50972552
108estrogen biosynthetic process (GO:0006703)2.50651613
109regulation of acyl-CoA biosynthetic process (GO:0050812)2.50490960
110glandular epithelial cell differentiation (GO:0002067)2.49961725
111response to lipoprotein particle (GO:0055094)2.47688955
112carnitine shuttle (GO:0006853)2.47377897
113respiratory burst (GO:0045730)2.47080374
114signal peptide processing (GO:0006465)2.46875617
115positive regulation of cellular amide metabolic process (GO:0034250)2.46409252
116fatty acid transmembrane transport (GO:1902001)2.45794247
117peroxisome fission (GO:0016559)2.45522301
118import into cell (GO:0098657)2.45519060
119epithelial cell maturation (GO:0002070)2.45396120
120phospholipid scrambling (GO:0017121)2.43381740
121actin nucleation (GO:0045010)2.43319579
122antigen processing and presentation of endogenous antigen (GO:0019883)2.43051330
123cell adhesion mediated by integrin (GO:0033627)2.42428944
124negative regulation of lipid storage (GO:0010888)2.42001895
125dicarboxylic acid biosynthetic process (GO:0043650)2.41293613
126nucleotide transmembrane transport (GO:1901679)2.38545383
127negative regulation of calcium ion transport into cytosol (GO:0010523)2.37743886
128membrane budding (GO:0006900)2.37705855
129desmosome organization (GO:0002934)2.37312430
130sterol catabolic process (GO:0016127)2.36379617
131cholesterol catabolic process (GO:0006707)2.36379617
132sequestering of metal ion (GO:0051238)2.36087843
133fibroblast migration (GO:0010761)2.36003838
134regulation of interleukin-8 secretion (GO:2000482)2.35838157
135embryonic process involved in female pregnancy (GO:0060136)2.35704601
136Leydig cell differentiation (GO:0033327)2.35679605
137polarized epithelial cell differentiation (GO:0030859)2.35643436
138regulation of protein activation cascade (GO:2000257)2.35478488
139negative regulation of type 2 immune response (GO:0002829)2.35434520
140intra-Golgi vesicle-mediated transport (GO:0006891)2.34923051
141positive regulation of macroautophagy (GO:0016239)2.34601923
142myoblast migration (GO:0051451)2.34122164
143cytokine secretion (GO:0050663)2.33978917
144regulation of complement activation (GO:0030449)2.33944677
145hepatocyte apoptotic process (GO:0097284)2.33829012
146ribosome assembly (GO:0042255)2.33795651
147beta-amyloid metabolic process (GO:0050435)2.32528368
148kynurenine metabolic process (GO:0070189)2.32057834
149righting reflex (GO:0060013)2.31999692
150sequestering of actin monomers (GO:0042989)2.31927060
151peptidyl-glutamic acid carboxylation (GO:0017187)2.31779794
152protein carboxylation (GO:0018214)2.31779794
153embryonic foregut morphogenesis (GO:0048617)2.31583436
154positive regulation of alpha-beta T cell proliferation (GO:0046641)2.31232034
155bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31007833
156regulation of cofactor metabolic process (GO:0051193)2.30078907
157regulation of coenzyme metabolic process (GO:0051196)2.30078907
158killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.28694645
159disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.28694645
160aromatic amino acid family catabolic process (GO:0009074)2.28627652
161hydrogen peroxide biosynthetic process (GO:0050665)2.28501186
162cellular response to interferon-alpha (GO:0035457)2.27446818
163negative regulation of complement activation (GO:0045916)2.27025742
164negative regulation of protein activation cascade (GO:2000258)2.26969030
165positive regulation of interferon-beta production (GO:0032728)2.26714455
166interferon-gamma-mediated signaling pathway (GO:0060333)2.25974729
167negative regulation of hemostasis (GO:1900047)2.25625827
168negative regulation of blood coagulation (GO:0030195)2.25625827
169negative regulation of platelet activation (GO:0010544)2.25037219
170hemidesmosome assembly (GO:0031581)2.24592272
171urate metabolic process (GO:0046415)2.24289685
172complement activation, alternative pathway (GO:0006957)2.24083081
173negative regulation of protein autophosphorylation (GO:0031953)2.22652186
174sulfur amino acid catabolic process (GO:0000098)2.21203081
175phospholipid homeostasis (GO:0055091)2.20935690
176dendritic cell chemotaxis (GO:0002407)2.19714392
177regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.19107533
178regulation of monocyte chemotaxis (GO:0090025)2.18331754
179regulation of T cell chemotaxis (GO:0010819)2.17602616
180positive regulation of T cell chemotaxis (GO:0010820)2.17602616
181mitochondrial calcium ion transport (GO:0006851)2.17597881
182immunoglobulin mediated immune response (GO:0016064)2.16535555
183positive regulation of smooth muscle cell migration (GO:0014911)2.16391987
184negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.16269051
185leukocyte aggregation (GO:0070486)2.15816770
186growth hormone receptor signaling pathway (GO:0060396)2.15381117
187regulation of heterotypic cell-cell adhesion (GO:0034114)2.15044912
188reactive oxygen species biosynthetic process (GO:1903409)2.14614700
189alpha-linolenic acid metabolic process (GO:0036109)2.13571115
190valine metabolic process (GO:0006573)2.13474382
191regulation of coagulation (GO:0050818)2.13169621
192reverse cholesterol transport (GO:0043691)2.11906877
193response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.11670482
194response to host immune response (GO:0052572)2.11670482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.65638804
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.43372662
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.03262163
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.67391236
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.21623878
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.07091213
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87079731
8GATA1_22025678_ChIP-Seq_K562_Human2.71608515
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71380889
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.68110817
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50855365
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.49808925
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.46660989
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44032906
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.38033134
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.36206084
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35455604
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.31897885
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30830652
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.29260734
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.29202542
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28633316
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25255427
24AR_21909140_ChIP-Seq_LNCAP_Human2.23994943
25CLOCK_20551151_ChIP-Seq_293T_Human2.23827657
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23263481
27IGF1R_20145208_ChIP-Seq_DFB_Human2.19969308
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19822480
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19160326
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.18151017
31* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.16141502
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16021308
33PIAS1_25552417_ChIP-Seq_VCAP_Human2.14572841
34ZNF263_19887448_ChIP-Seq_K562_Human2.10669234
35ER_23166858_ChIP-Seq_MCF-7_Human2.08698572
36FUS_26573619_Chip-Seq_HEK293_Human2.07073040
37ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04280005
38PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03915725
39* LXR_22158963_ChIP-Seq_LIVER_Mouse1.99159732
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98386568
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97435989
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93965825
43* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.86676517
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85767618
45SOX2_20726797_ChIP-Seq_SW620_Human1.84876226
46E2F7_22180533_ChIP-Seq_HELA_Human1.80503918
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80313037
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79846980
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79846980
50VDR_22108803_ChIP-Seq_LS180_Human1.76230896
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72579103
52CJUN_26792858_Chip-Seq_BT549_Human1.72447102
53* TAF15_26573619_Chip-Seq_HEK293_Human1.69778721
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68388178
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66657012
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66424814
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65215364
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.63887155
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.62836119
60GBX2_23144817_ChIP-Seq_PC3_Human1.60970623
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.59300076
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57973482
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57535602
64EWS_26573619_Chip-Seq_HEK293_Human1.55858989
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55079143
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55051556
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54431365
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53515392
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53515392
70AHR_22903824_ChIP-Seq_MCF-7_Human1.52744535
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51984862
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.51325577
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51144138
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.50540809
75CDX2_22108803_ChIP-Seq_LS180_Human1.49746871
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48687539
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48059965
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47663534
79* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43706019
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.42329941
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.42024114
82RUNX_20019798_ChIP-Seq_JUKART_Human1.40384077
83BCAT_22108803_ChIP-Seq_LS180_Human1.38768203
84SMAD4_21799915_ChIP-Seq_A2780_Human1.38687955
85FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.38201024
86VDR_24787735_ChIP-Seq_THP-1_Human1.37652810
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36297787
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.35606281
89P300_19829295_ChIP-Seq_ESCs_Human1.32681938
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32665396
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31874820
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.31859239
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31429819
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.31068859
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29957151
96PU_27001747_Chip-Seq_BMDM_Mouse1.29869696
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29729308
98* FOXA1_25552417_ChIP-Seq_VCAP_Human1.29258553
99MYB_26560356_Chip-Seq_TH2_Human1.29063082
100HTT_18923047_ChIP-ChIP_STHdh_Human1.28852725
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28035877
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.26320268
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24471210
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24273344
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24009188
106TP53_18474530_ChIP-ChIP_U2OS_Human1.23946049
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.23548551
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23161078
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21879941
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20235422
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.18951625
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.18464246
113GATA4_25053715_ChIP-Seq_YYC3_Human1.18455856
114SOX2_18555785_Chip-Seq_ESCs_Mouse1.17605937
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17137964
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16268387
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.15955981
118AR_25329375_ChIP-Seq_VCAP_Human1.15693521
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15550663
120CDX2_20551321_ChIP-Seq_CACO-2_Human1.13888172
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13026946
122P53_22387025_ChIP-Seq_ESCs_Mouse1.13024001
123ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12823808
124STAT3_23295773_ChIP-Seq_U87_Human1.12456151
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.12353575
126NFE2_27457419_Chip-Seq_LIVER_Mouse1.11988509
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.11202735
128* E2F1_18555785_Chip-Seq_ESCs_Mouse1.11068903
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10623000
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10030348
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09712140
132SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09313614
133P300_18555785_Chip-Seq_ESCs_Mouse1.08656284
134TCF4_22108803_ChIP-Seq_LS180_Human1.07951792
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05739028
136BRD4_25478319_ChIP-Seq_HGPS_Human1.04969289
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03504176
138ZNF274_21170338_ChIP-Seq_K562_Hela1.03323649
139ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02245180
140SPI1_23547873_ChIP-Seq_NB4_Human1.01612356
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01484294
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01427987
143CHD1_26751641_Chip-Seq_LNCaP_Human1.01073070
144MYB_26560356_Chip-Seq_TH1_Human1.01042525
145ELF5_23300383_ChIP-Seq_T47D_Human1.00928525
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.00249133
147VDR_24763502_ChIP-Seq_THP-1_Human1.00120775
148ELK1_19687146_ChIP-ChIP_HELA_Human0.99218848
149FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99145008
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.98762227
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.97622252
152SALL1_21062744_ChIP-ChIP_HESCs_Human0.97438454
153SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96510724
154ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96475056
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96444376
156SCL_19346495_ChIP-Seq_HPC-7_Human0.96261236
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94673259
158TP63_23658742_ChIP-Seq_EP156T_Human0.93226959
159PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90200015
160CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89405349
161TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89327987
162ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89133951
163JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88948210
164HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87647317
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85930334
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84671959
167* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83399724
168* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81484038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.88571674
2MP0003011_delayed_dark_adaptation3.10224399
3MP0001986_abnormal_taste_sensitivity2.75098537
4MP0002837_dystrophic_cardiac_calcinosis2.68956714
5MP0003436_decreased_susceptibility_to2.42534654
6MP0010352_gastrointestinal_tract_polyps2.37237471
7MP0002909_abnormal_adrenal_gland2.27880836
8MP0003724_increased_susceptibility_to2.26833479
9MP0002166_altered_tumor_susceptibility2.22554037
10MP0006072_abnormal_retinal_apoptosis2.21167166
11MP0005408_hypopigmentation2.17354971
12MP0002009_preneoplasia2.13758843
13MP0001835_abnormal_antigen_presentation2.07753997
14MP0000372_irregular_coat_pigmentation2.06643183
15MP0000013_abnormal_adipose_tissue1.98490228
16MP0005379_endocrine/exocrine_gland_phen1.98438115
17MP0002006_tumorigenesis1.93813641
18MP0005085_abnormal_gallbladder_physiolo1.89217761
19MP0002139_abnormal_hepatobiliary_system1.87624787
20MP0005075_abnormal_melanosome_morpholog1.86020386
21MP0005248_abnormal_Harderian_gland1.84735867
22MP0002148_abnormal_hypersensitivity_rea1.83100092
23MP0008438_abnormal_cutaneous_collagen1.78709914
24MP0001944_abnormal_pancreas_morphology1.77332876
25MP0003191_abnormal_cellular_cholesterol1.76525790
26MP0009785_altered_susceptibility_to1.74259557
27MP0002877_abnormal_melanocyte_morpholog1.72741150
28MP0005464_abnormal_platelet_physiology1.69300812
29MP0003300_gastrointestinal_ulcer1.69277356
30MP0005360_urolithiasis1.68080767
31MP0005275_abnormal_skin_tensile1.65645921
32MP0004381_abnormal_hair_follicle1.62887397
33MP0003566_abnormal_cell_adhesion1.59990356
34MP0003705_abnormal_hypodermis_morpholog1.59822183
35MP0010234_abnormal_vibrissa_follicle1.57129780
36MP0009697_abnormal_copulation1.56186825
37MP0005365_abnormal_bile_salt1.51216954
38MP0003868_abnormal_feces_composition1.51193973
39MP0002419_abnormal_innate_immunity1.50581481
40MP0000569_abnormal_digit_pigmentation1.49546563
41MP0001533_abnormal_skeleton_physiology1.48415010
42MP0003279_aneurysm1.48297702
43MP0005253_abnormal_eye_physiology1.46321486
44MP0003806_abnormal_nucleotide_metabolis1.45982474
45MP0002060_abnormal_skin_morphology1.44917149
46MP0004947_skin_inflammation1.42459893
47MP0000377_abnormal_hair_follicle1.41571590
48MP0009764_decreased_sensitivity_to1.41462909
49MP0002876_abnormal_thyroid_physiology1.41213461
50MP0008875_abnormal_xenobiotic_pharmacok1.40254711
51MP0002396_abnormal_hematopoietic_system1.39494887
52MP0001853_heart_inflammation1.39297026
53MP0002163_abnormal_gland_morphology1.37548854
54MP0005000_abnormal_immune_tolerance1.37150247
55MP0004782_abnormal_surfactant_physiolog1.35702675
56MP0005025_abnormal_response_to1.34735346
57MP0006054_spinal_hemorrhage1.33240260
58MP0005220_abnormal_exocrine_pancreas1.30129812
59MP0008057_abnormal_DNA_replication1.29869483
60MP0003186_abnormal_redox_activity1.29864287
61MP0001756_abnormal_urination1.29514489
62MP0005397_hematopoietic_system_phenotyp1.26929538
63MP0001545_abnormal_hematopoietic_system1.26929538
64MP0003950_abnormal_plasma_membrane1.26633701
65MP0002234_abnormal_pharynx_morphology1.25930863
66MP0005023_abnormal_wound_healing1.25804957
67MP0005187_abnormal_penis_morphology1.25615659
68MP0000647_abnormal_sebaceous_gland1.25473655
69MP0000371_diluted_coat_color1.23314335
70MP0002254_reproductive_system_inflammat1.23246615
71MP0003941_abnormal_skin_development1.22766792
72MP0005332_abnormal_amino_acid1.18243935
73MP0003252_abnormal_bile_duct1.18024620
74MP0002693_abnormal_pancreas_physiology1.17513870
75MP0005636_abnormal_mineral_homeostasis1.17198299
76MP0005451_abnormal_body_composition1.15617146
77MP0000858_altered_metastatic_potential1.14258474
78MP0003123_paternal_imprinting1.13864782
79MP0000627_abnormal_mammary_gland1.13671292
80MP0005083_abnormal_biliary_tract1.11802321
81MP0000613_abnormal_salivary_gland1.11718697
82MP0002405_respiratory_system_inflammati1.11371234
83MP0001845_abnormal_inflammatory_respons1.10790516
84MP0010386_abnormal_urinary_bladder1.10299207
85MP0000427_abnormal_hair_cycle1.09703500
86MP0002452_abnormal_antigen_presenting1.08982485
87MP0001800_abnormal_humoral_immune1.08249837
88MP0003890_abnormal_embryonic-extraembry1.07592635
89MP0003183_abnormal_peptide_metabolism1.05820482
90MP0003453_abnormal_keratinocyte_physiol1.05236135
91MP0002090_abnormal_vision1.05123219
92MP0001186_pigmentation_phenotype1.03896710
93MP0000465_gastrointestinal_hemorrhage1.03394993
94MP0010368_abnormal_lymphatic_system1.02491595
95MP0010155_abnormal_intestine_physiology1.02134178
96MP0000343_altered_response_to1.02059877
97MP0002938_white_spotting1.02015838
98MP0001958_emphysema1.01685247
99MP0005387_immune_system_phenotype1.00874481
100MP0001790_abnormal_immune_system1.00874481
101MP0005646_abnormal_pituitary_gland1.00853039
102MP0003718_maternal_effect0.98718112
103MP0002796_impaired_skin_barrier0.97799735
104MP0001216_abnormal_epidermal_layer0.96311456
105MP0004233_abnormal_muscle_weight0.95892539
106MP0003936_abnormal_reproductive_system0.95328652
107MP0004272_abnormal_basement_membrane0.95064967
108MP0004808_abnormal_hematopoietic_stem0.94935243
109MP0002723_abnormal_immune_serum0.94799995
110MP0005390_skeleton_phenotype0.94558771
111MP0000003_abnormal_adipose_tissue0.94233934
112MP0003943_abnormal_hepatobiliary_system0.94226774
113MP0008469_abnormal_protein_level0.93916912
114MP0004264_abnormal_extraembryonic_tissu0.93745046
115MP0002928_abnormal_bile_duct0.93057951
116MP0003195_calcinosis0.92918592
117MP0005257_abnormal_intraocular_pressure0.92553249
118MP0001243_abnormal_dermal_layer0.92129464
119MP0009278_abnormal_bone_marrow0.92079004
120MP0000538_abnormal_urinary_bladder0.91678385
121MP0004883_abnormal_blood_vessel0.91385478
122MP0002075_abnormal_coat/hair_pigmentati0.91065414
123MP0001819_abnormal_immune_cell0.90468298
124MP0005503_abnormal_tendon_morphology0.90322520
125MP0001881_abnormal_mammary_gland0.89619755
126MP0009053_abnormal_anal_canal0.89474946
127MP0000685_abnormal_immune_system0.89132827
128MP0001661_extended_life_span0.89104052
129MP0002420_abnormal_adaptive_immunity0.89096124
130MP0001879_abnormal_lymphatic_vessel0.88958734
131MP0010307_abnormal_tumor_latency0.88952320
132MP0001346_abnormal_lacrimal_gland0.86733662
133MP0010678_abnormal_skin_adnexa0.86711963
134MP0000383_abnormal_hair_follicle0.85213796
135MP0005164_abnormal_response_to0.84888443
136MP0010329_abnormal_lipoprotein_level0.84654448
137MP0002160_abnormal_reproductive_system0.84529678
138MP0002078_abnormal_glucose_homeostasis0.84122826
139MP0000516_abnormal_urinary_system0.84000108
140MP0005367_renal/urinary_system_phenotyp0.84000108
141MP0000358_abnormal_cell_content/0.83696564
142MP0004858_abnormal_nervous_system0.83195176
143MP0004019_abnormal_vitamin_homeostasis0.83050881
144MP0009379_abnormal_foot_pigmentation0.82951626
145MP0002896_abnormal_bone_mineralization0.82828836
146MP0000537_abnormal_urethra_morphology0.80056890
147MP0002138_abnormal_hepatobiliary_system0.79571212
148MP0002098_abnormal_vibrissa_morphology0.78933900
149MP0003763_abnormal_thymus_physiology0.78654218
150MP0000609_abnormal_liver_physiology0.78500509
151MP0001666_abnormal_nutrient_absorption0.78096128
152MP0004215_abnormal_myocardial_fiber0.75814096
153MP0005645_abnormal_hypothalamus_physiol0.74756130
154MP0005395_other_phenotype0.71882201
155MP0005647_abnormal_sex_gland0.69544821
156MP0003786_premature_aging0.68771382
157MP0002084_abnormal_developmental_patter0.68436327
158MP0000639_abnormal_adrenal_gland0.67338176
159MP0010771_integument_phenotype0.67090754
160MP0002118_abnormal_lipid_homeostasis0.66744450
161MP0005084_abnormal_gallbladder_morpholo0.65932974
162MP0002282_abnormal_trachea_morphology0.62999860
163MP0003937_abnormal_limbs/digits/tail_de0.62927559
164MP0000762_abnormal_tongue_morphology0.61187062
165MP0002177_abnormal_outer_ear0.60798951
166MP0006035_abnormal_mitochondrial_morpho0.60723540

Predicted human phenotypes

RankGene SetZ-score
1Dysmetric saccades (HP:0000641)4.26975035
2Eczematoid dermatitis (HP:0000976)4.24702779
3Autoimmune thrombocytopenia (HP:0001973)4.02125694
4Postural tremor (HP:0002174)3.65432574
5Action tremor (HP:0002345)3.64123478
6Prostate neoplasm (HP:0100787)3.55501812
7Recurrent gram-negative bacterial infections (HP:0005420)3.51251511
8Congenital malformation of the right heart (HP:0011723)3.40647517
9Double outlet right ventricle (HP:0001719)3.40647517
10Tetraparesis (HP:0002273)3.34324863
11Proximal tubulopathy (HP:0000114)3.32310877
12Systemic lupus erythematosus (HP:0002725)3.31323543
13Hypoglycemic seizures (HP:0002173)3.24404744
14Osteolytic defects of the phalanges of the hand (HP:0009771)3.23565663
15Osteolytic defects of the hand bones (HP:0009699)3.23565663
16Genetic anticipation (HP:0003743)3.09728807
17Hypothermia (HP:0002045)3.07429241
18Ketoacidosis (HP:0001993)2.99501359
19Recurrent abscess formation (HP:0002722)2.98442313
20Myocardial infarction (HP:0001658)2.97121434
21Myositis (HP:0100614)2.95833255
22Papillary thyroid carcinoma (HP:0002895)2.95185654
23Elevated erythrocyte sedimentation rate (HP:0003565)2.92479466
24Submucous cleft hard palate (HP:0000176)2.91273542
25Interstitial pulmonary disease (HP:0006530)2.84475954
26Recurrent bacterial skin infections (HP:0005406)2.83398736
27Pheochromocytoma (HP:0002666)2.76087080
28Abnormal hemoglobin (HP:0011902)2.75290693
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69056662
30Lip pit (HP:0100267)2.68994429
31Hyperinsulinemic hypoglycemia (HP:0000825)2.67077787
32Progressive cerebellar ataxia (HP:0002073)2.67077398
33Abnormality of the prostate (HP:0008775)2.65275683
34Periodontitis (HP:0000704)2.65242941
35Hyperglycemia (HP:0003074)2.64012982
36Gaze-evoked nystagmus (HP:0000640)2.63012150
37Hematochezia (HP:0002573)2.62761955
38Vertebral compression fractures (HP:0002953)2.62482284
39Thyroid carcinoma (HP:0002890)2.61398209
40Mediastinal lymphadenopathy (HP:0100721)2.59681815
41Testicular neoplasm (HP:0010788)2.58584659
42Microglossia (HP:0000171)2.54207274
43Abnormality of the common coagulation pathway (HP:0010990)2.51926591
44Syringomyelia (HP:0003396)2.51787597
45Spinal cord lesions (HP:0100561)2.51787597
46Nephritis (HP:0000123)2.51570536
47Thick nail (HP:0001805)2.50188639
48Abnormal biliary tract morphology (HP:0012440)2.47662645
49Intestinal atresia (HP:0011100)2.46548290
50Thoracolumbar scoliosis (HP:0002944)2.45385142
51Conjunctival hamartoma (HP:0100780)2.44359046
52Hamartoma of the eye (HP:0010568)2.43499594
53Complement deficiency (HP:0004431)2.43374077
54Biliary tract neoplasm (HP:0100574)2.43205665
55Asymmetry of the thorax (HP:0001555)2.42658869
56Alopecia of scalp (HP:0002293)2.40980931
57Neuroendocrine neoplasm (HP:0100634)2.36711325
58Intrahepatic cholestasis (HP:0001406)2.35930286
59Glomerulonephritis (HP:0000099)2.35921650
60Short nail (HP:0001799)2.34726294
61Macroorchidism (HP:0000053)2.34423290
62Abnormality of vitamin B metabolism (HP:0004340)2.34351972
63Breast carcinoma (HP:0003002)2.32958419
64Orchitis (HP:0100796)2.31191735
65Vasculitis (HP:0002633)2.30024894
66Popliteal pterygium (HP:0009756)2.29212663
67Abnormality of macular pigmentation (HP:0008002)2.28522834
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28462361
69Abnormality of complement system (HP:0005339)2.27841114
70Mitral stenosis (HP:0001718)2.27423338
71Abnormality of vitamin metabolism (HP:0100508)2.27301356
72Symptomatic seizures (HP:0011145)2.27109463
73Deep venous thrombosis (HP:0002625)2.25198844
74Unilateral renal agenesis (HP:0000122)2.25064386
75Xanthomatosis (HP:0000991)2.23705063
76Neoplasm of the adrenal gland (HP:0100631)2.21778735
77Adrenal hypoplasia (HP:0000835)2.21427082
78Abnormality of methionine metabolism (HP:0010901)2.17169674
79Cardiovascular calcification (HP:0011915)2.15044668
80Enlarged penis (HP:0000040)2.12704385
81Progressive hearing impairment (HP:0001730)2.12087915
82Hypobetalipoproteinemia (HP:0003563)2.11519943
83Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11185660
84Curly hair (HP:0002212)2.10768406
85Acute myeloid leukemia (HP:0004808)2.09728004
86Peritonitis (HP:0002586)2.07440903
87Methylmalonic acidemia (HP:0002912)2.07249079
88Increased mean platelet volume (HP:0011877)2.07178630
89Impaired vibratory sensation (HP:0002495)2.05773597
90Fat malabsorption (HP:0002630)2.05235086
91Joint hemorrhage (HP:0005261)2.05022702
92Abnormality of glycolysis (HP:0004366)2.04660476
93Hyperammonemia (HP:0001987)2.04604549
94Vascular calcification (HP:0004934)2.04525218
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.03310679
96Septate vagina (HP:0001153)2.01929881
97Pustule (HP:0200039)2.01666744
98Cutaneous melanoma (HP:0012056)2.01181644
99Abnormality of macrophages (HP:0004311)2.01044511
100Palmoplantar hyperkeratosis (HP:0000972)2.00917727
101Palmar hyperkeratosis (HP:0010765)1.98572908
102Abnormality of the distal phalanges of the toes (HP:0010182)1.97185722
103IgM deficiency (HP:0002850)1.96069924
104Epidermoid cyst (HP:0200040)1.95981158
105Arterial thrombosis (HP:0004420)1.95189777
106Gingival bleeding (HP:0000225)1.95163894
107Aortic aneurysm (HP:0004942)1.94749003
108Vacuolated lymphocytes (HP:0001922)1.94653550
109Autoimmune hemolytic anemia (HP:0001890)1.93173567
110Abnormal platelet volume (HP:0011876)1.92995611
111Postnatal microcephaly (HP:0005484)1.92994289
112Right ventricular cardiomyopathy (HP:0011663)1.92463845
113Gingivitis (HP:0000230)1.92122237
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92067696
115Osteomyelitis (HP:0002754)1.91305597
116Growth hormone excess (HP:0000845)1.90138702
117Prolonged partial thromboplastin time (HP:0003645)1.89241409
118Hypoglycemic coma (HP:0001325)1.88746357
119Rhabdomyosarcoma (HP:0002859)1.87724492
120Esophageal varix (HP:0002040)1.87422945
121Camptodactyly of toe (HP:0001836)1.87220052
122Plantar hyperkeratosis (HP:0007556)1.87143971
123Disproportionate short-trunk short stature (HP:0003521)1.87142253
124Conjugated hyperbilirubinemia (HP:0002908)1.86271630
125Limb ataxia (HP:0002070)1.85059113
126Dysdiadochokinesis (HP:0002075)1.84897315
127Abnormality of the lumbar spine (HP:0100712)1.83095295
128Abnormality of the nasal septum (HP:0000419)1.82849901
129Hydroxyprolinuria (HP:0003080)1.82754772
130Abnormality of proline metabolism (HP:0010907)1.82754772
131Nausea (HP:0002018)1.82504600
132Neoplasm of the adrenal cortex (HP:0100641)1.82360289
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81917900
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.80683575
135Hypoplasia of the fovea (HP:0007750)1.80683575
136Axonal loss (HP:0003447)1.80257833
137Abnormality of the intrinsic pathway (HP:0010989)1.79601436
138Abnormality of fatty-acid metabolism (HP:0004359)1.79028600
139Spontaneous hematomas (HP:0007420)1.78640089
140Increased CSF protein (HP:0002922)1.75772289
141Broad face (HP:0000283)1.75303758
142Abnormality of the astrocytes (HP:0100707)1.75217614
143Astrocytoma (HP:0009592)1.75217614
144Abnormality of the pleura (HP:0002103)1.73810902
145Advanced eruption of teeth (HP:0006288)1.72060064
146Palpitations (HP:0001962)1.71763077
147Glioma (HP:0009733)1.71457303
148Abnormality of the hepatic vasculature (HP:0006707)1.71410388
149Concave nail (HP:0001598)1.71128597
150Fair hair (HP:0002286)1.70739465
151Onycholysis (HP:0001806)1.70397355
152Hypokinesia (HP:0002375)1.70334729
153Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69870054
154Orthostatic hypotension (HP:0001278)1.69566394
155Chronic obstructive pulmonary disease (HP:0006510)1.68234770
156Obstructive lung disease (HP:0006536)1.68234770
157Sparse lateral eyebrow (HP:0005338)1.66276701
158Abnormality of pyrimidine metabolism (HP:0004353)1.66055796
159Renal cortical cysts (HP:0000803)1.65943779
160Optic neuritis (HP:0100653)1.65560794
161Retrobulbar optic neuritis (HP:0100654)1.65560794
162Steatorrhea (HP:0002570)1.65435932
163Furrowed tongue (HP:0000221)1.65124744
164Protrusio acetabuli (HP:0003179)1.64641317
165Testicular atrophy (HP:0000029)1.64368649
166Bone cyst (HP:0012062)1.64082546
167Abnormality of the peritoneum (HP:0002585)1.64081062
168Neoplasm of the thyroid gland (HP:0100031)1.63780901
169Glomerulopathy (HP:0100820)1.63559651
170Neoplasm of the peripheral nervous system (HP:0100007)1.63372505
171Neonatal respiratory distress (HP:0002643)1.62555470
172Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62489881
173Ependymoma (HP:0002888)1.61632520
174IgA deficiency (HP:0002720)1.60636491
175Pendular nystagmus (HP:0012043)1.60557528
176Horizontal nystagmus (HP:0000666)1.60535877
177Micronodular cirrhosis (HP:0001413)1.60192818
178Azoospermia (HP:0000027)1.59772324
179Pancreatitis (HP:0001733)1.58613164
180Insidious onset (HP:0003587)1.58337782
181Termporal pattern (HP:0011008)1.58337782
182Urinary glycosaminoglycan excretion (HP:0003541)1.57848096
183Mucopolysacchariduria (HP:0008155)1.57848096
184Congenital cataract (HP:0000519)1.56677497
185Loss of speech (HP:0002371)1.55773538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.33877437
2FRK3.31382369
3SCYL23.31290751
4MAP3K143.18792824
5EIF2AK13.13106504
6NEK93.01846774
7OXSR12.35039748
8FGFR32.34839355
9MAP4K22.30074769
10MAP2K32.23752712
11TRPM72.22899431
12CLK12.19458206
13SIK32.16533602
14CDK192.15126065
15EPHA31.97630317
16ERBB31.96761608
17PRKD31.95838603
18MST41.89358848
19TRIM281.88614685
20BMPR1B1.77220918
21PIM21.72290822
22MAP3K21.70195188
23TBK11.69097408
24MST1R1.65360500
25IRAK41.63331317
26STK38L1.63282395
27PKN21.59346169
28NEK11.58958097
29EPHA21.56343508
30STK391.53662895
31MAP3K31.52846786
32ERN11.52517187
33GRK11.50533611
34TYK21.46083298
35STK31.43772656
36FGFR41.41326195
37JAK31.35488818
38ZAK1.34147102
39CDK61.33195208
40PAK31.31179207
41FLT31.30767256
42NME21.29706853
43ZAP701.29244227
44YES11.28924091
45IRAK31.28540734
46TAF11.25988076
47STK241.25727458
48TEC1.24532550
49TSSK61.19820041
50EPHB11.19336476
51IRAK11.18775181
52STK101.17083189
53LRRK21.14877038
54JAK11.13312159
55TGFBR11.12330795
56TGFBR21.11615369
57RIPK11.10820955
58IKBKE1.09856086
59CHUK1.06776951
60WNK31.05919007
61BMPR21.05220717
62IKBKB1.00316504
63PRKCE0.98712844
64BLK0.96876123
65FER0.96710287
66RIPK40.96561201
67PTK60.95749607
68NUAK10.95522851
69MAP3K120.94794213
70TNK20.94418591
71PIM10.93750968
72PAK40.92006816
73TESK10.91494920
74CSNK1G10.91269898
75MYLK0.88801535
76MARK30.88322492
77CSK0.86497983
78SIK10.86225379
79PHKG20.85419532
80PHKG10.85419532
81BRSK20.83061811
82PIK3CG0.79619246
83SGK20.79320480
84CSNK1G30.78167820
85PLK30.78157089
86CASK0.77993858
87EIF2AK20.77138863
88CSNK1A1L0.76690064
89WNK40.76140236
90RPS6KA20.75911555
91MAP2K20.74880622
92BTK0.74465204
93CSF1R0.72951673
94TTK0.72804435
95EEF2K0.72718629
96KIT0.72657302
97NLK0.72073700
98EPHB20.71337343
99MKNK10.69718758
100PASK0.67733214
101NEK60.67243056
102FGFR10.66505917
103PTK20.65904240
104MAP2K60.65703167
105MAPKAPK30.65438888
106HIPK20.64949686
107RPS6KA60.64319649
108MAPK40.64249215
109RPS6KB20.64006061
110STK40.63790213
111ERBB40.63411283
112BCR0.63255070
113RPS6KC10.62914424
114RPS6KL10.62914424
115BRD40.62396473
116PLK20.62142854
117LIMK10.62088285
118TAOK30.61436390
119MATK0.60881332
120PBK0.60436308
121LMTK20.59899926
122ITK0.59549839
123WEE10.58788043
124MKNK20.58166681
125INSRR0.58029658
126LCK0.57398803
127PIK3CA0.55694563
128CSNK1G20.55167779
129RET0.55077727
130MET0.54947229
131FGFR20.54817471
132MAP3K60.53934333
133ACVR1B0.53844551
134MAPKAPK20.53260113
135ILK0.52681135
136PINK10.52582270
137SGK30.51270232
138PRKAA20.51214568
139AKT30.50467713
140JAK20.50194688
141RPS6KB10.49423980
142LATS10.49048062
143MAP2K10.48627238
144PRKG20.48520778
145IGF1R0.48435303
146CAMK2D0.46334241
147AKT20.45925413
148BUB10.39460519
149ALK0.37741423
150RPS6KA40.36934426
151PRKD20.35292963
152ROCK20.33081525
153GSK3A0.31703011
154PRKCI0.30836177
155MUSK0.30142468
156STK380.29161451
157ATM0.27910619
158TNIK0.24251980
159SRPK10.21124561

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.40748218
2Protein export_Homo sapiens_hsa030603.36736305
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07441972
4Propanoate metabolism_Homo sapiens_hsa006403.01319693
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81210197
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70681303
7Staphylococcus aureus infection_Homo sapiens_hsa051502.61223790
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.55655865
9Butanoate metabolism_Homo sapiens_hsa006502.42407773
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.37253618
11Caffeine metabolism_Homo sapiens_hsa002322.26011503
12Complement and coagulation cascades_Homo sapiens_hsa046102.25986597
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12282562
14Leishmaniasis_Homo sapiens_hsa051402.07941605
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88849939
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85462500
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82134166
18Chemical carcinogenesis_Homo sapiens_hsa052041.79938037
19Fatty acid elongation_Homo sapiens_hsa000621.70364101
20Sulfur metabolism_Homo sapiens_hsa009201.67732183
21Circadian rhythm_Homo sapiens_hsa047101.66189895
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63248249
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63015662
24Starch and sucrose metabolism_Homo sapiens_hsa005001.60929780
25Non-homologous end-joining_Homo sapiens_hsa034501.60719406
26Steroid biosynthesis_Homo sapiens_hsa001001.54062413
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49565429
28Peroxisome_Homo sapiens_hsa041461.47606541
29Fatty acid degradation_Homo sapiens_hsa000711.42448690
30Pertussis_Homo sapiens_hsa051331.41096115
31Sphingolipid metabolism_Homo sapiens_hsa006001.38553305
32Histidine metabolism_Homo sapiens_hsa003401.35279325
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.34988646
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33711462
35Pyruvate metabolism_Homo sapiens_hsa006201.33378593
36Toxoplasmosis_Homo sapiens_hsa051451.32556339
37Graft-versus-host disease_Homo sapiens_hsa053321.30407983
38Retinol metabolism_Homo sapiens_hsa008301.29376225
39Legionellosis_Homo sapiens_hsa051341.27539861
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26955920
41Adherens junction_Homo sapiens_hsa045201.24708770
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.24408354
43Selenocompound metabolism_Homo sapiens_hsa004501.22913668
44Measles_Homo sapiens_hsa051621.20475365
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19272967
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18091062
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.17095059
48Fatty acid biosynthesis_Homo sapiens_hsa000611.16318849
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15254729
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.13086229
51Influenza A_Homo sapiens_hsa051641.13035676
52Tryptophan metabolism_Homo sapiens_hsa003801.11478779
53Hematopoietic cell lineage_Homo sapiens_hsa046401.10417647
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08043682
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07764188
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.07272013
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.05402122
58Hepatitis C_Homo sapiens_hsa051601.04548843
59N-Glycan biosynthesis_Homo sapiens_hsa005101.04050559
60PPAR signaling pathway_Homo sapiens_hsa033201.03224266
61NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03194129
62Malaria_Homo sapiens_hsa051441.02760414
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02295401
64Hepatitis B_Homo sapiens_hsa051611.00434619
65Osteoclast differentiation_Homo sapiens_hsa043800.95357001
66TNF signaling pathway_Homo sapiens_hsa046680.94976332
67Tuberculosis_Homo sapiens_hsa051520.93596591
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92910064
69Basal transcription factors_Homo sapiens_hsa030220.92021401
70Phagosome_Homo sapiens_hsa041450.91173749
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88036917
72ABC transporters_Homo sapiens_hsa020100.87572601
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86827398
74Salmonella infection_Homo sapiens_hsa051320.86778939
75Viral myocarditis_Homo sapiens_hsa054160.86272644
76Thyroid cancer_Homo sapiens_hsa052160.85081553
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84851399
78RNA degradation_Homo sapiens_hsa030180.84849385
79Phenylalanine metabolism_Homo sapiens_hsa003600.84786925
80Vibrio cholerae infection_Homo sapiens_hsa051100.84773008
81Small cell lung cancer_Homo sapiens_hsa052220.84093902
82Allograft rejection_Homo sapiens_hsa053300.83973453
83Prostate cancer_Homo sapiens_hsa052150.82722004
84Glutathione metabolism_Homo sapiens_hsa004800.82064072
85Tyrosine metabolism_Homo sapiens_hsa003500.80973615
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80579828
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79793425
88Arginine and proline metabolism_Homo sapiens_hsa003300.79668759
89Carbon metabolism_Homo sapiens_hsa012000.79550360
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.79305165
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78829819
92Antigen processing and presentation_Homo sapiens_hsa046120.78472127
93Apoptosis_Homo sapiens_hsa042100.78348552
94Renin-angiotensin system_Homo sapiens_hsa046140.76482543
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75908649
96One carbon pool by folate_Homo sapiens_hsa006700.75720735
97Prolactin signaling pathway_Homo sapiens_hsa049170.75611246
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75264453
99Nitrogen metabolism_Homo sapiens_hsa009100.73168677
100Herpes simplex infection_Homo sapiens_hsa051680.72831921
101Glucagon signaling pathway_Homo sapiens_hsa049220.72584674
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71920918
103Vitamin digestion and absorption_Homo sapiens_hsa049770.71880183
104Metabolic pathways_Homo sapiens_hsa011000.71224098
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71076448
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69846639
107Amoebiasis_Homo sapiens_hsa051460.69661459
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69315542
109Galactose metabolism_Homo sapiens_hsa000520.68663389
110Melanoma_Homo sapiens_hsa052180.67812629
111Arginine biosynthesis_Homo sapiens_hsa002200.67669276
112beta-Alanine metabolism_Homo sapiens_hsa004100.67048429
113Chronic myeloid leukemia_Homo sapiens_hsa052200.64587540
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64246272
115Proteasome_Homo sapiens_hsa030500.64013065
116TGF-beta signaling pathway_Homo sapiens_hsa043500.63821604
117Mineral absorption_Homo sapiens_hsa049780.62617833
118ECM-receptor interaction_Homo sapiens_hsa045120.62331727
119Fatty acid metabolism_Homo sapiens_hsa012120.62261846
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61438271
121Rheumatoid arthritis_Homo sapiens_hsa053230.60073236
122RNA polymerase_Homo sapiens_hsa030200.59728488
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59715276
124Shigellosis_Homo sapiens_hsa051310.59661439
125Platelet activation_Homo sapiens_hsa046110.59451585
126Insulin resistance_Homo sapiens_hsa049310.59237358
127Ether lipid metabolism_Homo sapiens_hsa005650.59206095
128Acute myeloid leukemia_Homo sapiens_hsa052210.56144009
129Tight junction_Homo sapiens_hsa045300.54102842
130Focal adhesion_Homo sapiens_hsa045100.53869974
131Proteoglycans in cancer_Homo sapiens_hsa052050.52925705
132Nucleotide excision repair_Homo sapiens_hsa034200.52320989
133Lysosome_Homo sapiens_hsa041420.52213589
134Arachidonic acid metabolism_Homo sapiens_hsa005900.52130060
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.51939782
136Lysine degradation_Homo sapiens_hsa003100.50600351
137Collecting duct acid secretion_Homo sapiens_hsa049660.50524820
138Pancreatic cancer_Homo sapiens_hsa052120.50069717
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48348936
140Folate biosynthesis_Homo sapiens_hsa007900.46957859
141MicroRNAs in cancer_Homo sapiens_hsa052060.44166183
142Autoimmune thyroid disease_Homo sapiens_hsa053200.43800580
143p53 signaling pathway_Homo sapiens_hsa041150.43755708
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43586422
145mTOR signaling pathway_Homo sapiens_hsa041500.42740291
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40412990
147RNA transport_Homo sapiens_hsa030130.38159043
148Regulation of autophagy_Homo sapiens_hsa041400.37103355
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36417976
150Pancreatic secretion_Homo sapiens_hsa049720.36396426
151Oxidative phosphorylation_Homo sapiens_hsa001900.35169555
152Hippo signaling pathway_Homo sapiens_hsa043900.33465717
153AMPK signaling pathway_Homo sapiens_hsa041520.33381798
154Purine metabolism_Homo sapiens_hsa002300.32275295
155Oocyte meiosis_Homo sapiens_hsa041140.30689034
156Pentose phosphate pathway_Homo sapiens_hsa000300.30439391
157Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30096400
158Renal cell carcinoma_Homo sapiens_hsa052110.28148113
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26924496
160Insulin secretion_Homo sapiens_hsa049110.26549257
161Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25051975

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