CPNE5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. More variants may exist, but their full-length natures could not be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.78911263
2vocalization behavior (GO:0071625)5.32080698
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30312949
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22630781
5regulation of glutamate receptor signaling pathway (GO:1900449)4.99147419
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.70427507
7protein localization to synapse (GO:0035418)4.67089671
8synaptic transmission, dopaminergic (GO:0001963)4.61789635
9locomotory exploration behavior (GO:0035641)4.55639471
10regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53777395
11synaptic vesicle maturation (GO:0016188)4.53252384
12regulation of synapse structural plasticity (GO:0051823)4.45302652
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42587763
14synaptic vesicle exocytosis (GO:0016079)4.42192304
15striatum development (GO:0021756)4.42083471
16positive regulation of synaptic transmission, GABAergic (GO:0032230)4.40242173
17prepulse inhibition (GO:0060134)4.31292350
18regulation of neuronal synaptic plasticity (GO:0048168)4.29295431
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.26277321
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.23993663
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.22540858
22regulation of synaptic vesicle exocytosis (GO:2000300)4.20515193
23neuron-neuron synaptic transmission (GO:0007270)4.20246568
24neurotransmitter-gated ion channel clustering (GO:0072578)4.19971633
25synaptic transmission, glutamatergic (GO:0035249)4.17325745
26positive regulation of neurotransmitter transport (GO:0051590)4.16872457
27auditory behavior (GO:0031223)4.13578345
28response to amphetamine (GO:0001975)4.10378523
29glutamate receptor signaling pathway (GO:0007215)4.07945786
30neutrophil activation involved in immune response (GO:0002283)4.07606724
31positive regulation of neurotransmitter secretion (GO:0001956)4.05505666
32neuron cell-cell adhesion (GO:0007158)4.03908303
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.98496415
34cAMP catabolic process (GO:0006198)3.96058167
35dendritic spine morphogenesis (GO:0060997)3.94036808
36positive regulation of membrane potential (GO:0045838)3.92308586
37response to auditory stimulus (GO:0010996)3.92033711
38adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.91861884
39positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.89657154
40behavioral response to cocaine (GO:0048148)3.89497368
41long-term memory (GO:0007616)3.87836214
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.86655187
43neuronal action potential propagation (GO:0019227)3.84587773
44B cell receptor signaling pathway (GO:0050853)3.84212786
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83843433
46regulation of synaptic vesicle transport (GO:1902803)3.83460874
47transmission of nerve impulse (GO:0019226)3.81059692
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80543802
49regulation of platelet aggregation (GO:0090330)3.79485901
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.77972310
51regulation of glutamate secretion (GO:0014048)3.75240815
52regulation of postsynaptic membrane potential (GO:0060078)3.74400595
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72004776
54neurotransmitter secretion (GO:0007269)3.69904961
55L-amino acid import (GO:0043092)3.64095297
56glutamate secretion (GO:0014047)3.63912059
57adenosine receptor signaling pathway (GO:0001973)3.58949951
58regulation of dendritic spine morphogenesis (GO:0061001)3.58927812
59positive regulation of Rap GTPase activity (GO:0032854)3.56415698
60cyclic nucleotide catabolic process (GO:0009214)3.55638445
61exploration behavior (GO:0035640)3.54222730
62regulation of B cell receptor signaling pathway (GO:0050855)3.53729620
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.52605530
64dopamine receptor signaling pathway (GO:0007212)3.51543646
65regulation of synaptic transmission, GABAergic (GO:0032228)3.50432084
66regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.48388674
67regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.48388674
68startle response (GO:0001964)3.46147537
69negative regulation of cytosolic calcium ion concentration (GO:0051481)3.44920001
70regulation of synaptic plasticity (GO:0048167)3.44273700
71long-term synaptic potentiation (GO:0060291)3.44035878
72neuronal ion channel clustering (GO:0045161)3.44030276
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43551510
74negative regulation of cell killing (GO:0031342)3.43551510
75activation of protein kinase A activity (GO:0034199)3.42778661
76visual learning (GO:0008542)3.42202291
77negative regulation of dendrite development (GO:2000171)3.41054244
78regulation of voltage-gated calcium channel activity (GO:1901385)3.37160656
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.35613155
80learning (GO:0007612)3.35018735
81mechanosensory behavior (GO:0007638)3.34549278
82leukocyte migration involved in inflammatory response (GO:0002523)3.33171648
83membrane hyperpolarization (GO:0060081)3.29756245
84sodium ion export (GO:0071436)3.28002554
85regulation of neurotransmitter secretion (GO:0046928)3.27594387
86behavioral fear response (GO:0001662)3.26465859
87behavioral defense response (GO:0002209)3.26465859
88postsynaptic membrane organization (GO:0001941)3.25295255
89regulation of neurotransmitter transport (GO:0051588)3.25169718
90G-protein coupled receptor internalization (GO:0002031)3.23816043
91positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22369690
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.22207128
93visual behavior (GO:0007632)3.21377534
94membrane depolarization (GO:0051899)3.21101291
95drinking behavior (GO:0042756)3.20724194
96regulation of female receptivity (GO:0045924)3.20095104
97regulation of Rap GTPase activity (GO:0032317)3.19447788
98negative regulation of amino acid transport (GO:0051956)3.18418449
99regulation of T-helper 2 cell differentiation (GO:0045628)3.17730592
100response to histamine (GO:0034776)3.16416745
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15419143
102regulation of neurotransmitter uptake (GO:0051580)3.14153887
103gamma-aminobutyric acid transport (GO:0015812)3.12228001
104regulation of vesicle fusion (GO:0031338)3.09284292
105positive regulation of mast cell activation (GO:0033005)3.09165395
106presynaptic membrane assembly (GO:0097105)3.09012434
107female mating behavior (GO:0060180)3.08884969
108negative regulation of dendrite morphogenesis (GO:0050774)3.08233076
109positive regulation of synaptic transmission (GO:0050806)3.07958938
110associative learning (GO:0008306)3.06208885
111cerebellar granule cell differentiation (GO:0021707)3.05276709
112cell communication by electrical coupling (GO:0010644)3.04510856
113neurotransmitter transport (GO:0006836)3.04443146
114substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.04029377
115substrate-independent telencephalic tangential migration (GO:0021826)3.04029377
116neuromuscular process controlling balance (GO:0050885)3.03326663
117glycine transport (GO:0015816)3.02703293
118dendritic spine organization (GO:0097061)3.02275321
119cAMP metabolic process (GO:0046058)3.01974965
120synaptic vesicle endocytosis (GO:0048488)3.01429412
121regulation of ARF protein signal transduction (GO:0032012)2.95041101
122positive regulation of gamma-delta T cell activation (GO:0046645)2.95004775
123cellular potassium ion homeostasis (GO:0030007)2.93721571
124negative regulation of heart contraction (GO:0045822)2.89076638
125negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88398208
126germinal center formation (GO:0002467)2.87690675
127G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.82335779
128regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.81993204
129thrombin receptor signaling pathway (GO:0070493)2.78736985
130regulation of platelet activation (GO:0010543)2.77399610
131signal complex assembly (GO:0007172)2.75265997
132antigen processing and presentation of endogenous antigen (GO:0019883)2.73576361
133negative regulation of heart rate (GO:0010459)2.72266755
134amino acid import (GO:0043090)2.72050003
135negative regulation of T-helper cell differentiation (GO:0045623)2.70665151
136negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.70665151
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.69853673
138purinergic receptor signaling pathway (GO:0035587)2.69276740
139negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66057358
140regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.63871494
141detection of calcium ion (GO:0005513)2.60888296
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60725352
143neutrophil activation (GO:0042119)2.60427904
144positive regulation of type 2 immune response (GO:0002830)2.55341444
145cellular response to epinephrine stimulus (GO:0071872)2.53987651
146positive regulation of fibroblast migration (GO:0010763)2.48817999
147regulation of inositol phosphate biosynthetic process (GO:0010919)2.48266541
148regulation of mast cell degranulation (GO:0043304)2.45244807
149platelet aggregation (GO:0070527)2.45051149
150positive regulation of synapse maturation (GO:0090129)2.42978650
151regulation of amyloid precursor protein catabolic process (GO:1902991)2.42433042
152regulation of calcium ion transmembrane transporter activity (GO:1901019)2.42115832
153regulation of calcium ion transmembrane transport (GO:1903169)2.42115832
154angiogenesis involved in wound healing (GO:0060055)2.42051689
155positive regulation of mast cell degranulation (GO:0043306)2.41715690
156positive regulation of mast cell activation involved in immune response (GO:0033008)2.41715690
157megakaryocyte development (GO:0035855)2.41510568
158potassium ion import (GO:0010107)2.41071371
159regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.39993623
160activation of phospholipase C activity (GO:0007202)2.38808616
161positive regulation of cellular amide metabolic process (GO:0034250)2.38333604
162negative regulation of homotypic cell-cell adhesion (GO:0034111)2.34144657
163actin filament polymerization (GO:0030041)2.34045273
164positive regulation of B cell differentiation (GO:0045579)2.32898349
165positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.32802875
166regulation of regulated secretory pathway (GO:1903305)2.31102933
167positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30066505
168regulation of mast cell activation involved in immune response (GO:0033006)2.29139509
169regulation of myeloid leukocyte mediated immunity (GO:0002886)2.28110120
170macrophage activation involved in immune response (GO:0002281)2.28013752
171vesicle docking involved in exocytosis (GO:0006904)2.27493341
172membrane depolarization during action potential (GO:0086010)2.26909136
173myeloid cell activation involved in immune response (GO:0002275)2.26859663

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.71696089
2GBX2_23144817_ChIP-Seq_PC3_Human4.05538308
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.01083028
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99841784
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96175534
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75972104
7* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.73525618
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55409252
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.54893914
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54659902
11REST_21632747_ChIP-Seq_MESCs_Mouse2.49908100
12* RARB_27405468_Chip-Seq_BRAIN_Mouse2.49331640
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44856305
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44856305
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34651442
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33527932
17DROSHA_22980978_ChIP-Seq_HELA_Human2.31537865
18SCL_19346495_ChIP-Seq_HPC-7_Human2.31471053
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30305492
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.25638096
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24071904
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20432175
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.19584318
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18493050
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.14907734
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12685229
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12326059
28* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.10360832
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09132334
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06797066
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05906080
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03594900
33AR_21572438_ChIP-Seq_LNCaP_Human2.02276054
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00376065
35TAF15_26573619_Chip-Seq_HEK293_Human1.99385982
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98315329
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96810706
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.94933052
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93539359
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92951743
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87912011
42SPI1_23127762_ChIP-Seq_K562_Human1.83547868
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.83491425
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81230701
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.77182410
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73665043
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71661840
48GATA1_19941826_ChIP-Seq_K562_Human1.71640929
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69796480
50SMAD4_21799915_ChIP-Seq_A2780_Human1.68295382
51RUNX_20019798_ChIP-Seq_JUKART_Human1.67061786
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.61949074
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58833344
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58556919
55* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58412608
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.58347703
57P300_19829295_ChIP-Seq_ESCs_Human1.58282253
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.57292500
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56509731
60MYC_22102868_ChIP-Seq_BL_Human1.54213945
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53764829
62RNF2_27304074_Chip-Seq_NSC_Mouse1.50612146
63LXR_22292898_ChIP-Seq_THP-1_Human1.47489535
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46415808
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44268807
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43144868
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.41893466
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41194209
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38847141
70TCF7_22412390_ChIP-Seq_EML_Mouse1.37994537
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37991933
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37949013
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37657540
74KDM2B_26808549_Chip-Seq_DND41_Human1.35915337
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35065583
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.34441233
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.34024307
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32653725
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.31897575
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30860967
81STAT3_23295773_ChIP-Seq_U87_Human1.30085149
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.29917321
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28561842
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28489098
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.26733267
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26285409
87* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25995803
88* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24987299
89GATA2_19941826_ChIP-Seq_K562_Human1.23922178
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.23713970
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23625743
92TCF4_23295773_ChIP-Seq_U87_Human1.22728127
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22000111
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21482050
95P53_22387025_ChIP-Seq_ESCs_Mouse1.21029144
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21003123
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20350904
98* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20268908
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19334251
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18938417
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.18185272
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17914070
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17258650
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16853709
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16496303
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.15172208
107GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14842883
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.14669109
109* KDM2B_26808549_Chip-Seq_K562_Human1.14656760
110AR_25329375_ChIP-Seq_VCAP_Human1.14164243
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.13901422
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13739573
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13739573
114* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13285756
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.12472231
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.12072670
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12059558
118ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11643171
119* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10978459
120FUS_26573619_Chip-Seq_HEK293_Human1.10805758
121RING1B_27294783_Chip-Seq_ESCs_Mouse1.10511525
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10285206
123IGF1R_20145208_ChIP-Seq_DFB_Human1.10263896
124NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09188766
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.07937653
126SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07659782
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.07294713
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06573594
129SOX2_18555785_Chip-Seq_ESCs_Mouse1.06163516
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05368469
131UTX_26944678_Chip-Seq_JUKART_Human1.05114940
132P300_18555785_Chip-Seq_ESCs_Mouse1.04394363
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03570957
134VDR_24763502_ChIP-Seq_THP-1_Human1.03279713
135* AR_19668381_ChIP-Seq_PC3_Human1.03243969
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02639863
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.02620036
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.02058087
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00866389
140GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00073075
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.99317161
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.98450262
143VDR_22108803_ChIP-Seq_LS180_Human0.98267005
144RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98005027
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.97877187
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97778794
147* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97667928
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97583852
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.97105017
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96932474
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96327542
152* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96085227
153KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95431602
154MAF_26560356_Chip-Seq_TH1_Human0.94348513
155KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92225682
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90812413
157GATA1_22025678_ChIP-Seq_K562_Human0.90670553
158BCOR_27268052_Chip-Seq_Bcells_Human0.90339277
159SMC4_20622854_ChIP-Seq_HELA_Human0.89480689
160KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89202458
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88064144
162BCL6_27268052_Chip-Seq_Bcells_Human0.88000057
163CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86854218
164OCT4_19829295_ChIP-Seq_ESCs_Human0.85680861
165CTCF_27219007_Chip-Seq_Bcells_Human0.81400120
166EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.80645847
167CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80135525
168SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80035436
169P68_20966046_ChIP-Seq_HELA_Human0.79680098
170PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79653483
171VDR_21846776_ChIP-Seq_THP-1_Human0.79407647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.28732770
2MP0004859_abnormal_synaptic_plasticity5.52213775
3MP0003880_abnormal_central_pattern4.32280347
4MP0005464_abnormal_platelet_physiology4.15438999
5MP0003635_abnormal_synaptic_transmissio3.79248709
6MP0009745_abnormal_behavioral_response3.56154792
7MP0002063_abnormal_learning/memory/cond3.22337748
8MP0003303_peritoneal_inflammation3.04904800
9MP0009046_muscle_twitch2.98631693
10MP0002064_seizures2.89249876
11MP0001486_abnormal_startle_reflex2.88928516
12MP0005423_abnormal_somatic_nervous2.81912654
13MP0001968_abnormal_touch/_nociception2.81080227
14MP0002572_abnormal_emotion/affect_behav2.81008507
15MP0001188_hyperpigmentation2.77117469
16MP0004270_analgesia2.73227801
17MP0003724_increased_susceptibility_to2.72491638
18MP0001529_abnormal_vocalization2.58905149
19MP0008004_abnormal_stomach_pH2.55854690
20MP0005646_abnormal_pituitary_gland2.48174603
21MP0002272_abnormal_nervous_system2.44636750
22MP0001501_abnormal_sleep_pattern2.35244823
23MP0001835_abnormal_antigen_presentation2.26211515
24MP0005409_darkened_coat_color2.21550110
25MP0002736_abnormal_nociception_after2.18450490
26MP0002734_abnormal_mechanical_nocicepti2.16474688
27MP0004084_abnormal_cardiac_muscle2.08809422
28MP0003787_abnormal_imprinting2.00907550
29MP0005671_abnormal_response_to1.99747850
30MP0001790_abnormal_immune_system1.99310917
31MP0005387_immune_system_phenotype1.99310917
32MP0000465_gastrointestinal_hemorrhage1.98812572
33MP0001984_abnormal_olfaction1.96737003
34MP0001800_abnormal_humoral_immune1.96368127
35MP0002557_abnormal_social/conspecific_i1.91174746
36MP0005000_abnormal_immune_tolerance1.89674826
37MP0005645_abnormal_hypothalamus_physiol1.83864701
38MP0002735_abnormal_chemical_nociception1.82138753
39MP0001970_abnormal_pain_threshold1.80136124
40MP0004036_abnormal_muscle_relaxation1.76623005
41MP0006292_abnormal_olfactory_placode1.75668376
42MP0002067_abnormal_sensory_capabilities1.72871510
43MP0005386_behavior/neurological_phenoty1.70769952
44MP0004924_abnormal_behavior1.70769952
45MP0002733_abnormal_thermal_nociception1.70425558
46MP0003436_decreased_susceptibility_to1.67309271
47MP0003879_abnormal_hair_cell1.67045743
48MP0001440_abnormal_grooming_behavior1.66951441
49MP0000685_abnormal_immune_system1.61724036
50MP0003183_abnormal_peptide_metabolism1.60090641
51MP0002723_abnormal_immune_serum1.51501225
52MP0004130_abnormal_muscle_cell1.49873800
53MP0002184_abnormal_innervation1.48737737
54MP0008569_lethality_at_weaning1.48003674
55MP0002452_abnormal_antigen_presenting1.45525690
56MP0003690_abnormal_glial_cell1.45449183
57MP0002420_abnormal_adaptive_immunity1.43722925
58MP0003329_amyloid_beta_deposits1.42711879
59MP0001905_abnormal_dopamine_level1.39896479
60MP0001819_abnormal_immune_cell1.38711360
61MP0004811_abnormal_neuron_physiology1.37565318
62MP0006276_abnormal_autonomic_nervous1.37303850
63MP0002398_abnormal_bone_marrow1.36861941
64MP0003828_pulmonary_edema1.35266811
65MP0001502_abnormal_circadian_rhythm1.35140738
66MP0004215_abnormal_myocardial_fiber1.34774955
67MP0000778_abnormal_nervous_system1.30175572
68MP0000569_abnormal_digit_pigmentation1.29208750
69MP0005310_abnormal_salivary_gland1.24360928
70MP0003763_abnormal_thymus_physiology1.22533332
71MP0005025_abnormal_response_to1.21818468
72MP0010386_abnormal_urinary_bladder1.21511132
73MP0004142_abnormal_muscle_tone1.19038342
74MP0010155_abnormal_intestine_physiology1.18985224
75MP0002638_abnormal_pupillary_reflex1.18683174
76MP0002066_abnormal_motor_capabilities/c1.17325831
77MP0001177_atelectasis1.16130878
78MP0002882_abnormal_neuron_morphology1.16124340
79MP0004484_altered_response_of1.14790292
80MP0002419_abnormal_innate_immunity1.14638723
81MP0000955_abnormal_spinal_cord1.14422201
82MP0002909_abnormal_adrenal_gland1.11980727
83MP0001986_abnormal_taste_sensitivity1.11008388
84MP0003866_abnormal_defecation1.10884217
85MP0000716_abnormal_immune_system1.10527881
86MP0000920_abnormal_myelination1.10450220
87MP0005394_taste/olfaction_phenotype1.09868838
88MP0005499_abnormal_olfactory_system1.09868838
89MP0001851_eye_inflammation1.09782455
90MP0008872_abnormal_physiological_respon1.07253302
91MP0002148_abnormal_hypersensitivity_rea1.06528038
92MP0000343_altered_response_to1.05850364
93MP0004742_abnormal_vestibular_system1.05672341
94MP0005166_decreased_susceptibility_to1.04558213
95MP0009780_abnormal_chondrocyte_physiolo1.04126611
96MP0008260_abnormal_autophagy1.02945795
97MP0003045_fibrosis1.02943942
98MP0003172_abnormal_lysosome_physiology1.02908327
99MP0005551_abnormal_eye_electrophysiolog1.01943768
100MP0008775_abnormal_heart_ventricle1.01599950
101MP0000631_abnormal_neuroendocrine_gland0.99671819
102MP0002972_abnormal_cardiac_muscle0.97009871
103MP0000015_abnormal_ear_pigmentation0.96523897
104MP0008877_abnormal_DNA_methylation0.95463882
105MP0003300_gastrointestinal_ulcer0.94722985
106MP0003633_abnormal_nervous_system0.93026954
107MP0004947_skin_inflammation0.91616765
108MP0008874_decreased_physiological_sensi0.91542741
109MP0000689_abnormal_spleen_morphology0.91131451
110MP0001963_abnormal_hearing_physiology0.89507517
111MP0002429_abnormal_blood_cell0.89212938
112MP0005171_absent_coat_pigmentation0.88228252
113MP0003122_maternal_imprinting0.88126105
114MP0004885_abnormal_endolymph0.87693242
115MP0002069_abnormal_eating/drinking_beha0.87384176
116MP0000230_abnormal_systemic_arterial0.86785468
117MP0002876_abnormal_thyroid_physiology0.86479117
118MP0002837_dystrophic_cardiac_calcinosis0.86347967
119MP0002152_abnormal_brain_morphology0.84442510
120MP0001544_abnormal_cardiovascular_syste0.83306979
121MP0005385_cardiovascular_system_phenoty0.83306979
122MP0001533_abnormal_skeleton_physiology0.83061795
123MP0000249_abnormal_blood_vessel0.81219591
124MP0002102_abnormal_ear_morphology0.81056844
125MP0001663_abnormal_digestive_system0.80743756
126MP0003631_nervous_system_phenotype0.79147800
127MP0001845_abnormal_inflammatory_respons0.78614284
128MP0004085_abnormal_heartbeat0.78493261
129MP0002722_abnormal_immune_system0.78268370
130MP0003136_yellow_coat_color0.75920892
131MP0002752_abnormal_somatic_nervous0.73880937
132MP0003638_abnormal_response/metabolism_0.73432422
133MP0005535_abnormal_body_temperature0.70606868
134MP0001664_abnormal_digestion0.70557766
135MP0000604_amyloidosis0.69866977
136MP0002229_neurodegeneration0.69136815
137MP0003075_altered_response_to0.68490557
138MP0001485_abnormal_pinna_reflex0.68248876
139MP0000026_abnormal_inner_ear0.67635000
140MP0005174_abnormal_tail_pigmentation0.66709262
141MP0002090_abnormal_vision0.62985251
142MP0004858_abnormal_nervous_system0.59114069
143MP0008961_abnormal_basal_metabolism0.59014515
144MP0004510_myositis0.53138186
145MP0005167_abnormal_blood-brain_barrier0.52330933
146MP0002277_abnormal_respiratory_mucosa0.51687182
147MP0000566_synostosis0.50709251
148MP0008995_early_reproductive_senescence0.50557164
149MP0003137_abnormal_impulse_conducting0.48497988
150MP0005379_endocrine/exocrine_gland_phen0.47795045
151MP0002163_abnormal_gland_morphology0.47710687
152MP0003121_genomic_imprinting0.47147535
153MP0005253_abnormal_eye_physiology0.46610863
154MP0006072_abnormal_retinal_apoptosis0.43543475
155MP0003698_abnormal_male_reproductive0.43249885
156MP0001943_abnormal_respiration0.42296777
157MP0000681_abnormal_thyroid_gland0.41211889
158MP0010770_preweaning_lethality0.40387779
159MP0002082_postnatal_lethality0.40387779

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.72608266
2Myokymia (HP:0002411)6.67378527
3Prolonged bleeding time (HP:0003010)6.66303402
4Menorrhagia (HP:0000132)5.27874603
5Petechiae (HP:0000967)5.27133217
6Febrile seizures (HP:0002373)5.24717330
7Purpura (HP:0000979)5.23557197
8Focal seizures (HP:0007359)5.23517369
9Abnormal platelet volume (HP:0011876)5.12843865
10Increased mean platelet volume (HP:0011877)4.95610905
11Epistaxis (HP:0000421)4.49589063
12Epileptic encephalopathy (HP:0200134)4.42735885
13Abnormality of binocular vision (HP:0011514)4.37658893
14Diplopia (HP:0000651)4.37658893
15Agammaglobulinemia (HP:0004432)3.89242105
16Gingival bleeding (HP:0000225)3.86809366
17Spontaneous hematomas (HP:0007420)3.75536686
18Visual hallucinations (HP:0002367)3.55667003
19Broad-based gait (HP:0002136)3.51922278
20Generalized tonic-clonic seizures (HP:0002069)3.49272136
21Gastrointestinal stroma tumor (HP:0100723)3.42298672
22Hyperlipoproteinemia (HP:0010980)3.35118749
23Ventricular fibrillation (HP:0001663)3.31318944
24Progressive cerebellar ataxia (HP:0002073)3.30240677
25Atonic seizures (HP:0010819)3.29538377
26Absent/shortened dynein arms (HP:0200106)3.17836118
27Dynein arm defect of respiratory motile cilia (HP:0012255)3.17836118
28Gaze-evoked nystagmus (HP:0000640)3.16290679
29Absence seizures (HP:0002121)3.12292307
30Hemiplegia (HP:0002301)3.09494581
31Cellulitis (HP:0100658)3.08388486
32Poor eye contact (HP:0000817)3.06703809
33Dialeptic seizures (HP:0011146)3.05402068
34Eczematoid dermatitis (HP:0000976)3.02275116
35Meningitis (HP:0001287)2.82442042
36Bundle branch block (HP:0011710)2.82302843
37Abnormal platelet function (HP:0011869)2.81040316
38Impaired platelet aggregation (HP:0003540)2.81040316
39Torticollis (HP:0000473)2.80994165
40Anxiety (HP:0000739)2.80221848
41Abnormality of macrophages (HP:0004311)2.77748771
42Hyperventilation (HP:0002883)2.67334146
43Impaired vibration sensation in the lower limbs (HP:0002166)2.66065772
44Abnormal ciliary motility (HP:0012262)2.64532709
45Abnormal hair whorl (HP:0010721)2.60765701
46Limb dystonia (HP:0002451)2.59907970
47Ankle clonus (HP:0011448)2.59449806
48Sudden death (HP:0001699)2.56069118
49Urinary bladder sphincter dysfunction (HP:0002839)2.53018637
50Abnormal social behavior (HP:0012433)2.51502137
51Impaired social interactions (HP:0000735)2.51502137
52Stereotypic behavior (HP:0000733)2.47516716
53Focal dystonia (HP:0004373)2.47451255
54Action tremor (HP:0002345)2.46389889
55Fetal akinesia sequence (HP:0001989)2.45620423
56Atrial fibrillation (HP:0005110)2.45495050
57Lower limb amyotrophy (HP:0007210)2.44929598
58Annular pancreas (HP:0001734)2.42468531
59Dysdiadochokinesis (HP:0002075)2.41577433
60Primary atrial arrhythmia (HP:0001692)2.41507742
61Inflammation of the large intestine (HP:0002037)2.40157605
62Obstructive lung disease (HP:0006536)2.38116356
63Chronic obstructive pulmonary disease (HP:0006510)2.38116356
64Abnormal respiratory motile cilium morphology (HP:0005938)2.37529872
65Abnormal respiratory epithelium morphology (HP:0012253)2.37529872
66Vasculitis (HP:0002633)2.36694857
67Hyporeflexia of lower limbs (HP:0002600)2.36201942
68Gastrointestinal inflammation (HP:0004386)2.34358097
69Syncope (HP:0001279)2.33820792
70Supraventricular tachycardia (HP:0004755)2.31498620
71Recurrent bacterial skin infections (HP:0005406)2.30839341
72Encephalitis (HP:0002383)2.30246880
73Gait imbalance (HP:0002141)2.29477545
74Protruding tongue (HP:0010808)2.29415457
75Depression (HP:0000716)2.29015298
76Truncal ataxia (HP:0002078)2.28096851
77Progressive inability to walk (HP:0002505)2.27423252
78Craniofacial dystonia (HP:0012179)2.27082406
79Abnormal eating behavior (HP:0100738)2.26725414
80Recurrent sinusitis (HP:0011108)2.25577857
81Absent speech (HP:0001344)2.24969002
82Colitis (HP:0002583)2.24283463
83Supraventricular arrhythmia (HP:0005115)2.23893567
84Recurrent abscess formation (HP:0002722)2.22688469
85Abnormal EKG (HP:0003115)2.21925906
86Dysmetria (HP:0001310)2.20080800
87Panhypogammaglobulinemia (HP:0003139)2.20052937
88Papilloma (HP:0012740)2.19451567
89Verrucae (HP:0200043)2.19451567
90Medial flaring of the eyebrow (HP:0010747)2.19392638
91Inability to walk (HP:0002540)2.17714159
92Abnormal respiratory motile cilium physiology (HP:0012261)2.15433058
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14471407
94Osteomyelitis (HP:0002754)2.13085505
95Chest pain (HP:0100749)2.12091654
96Sleep apnea (HP:0010535)2.11028063
97Heart block (HP:0012722)2.08961520
98Congenital primary aphakia (HP:0007707)2.08795753
99Scanning speech (HP:0002168)2.07706999
100Mediastinal lymphadenopathy (HP:0100721)2.07355143
101Muscle fiber splitting (HP:0003555)2.07150912
102Prolonged QT interval (HP:0001657)2.06953893
103Amblyopia (HP:0000646)2.06503631
104Nephrogenic diabetes insipidus (HP:0009806)2.06481362
105Tetraplegia (HP:0002445)2.06237786
106Vertigo (HP:0002321)2.05279589
107Peripheral hypomyelination (HP:0007182)2.04510684
108Emphysema (HP:0002097)2.03605033
109Distal lower limb amyotrophy (HP:0008944)2.02912093
110Obstructive sleep apnea (HP:0002870)2.02417073
111Stomatitis (HP:0010280)1.99727470
112Neuronal loss in central nervous system (HP:0002529)1.98576809
113Mutism (HP:0002300)1.98533605
114Deeply set eye (HP:0000490)1.98472628
115Ankyloglossia (HP:0010296)1.97811736
116Pointed chin (HP:0000307)1.97264260
117Lymphopenia (HP:0001888)1.97020232
118Anomalous pulmonary venous return (HP:0010772)1.96444706
119Absent eyebrow (HP:0002223)1.96369457
120Impaired vibratory sensation (HP:0002495)1.95710274
121Postural instability (HP:0002172)1.94147795
122Testicular neoplasm (HP:0010788)1.92916525
123Generalized hypopigmentation of hair (HP:0011358)1.91859205
124Ventricular arrhythmia (HP:0004308)1.91394175
125Excessive salivation (HP:0003781)1.91322672
126Drooling (HP:0002307)1.91322672
127Recurrent gram-negative bacterial infections (HP:0005420)1.90724719
128Poikilocytosis (HP:0004447)1.90703615
129Incomplete penetrance (HP:0003829)1.90218633
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.89702967
131Impaired smooth pursuit (HP:0007772)1.89506546
132Hemiparesis (HP:0001269)1.87434714
133Episodic fever (HP:0001954)1.86784752
134Bradykinesia (HP:0002067)1.85447167
135Abnormal atrioventricular conduction (HP:0005150)1.84924257
136Recurrent bronchitis (HP:0002837)1.84843078
137Resting tremor (HP:0002322)1.83918745
138Lower limb muscle weakness (HP:0007340)1.83521484
139Cerebral inclusion bodies (HP:0100314)1.83219850
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83024655
141Bruising susceptibility (HP:0000978)1.81807890
142Memory impairment (HP:0002354)1.81492374
143Acute lymphatic leukemia (HP:0006721)1.81378677
144Neurofibrillary tangles (HP:0002185)1.80894639
145Polyphagia (HP:0002591)1.80337910
146Genital tract atresia (HP:0001827)1.79886169
147Delusions (HP:0000746)1.79797584
148Slow saccadic eye movements (HP:0000514)1.79727825
149Papilledema (HP:0001085)1.79419028
150Epileptiform EEG discharges (HP:0011182)1.79170406
151Increased IgE level (HP:0003212)1.78223974
152Genetic anticipation (HP:0003743)1.77837083
153Abnormality of cells of the lymphoid lineage (HP:0012140)1.77804056
154Vaginal atresia (HP:0000148)1.76712627
155Gastroesophageal reflux (HP:0002020)1.76694670
156Palpebral edema (HP:0100540)1.73417236
157Blue irides (HP:0000635)1.73022142
158Chromsome breakage (HP:0040012)1.68806584
159Fair hair (HP:0002286)1.66880163
160EEG with generalized epileptiform discharges (HP:0011198)1.66806650
161Iris hypopigmentation (HP:0007730)1.66166679
162Specific learning disability (HP:0001328)1.65372730
163Supranuclear gaze palsy (HP:0000605)1.64937786
164Urinary urgency (HP:0000012)1.63833530
165Nephronophthisis (HP:0000090)1.61021749
166Abnormality of ocular smooth pursuit (HP:0000617)1.60297285
167Generalized myoclonic seizures (HP:0002123)1.59886298
168Cutaneous finger syndactyly (HP:0010554)1.59690629
169True hermaphroditism (HP:0010459)1.58780023
170Poor coordination (HP:0002370)1.58197455
171Spastic gait (HP:0002064)1.57902055
172Autism (HP:0000717)1.57424975
173Failure to thrive in infancy (HP:0001531)1.53498909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.36058002
2NTRK34.19854663
3RIPK42.85682131
4MAP4K12.79694971
5MAP2K72.78847102
6TNIK2.70370562
7MAP3K92.64608006
8CASK2.58256402
9DAPK22.54539496
10MAP3K42.22347294
11SYK2.12823276
12BLK2.08213290
13NTRK22.03940630
14ERN11.95082383
15PRPF4B1.94757662
16MARK11.90972316
17BTK1.86392032
18BMPR21.84158438
19MINK11.79083981
20BMX1.75864788
21MAP3K131.71345914
22SIK21.70781686
23MAP3K121.68475235
24FES1.63907718
25MAPK121.61293523
26PRKD31.59821071
27MYLK1.55639593
28MAPK131.55271947
29DAPK11.54431455
30CAMKK11.46138944
31SGK21.38584710
32CDK51.37914712
33SIK31.37680561
34MAP3K111.29597952
35TEC1.29047107
36PAK61.28897338
37ARAF1.28117438
38NEK61.27473027
39PLK21.27431437
40TNK21.25991230
41KSR21.22164369
42KSR11.22155403
43GRK61.18465012
44SGK2231.17133137
45SGK4941.17133137
46MAP2K41.13199345
47CSF1R1.12563940
48ZAP701.10445746
49ADRBK21.07825868
50PINK11.06246253
51PDPK11.04217461
52GRK51.03142122
53STK380.99225099
54PRKCG0.99207048
55CSK0.96995745
56AKT30.96183070
57LYN0.96119925
58CAMK10.94299870
59CAMK2A0.93914498
60NTRK10.92037054
61SGK10.91963501
62TAOK10.91492842
63PAK30.91015176
64SGK30.88041369
65MUSK0.87904551
66IRAK40.87677064
67PKN10.87196364
68MAP3K20.86214278
69ITK0.85171310
70JAK10.84235580
71CAMKK20.83918781
72PRKD10.80821617
73MAP2K30.80242380
74MAP3K100.76011948
75MARK20.75203677
76PRKCH0.75013108
77UHMK10.74072476
78CCNB10.73880339
79JAK20.72755220
80RIPK10.72228292
81ZAK0.72004288
82CDK30.71975285
83RAF10.68897067
84STK110.67514954
85PRKCE0.67439338
86MAP3K10.66984769
87CAMK2B0.66002239
88RET0.64979235
89MST40.63774579
90DYRK1A0.63121927
91PRKCQ0.59681480
92TYRO30.59433134
93DAPK30.59113377
94PTK2B0.57832951
95CDK180.57723234
96BRAF0.57404538
97TYK20.55884980
98MAP3K50.53192044
99PNCK0.52825149
100CDK150.51626690
101CAMK40.50692235
102YES10.50225621
103ERBB30.48483872
104LCK0.47805957
105CLK10.46988145
106ROCK10.46342566
107GRK10.46066429
108LMTK20.45632932
109GRK70.45589732
110CDK11A0.44599893
111FGR0.43738807
112TAOK30.43179273
113TXK0.43026362
114MAP2K10.42835292
115MAPK100.41521685
116IRAK20.41491582
117MAPK40.41472751
118EIF2AK20.41305905
119CDK190.41234384
120PRKCZ0.40343210
121CDK140.40235536
122RPS6KA30.39360277
123MAPK70.38739491
124CDC42BPA0.37934427
125CAMK2D0.37878690
126PRKACA0.37702593
127FYN0.37409007
128NME10.37331762
129JAK30.37231994
130DMPK0.36600153
131PRKD20.36228178
132EPHB10.35812559
133PRKCB0.35767074
134TAOK20.35482063
135PAK10.35166389
136STK160.35105978
137BCR0.33558652
138ALK0.33268687
139CSNK1A10.33185032
140PDK10.33084010
141HCK0.32870953
142MKNK20.32819999

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68265373
2Olfactory transduction_Homo sapiens_hsa047403.58399719
3Morphine addiction_Homo sapiens_hsa050323.03381078
4Synaptic vesicle cycle_Homo sapiens_hsa047212.94904414
5Circadian entrainment_Homo sapiens_hsa047132.78373805
6Amphetamine addiction_Homo sapiens_hsa050312.69576376
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65829915
8GABAergic synapse_Homo sapiens_hsa047272.63747150
9Glutamatergic synapse_Homo sapiens_hsa047242.57895043
10B cell receptor signaling pathway_Homo sapiens_hsa046622.38391635
11Long-term potentiation_Homo sapiens_hsa047202.35106683
12Cocaine addiction_Homo sapiens_hsa050302.27668612
13Dopaminergic synapse_Homo sapiens_hsa047282.20481478
14Taste transduction_Homo sapiens_hsa047422.10912849
15Serotonergic synapse_Homo sapiens_hsa047262.03557877
16Cholinergic synapse_Homo sapiens_hsa047252.02686129
17Salivary secretion_Homo sapiens_hsa049702.01708260
18Calcium signaling pathway_Homo sapiens_hsa040201.90152119
19Renin secretion_Homo sapiens_hsa049241.82711608
20Insulin secretion_Homo sapiens_hsa049111.81830640
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73444891
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70758860
23Oxytocin signaling pathway_Homo sapiens_hsa049211.66089078
24Phototransduction_Homo sapiens_hsa047441.63514878
25Gastric acid secretion_Homo sapiens_hsa049711.61110734
26Long-term depression_Homo sapiens_hsa047301.57293768
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52799373
28Primary immunodeficiency_Homo sapiens_hsa053401.52697241
29Collecting duct acid secretion_Homo sapiens_hsa049661.47025789
30Allograft rejection_Homo sapiens_hsa053301.42992479
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40046110
32cAMP signaling pathway_Homo sapiens_hsa040241.39739989
33GnRH signaling pathway_Homo sapiens_hsa049121.35263119
34Autoimmune thyroid disease_Homo sapiens_hsa053201.34758125
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29746139
36Osteoclast differentiation_Homo sapiens_hsa043801.27710786
37Leishmaniasis_Homo sapiens_hsa051401.25734854
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22547057
39Gap junction_Homo sapiens_hsa045401.20399564
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20324937
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18901453
42Hematopoietic cell lineage_Homo sapiens_hsa046401.12493886
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.11625931
44Asthma_Homo sapiens_hsa053101.09960412
45Type I diabetes mellitus_Homo sapiens_hsa049401.08984235
46Staphylococcus aureus infection_Homo sapiens_hsa051501.07786127
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05262085
48Viral myocarditis_Homo sapiens_hsa054161.05169019
49ErbB signaling pathway_Homo sapiens_hsa040120.98008373
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.94430078
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94133865
52Axon guidance_Homo sapiens_hsa043600.93151522
53Melanogenesis_Homo sapiens_hsa049160.91286251
54Type II diabetes mellitus_Homo sapiens_hsa049300.89442258
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88624696
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87457484
57Alcoholism_Homo sapiens_hsa050340.86054559
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85131835
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83951848
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83275316
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.83207403
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82100989
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80331809
64Glioma_Homo sapiens_hsa052140.80205320
65Cardiac muscle contraction_Homo sapiens_hsa042600.79504276
66MAPK signaling pathway_Homo sapiens_hsa040100.79106771
67Dorso-ventral axis formation_Homo sapiens_hsa043200.78416674
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78338873
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75290563
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74540931
71Estrogen signaling pathway_Homo sapiens_hsa049150.74207072
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.73847076
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72808958
74Oocyte meiosis_Homo sapiens_hsa041140.70851109
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70485175
76Phagosome_Homo sapiens_hsa041450.69237439
77Ras signaling pathway_Homo sapiens_hsa040140.68839425
78Vibrio cholerae infection_Homo sapiens_hsa051100.68552824
79Toxoplasmosis_Homo sapiens_hsa051450.68286424
80African trypanosomiasis_Homo sapiens_hsa051430.66674556
81Choline metabolism in cancer_Homo sapiens_hsa052310.65929630
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65218926
83Rap1 signaling pathway_Homo sapiens_hsa040150.62471194
84Dilated cardiomyopathy_Homo sapiens_hsa054140.62328057
85Chemokine signaling pathway_Homo sapiens_hsa040620.61862541
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61427687
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61280564
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60852959
89Renal cell carcinoma_Homo sapiens_hsa052110.60732660
90Pancreatic secretion_Homo sapiens_hsa049720.59361765
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58833699
92Rheumatoid arthritis_Homo sapiens_hsa053230.55058193
93Circadian rhythm_Homo sapiens_hsa047100.54609587
94Inositol phosphate metabolism_Homo sapiens_hsa005620.52593421
95Endometrial cancer_Homo sapiens_hsa052130.51858787
96Antigen processing and presentation_Homo sapiens_hsa046120.51770915
97Ovarian steroidogenesis_Homo sapiens_hsa049130.51047763
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.50206433
99Non-small cell lung cancer_Homo sapiens_hsa052230.49008003
100Bile secretion_Homo sapiens_hsa049760.48649154
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48435397
102Wnt signaling pathway_Homo sapiens_hsa043100.46246277
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.45406794
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43851536
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.43381221
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43325256
107Pancreatic cancer_Homo sapiens_hsa052120.43016919
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41931066
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41476033
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39861357
111Thyroid hormone synthesis_Homo sapiens_hsa049180.38372032
112Sphingolipid metabolism_Homo sapiens_hsa006000.35937939
113Alzheimers disease_Homo sapiens_hsa050100.31090917
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29191054
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27486197
116VEGF signaling pathway_Homo sapiens_hsa043700.26251323
117Graft-versus-host disease_Homo sapiens_hsa053320.26178394
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25843793
119Parkinsons disease_Homo sapiens_hsa050120.23597475
120Platelet activation_Homo sapiens_hsa046110.23500181
121Ether lipid metabolism_Homo sapiens_hsa005650.23127199
122Melanoma_Homo sapiens_hsa052180.22691479
123T cell receptor signaling pathway_Homo sapiens_hsa046600.22449599
124Fanconi anemia pathway_Homo sapiens_hsa034600.22157573
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21926872
126Tuberculosis_Homo sapiens_hsa051520.21329974
127Endocytosis_Homo sapiens_hsa041440.20937968
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20645146
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19701907

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