CPNE6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05098538
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.54822829
3vocalization behavior (GO:0071625)5.48959037
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39601648
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.38063606
6synaptic vesicle exocytosis (GO:0016079)5.30323300
7synaptic vesicle maturation (GO:0016188)5.25354611
8glutamate secretion (GO:0014047)5.22884399
9regulation of glutamate receptor signaling pathway (GO:1900449)5.18313074
10L-amino acid import (GO:0043092)5.15978805
11locomotory exploration behavior (GO:0035641)5.11519172
12protein localization to synapse (GO:0035418)5.07490635
13regulation of neuronal synaptic plasticity (GO:0048168)4.88036603
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.87439506
15glutamate receptor signaling pathway (GO:0007215)4.84808192
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.84765497
17neuronal action potential propagation (GO:0019227)4.78947268
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.78943735
19regulation of synaptic vesicle exocytosis (GO:2000300)4.61557345
20synaptic transmission, glutamatergic (GO:0035249)4.58076594
21cerebellar granule cell differentiation (GO:0021707)4.57765667
22amino acid import (GO:0043090)4.55014800
23exploration behavior (GO:0035640)4.54388143
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.51207489
25regulation of synaptic vesicle transport (GO:1902803)4.34624598
26neuron cell-cell adhesion (GO:0007158)4.30936802
27neurotransmitter-gated ion channel clustering (GO:0072578)4.17384170
28neuron-neuron synaptic transmission (GO:0007270)4.17152332
29regulation of voltage-gated calcium channel activity (GO:1901385)4.13723736
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.12415049
31negative regulation of dendrite morphogenesis (GO:0050774)4.12300467
32regulation of ARF protein signal transduction (GO:0032012)4.07592018
33regulation of synaptic plasticity (GO:0048167)4.06781635
34neuronal ion channel clustering (GO:0045161)4.03608467
35neurotransmitter secretion (GO:0007269)3.97385304
36long-term memory (GO:0007616)3.95929273
37positive regulation of synapse maturation (GO:0090129)3.90531804
38layer formation in cerebral cortex (GO:0021819)3.90066703
39potassium ion homeostasis (GO:0055075)3.89941561
40regulation of postsynaptic membrane potential (GO:0060078)3.86248152
41potassium ion import (GO:0010107)3.79966877
42long-term synaptic potentiation (GO:0060291)3.79513152
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77602965
44positive regulation of membrane potential (GO:0045838)3.76745395
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.76162209
46behavioral defense response (GO:0002209)3.75723564
47behavioral fear response (GO:0001662)3.75723564
48central nervous system myelination (GO:0022010)3.75679192
49axon ensheathment in central nervous system (GO:0032291)3.75679192
50proline transport (GO:0015824)3.74568711
51cellular potassium ion homeostasis (GO:0030007)3.71245295
52neuron recognition (GO:0008038)3.69054729
53innervation (GO:0060384)3.68035986
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66022433
55synaptic vesicle endocytosis (GO:0048488)3.65868205
56regulation of dendritic spine morphogenesis (GO:0061001)3.65707770
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.61675131
58regulation of synapse structural plasticity (GO:0051823)3.58891633
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54891808
60acidic amino acid transport (GO:0015800)3.53878211
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49491354
62transmission of nerve impulse (GO:0019226)3.45519601
63fear response (GO:0042596)3.44675278
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.44092384
65dendritic spine morphogenesis (GO:0060997)3.42545610
66regulation of vesicle fusion (GO:0031338)3.41957829
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.40424922
68membrane depolarization during action potential (GO:0086010)3.40286246
69cell communication by electrical coupling (GO:0010644)3.38501139
70membrane depolarization (GO:0051899)3.36147007
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.35899193
72regulation of glutamate secretion (GO:0014048)3.33901663
73dendritic spine organization (GO:0097061)3.32529748
74neurotransmitter transport (GO:0006836)3.31945493
75neurotransmitter uptake (GO:0001504)3.31294068
76neuromuscular process controlling posture (GO:0050884)3.30973612
77positive regulation of neurotransmitter secretion (GO:0001956)3.30091517
78auditory behavior (GO:0031223)3.28564538
79presynaptic membrane assembly (GO:0097105)3.28341799
80response to histamine (GO:0034776)3.27750180
81vesicle docking involved in exocytosis (GO:0006904)3.26894006
82axonal fasciculation (GO:0007413)3.26865617
83positive regulation of dendritic spine development (GO:0060999)3.24958516
84postsynaptic membrane organization (GO:0001941)3.23410020
85regulation of neurotransmitter secretion (GO:0046928)3.21791311
86neuromuscular synaptic transmission (GO:0007274)3.19816971
87regulation of synaptic transmission (GO:0050804)3.19798830
88sodium ion export (GO:0071436)3.19283487
89chemosensory behavior (GO:0007635)3.18638083
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18139211
91cerebellar Purkinje cell differentiation (GO:0021702)3.17887077
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17357830
93learning (GO:0007612)3.17168123
94establishment of synaptic vesicle localization (GO:0097480)3.15954512
95synaptic vesicle transport (GO:0048489)3.15954512
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15400832
97L-glutamate transport (GO:0015813)3.15310898
98regulation of dendritic spine development (GO:0060998)3.15187004
99gamma-aminobutyric acid transport (GO:0015812)3.13664603
100cellular sodium ion homeostasis (GO:0006883)3.13623335
101negative regulation of dendrite development (GO:2000171)3.13160004
102neuromuscular process controlling balance (GO:0050885)3.12796514
103positive regulation of fibroblast migration (GO:0010763)3.11222018
104cytoskeletal anchoring at plasma membrane (GO:0007016)3.11212358
105negative regulation of amino acid transport (GO:0051956)3.09402148
106calcium-mediated signaling using intracellular calcium source (GO:0035584)3.09379714
107positive regulation of dendrite development (GO:1900006)3.09221089
108vesicle transport along microtubule (GO:0047496)3.07487558
109activation of protein kinase A activity (GO:0034199)3.07294775
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07011641
111regulation of neurotransmitter levels (GO:0001505)3.06690490
112regulation of inositol phosphate biosynthetic process (GO:0010919)3.06208465
113* synaptic transmission (GO:0007268)3.06074336
114presynaptic membrane organization (GO:0097090)3.03624812
115regulation of exocytosis (GO:0017157)3.02886228
116long term synaptic depression (GO:0060292)3.02248814
117positive regulation of neurotransmitter transport (GO:0051590)3.01349392
118positive regulation of synaptic transmission (GO:0050806)3.00628901
119regulation of synapse maturation (GO:0090128)2.98536411
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97014405
121regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95179864
122regulation of female receptivity (GO:0045924)2.92732271
123detection of calcium ion (GO:0005513)2.92560111
124neuromuscular process (GO:0050905)2.91108420
125regulation of neurotransmitter transport (GO:0051588)2.90971497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.59736380
2GBX2_23144817_ChIP-Seq_PC3_Human4.07367863
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.29790162
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.25286557
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21095527
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84138911
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80993949
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80052269
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80052269
10REST_21632747_ChIP-Seq_MESCs_Mouse2.79010885
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67565662
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.64962647
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59726724
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55935657
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55289661
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54585653
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.46974341
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.42200931
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35368694
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.30342827
21DROSHA_22980978_ChIP-Seq_HELA_Human2.28860592
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23231276
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.21999024
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.20813938
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97715523
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91477256
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83430150
28SMAD4_21799915_ChIP-Seq_A2780_Human1.79716779
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79434537
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78412353
31TAF15_26573619_Chip-Seq_HEK293_Human1.77694181
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73483478
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70326101
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63968582
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58059913
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55886739
37P300_19829295_ChIP-Seq_ESCs_Human1.55742100
38AR_21572438_ChIP-Seq_LNCaP_Human1.52743912
39KDM2B_26808549_Chip-Seq_K562_Human1.52330682
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50430139
41ZNF274_21170338_ChIP-Seq_K562_Hela1.48141697
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47488146
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46520802
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45151926
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.44768692
46AR_25329375_ChIP-Seq_VCAP_Human1.40725062
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40106955
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35263090
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34875239
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34380770
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34066489
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.33004586
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32027241
54TET1_21490601_ChIP-Seq_MESCs_Mouse1.29672629
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.27937786
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.27607686
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26837609
58CTCF_27219007_Chip-Seq_Bcells_Human1.24934720
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24360721
60STAT3_23295773_ChIP-Seq_U87_Human1.22804659
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19974879
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.19330386
63VDR_22108803_ChIP-Seq_LS180_Human1.19141362
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19030785
65IGF1R_20145208_ChIP-Seq_DFB_Human1.18261818
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.16592348
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.16273315
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16117815
69AR_19668381_ChIP-Seq_PC3_Human1.15741174
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14135183
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13080080
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10934293
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.08518314
74TCF4_23295773_ChIP-Seq_U87_Human1.08245062
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08132805
76FUS_26573619_Chip-Seq_HEK293_Human1.08124478
77* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07793785
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06109122
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05998777
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.05818333
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.05129741
82JUN_21703547_ChIP-Seq_K562_Human1.03908467
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03901744
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03190298
85RNF2_27304074_Chip-Seq_NSC_Mouse1.02339138
86AHR_22903824_ChIP-Seq_MCF-7_Human1.00554077
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00337934
88RING1B_27294783_Chip-Seq_NPCs_Mouse0.99781066
89TP53_16413492_ChIP-PET_HCT116_Human0.99716223
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98967189
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98652534
92YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98574909
93RUNX2_22187159_ChIP-Seq_PCA_Human0.97469841
94P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97204915
95TP53_18474530_ChIP-ChIP_U2OS_Human0.97035204
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.95726672
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95216194
98OCT4_19829295_ChIP-Seq_ESCs_Human0.94991290
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94300910
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93359136
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93207245
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92817382
103* LXR_22292898_ChIP-Seq_THP-1_Human0.92766837
104DPY_21335234_ChIP-Seq_ESCs_Mouse0.92685403
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92170381
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91004631
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90315645
108KLF4_19829295_ChIP-Seq_ESCs_Human0.90259159
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.90185229
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89994709
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89485873
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89485873
113BCAT_22108803_ChIP-Seq_LS180_Human0.89342761
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88871543
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88865427
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88643540
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88543701
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.87878404
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87840630
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.87742166
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86988439
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86526558
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84977590
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84550073
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84266872
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82794699
127SMC4_20622854_ChIP-Seq_HELA_Human0.82222598
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77399051
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.75067227
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74361090
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72941559
132SMAD4_21741376_ChIP-Seq_ESCs_Human0.72525268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.34196792
2MP0003880_abnormal_central_pattern5.82747556
3MP0003635_abnormal_synaptic_transmissio4.27071197
4MP0004270_analgesia3.77207654
5MP0009745_abnormal_behavioral_response3.57291357
6MP0002063_abnormal_learning/memory/cond3.48239877
7MP0001968_abnormal_touch/_nociception3.29481380
8MP0002064_seizures3.21422526
9MP0002735_abnormal_chemical_nociception3.20565165
10MP0002736_abnormal_nociception_after2.96239244
11MP0002572_abnormal_emotion/affect_behav2.87107810
12MP0009046_muscle_twitch2.74962683
13MP0002272_abnormal_nervous_system2.67090075
14MP0001501_abnormal_sleep_pattern2.57449020
15MP0002734_abnormal_mechanical_nocicepti2.40324441
16MP0002822_catalepsy2.33451084
17MP0001486_abnormal_startle_reflex2.30373270
18MP0001440_abnormal_grooming_behavior2.24861683
19MP0004858_abnormal_nervous_system2.15066336
20MP0003329_amyloid_beta_deposits2.13308383
21MP0005423_abnormal_somatic_nervous2.07616648
22MP0006276_abnormal_autonomic_nervous2.02487384
23MP0002733_abnormal_thermal_nociception1.99354308
24MP0002067_abnormal_sensory_capabilities1.96586155
25MP0001970_abnormal_pain_threshold1.93322126
26MP0002184_abnormal_innervation1.79592601
27MP0009780_abnormal_chondrocyte_physiolo1.73913194
28MP0003879_abnormal_hair_cell1.69482909
29MP0003787_abnormal_imprinting1.69055492
30MP0004811_abnormal_neuron_physiology1.68884128
31MP0000778_abnormal_nervous_system1.66779154
32MP0008569_lethality_at_weaning1.59251865
33MP0002557_abnormal_social/conspecific_i1.54135843
34MP0000955_abnormal_spinal_cord1.48754109
35MP0005646_abnormal_pituitary_gland1.48265975
36MP0005386_behavior/neurological_phenoty1.47160084
37MP0004924_abnormal_behavior1.47160084
38MP0001905_abnormal_dopamine_level1.42768550
39MP0002909_abnormal_adrenal_gland1.41415569
40MP0002882_abnormal_neuron_morphology1.37508542
41MP0002066_abnormal_motor_capabilities/c1.35230955
42MP0001984_abnormal_olfaction1.33212162
43MP0003633_abnormal_nervous_system1.25747197
44MP0002837_dystrophic_cardiac_calcinosis1.21160273
45MP0004142_abnormal_muscle_tone1.21034912
46MP0001502_abnormal_circadian_rhythm1.19489462
47MP0004885_abnormal_endolymph1.18652249
48MP0001529_abnormal_vocalization1.17350361
49MP0000751_myopathy1.16994433
50MP0003122_maternal_imprinting1.15881592
51MP0003631_nervous_system_phenotype1.09976343
52MP0005645_abnormal_hypothalamus_physiol1.07148060
53MP0003075_altered_response_to1.04479730
54MP0001188_hyperpigmentation1.02834687
55MP0000604_amyloidosis1.02830260
56MP0005167_abnormal_blood-brain_barrier1.00802150
57MP0002876_abnormal_thyroid_physiology0.99679935
58MP0002229_neurodegeneration0.98296786
59MP0002152_abnormal_brain_morphology0.95229148
60MP0004484_altered_response_of0.91334288
61MP0001963_abnormal_hearing_physiology0.90535226
62MP0002069_abnormal_eating/drinking_beha0.89046050
63MP0008874_decreased_physiological_sensi0.86945867
64MP0004147_increased_porphyrin_level0.85626019
65MP0004145_abnormal_muscle_electrophysio0.85329097
66MP0004510_myositis0.85159298
67MP0005535_abnormal_body_temperature0.85019860
68MP0004085_abnormal_heartbeat0.83631833
69MP0008872_abnormal_physiological_respon0.83545793
70MP0001346_abnormal_lacrimal_gland0.81413692
71MP0005171_absent_coat_pigmentation0.77831563
72MP0001348_abnormal_lacrimal_gland0.77205886
73MP0003632_abnormal_nervous_system0.75351605
74MP0005551_abnormal_eye_electrophysiolog0.74058579
75MP0010386_abnormal_urinary_bladder0.73623110
76MP0001485_abnormal_pinna_reflex0.73231792
77MP0002752_abnormal_somatic_nervous0.72363759
78MP0004215_abnormal_myocardial_fiber0.71991651
79MP0001664_abnormal_digestion0.71846369
80MP0003634_abnormal_glial_cell0.71371998
81MP0003172_abnormal_lysosome_physiology0.70613058
82MP0002638_abnormal_pupillary_reflex0.70007916
83MP0001177_atelectasis0.67654523
84MP0004130_abnormal_muscle_cell0.67314614
85MP0003123_paternal_imprinting0.66961132
86MP0001765_abnormal_ion_homeostasis0.66713035
87MP0004742_abnormal_vestibular_system0.66063912
88MP0003183_abnormal_peptide_metabolism0.62987456
89MP0005166_decreased_susceptibility_to0.58771349
90MP0000920_abnormal_myelination0.57283089
91MP0003690_abnormal_glial_cell0.56661089
92MP0005499_abnormal_olfactory_system0.53961009
93MP0005394_taste/olfaction_phenotype0.53961009
94MP0001986_abnormal_taste_sensitivity0.53778915
95MP0000026_abnormal_inner_ear0.53541863
96MP0008877_abnormal_DNA_methylation0.51857787
97MP0006292_abnormal_olfactory_placode0.51578866
98MP0003137_abnormal_impulse_conducting0.51482402
99MP0000013_abnormal_adipose_tissue0.51273249
100MP0010234_abnormal_vibrissa_follicle0.50506613
101MP0010768_mortality/aging0.49704968
102MP0005409_darkened_coat_color0.49559876
103MP0005595_abnormal_vascular_smooth0.48206232
104MP0002082_postnatal_lethality0.47676104
105MP0010770_preweaning_lethality0.47676104
106MP0003121_genomic_imprinting0.46378694
107MP0004233_abnormal_muscle_weight0.45532558
108MP0005623_abnormal_meninges_morphology0.45160383
109MP0003283_abnormal_digestive_organ0.44921462
110MP0003956_abnormal_body_size0.44887957
111MP0001943_abnormal_respiration0.44874953
112MP0010769_abnormal_survival0.44071698
113MP0002090_abnormal_vision0.43734296
114MP0003861_abnormal_nervous_system0.42058783
115MP0002873_normal_phenotype0.41536186
116MP0002169_no_abnormal_phenotype0.40021183
117MP0000569_abnormal_digit_pigmentation0.39931499
118MP0002089_abnormal_postnatal_growth/wei0.39840486

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.79616990
2Myokymia (HP:0002411)7.56198748
3Focal seizures (HP:0007359)6.07538997
4Atonic seizures (HP:0010819)5.43162678
5Visual hallucinations (HP:0002367)5.35554875
6Epileptic encephalopathy (HP:0200134)5.32383213
7Febrile seizures (HP:0002373)5.08610352
8Absence seizures (HP:0002121)4.57846863
9Progressive cerebellar ataxia (HP:0002073)4.45839084
10Dialeptic seizures (HP:0011146)4.37795245
11Generalized tonic-clonic seizures (HP:0002069)4.08913438
12Action tremor (HP:0002345)3.95048775
13Hyperventilation (HP:0002883)3.84293212
14Supranuclear gaze palsy (HP:0000605)3.80261137
15Amblyopia (HP:0000646)3.74079801
16Abnormality of the lower motor neuron (HP:0002366)3.59594609
17Impaired vibration sensation in the lower limbs (HP:0002166)3.51615500
18Limb dystonia (HP:0002451)3.30782989
19Dysmetria (HP:0001310)3.30253871
20Neuronal loss in central nervous system (HP:0002529)3.30009633
21Gaze-evoked nystagmus (HP:0000640)3.26593815
22Tetraplegia (HP:0002445)3.25712055
23Cerebral hypomyelination (HP:0006808)3.25528332
24Obstructive sleep apnea (HP:0002870)3.23646991
25Broad-based gait (HP:0002136)3.18769605
26Truncal ataxia (HP:0002078)3.14201566
27Depression (HP:0000716)3.07795010
28Anxiety (HP:0000739)3.03892467
29Cerebral inclusion bodies (HP:0100314)2.98374171
30Dysdiadochokinesis (HP:0002075)2.93381364
31Akinesia (HP:0002304)2.87796068
32Poor eye contact (HP:0000817)2.86688753
33Abnormal eating behavior (HP:0100738)2.81993592
34Epileptiform EEG discharges (HP:0011182)2.75783888
35Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.72089559
36Postural instability (HP:0002172)2.71025799
37Urinary bladder sphincter dysfunction (HP:0002839)2.70515508
38Delusions (HP:0000746)2.67894819
39Clonus (HP:0002169)2.67875591
40Abnormal social behavior (HP:0012433)2.67078520
41Impaired social interactions (HP:0000735)2.67078520
42Excessive salivation (HP:0003781)2.62644052
43Drooling (HP:0002307)2.62644052
44Diminished motivation (HP:0000745)2.60646738
45Ankle clonus (HP:0011448)2.59441671
46Diplopia (HP:0000651)2.56162011
47Abnormality of binocular vision (HP:0011514)2.56162011
48Spastic tetraparesis (HP:0001285)2.56041916
49Impaired smooth pursuit (HP:0007772)2.55732248
50Termporal pattern (HP:0011008)2.55531454
51Insidious onset (HP:0003587)2.55531454
52Scanning speech (HP:0002168)2.54033223
53Peripheral hypomyelination (HP:0007182)2.52655573
54Bradykinesia (HP:0002067)2.52212593
55Neurofibrillary tangles (HP:0002185)2.49539034
56Decreased circulating renin level (HP:0003351)2.48688243
57Hemiparesis (HP:0001269)2.48355406
58Urinary urgency (HP:0000012)2.46258485
59Ulnar claw (HP:0001178)2.39782340
60EEG with generalized epileptiform discharges (HP:0011198)2.38665900
61Progressive inability to walk (HP:0002505)2.36290730
62Impaired vibratory sensation (HP:0002495)2.35019187
63Genetic anticipation (HP:0003743)2.33603523
64Increased circulating renin level (HP:0000848)2.32575982
65Pheochromocytoma (HP:0002666)2.31577436
66Sleep apnea (HP:0010535)2.30742737
67Stereotypic behavior (HP:0000733)2.30227291
68Spastic gait (HP:0002064)2.29830598
69Absent speech (HP:0001344)2.28963417
70Fetal akinesia sequence (HP:0001989)2.28702872
71Ventricular fibrillation (HP:0001663)2.28477360
72Hypsarrhythmia (HP:0002521)2.21512885
73Generalized myoclonic seizures (HP:0002123)2.18904448
74Inability to walk (HP:0002540)2.17691820
75Insomnia (HP:0100785)2.17437486
76Mutism (HP:0002300)2.16849369
77Annular pancreas (HP:0001734)2.16626548
78Abnormality of ocular smooth pursuit (HP:0000617)2.16480280
79Focal dystonia (HP:0004373)2.14428443
80Incomplete penetrance (HP:0003829)2.14365315
81Abnormality of saccadic eye movements (HP:0000570)2.12969468
82Rapidly progressive (HP:0003678)2.10522422
83Choreoathetosis (HP:0001266)2.08668850
84Status epilepticus (HP:0002133)2.07805228
85Lower limb muscle weakness (HP:0007340)2.05577690
86Torticollis (HP:0000473)2.05566283
87Hemiplegia (HP:0002301)2.05232372
88Neuroendocrine neoplasm (HP:0100634)2.04400867
89Slow saccadic eye movements (HP:0000514)2.03339473
90Megalencephaly (HP:0001355)2.00768168
91Psychosis (HP:0000709)1.99991052
92CNS hypomyelination (HP:0003429)1.96475340
93Memory impairment (HP:0002354)1.95138039
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94771940
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.94771940
96Gait ataxia (HP:0002066)1.94312665
97Retinal dysplasia (HP:0007973)1.93489032
98Intention tremor (HP:0002080)1.93353288
99Morphological abnormality of the pyramidal tract (HP:0002062)1.92102096
100Dementia (HP:0000726)1.91733868
101Dysmetric saccades (HP:0000641)1.90054285
102Blue irides (HP:0000635)1.88733383
103Anosmia (HP:0000458)1.88291424
104Lower limb asymmetry (HP:0100559)1.87998468
105Amyotrophic lateral sclerosis (HP:0007354)1.87103354
106Lower limb amyotrophy (HP:0007210)1.86763833
107Abnormality of the corticospinal tract (HP:0002492)1.84590479
108Hammertoe (HP:0001765)1.82383932
109Spinal canal stenosis (HP:0003416)1.81857043
110Split foot (HP:0001839)1.81185295
111Abnormality of salivation (HP:0100755)1.80185260
112Protruding tongue (HP:0010808)1.78400601
113Syncope (HP:0001279)1.78315035
114Thickened helices (HP:0000391)1.77580977
115Unsteady gait (HP:0002317)1.77384108
116Hyperactive renin-angiotensin system (HP:0000841)1.76933437
117Limb ataxia (HP:0002070)1.76756930
118Craniofacial dystonia (HP:0012179)1.76296480
119Rigidity (HP:0002063)1.75193339
120Type II lissencephaly (HP:0007260)1.72883729
121Abnormality of the periventricular white matter (HP:0002518)1.71920176
122Polyphagia (HP:0002591)1.68860908
123Pointed chin (HP:0000307)1.68472868
124Apathy (HP:0000741)1.66265021
125Papilledema (HP:0001085)1.65978440
126Hypoventilation (HP:0002791)1.65824888
127Global brain atrophy (HP:0002283)1.65454972
128Impaired pain sensation (HP:0007328)1.64920494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.96992860
2EPHA45.01539911
3MAP3K93.65455953
4MINK12.89351857
5MAP3K42.70122599
6MAP3K122.68495255
7KSR22.49798064
8MAP2K72.40320959
9CASK2.31144876
10RIPK42.28098454
11ARAF2.13068248
12DAPK21.97936093
13PLK21.96559692
14KSR11.89044802
15MAP2K41.84716695
16DAPK11.80320295
17MAP3K131.77359771
18PRPF4B1.75144294
19PAK61.75029414
20PTK2B1.74721174
21GRK51.69412555
22PRKD31.63767135
23TNIK1.52326485
24FES1.50297702
25NTRK11.43678012
26CDK51.43122871
27NME11.41027197
28MARK11.40421315
29NTRK21.37286851
30PNCK1.36139893
31PRKCG1.35679270
32CAMKK11.24012288
33RIPK11.23099917
34MAP3K21.23002393
35STK381.19082149
36CAMK2A1.19033915
37CAMK2B1.13971888
38RAF11.13526803
39MAPK131.12113799
40LMTK21.10713119
41CDK191.09817326
42SIK21.00682073
43SIK30.99270302
44BMPR20.98116506
45CAMK10.94397650
46ALK0.92975004
47MAPK120.92730327
48FGR0.92070188
49FER0.91618384
50LATS20.86244806
51CCNB10.82630566
52SGK2230.77712135
53SGK4940.77712135
54CDK180.77686656
55PKN10.75806143
56MAP3K10.75328301
57BRSK10.73311441
58CDK150.71423686
59CDK140.71079973
60MAP3K110.69250913
61DAPK30.69086480
62SGK20.68042475
63BRAF0.67655179
64SGK10.63910539
65PINK10.63518011
66PDK10.62426561
67MAP3K70.61738176
68PRKCH0.61397851
69TNK20.61250105
70CDK11A0.61101093
71DYRK1A0.60840285
72UHMK10.60177414
73TYRO30.59850592
74MARK20.59780633
75OXSR10.59540755
76MAP2K10.59478141
77PAK30.59227339
78CAMK2D0.59162895
79PDPK10.57617548
80PHKG20.57401690
81PHKG10.57401690
82PRKCE0.55957755
83RET0.55946554
84GRK70.55854756
85AKT30.54855313
86CAMK2G0.53775736
87TESK10.52829821
88LIMK10.52064121
89GRK60.50593906
90STK110.49910022
91FGFR20.48800866
92MOS0.48479143
93CAMKK20.47483426
94SGK30.46845072
95TAOK10.43748610
96CAMK1G0.42041684
97CSNK1G20.41440617
98BCR0.40779627
99MUSK0.40704031
100CAMK1D0.39878620
101RPS6KA30.39623954
102CDC42BPA0.37776864
103MAP2K60.36789229
104MAPK100.36454179
105PRKCZ0.34900871
106PRKG20.33994541
107FYN0.33873224
108PRKCA0.33665489
109ROCK20.32823271
110MAPK80.31674884
111ROCK10.31277117
112WNK10.31020177
113CAMK40.30959167
114PRKACA0.30451543
115IRAK20.30416713
116NEK60.28105785
117PRKCB0.28073836
118ADRBK10.27470114
119ERBB20.27294553
120CSNK1E0.26670699
121CSNK1D0.25612459
122PRKG10.25364999

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15700395
2Synaptic vesicle cycle_Homo sapiens_hsa047213.33529609
3Long-term potentiation_Homo sapiens_hsa047203.12337456
4Circadian entrainment_Homo sapiens_hsa047132.91618954
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81918410
6Olfactory transduction_Homo sapiens_hsa047402.79620207
7Amphetamine addiction_Homo sapiens_hsa050312.72785012
8Glutamatergic synapse_Homo sapiens_hsa047242.65213735
9GABAergic synapse_Homo sapiens_hsa047272.50096108
10Morphine addiction_Homo sapiens_hsa050322.35312842
11Salivary secretion_Homo sapiens_hsa049702.30215113
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26615959
13Dopaminergic synapse_Homo sapiens_hsa047282.15707030
14Collecting duct acid secretion_Homo sapiens_hsa049662.00577183
15Insulin secretion_Homo sapiens_hsa049111.96729603
16Taste transduction_Homo sapiens_hsa047421.95866096
17Gastric acid secretion_Homo sapiens_hsa049711.90511576
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86364800
19Calcium signaling pathway_Homo sapiens_hsa040201.83806705
20Cholinergic synapse_Homo sapiens_hsa047251.78983770
21Oxytocin signaling pathway_Homo sapiens_hsa049211.72612211
22Vitamin B6 metabolism_Homo sapiens_hsa007501.70620585
23Long-term depression_Homo sapiens_hsa047301.69583421
24Renin secretion_Homo sapiens_hsa049241.69104231
25Serotonergic synapse_Homo sapiens_hsa047261.65995101
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60195409
27GnRH signaling pathway_Homo sapiens_hsa049121.54986161
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52987009
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51323496
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.33665924
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33437616
32Cocaine addiction_Homo sapiens_hsa050301.32520087
33cAMP signaling pathway_Homo sapiens_hsa040241.30706687
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22050052
35Vibrio cholerae infection_Homo sapiens_hsa051101.20204454
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19067858
37Gap junction_Homo sapiens_hsa045401.17299290
38Glioma_Homo sapiens_hsa052141.16165041
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15740354
40Cardiac muscle contraction_Homo sapiens_hsa042601.13876213
41Estrogen signaling pathway_Homo sapiens_hsa049151.03768746
42Melanogenesis_Homo sapiens_hsa049161.03764415
43Axon guidance_Homo sapiens_hsa043601.02928997
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02279941
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01898191
46Type II diabetes mellitus_Homo sapiens_hsa049300.97223901
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.96257994
48ErbB signaling pathway_Homo sapiens_hsa040120.93958571
49Alzheimers disease_Homo sapiens_hsa050100.90401741
50Oocyte meiosis_Homo sapiens_hsa041140.90288032
51Phototransduction_Homo sapiens_hsa047440.89012544
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88133913
53Oxidative phosphorylation_Homo sapiens_hsa001900.86026054
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85353247
55Pancreatic secretion_Homo sapiens_hsa049720.83482502
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82666743
57Dorso-ventral axis formation_Homo sapiens_hsa043200.79362008
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.75382056
59Choline metabolism in cancer_Homo sapiens_hsa052310.74695191
60Glucagon signaling pathway_Homo sapiens_hsa049220.70904458
61Thyroid hormone synthesis_Homo sapiens_hsa049180.70581576
62VEGF signaling pathway_Homo sapiens_hsa043700.68133258
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67160673
64MAPK signaling pathway_Homo sapiens_hsa040100.63344010
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59576951
66Dilated cardiomyopathy_Homo sapiens_hsa054140.59574515
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.56531018
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55167342
69Ras signaling pathway_Homo sapiens_hsa040140.55129734
70Rap1 signaling pathway_Homo sapiens_hsa040150.51262335
71Inositol phosphate metabolism_Homo sapiens_hsa005620.50329009
72African trypanosomiasis_Homo sapiens_hsa051430.49838878
73Prion diseases_Homo sapiens_hsa050200.47766089
74Parkinsons disease_Homo sapiens_hsa050120.47701440
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47430552
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46292485
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46111052
78Bile secretion_Homo sapiens_hsa049760.40651097
79Huntingtons disease_Homo sapiens_hsa050160.40009885
80Rheumatoid arthritis_Homo sapiens_hsa053230.38855187
81Type I diabetes mellitus_Homo sapiens_hsa049400.38346823
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38288778
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.35962857
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35570405
85Circadian rhythm_Homo sapiens_hsa047100.35156169
86Endocytosis_Homo sapiens_hsa041440.35097881
87Arginine and proline metabolism_Homo sapiens_hsa003300.34281876
88Wnt signaling pathway_Homo sapiens_hsa043100.31938968
89Arginine biosynthesis_Homo sapiens_hsa002200.31749623
90Fatty acid biosynthesis_Homo sapiens_hsa000610.30988122
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30456661
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29529199
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28159780
94Insulin signaling pathway_Homo sapiens_hsa049100.28143728
95Alcoholism_Homo sapiens_hsa050340.28038014
96Nitrogen metabolism_Homo sapiens_hsa009100.27758851
97Histidine metabolism_Homo sapiens_hsa003400.27070199
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26893538
99Non-small cell lung cancer_Homo sapiens_hsa052230.24861020
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24276998
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24244974
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24136930
103mTOR signaling pathway_Homo sapiens_hsa041500.23563229
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22424395
105Ovarian steroidogenesis_Homo sapiens_hsa049130.22108405
106Tight junction_Homo sapiens_hsa045300.21772112
107Mineral absorption_Homo sapiens_hsa049780.21442559
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21409151
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20776204
110HIF-1 signaling pathway_Homo sapiens_hsa040660.20207546
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19083424
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19027353
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.18374114
114AMPK signaling pathway_Homo sapiens_hsa041520.15618382

Most similar genes based on co-expression Upload to Enrichr

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