CPNE7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.47429236
2vocalization behavior (GO:0071625)6.05673550
3regulation of translational fidelity (GO:0006450)5.85219673
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.83807192
5COPI coating of Golgi vesicle (GO:0048205)5.80951028
6Golgi transport vesicle coating (GO:0048200)5.80951028
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.79601354
8synaptic vesicle exocytosis (GO:0016079)5.59743338
9locomotory exploration behavior (GO:0035641)5.50583709
10synaptic vesicle maturation (GO:0016188)5.49679901
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.46095792
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.44427020
13proline biosynthetic process (GO:0006561)5.29935925
14neuron cell-cell adhesion (GO:0007158)5.22728866
15glutamate secretion (GO:0014047)5.19782418
16regulation of glutamate receptor signaling pathway (GO:1900449)5.07970259
17protein localization to synapse (GO:0035418)5.06262720
18glutamate receptor signaling pathway (GO:0007215)5.04301718
19activation of Rac GTPase activity (GO:0032863)5.01815819
20DNA unwinding involved in DNA replication (GO:0006268)4.93662418
21exploration behavior (GO:0035640)4.93257311
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.88445133
23regulation of neuronal synaptic plasticity (GO:0048168)4.82596382
24nuclear pore complex assembly (GO:0051292)4.82385639
25synaptic transmission, glutamatergic (GO:0035249)4.72446534
26regulation of synaptic vesicle exocytosis (GO:2000300)4.59511455
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47244076
28neuron-neuron synaptic transmission (GO:0007270)4.43897204
29mitotic chromosome condensation (GO:0007076)4.42202152
30neurotransmitter secretion (GO:0007269)4.41236941
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.39433922
32regulation of synaptic vesicle transport (GO:1902803)4.25890615
33long-term memory (GO:0007616)4.25275458
34synaptic vesicle endocytosis (GO:0048488)4.23555233
35synaptic vesicle docking involved in exocytosis (GO:0016081)4.23452914
36regulation of translational termination (GO:0006449)4.23285879
37dendritic spine morphogenesis (GO:0060997)4.18311783
38regulation of synapse structural plasticity (GO:0051823)4.17881617
39protein retention in ER lumen (GO:0006621)4.14097596
40regulation of excitatory postsynaptic membrane potential (GO:0060079)4.11366341
41neuron recognition (GO:0008038)4.03708143
42gamma-aminobutyric acid signaling pathway (GO:0007214)4.03248410
43neuronal action potential propagation (GO:0019227)3.99588216
44proline transport (GO:0015824)3.95458091
45regulation of postsynaptic membrane potential (GO:0060078)3.94243040
46positive regulation of membrane potential (GO:0045838)3.93062318
47neurotransmitter transport (GO:0006836)3.84324545
48cellular potassium ion homeostasis (GO:0030007)3.83397070
49nuclear pore organization (GO:0006999)3.82860626
50regulation of synaptic plasticity (GO:0048167)3.80990329
51neurotransmitter-gated ion channel clustering (GO:0072578)3.79406035
52proline metabolic process (GO:0006560)3.78890299
53response to histamine (GO:0034776)3.77767604
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74405566
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.73495129
56regulation of vesicle fusion (GO:0031338)3.71852237
57regulation of mitotic spindle organization (GO:0060236)3.71581172
58long-term synaptic potentiation (GO:0060291)3.70086721
59positive regulation of synapse maturation (GO:0090129)3.68305706
60mitotic sister chromatid segregation (GO:0000070)3.67736405
61layer formation in cerebral cortex (GO:0021819)3.67177689
62regulation of dendritic spine morphogenesis (GO:0061001)3.65650200
63gamma-aminobutyric acid transport (GO:0015812)3.64453848
64behavioral defense response (GO:0002209)3.63801265
65behavioral fear response (GO:0001662)3.63801265
66regulation of neurotransmitter levels (GO:0001505)3.62226077
67innervation (GO:0060384)3.60295712
68positive regulation of dendritic spine development (GO:0060999)3.60101286
69transmission of nerve impulse (GO:0019226)3.56176960
70folic acid metabolic process (GO:0046655)3.54879475
71pore complex assembly (GO:0046931)3.53894730
72dendritic spine organization (GO:0097061)3.52538953
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.51722897
74axonal fasciculation (GO:0007413)3.50573795
75nucleobase-containing small molecule interconversion (GO:0015949)3.50418664
76spliceosomal tri-snRNP complex assembly (GO:0000244)3.48372331
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.45939970
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45353948
79folic acid-containing compound biosynthetic process (GO:0009396)3.44490226
80DNA replication initiation (GO:0006270)3.44296740
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44227762
82sodium ion export (GO:0071436)3.42441609
83postsynaptic membrane organization (GO:0001941)3.40086158
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39091836
85desmosome organization (GO:0002934)3.39078642
86fear response (GO:0042596)3.38304071
87mating behavior (GO:0007617)3.37777705
88positive regulation of neurotransmitter secretion (GO:0001956)3.37692184
89focal adhesion assembly (GO:0048041)3.37082939
90cell-substrate adherens junction assembly (GO:0007045)3.37082939
91negative regulation of cell size (GO:0045792)3.36335705
92DNA strand elongation involved in DNA replication (GO:0006271)3.34599630
93negative regulation of DNA-templated transcription, elongation (GO:0032785)3.34243824
94regulation of synaptic transmission, glutamatergic (GO:0051966)3.33155054
95behavioral response to cocaine (GO:0048148)3.33049626
96DNA duplex unwinding (GO:0032508)3.31023712
97DNA strand elongation (GO:0022616)3.30986983
98intraspecies interaction between organisms (GO:0051703)3.29761772
99social behavior (GO:0035176)3.29761772
100nuclear envelope reassembly (GO:0031468)3.29400714
101mitotic nuclear envelope reassembly (GO:0007084)3.29400714
102membrane depolarization (GO:0051899)3.29214593
103positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28902762
104neuromuscular process controlling posture (GO:0050884)3.28286582
105chemosensory behavior (GO:0007635)3.28036158
106learning (GO:0007612)3.27368860
107adherens junction assembly (GO:0034333)3.27270092
108positive regulation of neurotransmitter transport (GO:0051590)3.25778729
109regulation of dendritic spine development (GO:0060998)3.24711177
110regulation of neurotransmitter secretion (GO:0046928)3.22857010
111DNA topological change (GO:0006265)3.22611616
112snRNA metabolic process (GO:0016073)3.22298735
113G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22171037
114mitotic G1 DNA damage checkpoint (GO:0031571)3.20301477
115regulation of histone H3-K27 methylation (GO:0061085)3.20103642
116cell-substrate junction assembly (GO:0007044)3.19958816
117regulation of RNA export from nucleus (GO:0046831)3.19896942
118positive regulation of DNA-dependent DNA replication (GO:2000105)3.19120423
119cell communication by electrical coupling (GO:0010644)3.18071266
120establishment of synaptic vesicle localization (GO:0097480)3.17387870
121synaptic vesicle transport (GO:0048489)3.17387870
122regulation of translational elongation (GO:0006448)3.16908400
123sister chromatid segregation (GO:0000819)3.16828532
124formation of translation preinitiation complex (GO:0001731)3.15949821
125presynaptic membrane assembly (GO:0097105)3.14180918
126stress granule assembly (GO:0034063)3.11485103
127DNA geometric change (GO:0032392)3.10855225
128hemidesmosome assembly (GO:0031581)3.10633336
129telomere maintenance via semi-conservative replication (GO:0032201)3.10027417
130regulation of catecholamine metabolic process (GO:0042069)3.09233565
131regulation of dopamine metabolic process (GO:0042053)3.09233565
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08992681
133peptidyl-arginine omega-N-methylation (GO:0035247)3.08265693
134regulation of synaptic transmission (GO:0050804)3.08068918
135synaptic transmission (GO:0007268)3.07327379
136positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06986749
137regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06248388
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06219913
139positive regulation of synaptic transmission (GO:0050806)3.05413690
140synapse assembly (GO:0007416)3.03977557
141regulation of glutamate secretion (GO:0014048)3.03255313
142startle response (GO:0001964)3.02435115
143glucocorticoid receptor signaling pathway (GO:0042921)3.01647372
144membrane depolarization during action potential (GO:0086010)3.00723321
145snRNA processing (GO:0016180)3.00300233
146ribosome biogenesis (GO:0042254)3.00035948
147apoptotic process involved in morphogenesis (GO:0060561)2.99986243
148cerebellar Purkinje cell differentiation (GO:0021702)2.99517058
149mitotic nuclear envelope disassembly (GO:0007077)2.99496643
150regulation of neurotransmitter transport (GO:0051588)2.99375804
151chromosome condensation (GO:0030261)2.99299727
152protein export from nucleus (GO:0006611)2.98684457
153regulation of nucleobase-containing compound transport (GO:0032239)2.98478685
154membrane hyperpolarization (GO:0060081)2.98082602
155dopamine biosynthetic process (GO:0042416)2.96001951
156vesicle transport along microtubule (GO:0047496)2.93871346
157negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93685313
158regulation of mammary gland epithelial cell proliferation (GO:0033599)2.90418794
159G1 DNA damage checkpoint (GO:0044783)2.89393381
160regulation of early endosome to late endosome transport (GO:2000641)2.89179391
161mitotic G1/S transition checkpoint (GO:0044819)2.89157678
162DNA conformation change (GO:0071103)2.85171888
163nuclear envelope disassembly (GO:0051081)2.83318229
164membrane disassembly (GO:0030397)2.83318229
165ncRNA 3-end processing (GO:0043628)2.81731314
166establishment of apical/basal cell polarity (GO:0035089)2.81611704
167nuclear envelope organization (GO:0006998)2.80828695
168mitochondrial DNA metabolic process (GO:0032042)2.78913766
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76903520
170endoplasmic reticulum unfolded protein response (GO:0030968)2.75546503
171activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72409565
172semaphorin-plexin signaling pathway (GO:0071526)2.69520620
173positive regulation of nuclease activity (GO:0032075)2.68817883
174tRNA aminoacylation for protein translation (GO:0006418)2.65375192
175tRNA methylation (GO:0030488)2.65277079
176UV protection (GO:0009650)2.64748935
177heterochromatin organization (GO:0070828)2.64304650
178maternal placenta development (GO:0001893)2.60504971
179negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.60355929
180regulation of spindle organization (GO:0090224)2.59459590
181ER-nucleus signaling pathway (GO:0006984)2.58357818
182protein hydroxylation (GO:0018126)2.57472025
183protein localization to chromosome, centromeric region (GO:0071459)2.57097751
184ribosome assembly (GO:0042255)2.56479105
185cytoskeletal anchoring at plasma membrane (GO:0007016)2.56410911
186GDP-mannose metabolic process (GO:0019673)2.56087317
187regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55974725
188cellular response to unfolded protein (GO:0034620)2.55146485
189folic acid-containing compound metabolic process (GO:0006760)2.55120615
190mammary gland epithelial cell proliferation (GO:0033598)2.53183138
191telomere maintenance via recombination (GO:0000722)2.51983061
192histone phosphorylation (GO:0016572)2.50218243
193glutamine family amino acid biosynthetic process (GO:0009084)2.50070304
194regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48837490
195mesodermal cell differentiation (GO:0048333)2.47837368
196regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47112298
197ribonucleoprotein complex biogenesis (GO:0022613)2.47110592
198amino acid activation (GO:0043038)2.44933501
199tRNA aminoacylation (GO:0043039)2.44933501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.49328303
2E2F7_22180533_ChIP-Seq_HELA_Human5.11193791
3GBX2_23144817_ChIP-Seq_PC3_Human3.76456419
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.75450524
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21624068
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17531842
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12022241
8ZNF263_19887448_ChIP-Seq_K562_Human2.98780341
9MYC_22102868_ChIP-Seq_BL_Human2.88945545
10REST_21632747_ChIP-Seq_MESCs_Mouse2.83661327
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.83010951
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.76182410
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70129216
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70129216
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68402392
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67803291
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65854979
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58709969
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53311894
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.52780730
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52280324
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50975877
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.44825609
24* EZH2_27304074_Chip-Seq_ESCs_Mouse2.42706490
25DROSHA_22980978_ChIP-Seq_HELA_Human2.42553159
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.39883750
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.31764058
28* EED_16625203_ChIP-ChIP_MESCs_Mouse2.31132030
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.27551576
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25517788
31LXR_22292898_ChIP-Seq_THP-1_Human2.24593364
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.24302033
33* REST_18959480_ChIP-ChIP_MESCs_Mouse2.22993700
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22959260
35* ELK3_25401928_ChIP-Seq_HUVEC_Human2.21823703
36RNF2_27304074_Chip-Seq_ESCs_Mouse2.18672041
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16978704
38VDR_21846776_ChIP-Seq_THP-1_Human2.04484916
39MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02795973
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00199508
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.98226708
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96840346
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95899591
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95256151
45RACK7_27058665_Chip-Seq_MCF-7_Human1.93514225
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92400935
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91233539
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88763500
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86984473
50TAF15_26573619_Chip-Seq_HEK293_Human1.86390987
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82656040
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82646751
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77331884
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75376909
55SMAD4_21799915_ChIP-Seq_A2780_Human1.73127026
56ZNF274_21170338_ChIP-Seq_K562_Hela1.67819772
57XRN2_22483619_ChIP-Seq_HELA_Human1.67371284
58AR_21572438_ChIP-Seq_LNCaP_Human1.67035636
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66139596
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65344818
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59997812
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59753529
63DCP1A_22483619_ChIP-Seq_HELA_Human1.58387691
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57173110
65ATF3_27146783_Chip-Seq_COLON_Human1.57160829
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56900196
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56553372
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55579224
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.54053920
70P68_20966046_ChIP-Seq_HELA_Human1.53152861
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52775365
72TCF7_22412390_ChIP-Seq_EML_Mouse1.52634253
73P300_19829295_ChIP-Seq_ESCs_Human1.51919617
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.50207737
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50058347
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49547541
77IGF1R_20145208_ChIP-Seq_DFB_Human1.48743987
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48471902
79NCOR1_26117541_ChIP-Seq_K562_Human1.48364675
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48333670
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47724149
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47696314
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47613894
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46533156
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46338672
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.43146630
87KDM2B_26808549_Chip-Seq_DND41_Human1.43038001
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43006768
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42703149
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42363927
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41362708
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40908788
93TP53_22127205_ChIP-Seq_IMR90_Human1.38161899
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38157550
95* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38129812
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37137124
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35687572
98AR_21909140_ChIP-Seq_LNCAP_Human1.34056672
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.32551704
100AR_25329375_ChIP-Seq_VCAP_Human1.32433695
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32380503
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.32094046
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.31937074
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.31640303
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31434827
106* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30899653
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30151527
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29107398
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28936571
110* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28067589
111KDM2B_26808549_Chip-Seq_K562_Human1.26693691
112CLOCK_20551151_ChIP-Seq_293T_Human1.26527950
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.26033695
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24997578
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24962569
116VDR_22108803_ChIP-Seq_LS180_Human1.24705355
117CREB1_26743006_Chip-Seq_LNCaP_Human1.23729650
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23283290
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22698464
120* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22297810
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21926032
122TP53_16413492_ChIP-PET_HCT116_Human1.19025863
123FUS_26573619_Chip-Seq_HEK293_Human1.18955892
124STAT3_23295773_ChIP-Seq_U87_Human1.18642407
125KDM5A_27292631_Chip-Seq_BREAST_Human1.18312861
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17013574
127AR_19668381_ChIP-Seq_PC3_Human1.16450673
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.15355934
129ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15266621
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14142640
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13999959
132POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13834829
133MAF_26560356_Chip-Seq_TH2_Human1.12412051
134E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12161298
135SMC4_20622854_ChIP-Seq_HELA_Human1.11964757
136HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11475142
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.11239671
138* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11201705
139ELF1_20517297_ChIP-Seq_JURKAT_Human1.10943384
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10567746
141NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10549271
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09819132
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09646704
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09645408
145PRDM14_20953172_ChIP-Seq_ESCs_Human1.09155963
146DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09115092
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08516734
148CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08456212
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08034525
150MAF_26560356_Chip-Seq_TH1_Human1.07952414
151TCF4_23295773_ChIP-Seq_U87_Human1.07631398
152TTF2_22483619_ChIP-Seq_HELA_Human1.06924967
153KDM2B_26808549_Chip-Seq_JURKAT_Human1.06285182
154ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05968060
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05349081
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03965365
157E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03078152
158* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03037048
159GABP_19822575_ChIP-Seq_HepG2_Human1.02129214
160RING1B_27294783_Chip-Seq_NPCs_Mouse1.01808026
161TP53_18474530_ChIP-ChIP_U2OS_Human1.01538150
162NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00961536
163TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00493980
164* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00146375
165* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99697874
166CHD1_26751641_Chip-Seq_LNCaP_Human0.99676084
167CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99525966
168RNF2_27304074_Chip-Seq_NSC_Mouse0.99468780
169SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98205534
170PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98166774
171JUN_21703547_ChIP-Seq_K562_Human0.97672224
172TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97242466
173CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96640786
174RARA_24833708_ChIP-Seq_LIVER_Mouse0.96501181
175RUNX2_22187159_ChIP-Seq_PCA_Human0.96471549
176P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95385752
177NANOG_18555785_Chip-Seq_ESCs_Mouse0.95264737
178* UBF1/2_26484160_Chip-Seq_HMECs_Human0.94813393
179ARNT_22903824_ChIP-Seq_MCF-7_Human0.94440042
180FOXP1_21924763_ChIP-Seq_HESCs_Human0.94343569
181* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94080254
182AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93465235
183RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93161753
184BCAT_22108803_ChIP-Seq_LS180_Human0.92908988
185ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91296891
186SMAD3_21741376_ChIP-Seq_ESCs_Human0.89739747
187TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88549491
188* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87657443
189SMAD3_21741376_ChIP-Seq_HESCs_Human0.87618352
190AHR_22903824_ChIP-Seq_MCF-7_Human0.87044799
191SMAD4_21741376_ChIP-Seq_HESCs_Human0.86791675
192POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86761887
193TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86761887
194ER_23166858_ChIP-Seq_MCF-7_Human0.85995913
195WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84161850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.09224815
2MP0003880_abnormal_central_pattern5.64071811
3MP0003705_abnormal_hypodermis_morpholog5.28638429
4MP0003635_abnormal_synaptic_transmissio4.31833802
5MP0009745_abnormal_behavioral_response3.59948694
6MP0002877_abnormal_melanocyte_morpholog3.50590088
7MP0002063_abnormal_learning/memory/cond3.47228485
8MP0002064_seizures3.31019467
9MP0003111_abnormal_nucleus_morphology3.29598057
10MP0004270_analgesia3.14746748
11MP0001348_abnormal_lacrimal_gland3.05308025
12MP0001968_abnormal_touch/_nociception2.94730860
13MP0002572_abnormal_emotion/affect_behav2.93968095
14MP0008438_abnormal_cutaneous_collagen2.92143137
15MP0001501_abnormal_sleep_pattern2.89759810
16MP0010094_abnormal_chromosome_stability2.88723551
17MP0009046_muscle_twitch2.84909367
18MP0005451_abnormal_body_composition2.84000916
19MP0005076_abnormal_cell_differentiation2.82771505
20MP0002272_abnormal_nervous_system2.66960417
21MP0005423_abnormal_somatic_nervous2.63861085
22MP0010234_abnormal_vibrissa_follicle2.57370650
23MP0001486_abnormal_startle_reflex2.48633077
24MP0002736_abnormal_nociception_after2.43174962
25MP0002735_abnormal_chemical_nociception2.34593148
26MP0006276_abnormal_autonomic_nervous2.27825241
27MP0002734_abnormal_mechanical_nocicepti2.27044596
28MP0003693_abnormal_embryo_hatching2.23844979
29MP0003566_abnormal_cell_adhesion2.23632214
30MP0004957_abnormal_blastocyst_morpholog2.23606437
31MP0001440_abnormal_grooming_behavior2.22931110
32MP0002822_catalepsy2.17177798
33MP0001849_ear_inflammation2.05468557
34MP0004185_abnormal_adipocyte_glucose2.01542910
35MP0003077_abnormal_cell_cycle1.98393021
36MP0003329_amyloid_beta_deposits1.95674849
37MP0008932_abnormal_embryonic_tissue1.92857164
38MP0010352_gastrointestinal_tract_polyps1.92092926
39MP0001905_abnormal_dopamine_level1.90855854
40MP0002733_abnormal_thermal_nociception1.90421949
41MP0000003_abnormal_adipose_tissue1.89759061
42MP0002067_abnormal_sensory_capabilities1.89550735
43MP0009780_abnormal_chondrocyte_physiolo1.88118469
44MP0000537_abnormal_urethra_morphology1.80882962
45MP0001970_abnormal_pain_threshold1.80187478
46MP0002557_abnormal_social/conspecific_i1.76423729
47MP0002184_abnormal_innervation1.75703584
48MP0001730_embryonic_growth_arrest1.75322619
49MP0003786_premature_aging1.75218985
50MP0005623_abnormal_meninges_morphology1.73346154
51MP0000678_abnormal_parathyroid_gland1.72639588
52MP0002060_abnormal_skin_morphology1.72519332
53MP0003787_abnormal_imprinting1.68173303
54MP0000733_abnormal_muscle_development1.67965712
55MP0000778_abnormal_nervous_system1.67025302
56MP0004947_skin_inflammation1.66335005
57MP0002909_abnormal_adrenal_gland1.65937947
58MP0001529_abnormal_vocalization1.65449536
59MP0004858_abnormal_nervous_system1.61354869
60MP0004811_abnormal_neuron_physiology1.61036074
61MP0003879_abnormal_hair_cell1.59943005
62MP0005386_behavior/neurological_phenoty1.59637968
63MP0004924_abnormal_behavior1.59637968
64MP0005646_abnormal_pituitary_gland1.57884440
65MP0000350_abnormal_cell_proliferation1.57186436
66MP0003122_maternal_imprinting1.55608022
67MP0005501_abnormal_skin_physiology1.55527423
68MP0002396_abnormal_hematopoietic_system1.54202817
69MP0008007_abnormal_cellular_replicative1.54171717
70MP0001188_hyperpigmentation1.53503717
71MP0008569_lethality_at_weaning1.53209405
72MP0005645_abnormal_hypothalamus_physiol1.52419294
73MP0004808_abnormal_hematopoietic_stem1.44802558
74MP0003453_abnormal_keratinocyte_physiol1.43835862
75MP0002066_abnormal_motor_capabilities/c1.39767549
76MP0000955_abnormal_spinal_cord1.39423899
77MP0002089_abnormal_postnatal_growth/wei1.38491335
78MP0000858_altered_metastatic_potential1.36815793
79MP0001984_abnormal_olfaction1.36800802
80MP0002080_prenatal_lethality1.35042665
81MP0002882_abnormal_neuron_morphology1.34758626
82MP0000579_abnormal_nail_morphology1.31793844
83MP0004885_abnormal_endolymph1.30266427
84MP0002837_dystrophic_cardiac_calcinosis1.27516298
85MP0003091_abnormal_cell_migration1.26591225
86MP0005621_abnormal_cell_physiology1.26419267
87MP0010030_abnormal_orbit_morphology1.24610138
88MP0001502_abnormal_circadian_rhythm1.24027853
89MP0005257_abnormal_intraocular_pressure1.23514685
90MP0001216_abnormal_epidermal_layer1.22582870
91MP0004272_abnormal_basement_membrane1.20174525
92MP0005058_abnormal_lysosome_morphology1.19073446
93MP0003633_abnormal_nervous_system1.18528559
94MP0004142_abnormal_muscle_tone1.17586202
95MP0001661_extended_life_span1.15242286
96MP0005083_abnormal_biliary_tract1.14439910
97MP0000747_muscle_weakness1.14122287
98MP0004197_abnormal_fetal_growth/weight/1.13774894
99MP0000358_abnormal_cell_content/1.13719994
100MP0005380_embryogenesis_phenotype1.13547742
101MP0001672_abnormal_embryogenesis/_devel1.13547742
102MP0005375_adipose_tissue_phenotype1.12261372
103MP0002086_abnormal_extraembryonic_tissu1.11171467
104MP0000467_abnormal_esophagus_morphology1.09536388
105MP0001243_abnormal_dermal_layer1.08942976
106MP0001697_abnormal_embryo_size1.07377336
107MP0005535_abnormal_body_temperature1.05985800
108MP0008872_abnormal_physiological_respon1.05464611
109MP0002796_impaired_skin_barrier1.05268792
110MP0005023_abnormal_wound_healing1.04121312
111MP0003631_nervous_system_phenotype1.03764853
112MP0005551_abnormal_eye_electrophysiolog1.03435758
113MP0003984_embryonic_growth_retardation1.03105233
114MP0002152_abnormal_brain_morphology1.03011151
115MP0000751_myopathy1.03000069
116MP0003763_abnormal_thymus_physiology1.02864285
117MP0003950_abnormal_plasma_membrane1.02747557
118MP0005384_cellular_phenotype0.98863973
119MP0000313_abnormal_cell_death0.98596627
120MP0009931_abnormal_skin_appearance0.98016247
121MP0001873_stomach_inflammation0.96950582
122MP0002970_abnormal_white_adipose0.95773979
123MP0002088_abnormal_embryonic_growth/wei0.95630399
124MP0004145_abnormal_muscle_electrophysio0.95364207
125MP0008874_decreased_physiological_sensi0.94999472
126MP0002019_abnormal_tumor_incidence0.94963307
127MP0002069_abnormal_eating/drinking_beha0.94272511
128MP0002229_neurodegeneration0.93934689
129MP0008058_abnormal_DNA_repair0.93826586
130MP0002249_abnormal_larynx_morphology0.93466642
131MP0005409_darkened_coat_color0.92850232
132MP0000759_abnormal_skeletal_muscle0.92602078
133MP0005360_urolithiasis0.92224103
134MP0005666_abnormal_adipose_tissue0.89879628
135MP0001881_abnormal_mammary_gland0.88534957
136MP0000490_abnormal_crypts_of0.88327202
137MP0010386_abnormal_urinary_bladder0.88212504
138MP0002006_tumorigenesis0.87682322
139MP0004510_myositis0.87361607
140MP0010771_integument_phenotype0.87075265
141MP0001177_atelectasis0.86936358
142MP0000604_amyloidosis0.86881976
143MP0001963_abnormal_hearing_physiology0.85472635
144MP0002166_altered_tumor_susceptibility0.83710820
145MP0003075_altered_response_to0.83531271
146MP0000428_abnormal_craniofacial_morphol0.83080423
147MP0000762_abnormal_tongue_morphology0.82883613
148MP0010307_abnormal_tumor_latency0.82814772
149MP0006292_abnormal_olfactory_placode0.82373439
150MP0001664_abnormal_digestion0.82095830
151MP0003385_abnormal_body_wall0.81987099
152MP0004085_abnormal_heartbeat0.81342596
153MP0002085_abnormal_embryonic_tissue0.81289959
154MP0003123_paternal_imprinting0.81134815
155MP0004484_altered_response_of0.78906692
156MP0000703_abnormal_thymus_morphology0.78378072
157MP0002234_abnormal_pharynx_morphology0.78353068
158MP0004742_abnormal_vestibular_system0.77436106
159MP0002876_abnormal_thyroid_physiology0.76779661
160MP0005499_abnormal_olfactory_system0.75498635
161MP0005394_taste/olfaction_phenotype0.75498635
162MP0008057_abnormal_DNA_replication0.75348522
163MP0004215_abnormal_myocardial_fiber0.74696775
164MP0002084_abnormal_developmental_patter0.74246199
165MP0003632_abnormal_nervous_system0.74006431
166MP0002090_abnormal_vision0.73561647
167MP0008260_abnormal_autophagy0.73496557
168MP0000631_abnormal_neuroendocrine_gland0.73250492
169MP0000377_abnormal_hair_follicle0.72214135
170MP0002752_abnormal_somatic_nervous0.71280383
171MP0003634_abnormal_glial_cell0.69941118
172MP0003656_abnormal_erythrocyte_physiolo0.66524630
173MP0002114_abnormal_axial_skeleton0.66418113
174MP0000627_abnormal_mammary_gland0.66216988
175MP0003045_fibrosis0.65924633
176MP0000477_abnormal_intestine_morphology0.64287217
177MP0003690_abnormal_glial_cell0.61864746
178MP0000013_abnormal_adipose_tissue0.59079473
179MP0000920_abnormal_myelination0.58159924
180MP0000026_abnormal_inner_ear0.57919787
181MP0003137_abnormal_impulse_conducting0.54372843
182MP0006072_abnormal_retinal_apoptosis0.53595240
183MP0001943_abnormal_respiration0.53437693
184MP0003283_abnormal_digestive_organ0.52132441
185MP0002638_abnormal_pupillary_reflex0.51453727
186MP0003121_genomic_imprinting0.51413078
187MP0005595_abnormal_vascular_smooth0.50381091
188MP0004233_abnormal_muscle_weight0.50370366
189MP0005167_abnormal_blood-brain_barrier0.49195788
190MP0003172_abnormal_lysosome_physiology0.49183626
191MP0008877_abnormal_DNA_methylation0.48835705
192MP0005187_abnormal_penis_morphology0.48681119

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.20609572
2Myokymia (HP:0002411)6.40244630
3Visual hallucinations (HP:0002367)6.07548109
4Focal seizures (HP:0007359)6.04829341
5Epileptic encephalopathy (HP:0200134)5.05523236
6Atonic seizures (HP:0010819)4.99400205
7Febrile seizures (HP:0002373)4.79520841
8Absence seizures (HP:0002121)4.66522389
9Progressive cerebellar ataxia (HP:0002073)4.52347047
10Hyperacusis (HP:0010780)4.44645508
11Dialeptic seizures (HP:0011146)4.37515718
12Generalized tonic-clonic seizures (HP:0002069)4.25791441
13Premature rupture of membranes (HP:0001788)4.02446869
14Supranuclear gaze palsy (HP:0000605)3.90476977
15Cerebral inclusion bodies (HP:0100314)3.87852924
16Hyperventilation (HP:0002883)3.77124929
17Protrusio acetabuli (HP:0003179)3.73894861
18Broad-based gait (HP:0002136)3.46341827
19Impaired vibration sensation in the lower limbs (HP:0002166)3.46172886
20Distal lower limb amyotrophy (HP:0008944)3.44816943
21Upper limb amyotrophy (HP:0009129)3.44789678
22Distal upper limb amyotrophy (HP:0007149)3.44789678
23Ankyloglossia (HP:0010296)3.38458860
24Depression (HP:0000716)3.32330471
25Neurofibrillary tangles (HP:0002185)3.29665387
26Abnormality of oral frenula (HP:0000190)3.25431765
27Action tremor (HP:0002345)3.19365332
28Amblyopia (HP:0000646)3.19234590
29Limb dystonia (HP:0002451)3.16926022
30Dysmetria (HP:0001310)3.16552644
31Cholecystitis (HP:0001082)3.15980626
32Abnormal gallbladder physiology (HP:0012438)3.15980626
33Anxiety (HP:0000739)3.15720120
34Fragile skin (HP:0001030)3.14348807
35Truncal ataxia (HP:0002078)3.12817206
36Poor eye contact (HP:0000817)3.04221516
37Progressive inability to walk (HP:0002505)3.01946415
38Increased connective tissue (HP:0009025)3.00197368
39Abnormality of binocular vision (HP:0011514)2.98123606
40Diplopia (HP:0000651)2.98123606
41Mutism (HP:0002300)2.97552891
42Excessive salivation (HP:0003781)2.97482979
43Drooling (HP:0002307)2.97482979
44Postural instability (HP:0002172)2.93806741
45Truncus arteriosus (HP:0001660)2.93574517
46Dysdiadochokinesis (HP:0002075)2.93252174
47Gaze-evoked nystagmus (HP:0000640)2.92944780
48Abnormal eating behavior (HP:0100738)2.91607772
49Urinary bladder sphincter dysfunction (HP:0002839)2.89415180
50Abnormal social behavior (HP:0012433)2.80599405
51Impaired social interactions (HP:0000735)2.80599405
52Hemiparesis (HP:0001269)2.79167460
53Lower limb amyotrophy (HP:0007210)2.72948547
54Long palpebral fissure (HP:0000637)2.72591221
55Ankle clonus (HP:0011448)2.72208310
56Cervical subluxation (HP:0003308)2.71941852
57Delusions (HP:0000746)2.71903866
58Elfin facies (HP:0004428)2.68519158
59Achilles tendon contracture (HP:0001771)2.67904906
60Spinal rigidity (HP:0003306)2.67638527
61Bradykinesia (HP:0002067)2.67183856
62Broad face (HP:0000283)2.66879621
63Abnormality of the lower motor neuron (HP:0002366)2.64360061
64Bladder diverticulum (HP:0000015)2.59207925
65Disproportionate tall stature (HP:0001519)2.56876980
66Papilledema (HP:0001085)2.56639027
67Epileptiform EEG discharges (HP:0011182)2.55669579
68Absent speech (HP:0001344)2.54857098
69Thin bony cortex (HP:0002753)2.53981982
70Premature skin wrinkling (HP:0100678)2.52561310
71Genetic anticipation (HP:0003743)2.51433979
72Entropion (HP:0000621)2.51170935
73Renal duplication (HP:0000075)2.50993635
74Flat cornea (HP:0007720)2.49361528
75Impaired smooth pursuit (HP:0007772)2.49092258
76Reticulocytosis (HP:0001923)2.47884640
77Selective tooth agenesis (HP:0001592)2.46505566
78Ulnar bowing (HP:0003031)2.45820932
79Ankle contracture (HP:0006466)2.45403068
80Hypertensive crisis (HP:0100735)2.42659767
81Squamous cell carcinoma (HP:0002860)2.41334512
82EEG with generalized epileptiform discharges (HP:0011198)2.38275969
83Spastic gait (HP:0002064)2.36974461
84Patellar dislocation (HP:0002999)2.36735453
85Pheochromocytoma (HP:0002666)2.35378632
86Vertebral compression fractures (HP:0002953)2.35266389
87Urinary urgency (HP:0000012)2.34679701
88Mildly elevated creatine phosphokinase (HP:0008180)2.33928648
89Biconcave vertebral bodies (HP:0004586)2.32817601
90Hand muscle atrophy (HP:0009130)2.32718473
91Generalized myoclonic seizures (HP:0002123)2.32340951
92Status epilepticus (HP:0002133)2.31910862
93Inability to walk (HP:0002540)2.31445351
94Impaired vibratory sensation (HP:0002495)2.30689002
95Poikiloderma (HP:0001029)2.30192347
96Polyphagia (HP:0002591)2.27620390
97Atrophic scars (HP:0001075)2.26264202
98Brittle hair (HP:0002299)2.26081411
99Abnormality of ocular smooth pursuit (HP:0000617)2.23920159
100Cerebral aneurysm (HP:0004944)2.23847107
101Stereotypic behavior (HP:0000733)2.23587852
102Abnormality of the Achilles tendon (HP:0005109)2.23297085
103Hemiplegia (HP:0002301)2.22662233
104Lower limb muscle weakness (HP:0007340)2.20641934
105Overriding aorta (HP:0002623)2.20553818
106Fetal akinesia sequence (HP:0001989)2.19895184
107Hyperthyroidism (HP:0000836)2.19182478
108Sparse lateral eyebrow (HP:0005338)2.18907725
109Elbow flexion contracture (HP:0002987)2.18201451
110Hypsarrhythmia (HP:0002521)2.17734305
111Abnormality of the tricuspid valve (HP:0001702)2.17399865
112Ventricular fibrillation (HP:0001663)2.16987695
113Focal dystonia (HP:0004373)2.15927618
114Nail dystrophy (HP:0008404)2.15158539
115Abnormality of the corticospinal tract (HP:0002492)2.14709500
116Generalized amyotrophy (HP:0003700)2.14355495
117Rapidly progressive (HP:0003678)2.13974528
118Torticollis (HP:0000473)2.13608567
119Progressive muscle weakness (HP:0003323)2.13028628
120Shallow orbits (HP:0000586)2.11267118
121Psychosis (HP:0000709)2.11012769
122Atelectasis (HP:0100750)2.10421623
123Termporal pattern (HP:0011008)2.09860993
124Insidious onset (HP:0003587)2.09860993
125Neuroendocrine neoplasm (HP:0100634)2.08111955
126Trismus (HP:0000211)2.07882314
127Unilateral renal agenesis (HP:0000122)2.07812497
128Protruding tongue (HP:0010808)2.04895656
129Intention tremor (HP:0002080)2.04552747
130Increased nuchal translucency (HP:0010880)2.04418706
131Abnormality of salivation (HP:0100755)2.03191663
132Short nail (HP:0001799)2.02578136
133Gait ataxia (HP:0002066)2.02231219
134Pointed chin (HP:0000307)2.01494096
135Stridor (HP:0010307)2.01182383
136Rigidity (HP:0002063)2.01162745
137Microvesicular hepatic steatosis (HP:0001414)2.01004652
138J-shaped sella turcica (HP:0002680)1.99863086
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98027574
140Abnormality of reticulocytes (HP:0004312)1.97957037
141Difficulty climbing stairs (HP:0003551)1.96992973
142Hypoventilation (HP:0002791)1.96875810
143Scanning speech (HP:0002168)1.94653271
144Insomnia (HP:0100785)1.94069359
145Natal tooth (HP:0000695)1.93687826
146Obstructive sleep apnea (HP:0002870)1.93417805
147Abnormality of the distal phalanges of the toes (HP:0010182)1.92924007
148Incomplete penetrance (HP:0003829)1.92856983
149Neuronal loss in central nervous system (HP:0002529)1.92828982
150Wormian bones (HP:0002645)1.92545310
151Progressive external ophthalmoplegia (HP:0000590)1.92310001
152Blue irides (HP:0000635)1.90788684
153Dysmetric saccades (HP:0000641)1.89100747
154Pili torti (HP:0003777)1.88909167
155Agitation (HP:0000713)1.88723423
156Megalencephaly (HP:0001355)1.86833775
157Spinal cord lesions (HP:0100561)1.85171967
158Syringomyelia (HP:0003396)1.85171967
159Diaphragmatic weakness (HP:0009113)1.84054026
160Absent/shortened dynein arms (HP:0200106)1.83379063
161Dynein arm defect of respiratory motile cilia (HP:0012255)1.83379063
162Thickened helices (HP:0000391)1.83045768
163Unsteady gait (HP:0002317)1.82788456
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.80829451
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80565176
166Persistence of primary teeth (HP:0006335)1.80216491
167Failure to thrive in infancy (HP:0001531)1.79894296
168Relative macrocephaly (HP:0004482)1.78915402
169Gastroesophageal reflux (HP:0002020)1.78811628
170Reduced subcutaneous adipose tissue (HP:0003758)1.78597563
171Urethral obstruction (HP:0000796)1.78408657
172Anosmia (HP:0000458)1.78040458
173Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77111762
174Chromsome breakage (HP:0040012)1.76820506
175Deviation of the thumb (HP:0009603)1.76542860
176Craniofacial dystonia (HP:0012179)1.76193194
177Retinal dysplasia (HP:0007973)1.75685933
178Bowel diverticulosis (HP:0005222)1.74685057
179Clumsiness (HP:0002312)1.73292024
180Fatigue (HP:0012378)1.73176866
181Mitral regurgitation (HP:0001653)1.72717024
182Ragged-red muscle fibers (HP:0003200)1.72668748
183Dyskinesia (HP:0100660)1.72610490
184Decreased subcutaneous fat (HP:0001002)1.72360388
185Abnormality of subcutaneous fat tissue (HP:0001001)1.70082135
186Blue sclerae (HP:0000592)1.68778727
187Abnormal EKG (HP:0003115)1.68160596
188Syncope (HP:0001279)1.67686936
189Amyotrophic lateral sclerosis (HP:0007354)1.67571206
190Proximal placement of thumb (HP:0009623)1.66558285
191Seborrheic dermatitis (HP:0001051)1.65691587
192Advanced eruption of teeth (HP:0006288)1.65122375
193Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64619967
194Absent epiphyses (HP:0010577)1.64619967
195Rough bone trabeculation (HP:0100670)1.64612147
196Renovascular hypertension (HP:0100817)1.62849700
197Myopathic facies (HP:0002058)1.61625352
198Bowel incontinence (HP:0002607)1.61264124
199Spinal cord compression (HP:0002176)1.60585115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.13292175
2MST1R4.94574644
3EPHA44.22188197
4TRIB33.98803199
5MAP3K93.64421507
6EPHA23.53000324
7SMG13.29597748
8SIK13.23668535
9EEF2K3.09657532
10MAP3K43.06003530
11ICK2.92469629
12IRAK32.85986024
13MINK12.75050861
14MAP3K122.70695649
15RIPK42.62374941
16MET2.60748146
17NME22.56094715
18MAP2K72.44554070
19CDK122.24739226
20PNCK2.18227337
21MARK12.10911649
22KSR22.08643402
23MAP2K42.04642320
24PLK22.03895910
25GRK51.99427242
26PAK61.91184322
27CASK1.86116850
28ARAF1.85576805
29NTRK21.81194562
30MAP3K131.73307335
31SIK21.73214899
32PRKD31.70631422
33BUB11.69949425
34KSR11.69097118
35FES1.67583768
36NTRK11.66890461
37DAPK21.61980563
38PKN21.54054552
39NME11.54027421
40CDK51.53068385
41PTK21.52371953
42PTK2B1.49676388
43STK381.40483505
44TNIK1.38641328
45PRKCG1.36931307
46PDGFRA1.36921699
47CAMKK11.36784871
48DAPK11.36151148
49TTK1.36038320
50FGFR41.35292435
51CAMK2A1.33956680
52PRPF4B1.31409376
53ERN11.30736596
54SCYL21.29752105
55PAK41.29720651
56NEK21.29113393
57PIM21.26220602
58RAF11.26204270
59TTN1.25131281
60MAP3K141.24293475
61FGR1.21623390
62EIF2AK11.16523896
63CAMK2B1.11186517
64MTOR1.10958561
65BMPR21.09159280
66MAP3K81.08548196
67MAPK131.07432268
68PRKCI1.06178512
69CAMK11.00854790
70MAP3K100.95952232
71PTK60.94646144
72CDK70.94483438
73CLK10.93046107
74TNK20.92926540
75DYRK1A0.91340120
76PAK20.90939987
77MAP3K20.90096080
78UHMK10.89737101
79CDK40.88946152
80CHEK20.88205059
81TESK10.87769442
82CDC70.87048243
83CDK80.86583387
84TESK20.85701621
85LATS20.85203488
86ERBB40.84546088
87MAPK110.84057410
88GRK60.83376053
89CDK180.81350624
90PAK30.80816715
91SIK30.80519202
92FER0.80476689
93CDK190.80387835
94CDK150.80235291
95CDK140.79471929
96CAMK1G0.79141726
97NEK10.78251998
98CAMK2D0.75556164
99TYRO30.75326110
100RPS6KB20.75266562
101TSSK60.74527111
102TAOK20.73949381
103MAPKAPK50.72540097
104CSNK1G20.70828969
105TRPM70.70707230
106CDK11A0.70688546
107BRD40.70658879
108PRKCH0.70211433
109SGK10.69402393
110MAP3K70.68004516
111STK110.66775740
112EPHB10.66660519
113TBK10.64328841
114BRSK10.64145842
115RET0.63824549
116MAP2K30.62394888
117WEE10.62195498
118CHEK10.61704297
119PHKG10.61174550
120PHKG20.61174550
121PDK10.60784355
122BMX0.60372509
123MAP2K60.59764771
124DMPK0.58192490
125MAP3K10.56289065
126PRKCE0.55753894
127CAMK2G0.54459416
128ALK0.54334150
129CAMKK20.53783221
130PDPK10.53386122
131OXSR10.53190625
132ROCK20.52560953
133STK100.50042670
134SGK2230.49697059
135SGK4940.49697059
136EIF2AK20.48967268
137MAPK100.48556678
138GRK70.48511537
139ILK0.47885608
140PRKCZ0.46653568
141FYN0.46162304
142RPS6KA30.44889208
143MOS0.44854588
144LMTK20.44463619
145ATR0.44425009
146PINK10.44219675
147BRAF0.43184536
148MAPKAPK20.43157592
149IRAK20.43068962
150FLT30.42670536
151AURKB0.42532223
152CDK90.41648843
153CDC42BPA0.40441018
154NEK60.40195872
155CDK10.39467243
156MARK20.39364880
157DDR20.39239170
158MAP3K60.37376107
159AURKA0.37033700
160SRPK10.36185078
161CDK20.35738491
162PRKCA0.35445332
163MAP2K10.33968106
164PRKCB0.33950896
165MAPKAPK30.33769783
166SGK20.33281557
167PRKG20.32851909
168PRKACA0.32431761
169LIMK10.32040764
170CSNK1G30.31264398
171PBK0.31237943
172CSNK1E0.29091530
173PRKCQ0.28185955
174PRKD20.27431978

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.62437431
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35535466
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12914465
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.05478196
5DNA replication_Homo sapiens_hsa030302.94902001
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89639400
7Long-term potentiation_Homo sapiens_hsa047202.87957493
8Amphetamine addiction_Homo sapiens_hsa050312.82927767
9GABAergic synapse_Homo sapiens_hsa047272.82041622
10Circadian entrainment_Homo sapiens_hsa047132.74564195
11Glutamatergic synapse_Homo sapiens_hsa047242.71662428
12Olfactory transduction_Homo sapiens_hsa047402.49747687
13Morphine addiction_Homo sapiens_hsa050322.49456683
14Salivary secretion_Homo sapiens_hsa049702.30175932
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25803113
16Dopaminergic synapse_Homo sapiens_hsa047282.24235409
17Biosynthesis of amino acids_Homo sapiens_hsa012302.13493266
18Chronic myeloid leukemia_Homo sapiens_hsa052202.11168518
19Bladder cancer_Homo sapiens_hsa052192.03073611
20Insulin secretion_Homo sapiens_hsa049111.94790251
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.93916448
22One carbon pool by folate_Homo sapiens_hsa006701.92872737
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.90018476
24Fructose and mannose metabolism_Homo sapiens_hsa000511.89944370
25Taste transduction_Homo sapiens_hsa047421.88740816
26Gastric acid secretion_Homo sapiens_hsa049711.88117817
27Cocaine addiction_Homo sapiens_hsa050301.87725297
28Serotonergic synapse_Homo sapiens_hsa047261.86911267
29Collecting duct acid secretion_Homo sapiens_hsa049661.83723696
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83622981
31Calcium signaling pathway_Homo sapiens_hsa040201.80206878
32Cholinergic synapse_Homo sapiens_hsa047251.79953251
33Long-term depression_Homo sapiens_hsa047301.78828256
34Renin secretion_Homo sapiens_hsa049241.71364189
35Cell cycle_Homo sapiens_hsa041101.70228735
36Base excision repair_Homo sapiens_hsa034101.67193828
37Oxytocin signaling pathway_Homo sapiens_hsa049211.65202832
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64291004
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56628564
40Pentose phosphate pathway_Homo sapiens_hsa000301.55294527
41Nucleotide excision repair_Homo sapiens_hsa034201.55242395
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54229247
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52848535
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52093530
45Other glycan degradation_Homo sapiens_hsa005111.50676151
46Thyroid cancer_Homo sapiens_hsa052161.49980332
47Small cell lung cancer_Homo sapiens_hsa052221.46857755
48GnRH signaling pathway_Homo sapiens_hsa049121.46159995
49Spliceosome_Homo sapiens_hsa030401.44305957
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39057327
51mRNA surveillance pathway_Homo sapiens_hsa030151.34863003
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34502111
53Acute myeloid leukemia_Homo sapiens_hsa052211.33223008
54Mismatch repair_Homo sapiens_hsa034301.32824885
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32432371
56RNA transport_Homo sapiens_hsa030131.32208417
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32029785
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31400464
59Vitamin B6 metabolism_Homo sapiens_hsa007501.27352506
60cAMP signaling pathway_Homo sapiens_hsa040241.27065020
61Pyrimidine metabolism_Homo sapiens_hsa002401.25937715
62Pancreatic cancer_Homo sapiens_hsa052121.24932966
63Gap junction_Homo sapiens_hsa045401.22676772
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22574352
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19741857
66MicroRNAs in cancer_Homo sapiens_hsa052061.17568134
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16707644
68Cardiac muscle contraction_Homo sapiens_hsa042601.15163272
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14351389
70Focal adhesion_Homo sapiens_hsa045101.08582801
71Type II diabetes mellitus_Homo sapiens_hsa049301.07793532
72Vibrio cholerae infection_Homo sapiens_hsa051101.07246210
73Estrogen signaling pathway_Homo sapiens_hsa049151.06923069
74Galactose metabolism_Homo sapiens_hsa000521.06691106
75N-Glycan biosynthesis_Homo sapiens_hsa005101.05600980
76Shigellosis_Homo sapiens_hsa051311.04089908
77Glioma_Homo sapiens_hsa052141.02583698
78Sulfur relay system_Homo sapiens_hsa041221.02220774
79Melanogenesis_Homo sapiens_hsa049161.01770566
80Carbon metabolism_Homo sapiens_hsa012001.01448225
81Axon guidance_Homo sapiens_hsa043601.01424423
82cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01264846
83ECM-receptor interaction_Homo sapiens_hsa045121.01138516
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00947931
85Viral carcinogenesis_Homo sapiens_hsa052030.97073830
86Proteoglycans in cancer_Homo sapiens_hsa052050.95348302
87Notch signaling pathway_Homo sapiens_hsa043300.94712225
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.93267769
89Lysine degradation_Homo sapiens_hsa003100.92691935
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91606258
91Phototransduction_Homo sapiens_hsa047440.89412016
92Homologous recombination_Homo sapiens_hsa034400.86679734
93ErbB signaling pathway_Homo sapiens_hsa040120.86009244
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.85984544
95Apoptosis_Homo sapiens_hsa042100.84962541
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83364777
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82922467
98p53 signaling pathway_Homo sapiens_hsa041150.82506806
99Pancreatic secretion_Homo sapiens_hsa049720.81988135
100Non-homologous end-joining_Homo sapiens_hsa034500.81759779
101Insulin signaling pathway_Homo sapiens_hsa049100.81641869
102Oocyte meiosis_Homo sapiens_hsa041140.81493517
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80452114
104Alzheimers disease_Homo sapiens_hsa050100.80197061
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79646096
106Choline metabolism in cancer_Homo sapiens_hsa052310.78869675
107Phenylalanine metabolism_Homo sapiens_hsa003600.77586297
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.77426044
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.75729255
110HTLV-I infection_Homo sapiens_hsa051660.71570148
111Thyroid hormone synthesis_Homo sapiens_hsa049180.71128051
112Dorso-ventral axis formation_Homo sapiens_hsa043200.71045727
113Oxidative phosphorylation_Homo sapiens_hsa001900.69614206
114Endometrial cancer_Homo sapiens_hsa052130.69394125
115Dilated cardiomyopathy_Homo sapiens_hsa054140.65937543
116Hepatitis B_Homo sapiens_hsa051610.65435962
117Type I diabetes mellitus_Homo sapiens_hsa049400.64649239
118African trypanosomiasis_Homo sapiens_hsa051430.63262346
119MAPK signaling pathway_Homo sapiens_hsa040100.62969538
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62177708
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61204710
122Prostate cancer_Homo sapiens_hsa052150.59496232
123VEGF signaling pathway_Homo sapiens_hsa043700.59478115
124Glucagon signaling pathway_Homo sapiens_hsa049220.58978991
125Arginine biosynthesis_Homo sapiens_hsa002200.56712565
126Fanconi anemia pathway_Homo sapiens_hsa034600.56626871
127Renal cell carcinoma_Homo sapiens_hsa052110.53686094
128Epstein-Barr virus infection_Homo sapiens_hsa051690.53260733
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51236278
130Inositol phosphate metabolism_Homo sapiens_hsa005620.51226918
131Ras signaling pathway_Homo sapiens_hsa040140.50579417
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50571255
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50245742
134Rap1 signaling pathway_Homo sapiens_hsa040150.48568610
135Purine metabolism_Homo sapiens_hsa002300.48180668
136Hippo signaling pathway_Homo sapiens_hsa043900.48076223
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47943006
138Fatty acid biosynthesis_Homo sapiens_hsa000610.47908832
139B cell receptor signaling pathway_Homo sapiens_hsa046620.47826611
140Alcoholism_Homo sapiens_hsa050340.47557026
141AMPK signaling pathway_Homo sapiens_hsa041520.47024458
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46782249
143Parkinsons disease_Homo sapiens_hsa050120.46348767
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.44151824
145Hepatitis C_Homo sapiens_hsa051600.43797228
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42627403
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42617066
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42484649
149Prolactin signaling pathway_Homo sapiens_hsa049170.42319834
150Prion diseases_Homo sapiens_hsa050200.41418231
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40906120
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.40792302
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.39909258
154Bile secretion_Homo sapiens_hsa049760.38734878
155Nitrogen metabolism_Homo sapiens_hsa009100.38444012
156Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37248190
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36596446
158Endocytosis_Homo sapiens_hsa041440.36104673
159Rheumatoid arthritis_Homo sapiens_hsa053230.34455377
160Wnt signaling pathway_Homo sapiens_hsa043100.32279585
161Huntingtons disease_Homo sapiens_hsa050160.30949683
162Circadian rhythm_Homo sapiens_hsa047100.29999853
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29780557
164Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29059471
165Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29045390
166mTOR signaling pathway_Homo sapiens_hsa041500.29019994
167Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28766258
168Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25728038
169Glycerophospholipid metabolism_Homo sapiens_hsa005640.24315347
170Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23678188
171Mineral absorption_Homo sapiens_hsa049780.23325981
172Ovarian steroidogenesis_Homo sapiens_hsa049130.22554498
173Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22381730
174Chemokine signaling pathway_Homo sapiens_hsa040620.19374901
175Non-small cell lung cancer_Homo sapiens_hsa052230.19210149

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »